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Tytuł:
Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies.
Autorzy:
Al-Karmalawy, Ahmed A. (AUTHOR)
El-Gamil, Dalia S. (AUTHOR)
El-Shesheny, Rabeh (AUTHOR)
Sharaky, Marwa (AUTHOR)
Alnajjar, Radwan (AUTHOR)
Kutkat, Omnia (AUTHOR)
Moatasim, Yassmin (AUTHOR)
Elagawany, Mohamed (AUTHOR)
Al-Rashood, Sara T. (AUTHOR)
Binjubair, Faizah A. (AUTHOR)
Eldehna, Wagdy M. (AUTHOR)
Noreddin, Ayman M. (AUTHOR)
Zakaria, Mohamed Y. (AUTHOR)
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Źródło:
Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-19. 19p.
Czasopismo naukowe
Tytuł:
m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway.
Autorzy:
Lin, Kai (AUTHOR)
Zhou, Endi (AUTHOR)
Shi, Ting (AUTHOR)
Zhang, Siqing (AUTHOR)
Zhang, Jinfan (AUTHOR)
Zheng, Ziruo (AUTHOR)
Pan, Yuetian (AUTHOR)
Gao, Wentao (AUTHOR)
Yu, Yabin (AUTHOR)
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Źródło:
Journal of Experimental & Clinical Cancer Research (17569966). 11/21/2023, Vol. 42 Issue 1, p1-19. 19p.
Czasopismo naukowe
Tytuł:
Inhibitory effects on bovine babesial infection by iron chelator, 1-(N-acetyl-6-aminohexyl)- 3-hydroxy-2-methylpyridin-4-one (CM1), and antimalarial drugs.
Autorzy:
Koonyosying P; Laboratory of Veterinary Vaccine and Biological Products, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand; Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Srichairatanakool S; Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Tiwananthagorn S; Laboratory of Veterinary Vaccine and Biological Products, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand.
Sthitmatee N; Laboratory of Veterinary Vaccine and Biological Products, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand. Electronic address: .
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Źródło:
Veterinary parasitology [Vet Parasitol] 2023 Dec; Vol. 324, pp. 110055. Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Antimalarials*/pharmacology
Antimalarials*/therapeutic use
Babesiosis*/drug therapy
Babesiosis*/parasitology
Babesia*
Cattle Diseases*/drug therapy
Animals ; Cattle ; Humans ; Pyrimethamine/pharmacology ; Primaquine/pharmacology ; Primaquine/therapeutic use ; Iron Chelating Agents/pharmacology ; Iron Chelating Agents/therapeutic use ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Inhibitory Concentration 50 ; Mammals
Czasopismo naukowe
Tytuł:
Anti-Biofilm: Machine Learning Assisted Prediction of IC 50 Activity of Chemicals Against Biofilms of Microbes Causing Antimicrobial Resistance and Implications in Drug Repurposing.
Autorzy:
Rajput A; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India.
Bhamare KT; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Thakur A; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Kumar M; Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Jul 15; Vol. 435 (14), pp. 168115. Date of Electronic Publication: 2023 Apr 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Bacterial Agents*/pharmacology
Anti-Bacterial Agents*/chemistry
Biofilms*/drug effects
Drug Repositioning*
Drug Resistance, Bacterial*
Machine Learning*
Humans ; Microbial Sensitivity Tests ; Inhibitory Concentration 50
Czasopismo naukowe
Tytuł:
New antiprotozoal sesquiterpene derivatives from Dorema glabrum Fisch & C.A.Mey.
Autorzy:
Delnavazi MR; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
Ebrahimi SN; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C, Evin, Tehran, Iran.
Hadjiakhoondi A; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Yassa N; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło:
Fitoterapia [Fitoterapia] 2023 Jul; Vol. 168, pp. 105517. Date of Electronic Publication: 2023 Apr 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antiprotozoal Agents*/pharmacology
Sesquiterpenes*/pharmacology
Sesquiterpenes*/chemistry
Ferula*
Leishmania donovani*
Trypanosoma cruzi*
Animals ; Rats ; Molecular Structure ; Magnetic Resonance Spectroscopy ; Plasmodium falciparum ; Trypanosoma brucei rhodesiense ; Inhibitory Concentration 50 ; Parasitic Sensitivity Tests
Czasopismo naukowe
Tytuł:
Photodynamic therapy of lung cancer with photosensitizers based on polycationic derivatives of synthetic bacteriochlorin (experimental study).
