Temat: "Inflammasomes" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Evaluation of the relationship between serum interleukin-1β levels and expression of inflammasome-related genes in patients with COVID-19.
Autorzy:: Bagheri-Hosseinabadi Z; Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.; Department of Clinical Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Shamsizadeh A; Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Bahrehmand F; Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abbasifard M; Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. .; Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. .; Pokaż więcej
Źródło:: BMC immunology [BMC Immunol] 2023 Sep 18; Vol. 24 (1), pp. 30. Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:: Journal Article
MeSH Terms:: COVID-19*
Inflammasomes*
Interleukin-1beta*/blood
Humans ; Apoptosis ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics

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Skocz do pozycji: 2.

Tytuł:: Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity.
Autorzy:: Xing Y; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Wang JY; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Li MY; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Zhang ZH; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Jin HL; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Zuo HX; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Ma J; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Jin X; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2022 May; Vol. 179 (9), pp. 1887-1907. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Caspase 8*/metabolism
Inflammasomes*/drug effects
Inflammasomes*/metabolism
Interleukin-1beta*/antagonists & inhibitors
Interleukin-1beta*/biosynthesis
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Strophanthins*/pharmacology
Animals ; Caspase 1/metabolism ; DNA-Binding Proteins/antagonists & inhibitors ; Mice ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Transcription Factors/antagonists & inhibitors ; Ubiquitination ; Zinc Fingers

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Skocz do pozycji: 3.

Tytuł:: Inflammasome activation and IL-1β signalling in group A Streptococcus disease.
Autorzy:: Richter J; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia.
Brouwer S; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia.
Schroder K; Australian Infectious Diseases Research Centre, Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, Queensland, Australia.
Walker MJ; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia.; Pokaż więcej
Źródło:: Cellular microbiology [Cell Microbiol] 2021 Sep; Vol. 23 (9), pp. e13373. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Inflammasomes*
Interleukin-1beta*
Streptococcal Infections*
Humans ; NLR Family, Pyrin Domain-Containing 3 Protein ; Signal Transduction ; Streptococcus pyogenes

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Skocz do pozycji: 4.

Tytuł:: Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance.
Autorzy:: Américo-Da-Silva L; Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380544, Chile.
Aguilera J; Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380544, Chile.
Quinteros-Waltemath O; Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380544, Chile.
Sánchez-Aguilera P; Centro de Estudios en Ejercicio, Metabolismo y Cáncer, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Russell J; Escuela de Pedagogía en Educación Física, Facultad de Educación, Universidad Autónoma de Chile, Santiago 8900000, Chile.
Cadagan C; Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380544, Chile.
Meneses-Valdés R; Centro de Estudios en Ejercicio, Metabolismo y Cáncer, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Sánchez G; Programa de Fisiopatología, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Estrada M; Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Jorquera G; Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.
Barrientos G; Centro de Estudios en Ejercicio, Metabolismo y Cáncer, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.; Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Llanos P; Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380544, Chile.; Centro de Estudios en Ejercicio, Metabolismo y Cáncer, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 23; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 23.
Typ publikacji:: Journal Article
MeSH Terms:: Glucose Transporter Type 4/*metabolism
Inflammasomes/*metabolism
Insulin Resistance/*physiology
Interleukin-1beta/*metabolism
Muscle, Skeletal/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Animals ; Caspase 1/metabolism ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Furans/pharmacology ; Indenes/pharmacology ; Inflammasomes/chemistry ; Interleukin-1beta/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Obesity/chemically induced ; Obesity/metabolism ; Phosphate-Binding Proteins/metabolism ; Sulfonamides/pharmacology ; Mice

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Skocz do pozycji: 5.

Tytuł:: NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation.
Autorzy:: Ahn H; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Lee G; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Kim J; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Park J; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Kang SG; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Yoon SI; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Lee E; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Lee GS; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Jul 02; Vol. 10 (7). Date of Electronic Publication: 2021 Jul 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes/*immunology
Interleukin-1beta/*immunology
Lipocalin-2/*immunology
Macrophages/*immunology
NLR Family, Pyrin Domain-Containing 3 Protein/*immunology
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Adenosine Triphosphate/pharmacology ; Animals ; Female ; Femur/cytology ; Femur/immunology ; Gene Expression Regulation ; Immunity, Innate ; Inflammasomes/drug effects ; Inflammasomes/genetics ; Interleukin-1beta/genetics ; Lipocalin-2/genetics ; Lipopolysaccharides/pharmacology ; Macrophages/cytology ; Macrophages/drug effects ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Nigericin/pharmacology ; Primary Cell Culture ; RAW 264.7 Cells ; Signal Transduction ; Stem Cells/cytology ; Stem Cells/drug effects ; Stem Cells/immunology ; Tibia/cytology ; Tibia/immunology ; Transcription, Genetic

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Skocz do pozycji: 6.

Tytuł:: Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.
Autorzy:: Triantafilou K; Immunology Catalyst, Immunology Network, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.; Cardiff University, Institute of Infection and Immunity, School of Medicine, University hospital of Wales, Heath Park, Cardiff, United Kingdom.
Ward CJK; Cardiff University, Institute of Infection and Immunity, School of Medicine, University hospital of Wales, Heath Park, Cardiff, United Kingdom.
Czubala M; Cardiff University, Institute of Infection and Immunity, School of Medicine, University hospital of Wales, Heath Park, Cardiff, United Kingdom.
Ferris RG; ViiV Healthcare, Research Triangle Park, North Carolina, United States of America.
Koppe E; Immunology Catalyst, Immunology Network, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.
Haffner C; Medicinal Chemistry, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.
Piguet V; Cardiff University, Institute of Infection and Immunity, School of Medicine, University hospital of Wales, Heath Park, Cardiff, United Kingdom.; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada.; Division of Dermatology, Women's College Hospital, Toronto, Canada.
Patel VK; Medicinal Chemistry, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.
Amrine-Madsen H; ViiV Healthcare, Research Triangle Park, North Carolina, United States of America.
Modis LK; Immunology Catalyst, Immunology Network, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.
Masters SL; Immunology Catalyst, Immunology Network, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.; Inflammation Division, The Walter and Eliza Hall Institute, Victoria, Australia.
Triantafilou M; Immunology Catalyst, Immunology Network, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.; Cardiff University, Institute of Infection and Immunity, School of Medicine, University hospital of Wales, Heath Park, Cardiff, United Kingdom.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2021 Apr 16; Vol. 17 (4), pp. e1009417. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV Infections/*virology
Inflammasomes/*immunology
Interleukin-18/*metabolism
Interleukin-1beta/*metabolism
Macrophages/*virology
Peptide Fragments/*metabolism
Cell Communication/genetics ; Cell Communication/immunology ; Gene Expression/genetics ; Gene Expression/immunology ; HIV Infections/metabolism ; Humans ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Inflammasomes/metabolism ; Macrophages/immunology ; Neuronal Apoptosis-Inhibitory Protein/genetics ; Signal Transduction/immunology

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Skocz do pozycji: 7.

Tytuł:: Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus.
Autorzy:: Li Z; Medical School and Jiangsu Provincial Key Laboratory of Medicine, Nanjing University, Nanjing, China. .; Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China. .
Hu J; Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China.
Bao C; Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China.
Gao C; Medical School and Jiangsu Provincial Key Laboratory of Medicine, Nanjing University, Nanjing, China.
Zhang N; Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China.
Cardona CJ; Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Minnesota at Twin Cities, 300D Veterinary Science Building, 1971 Commonwealth Avenue, Saint Paul, MN, 55108, USA.
Xing Z; Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Minnesota at Twin Cities, 300D Veterinary Science Building, 1971 Commonwealth Avenue, Saint Paul, MN, 55108, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 16; Vol. 12 (1), pp. 2573. Date of Electronic Publication: 2022 Feb 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Virus Replication*
Bunyaviridae Infections/*complications
Inflammasomes/*immunology
Interleukin-1beta/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Phlebovirus/*isolation & purification
Severe Fever with Thrombocytopenia Syndrome/*pathology
Animals ; Bunyaviridae Infections/virology ; Case-Control Studies ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Severe Fever with Thrombocytopenia Syndrome/etiology ; Severe Fever with Thrombocytopenia Syndrome/metabolism

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Skocz do pozycji: 8.

Tytuł:: KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle-Wells syndrome.
Autorzy:: Kaneko N; Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan.
Kurata M; Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan.
Yamamoto T; Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan.
Shigemura T; Department of Pediatrics, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan.
Agematsu K; Department of Pediatrics, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan.; Department of Infectious Immunology, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan.
Yamazaki T; Department of Pediatrics, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan.; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Nishishinjuku 6-7-1, Shinjuku, Tokyo, 160-0023, Japan.
Takeda H; Division of Proteo-Drug-Discovery Sciences, Ehime University Proteo-Science Center, Bunkyocho 3, Matsuyama, Ehime, 790-8577, Japan.
Sawasaki T; Division of Cell-Free Sciences, Ehime University Proteo-Science Center, Bunkyocho 3, Matsuyama, Ehime, 790-8577, Japan.
Koga T; Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan.; Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan.
Kawakami A; Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan.
Yachie A; Division of Medical Safety, Kanazawa University Hospital, Kanazawa, Ishikawa, 920-8641, Japan.
Migita K; Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan.
Yoshiura KI; Department of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4, Nagasaki, 852-8523, Japan.
Urano T; Department of Biochemistry, Shimane University School of Medicine, Izumo, Shimane, 693-8501, Japan.
Masumoto J; Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Aug 11; Vol. 10 (1), pp. 13562. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-Inflammatory Agents/*pharmacology
Cryopyrin-Associated Periodic Syndromes/*drug therapy
Inflammasomes/*drug effects
Interleukin-1beta/*antagonists & inhibitors
Leukocytes, Mononuclear/*drug effects
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Piperidines/*pharmacology
Animals ; Anti-Inflammatory Agents/chemistry ; Case-Control Studies ; Cryopyrin-Associated Periodic Syndromes/metabolism ; Cryopyrin-Associated Periodic Syndromes/pathology ; High-Throughput Screening Assays ; Humans ; Inflammasomes/metabolism ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Male ; Mice ; Piperidines/chemistry

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Skocz do pozycji: 9.

Tytuł:: Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients.
Autorzy:: Zhou X; Department of Pharmacology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Fernando SM; Department of Pharmacology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Pan AY; Department of Pharmacology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Laposa R; Department of Pharmacology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Cullen KR; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN 55454, USA.
Klimes-Dougan B; Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA.
Andreazza AC; Department of Pharmacology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 19; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 19.
Typ publikacji:: Journal Article
MeSH Terms:: CARD Signaling Adaptor Proteins/*blood
Inflammation/*blood
Interleukin-1beta/*blood
Mood Disorders/*blood
NLR Family, Pyrin Domain-Containing 3 Protein/*blood
Adolescent ; Animals ; Apoptosis/genetics ; Caspase 1/blood ; Female ; Humans ; Inflammasomes/blood ; Inflammasomes/genetics ; Inflammation/genetics ; Inflammation/pathology ; Leukocytes, Mononuclear/metabolism ; Male ; Mitochondria/genetics ; Mood Disorders/genetics ; Mood Disorders/pathology

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Skocz do pozycji: 10.

Tytuł:: The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis.
Autorzy:: Mae M; Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Alam MI; Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Yamashita Y; Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Ozaki Y; Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Higuchi K; Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Ziauddin SM; National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Japan.
Montenegro Raudales JL; Department of Oral Anatomy, School of Dentistry, Aichi Gakuin University, 1-100, Kusumoto-cho, Chikusa-ku, Nagoya 464-0851, Japan.
Sakai E; Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Tsukuba T; Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Yoshimura A; Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 18; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 18.
Typ publikacji:: Journal Article
MeSH Terms:: Dental Calculus/*genetics
Interleukin-10/*genetics
Interleukin-18/*genetics
Interleukin-1beta/*genetics
NLR Family, Pyrin Domain-Containing 3 Protein/*genetics
Osteogenesis/*genetics
Alveolar Bone Loss/genetics ; Alveolar Bone Loss/immunology ; Alveolar Bone Loss/pathology ; Animals ; Cell Line ; Culture Media, Conditioned/pharmacology ; Dental Calculus/immunology ; Dental Calculus/pathology ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Inflammasomes/drug effects ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Interleukin-10/immunology ; Interleukin-10/pharmacology ; Interleukin-18/immunology ; Interleukin-18/pharmacology ; Interleukin-1beta/immunology ; Interleukin-1beta/pharmacology ; Macrophage Activation ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/pathology ; Mice ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/deficiency ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Osteoclasts/immunology ; Osteoclasts/pathology ; Osteogenesis/immunology ; Periodontitis/genetics ; Periodontitis/immunology ; Periodontitis/pathology ; Primary Cell Culture ; RANK Ligand/genetics ; RANK Ligand/immunology ; Signal Transduction

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Skocz do pozycji: 11.

Tytuł:: Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
Autorzy:: Orecchioni M; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Kobiyama K; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Winkels H; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Internal Medicine III, Division of Cardiology, Heart Center, University Hospital of Cologne, 50937 Cologne, Germany.
Ghosheh Y; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
McArdle S; Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Mikulski Z; Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Kiosses WB; Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Fan Z; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Immunology, School of Medicine, UConn Health, University of Connecticut, Farmington, CT 06030, USA.
Wen L; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Jung Y; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Roy P; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Ali AJ; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Miyamoto Y; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Mangan M; Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Makings J; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Wang Z; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Denn A; Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Vallejo J; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Owens M; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Durant CP; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Braumann S; Department of Internal Medicine III, Division of Cardiology, Heart Center, University Hospital of Cologne, 50937 Cologne, Germany.
Mader N; Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, 50937 Cologne, Germany.
Li L; Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Matsunami H; Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27708, USA.
Eckmann L; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Latz E; Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Wang Z; Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Hazen SL; Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.; Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Ley K; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Jan 14; Vol. 375 (6577), pp. 214-221. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Aldehydes/*metabolism
Atherosclerosis/*metabolism
Interleukin-1/*metabolism
Interleukin-1beta/*metabolism
Macrophages/*metabolism
Receptors, Odorant/*metabolism
Adult ; Aldehydes/analysis ; Aldehydes/blood ; Aldehydes/pharmacology ; Animals ; Aorta ; Atherosclerosis/drug therapy ; Humans ; Inflammasomes/metabolism ; Interleukin-1alpha/metabolism ; Lipid Peroxidation ; Mice ; Mice, Inbred C57BL ; Middle Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oxidative Stress ; Receptors, Odorant/antagonists & inhibitors ; Receptors, Odorant/genetics ; Signal Transduction

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Skocz do pozycji: 12.

Tytuł:: The role of annexin A1 in the modulation of the NLRP3 inflammasome.
Autorzy:: Galvão I; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
de Carvalho RVH; Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Vago JP; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Silva ALN; Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Carvalho TG; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Antunes MM; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ribeiro FM; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Menezes GB; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Zamboni DS; Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Sousa LP; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Teixeira MM; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Pokaż więcej
Źródło:: Immunology [Immunology] 2020 May; Vol. 160 (1), pp. 78-89. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Annexin A1/*metabolism
Inflammasomes/*immunology
Interleukin-1beta/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Administration, Intranasal ; Animals ; Cartilage, Articular ; Caspase 1/metabolism ; Cells, Cultured ; Disease Models, Animal ; Gout/chemically induced ; Gout/immunology ; Gout/pathology ; Humans ; Inflammasomes/metabolism ; Injections, Intra-Articular ; Lung/immunology ; Lung/pathology ; Macrophages ; Male ; Mice ; Mice, Knockout ; Primary Cell Culture ; Protein Binding/immunology ; Silicon Dioxide/administration & dosage ; Silicon Dioxide/toxicity ; Silicosis/immunology ; Silicosis/pathology ; Transcription, Genetic/immunology ; Uric Acid/administration & dosage ; Uric Acid/toxicity

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Skocz do pozycji: 13.

Tytuł:: FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1β Production.
Autorzy:: Choudhury SM; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Ma X; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Li Y; Department of Animal Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Nian X; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Luo Z; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Ma Y; Department of Animal Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Zhu Z; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Yang F; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Cao W; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Zheng H; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.; Pokaż więcej
Źródło:: Viruses [Viruses] 2021 Dec 23; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Endopeptidases/*metabolism
Foot-and-Mouth Disease/*immunology
Foot-and-Mouth Disease Virus/*metabolism
Interleukin-1beta/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Animals ; Cell Line ; Foot-and-Mouth Disease/virology ; Humans ; Inflammasomes/metabolism ; Ion Channels/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/chemistry ; Protein Domains ; Swine

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Skocz do pozycji: 14.

Tytuł:: Phosphodiesterase-4 Inhibition Reduces Cutaneous Inflammation and IL-1β Expression in a Psoriasiform Mouse Model but Does Not Inhibit Inflammasome Activation.
Autorzy:: Meier-Schiesser B; Department of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Mellett M; Department of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Ramirez-Fort MK; BioFort, P.O. Box 1374, Guaynabo, PR 00970, USA.
Maul JT; Department of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Klug A; Department of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Winkelbeiner N; Department of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Fenini G; Department of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Schafer P; Bristol Myers Squibb, 100 Nassau Park Blvd #300, Princeton, NJ 08540, USA.
Contassot E; Department of Biomedicine, Dermatology Department, Basel University Hospital, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
French LE; Department of Dermatology, Ludwigs-Maximilians-University, Frauenlobstraße 9-11, 80337 Munich, Germany.; Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 28; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 28.
Typ publikacji:: Journal Article
MeSH Terms:: Interleukin-1beta/*metabolism
Phosphodiesterase 4 Inhibitors/*therapeutic use
Psoriasis/*drug therapy
Thalidomide/*analogs & derivatives
Animals ; Drug Evaluation, Preclinical ; Humans ; Immunity, Innate/drug effects ; Inflammasomes/metabolism ; Mice, Transgenic ; Phosphodiesterase 4 Inhibitors/pharmacology ; Psoriasis/metabolism ; Thalidomide/pharmacology ; Thalidomide/therapeutic use

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Skocz do pozycji: 15.

Tytuł:: NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1β response and host susceptibility.
Autorzy:: Wu MF; Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Shu CC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan.
Wang JY; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan.
Yan BS; Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Lai HC; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, and Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan.
Chiang BL; College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Wu LS; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. .
Yu CJ; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. .; College of Medicine, National Taiwan University, Taipei, Taiwan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Aug 29; Vol. 9 (1), pp. 12534. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes/*immunology
Interleukin-1beta/*genetics
Mycobacterium avium Complex/*physiology
Mycobacterium avium-intracellulare Infection/*genetics
NLR Family, Pyrin Domain-Containing 3 Protein/*genetics
Adult ; Female ; Genetic Predisposition to Disease ; Humans ; Inflammasomes/genetics ; Interleukin-1beta/immunology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/microbiology ; Male ; Middle Aged ; Mycobacterium avium-intracellulare Infection/immunology ; Mycobacterium avium-intracellulare Infection/microbiology ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Polymorphism, Single Nucleotide ; Prospective Studies ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/immunology ; Young Adult

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Skocz do pozycji: 16.

Tytuł:: Miltefosine increases macrophage cholesterol release and inhibits NLRP3-inflammasome assembly and IL-1β release.
Autorzy:: Iacano AJ; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA.
Lewis H; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA.
Hazen JE; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA.
Andro H; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA.
Smith JD; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA. .; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, 44195, USA. .
Gulshan K; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Jul 31; Vol. 9 (1), pp. 11128. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Cholesterol/*metabolism
Inflammasomes/*drug effects
Interleukin-1beta/*metabolism
Macrophages/*drug effects
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Phosphorylcholine/*analogs & derivatives
Animals ; Autophagy/drug effects ; Cell Line ; HEK293 Cells ; Humans ; Inflammasomes/metabolism ; Macrophages/metabolism ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Phosphorylation/drug effects ; Phosphorylcholine/pharmacology ; RAW 264.7 Cells ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects

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Skocz do pozycji: 17.

Tytuł:: Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4.
Autorzy:: Chaves MM; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Sinflorio DA; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Thorstenberg ML; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Martins MDA; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Moreira-Souza ACA; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Rangel TP; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Silva CLM; Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Bellio M; Microbiology Institute Paulo de Goés, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Canetti C; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.
Coutinho-Silva R; Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2019 Jun 24; Vol. 15 (6), pp. e1007887. Date of Electronic Publication: 2019 Jun 24 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammasomes/*immunology
Interleukin-1beta/*immunology
Leishmania/*immunology
Leishmaniasis/*immunology
Leukotriene B4/*immunology
Macrophages/*immunology
NLR Family, Pyrin Domain-Containing 3 Protein/*immunology
Receptors, Purinergic P2X7/*immunology
Signal Transduction/*immunology
Animals ; Inflammasomes/genetics ; Interleukin-1beta/genetics ; Leishmaniasis/genetics ; Leishmaniasis/pathology ; Leukotriene B4/genetics ; Macrophages/parasitology ; Mice ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Receptors, Purinergic P2X7/genetics ; Signal Transduction/genetics

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Skocz do pozycji: 18.

Tytuł:: Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2 H -benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor.
Autorzy:: Gastaldi S; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Boscaro V; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Gianquinto E; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Sandall CF; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.
Giorgis M; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Marini E; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Blua F; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Gallicchio M; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Spyrakis F; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
MacDonald JA; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.
Bertinaria M; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Jun 29; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:: Journal Article
MeSH Terms:: Imidazoles*/chemical synthesis
Imidazoles*/chemistry
Imidazoles*/pharmacology
Interleukin-1beta/*metabolism
Macrophages/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Pyroptosis/*drug effects
Humans ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; THP-1 Cells

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Skocz do pozycji: 19.

Tytuł:: NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1β-mediated neuroinflammation.
Autorzy:: Zhang ZT; Department of Hepato-Biliary Surgery, Shenzhen Third People's Hospital, The Second Affiliated Hospital, Southern University of Science and Technology, No.29 Bulan Road, Longgang District, Shenzhen, 518055, China.
Gu XL; Department of Pharmacy, The Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, 450008, China.
Zhao X; Department of Hepato-Biliary Surgery, Shenzhen Third People's Hospital, The Second Affiliated Hospital, Southern University of Science and Technology, No.29 Bulan Road, Longgang District, Shenzhen, 518055, China.
He X; School of Pharmacy, Dali University, Dali, 671000, China.; Fifth Medical Center of PLA General Hospital, Beijing, 100000, China.
Shi HW; Department of Neurosurgery, Hebei Provincial People's Hospital, Shijiazhuang, 050051, China.
Zhang K; Department of Hepato-Biliary Surgery, Shenzhen Third People's Hospital, The Second Affiliated Hospital, Southern University of Science and Technology, No.29 Bulan Road, Longgang District, Shenzhen, 518055, China.
Zhang YM; Department of Hepato-Biliary Surgery, Shenzhen Third People's Hospital, The Second Affiliated Hospital, Southern University of Science and Technology, No.29 Bulan Road, Longgang District, Shenzhen, 518055, China.
Su YN; Department of Hepato-Biliary Surgery, Shenzhen Third People's Hospital, The Second Affiliated Hospital, Southern University of Science and Technology, No.29 Bulan Road, Longgang District, Shenzhen, 518055, China.
Zhu JB; Department of Health Toxicology, Faculty of Navy Medicine, Navy Medical University, Shanghai, 200433, China.
Li ZW; Department of Hepato-Biliary Surgery, Shenzhen Third People's Hospital, The Second Affiliated Hospital, Southern University of Science and Technology, No.29 Bulan Road, Longgang District, Shenzhen, 518055, China. .
Li GB; Department of Lung Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, Southern University of Science and Technology, No.29 Bulan Road, Longgang District, Shenzhen, 518055, China. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2021 Jun 06; Vol. 18 (1), pp. 128. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji:: Journal Article
MeSH Terms:: Brain/*metabolism
Brain/*pathology
Heat Stroke/*complications
Heat Stroke/*physiopathology
Interleukin-1beta/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Neuroinflammatory Diseases/*complications
Neuroinflammatory Diseases/*metabolism
Animals ; Antibodies, Neutralizing/therapeutic use ; Disease Models, Animal ; Heat Stroke/drug therapy ; Heat Stroke/pathology ; Inflammasomes/metabolism ; Interleukin-1beta/immunology ; Lipopolysaccharides ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/deficiency ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Signal Transduction ; Teichoic Acids ; Thermotolerance

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Skocz do pozycji: 20.

Tytuł:: Cytokine secretion and pyroptosis of cholesteatoma keratinocytes mediated by AIM2 inflammasomes in response to cytoplasmic DNA.
Autorzy:: Zhang C; ENT Institute and Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai 200031, P.R. China.
Chen M; ENT Institute and Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai 200031, P.R. China.
Chi Z; ENT Institute and Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai 200031, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 May; Vol. 23 (5). Date of Electronic Publication: 2021 Mar 24.
Typ publikacji:: Journal Article
MeSH Terms:: Bone Neoplasms/*genetics
Cholesteatoma/*genetics
DNA-Binding Proteins/*genetics
Interleukin-18/*genetics
Interleukin-1beta/*genetics
Animals ; Apoptosis/drug effects ; Bone Neoplasms/pathology ; CARD Signaling Adaptor Proteins/genetics ; Caspase 1/genetics ; Cholesteatoma/pathology ; Cytokines/biosynthesis ; Cytokines/genetics ; Cytoplasm/genetics ; DNA/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Inflammasomes/genetics ; Interferon-gamma/genetics ; Interleukin-18/biosynthesis ; Interleukin-1beta/biosynthesis ; Keratinocytes/metabolism ; Neoplasms/genetics ; Neoplasms/pathology ; Poly dA-dT/pharmacology ; Pyroptosis/drug effects ; Pyroptosis/genetics

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