Temat: "Inflammasomes" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Native low-density lipoproteins are priming signals of the NLRP3 inflammasome/interleukin-1β pathway in human adipose tissue and macrophages.
Autorzy:: Bissonnette S; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada.; Montréal Diabetes Research Center (MDRC), Montréal, QC, Canada.
Lamantia V; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada.; Montréal Diabetes Research Center (MDRC), Montréal, QC, Canada.
Ouimet B; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada.
Cyr Y; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada.; Montréal Diabetes Research Center (MDRC), Montréal, QC, Canada.
Devaux M; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada.
Rabasa-Lhoret R; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada.; Montréal Diabetes Research Center (MDRC), Montréal, QC, Canada.
Chrétien M; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada.
Saleh M; Faculty of Medicine, McGill University, Montréal, QC, Canada.; University of Bordeaux, Bordeaux, France.
Faraj M; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. .; Institut de Recherches Cliniques de Montréal (IRCM), Office 1770.2, 110, Avenue Des Pins Ouest, Montréal, QC, H2W 1R7, Canada. .; Montréal Diabetes Research Center (MDRC), Montréal, QC, Canada. .; Faculty of Medicine, McGill University, Montréal, QC, Canada. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 01; Vol. 13 (1), pp. 18848. Date of Electronic Publication: 2023 Nov 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes*/metabolism
Diabetes Mellitus, Type 2*/metabolism
Humans ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Lipoproteins, LDL/pharmacology ; Interleukin-1beta/metabolism ; Macrophages/metabolism ; Apolipoproteins B ; Adipose Tissue, White/metabolism ; Adenosine Triphosphate

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Skocz do pozycji: 2.

Tytuł:: Chlorogenic acid protects against myocardial ischemia-reperfusion injury in mice by inhibiting Lnc Neat1/NLRP3 inflammasome-mediated pyroptosis.
Autorzy:: Chai X; Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Liang Z; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Zhang J; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Ding J; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Zhang Q; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Lv S; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Deng Y; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Zhang R; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China.; Department of Pathophysiology, Guizhou Medical University, Guiyang, China.
Lu D; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550025, China. .; Department of Pathophysiology, Guizhou Medical University, Guiyang, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Oct 18; Vol. 13 (1), pp. 17803. Date of Electronic Publication: 2023 Oct 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes*/metabolism
Myocardial Reperfusion Injury*/drug therapy
Myocardial Reperfusion Injury*/prevention & control
Myocardial Reperfusion Injury*/metabolism
Mice ; Animals ; Pyroptosis ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Chlorogenic Acid/pharmacology ; Chlorogenic Acid/therapeutic use ; Mice, Inbred C57BL ; Hypoxia

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Skocz do pozycji: 3.

Tytuł:: Cardamonin protects against iron overload induced arthritis by attenuating ROS production and NLRP3 inflammasome activation via the SIRT1/p38MAPK signaling pathway.
Autorzy:: Li S; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
He Q; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Chen B; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Zeng J; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Dou X; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Pan Z; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Xiao J; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Li M; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Wang F; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Chen C; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Lin Y; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Wang X; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, , Guangzhou, 510405, People's Republic of China.; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Wang H; Department of Orthopaedics, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun Area, Guangzhou, 510405, People's Republic of China. .
Chen J; Department of Orthopaedics, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun Area, Guangzhou, 510405, People's Republic of China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Aug 23; Vol. 13 (1), pp. 13744. Date of Electronic Publication: 2023 Aug 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes*
Osteoarthritis*/drug therapy
Animals ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species ; Sirtuin 1 ; Signal Transduction ; Iron

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Skocz do pozycji: 4.

Tytuł:: Association between development of severe COVID-19 and a polymorphism in the CIAS1 gene that codes for an inflammasome component.
Autorzy:: Tozetto-Mendoza TR; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. .
Mendes-Correa MC; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Linhares IM; Departamento de Ginecologia e Obstetricia, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
de Cássia Raymundi V; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
de Oliveira Paião HG; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Barbosa EMG; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Luna-Muschi A; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Honorato L; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Correa GF; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
da Costa AC; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Costa SF; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Witkin SS; Laboratório de Virologia LIM 52, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jul 12; Vol. 13 (1), pp. 11252. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: COVID-19*/genetics
Inflammasomes*/genetics
NLR Family, Pyrin Domain-Containing 3 Protein*/genetics
Humans ; Cytokines ; Gene Frequency ; Polymorphism, Genetic

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Skocz do pozycji: 5.

Tytuł:: Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis.
Autorzy:: Pampuscenko K; Neuroscience Institute, Lithuanian University of Health Sciences, 50161, Kaunas, Lithuania. .
Morkuniene R; Neuroscience Institute, Lithuanian University of Health Sciences, 50161, Kaunas, Lithuania.
Krasauskas L; Life Sciences Center, Institute of Biotechnology, Vilnius University, 10257, Vilnius, Lithuania.
Smirnovas V; Life Sciences Center, Institute of Biotechnology, Vilnius University, 10257, Vilnius, Lithuania.
Brown GC; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Borutaite V; Neuroscience Institute, Lithuanian University of Health Sciences, 50161, Kaunas, Lithuania.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jul 04; Vol. 13 (1), pp. 10813. Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes*/metabolism
Tauopathies*/metabolism
Humans ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; tau Proteins/metabolism ; Microglia/metabolism ; Caspase 1/metabolism ; Toll-Like Receptor 4/metabolism ; Neurons/metabolism ; Phagocytosis/physiology ; NADPH Oxidases/metabolism

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Skocz do pozycji: 6.

Tytuł:: LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Autorzy:: Zhang YH; Department of Pathology Changhai Hospital, Second Military Medical University, Shanghai, China.
Sun TT; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Chashan Higher Education Park, Wenzhou, Zhejiang, China.
Liu ZH; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Chashan Higher Education Park, Wenzhou, Zhejiang, China.
Li X; Department of Physiology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Fan XF; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Chashan Higher Education Park, Wenzhou, Zhejiang, China.
Han LP; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Chashan Higher Education Park, Wenzhou, Zhejiang, China. .; Department of Physiology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Apr 01; Vol. 14 (1), pp. 7652. Date of Electronic Publication: 2024 Apr 01.
Typ publikacji:: Journal Article
MeSH Terms:: RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Mice ; Male ; Animals ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Transforming Growth Factor beta1/metabolism ; Isoproterenol/toxicity ; Inflammasomes ; Sirtuin 1/genetics ; Mice, Inbred C57BL ; Fibrosis

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Skocz do pozycji: 7.

Tytuł:: Toxoplasma gondii infection associated with inflammasome activation and neuronal injury.
Autorzy:: Andreou D; Department of Psychiatric Research, Diakonhjemmet Hospital, Forskningsveien 7, 0373, Oslo, Norway. .; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway. .; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. .
Steen NE; Department of Psychiatric Research, Diakonhjemmet Hospital, Forskningsveien 7, 0373, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Mørch-Johnsen L; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatry and Department of Clinical Research, Østfold Hospital, Grålum, Norway.
Jørgensen KN; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Drammen, Norway.
Wortinger LA; Department of Psychiatric Research, Diakonhjemmet Hospital, Forskningsveien 7, 0373, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Barth C; Department of Psychiatric Research, Diakonhjemmet Hospital, Forskningsveien 7, 0373, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Szabo A; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
O'Connell KS; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Lekva T; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Hjell G; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatry and Department of Clinical Research, Østfold Hospital, Grålum, Norway.
Johansen IT; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ormerod MBEG; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Haukvik UK; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Forensic Research and Education, Oslo University Hospital, Oslo, Norway.
Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway.
Yolken RH; Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andreassen OA; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Ueland T; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Agartz I; Department of Psychiatric Research, Diakonhjemmet Hospital, Forskningsveien 7, 0373, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 04; Vol. 14 (1), pp. 5327. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:: Journal Article
MeSH Terms:: Toxoplasma*
Toxoplasmosis*
Humans ; Female ; Adult ; Male ; Inflammasomes ; Interleukin-18 ; Immunoglobulin G

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Skocz do pozycji: 8.

Tytuł:: Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3.
Autorzy:: Lee S; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea.
Ye Q; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea.
Yang H; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea.
Lee S; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea.
Kim Y; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea.
Lee N; Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, 05278, Republic of Korea.
Gonzalez-Cox D; Herbarium of National Autonomous University of Nicaragua at Leon, Leon, 21000, Nicaragua.
Yi DK; International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
Kim SY; International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
Choi S; International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
Choi T; Department of Urology, School of Medicine, Kyung Hee University, Seoul, 05278, Republic of Korea.
Kim MS; Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, 05278, Republic of Korea.
Hong SS; Natural Product Research Team, Gyeonggi Bio-Center, Suwon, Republic of Korea.
Choi CW; Natural Product Research Team, Gyeonggi Bio-Center, Suwon, Republic of Korea. .
Lee Y; Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, 05278, Republic of Korea. .
Park YH; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea. .; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 04; Vol. 14 (1), pp. 5237. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:: Journal Article
MeSH Terms:: NLR Family, Pyrin Domain-Containing 3 Protein*
Lauraceae*
Animals ; Inflammasomes ; Zebrafish ; Inflammation/drug therapy ; Anti-Inflammatory Agents/pharmacology ; Adenosine Triphosphatases ; Plant Extracts/pharmacology

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Skocz do pozycji: 9.

Tytuł:: A pivotal role for the IL-1β and the inflammasome in preterm labor.
Autorzy:: Lopez TE; INSERM U1231, Labex LIPSTIC and Label of Excellence from la Ligue Nationale Contre le Cancer, 21000, Dijon, France.; Faculty of Medicine and Pharmacy, University of Burgundy, 21000, Dijon, France.
Zhang H; INSERM U1231, Labex LIPSTIC and Label of Excellence from la Ligue Nationale Contre le Cancer, 21000, Dijon, France.; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Bouysse E; INSERM U1231, Labex LIPSTIC and Label of Excellence from la Ligue Nationale Contre le Cancer, 21000, Dijon, France.; Faculty of Medicine and Pharmacy, University of Burgundy, 21000, Dijon, France.
Neiers F; Faculty of Medicine and Pharmacy, University of Burgundy, 21000, Dijon, France.
Ye XY; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Garrido C; INSERM U1231, Labex LIPSTIC and Label of Excellence from la Ligue Nationale Contre le Cancer, 21000, Dijon, France.; Faculty of Medicine and Pharmacy, University of Burgundy, 21000, Dijon, France.; Cancer Center George-François Leclerc, 21000, Dijon, France.
Wendremaire M; INSERM U1231, Labex LIPSTIC and Label of Excellence from la Ligue Nationale Contre le Cancer, 21000, Dijon, France.; Faculty of Medicine and Pharmacy, University of Burgundy, 21000, Dijon, France.
Lirussi F; INSERM U1231, Labex LIPSTIC and Label of Excellence from la Ligue Nationale Contre le Cancer, 21000, Dijon, France. .; Laboratory of Pharmacology-Toxicology, Platform PACE, University Hospital Besançon, 25000, Besançon, France. .; Faculty of Medicine and Pharmacy, University of Franche-Comté, 25000, Besançon, France. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 20; Vol. 14 (1), pp. 4234. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:: Journal Article
MeSH Terms:: Labor, Obstetric*
Obstetric Labor, Premature*
Female ; Humans ; Infant, Newborn ; Pregnancy ; Cells, Cultured ; Cytokines/genetics ; Inflammasomes ; Interleukin-1beta/genetics ; Myometrium

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Skocz do pozycji: 10.

Tytuł:: JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation.
Autorzy:: Lee G; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea.
Ahn H; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea.
Yun JH; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea.
Park J; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea.
Lee E; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea.
Oh S; Department of Molecular Medicine, School of Medicine, Ewha Womans University, Gangseo-gu, Seoul, 07804, Republic of Korea.
Lee GS; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Dec 28; Vol. 12 (1), pp. 22484. Date of Electronic Publication: 2022 Dec 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes*/metabolism
Chalcone*/pharmacology
Humans ; Animals ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Macrophages/metabolism ; Caspase 1/metabolism ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism

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Tytuł:: TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.
Autorzy:: Zhang L; Department of Emergency Medicine, Chun'an First People's Hospital, Hangzhou City, Zhejiang Province, China.
Li G; Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Li Y; Department of Special Inspection, Hangzhou TCM Hospital, Affiliated to Zhejiang Chinese Medical University, No. 453, Tiyuchang Road, Hangzhou City, Zhejiang Province, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 30; Vol. 14 (1), pp. 2511. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:: Journal Article
MeSH Terms:: Brain Ischemia*/metabolism
Reperfusion Injury*/metabolism
Stroke*/metabolism
Animals ; Humans ; Rats ; Infarction, Middle Cerebral Artery/drug therapy ; Inflammasomes/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Microglia/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pyroptosis ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/metabolism ; Ubiquitination

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Skocz do pozycji: 12.

Tytuł:: Expression of NLRP3 and AIM2 inflammasome in Peripheral blood in Chinese patients with acute and chronic brucellosis.
Autorzy:: Su X; Tianjin Medical University, Tianjin, China.; Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Zhao S; Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. shigang_.
Song Y; General Medicine Department, Tianjin Medical University General Hospital, Tianjin, China. .; Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin Neurological Institute, Tianjin, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Sep 06; Vol. 12 (1), pp. 15123. Date of Electronic Publication: 2022 Sep 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brucellosis*
Inflammasomes*/metabolism
Caspase 1/metabolism ; China ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Immunity, Innate ; Interleukin-18 ; Interleukin-1beta/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism

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Skocz do pozycji: 13.

Tytuł:: Pinocembrin suppresses oxidized low-density lipoprotein-triggered NLRP3 inflammasome/GSDMD-mediated endothelial cell pyroptosis through an Nrf2-dependent signaling pathway.
Autorzy:: Wang T; College of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong, China.
Tian H; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, No. 4655 Daxue Road, Changqing District, Jinan, 250355, Shandong, China. .; Key Laboratory of Atherosclerosis in Universities of Shandong, Institute of Atherosclerosis, Shandong Academy of Medical Sciences, Shandong First Medical University, Taian, 271000, Shandong, China. .
Pan T; College of Basic Medical Sciences, Shandong Academy of Medical Sciences, Shandong First Medical University, Taian, 271000, Shandong, China.
Yao S; College of Basic Medical Sciences, Shandong Academy of Medical Sciences, Shandong First Medical University, Taian, 271000, Shandong, China.
Yu H; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, No. 4655 Daxue Road, Changqing District, Jinan, 250355, Shandong, China.
Wu Y; Pharmacy Department, Dongying District Hospital of Traditional Chinese Medicine, Dongying, 257000, Shandong, China.
Wang S; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, No. 4655 Daxue Road, Changqing District, Jinan, 250355, Shandong, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Aug 16; Vol. 12 (1), pp. 13885. Date of Electronic Publication: 2022 Aug 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes*/metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Animals ; Mice ; Caspase 1/metabolism ; Endothelial Cells/metabolism ; Flavanones ; Lipoproteins, LDL ; NF-E2-Related Factor 2/metabolism ; Signal Transduction

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Skocz do pozycji: 14.

Tytuł:: Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease.
Autorzy:: Markelić I; Clinic for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Zagreb, Croatia.
Hlapčić I; Department of Medical Biochemistry and Haematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Čeri A; Department of Medical Biochemistry and Haematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Radić Antolic M; Clinical Institute of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
Samaržija M; Clinic for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Zagreb, Croatia.
Popović-Grle S; Clinic for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia.
Vukić Dugac A; Clinic for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia.
Rumora L; Department of Medical Biochemistry and Haematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 May 09; Vol. 12 (1), pp. 7544. Date of Electronic Publication: 2022 May 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes*/metabolism
Pulmonary Disease, Chronic Obstructive*/pathology
Caspase 1 ; Humans ; Inflammation/pathology ; Interleukin-1beta/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism

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Skocz do pozycji: 15.

Tytuł:: Attenuates reactive oxygen species: induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in models of trigeminal neuralgia.
Autorzy:: Liu M; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Wang Y; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Li S; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Hou X; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Li T; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Xu Z; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Chen F; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Zhou Y; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China.
Xia L; Department of Neurosurgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, China. .
Wang W; Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, People's Republic of China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Oct 23; Vol. 13 (1), pp. 18111. Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Pyroptosis*
Trigeminal Neuralgia*
Rats ; Animals ; Reactive Oxygen Species/metabolism ; NF-E2-Related Factor 2/metabolism ; Hydrogen Peroxide/pharmacology ; Signal Transduction ; Caspase 1/metabolism ; RNA, Small Interfering/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Inflammasomes/metabolism

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Skocz do pozycji: 16.

Tytuł:: The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines.
Autorzy:: Nopparat C; Innovative Learning Center, Srinakharinwirot University, Sukhumvit 23, Bangkok, 10110, Thailand.
Boontor A; Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Laksi, Bangkok, Thailand.
Kutpruek S; Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Laksi, Bangkok, Thailand.
Govitrapong P; Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Laksi, Bangkok, Thailand. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Oct 19; Vol. 13 (1), pp. 17841. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Melatonin*/pharmacology
Neuroblastoma*
Alzheimer Disease*/drug therapy
Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Interleukin-18 ; Amyloid beta-Peptides ; Caspase 1/metabolism ; Cell Line ; Inflammation ; Cytokines/metabolism ; Tumor Necrosis Factor-alpha ; Interleukin-1beta/metabolism

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Skocz do pozycji: 17.

Tytuł:: Pyroptosis burden is associated with anti-TNF treatment outcome in inflammatory bowel disease: new insights from bioinformatics analysis.
Autorzy:: Gao X; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China.
Wang C; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China.
Shen XT; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China.
Li CY; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China.
Li YC; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China.
Gao H; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China.
Qian JM; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China. .; Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. .
Zhang XL; Department of GastroenterologyHebei Key Laboratory of GastroenterologyHebei Clinical Research Center for Digestive Diseases, The Second Hospital of Hebei Medical University, Hebei Institute of Gastroenterology, Shijiazhuang, 050035, Hebei, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Sep 22; Vol. 13 (1), pp. 15821. Date of Electronic Publication: 2023 Sep 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tumor Necrosis Factor Inhibitors*
Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/genetics
Humans ; Pyroptosis ; Inflammasomes/genetics ; Treatment Outcome ; Computational Biology

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Skocz do pozycji: 18.

Tytuł:: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Autorzy:: Ambrus-Aikelin G; Jecure Therapeutics, San Diego, CA, USA.
Takeda K; Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Joetham A; Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Lazic M; Jecure Therapeutics, San Diego, CA, USA.
Povero D; Jecure Therapeutics, San Diego, CA, USA. .; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA. .
Santini AM; Jecure Therapeutics, San Diego, CA, USA.
Pranadinata R; Jecure Therapeutics, San Diego, CA, USA.
Johnson CD; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
McGeough MD; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Beasley FC; Jecure Therapeutics, San Diego, CA, USA.
Stansfield R; Jecure Therapeutics, San Diego, CA, USA.
McBride C; Jecure Therapeutics, San Diego, CA, USA.
Trzoss L; Jecure Therapeutics, San Diego, CA, USA.
Hoffman HM; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Feldstein AE; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Stafford JA; Jecure Therapeutics, San Diego, CA, USA.
Veal JM; Jecure Therapeutics, San Diego, CA, USA.
Bain G; Jecure Therapeutics, San Diego, CA, USA.
Gelfand EW; Department of Pediatrics, National Jewish Health, Denver, CO, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Aug 19; Vol. 13 (1), pp. 13524. Date of Electronic Publication: 2023 Aug 19.
Typ publikacji:: Journal Article
MeSH Terms:: Cardiovascular Diseases*
Lupus Nephritis*
Animals ; Mice ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Caspase 1

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Skocz do pozycji: 19.

Tytuł:: Effects of dexmedetomidine on A549 non-small cell lung cancer growth in a clinically relevant surgical xenograft model.
Autorzy:: Jun JH; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Shim JK; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Oh JE; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim KS; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kwak YL; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Soh S; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. .; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Aug 01; Vol. 13 (1), pp. 12471. Date of Electronic Publication: 2023 Aug 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dexmedetomidine*/pharmacology
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Humans ; Mice ; Animals ; Inflammasomes/metabolism ; Interleukin-18/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Interleukin-10 ; Heterografts ; Mice, Nude ; Inflammation/pathology

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Skocz do pozycji: 20.

Tytuł:: Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy.
Autorzy:: Kanno K; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Koseki M; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan. .
Chang J; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Saga A; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Inui H; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Okada T; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tanaka K; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Asaji M; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Zhu Y; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Ide S; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Health Care Division, Health and Counselling Centre, Osaka University, Osaka, Japan.
Saito S; Division of Health Sciences, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan.
Higo T; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Okuzaki D; Genome Information Research Centre, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Ohama T; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Dental Anaesthesiology, Osaka University Graduate School of Dentistry, Osaka, Japan.
Nishida M; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Health Care Division, Health and Counselling Centre, Osaka University, Osaka, Japan.
Kamada Y; Department of Advanced Metabolic Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan.
Ono M; Division of Innovative Medicine for Hepatobiliary and Pancreatology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Saibara T; Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan.
Yamashita S; Department of Cardiology, Rinku General Medical Centre, Osaka, Japan.
Sakata Y; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 22; Vol. 12 (1), pp. 2996. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Benzoxazoles/*pharmacology
Butyrates/*pharmacology
Cardiomyopathies/*etiology
Cardiomyopathies/*metabolism
Inflammasomes/*metabolism
Liver/*metabolism
Myocardium/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Non-alcoholic Fatty Liver Disease/*etiology
Non-alcoholic Fatty Liver Disease/*metabolism
Animals ; Benzoxazoles/administration & dosage ; Butyrates/administration & dosage ; Cardiomyopathies/drug therapy ; Diet, High-Fat/adverse effects ; Dietary Carbohydrates/adverse effects ; Disease Models, Animal ; Gene Expression/drug effects ; Gene Expression/genetics ; Inflammasomes/genetics ; Male ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Non-alcoholic Fatty Liver Disease/drug therapy ; Mice

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