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Wyszukujesz frazę ""Inflammasomes"" wg kryterium: Temat


Tytuł :
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Autorzy :
Gong Q; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Robinson K; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore.
Xu C; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Huynh PT; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technology University, 11 Mandalay Road, 308232, Singapore, Singapore.
Chong KHC; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Tan EYJ; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Zhang J; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Boo ZZ; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Teo DET; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore.
Lay K; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore.
Zhang Y; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Lim JSY; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore.
Goh WI; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore.
Wright G; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore.
Zhong FL; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore. .; Lee Kong Chian School of Medicine, Nanyang Technology University, 11 Mandalay Road, 308232, Singapore, Singapore. .; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore. .
Reversade B; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore. .; Genome Institute of Singapore, Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore. .; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore, Singapore. .; The Medical Genetics Department, School of Medicine (KUSoM), Koç University, 34010, Istanbul, Turkey. .
Wu B; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore. .; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 188. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Apoptosis Regulatory Proteins/*metabolism
CARD Signaling Adaptor Proteins/*metabolism
Inflammasomes/*chemistry
Inflammasomes/*metabolism
Neoplasm Proteins/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/genetics ; CARD Signaling Adaptor Proteins/genetics ; Caspase 1/metabolism ; Cryoelectron Microscopy ; HEK293 Cells ; Humans ; Inflammasomes/genetics ; Inflammation ; Molecular Docking Simulation ; Mutation ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Autorzy :
Robert Hollingsworth L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA.
David L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Li Y; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Griswold AR; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Ruan J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.
Sharif H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Fontana P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Orth-He EL; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Fu TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Biological Chemistry and Pharmacology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Bachovchin DA; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. .; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA. .; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 189. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Ankyrins/*metabolism
Apoptosis Regulatory Proteins/*metabolism
CARD Signaling Adaptor Proteins/*metabolism
Inflammasomes/*metabolism
Neoplasm Proteins/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Ankyrins/chemistry ; Apoptosis ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/genetics ; CARD Signaling Adaptor Proteins/chemistry ; CARD Signaling Adaptor Proteins/genetics ; Caspase 1/metabolism ; Caspase Activation and Recruitment Domain ; Cryoelectron Microscopy ; Death Domain Receptor Signaling Adaptor Proteins/chemistry ; Death Domain Receptor Signaling Adaptor Proteins/metabolism ; HEK293 Cells ; Humans ; Inflammasomes/chemistry ; Inflammasomes/ultrastructure ; Models, Molecular ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Protein Interaction Domains and Motifs ; Signal Transduction
Czasopismo naukowe
Tytuł :
Detection of Viral Infections by Innate Immunity.
Autorzy :
Carty M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: .
Guy C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Bowie AG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114316. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunity, Innate/*immunology
Inflammasomes/*immunology
SARS-CoV-2/*immunology
Virus Diseases/*immunology
Animals ; Humans ; Inflammasomes/metabolism ; Receptors, Pattern Recognition/immunology ; Receptors, Pattern Recognition/metabolism ; SARS-CoV-2/metabolism ; Virus Diseases/diagnosis ; Virus Diseases/metabolism
Czasopismo naukowe
Tytuł :
Fast diagnostic test for familial Mediterranean fever based on a kinase inhibitor.
Autorzy :
Magnotti F; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France.
Malsot T; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France.
Georgin-Lavialle S; Internal Medicine, Tenon Hospital, AP-HP, Paris, France.; CEREMAIA (Centre de Référence des Maladies Autoinflammatoires et des Amyloses), Paris, France.
Abbas F; Biostatistics, Pôle de Santé Publique,CNRS UMR5308, Hospices Civils de Lyon, Lyon, France.
Martin A; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France.
Belot A; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France.; CEREMAIA (Centre de Référence des Maladies Autoinflammatoires et des Amyloses), Paris, France.; Department of Paediatric Nephrology, Rheumatology, Dermatology, Hôpital Femme-Mère Enfant, Université Claude Bernard-Lyon 1, Hospices Civils de Lyon, Bron, France.
Fauter M; Internal Medicine, University Hospital Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Internal Medicine, Hospices Civils de Lyon, Lyon, France.
Rabilloud M; Biostatistics, Pôle de Santé Publique,CNRS UMR5308, Hospices Civils de Lyon, Lyon, France.
Gerfaud-Valentin M; Internal Medicine, University Hospital Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
Sève P; Internal Medicine, University Hospital Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
Duquesne A; Department of Paediatric Nephrology, Rheumatology, Dermatology, Hôpital Femme-Mère Enfant, Université Claude Bernard-Lyon 1, Hospices Civils de Lyon, Bron, France.
Hot A; Internal Medicine, University Hospital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Durupt S; Internal Medicine, University Hospital Lyon Sud, Hospices Civils de Lyon, Lyon, France.
Savey L; Internal Medicine, Tenon Hospital, AP-HP, Paris, France.
Giurgea I; Genetics, Armand-Trousseau Hospital, APHP, Sorbonne University, Paris, Île-de-France, France.
Grateau G; Internal Medicine, Tenon Hospital, AP-HP, Paris, France.; CEREMAIA (Centre de Référence des Maladies Autoinflammatoires et des Amyloses), Paris, France.
Henry T; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France.
Jamilloux Y; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France .; Internal Medicine, University Hospital Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
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Źródło :
Annals of the rheumatic diseases [Ann Rheum Dis] 2021 Jan; Vol. 80 (1), pp. 128-132. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Familial Mediterranean Fever/*diagnosis
Inflammasomes/*drug effects
Interleukin-1beta/*drug effects
Monocytes/*drug effects
Protein Kinase Inhibitors/*pharmacology
Pyrin/*drug effects
Pyroptosis/*drug effects
Staurosporine/*analogs & derivatives
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Juvenile/diagnosis ; Behcet Syndrome/diagnosis ; Case-Control Studies ; Child ; Child, Preschool ; Cryopyrin-Associated Periodic Syndromes/diagnosis ; Familial Mediterranean Fever/genetics ; Familial Mediterranean Fever/immunology ; Female ; Fever/diagnosis ; Fever of Unknown Origin/diagnosis ; Hereditary Autoinflammatory Diseases/diagnosis ; Humans ; Immunologic Tests/methods ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Interleukin-1beta/immunology ; Interleukin-1beta/metabolism ; Lupus Erythematosus, Systemic/diagnosis ; Male ; Mevalonate Kinase Deficiency/diagnosis ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Pyrin/genetics ; Pyrin/immunology ; Pyrin/metabolism ; Sensitivity and Specificity ; Sepsis/diagnosis ; Staurosporine/pharmacology ; Still's Disease, Adult-Onset/diagnosis ; Young Adult
SCR Disease Name :
Periodic fever, familial, autosomal dominant
Czasopismo naukowe
Tytuł :
NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury.
Autorzy :
Zheng D; School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
Shi Z; School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
Yang M; School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
Liang B; School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
Zhou X; School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
Jing L; School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address: .
Sun Z; School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
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Źródło :
Chemosphere [Chemosphere] 2021 Mar; Vol. 267, pp. 128867. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammasomes*
Pyroptosis*
Animals ; Bromobenzenes ; Endothelial Cells ; Endothelium ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Proteins ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
NLRP1: a jack of all trades, or a master of one?
Autorzy :
Bachovchin DA; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 423-425.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Inflammasomes*/metabolism
Peptide Hydrolases*
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis Regulatory Proteins/metabolism ; Cysteine Endopeptidases ; Humans ; Viral Proteins
Czasopismo naukowe
Tytuł :
Inflammasome activation in acute lung injury.
Autorzy :
McVey MJ; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Physics, Ryerson University, Toronto, Ontario, Canada.
Steinberg BE; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Goldenberg NM; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Feb 01; Vol. 320 (2), pp. L165-L178. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Lung Injury/*immunology
Inflammasomes/*immunology
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Pneumonia/*immunology
Acute Lung Injury/metabolism ; Acute Lung Injury/pathology ; Animals ; Humans ; Inflammasomes/metabolism ; Pneumonia/metabolism ; Pneumonia/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Human NLRP1 is a sensor for double-stranded RNA.
Autorzy :
Bauernfried S; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Scherr MJ; Max-Planck Institute of Biochemistry, Martinsried, Germany.
Pichlmair A; Institute of Virology, Technical University of Munich, School of Medicine, Munich, Germany.; German Center for Infection Research (DZIF), Munich, Germany.
Duderstadt KE; Max-Planck Institute of Biochemistry, Martinsried, Germany.; Physics Department, Technical University of Munich, Garching, Germany.
Hornung V; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany. .; Max-Planck Institute of Biochemistry, Martinsried, Germany.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 29; Vol. 371 (6528). Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Adaptor Proteins, Signal Transducing/*metabolism
Apoptosis Regulatory Proteins/*metabolism
Host-Pathogen Interactions/*immunology
Inflammasomes/*immunology
RNA, Double-Stranded/*metabolism
RNA, Viral/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Alphavirus Infections/immunology ; Animals ; Apoptosis Regulatory Proteins/chemistry ; HEK293 Cells ; Humans ; Hydrolysis ; Inflammasomes/metabolism ; Keratinocytes/immunology ; Keratinocytes/metabolism ; Keratinocytes/virology ; Mice ; Mice, Transgenic ; Protein Domains ; Semliki forest virus/immunology ; Semliki forest virus/physiology ; Virus Replication
Czasopismo naukowe
Tytuł :
Key Components of Inflammasome and Pyroptosis Pathways Are Deficient in Canines and Felines, Possibly Affecting Their Response to SARS-CoV-2 Infection.
Autorzy :
Cui H; Institute of Basic Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.; Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Zhang L; Institute of Basic Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.; Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jan 28; Vol. 11, pp. 592622. Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cat Diseases*/immunology
Cat Diseases*/virology
Dog Diseases*/immunology
Dog Diseases*/virology
COVID-19/*immunology
COVID-19/*veterinary
Inflammasomes/*immunology
Pyroptosis/*immunology
Animals ; Cats ; Cytokine Release Syndrome/genetics ; Cytokine Release Syndrome/immunology ; Dogs ; Genomics ; Humans ; Inflammasomes/genetics ; Pyroptosis/genetics ; SARS-CoV-2 ; Tigers
Czasopismo naukowe
Tytuł :
High glucose induces pyroptosis of retinal microglia through NLPR3 inflammasome signaling.
Autorzy :
Huang L; The First Affiliated Hospital of Fujian Medical University, China.
You J; The First Affiliated Hospital of Fujian Medical University, China.
Yao Y; The First Affiliated Hospital of Fujian Medical University, China.
Xie M; The First Affiliated Hospital of Fujian Medical University, China.
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Źródło :
Arquivos brasileiros de oftalmologia [Arq Bras Oftalmol] 2021 Jan-Feb; Vol. 84 (1), pp. 67-73.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammasomes*
Pyroptosis*
Glucose ; Humans ; Interleukin-1beta ; Microglia ; NLR Family, Pyrin Domain-Containing 3 Protein
Czasopismo naukowe
Tytuł :
Inflammasome formation in the lungs of patients with fatal COVID-19.
Autorzy :
Toldo S; VCU Pauley Heart Center, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA, 23298, USA. .
Bussani R; Istituto di Anatomia Patologica, Università di Trieste, Trieste, Italy.
Nuzzi V; Istitituto di Cardiologia, Università di Trieste, Trieste, Italy.
Bonaventura A; VCU Pauley Heart Center, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA, 23298, USA.
Mauro AG; VCU Pauley Heart Center, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA, 23298, USA.
Cannatà A; Istitituto di Cardiologia, Università di Trieste, Trieste, Italy.
Pillappa R; Anatomic Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Sinagra G; Anatomic Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Nana-Sinkam P; Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Sime P; Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Abbate A; VCU Pauley Heart Center, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA, 23298, USA.
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Źródło :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2021 Jan; Vol. 70 (1), pp. 7-10. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammasomes*
COVID-19/*pathology
Lung/*pathology
Adult ; Aged ; Autopsy ; CARD Signaling Adaptor Proteins/analysis ; CARD Signaling Adaptor Proteins/metabolism ; Caspase 1/analysis ; Caspase 1/metabolism ; Cytokine Release Syndrome/metabolism ; Cytokine Release Syndrome/pathology ; Female ; Heart Arrest/etiology ; Humans ; Leukocytes/pathology ; Male ; Middle Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/analysis ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pneumonia, Viral/etiology ; Pneumonia, Viral/pathology ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/pathology
Czasopismo naukowe
Tytuł :
Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases.
Autorzy :
Wu AG; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Zhou XG; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Qiao G; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Yu L; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Tang Y; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China. Electronic address: .
Yan L; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Qiu WQ; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Pan R; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Yu CL; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Law BY; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China. Electronic address: .
Qin DL; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
Wu JM; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology; College of Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Jan; Vol. 65, pp. 101202. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Inflammasomes*
Neurodegenerative Diseases*
Autophagy ; Female ; Humans ; Male ; Microglia ; NLR Family, Pyrin Domain-Containing 3 Protein
Czasopismo naukowe
Tytuł :
Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice.
