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Wyszukujesz frazę ""Inflammasomes"" wg kryterium: Temat


Tytuł:
Targeting inflammasomes and pyroptosis in retinal diseases-molecular mechanisms and future perspectives.
Autorzy:
Sun Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.
Li F; Eye Center, Zhongshan City People's Hospital, Zhongshan, 528403, China.
Liu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.
Qiao D; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.
Yao X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.
Liu GS; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, 3002, Australia; Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, VIC, 3002, Australia.
Li D; Department of Ophthalmology, Baylor College of Medicine, Houston, TX, 77030, USA.
Xiao C; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.
Wang T; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Guangming District, Shenzhen, 518132, China; School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao You'anMen Street, Beijing, 100069, China.
Chi W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China. Electronic address: .
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Źródło:
Progress in retinal and eye research [Prog Retin Eye Res] 2024 Jul; Vol. 101, pp. 101263. Date of Electronic Publication: 2024 Apr 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Pyroptosis*/physiology
Inflammasomes*/physiology
Inflammasomes*/metabolism
Retinal Diseases*/metabolism
Retinal Diseases*/drug therapy
Immunity, Innate*/physiology
Humans ; Animals
Czasopismo naukowe
Tytuł:
Elucidating the molecular landscape of tendinitis: the role of inflammasome-related genes and immune interactions.
Autorzy:
Xu H; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lu X; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Yu Y; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhou Y; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Qi T; Department of Neurosurgery, Trauma Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Zheng Y; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
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Źródło:
Frontiers in immunology [Front Immunol] 2024 Jun 11; Vol. 15, pp. 1393851. Date of Electronic Publication: 2024 Jun 11 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Inflammasomes*/genetics
Inflammasomes*/metabolism
Inflammasomes*/immunology
Tendinopathy*/genetics
Tendinopathy*/immunology
Humans ; Computational Biology/methods ; Gene Expression Profiling ; Pyrin/genetics ; NLR Proteins/genetics ; Gene Expression Regulation ; Transcriptome ; Gene Regulatory Networks
Czasopismo naukowe
Tytuł:
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury.
Autorzy:
Tanaka S; Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Noda T; Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Urashima K; Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Ijiri Y; Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Kohda Y; Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Kato R; Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan.
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Źródło:
Journal of applied toxicology : JAT [J Appl Toxicol] 2024 Jun; Vol. 44 (6), pp. 846-852. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Fluoroquinolones*/toxicity
Chemical and Drug Induced Liver Injury*/metabolism
Naphthyridines*/toxicity
Naphthyridines*/pharmacology
Humans ; THP-1 Cells ; Anti-Bacterial Agents/toxicity ; Cell Line, Tumor ; Interleukin-1beta/metabolism
Czasopismo naukowe
Tytuł:
Sulforaphane decreases oxidative stress and inhibits NLRP3 inflammasome activation in a mouse model of ulcerative colitis.
Autorzy:
Zhou ZJ; Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, China.
Dong JY; Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, China.
Qiu Y; Dalian Medical University, Dalian, Liaoning 116044, China.
Zhang GL; Dalian Medical University, Dalian, Liaoning 116044, China.
Wei K; Dalian Medical University, Dalian, Liaoning 116044, China.
He LH; Dalian Medical University, Dalian, Liaoning 116044, China.
Sun YN; Dalian Medical University, Dalian, Liaoning 116044, China.
Jiang HZ; Dalian Medical University, Dalian, Liaoning 116044, China.
Zhang SS; Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, China.
Guo XR; Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, China.
Wang JY; Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, China. Electronic address: .
Chen DP; Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, China. Electronic address: .
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Jun; Vol. 175, pp. 116706. Date of Electronic Publication: 2024 May 06.
Typ publikacji:
Journal Article
MeSH Terms:
Isothiocyanates*/pharmacology
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Sulfoxides*/pharmacology
Oxidative Stress*/drug effects
Colitis, Ulcerative*/drug therapy
Colitis, Ulcerative*/metabolism
Colitis, Ulcerative*/pathology
Colitis, Ulcerative*/chemically induced
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Disease Models, Animal*
Mice, Inbred C57BL*
Animals ; Mice ; Male ; Dextran Sulfate ; Colon/drug effects ; Colon/pathology ; Colon/metabolism ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł:
Molecular regulation of NLRP3 inflammasome activation during parasitic infection.
