Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Inhibitory Concentration 50"" wg kryterium: Temat


Tytuł :
Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens.
Autorzy :
Larsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. .
Engqvist H; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Biermann J; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Werner Rönnerman E; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Forssell-Aronsson E; Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Kovács A; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Karlsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Helou K; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Parris TZ; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Apr 02; Vol. 10 (1), pp. 5798. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Inhibitory Concentration 50*
Drug Screening Assays, Antitumor/*standards
Antineoplastic Agents/toxicity ; Bortezomib/toxicity ; Carboplatin/toxicity ; Cell Survival ; Cisplatin/toxicity ; Dimethyl Sulfoxide/standards ; Drug Screening Assays, Antitumor/methods ; Humans ; MCF-7 Cells ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Assessing the in vitro sensitivity with associated drug resistance polymorphisms in Plasmodium vivax clinical isolates from Delhi, India.
Autorzy :
Matlani M; Department of Microbiology,Vardhman Mahavir Medical College and Safdarjung Hospital, Delhi, India.
Kumar A; Cell Biology Laboratory and Malaria Parasite Bank, ICMR-National Institute of Malaria Research, New Delhi, India.
Singh V; Cell Biology Laboratory and Malaria Parasite Bank, ICMR-National Institute of Malaria Research, New Delhi, India. Electronic address: .
Pokaż więcej
Źródło :
Experimental parasitology [Exp Parasitol] 2021 Jan; Vol. 220, pp. 108047. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Genetic*
Antimalarials/*pharmacology
Drug Resistance/*genetics
Malaria, Vivax/*parasitology
Plasmodium vivax/*drug effects
Adolescent ; Adult ; Aged ; Antimalarials/therapeutic use ; Base Sequence ; Child ; Child, Preschool ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; DNA, Protozoan ; Dose-Response Relationship, Drug ; Female ; Genotype ; Haplotypes ; Humans ; India/epidemiology ; Inhibitory Concentration 50 ; Malaria, Vivax/drug therapy ; Malaria, Vivax/epidemiology ; Male ; Middle Aged ; Plasmodium vivax/classification ; Plasmodium vivax/genetics ; Polymerase Chain Reaction ; Sequence Alignment ; Species Specificity ; Young Adult
Czasopismo naukowe
Tytuł :
Cystoisospora suis merozoite development assay for screening of drug efficacy in vitro.
Autorzy :
Joachim A; Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Austria. Electronic address: .
Ruttkowski B; Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Austria.
Pokaż więcej
Źródło :
Experimental parasitology [Exp Parasitol] 2021 Jan; Vol. 220, pp. 108035. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Coccidiosis/*veterinary
Coccidiostats/*pharmacology
Sarcocystidae/*drug effects
Swine Diseases/*parasitology
Triazines/*pharmacology
Animals ; Cell Line ; Coccidiosis/drug therapy ; Coccidiosis/parasitology ; Coccidiostats/metabolism ; Coccidiostats/therapeutic use ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/veterinary ; Drug Resistance ; Inhibitory Concentration 50 ; Merozoites/drug effects ; Merozoites/growth & development ; Pilot Projects ; Piperidines/pharmacology ; Pyrimidines/pharmacology ; Quinolines/pharmacology ; Real-Time Polymerase Chain Reaction ; Sarcocystidae/growth & development ; Sulfones/chemistry ; Sulfoxides/chemistry ; Swine ; Swine Diseases/drug therapy ; Triazines/metabolism ; Triazines/therapeutic use
Czasopismo naukowe
Tytuł :
Effects of rapamycin and AZD3463 combination on apoptosis, autophagy, and cell cycle for resistance control in breast cancer.
Autorzy :
Ozates NP; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Soğutlu F; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Lerminoglu F; Department of Toxicology, Ege University Pharmacy Faculty, Izmir, Turkey.
Demir B; Department of Toxicology, Ege University Pharmacy Faculty, Izmir, Turkey.
Gunduz C; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Shademan B; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Avci CB; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118643. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Apoptosis/*drug effects
Autophagy/*drug effects
Breast Neoplasms/*pathology
Cell Cycle/*drug effects
Sirolimus/*pharmacology
Autophagosomes/drug effects ; Autophagosomes/metabolism ; Breast Neoplasms/genetics ; Cell Survival/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Glycolysis/drug effects ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Oxygen Consumption/drug effects ; Phenotype
Czasopismo naukowe
Tytuł :
Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor.
Autorzy :
Georgakis N; Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
Ioannou E; Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
Varotsou C; Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
Premetis G; Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
Chronopoulou EG; Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
Labrou NE; Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece. .
Pokaż więcej
Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2089, pp. 41-46.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inhibitory Concentration 50*
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Kinetics ; Molecular Docking Simulation ; Pharmaceutical Preparations/chemistry
Czasopismo naukowe
Tytuł :
Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro .
Autorzy :
Curreli F; Laboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
Victor SMB; Laboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
Ahmed S; Laboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
Drelich A; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.
Tong X; CPS Scientific, Inc., San Jose, California, USA.
Tseng CK; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.; Center of Biodefense and Emerging Disease, The University of Texas Medical Branch, Galveston, Texas, USA.
Hillyer CD; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
Debnath AK; Laboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA .
Pokaż więcej
Źródło :
MBio [mBio] 2020 Dec 11; Vol. 11 (6). Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*chemistry
Peptides/*pharmacology
SARS-CoV-2/*drug effects
SARS-CoV-2/*physiology
Virus Attachment/*drug effects
A549 Cells ; Animals ; Binding Sites ; Chlorocebus aethiops ; Humans ; Inhibitory Concentration 50 ; Peptides/chemical synthesis ; Protein Binding ; Vero Cells
Czasopismo naukowe
Tytuł :
Methyl lucidone induces apoptosis and G 2 /M phase arrest via the PI3K/Akt/NF-κB pathway in ovarian cancer cells.
Autorzy :
Yoon JH; Department of Bioscience and Biotechnology, Research Institute of Bioactive-Metabolome Network, Konkuk University, Seoul, Republic of Korea.
Shin JW; Department of Bioscience and Biotechnology, Research Institute of Bioactive-Metabolome Network, Konkuk University, Seoul, Republic of Korea.
Pham TH; Department of Bioscience and Biotechnology, Research Institute of Bioactive-Metabolome Network, Konkuk University, Seoul, Republic of Korea.
Choi YJ; Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ryu HW; Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheungbuk-do, Republic of Korea.
Oh SR; Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheungbuk-do, Republic of Korea.
Oh JW; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, Republic of Korea.
Yoon DY; Department of Bioscience and Biotechnology, Research Institute of Bioactive-Metabolome Network, Konkuk University, Seoul, Republic of Korea.
Pokaż więcej
Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 51-59.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Cyclopentanes/*pharmacology
Ovarian Neoplasms/*drug therapy
Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclopentanes/administration & dosage ; Cyclopentanes/isolation & purification ; Female ; Fruit ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Inhibitory Concentration 50 ; Lindera/chemistry ; M Phase Cell Cycle Checkpoints/drug effects ; NF-kappa B/metabolism ; Ovarian Neoplasms/pathology ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives.
Autorzy :
Šagud I; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Maček Hrvat N; Institute for Medical Research and Occupational Health, Biochemistry and Analytic Organic Chemistry Unit, Zagreb, Croatia.
Grgičević A; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Čadež T; Institute for Medical Research and Occupational Health, Biochemistry and Analytic Organic Chemistry Unit, Zagreb, Croatia.
Hodak J; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Dragojević M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Lasić K; TEVA, Pliva Tapi R&D, Zagreb, Croatia.
Kovarik Z; Institute for Medical Research and Occupational Health, Biochemistry and Analytic Organic Chemistry Unit, Zagreb, Croatia.
Škorić I; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Pokaż więcej
Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 460-467.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Benzylamines/*chemistry
Cholinesterase Inhibitors/*chemistry
Cholinesterase Inhibitors/*pharmacology
Oxazoles/*chemistry
Acetylcholinesterase/drug effects ; Butyrylcholinesterase/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Electrochemical Techniques ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Photochemical Processes ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Nanotechnology enabled the enhancement of antitrypanosomal activity of piperine against Trypanosoma evansi.
Autorzy :
Rani R; ICAR-National Research Centre on Equine, Hisar, 125001, Haryana, India.
Kumar S; Department of Bio and Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar, 125001, India.
Dilbaghi N; Department of Bio and Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar, 125001, India.
Kumar R; ICAR-National Research Centre on Equine, Hisar, 125001, Haryana, India. Electronic address: .
Pokaż więcej
Źródło :
Experimental parasitology [Exp Parasitol] 2020 Dec; Vol. 219, pp. 108018. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Benzodioxoles/*pharmacology
Cytochrome P-450 Enzyme Inhibitors/*pharmacology
Piperidines/*pharmacology
Polyunsaturated Alkamides/*pharmacology
Trypanosoma/*drug effects
Alkaloids/toxicity ; Analysis of Variance ; Animals ; Benzodioxoles/toxicity ; Cytochrome P-450 Enzyme Inhibitors/toxicity ; Horses ; Inhibitory Concentration 50 ; Leukocytes, Mononuclear/drug effects ; Nanocapsules ; Piperidines/toxicity ; Polyunsaturated Alkamides/toxicity ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/metabolism ; Trypanosoma/growth & development
Czasopismo naukowe
Tytuł :
Developing protein arginine methyltransferase 1 (PRMT1) inhibitor TC-E-5003 as an antitumor drug using INEI drug delivery systems.
Autorzy :
Zhang P; College of Life Sciences, Zhejiang University, Hangzhou, China.
Tao H; Institute of Hygiene, Zhejiang Academy of Medical Science, China.
Yu L; College of Life Sciences, Zhejiang University, Hangzhou, China.
Zhou L; College of Life Sciences, Zhejiang University, Hangzhou, China.
Zhu C; College of Life Sciences, Zhejiang University, Hangzhou, China.
Pokaż więcej
Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 491-501.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Delivery Systems*
Antineoplastic Agents/*administration & dosage
Lung Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Enbucrilate/chemistry ; Female ; Humans ; Inhibitory Concentration 50 ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Inbred ICR ; Mice, Nude ; Oleic Acids/chemistry ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Repressor Proteins/antagonists & inhibitors ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes.
Autorzy :
Zhang X; Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, PR China.
Feng P; Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, PR China.
Gao X; Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, PR China.
Wang B; Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, PR China.
Gou C; Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, PR China.
Bian R; Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, PR China.
Pokaż więcej
Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 247-252.
Typ publikacji :
Journal Article
MeSH Terms :
Benzylisoquinolines/*pharmacology
Cytochrome P-450 Enzyme Inhibitors/*pharmacology
Cytochrome P-450 Enzyme System/*metabolism
Liver/*drug effects
Microsomes, Liver/*drug effects
Stephania/*chemistry
Benzylisoquinolines/isolation & purification ; Cytochrome P-450 Enzyme Inhibitors/isolation & purification ; Humans ; In Vitro Techniques ; Inhibitory Concentration 50 ; Liver/enzymology ; Microsomes, Liver/enzymology ; Molecular Structure ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł :
Astragaloside IV protects ATDC5 cells from lipopolysaccharide-caused damage through regulating miR-203/MyD88.
Autorzy :
Li D; Department of Sports Medicine, Jilin City Central Hospital, Jilin, China.
Li G; Department of Joint Surgery, Jilin City Central Hospital, Jilin, China.
Chen Y; Department of Dermatology, Jilin City Central Hospital, Jilin, China.
Li Y; Department of Joint Surgery, Jilin City Central Hospital, Jilin, China.
Zhang J; Department of Joint Surgery, Jilin City Central Hospital, Jilin, China.
Gao D; Department of Joint Surgery, Jilin City Central Hospital, Jilin, China.
Sun L; Department of Sports Medicine, Jilin City Central Hospital, Jilin, China.
Liu B; Department of Joint Surgery, Jilin City Central Hospital, Jilin, China.
Pokaż więcej
Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 89-97.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Inflammation/*drug therapy
Saponins/*pharmacology
Triterpenes/*pharmacology
Animals ; Anti-Inflammatory Agents/administration & dosage ; Cell Line ; Gene Knockdown Techniques ; Inflammation/pathology ; Inhibitory Concentration 50 ; Lipopolysaccharides ; Mice ; MicroRNAs/genetics ; Myeloid Differentiation Factor 88/genetics ; NF-kappa B/metabolism ; Osteoarthritis/drug therapy ; Saponins/administration & dosage ; Signal Transduction/drug effects ; Triterpenes/administration & dosage
Czasopismo naukowe
Tytuł :
Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19.
Autorzy :
Liu P; Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Cai J; Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Jia R; Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Xia S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
Wang X; Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Cao L; Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Zeng M; Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Xu J; Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Pokaż więcej
Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 1254-1258.
Typ publikacji :
Letter
MeSH Terms :
Virus Shedding*
Antibodies, Neutralizing/*biosynthesis
Betacoronavirus/*immunology
Betacoronavirus/*isolation & purification
Coronavirus Infections/*virology
Pneumonia, Viral/*virology
Antibodies, Neutralizing/blood ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/immunology ; Feces/virology ; Female ; Humans ; Infant ; Inhibitory Concentration 50 ; Male ; Nasopharynx/virology ; Oropharynx/virology ; Pandemics ; Pneumonia, Viral/immunology ; RNA, Viral/analysis ; SARS-CoV-2 ; Time Factors
Opinia redakcyjna
Tytuł :
Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress.
Autorzy :
Alkhatib MH; Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Alyamani SA; Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Abdu F; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Pokaż więcej
Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 422-430.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Nanoparticles*
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Methotrexate/*administration & dosage
A549 Cells ; Animals ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/toxicity ; Carcinoma, Ehrlich Tumor/drug therapy ; Coconut Oil/chemistry ; Emulsions ; Humans ; Inhibitory Concentration 50 ; Methotrexate/pharmacology ; Methotrexate/toxicity ; Mice ; Oxidative Stress/drug effects ; Particle Size
Czasopismo naukowe
Tytuł :
Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes.
Autorzy :
He SD; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Huang SG; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Zhu HJ; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Luo XG; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Liao KH; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Zhang JY; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Tan N; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Li DY; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Pokaż więcej
Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 146-151.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Arthritis, Rheumatoid/*drug therapy
Diterpenes, Kaurane/*pharmacology
Fibroblasts/*drug effects
Synoviocytes/*drug effects
Apoptosis/drug effects ; Autophagy/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Chloroquine/administration & dosage ; Chloroquine/pharmacology ; Diterpenes, Kaurane/administration & dosage ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Fibroblasts/cytology ; Humans ; Inhibitory Concentration 50 ; Synoviocytes/cytology ; Time Factors
Czasopismo naukowe
Tytuł :
Assessment of in vitro and in vivo antimalarial efficacy and GC-fingerprints of selected medicinal plant extracts.
Autorzy :
Sachdeva C; Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Sector-125, Noida, 201313, Uttar Pradesh, India.
Mohanakrishnan D; National Institute of Pharmaceutical Education and Research, Guwahati, 781125, Assam, India.
Kumar S; Germplasm Division, National Bureau of Plant Genetic Resources, Indian Council of Agricultural Research, Ministry of Agriculture (Govt. of India), New Delhi, 110012, India.
Kaushik NK; Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Sector-125, Noida, 201313, Uttar Pradesh, India. Electronic address: .
Pokaż więcej
Źródło :
Experimental parasitology [Exp Parasitol] 2020 Dec; Vol. 219, pp. 108011. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials/*pharmacology
Plant Extracts/*pharmacology
Plants, Medicinal/*chemistry
Plasmodium berghei/*drug effects
Plasmodium falciparum/*drug effects
Acacia/chemistry ; Animals ; Antimalarials/classification ; Antimalarials/toxicity ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Ethnopharmacology ; Female ; Gas Chromatography-Mass Spectrometry ; HEK293 Cells ; Humans ; India ; Inhibitory Concentration 50 ; Medicine, East Asian Traditional ; Mice ; Mice, Inbred BALB C ; Plant Extracts/toxicity ; Plant Leaves/chemistry ; Plants, Medicinal/classification ; Rubus/chemistry ; Syzygium/chemistry
Czasopismo naukowe
Tytuł :
Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents.
Autorzy :
Zhao F; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, PR China.; College of Forestry, Nanjing Forestry University, Nanjing, PR China.; College of Science, Nanjing Forestry University, Nanjing, PR China.
Sun X; College of Science, Nanjing Forestry University, Nanjing, PR China.; College of Information Science and Technology, Nanjing Forestry University, Nanjing, PR China.
Lu W; College of Science, Nanjing Forestry University, Nanjing, PR China.
Xu L; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, PR China.; College of Science, Nanjing Forestry University, Nanjing, PR China.
Shi J; College of Science, Nanjing Forestry University, Nanjing, PR China.
Yang S; Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing, PR China.
Zhou M; Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing, PR China.
Su F; Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing, PR China.
Lin F; Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing, PR China.
Cao F; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, PR China.; College of Forestry, Nanjing Forestry University, Nanjing, PR China.
Pokaż więcej
Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 216-227.
Typ publikacji :
Journal Article
MeSH Terms :
Abietanes/*chemistry
Abietanes/*pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Cell Line, Tumor ; Cell Survival ; Dose-Response Relationship, Drug ; Doxycycline/pharmacology ; Humans ; Inhibitory Concentration 50 ; Molecular Structure
Czasopismo naukowe
Tytuł :
Combinatorial Cytotoxic Effects of 2,3-Dichloro-5,8-dimethoxy-1,4-naphthoquinone and 4-hydroxytamoxifen in Triple-negative Breast Cancer Cell Lines.
Autorzy :
Robinson AGJ; Department of Pharmacology, College of Medicine, Howard University, Washington, DC, U.S.A.
Kanaan YM; Department of Microbiology, College of Medicine, Howard University, Washington, DC, U.S.A.; Cancer Center, Howard University, Washington, DC, U.S.A.
Copeland RL; Department of Pharmacology, College of Medicine, Howard University, Washington, DC, U.S.A. .; Cancer Center, Howard University, Washington, DC, U.S.A. .
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6623-6635. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Naphthoquinones/*pharmacology
Tamoxifen/*analogs & derivatives
Triple Negative Breast Neoplasms/*pathology
Cell Line, Tumor ; Cell Survival/drug effects ; Drug Synergism ; Female ; Humans ; Inhibitory Concentration 50 ; Reactive Oxygen Species/metabolism ; Tamoxifen/pharmacology
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies