Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Inflammation"" wg kryterium: Temat


Tytuł :
Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice.
Autorzy :
Liong S; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia; .
Oseghale O; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
To EE; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
Brassington K; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
Erlich JR; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
Luong R; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Liong F; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
Brooks R; Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.
Martin C; Discipline of Histopathology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin 2, Ireland.; Sir Patrick Dun's Laboratory, Central Pathology Laboratory, St James's Hospital, Dublin 8, Ireland.; Emer Casey Research Laboratory, Molecular Pathology Laboratory, The Coombe Women and Infants University Hospital, Dublin 8, Ireland.; Irish Cervical Screening Research Consortium (CERVIVA), Trinity College Dublin, Dublin 2, Ireland.
O'Toole S; Discipline of Histopathology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin 2, Ireland.; Sir Patrick Dun's Laboratory, Central Pathology Laboratory, St James's Hospital, Dublin 8, Ireland.; Emer Casey Research Laboratory, Molecular Pathology Laboratory, The Coombe Women and Infants University Hospital, Dublin 8, Ireland.; Irish Cervical Screening Research Consortium (CERVIVA), Trinity College Dublin, Dublin 2, Ireland.
Vinh A; Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne Campus, Bundoora, VIC 3086, Australia.
O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Bozinovski S; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
Vlahos R; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
Papagianis PC; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia.
O'Leary JJ; Discipline of Histopathology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin 2, Ireland.; Sir Patrick Dun's Laboratory, Central Pathology Laboratory, St James's Hospital, Dublin 8, Ireland.; Emer Casey Research Laboratory, Molecular Pathology Laboratory, The Coombe Women and Infants University Hospital, Dublin 8, Ireland.; Irish Cervical Screening Research Consortium (CERVIVA), Trinity College Dublin, Dublin 2, Ireland.
Brooks DA; Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.; Discipline of Histopathology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin 2, Ireland.
Selemidis S; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3083, Australia; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 06; Vol. 117 (40), pp. 24964-24973. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptive Immunity/*genetics
Immunity, Innate/*genetics
Inflammation/*genetics
Influenza A virus/*genetics
Animals ; Blood Vessels/metabolism ; Blood Vessels/pathology ; Female ; Fetus/immunology ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Inflammation/virology ; Influenza A virus/pathogenicity ; Influenza, Human/genetics ; Influenza, Human/immunology ; Influenza, Human/virology ; Membrane Glycoproteins/genetics ; Mice ; Monocytes/metabolism ; Monocytes/pathology ; Placenta/blood supply ; Placenta/immunology ; Placenta/virology ; Pregnancy ; T-Lymphocytes/immunology ; T-Lymphocytes/virology ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 9/genetics
Czasopismo naukowe
Tytuł :
Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.
Autorzy :
Fernandez Lahore G; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden; .
Raposo B; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
Lagerquist M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.
Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.
Sabatier P; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
Xu B; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
Aoun M; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
James J; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
Cai X; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
Zubarev RA; Department of Pharmacological & Technological Chemistry, I. M. Sechenov First Moscow State Medical University, 119146 Moscow, Russia.
Nandakumar KS; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.; Southern Medical University-Karolinska Institute United Medical Inflammation Centre, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Holmdahl R; Division of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden; .; National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi'an, China.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 06; Vol. 117 (40), pp. 24986-24997. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*genetics
Receptors, Calcitriol/*genetics
T-Lymphocytes/*immunology
Animals ; Gene Expression Regulation/genetics ; Humans ; Inflammation/immunology ; Mice ; Polymorphism, Genetic ; T-Lymphocytes/metabolism ; Vitamin D/genetics ; Vitamin D Deficiency/genetics ; Vitamin D Deficiency/immunology
Czasopismo naukowe
Tytuł :
The transition to family caregiving and its effect on biomarkers of inflammation.
Autorzy :
Roth DL; Center on Aging and Health, Johns Hopkins University, Baltimore, MD 21205; .
Haley WE; School of Aging Studies, University of South Florida, Tampa, FL 33620.
Sheehan OC; Center on Aging and Health, Johns Hopkins University, Baltimore, MD 21205.