Autorzy:
Alonaizan R; Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
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Źródło:
Bioscience reports [Biosci Rep] 2024 May 29; Vol. 44 (5).
Typ publikacji:
Journal Article; Review
MeSH Terms:
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*/immunology
Inflammasomes*/metabolism
Inflammasomes*/immunology
Humans ; Animals ; Parasitic Diseases/immunology ; Parasitic Diseases/parasitology ; Parasitic Diseases/metabolism ; Immunity, Innate
Czasopismo naukowe
Tytuł:
An Alkaline Nanocage Continuously Activates Inflammasomes by Disrupting Multiorganelle Homeostasis for Efficient Pyroptosis.
Autorzy:
Song A; State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
Wang W; State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
Wang H; State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
Ji Y; State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
Zhang Y; State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
Ren J; State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
Qu X; State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
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Źródło:
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 May 15; Vol. 16 (19), pp. 24295-24307. Date of Electronic Publication: 2024 May 02.
Typ publikacji:
Journal Article
MeSH Terms:
Pyroptosis*/drug effects
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Homeostasis*/drug effects
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Humans ; Mice ; Bortezomib/pharmacology ; Bortezomib/chemistry ; Liposomes/chemistry ; Animals ; Lysosomes/metabolism ; Lysosomes/drug effects ; Hydroxides/chemistry ; Hydroxides/pharmacology ; Nanostructures/chemistry ; Nanoparticles/chemistry
Czasopismo naukowe
Tytuł:
Inflammasome-related gene signatures as prognostic biomarkers in osteosarcoma.
Autorzy:
Zhang N; Department of Medical Oncology, China Coast Guard Hospital of the People's Armed Police Force, Zhejiang, China.
Han Y; Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Zhejiang, China.
Cao H; Department of Orthopaedic Surgery, China Coast Guard Hospital of the People's Armed Police, Zhejiang, China.
Wang Q; Department of Orthopaedic Surgery, China Coast Guard Hospital of the People's Armed Police, Zhejiang, China.
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Źródło:
Journal of cellular and molecular medicine [J Cell Mol Med] 2024 May; Vol. 28 (9), pp. e18286.
Typ publikacji:
Journal Article
MeSH Terms:
Osteosarcoma*/genetics
Osteosarcoma*/pathology
Osteosarcoma*/immunology
Osteosarcoma*/mortality
Inflammasomes*/metabolism
Inflammasomes*/genetics
Biomarkers, Tumor*/genetics
Gene Expression Regulation, Neoplastic*
Bone Neoplasms*/genetics
Bone Neoplasms*/pathology
Bone Neoplasms*/mortality
Bone Neoplasms*/immunology
Bone Neoplasms*/diagnosis
Humans ; Prognosis ; Gene Expression Profiling ; Female ; Male ; Transcriptome/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Adolescent ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism
Czasopismo naukowe
Tytuł:
Emerging insights into the role of NLRP3 inflammasome and endoplasmic reticulum stress in renal diseases.
Autorzy:
Zhang Y; Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; School of Clinical Medicine, Henan University, Kaifeng, Henan 475004, China.
Guo S; School of Clinical Medicine, Henan University, Kaifeng, Henan 475004, China.
Fu X; Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Zhang Q; School of Clinical Medicine, Henan University, Kaifeng, Henan 475004, China.
Wang H; Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Jul 30; Vol. 136, pp. 112342. Date of Electronic Publication: 2024 May 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Endoplasmic Reticulum Stress*/immunology
Kidney Diseases*/immunology
Kidney Diseases*/metabolism
Inflammasomes*/metabolism
Inflammasomes*/immunology
Humans ; Animals ; Unfolded Protein Response/immunology
Czasopismo naukowe
Tytuł:
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Autorzy:
Li L; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Xu S; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Wang W; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Li X; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Wang H; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Yang Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Wang C; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Gu J; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Luo H; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Meng Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China. Electronic address: .
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Źródło:
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Jul 25; Vol. 130, pp. 155693. Date of Electronic Publication: 2024 May 07.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Cytoplasmic and Nuclear*/metabolism
Liver Diseases, Alcoholic*/drug therapy
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Mice, Inbred C57BL*
Animals ; Male ; Mice ; Disease Models, Animal ; Liver/drug effects ; Liver/pathology ; Liver/metabolism ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Ethanol
Czasopismo naukowe
Tytuł:
Ursolic acid alleviates lupus nephritis by suppressing SUMO1-mediated stabilization of NLRP3.
Autorzy:
Chen L; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Li F; Dermatology Department Huashan Hospital, Fudan University, Shanghai, China.
Ni JH; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Hao YX; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Feng G; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Shen XY; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China; Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Minhang Hospital, Fudan University, Shanghai, China. Electronic address: .
You Y; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China; Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Minhang Hospital, Fudan University, Shanghai, China. Electronic address: .
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Źródło:
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Jul 25; Vol. 130, pp. 155556. Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Triterpenes*/pharmacology
Lupus Nephritis*/drug therapy
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Mice, Inbred MRL lpr*
Ursolic Acid*
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Animals ; Mice ; Disease Models, Animal ; Female ; Mesangial Cells/drug effects ; Mesangial Cells/metabolism ; Anti-Inflammatory Agents/pharmacology ; Sumoylation/drug effects
Czasopismo naukowe
Tytuł:
Total synthesis/semi-synthesis of natural isopentenyl flavonoids with inhibitory activity on NLRP3 inflammasome.
Autorzy:
Hu Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Su M; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Kong Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
Jiang C; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
Yuan Y; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, TX 78229, USA.
Chen X; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. Electronic address: .
Ma L; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Jul 15; Vol. 107, pp. 129777. Date of Electronic Publication: 2024 Apr 29.
Typ publikacji:
Journal Article
MeSH Terms:
NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Flavonoids*/pharmacology
Flavonoids*/chemistry
Flavonoids*/chemical synthesis
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Structure-Activity Relationship ; Molecular Structure ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Animals ; Biological Products/pharmacology ; Biological Products/chemistry ; Biological Products/chemical synthesis ; Mice ; Dose-Response Relationship, Drug ; Humans
Czasopismo naukowe
Tytuł:
Unmasking the NLRP3 inflammasome in dendritic cells as a potential therapeutic target for autoimmunity, cancer, and infectious conditions.
Autorzy:
Alipour S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mardi A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Shajari N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Kazemi T; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Sadeghi MR; Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Ahmadian Heris J; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Masoumi J; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2024 Jul 01; Vol. 348, pp. 122686. Date of Electronic Publication: 2024 May 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Dendritic Cells*/immunology
Dendritic Cells*/metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*/immunology
Neoplasms*/immunology
Neoplasms*/therapy
Inflammasomes*/immunology
Inflammasomes*/metabolism
Autoimmunity*/immunology
Autoimmune Diseases*/immunology
Autoimmune Diseases*/therapy
Autoimmune Diseases*/metabolism
Humans ; Animals ; Communicable Diseases/immunology ; Communicable Diseases/metabolism ; Communicable Diseases/therapy
Czasopismo naukowe
Tytuł:
Resveratrol alleviates acute lung injury in mice by promoting Pink1/Parkin-related mitophagy and inhibiting NLRP3 inflammasome activation.
Autorzy:
Wu D; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhang H; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Li F; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Liu S; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Wang Y; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhang Z; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Wang J; School of Basic Medical Science, Zhengzhou University, Zhengzhou, Henan, China.
Wu Q; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: .
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Źródło:
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2024 Jul; Vol. 1868 (7), pp. 130612. Date of Electronic Publication: 2024 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Lung Injury*/drug therapy
Acute Lung Injury*/metabolism
Acute Lung Injury*/pathology
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Mitophagy*/drug effects
Resveratrol*/pharmacology
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Ubiquitin-Protein Ligases*/metabolism
Protein Kinases*/metabolism
Animals ; Mice ; Male ; Mice, Inbred C57BL ; Lipopolysaccharides ; Bronchoalveolar Lavage Fluid/chemistry
Czasopismo naukowe
Tytuł:
Fisetin-loaded chitosan nanoparticles ameliorate pilocarpine-induced temporal lobe epilepsy and associated neurobehavioral alterations in mice: Role of ROS/TNF-α-NLRP3 inflammasomes pathway.
Autorzy:
Mahawar S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, Kamrup, Assam 781101, India.
Rakshit D; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, Kamrup, Assam 781101, India.
Patel I; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, Kamrup, Assam 781101, India.
Gore SK; Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, Kamrup, Assam 781101, India.
Sen S; Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, Kamrup, Assam 781101, India.
Ranjan OP; Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, Kamrup, Assam 781101, India. Electronic address: .
Mishra A; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari, Kamrup, Assam 781101, India. Electronic address: .