Autorzy:
Kogan EA; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia.
Meerovich GA; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia; National Research Nuclear University 'MEPhI', Moscow 115409, Russia.
Karshieva SS; N.N. Blokhin National Medical Research Center of Oncology, Moscow 115478, Russia; National University of Science and Technology MISIS, Moscow 119049, Russia.
Makarova EA; Organic Intermediates and Dyes Institute, Moscow 123001, Russia.
Romanishkin ID; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia. Electronic address: .
Akhlyustina EV; National Research Nuclear University 'MEPhI', Moscow 115409, Russia.
Meerovich IG; Research Center of Biotechnology of the Russian Academy of Sciences, A.N. Bach Institute of Biochemistry, Moscow 119071, Russia.
Zharkov NV; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia.
Koudan EV; National University of Science and Technology MISIS, Moscow 119049, Russia.
Demura TA; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia.
Loschenov VB; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia; National Research Nuclear University 'MEPhI', Moscow 115409, Russia.
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Źródło:
Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2023 Jun; Vol. 42, pp. 103647. Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Photochemotherapy*/standards
Lung Neoplasms*/therapy
Porphyrins*/chemical synthesis
Porphyrins*/pharmacology
Porphyrins*/therapeutic use
Carcinoma, Lewis Lung*/therapy
Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Inhibitory Concentration 50 ; Survival Analysis ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Animals ; Mice ; Neovascularization, Physiologic/drug effects ; Cell Survival/drug effects
Czasopismo naukowe
Tytuł:
A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A.
Autorzy:
Wang C; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Hu R; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Wang T; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Duan L; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Hou Q; College of Veterinary Medicine, Northwest A&F University, Xianyang, China.
Wang J; College of Chemistry and Pharmacy, Northwest A&F University, Xianyang, China. Electronic address: .
Yang Z; College of Veterinary Medicine, Northwest A&F University, Xianyang, China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 104605. Date of Electronic Publication: 2023 Mar 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
Carbolines*/chemistry
Carbolines*/pharmacology
Carbolines*/therapeutic use
Herpesvirus 1, Suid*/drug effects
Animals ; Humans ; Mice ; Acyclovir/pharmacology ; Acyclovir/toxicity ; Gene Knockdown Techniques ; Inhibitory Concentration 50 ; Pinocytosis/drug effects ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pseudorabies/drug therapy ; Pseudorabies/prevention & control ; Pseudorabies/virology ; Virus Internalization/drug effects ; HeLa Cells ; Models, Chemical ; Dyrk Kinases
Czasopismo naukowe
Tytuł:
ارزیابی اثر ضد باکتریایی دي لیمونن نانوانکپسوله شده در نانواسفنج بتاسیکلودکسترین.
Autorzy:
عذرا صالحی
عاطفه رضایی
مسعود سامی
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Alternatywny tytuł:
Evaluation of the antibacterial activity of encapsulated d-limonene inβ-cyclodextrin-based nanosponge.
Źródło:
Journal of Food Science & Technology (2008-8787). Feb2023, Vol. 19 Issue 132, p355-364. 10p.
Czasopismo naukowe
Tytuł:
Nanopartículas de plata de Borojoa patinoi y su efecto in vitro sobre biopelículas de Candida albicans.
Autorzy:
GOMEZ-GARZÓN, MARCELA
LEÓN ENCISO, JEANNETTE
RAMIREZ, CRISTEL A.
BETANCOURT, CRISTIAN C.
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Alternatywny tytuł:
Silver nanoparticles from Borojoa patinoi and their in vitro effect on Candida albicans biofilms.
Źródło:
Revista EIA. ene2023, Vol. 20 Issue 39, p1-13. 13p.
Czasopismo naukowe
Tytuł:
DFT based Computational Methodology of IC 50 Prediction.
Autorzy:
Bag A; Department of Applied Science Under School of Natural & Applied Sciences, Maulana Abul Kalam Azad University of Technology, West Bengal, Simhat, Haringhata, Nadia 741249, India.
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Źródło:
Current computer-aided drug design [Curr Comput Aided Drug Des] 2021; Vol. 17 (2), pp. 244-253.
Typ publikacji:
Journal Article
MeSH Terms:
Computer Simulation*
Inhibitory Concentration 50*
Quantitative Structure-Activity Relationship*
Anti-HIV Agents/*chemistry
Antineoplastic Agents/*chemistry
Drug Design/*methods
Anti-HIV Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Capsid Proteins/antagonists & inhibitors ; Capsid Proteins/physiology ; Forecasting ; HIV-1/drug effects ; HIV-1/physiology ; Humans
Czasopismo naukowe
Tytuł:
In vitro neuraminidase inhibitory concentrations (IC50) of four neuraminidase inhibitors in the Japanese 2022–23 season: Comparison with the 2010–11 to 2019–20 seasons.
Autorzy:
Goto, Takeyuki (AUTHOR)
Kawai, Naoki (AUTHOR)
Bando, Takuma (AUTHOR)
Tani, Naoki (AUTHOR)
Chong, Yong (AUTHOR)
Ikematsu, Hideyuki (AUTHOR)
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Źródło:
Journal of Infection & Chemotherapy (Elsevier Inc.). Mar2024, Vol. 30 Issue 3, p266-270. 5p.
Czasopismo naukowe
Tytuł:
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment.
Autorzy:
Gobbi S; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Martini S; Molecular Pharmacology Unit, Fondazione IRCSS Istituto Nazionale dei Tumori, Via Amadeo 42, 20113 Milano, Italy.
Rozza R; National Research Council of Italy Institute of Materials (CNR-IOM) c/o SISSA, Via Bonomea 265, 34136 Trieste, Italy.
Spinello A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, 90128 Palermo, Italy.
Caciolla J; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Rampa A; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Belluti F; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Zaffaroni N; Molecular Pharmacology Unit, Fondazione IRCSS Istituto Nazionale dei Tumori, Via Amadeo 42, 20113 Milano, Italy.
Magistrato A; National Research Council of Italy Institute of Materials (CNR-IOM) c/o SISSA, Via Bonomea 265, 34136 Trieste, Italy.
Bisi A; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Mar 29; Vol. 28 (7). Date of Electronic Publication: 2023 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/drug therapy
Breast Neoplasms*/enzymology
Breast Neoplasms*/metabolism
Aromatase Inhibitors*/chemical synthesis
Aromatase Inhibitors*/chemistry
Aromatase Inhibitors*/pharmacology
Flavonoids*/chemical synthesis
Flavonoids*/chemistry
Flavonoids*/pharmacology
Drug Design*
Estrogen Receptor alpha*/antagonists & inhibitors
Estrogen Receptor alpha*/chemistry
Estrogen Receptor alpha*/metabolism
Aromatase*/chemistry
Aromatase*/metabolism
Humans ; Female ; Molecular Dynamics Simulation ; Thermodynamics ; Inhibitory Concentration 50 ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł:
Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens.
Autorzy:
Larsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. .
Engqvist H; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Biermann J; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Werner Rönnerman E; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Forssell-Aronsson E; Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Kovács A; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Karlsson P; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Helou K; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Parris TZ; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 02; Vol. 10 (1), pp. 5798. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Neoplasm*
Inhibitory Concentration 50*
Drug Screening Assays, Antitumor/*standards
Antineoplastic Agents/toxicity ; Bortezomib/toxicity ; Carboplatin/toxicity ; Cell Survival ; Cisplatin/toxicity ; Dimethyl Sulfoxide/standards ; Drug Screening Assays, Antitumor/methods ; Humans ; MCF-7 Cells ; Reproducibility of Results
Czasopismo naukowe
Tytuł:
Correlation between in vitro toxicity of pesticides and in vivo risk guidelines in support of complex operating site risk management: A meta-analysis.
Autorzy:
Alehashem M; Toxicology Centre, University of Saskatchewan, Saskatoon, Canada.
Mamet S; Department of Soil Science, University of Saskatchewan, Saskatoon, Canada.
Hogan N; Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; Department of Animal Science, University of Saskatchewan, Saskatoon, Canada.
