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Wyszukujesz frazę ""Inositol 1,4,5-trisphosphate"" wg kryterium: Temat


Tytuł :
Hydrogen peroxide depolarizes mitochondria and inhibits IP 3 -evoked Ca release in the endothelium of intact arteries.
Autorzy :
Zhang X; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
Lee MD; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
Wilson C; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
McCarron JG; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2019 Dec; Vol. 84, pp. 102108. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors*/metabolism
Endothelial Cells/*physiology
Hydrogen Peroxide/*metabolism
Mesenteric Arteries/*cytology
Mitochondria/*metabolism
Acetylcholine/metabolism ; Animals ; Calcium Signaling ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Cells, Cultured ; Feedback, Physiological ; Inositol 1,4,5-Trisphosphate/metabolism ; Membrane Potential, Mitochondrial ; Photolysis ; Rats
Czasopismo naukowe
Tytuł :
Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging.
Autorzy :
Ziegler DV; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Vindrieux D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Goehrig D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Jaber S; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Collin G; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Griveau A; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Wiel C; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Bendridi N; CarMeN Laboratory, INSERM UMR-1060, Lyon 1 University, INRA U1397, F-69921, Oullins, France.
Djebali S; Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Farfariello V; INSERM U1003, Laboratoire d'Excellence, Canaux Ioniques d'Intérêt Thérapeutique, Équipe Labellisée Par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
Prevarskaya N; INSERM U1003, Laboratoire d'Excellence, Canaux Ioniques d'Intérêt Thérapeutique, Équipe Labellisée Par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
Payen L; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Marvel J; Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Aubert S; Institut de Pathologie, Centre de Biologie Pathologie, CHRU de Lille, Faculté de Médecine, Université de Lille, Lille Cedex, France.
Flaman JM; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Rieusset J; CarMeN Laboratory, INSERM UMR-1060, Lyon 1 University, INRA U1397, F-69921, Oullins, France.
Martin N; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Bernard D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 01; Vol. 12 (1), pp. 720. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence/*physiology
Endoplasmic Reticulum/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Longevity/*physiology
Mitochondria/*metabolism
Animals ; Calcium/metabolism ; Endoplasmic Reticulum/ultrastructure ; Female ; Fibroblasts ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Male ; Mice ; Mice, Knockout ; Microscopy, Confocal ; Mitochondria/ultrastructure ; RNA, Small Interfering ; Refractory Period, Electrophysiological ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
IP 3 Receptor Plasticity Underlying Diverse Functions.
Autorzy :
Hamada K; Laboratory of Cell Calcium Signaling, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, 201210, China; email: , .
Mikoshiba K; Laboratory of Cell Calcium Signaling, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, 201210, China; email: , .
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Źródło :
Annual review of physiology [Annu Rev Physiol] 2020 Feb 10; Vol. 82, pp. 151-176. Date of Electronic Publication: 2019 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*physiology
Allosteric Regulation ; Animals ; Calcium Channels/metabolism ; Calcium Signaling ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate/physiology ; Inositol 1,4,5-Trisphosphate Receptors/genetics
Czasopismo naukowe
Tytuł :
Genetic analyses uncover pleiotropic compensatory roles for Drosophila Nucleobindin-1 in inositol trisphosphate-mediated intracellular calcium homeostasis.
Autorzy :
Balasubramanian V; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.
Srinivasan B; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.
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Źródło :
Genome [Genome] 2020 Feb; Vol. 63 (2), pp. 61-90. Date of Electronic Publication: 2019 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*metabolism
Calcium-Binding Proteins/*physiology
Drosophila Proteins/*physiology
Inositol 1,4,5-Trisphosphate Receptors/*genetics
Nucleobindins/*physiology
Alleles ; Amino Acid Motifs ; Animals ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drosophila Proteins/chemistry ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; GTP-Binding Protein alpha Subunits/metabolism ; Genes, Lethal ; Genetic Pleiotropy ; Golgi Apparatus/metabolism ; Homeostasis ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Mutation ; Nucleobindins/chemistry ; Nucleobindins/genetics ; Nucleobindins/metabolism ; Protein Domains ; Structural Homology, Protein
Czasopismo naukowe
Tytuł :
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.
Autorzy :
Argent L; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Winter F; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Prickett I; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Carrasquero-Ordaz M; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Olsen AL; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kramer H; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Lancaster E; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Becker EBE; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Sep 04; Vol. 295 (36), pp. 12716-12726. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Membrane Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Purkinje Cells/*metabolism
Animals ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Protein Domains ; Purkinje Cells/cytology
Czasopismo naukowe
Tytuł :
ORP4L couples IP 3 to ITPR1 in control of endoplasmic reticulum calcium release.