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Źródło:
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2024 Jul; Vol. 59, pp. 102752. Date of Electronic Publication: 2024 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Epilepsy, Temporal Lobe*/drug therapy
Epilepsy, Temporal Lobe*/chemically induced
Epilepsy, Temporal Lobe*/pathology
Epilepsy, Temporal Lobe*/metabolism
Chitosan*/chemistry
Chitosan*/pharmacology
Flavonols*/pharmacology
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Pilocarpine*
Nanoparticles*/chemistry
Reactive Oxygen Species*/metabolism
Tumor Necrosis Factor-alpha*/metabolism
Animals ; Mice ; Male ; Flavonoids/pharmacology ; Flavonoids/administration & dosage ; Behavior, Animal/drug effects ; Anticonvulsants/pharmacology ; Neuroprotective Agents/pharmacology
Czasopismo naukowe
Tytuł:
Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation.
Autorzy:
Li X; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China. Electronic address: .
Yao M; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Li L; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Ma H; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Sun Y; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Lu X; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, PR China.
Jing W; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Nie S; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, PR China.
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Źródło:
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Jul; Vol. 129, pp. 155578. Date of Electronic Publication: 2024 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Pyroptosis*/drug effects
Reperfusion Injury*/drug therapy
Microglia*/drug effects
Inflammasomes*/drug effects
Inflammasomes*/metabolism
Anthraquinones*/pharmacology
Animals ; Male ; Mice ; Infarction, Middle Cerebral Artery/drug therapy ; Mice, Inbred C57BL ; Disease Models, Animal ; Brain Ischemia/drug therapy ; Neuroprotective Agents/pharmacology ; Rats, Sprague-Dawley ; Furans/pharmacology ; Cell Line
Czasopismo naukowe
Tytuł:
Modified Danzhi XiaoyaoSan inhibits neuroinflammation via regulating TRIM31/NLRP3 inflammasome in the treatment of CUMS depression.
Autorzy:
Wang B; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Tian L; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Wu M; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Zhang D; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Yan X; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Bai M; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Li Y; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Su P; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China. Electronic address: .
Xu E; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, PR China; College of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, PR China. Electronic address: .
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Źródło:
Experimental gerontology [Exp Gerontol] 2024 Jul; Vol. 192, pp. 112451. Date of Electronic Publication: 2024 May 09.
Typ publikacji:
Journal Article
MeSH Terms:
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
Ubiquitin-Protein Ligases*/metabolism
Tripartite Motif Proteins*/metabolism
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Depression*/drug therapy
Depression*/metabolism
Rats, Sprague-Dawley*
Antidepressive Agents*/pharmacology
Antidepressive Agents*/therapeutic use
Stress, Psychological*/complications
Stress, Psychological*/drug therapy
Animals ; Male ; Rats ; Disease Models, Animal ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Neuroinflammatory Diseases/drug therapy ; Neuroinflammatory Diseases/metabolism ; Behavior, Animal/drug effects
Czasopismo naukowe
Tytuł:
BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy.
Autorzy:
Liu Q; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhao JN; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Fang ZT; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang X; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
Zhang BG; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
He Y; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Liu RJ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chen J; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: .
Liu GP; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China. Electronic address: .
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Źródło:
Brain, behavior, and immunity [Brain Behav Immun] 2024 Jul; Vol. 119, pp. 648-664. Date of Electronic Publication: 2024 Apr 25.
Typ publikacji:
Journal Article
MeSH Terms:
Mitophagy*/drug effects
Lipopolysaccharides*
Inflammasomes*/metabolism
Inflammasomes*/drug effects
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Depression*/metabolism
Depression*/drug therapy
Mitochondria*/metabolism
Mitochondria*/drug effects
Animals ; Mice ; Male ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism ; Disease Models, Animal ; Depressive Disorder, Major/metabolism ; Inflammation/metabolism ; Behavior, Animal/drug effects ; Protein Kinases/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Neurons/metabolism ; Neurons/drug effects ; Brain/metabolism ; Brain/drug effects ; Apoptosis/drug effects ; Furans ; Indenes ; Sulfonamides
Czasopismo naukowe
Tytuł:
Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non-alcoholic fatty liver disease.
Autorzy:
Hu X; Department of Gastroenterology, Yangzhou Key Laboratory for Precision Treatment of Refractory Bowel Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, China.
Hu C; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, China.
Liao L; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, China.
Zhang H; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, China.
Xu X; Department of Gastroenterology, Yangzhou Key Laboratory for Precision Treatment of Refractory Bowel Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Xiang J; Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, China.
Lu G; Department of Gastroenterology, Yangzhou Key Laboratory for Precision Treatment of Refractory Bowel Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.; Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Jia X; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, China.
Xu H; Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Yangzhou University, Kunshan, China.
Gong W; Department of Gastroenterology, Yangzhou Key Laboratory for Precision Treatment of Refractory Bowel Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, China.; Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, China.
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Źródło:
Scandinavian journal of immunology [Scand J Immunol] 2024 Jul; Vol. 100 (1), pp. e13371. Date of Electronic Publication: 2024 Apr 26.
Typ publikacji:
Journal Article
MeSH Terms:
Syk Kinase*/metabolism
Chalcones*/pharmacology
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Macrophages*/immunology
Macrophages*/metabolism
Macrophages*/drug effects
Non-alcoholic Fatty Liver Disease*/drug therapy
Non-alcoholic Fatty Liver Disease*/metabolism
Non-alcoholic Fatty Liver Disease*/immunology
Mice, Transgenic*
Animals ; Mice ; Macrophage Activation/drug effects ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Male ; Phosphorylation ; Disease Models, Animal
Czasopismo naukowe
Tytuł:
Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ.
Autorzy:
Rodrigues FDS; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: .
Newton WR; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom; MRC Centre for Medical Mycology, Exeter University, Exeter, United Kingdom. Electronic address: .
Tassinari ID; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom; Graduate Program in Physiology, Institute of Basic Health Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: .
da Cunha Xavier FH; Thymus Research Laboratory, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: .
Marx A; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: .
de Fraga LS; Graduate Program in Physiology, Institute of Basic Health Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: .
Wright K; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: .
Guedes RP; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: .
Bambini-Jr V; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: .
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Źródło:
Neurochemistry international [Neurochem Int] 2024 Jul; Vol. 177, pp. 105769. Date of Electronic Publication: 2024 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
PPAR gamma*/metabolism
Microglia*/drug effects
Microglia*/metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors
Cannabidiol*/pharmacology
Nitric Oxide Synthase Type II*/metabolism
Lipopolysaccharides*/toxicity
Receptor, Cannabinoid, CB2*/metabolism
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Inflammation*/metabolism
Inflammation*/drug therapy
Inflammation*/chemically induced
Inflammation*/prevention & control
Animals ; Mice ; Cell Line ; Anti-Inflammatory Agents/pharmacology
Czasopismo naukowe
Tytuł:
Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice.
Autorzy:
Antar SA; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA 24016, USA; Department of Pharmacology, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt.
Abdo W; Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33511, Egypt.
Helal AI; Department of Histology and Cell Biology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh 33511, Egypt.
Abduh MS; Immune Responses in Different Diseases Research Group, Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Hakami ZH; Medical Laboratory Technology Department, College of Applied Medical Sciences, Jazan University, Jazan 82817, Saudi Arabia.
Germoush MO; Biology Department, College of Science, Jouf University, Sakakah 72388, Saudi Arabia.
Alsulimani A; Medical Laboratory Technology Department, College of Applied Medical Sciences, Jazan University, Jazan 82817, Saudi Arabia.
Al-Noshokaty TM; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
El-Dessouki AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, 6th of October, Giza 12566, Egypt.
ElMahdy MK; Department of Pharmacology, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt.
Elgebaly HA; Biology Department, College of Science, Jouf University, Sakakah 72388, Saudi Arabia.
Al-Karmalawy AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6(th) of October, Giza 12566, Egypt.
Mahmoud AM; Department of Life Sciences, Faculty of Science & Engineering, Manchester Metropolitan University, Manchester M1 5GD, UK; Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2024 Jul 01; Vol. 348, pp. 122688. Date of Electronic Publication: 2024 May 04.
Typ publikacji:
Journal Article
MeSH Terms:
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Ubiquinone*/analogs & derivatives
Ubiquinone*/pharmacology
Oxidative Stress*/drug effects
Cardiotoxicity*/drug therapy
Cardiotoxicity*/metabolism
Cardiotoxicity*/prevention & control
NF-kappa B*/metabolism
Inflammasomes*/metabolism
Inflammasomes*/drug effects
Cadmium*/toxicity
Animals ; Mice ; Male ; Down-Regulation/drug effects ; Antioxidants/pharmacology
Czasopismo naukowe

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