Hecker M; Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; School of Environment and Sustainability, University of Saskatchewan, Saskatoon, Canada.
Florou D; Department of Forensic Medicine and Toxicology, University of Ioannina, Ioannina, Greece.
Tsatsakis A; Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
Siciliano S; Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; Department of Soil Science, University of Saskatchewan, Saskatoon, Canada. Electronic address: .
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Źródło:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Dec; Vol. 170, pp. 113502. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Meta-Analysis; Journal Article; Review
MeSH Terms:
Pesticides*/toxicity
Neuroblastoma*
Humans ; Inhibitory Concentration 50 ; Biological Assay ; Cell Line
Czasopismo naukowe
Tytuł:
Cytotoxic and nitric oxide inhibitory activities of triterpenoids from Lycopodium clavatum L.
Autorzy:
Giang VH; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Thuy LT; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam.
Hanh TTH; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Cuong NX; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Vinh LB; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; College of Pharmacy, Wonkwang University, Iksan, Republic of Korea.
Ban NK; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Linh TM; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Mai NC; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Huong TT; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam.
Dang NH; University of Science and Technology of Hanoi, VAST, Hanoi, Vietnam.
Oh H; College of Pharmacy, Wonkwang University, Iksan, Republic of Korea.
Lee DS; College of Pharmacy, Chosun University, Gwangju, Republic of Korea.
Quang TH; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
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Źródło:
Natural product research [Nat Prod Res] 2022 Dec; Vol. 36 (24), pp. 6232-6239. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Lycopodium*/chemistry
Triterpenes*/pharmacology
Triterpenes*/chemistry
Plants, Medicinal*/chemistry
Nitric Oxide/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Inhibitory Concentration 50
Czasopismo naukowe
Tytuł:
Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes .
Autorzy:
Prommaban A; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Sriyab S; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Marsup P; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.; Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Neimkhum W; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Huachiew Chalermprakiet University, Samutprakarn, Thailand.
Sirithunyalug J; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.
Anuchapreeda S; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
To-Anun C; Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, Chiang Mai, Thailand.
Chaiyana W; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 225-234.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Antioxidants/*pharmacology
Cordyceps/*chemistry
Enzyme Inhibitors/*pharmacology
Monophenol Monooxygenase/*antagonists & inhibitors
Animals ; Antioxidants/administration & dosage ; Antioxidants/isolation & purification ; Ascorbic Acid/pharmacology ; Catechin/analogs & derivatives ; Catechin/pharmacology ; Cattle ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/isolation & purification ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Free Radical Scavengers/administration & dosage ; Free Radical Scavengers/isolation & purification ; Free Radical Scavengers/pharmacology ; Fruiting Bodies, Fungal ; Inhibitory Concentration 50 ; Mycelium ; Skin/drug effects ; Skin/metabolism ; Skin Aging/drug effects ; Swine
SCR Organism:
Cordyceps tenuipes
Czasopismo naukowe
Tytuł:
Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo .
Autorzy:
Bai X; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.; Department of Spine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Jiang M; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Wang J; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Yang S; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.; Department of Spine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Liu Z; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Zhang H; Department of Orthopaedics, Baoding NO.1 Central Hospital, Baoding, China.
Zhu X; Department of Geratology, Baoding NO.1 Central Hospital, Baoding, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 427-436.
Typ publikacji:
Journal Article
MeSH Terms:
Anthocyanins/*pharmacology
Apoptosis/*drug effects
Intervertebral Disc Degeneration/*prevention & control
Nucleus Pulposus/*drug effects
Animals ; Anthocyanins/administration & dosage ; Dose-Response Relationship, Drug ; Inhibitory Concentration 50 ; Interleukin-1beta/administration & dosage ; Janus Kinase 2/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation.
Autorzy:
Niu B; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Wei S; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Sun J; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Zhao H; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Wang B; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Chen G; Department of Hepatobiliary and Pancreas Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 75-86.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Animals ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Benzylisoquinolines/administration & dosage ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Progression ; Drug Resistance, Neoplasm ; Humans ; Inhibitory Concentration 50 ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Network Pharmacology ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Sorafenib/administration & dosage ; TOR Serine-Threonine Kinases/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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