Huang J; Center on Aging and Health, Johns Hopkins University, Baltimore, MD 21205.
Rhodes JD; School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294.
Durda P; Larner College of Medicine, University of Vermont, Burlington, VT 05401.
Howard VJ; School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294.
Walston JD; Center on Aging and Health, Johns Hopkins University, Baltimore, MD 21205.
Cushman M; Larner College of Medicine, University of Vermont, Burlington, VT 05401.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 14; Vol. 117 (28), pp. 16258-16263. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caregivers/*psychology
Inflammation/*epidemiology
Stress, Psychological/*epidemiology
Aged ; Biomarkers/blood ; Female ; Humans ; Inflammation/blood ; Male ; Middle Aged ; Prospective Studies ; Stress, Psychological/blood ; United States/epidemiology
Czasopismo naukowe
Tytuł :
PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection.
Autorzy :
Tam VC; Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140.
Suen R; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109.
Treuting PM; Department of Comparative Medicine, University of Washington, Seattle, WA 98195.
Armando A; Department of Chemistry and Biochemistry, School of Medicine, University of California San Diego, La Jolla, CA 92093.; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
Lucarelli R; Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140.
Gorrochotegui-Escalante N; Department of Microbiology and Immunology, Temple University, Philadelphia, PA 19140.
Diercks AH; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109.
Quehenberger O; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093.
Dennis EA; Department of Chemistry and Biochemistry, School of Medicine, University of California San Diego, La Jolla, CA 92093.
Aderem A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109.
Gold ES; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 07; Vol. 117 (27), pp. 15789-15798. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Inflammation/*genetics
Influenza, Human/*genetics
PPAR alpha/*genetics
Staphylococcal Infections/*genetics
Superinfection/*genetics
Animals ; Bronchoalveolar Lavage/methods ; Coinfection/genetics ; Coinfection/microbiology ; Coinfection/mortality ; Cytochrome P-450 Enzyme System/genetics ; Disease Models, Animal ; Disease Susceptibility ; Humans ; Inflammation/microbiology ; Inflammation/mortality ; Influenza, Human/microbiology ; Influenza, Human/mortality ; Lung/microbiology ; Lung/pathology ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Mice ; Mice, Knockout ; Necroptosis/genetics ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/mortality ; Superinfection/mortality
Czasopismo naukowe
Tytuł :
Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
Autorzy :
Tan S; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.; University of Chinese Academy of Sciences, 100049 Beijing, China.
Zhao J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.; University of Chinese Academy of Sciences, 100049 Beijing, China.
Sun Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.; University of Chinese Academy of Sciences, 100049 Beijing, China.
Cao S; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Niu K; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Zhong Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Wang H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.; University of Chinese Academy of Sciences, 100049 Beijing, China.
Shi L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Pan H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Hu J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Qian L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Liu N; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China; .
Yuan J; Department of Cell Biology, Harvard Medical School, Boston, MA 02115 .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 23; Vol. 117 (25), pp. 14231-14242. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Hepatocytes/*metabolism
Inflammation/*metabolism
Liver Cirrhosis/*metabolism
Liver Neoplasms/*metabolism
MAP Kinase Kinase Kinases/*metabolism
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Animals ; Biomarkers, Tumor ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Carcinoma, Hepatocellular/genetics ; Cell Death ; Chemokine CCL2/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Hepatocytes/pathology ; Inflammation/pathology ; Liver Cirrhosis/pathology ; Liver Neoplasms/genetics ; MAP Kinase Kinase Kinases/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptors, CCR2/metabolism
Czasopismo naukowe
Tytuł :
Inflammation-related plasma and CSF biomarkers for multiple sclerosis.
Autorzy :
Huang J; Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Khademi M; Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Fugger L; Oxford Centre for Neuroinflammation, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.; Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom.
Lindhe Ö; Olink Proteomics AB, SE-751 83 Uppsala, Sweden.