Autorzy :
Cao X; Department of Biology, Jinan University, Guangzhou, China.
Chen J; Department of Biology, Jinan University, Guangzhou, China.
Li D; Department of Biology, Jinan University, Guangzhou, China.
Xie P; Department of Biology, Jinan University, Guangzhou, China.
Xu M; Department of Biology, Jinan University, Guangzhou, China.
Lin W; Department of Biology, Jinan University, Guangzhou, China.
Li S; Department of Biology, Jinan University, Guangzhou, China.
Pan G; Department of Biology, Jinan University, Guangzhou, China.
Tang Y; Department of Biology, Jinan University, Guangzhou, China.
Xu J; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Olkkonen VM; Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland.
Yan D; Department of Biology, Jinan University, Guangzhou, China.
Zhong W; Department of Biology, Jinan University, Guangzhou, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Dec; Vol. 33 (12), pp. 13852-13865. Date of Electronic Publication: 2019 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Endoplasmic Reticulum/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Receptors, Steroid/*metabolism
Cell Line, Tumor ; Cell Membrane/metabolism ; Cell Survival/physiology ; Cytosol/metabolism ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Jurkat Cells ; Mitochondria/metabolism ; Oxidative Phosphorylation ; Phospholipase C beta/metabolism
Czasopismo naukowe
Tytuł :
Both d- and l-Glucose Polyphosphates Mimic d- myo -Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P 3 Receptor.
Autorzy :
Shipton ML; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K.
Riley AM; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K.
Rossi AM; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U. K.
Brearley CA; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U. K.
Taylor CW; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U. K.
Potter BVL; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5442-5457. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Partial Agonism*
Glucose/*chemistry
Inositol 1,4,5-Trisphosphate/*chemistry
Inositol 1,4,5-Trisphosphate Receptors/*agonists
Inositol 1,4,5-Trisphosphate Receptors/*chemistry
Molecular Mimicry/*drug effects
Polyphosphates/*chemistry
Animals ; Dose-Response Relationship, Drug ; Glucose/pharmacology ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate/pharmacology ; Molecular Docking Simulation/methods ; Molecular Mimicry/physiology ; Polyphosphates/pharmacology ; Protein Structure, Secondary ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Structure and Function of IP 3 Receptors.
Autorzy :
Prole DL; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
Taylor CW; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
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Źródło :
Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2019 Apr 01; Vol. 11 (4). Date of Electronic Publication: 2019 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*chemistry
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Calcium/metabolism ; Inositol 1,4,5-Trisphosphate/metabolism ; Signal Transduction ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Competitive Fluorescent Ligand Assay for Inositol 1,4,5-Trisphosphate.
Autorzy :
Tanimura A; Division of Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan. .
Shuto S; Laboratory of Organic Chemistry for Drug Development, Faculty of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2091, pp. 137-144.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate/*analysis
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Animals ; COS Cells ; Chlorocebus aethiops ; Fluorescence Resonance Energy Transfer ; Inositol 1,4,5-Trisphosphate/chemistry ; Inositol 1,4,5-Trisphosphate Receptors/chemistry ; Ligands ; Microscopy, Fluorescence ; Rats
Czasopismo naukowe
Tytuł :
C6-ceramide induces salivary adenoid cystic carcinoma cell apoptosis via IP3R-activated UPR and UPR-independent pathways.
Autorzy :
Qiu L; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Liu Z; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Wu C; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Chen W; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Chen Y; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Zhang B; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Li J; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Liu H; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Huang N; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Jiang Z; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Wu Y; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
Li L; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 May 14; Vol. 525 (4), pp. 997-1003. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Adenoid Cystic/*metabolism
Ceramides/*pharmacology
Endoplasmic Reticulum/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Salivary Gland Neoplasms/*metabolism
Unfolded Protein Response/*drug effects
Animals ; Apoptosis/genetics ; Calcium/metabolism ; Carcinoma, Adenoid Cystic/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Ceramides/administration & dosage ; Cytosol/drug effects ; Cytosol/metabolism ; Endoplasmic Reticulum/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Gene Silencing ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Ki-67 Antigen/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitochondrial Membranes/metabolism ; Oligonucleotide Array Sequence Analysis ; Salivary Gland Neoplasms/genetics ; Signal Transduction/genetics ; Unfolded Protein Response/genetics ; Xenograft Model Antitumor Assays ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
Di-n-butyl phthalate (DBP) reduces epithelial-mesenchymal transition via IP3R in hypospadias during maternal exposure.
Autorzy :
Zhu YP; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Zhao W; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Sun WL; Department of Geriatrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Zhao S; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Chen M; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Pan L; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Zhou Z; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Xia SJ; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: .
Jiang JT; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Apr 01; Vol. 192, pp. 110201. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*
Dibutyl Phthalate/*toxicity
Epithelial-Mesenchymal Transition/*drug effects
Hypospadias/*chemically induced
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Plasticizers/*toxicity
Animals ; Cadherins/genetics ; Cadherins/metabolism ; Calcium/metabolism ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Female ; Humans ; Hypospadias/genetics ; Hypospadias/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Male ; Maternal Exposure ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism ; Urethra/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
Autorzy :
Azumaya CM; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
Linton EA; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
Risener CJ; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
Nakagawa T; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.; Center for Structural Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.; Vanderbilt Brain Institute, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
Karakas E; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 .; Center for Structural Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Feb 07; Vol. 295 (6), pp. 1743-1753. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Peptides/*metabolism
Binding Sites ; Calcium Signaling ; Cryoelectron Microscopy ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/antagonists & inhibitors ; Inositol 1,4,5-Trisphosphate Receptors/chemistry ; Inositol 1,4,5-Trisphosphate Receptors/ultrastructure ; Models, Molecular ; Protein Conformation
Czasopismo naukowe
Tytuł :
Activation of mouse NBCe1-B by Xenopus laevis and mouse IRBITs: Role of the variable Nt appendage of IRBITs.
Autorzy :
Wang M; Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, Hubei 430074, China.
Wu H; Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, Hubei 430074, China.
Liu Y; Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, Hubei 430074, China. Electronic address: .
Chen LM; Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, Hubei 430074, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Jun 01; Vol. 1862 (6), pp. 183240. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate/*physiology
Sodium-Bicarbonate Symporters/*metabolism
Animals ; Inositol 1,4,5-Trisphosphate/metabolism ; Mice ; Peptide Fragments/pharmacology ; Protein Binding/drug effects ; Sodium-Bicarbonate Symporters/drug effects ; Xenopus Proteins/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Immunolocalization of IP3R and V-ATPase in Ameloblastomas.
Autorzy :
Giovanini AF; Medical School, Positivo University Curitiba, R Pedro Viriato Parigot de Souza, 5300 Campo Comprido, Curitiba, Paraná, 81280-330, Brazil. .
Priesnitz TF; Dentistry School, Positivo University Curitiba, Curitiba, Paraná, Brazil.
Til B; Dentistry School, Positivo University Curitiba, Curitiba, Paraná, Brazil.
Reisdoerfer G; Dentistry School, Positivo University Curitiba, Curitiba, Paraná, Brazil.
do Nascimento TCL; Medical School, Positivo University Curitiba, R Pedro Viriato Parigot de Souza, 5300 Campo Comprido, Curitiba, Paraná, 81280-330, Brazil.
Sobreiro B; Medical School, Positivo University Curitiba, R Pedro Viriato Parigot de Souza, 5300 Campo Comprido, Curitiba, Paraná, 81280-330, Brazil.
de Siqueira AS; Dentistry School, Positivo University Curitiba, Curitiba, Paraná, Brazil.
Pinheiro JJV; Department of Oral Pathology, School of Dentistry, Federal University of Pará, Belem, Brazil.
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Źródło :
Head and neck pathology [Head Neck Pathol] 2020 Jun; Vol. 14 (2), pp. 392-398. Date of Electronic Publication: 2019 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Ameloblastoma/*pathology
Biomarkers, Tumor/*analysis
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Jaw Neoplasms/*pathology
Vacuolar Proton-Translocating ATPases/*metabolism
Humans ; Immunohistochemistry ; Inositol 1,4,5-Trisphosphate Receptors/analysis ; Vacuolar Proton-Translocating ATPases/analysis
Czasopismo naukowe
Tytuł :
Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.
Autorzy :
Kim J; Genomic Instability Research Center, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Biomedical Sciences, The Graduate School of Ajou University, Suwon 16499, Korea.
Kim K; Genomic Instability Research Center, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Biomedical Sciences, The Graduate School of Ajou University, Suwon 16499, Korea.
Mo JS; Genomic Instability Research Center, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Biomedical Sciences, The Graduate School of Ajou University, Suwon 16499, Korea.
Lee Y; Genomic Instability Research Center, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Biomedical Sciences, The Graduate School of Ajou University, Suwon 16499, Korea.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Apr 17; Vol. 48 (7), pp. 3678-3691.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Cerebellar Ataxia/*genetics
Cerebellum/*metabolism
DNA Polymerase beta/*genetics
Inositol 1,4,5-Trisphosphate Receptors/*genetics
Animals ; Ataxia Telangiectasia Mutated Proteins/genetics ; Brain/embryology ; Brain/pathology ; Cerebellum/abnormalities ; Cerebellum/pathology ; Cytosine/metabolism ; DNA Damage ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Mice ; Mice, Knockout ; Neurogenesis/genetics
Czasopismo naukowe
Tytuł :
Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3.
Autorzy :
Wang J; Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100853, China.
Toan S; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA; Department of Chemical Engineering, University of Minnesota-Duluth, Duluth, MN 55812, USA.
Li R; Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100853, China.
Zhou H; Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100853, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Apr; Vol. 174, pp. 113832. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Calcium Channels/*metabolism
Cardio-Renal Syndrome/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Melatonin/*pharmacology
Mitochondrial Proteins/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Cardio-Renal Syndrome/drug therapy ; Cardio-Renal Syndrome/pathology ; Cells, Cultured ; Inositol 1,4,5-Trisphosphate Receptors/antagonists & inhibitors ; Male ; Melatonin/therapeutic use ; Mice ; Mice, Inbred C57BL ; Mitochondrial Proteins/antagonists & inhibitors ; Myocardium/metabolism ; Myocytes, Cardiac/drug effects ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Regulation of inositol 1,4,5-trisphosphate-induced Ca release from the endoplasmic reticulum by AMP-activated kinase modulators.
Autorzy :
Arias-Del-Val J; Institute of Biology and Molecular Genetics (IBGM), Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid and CSIC, Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Santo-Domingo J; Mitochondrial Function and Proteomics, Nestle Institute of Health Science S.A. EPFL Innovation Park, 1015, Lausanne, Switzerland.
García-Casas P; Institute of Biology and Molecular Genetics (IBGM), Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid and CSIC, Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Alvarez-Illera P; Institute of Biology and Molecular Genetics (IBGM), Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid and CSIC, Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Núñez Galindo A; Mitochondrial Function and Proteomics, Nestle Institute of Health Science S.A. EPFL Innovation Park, 1015, Lausanne, Switzerland.
Wiederkehr A; Mitochondrial Function and Proteomics, Nestle Institute of Health Science S.A. EPFL Innovation Park, 1015, Lausanne, Switzerland.
Fonteriz RI; Institute of Biology and Molecular Genetics (IBGM), Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid and CSIC, Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Montero M; Institute of Biology and Molecular Genetics (IBGM), Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid and CSIC, Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Alvarez J; Institute of Biology and Molecular Genetics (IBGM), Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid and CSIC, Ramón y Cajal, 7, E-47005 Valladolid, Spain. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2019 Jan; Vol. 77, pp. 68-76. Date of Electronic Publication: 2018 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP-Activated Protein Kinases*/antagonists & inhibitors
AMP-Activated Protein Kinases*/metabolism
Calcium/*metabolism
Calcium Signaling/*drug effects
Endoplasmic Reticulum/*metabolism
Inositol 1,4,5-Trisphosphate/*metabolism
Pyrazoles/*pharmacology
Pyrimidines/*pharmacology
Pyrones/*pharmacology
Thiophenes/*pharmacology
HeLa Cells ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/metabolism
Czasopismo naukowe
Tytuł :
Bcl-2 and IP 3 compete for the ligand-binding domain of IP 3 Rs modulating Ca signaling output.
Autorzy :
Ivanova H; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Wagner LE 2nd; University of Rochester Medical Center School of Medicine and Dentistry, 601 Elmwood Ave, Box 711, Rochester, NY, 14642, USA.
Tanimura A; Department of Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Kita-121757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.
Vandermarliere E; Center for Medical Biotechnology, VIB-UGent, 9000, Ghent, Belgium.; Department of Biochemistry, Ghent University, 9000, Ghent, Belgium.; Bioinformatics Institute Ghent, Ghent University, 9000, Ghent, Belgium.
Luyten T; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Welkenhuyzen K; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Alzayady KJ; University of Rochester Medical Center School of Medicine and Dentistry, 601 Elmwood Ave, Box 711, Rochester, NY, 14642, USA.
Wang L; University of Rochester Medical Center School of Medicine and Dentistry, 601 Elmwood Ave, Box 711, Rochester, NY, 14642, USA.
Hamada K; Lab Developmental Neurobiology, RIKEN Brain Science Institute, 2-1 Hirosawa Wako-Shi, 351-0198, Saitama, Japan.; SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, 393 Middle Huaxia Road, 201210, Shanghai, China.
Mikoshiba K; Lab Developmental Neurobiology, RIKEN Brain Science Institute, 2-1 Hirosawa Wako-Shi, 351-0198, Saitama, Japan.; SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, 393 Middle Huaxia Road, 201210, Shanghai, China.
De Smedt H; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Martens L; Center for Medical Biotechnology, VIB-UGent, 9000, Ghent, Belgium.; Department of Biochemistry, Ghent University, 9000, Ghent, Belgium.; Bioinformatics Institute Ghent, Ghent University, 9000, Ghent, Belgium.
Yule DI; University of Rochester Medical Center School of Medicine and Dentistry, 601 Elmwood Ave, Box 711, Rochester, NY, 14642, USA.
Parys JB; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Bultynck G; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 Oct; Vol. 76 (19), pp. 3843-3859. Date of Electronic Publication: 2019 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Signaling*
Inositol 1,4,5-Trisphosphate/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*antagonists & inhibitors
Proto-Oncogene Proteins c-bcl-2/*metabolism
Adenosine/analogs & derivatives ; Adenosine/metabolism ; Amino Acid Sequence ; Animals ; Binding, Competitive ; COS Cells ; Cells, Cultured ; Chlorocebus aethiops ; Inositol 1,4,5-Trisphosphate Receptors/agonists ; Inositol 1,4,5-Trisphosphate Receptors/chemistry ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Ligands ; Mice ; Molecular Docking Simulation ; Protein Domains ; Proto-Oncogene Proteins c-bcl-2/chemistry ; Sequence Deletion
Czasopismo naukowe
Tytuł :
Aberrant IP 3 receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29.
Autorzy :
Ando H; Laboratory for Developmental Neurobiology, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan .
Hirose M; Laboratory for Developmental Neurobiology, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan.
Mikoshiba K; Laboratory for Developmental Neurobiology, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Nov 27; Vol. 115 (48), pp. 12259-12264. Date of Electronic Publication: 2018 Nov 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*genetics
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Spinocerebellar Degenerations/*genetics
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Calcium/metabolism ; HeLa Cells ; Homeostasis ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Mutation ; Neurons/metabolism ; Protein Binding ; Spinocerebellar Degenerations/metabolism
SCR Disease Name :
Spinocerebellar Ataxia 29
Czasopismo naukowe
Tytuł :
De novo ITPR1 variants are a recurrent cause of early-onset ataxia, acting via loss of channel function.
Autorzy :
Synofzik M; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. .; German Research Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany. .
Helbig KL; Division of Clinical Genomics, Ambry Genetics, Aliso Viejo, CA, USA.
Harmuth F; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Deconinck T; Neurogenetics Group, VIB-Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium.
Tanpaiboon P; Division of Genetics and Metabolism, Children's National Health System, Washington, USA.
Sun B; Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Guo W; Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Wang R; Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Palmaer E; Division of Clinical Genomics, Ambry Genetics, Aliso Viejo, CA, USA.
Tang S; Division of Clinical Genomics, Ambry Genetics, Aliso Viejo, CA, USA.
Schaefer GB; Division of Medical Genetics, University of Arkansas for Medical Sciences, Little Rock, USA.
Gburek-Augustat J; Department of Neuropediatrics, Children's University Hospital, Tübingen, Germany.; Department of Paediatric Neurology and Metabolic Disorders, Centre for Paediatrics and Adolescent Medicine, Hannover Medical School, Hannover, Germany.
Züchner S; Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, USA.
Krägeloh-Mann I; Department of Neuropediatrics, Children's University Hospital, Tübingen, Germany.
Baets J; Neurogenetics Group, VIB-Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Edegem, Belgium.; Laboratories of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
de Jonghe P; Neurogenetics Group, VIB-Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Edegem, Belgium.; Laboratories of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Bauer P; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; Centogene AG, Rostock, Germany.
Chen SRW; Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Schöls L; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Research Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany.
Schüle R; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Research Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany.
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Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2018 Nov; Vol. 26 (11), pp. 1623-1634. Date of Electronic Publication: 2018 Jun 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Loss of Function Mutation*
Inositol 1,4,5-Trisphosphate Receptors/*genetics
Spinocerebellar Degenerations/*genetics
Calcium/metabolism ; Child ; Female ; HEK293 Cells ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Mutation, Missense ; Spinocerebellar Degenerations/pathology
SCR Disease Name :
Spinocerebellar Ataxia 29
Czasopismo naukowe

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