Temat: "Inhibitor of Apoptosis Proteins" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
Autorzy:: Maurya CK; Cytogenetics Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: .
Tapadia MG; Cytogenetics Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: .; Pokaż więcej
Źródło:: Molecular and cellular neurosciences [Mol Cell Neurosci] 2023 Sep; Vol. 126, pp. 103886. Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium*/metabolism
Drosophila*/metabolism
Sarcoplasmic Reticulum Calcium-Transporting ATPases*
Inhibitor of Apoptosis Proteins*
Animals ; Apoptosis ; Calcium-Transporting ATPases ; Endoplasmic Reticulum/metabolism ; Phosphatidylinositol 3-Kinases ; Drosophila Proteins

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Skocz do pozycji: 2.

Tytuł:: The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP.
Autorzy:: Fleischmann J; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Hildebrand LS; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Kuhlmann L; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Fietkau R; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Distel LV; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Jun 17; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents*/pharmacology
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/radiotherapy
Radiation-Sensitizing Agents*/pharmacology
Squamous Cell Carcinoma of Head and Neck*/drug therapy
Squamous Cell Carcinoma of Head and Neck*/radiotherapy
Inhibitor of Apoptosis Proteins*/antagonists & inhibitors
Inhibitor of Apoptosis Proteins*/metabolism
Humans ; Radiation, Ionizing ; X-Linked Inhibitor of Apoptosis Protein/antagonists & inhibitors ; X-Linked Inhibitor of Apoptosis Protein/metabolism

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Skocz do pozycji: 3.

Tytuł:: Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?
Autorzy:: Demirci NS; Department of Medical Oncology, Faculty of Medicine, Istanbul University-Cerrahpasa Cerrahpasa, Turkey.
Çavdar E; Department of Oncology, Faculty of Medicine, Tekirdag Namik Kemal University, Turkey.
Erdem GU; Department of Medical Oncology, Başakşehir Çam and Sakura City Hospital, Turkey.
Hatipoglu E; Department of General Surgery, Faculty of Medicine, Istanbul University-Cerrahpasa Cerrahpasa, Turkey.
Celik E; Department of Medical Oncology, Haydarpaşa Numune Training and Research Hospital, University of Health Sciences, Turkey.
Sezer S; Department of Biochemistry, Ministry of Health Ankara City Hospital, Turkey.
Yolcu A; Department of Radiation Oncology, Tekirdag Namik Kemal University Faculty of Medicine, Turkey.
Dogan M; Department of Medical Oncology, Ankara Oncology Training and Research Hospital, Turkey.
Seber ES; Department of Oncology, Faculty of Medicine, Tekirdag Namik Kemal University, Turkey.; Pokaż więcej
Źródło:: Medicine [Medicine (Baltimore)] 2023 Jun 23; Vol. 102 (25), pp. e34014.
Typ publikacji:: Multicenter Study; Journal Article
MeSH Terms:: Inhibitor of Apoptosis Proteins*
Pancreatic Neoplasms*/pathology
Humans ; Survivin ; Prognosis ; Prospective Studies ; Biomarkers, Tumor

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Skocz do pozycji: 4.

Tytuł:: Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
Autorzy:: Udompholkul P; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
Garza-Granados A; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
Alboreggia G; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
Baggio C; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
McGuire J; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
Pegan SD; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
Pellecchia M; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2023 Jun 22; Vol. 66 (12), pp. 8159-8169. Date of Electronic Publication: 2023 Jun 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms:: Inhibitor of Apoptosis Proteins*
X-Linked Inhibitor of Apoptosis Protein*/metabolism
Protein Binding ; Apoptosis

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Skocz do pozycji: 5.

Tytuł:: A massive machine regulates cell death.
Autorzy:: Mace PD; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Day CL; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1093-1094. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Caspases/metabolism ; Enzyme Activation ; Humans

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Skocz do pozycji: 6.

Tytuł:: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Autorzy:: Ehrmann JF; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna BioCenter, Vienna, Austria.
Grabarczyk DB; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Heinke M; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Deszcz L; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Kurzbauer R; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Hudecz O; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Shulkina A; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna BioCenter, Vienna, Austria.; Max Perutz Labs, University of Vienna, Vienna BioCenter, Vienna, Austria.
Gogova R; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna BioCenter, Vienna, Austria.
Meinhart A; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Versteeg GA; Max Perutz Labs, University of Vienna, Vienna BioCenter, Vienna, Austria.
Clausen T; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1117-1123. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/physiology
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Mitochondrial Proteins*/chemistry
Mitochondrial Proteins*/metabolism
Apoptosis Regulatory Proteins*/chemistry
Apoptosis Regulatory Proteins*/metabolism
Humans ; Autophagy ; Cryoelectron Microscopy ; Ubiquitination

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Skocz do pozycji: 7.

Tytuł:: Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Autorzy:: Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Jin CY; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1105-1111. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Caspases*/chemistry
Caspases*/metabolism
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Mitochondrial Proteins*/chemistry
Mitochondrial Proteins*/metabolism
Apoptosis Regulatory Proteins*/chemistry
Apoptosis Regulatory Proteins*/metabolism
Animals ; Humans ; Cryoelectron Microscopy ; Enzyme Activation ; High-Temperature Requirement A Serine Peptidase 2/chemistry ; High-Temperature Requirement A Serine Peptidase 2/metabolism ; Protein Domains

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Skocz do pozycji: 8.

Tytuł:: Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins.
Autorzy:: Ng YLD; Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany.
Bricelj A; Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, SI-1000 Ljubljana, Slovenia.
Jansen JA; Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany.
Murgai A; Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany.; German Cancer Consortium (DKTK) Partner Site Berlin and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
Peter K; Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany.
Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States.
Gütschow M; Phamaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Krönke J; Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany.; German Cancer Consortium (DKTK) Partner Site Berlin and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
Steinebach C; Phamaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Sosič I; Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, SI-1000 Ljubljana, Slovenia.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2023 Apr 13; Vol. 66 (7), pp. 4703-4733. Date of Electronic Publication: 2023 Mar 30.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Inhibitor of Apoptosis Proteins*/metabolism
Neoplasms*/metabolism
Humans ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin/metabolism ; Ligands

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Skocz do pozycji: 9.

Tytuł:: Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents.
Autorzy:: Wang C; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Cancer Institute, Qingdao University, Qingdao, China.
Zhang Y; The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao University, Qingdao, China.
Shi L; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Cancer Institute, Qingdao University, Qingdao, China.
Yang S; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Cancer Institute, Qingdao University, Qingdao, China.
Chang J; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Cancer Institute, Qingdao University, Qingdao, China.
Zhong Y; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Cancer Institute, Qingdao University, Qingdao, China.
Li Q; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Cancer Institute, Qingdao University, Qingdao, China.
Xing D; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.; Cancer Institute, Qingdao University, Qingdao, China.; School of Life Sciences, Tsinghua University, Beijing, China.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1437-1453.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Inhibitor of Apoptosis Proteins*/metabolism
Proteasome Endopeptidase Complex*/metabolism
Intercellular Signaling Peptides and Proteins ; Ligands ; Proteolysis

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Skocz do pozycji: 10.

Tytuł:: The conservation of IAP-like proteins in fungi, and their potential role in fungal programmed cell death.
Autorzy:: Gebreegziabher Amare M; Department of Plant Pathology, University of Wisconsin - Madison, Madison, WI, USA.
Westrick NM; Department of Plant Pathology, University of Wisconsin - Madison, Madison, WI, USA.
Keller NP; Department of Plant Pathology, University of Wisconsin - Madison, Madison, WI, USA.
Kabbage M; Department of Plant Pathology, University of Wisconsin - Madison, Madison, WI, USA. Electronic address: .; Pokaż więcej
Źródło:: Fungal genetics and biology : FG & B [Fungal Genet Biol] 2022 Sep; Vol. 162, pp. 103730. Date of Electronic Publication: 2022 Aug 23.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*/genetics
Inhibitor of Apoptosis Proteins*/genetics
Inhibitor of Apoptosis Proteins*/metabolism
Animals ; Cell Death ; Fungi/genetics ; Fungi/metabolism ; Host-Pathogen Interactions/genetics

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Skocz do pozycji: 11.

Tytuł:: Downregulation of BIRC2 hinders the progression of rheumatoid arthritis through regulating TRADD.
Autorzy:: Rao Y; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Xu S; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Lu T; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Wang Y; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Liu M; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Zhang W; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.; Pokaż więcej
Źródło:: Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Oct; Vol. 11 (10), pp. e978.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/genetics
Arthritis, Rheumatoid*/genetics
Arthritis, Rheumatoid*/metabolism
Humans ; Down-Regulation ; Lipopolysaccharides/pharmacology ; Signal Transduction ; Inflammation ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism

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Skocz do pozycji: 12.

Tytuł:: Livin promotes Th2-type immune response in airway allergic diseases.
Autorzy:: Wang Y; Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Xiang Z; Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
An M; Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Jia H; Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Bu C; Department of Otolaryngology, Head & Neck Surgery, The First Hospital of Yulin, Yulin, China.
Xue Y; Special Needs Ward, Shanxi Cancer Hospital, Taiyuan, China.
Wei Y; Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Li R; Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Qi X; Department of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.; Key Research Laboratory of Airway Neuroimmunology, Shanxi Province, Taiyuan, China.
Cheng F; Department of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.; Key Research Laboratory of Airway Neuroimmunology, Shanxi Province, Taiyuan, China.
Zhao C; Department of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.; Key Research Laboratory of Airway Neuroimmunology, Shanxi Province, Taiyuan, China.
Xue J; Department of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China. .; Key Research Laboratory of Airway Neuroimmunology, Shanxi Province, Taiyuan, China. .
Yang P; Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China. .; Pokaż więcej
Źródło:: Immunologic research [Immunol Res] 2022 Oct; Vol. 70 (5), pp. 624-632. Date of Electronic Publication: 2022 Jun 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inhibitor of Apoptosis Proteins*/genetics
Inhibitor of Apoptosis Proteins*/immunology
Respiratory Hypersensitivity*/genetics
Respiratory Hypersensitivity*/immunology
Th2 Cells*/immunology
Animals ; Cytokines/immunology ; Disease Models, Animal ; GATA3 Transcription Factor/genetics ; GATA3 Transcription Factor/immunology ; Hypersensitivity ; Immunity ; Interleukin-4/immunology ; Mice ; RNA, Messenger

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Skocz do pozycji: 13.

Tytuł:: A phase I study of LCL161, a novel oral pan-inhibitor of apoptosis protein (IAP) antagonist, in Japanese patients with advanced solid tumors.
Autorzy:: Morita S; Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan.
Minami H; Division of Medical Oncology/Hematology, Department of Internal Medicine, Kobe University Hospital & Graduate School of Medicine, Kobe, Japan.
Mitsuma A; Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan.
Toyoda M; Division of Medical Oncology/Hematology, Department of Internal Medicine, Kobe University Hospital & Graduate School of Medicine, Kobe, Japan.
Kiyota N; Division of Medical Oncology/Hematology, Department of Internal Medicine, Kobe University Hospital & Graduate School of Medicine, Kobe, Japan.
Ando Y; Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan.; Pokaż więcej
Źródło:: Asia-Pacific journal of clinical oncology [Asia Pac J Clin Oncol] 2022 Oct; Vol. 18 (5), pp. e427-e434. Date of Electronic Publication: 2022 Jan 30.
Typ publikacji:: Clinical Trial, Phase I; Journal Article
MeSH Terms:: Inhibitor of Apoptosis Proteins*/administration & dosage
Inhibitor of Apoptosis Proteins*/antagonists & inhibitors
Neoplasms*/drug therapy
Neoplasms*/pathology
Bayes Theorem ; Humans ; Japan ; Paclitaxel ; Thiazoles ; Treatment Outcome

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Skocz do pozycji: 14.

Tytuł:: A new circular RNA-encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)-induced mitochondrial dysfunction.
Autorzy:: Zhao X; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China.
Guo J; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China.
Wang X; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China.
Lin J; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China.
Liu Z; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China.
Xu C; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China.
Zhang D; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China.
Tong D; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P.R. China. Electronic address: .; Pokaż więcej
Źródło:: The Journal of biological chemistry [J Biol Chem] 2022 Sep; Vol. 298 (9), pp. 102280. Date of Electronic Publication: 2022 Jul 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inhibitor of Apoptosis Proteins*/genetics
Inhibitor of Apoptosis Proteins*/metabolism
Mitochondria*/virology
Mitochondrial Permeability Transition Pore*/metabolism
RNA, Circular*/genetics
RNA, Circular*/metabolism
Transmissible gastroenteritis virus*/genetics
Transmissible gastroenteritis virus*/physiology
Animals ; Calcium/metabolism ; Cell Line ; Cyclophilin D/metabolism ; Swine ; Voltage-Dependent Anion Channel 1/metabolism

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Skocz do pozycji: 15.

Tytuł:: Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma.
Autorzy:: Choo Z; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Koh X; Experimental Drug Development Centre, A*STAR, Singapore.
Wong MRE; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.
Ashokan RM; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ali Ahamed NSB; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kang C; Experimental Drug Development Centre, A*STAR, Singapore.
Kuick CH; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.
Chang KTE; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.; Duke NUS Medical School, Singapore.
Larisch S; Cell Death and Cancer Research Laboratory, Department of Human Biology and Medical Sciences, University of Haifa, Haifa, Israel.
Loh AHP; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; Duke NUS Medical School, Singapore.; Cell Death and Cancer Research Laboratory, Department of Human Biology and Medical Sciences, University of Haifa, Haifa, Israel.; Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore.
Chen ZX; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; National University Cancer Institute, Singapore, National University Health System, Singapore.; Pokaż więcej
Źródło:: Cancer research communications [Cancer Res Commun] 2023 Nov 22; Vol. 3 (11), pp. 2386-2399.
Typ publikacji:: Journal Article
MeSH Terms:: X-Linked Inhibitor of Apoptosis Protein*/genetics
Neuroblastoma*/drug therapy
Animals ; Humans ; N-Myc Proto-Oncogene Protein/genetics ; Apoptosis ; Inhibitor of Apoptosis Proteins/metabolism ; Mammals/metabolism

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Skocz do pozycji: 16.

Tytuł:: Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins.
Autorzy:: Li Y; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Lee HH; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jiang VC; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Che Y; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
McIntosh J; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jordan A; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Vargas J; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Zhang T; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yan F; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Simmons ME; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Wang W; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Nie L; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yao Y; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Jain P; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Wang M; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Liu Y; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. .; Pokaż więcej
Źródło:: Cell death & disease [Cell Death Dis] 2023 Nov 02; Vol. 14 (11), pp. 714. Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Lymphoma, Mantle-Cell*/drug therapy
Lymphoma, Mantle-Cell*/metabolism
Humans ; Mice ; Animals ; Adult ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Inhibitor of Apoptosis Proteins/metabolism ; Down-Regulation ; Cell Proliferation ; Cell Line, Tumor ; Apoptosis ; Proto-Oncogene Proteins c-bcl-2/metabolism

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Skocz do pozycji: 17.

Tytuł:: IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition.
Autorzy:: Alicke B; Departments of In Vivo Pharmacology, Genentech, South San Francisco, CA, 94110, USA.
Varfolomeev E; Immunology Discovery, Genentech, South San Francisco, CA, 94110, USA.; Early Discovery Biochemistry, Genentech, South San Francisco, CA, 94110, USA.
Lee SHK; Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, 94110, USA.
Frommlet A; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, 94110, USA.
Ubhayakar S; Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, 94110, USA.
Quinn JG; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, 94110, USA.
Fairbrother WJ; Early Discovery Biochemistry, Genentech, South San Francisco, CA, 94110, USA.
Jones R; Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, 94110, USA.
Gould SE; Departments of In Vivo Pharmacology, Genentech, South San Francisco, CA, 94110, USA.
Vucic D; Immunology Discovery, Genentech, South San Francisco, CA, 94110, USA. .; Early Discovery Biochemistry, Genentech, South San Francisco, CA, 94110, USA. .; Pokaż więcej
Źródło:: Cell death & disease [Cell Death Dis] 2022 Sep 28; Vol. 13 (9), pp. 831. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:: Journal Article
MeSH Terms:: Inhibitor of Apoptosis Proteins*/metabolism
Neoplasms*/drug therapy
Apoptosis ; Cell Death ; Humans

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Szczegóły

Skocz do pozycji: 18.

Tytuł:: XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
Autorzy:: Daoud M; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Broxtermann PN; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Schorn F; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Werthenbach JP; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Seeger JM; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Schiffmann LM; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany.
Brinkmann K; The Walter & Eliza Hall Institute of Medical Research (WEHI) and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.
Vucic D; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.
Tüting T; Laboratory of Experimental Dermatology, Department of Dermatology, University Hospital Magdeburg, Magdeburg, Germany.
Mauch C; Faculty of Medicine and University Hospital of Cologne, Department of Dermatology and Venereology, University of Cologne, Cologne, Germany.
Kulms D; Department of Dermatology, Experimental Dermatology, TU-Dresden, Dresden, Germany.; National Center for Tumor Diseases Dresden, TU-Dresden, Dresden, Germany.
Zigrino P; Faculty of Medicine and University Hospital of Cologne, Department of Dermatology and Venereology, University of Cologne, Cologne, Germany.
Kashkar H; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Pokaż więcej
Źródło:: EMBO reports [EMBO Rep] 2022 Jun 07; Vol. 23 (6), pp. e53608. Date of Electronic Publication: 2022 Apr 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Inhibitor of Apoptosis Proteins*/genetics
Inhibitor of Apoptosis Proteins*/immunology
Melanoma*/genetics
Melanoma*/immunology
Neutrophil Infiltration*/genetics
Neutrophil Infiltration*/immunology
Skin Neoplasms*/genetics
Skin Neoplasms*/immunology
X-Linked Inhibitor of Apoptosis Protein*/genetics
X-Linked Inhibitor of Apoptosis Protein*/immunology
X-Linked Inhibitor of Apoptosis Protein*/metabolism
Adaptor Proteins, Signal Transducing/immunology ; Animals ; Apoptosis/genetics ; Apoptosis/immunology ; Disease Models, Animal ; Humans ; Interleukin-8/biosynthesis ; Mice ; Receptor-Interacting Protein Serine-Threonine Kinase 2/immunology

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Skocz do pozycji: 19.

Tytuł:: Survivin Expression in Luminal Breast Cancer and Adjacent Normal Tissue for Immuno-Oncology Applications.
Autorzy:: Wright S; Saint Mary's Regional Medical Center, Reno, NV 89503, USA.; Western Surgical Group, Reno, NV 89502, USA.
Burkholtz SR; Flow Pharma Inc., Warrensville Heights, OH 44128, USA.
Zelinsky C; Saint Mary's Regional Medical Center, Reno, NV 89503, USA.
Wittman C; Saint Mary's Regional Medical Center, Reno, NV 89503, USA.
Carback RT; Flow Pharma Inc., Warrensville Heights, OH 44128, USA.
Harris PE; Flow Pharma Inc., Warrensville Heights, OH 44128, USA.
Blankenberg T; Flow Pharma Inc., Warrensville Heights, OH 44128, USA.; Shasta Pathology Associates, Redding, CA 96001, USA.
Herst CV; Flow Pharma Inc., Warrensville Heights, OH 44128, USA.
Rubsamen RM; Saint Mary's Regional Medical Center, Reno, NV 89503, USA.; Flow Pharma Inc., Warrensville Heights, OH 44128, USA.; Cleveland Medical Center, University Hospitals, Cleveland, OH 44106, USA.; Case Western Reserve School of Medicine, Cleveland, OH 44106, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 23; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 23.
Typ publikacji:: Journal Article
MeSH Terms:: Breast Neoplasms*/genetics
Breast Neoplasms*/therapy
Breast Neoplasms*/metabolism
Carcinoma, Intraductal, Noninfiltrating*/metabolism
Carcinoma, Ductal, Breast*/pathology
Female ; Humans ; Survivin/genetics ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Breast/metabolism

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Skocz do pozycji: 20.

Tytuł:: Differential regulation of BIRC2 and BIRC3 expression by inflammatory cytokines and glucocorticoids in pulmonary epithelial cells.
Autorzy:: Thorne A; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Bansal A; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Necker-Brown A; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Mostafa MM; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Gao A; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Georgescu A; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Kooi C; Department of Medicine, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Leigh R; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Medicine, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Newton R; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, Lung Health Research Group, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Jun 08; Vol. 18 (6), pp. e0286783. Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Glucocorticoids*/pharmacology
Glucocorticoids*/metabolism
Cytokines*/metabolism
Humans ; Baculoviral IAP Repeat-Containing 3 Protein/genetics ; Baculoviral IAP Repeat-Containing 3 Protein/metabolism ; NF-kappa B/metabolism ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Budesonide/pharmacology ; Tumor Necrosis Factor-alpha/metabolism ; Epithelial Cells/metabolism ; RNA, Messenger/metabolism ; Dexamethasone/pharmacology ; Dexamethasone/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism

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