Novakova L; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Axelsson M; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Malmeström C; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Constantinescu C; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Lycke J; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Piehl F; Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Olsson T; Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Kockum I; Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 09; Vol. 117 (23), pp. 12952-12960. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemokine CCL11/*analysis
Chemokine CCL20/*blood
Inflammation/*immunology
Multiple Sclerosis/*diagnosis
Adult ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Case-Control Studies ; Chemokine CCL11/immunology ; Chemokine CCL20/immunology ; Cohort Studies ; Female ; Humans ; Inflammation/blood ; Inflammation/cerebrospinal fluid ; Male ; Middle Aged ; Multiple Sclerosis/blood ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/immunology ; Prognosis ; Proteomics ; Reproducibility of Results ; Severity of Illness Index ; Young Adult
Czasopismo naukowe
Tytuł :
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways.
Autorzy :
Morianos I; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
Trochoutsou AI; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
Papadopoulou G; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
Semitekolou M; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
Banos A; Division of Immunobiology, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
Konstantopoulos D; Department of Molecular Biology and Genetics, Biomedical Sciences Research Center 'Alexander Fleming', 16672 Athens, Greece.
Manousopoulou A; Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.
Kapasa M; Molecular Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
Wei P; Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Lomenick B; Proteome Exploration Laboratory, Beckman Institute, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Belaidi E; Laboratoire HP2, University Grenoble Alpes, F-38042 Grenoble, France.; INSERM, U1042 Grenoble, France.
Kalamatas T; Department of Neurology, 'G. Gennimatas' General State Hospital of Athens, 115 27 Athens, Greece.
Karageorgiou K; Department of Neurology, Athens Medical Center, 151 25 Athens, Greece.
Doskas T; Department of Neurology, Athens Naval Hospital, 115 21 Athens, Greece.
Sallusto F; Institute of Microbiology, Eidgenössiche Technische Hochschule, 8093 Zürich, Switzerland.
Pan F; Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Garbis SD; Proteome Exploration Laboratory, Beckman Institute, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; The Broad Institute of MIT and Harvard, Boston, MA 02115.
Xanthou G; Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 02; Vol. 117 (22), pp. 12269-12280. Date of Electronic Publication: 2020 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
5'-Nucleotidase/*metabolism
Activins/*pharmacology
Antigens, CD/*metabolism
Apyrase/*metabolism
Encephalomyelitis, Autoimmune, Experimental/*immunology
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Inflammation/*prevention & control
Multiple Sclerosis/*immunology
Th17 Cells/*immunology
Animals ; Cell Differentiation ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Encephalomyelitis, Autoimmune, Experimental/pathology ; GPI-Linked Proteins/metabolism ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Th17 Cells/metabolism
Czasopismo naukowe
Tytuł :
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells.
Autorzy :
Püschel F; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Favaro F; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.; Department of Experimental Immunology, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Lymphoma and Myeloma Center, Cancer Center Amsterdam, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Institute for Infection & Immunity, 1105 AZ Amsterdam, The Netherlands.
Redondo-Pedraza J; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Lucendo E; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Iurlaro R; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Marchetti S; INSERM, Centre Méditerranéen de Médecine Moléculaire, Université Côte d'Azur, 06204 Nice, France.
Majem B; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Eldering E; Department of Experimental Immunology, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Lymphoma and Myeloma Center, Cancer Center Amsterdam, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Institute for Infection & Immunity, 1105 AZ Amsterdam, The Netherlands.
Nadal E; Thoracic Oncology Unit, Department of Medical Oncology, Catalan Institute of Oncology, Hospitalet, 08908 Barcelona, Spain.
Ricci JE; INSERM, Centre Méditerranéen de Médecine Moléculaire, Université Côte d'Azur, 06204 Nice, France.
Chevet E; INSERM U1242 'Chemistry, Oncogenesis, Stress, Signaling,' Université de Rennes, 35042 Rennes, France.; INSERM U1242, Centre de Lutte Contre le Cancer Eugène Marquis, 35042 Rennes, France.
Muñoz-Pinedo C; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain; .; Department of Basic Nursing, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Hospitalet, 08907 Barcelona, Spain.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 05; Vol. 117 (18), pp. 9932-9941. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*genetics
Interleukin-6/*genetics
Interleukin-8/*genetics
Neoplasms/*metabolism
Stress, Physiological/*genetics
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Antimetabolites/pharmacology ; Cell Death/drug effects ; Deoxyglucose/pharmacology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Glucose/metabolism ; Glutamine/metabolism ; HeLa Cells ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Metformin/pharmacology ; NF-kappa B/genetics ; Neoplasms/genetics ; Promoter Regions, Genetic/genetics ; Starvation/genetics ; Starvation/metabolism ; Stress, Physiological/immunology
Czasopismo naukowe
Tytuł :
Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.