Autorzy :
Zhao J; Department of Surgery, Third People's Hospital of Liaocheng City, Liaocheng, Shandong, China.
Wang Z; Department of Surgery, Third People's Hospital of Liaocheng City, Liaocheng, Shandong, China.
Yuan Z; Department of Surgery, Third People's Hospital of Liaocheng City, Liaocheng, Shandong, China.
Lv S; Department of Orthopedic, Third People's Hospital of Liaocheng City, Liaocheng, Shandong, China.
Su Q; Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
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Źródło :
Diabetes & vascular disease research [Diab Vasc Dis Res] 2020 Nov-Dec; Vol. 17 (6), pp. 1479164120977441.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Aorta/*drug effects
Aortic Diseases/*prevention & control
Atherosclerosis/*prevention & control
Flavonoids/*pharmacology
Inflammasomes/*antagonists & inhibitors
Inflammation/*prevention & control
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Animals ; Antioxidants/pharmacology ; Aorta/metabolism ; Aorta/pathology ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Disease Models, Animal ; Inflammasomes/genetics ; Inflammasomes/metabolism ; Inflammation/metabolism ; Inflammation/pathology ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Interleukin-1/metabolism ; Interleukin-18/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Vascular Cell Adhesion Molecule-1/genetics ; Vascular Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł :
The Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials.
Autorzy :
Tomani JCD; School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, P.O. Box 3286 Kigali, Rwanda.; Department of Molecular Biology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Kagisha V; School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, P.O. Box 3286 Kigali, Rwanda.; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.
Tchinda AT; Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé P.O. Box 6163, Cameroon.
Jansen O; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.
Ledoux A; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.
Vanhamme L; Department of Molecular Biology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Frederich M; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.
Muganga R; School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, P.O. Box 3286 Kigali, Rwanda.
Souopgui J; Department of Molecular Biology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, 6041 Gosselies, Belgium.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 14; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Hibiscus/*chemistry
Inflammasomes/*drug effects
Inflammation/*drug therapy
Interleukin-6/*antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Plant Extracts/*pharmacology
Animals ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-6/metabolism ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
Autorzy :
Lonnemann N; Department of Cellular Neurobiology, Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany.
Hosseini S; Department of Cellular Neurobiology, Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany.; Neuroinflammation and Neurodegeneration Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Marchetti C; Department of Medicine, University of Colorado, Denver, Aurora, CO 80045.
Skouras DB; R&D Division, Olatec Therapeutics, New York, NY 10065.
Stefanoni D; Department of Biochemistry and Molecular Genetics, University of Colorado, Denver, Aurora, CO 80045.
D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado, Denver, Aurora, CO 80045.
Dinarello CA; Department of Medicine, University of Colorado, Denver, Aurora, CO 80045; .; Department of Medicine, Radboud University, Medical Center, 6525 Nijmegen, The Netherlands.
Korte M; Department of Cellular Neurobiology, Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany; .; Neuroinflammation and Neurodegeneration Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 15; Vol. 117 (50), pp. 32145-32154. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*complications
Cognitive Dysfunction/*drug therapy
Inflammasomes/*antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Nitriles/*pharmacology
Administration, Oral ; Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/immunology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Behavior Observation Techniques ; Behavior, Animal/drug effects ; Cerebral Cortex/drug effects ; Cerebral Cortex/immunology ; Cerebral Cortex/pathology ; Cognitive Dysfunction/immunology ; Cognitive Dysfunction/pathology ; Disease Models, Animal ; Humans ; Inflammasomes/immunology ; Male ; Mice ; Mice, Transgenic ; Microglia/drug effects ; Microglia/immunology ; Microglia/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/immunology ; Nitriles/therapeutic use ; Presenilin-1/genetics ; Spatial Memory/drug effects
Czasopismo naukowe
Tytuł :
The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy.
Autorzy :
Ghoneim ME; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Sadat City (USC), Menoufia, Egypt. Electronic address: .
Abdallah DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini Str., 11562 Cairo, Egypt. Electronic address: .
Shebl AM; Department of Pathology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
El-Abhar HS; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt (FUE), 11835 Cairo, Egypt.
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Dec 15; Vol. 409, pp. 115309. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Artesunate/*pharmacology
Inflammasomes/*deficiency
Liver/*drug effects
Liver Diseases/*drug therapy
Oxidative Stress/*drug effects
Reperfusion Injury/*drug therapy
Animals ; Apoptosis/drug effects ; Cytokines/metabolism ; Inflammasomes/metabolism ; Inflammation/metabolism ; Liver/metabolism ; Liver Diseases/metabolism ; Male ; Rats ; Rats, Wistar ; Reperfusion Injury/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Characterizing caspase-1 involvement during esophageal disease progression.
Autorzy :
Barber G; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.
Anand A; Department of Internal Medicine, Technical University of Munich, Munich, Germany.
Katarzyna Oficjalska; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Phelan JJ; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.
Heeran AB; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.
Flis E; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Clarke NE; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.
Watson JA; Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin 9, Ireland.
Strangmann J; Department of Internal Medicine, Technical University of Munich, Munich, Germany.
Flood B; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
O'Neill H; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.
O'Toole D; National Oesophageal and Gastric Centre, St. James's Hospital, Dublin 8, Ireland.
MacCarthy F; National Oesophageal and Gastric Centre, St. James's Hospital, Dublin 8, Ireland.
Ravi N; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.; National Oesophageal and Gastric Centre, St. James's Hospital, Dublin 8, Ireland.
Reynolds JV; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.; National Oesophageal and Gastric Centre, St. James's Hospital, Dublin 8, Ireland.
Kay EW; Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin 9, Ireland.
Quante M; Department of Internal Medicine, Technical University of Munich, Munich, Germany.
O'Sullivan J; Department of Surgery, Trinity Translational Medicine Institute, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland. .
Creagh EM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Dec; Vol. 69 (12), pp. 2635-2649. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*immunology
Barrett Esophagus/*immunology
Caspase 1/*metabolism
Esophageal Mucosa/*pathology
Esophageal Neoplasms/*immunology
Inflammasomes/*immunology
Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Animals ; Barrett Esophagus/genetics ; Barrett Esophagus/pathology ; Biopsy ; Caspase 1/immunology ; Caspase Inhibitors/pharmacology ; Cell Line, Tumor ; Cells, Cultured ; Chemokine CXCL1/metabolism ; Disease Models, Animal ; Disease Progression ; Esophageal Mucosa/cytology ; Esophageal Mucosa/immunology ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagectomy ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Inflammasomes/metabolism ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Primary Cell Culture ; Signal Transduction/drug effects ; Signal Transduction/immunology
SCR Disease Name :
Adenocarcinoma Of Esophagus
Czasopismo naukowe
Tytuł :
Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes.
Autorzy :
Weng Z; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Xu C; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Zhang X; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Pang L; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Xu J; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China; Department of Maternal, Child, and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Liu Q; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Zhang L; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Xu S; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Gu A; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of the Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2020 Dec; Vol. 267, pp. 115655. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammasomes*
NLR Family, Pyrin Domain-Containing 3 Protein*/genetics
Animals ; Autophagy ; Caprylates ; Fluorocarbons ; Hepatocytes ; Humans ; Lipid Metabolism ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells.
Autorzy :
Jiao P; Department of Emergency, Shangqiu First people's Hospital, Shangqiu, Henan, China.
Li W; The Third Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
Shen L; Department of Emergency, Shangqiu First people's Hospital, Shangqiu, Henan, China.
Li Y; Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei, China.
Yu L; Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei, China.
Liu Z; Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 687-694.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammasomes/*drug effects
Lipopolysaccharides/*pharmacology
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Sirtuin 1/*metabolism
Theophylline/*analogs & derivatives
Carrier Proteins/metabolism ; Cell Line ; Dinoprostone/metabolism ; Epithelial Cells ; Humans ; Inflammasomes/metabolism ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; NADPH Oxidases/metabolism ; Nitric Oxide/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Sirtuin 1/genetics ; Theophylline/pharmacology
Czasopismo naukowe
Tytuł :
Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway.
Autorzy :
Nyandwi JB; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Pharmacy, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali 4285, Rwanda.
Ko YS; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Jin H; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Yun SP; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea.
Park SW; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea.
Kim HJ; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114246. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carrier Proteins/*metabolism
Cinnamates/*pharmacology
Depsides/*pharmacology
Forkhead Box Protein O1/*metabolism
Glucose/*toxicity
Inflammasomes/*metabolism
Lipoproteins, LDL/*toxicity
p38 Mitogen-Activated Protein Kinases/*metabolism
Antioxidants/pharmacology ; Carrier Proteins/antagonists & inhibitors ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Forkhead Box Protein O1/antagonists & inhibitors ; Humans ; Inflammasomes/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe

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