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Tytuł:
A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A.
Autorzy:
Wang C; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Hu R; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Wang T; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Duan L; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Hou Q; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Wang J; College of Chemistry and Pharmacy, Northwest A&F University, Xianyang, China. Electronic address: .
Yang Z; College of Veterinary Medicine, Northwest A&F University, Xianyang, China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 104605. Date of Electronic Publication: 2023 Mar 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
Carbolines*/chemistry
Carbolines*/pharmacology
Carbolines*/therapeutic use
Herpesvirus 1, Suid*/drug effects
Animals ; Humans ; Mice ; Acyclovir/pharmacology ; Acyclovir/toxicity ; Gene Knockdown Techniques ; Inhibitory Concentration 50 ; Pinocytosis/drug effects ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pseudorabies/drug therapy ; Pseudorabies/prevention & control ; Pseudorabies/virology ; Virus Internalization/drug effects ; HeLa Cells ; Models, Chemical
Czasopismo naukowe
Tytuł:
ارزیابی اثر ضد باکتریایی دي لیمونن نانوانکپسوله شده در نانواسفنج بتاسیکلودکسترین.
Autorzy:
عذرا صالحی
عاطفه رضایی
مسعود سامی
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Alternatywny tytuł:
Evaluation of the antibacterial activity of encapsulated d-limonene inβ-cyclodextrin-based nanosponge.
Źródło:
Journal of Food Science & Technology (2008-8787). Feb2023, Vol. 19 Issue 132, p355-364. 10p.
Tytuł:
Nanopartículas de plata de Borojoa patinoi y su efecto in vitro sobre biopelículas de Candida albicans.
Autorzy:
GOMEZ-GARZÓN, MARCELA
LEÓN ENCISO, JEANNETTE
RAMIREZ, CRISTEL A.
BETANCOURT, CRISTIAN C.
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Alternatywny tytuł:
Silver nanoparticles from Borojoa patinoi and their in vitro effect on Candida albicans biofilms.
Źródło:
Revista EIA. ene2023, Vol. 20 Issue 39, p1-13. 13p.
Tytuł:
Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation.
Autorzy:
Niu B; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Wei S; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Sun J; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Zhao H; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Wang B; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Chen G; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 75-86.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Animals ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Benzylisoquinolines/administration & dosage ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Progression ; Drug Resistance, Neoplasm ; Humans ; Inhibitory Concentration 50 ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Network Pharmacology ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Sorafenib/administration & dosage ; TOR Serine-Threonine Kinases/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes .
Autorzy:
Prommaban A; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Sriyab S; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Marsup P; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.; Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Neimkhum W; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Huachiew Chalermprakiet University, Samutprakarn, Thailand.
Sirithunyalug J; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.
Anuchapreeda S; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
To-Anun C; Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, Chiang Mai, Thailand.
Chaiyana W; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 225-234.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Antioxidants/*pharmacology
Cordyceps/*chemistry
Enzyme Inhibitors/*pharmacology
Monophenol Monooxygenase/*antagonists & inhibitors
Animals ; Antioxidants/administration & dosage ; Antioxidants/isolation & purification ; Ascorbic Acid/pharmacology ; Catechin/analogs & derivatives ; Catechin/pharmacology ; Cattle ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/isolation & purification ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Free Radical Scavengers/administration & dosage ; Free Radical Scavengers/isolation & purification ; Free Radical Scavengers/pharmacology ; Fruiting Bodies, Fungal ; Inhibitory Concentration 50 ; Mycelium ; Skin/drug effects ; Skin/metabolism ; Skin Aging/drug effects ; Swine
SCR Organism:
Cordyceps tenuipes
Czasopismo naukowe
Tytuł:
Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy.
Autorzy:
Shi Z; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Tang J; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Lin C; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Chen T; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Zhang F; Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Huang Y; School of Material Science and Engineering and Institute for Advanced Study, Nanchang University, Nanchang, China.
Luan P; Guangdong Second Provincial General Hospital and Health Science Center, Shenzhen University, Shenzhen, China.
Xin Z; School of Material Science and Engineering and Institute for Advanced Study, Nanchang University, Nanchang, China.
Li Q; Shenzhen Bay Laboratory, Shenzhen, China.
Mei L; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.; Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
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Źródło:
Drug delivery [Drug Deliv] 2022 Dec; Vol. 29 (1), pp. 624-636.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Doxorubicin/*pharmacology
Nanostructures/*chemistry
Neoplasms/*pathology
Photothermal Therapy/*methods
Animals ; Antineoplastic Agents/administration & dosage ; Cell Line, Tumor ; Chemistry, Pharmaceutical ; Dose-Response Relationship, Drug ; Doxorubicin/administration & dosage ; Drug Carriers/chemistry ; Humans ; Hydrogen Peroxide/metabolism ; Inhibitory Concentration 50 ; Iron/chemistry ; Mice ; Phosphorus/chemistry ; Random Allocation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo .
Autorzy:
Bai X; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.; Department of Spine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Jiang M; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Wang J; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Yang S; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.; Department of Spine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Liu Z; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Zhang H; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Zhu X; Department of Geratology, Baoding NO.1 Central Hospital, Baoding, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 427-436.
Typ publikacji:
Journal Article
MeSH Terms:
Anthocyanins/*pharmacology
Apoptosis/*drug effects
Intervertebral Disc Degeneration/*prevention & control
Nucleus Pulposus/*drug effects
Animals ; Anthocyanins/administration & dosage ; Dose-Response Relationship, Drug ; Inhibitory Concentration 50 ; Interleukin-1beta/administration & dosage ; Janus Kinase 2/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Integrating nonlinear analysis and machine learning for human induced pluripotent stem cell-based drug cardiotoxicity testing.
Autorzy:
Kowalczewski A; Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse, New York, USA.; BioInspired Syracuse Institute for Materials and Living Systems, Syracuse University, Syracuse, New York, USA.
Sakolish C; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Hoang P; Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse, New York, USA.; BioInspired Syracuse Institute for Materials and Living Systems, Syracuse University, Syracuse, New York, USA.
Liu X; Department of Mechanical & Aerospace Engineering, Syracuse University, Syracuse, New York, USA.
Jacquir S; Université Paris-Saclay, CNRS, Institut des Neurosciences Paris Saclay, Gif-sur-Yvette, France.
Rusyn I; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Ma Z; Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse, New York, USA.; BioInspired Syracuse Institute for Materials and Living Systems, Syracuse University, Syracuse, New York, USA.
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Źródło:
Journal of tissue engineering and regenerative medicine [J Tissue Eng Regen Med] 2022 Aug; Vol. 16 (8), pp. 732-743. Date of Electronic Publication: 2022 May 27.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
Artificial Intelligence*
Induced Pluripotent Stem Cells*
Machine Learning*
Cardiotoxicity/*diagnosis
Cardiotoxicity/*etiology
Algorithms ; Cardiotoxicity/metabolism ; Humans ; Inhibitory Concentration 50 ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Nonlinear Dynamics ; Pharmaceutical Preparations
Czasopismo naukowe
Tytuł:
Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens.
Autorzy:
Larsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. .
Engqvist H; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Biermann J; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Werner Rönnerman E; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Forssell-Aronsson E; Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Kovács A; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Karlsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Helou K; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Parris TZ; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 02; Vol. 10 (1), pp. 5798. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Neoplasm*
Inhibitory Concentration 50*
Drug Screening Assays, Antitumor/*standards
Antineoplastic Agents/toxicity ; Bortezomib/toxicity ; Carboplatin/toxicity ; Cell Survival ; Cisplatin/toxicity ; Dimethyl Sulfoxide/standards ; Drug Screening Assays, Antitumor/methods ; Humans ; MCF-7 Cells ; Reproducibility of Results
Czasopismo naukowe
Tytuł:
Numerical learning of deep features from drug-exposed cell images to calculate IC50 without staining.
Autorzy:
Cho K; Division of Electronics and Information System Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Techno-Jungangdaero 333, Daegu, 42988, Republic of Korea.
Choi ES; Division of Electronics and Information System Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Techno-Jungangdaero 333, Daegu, 42988, Republic of Korea.
Kim JH; Division of Electronics and Information System Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Techno-Jungangdaero 333, Daegu, 42988, Republic of Korea.
Son JW; Division of Electronics and Information System Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Techno-Jungangdaero 333, Daegu, 42988, Republic of Korea. .
Kim E; Division of Electronics and Information System Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Techno-Jungangdaero 333, Daegu, 42988, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 22; Vol. 12 (1), pp. 6610. Date of Electronic Publication: 2022 Apr 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Algorithms*
Neural Networks, Computer*
Doxorubicin/pharmacology ; HEK293 Cells ; Humans ; Image Processing, Computer-Assisted/methods ; Inhibitory Concentration 50 ; Staining and Labeling
Czasopismo naukowe
Tytuł:
Anti-malarial activity in a Chinese herbal supplement containing Inonotus obliquus and Panax notoginseng.
Autorzy:
Endo T; Laboratory of Veterinary Infectious Diseases, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Nakagomi Y; Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Kawaguchi E; Laboratory of Veterinary Infectious Diseases, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Hayakawa ESH; Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Yakushiji 3311-1, Shimotsuke, Tochigi 329-0498, Japan.
Vu HN; Department of Parasitology, Faculty of Veterinary Medicine, Viet Nam National University of Agriculture, Viet Nam.
Takemae H; Center for Infectious Disease Epidemiology and Prevention Research, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Shinohara Y; Iskra Industry Co., Ltd., Japan.
Yang D; Iskra Industry Co., Ltd., Japan.
Usui T; Laboratory of Veterinary Pharmacology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Mizutani T; Center for Infectious Disease Epidemiology and Prevention Research, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Nakao Y; Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Furuya T; Laboratory of Veterinary Infectious Diseases, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan. Electronic address: .
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Źródło:
Parasitology international [Parasitol Int] 2022 Apr; Vol. 87, pp. 102532. Date of Electronic Publication: 2021 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
Antimalarials/*therapeutic use
Drugs, Chinese Herbal/*therapeutic use
Inonotus/*chemistry
Malaria, Falciparum/*drug therapy
Panax notoginseng/*chemistry
Plasmodium falciparum/*drug effects
Antimalarials/pharmacology ; Antimalarials/toxicity ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; Drug Resistance ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; Japan
SCR Organism:
Inonotus obliquus
Czasopismo naukowe
Tytuł:
The role of Acanthamoeba castellanii (T4 genotype) antioxidant enzymes in parasite survival under H 2 O 2 -induced oxidative stress.
Autorzy:
Motavallihaghi S; Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Khodadadi I; Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: .
Goudarzi F; Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Afshar S; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Shahbazi AE; School of Nursing and Midwifery, Saveh University of Medical Sciences, Saveh, Iran.
Maghsood AH; Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: .
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Źródło:
Parasitology international [Parasitol Int] 2022 Apr; Vol. 87, pp. 102523. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji:
Journal Article
MeSH Terms:
Acanthamoeba castellanii/*enzymology
Antioxidants/*physiology
Hydrogen Peroxide/*adverse effects
Oxidative Stress/*physiology
Acanthamoeba castellanii/classification ; Acanthamoeba castellanii/genetics ; Acanthamoeba castellanii/metabolism ; Animals ; Antioxidants/metabolism ; Apoptosis ; Catalase/metabolism ; Cell Cycle ; Gene Expression Regulation, Enzymologic ; Genotype ; Glutathione Peroxidase/genetics ; Glutathione Peroxidase/metabolism ; Glutathione Reductase/genetics ; Glutathione Reductase/metabolism ; Inhibitory Concentration 50 ; Oxidative Stress/drug effects ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł:
High polarity extracts obtained from Ilex guayusa Loes. leaves, exhibit antioxidant capacity.
Autorzy:
Cárdenas Tavera, Camila Florenza
Castañeda Villate, Jenny Carolina
Hernández Roa, Mayerly Johanna
Rodríguez Aguirre, Oscar Eduardo
Borrego-Muñoz, Paola
Pombo Ospina, Luis Miguel
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Alternatywny tytuł:
Extractos de alta polaridad obtenidos a partir de las hojas de Ilex guayusa Loes. exhiben capacidad antioxidante.
Źródło:
Vitae (01214004). 2022, Vol. 29 Issue 1, p1-10. 10p.
Tytuł:
Inhibitory effects of phenolic glycosides from Trollius chinensis Bunge on α-glucosidase: inhibition kinetics and mechanisms.
Autorzy:
Feng J; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
He F; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
Huang Y; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
Zhou M; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
Liu X; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
Ye X; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
Yang R; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
Tian W; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
Chen H; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, People's Republic of China. .
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Źródło:
Food & function [Food Funct] 2022 Mar 07; Vol. 13 (5), pp. 2857-2864. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Ranunculaceae*
Glycoside Hydrolase Inhibitors/*pharmacology
Glycosides/*pharmacology
Phenols/*pharmacology
Plant Extracts/*pharmacology
alpha-Glucosidases/*drug effects
Flowers ; Glycoside Hydrolase Inhibitors/chemistry ; Glycosides/chemistry ; Glycosides/pharmacokinetics ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Phenols/chemistry ; Phenols/pharmacokinetics ; Plant Extracts/chemistry ; Plant Extracts/pharmacokinetics ; alpha-Glucosidases/chemistry
Czasopismo naukowe
Tytuł:
Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS.
Autorzy:
Jia W; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences, Qinghai 810008, China. .; University of Chinese Academy of Sciences, Beijing, China.
Bi Q; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences, Qinghai 810008, China. .; University of Chinese Academy of Sciences, Beijing, China.
Jiang S; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences, Qinghai 810008, China. .; University of Chinese Academy of Sciences, Beijing, China.
Tao J; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences, Qinghai 810008, China. .
Liu L; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences, Qinghai 810008, China. .
Yue H; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences, Qinghai 810008, China. .
Zhao X; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences, Qinghai 810008, China. .
Pokaż więcej
Źródło:
Food & function [Food Funct] 2022 Mar 07; Vol. 13 (5), pp. 2456-2464. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Codonopsis*
Diabetes Mellitus, Experimental/*prevention & control
Drugs, Chinese Herbal/*pharmacology
Hypoglycemic Agents/*pharmacology
Plant Extracts/*pharmacology
Alloxan ; Animals ; Animals, Outbred Strains ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/chemistry ; Glucosidases/drug effects ; Hypoglycemic Agents/chemistry ; Inhibitory Concentration 50 ; Male ; Mice ; Phytotherapy ; Plant Extracts/chemistry ; Plant Roots
SCR Organism:
Kunming mice
Czasopismo naukowe

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