Autorzy :
Sedimbi SK; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden; .
Hägglöf T; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.; Department of Microbiology and Immunology, University of Texas School of Medicine Health Science Center at San Antonio, San Antonio, Texas, 78229.
Garimella MG; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Wang S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Duhlin A; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Coelho A; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Ingelshed K; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Mondoc E; Histology Core Facility, Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
Malin SG; Department of Medicine, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden.
Holmdahl R; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Lane DP; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Leadbetter EA; Department of Microbiology and Immunology, University of Texas School of Medicine Health Science Center at San Antonio, San Antonio, Texas, 78229.
Karlsson MCI; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 21; Vol. 117 (16), pp. 9054-9063. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmunity*
Antibodies, Antinuclear/*immunology
Galactosylceramides/*immunology
Inflammation/*immunology
Natural Killer T-Cells/*immunology
Animals ; Antibodies, Antinuclear/blood ; B-Lymphocytes/immunology ; Chronic Disease ; Disease Models, Animal ; Female ; Humans ; Inflammation/blood ; Injections, Intraperitoneal ; Interleukin-18/administration & dosage ; Interleukin-18/immunology ; Male ; Mice ; Mice, Transgenic ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/immunology
Czasopismo naukowe
Tytuł :
Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.
Autorzy :
Welikovitch LA; Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3G 1Y6, Canada.
Do Carmo S; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.
Maglóczky Z; Human Brain Research Laboratory, Institute of Experimental Medicine of the Hungarian Academy of Sciences, 1051 Budapest, Hungary.
Malcolm JC; Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3G 1Y6, Canada.
Lőke J; Department of Psychiatry, Szent Borbála Hospital, 2800 Tatabánya, Hungary.
Klein WL; Department of Neurobiology, Northwestern University, Evanston, IL 60208.
Freund T; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine of the Hungarian Academy of Sciences, 1051 Budapest, Hungary.
Cuello AC; Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3G 1Y6, Canada; .; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.; Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3G 1Y6, Canada.; Department of Pharmacology, University of Oxford, OX1 2JD Oxford, Oxford, United Kingdom.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 24; Vol. 117 (12), pp. 6844-6854. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Brain/*pathology
Inflammation/*pathology
Neurons/*immunology
Plaque, Amyloid/*pathology
Alzheimer Disease/immunology ; Alzheimer Disease/metabolism ; Amyloidosis ; Animals ; Brain/immunology ; Brain/metabolism ; Disease Models, Animal ; Female ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Male ; Neurons/metabolism ; Neurons/pathology ; Plaque, Amyloid/immunology ; Plaque, Amyloid/metabolism ; Rats ; Rats, Transgenic
Czasopismo naukowe
Tytuł :
Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress.
Autorzy :
Wasylishen AR; Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Sun C; Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030.; Genetics and Epigenetics Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030.
Chau GP; Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Qi Y; Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Su X; Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Kim MP; Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Estrella JS; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Lozano G; Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030; .; Genetics and Epigenetics Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 24; Vol. 117 (12), pp. 6622-6629. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeostasis*
Carcinogenesis/*pathology
Inflammation/*pathology
Pancreas, Exocrine/*pathology
Pancreatic Neoplasms/*pathology
Pancreatitis/*pathology
Proto-Oncogene Proteins/*physiology
Animals ; Biomarkers/analysis ; Carcinogenesis/immunology ; Carcinogenesis/metabolism ; Carcinoma, Pancreatic Ductal/immunology ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Differentiation ; Female ; Gene Expression Regulation ; High-Throughput Nucleotide Sequencing ; Inflammation/immunology ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Pancreas, Exocrine/immunology ; Pancreas, Exocrine/metabolism ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/metabolism ; Pancreatitis/chemically induced ; Pancreatitis/immunology ; Pancreatitis/metabolism ; Proto-Oncogene Proteins c-jun/genetics ; Proto-Oncogene Proteins c-jun/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics
Czasopismo naukowe
Tytuł :
CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.
Autorzy :
Slowikowski K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115.
Nguyen HN; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Noss EH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Simmons DP; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Mizoguchi F; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8519 Tokyo, Japan.
Watts GFM; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Gurish MF; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; .
Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; .; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115.; Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health Science Centre, University of Manchester, M13 9PL Manchester, United Kingdom.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 10; Vol. 117 (10), pp. 5532-5541. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Arthritis, Rheumatoid/*metabolism
Fibroblasts/*metabolism
Homeodomain Proteins/*metabolism
Inflammation/*metabolism
Interleukin-17/*physiology
Repressor Proteins/*metabolism
Transcription Factors/*metabolism
Transcriptome/*physiology
Tumor Necrosis Factor-alpha/*physiology
Adaptor Proteins, Signal Transducing/genetics ; Arthritis, Rheumatoid/genetics ; Cells, Cultured ; Chemokine CXCL1/genetics ; Chemokine CXCL2/genetics ; Chemokines, CXC/genetics ; Chemotactic Factors/genetics ; Fibroblasts/drug effects ; Homeodomain Proteins/genetics ; Humans ; Inflammation/genetics ; Interleukin-17/pharmacology ; Interleukin-6/genetics ; Matrix Metalloproteinase 3/metabolism ; Monocytes/drug effects ; Monocytes/physiology ; RNA, Small Interfering/genetics ; Repressor Proteins/genetics ; Stromal Cells/drug effects ; Stromal Cells/metabolism ; Synovial Fluid ; Transcription Factor RelA/metabolism ; Transcription Factors/genetics ; Transcriptome/radiation effects ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Dysregulation of TLR9 in neonates leads to fatal inflammatory disease driven by IFN-γ.
Autorzy :
Stanbery AG; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Newman ZR; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Barton GM; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 11; Vol. 117 (6), pp. 3074-3082. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Autoimmune Diseases/*metabolism
Inflammation/*metabolism
Interferon-gamma/*metabolism
Toll-Like Receptor 9/*metabolism
Animals ; Animals, Newborn ; Autoimmune Diseases/immunology ; Cells, Cultured ; Inflammation/immunology ; Interferon-gamma/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Transgenic ; Monocytes/immunology ; Monocytes/metabolism ; Signal Transduction/immunology ; Toll-Like Receptor 9/genetics ; Toll-Like Receptor 9/immunology
Czasopismo naukowe
Tytuł :
CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness.
Autorzy :
Lago N; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.
Kaufmann FN; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, 88040-900 Santa Catarina, Brazil.
Negro-Demontel ML; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.; Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, 11200 Montevideo, Uruguay.
Alí-Ruiz D; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.
Ghisleni G; Department of Life and Health Sciences, Catholic University of Pelotas, 96015-560 Rio Grande do Sul, Brazil.
Rego N; Bioinformatics Unit, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.
Arcas-García A; Immune Regulation and Immunotherapy Group, CIBBIM-Nanomedicine, Vall d'Hebrón Institut de Recerca, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Vitureira N; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.; Department of Physiology, Facultad de Medicina, Universidad de la República, 11200 Montevideo, Uruguay.
Jansen K; Department of Life and Health Sciences, Catholic University of Pelotas, 96015-560 Rio Grande do Sul, Brazil.
Souza LM; Department of Life and Health Sciences, Catholic University of Pelotas, 96015-560 Rio Grande do Sul, Brazil.
Silva RA; Department of Life and Health Sciences, Catholic University of Pelotas, 96015-560 Rio Grande do Sul, Brazil.
Lara DR; Department of Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, Brazil.
Pannunzio B; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.; Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, 11200 Montevideo, Uruguay.
Abin-Carriquiry JA; Instituto de Investigaciones Biológicas Clemente Estable, 11600 Montevideo, Uruguay.
Amo-Aparicio J; Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Martin-Otal C; Immune Regulation and Immunotherapy Group, CIBBIM-Nanomedicine, Vall d'Hebrón Institut de Recerca, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Naya H; Immune Regulation and Immunotherapy Group, CIBBIM-Nanomedicine, Vall d'Hebrón Institut de Recerca, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
McGavern DB; Viral Immunology and Intravital Imaging Section, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Sayós J; Immune Regulation and Immunotherapy Group, CIBBIM-Nanomedicine, Vall d'Hebrón Institut de Recerca, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
López-Vales R; Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Kaster MP; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, 88040-900 Santa Catarina, Brazil.
Peluffo H; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; .; Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, 11200 Montevideo, Uruguay.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 24; Vol. 117 (12), pp. 6651-6662. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anhedonia*
Polymorphism, Single Nucleotide*
Depressive Disorder, Major/*pathology
Inflammation/*etiology
Microglia/*pathology
Receptors, Immunologic/*genetics
Receptors, Immunologic/*physiology
Animals ; Behavior, Animal ; Cohort Studies ; Depressive Disorder, Major/genetics ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Major/psychology ; Female ; Gene Expression Profiling ; Humans ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/metabolism ; Synapses
Czasopismo naukowe
Tytuł :
Precursor proadrenomedullin influences cardiomyocyte survival and local inflammation related to myocardial infarction.
Autorzy :
Hinrichs S; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Scherschel K; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.; Clinic for Cardiology-Electrophysiology, University Heart Center Hamburg, 20246 Hamburg, Germany.
Krüger S; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Neumann JT; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Schwarzl M; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Yan I; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Warnke S; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.
Ojeda FM; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Zeller T; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Karakas M; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Keller T; Division of Cardiology, Department of Medicine III, Goethe University Frankfurt, 60598 Frankfurt, Germany.; Partner Site Frankfurt, German Center for Cardiovascular Research, 60589 Frankfurt, Germany.
Meyer C; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.; Clinic for Cardiology-Electrophysiology, University Heart Center Hamburg, 20246 Hamburg, Germany.
Blankenberg S; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Westermann D; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Lindner D; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany; .; Partner Site Hamburg/Kiel/Lübeck, German Center for Cardiovascular Research, 20246 Hamburg, Germany.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 11; Vol. 115 (37), pp. E8727-E8736. Date of Electronic Publication: 2018 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenomedullin/*genetics
Inflammation/*genetics
Myocardial Infarction/*genetics
Myocytes, Cardiac/*metabolism
Protein Precursors/*genetics
Adrenomedullin/metabolism ; Adrenomedullin/pharmacology ; Aged ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cells, Cultured ; Cytokines/metabolism ; Female ; Gene Expression/genetics ; Humans ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Male ; Mice, Inbred C57BL ; Middle Aged ; Myocardial Infarction/metabolism ; Myocytes, Cardiac/drug effects ; Protein Precursors/metabolism ; Protein Precursors/pharmacology
Czasopismo naukowe
Tytuł :
Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing.
Autorzy :
Bianco C; Department of Microbiology, NYU School of Medicine, New York, NY 10016.
Thompson L; Department of Microbiology, NYU School of Medicine, New York, NY 10016.
Mohr I; Department of Microbiology, NYU School of Medicine, New York, NY 10016; .; Laura and Isaac Perlmutter Cancer Institute, NYU School of Medicine, New York, NY 10016.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Nov 05; Vol. 116 (45), pp. 22583-22590. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Biosynthesis*
DNA/*metabolism
Elongation Factor 2 Kinase/*genetics
Inflammation/*metabolism
Transcription Factor RelA/*metabolism
Amino Acid Motifs ; DNA/genetics ; Elongation Factor 2 Kinase/chemistry ; Elongation Factor 2 Kinase/metabolism ; Humans ; Inflammation/genetics ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Peptide Elongation Factor 2/genetics ; Peptide Elongation Factor 2/metabolism ; Phosphorylation ; Transcription Factor RelA/genetics
Czasopismo naukowe
Tytuł :
Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice.
Autorzy :
Shen H; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Ji Y; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Xiong Y; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Kim H; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Zhong X; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Jin MG; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Shah YM; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Omary MB; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Liu Y; College of Life Sciences, The Institute for Advanced Studies, Wuhan University, 430072 Wuhan, China.
Qi L; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Rui L; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109; .; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 17; Vol. 116 (38), pp. 19090-19097. Date of Electronic Publication: 2019 Sep 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Autoimmunity/*immunology
I-kappa B Kinase/*physiology
Inflammation/*immunology
Liver/*immunology
Lung/*immunology
Protein-Serine-Threonine Kinases/*physiology
Thymus Gland/*immunology
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/pathology ; Cell Differentiation ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Homeostasis ; Inflammation/metabolism ; Inflammation/pathology ; Liver/metabolism ; Liver/pathology ; Lung/metabolism ; Lung/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NF-kappa B/metabolism ; Thymus Gland/metabolism ; Thymus Gland/pathology
Czasopismo naukowe
Tytuł :
The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids.
Autorzy :
Hua G; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France.
Zein N; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France.
Paulen L; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France.
Chambon P; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France; .; University of Strasbourg Institute for Advanced Study, 67404 Illkirch, France.; Collège de France, 67404 Illkirch, France.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 09; Vol. 116 (28), pp. 14200-14209. Date of Electronic Publication: 2019 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*drug therapy
Osteoporosis/*drug therapy
Receptors, Glucocorticoid/*metabolism
Steroids/*pharmacology
Animals ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Fatty Liver/drug therapy ; Fatty Liver/genetics ; Fatty Liver/pathology ; Glucocorticoids/pharmacology ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Mice ; Osteoporosis/genetics ; Osteoporosis/pathology ; Receptors, Glucocorticoid/agonists ; Receptors, Glucocorticoid/chemistry
Czasopismo naukowe
Tytuł :
Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids.
Autorzy :
Hua G; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France.
Zein N; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France.
Daubeuf F; Laboratoire d'Innovation Thérapeutique, Unité Mixte de Recherche 7200, Faculté de Pharmacie, Centre National de la Recherche Scientifique-Université de Strasbourg, F-67400 Illkirch, France.
Chambon P; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France; .; University of Strasbourg Institute for Advanced Study, 67404 Illkirch, France.; Collège de France, 67404 Illkirch, France.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 09; Vol. 116 (28), pp. 14191-14199. Date of Electronic Publication: 2019 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Glucocorticoids/*pharmacology
Inflammation/*drug therapy
Receptors, Glucocorticoid/*genetics
Animals ; Anti-Inflammatory Agents/chemistry ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/genetics ; Arthritis, Experimental/pathology ; Asthma/drug therapy ; Asthma/genetics ; Asthma/pathology ; Conjunctivitis, Allergic/drug therapy ; Conjunctivitis, Allergic/genetics ; Conjunctivitis, Allergic/pathology ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/pathology ; Dexamethasone/pharmacology ; Disease Models, Animal ; Glucocorticoids/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Mice ; NF-kappa B/genetics ; Ovalbumin/toxicity ; Progestins/chemistry ; Progestins/pharmacology ; Receptors, Glucocorticoid/agonists ; Receptors, Glucocorticoid/chemistry ; Skin/drug effects ; Skin/pathology ; Transcriptional Activation/drug effects
Czasopismo naukowe
Tytuł :
Dynamic secretome of bone marrow-derived stromal cells reveals a cardioprotective biochemical cocktail.
Autorzy :
Kshitiz; Yale Institute of Systems Biology, Yale University, West Haven, CT 06516; .; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT 06030.
Ellison DD; Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21205.
Suhail Y; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT 06030.
Afzal J; Department of Cardiology, University of California, San Francisco, CA 94115.
Woo L; Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21205.
Kilic O; Yale Institute of Systems Biology, Yale University, West Haven, CT 06516.
Spees J; Department of Cellular Molecular and Biomedical Sciences, University of Vermont, Burlington, VT 05405.
Levchenko A; Yale Institute of Systems Biology, Yale University, West Haven, CT 06516; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 09; Vol. 116 (28), pp. 14374-14383. Date of Electronic Publication: 2019 Jun 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mesenchymal Stem Cells*
Inflammation/*genetics
Myocardial Infarction/*genetics
Neovascularization, Physiologic/*genetics
AC133 Antigen/genetics ; Animals ; Bone Marrow/metabolism ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Cell Differentiation/genetics ; Cells, Cultured ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Ligands ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy ; Oxidative Stress/genetics ; Paracrine Communication/genetics
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies