Temat: "Insulin" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Changes of insulin receptors in high fat and high glucose diet mice with insulin resistance.
Autorzy:: Lei C; Physiological Department, Xi'an Jiaotong University College of Medicine, Xi'an, China.; Department of geriatrics and special needs, General Hospital of Ningxia Medical University, Yinchuan, China.
Wang J; Research Office, General Hospital of Ningxia Medical University, Yinchuan, China.
Li X; Department of nutrition, General Hospital of Ningxia Medical University, Yinchuan, China.
Mao YY; Department of geriatrics and special needs, General Hospital of Ningxia Medical University, Yinchuan, China.
Yan JQ; Physiological Department, Xi'an Jiaotong University College of Medicine, Xi'an, China.; Pokaż więcej
Źródło:: Adipocyte [Adipocyte] 2023 Dec; Vol. 12 (1), pp. 2264444. Date of Electronic Publication: 2023 Oct 13.
Typ publikacji:: Journal Article
MeSH Terms:: Insulin Resistance*/physiology
Female ; Mice ; Animals ; Receptor, Insulin/genetics ; Receptor, Insulin/metabolism ; Insulin/metabolism ; Diet ; Glucose ; Diet, High-Fat/adverse effects

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Skocz do pozycji: 2.

Tytuł:: Pharmacokinetic and pharmacodynamic bioequivalence of Gan & Lee insulin analogues aspart (rapilin®), lispro (prandilin®) and glargine (basalin®) with EU- und US-sourced reference insulins.
Autorzy:: Chen W; Gan & Lee Pharmaceuticals, Beijing, China.
Lu J; Gan & Lee Pharmaceuticals US Corporations, Bridgewater, New Jersey, USA.
Plum-Mörschel L; Profil, Neuss, Germany.
Andersen G; Profil, Neuss, Germany.
Zijlstra E; Profil, Neuss, Germany.
He A; Gan & Lee Pharmaceuticals, Beijing, China.
Xie T; Gan & Lee Pharmaceuticals, Beijing, China.
Li L; Gan & Lee Pharmaceuticals, Beijing, China.
Hao C; Gan & Lee Pharmaceuticals, Beijing, China.
Gan Z; Gan & Lee Pharmaceuticals, Beijing, China.
Heise T; Profil, Neuss, Germany.; Pokaż więcej
Źródło:: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Dec; Vol. 25 (12), pp. 3817-3825. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Insulin*
Biosimilar Pharmaceuticals*/therapeutic use
Male ; Humans ; United States ; Insulin Glargine/adverse effects ; Insulin Lispro/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Therapeutic Equivalency ; Blood Glucose ; Insulin, Regular, Human ; Cross-Over Studies ; Double-Blind Method ; Insulin Aspart/adverse effects

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Skocz do pozycji: 3.

Tytuł:: The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance.
Autorzy:: Mahmoudi-Aznaveh A; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Tavoosidana G; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Najmabadi H; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Azizi Z; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ardestani A; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.; Pokaż więcej
Źródło:: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Nov 07; Vol. 14, pp. 1303930. Date of Electronic Publication: 2023 Nov 07 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Insulin Resistance*
Insulin-Secreting Cells*/metabolism
Exosomes*/metabolism
Diabetes Mellitus, Type 2*/metabolism
Humans ; Insulin/metabolism ; Receptor, Insulin/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Glucose/metabolism ; Gene Expression ; Liver/metabolism

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Skocz do pozycji: 4.

Tytuł:: Associations between insulin-like growth factor binding protein-2 and insulin sensitivity, metformin, and mortality in persons with T2D.
Autorzy:: Hjortebjerg R; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Denmark; Endocrine Research Unit, Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, Denmark. Electronic address: .
Kristiansen MR; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark; Danish Centre for Strategic Research in Type 2 Diabetes (DD2), Odense, Denmark.
Brandslund I; Department of Biochemistry and Immunology, University Hospital of Southern Denmark, Vejle, Denmark.
Aa Olsen D; Department of Biochemistry and Immunology, University Hospital of Southern Denmark, Vejle, Denmark.
Stidsen JV; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark; Endocrine Research Unit, Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, Denmark.
Nielsen JS; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Denmark; Danish Centre for Strategic Research in Type 2 Diabetes (DD2), Odense, Denmark.
Frystyk J; Department of Clinical Research, University of Southern Denmark, Denmark; Endocrine Research Unit, Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, Denmark.; Pokaż więcej
Źródło:: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2023 Nov; Vol. 205, pp. 110977. Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Type 2*/drug therapy
Metformin*/therapeutic use
Insulin Resistance*
Humans ; Insulin-Like Growth Factor Binding Protein 2 ; Glucose ; Insulin ; Insulin-Like Growth Factor I/metabolism

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Skocz do pozycji: 5.

Tytuł:: Targeting of insulin receptor endocytosis as a treatment to insulin resistance.
Autorzy:: Tim B; IUL Science Program, San Diego, CA, USA.
Kouznetsova VL; San Diego Supercomputer Center, University of California, San Diego, CA, USA; CureScience Institute, San Diego, CA, USA; BiAna, La Jolla, CA, USA.
Kesari S; Pacific Neuroscience Institute, Santa Monica, CA, USA.
Tsigelny IF; San Diego Supercomputer Center, University of California, San Diego, CA, USA; Department of Neurosciences, University of California, San Diego, CA, USA; CureScience Institute, San Diego, CA, USA; BiAna, La Jolla, CA, USA. Electronic address: .; Pokaż więcej
Źródło:: Journal of diabetes and its complications [J Diabetes Complications] 2023 Nov; Vol. 37 (11), pp. 108615. Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:: Journal Article
MeSH Terms:: Receptor, Insulin*/genetics
Receptor, Insulin*/metabolism
Insulin Resistance*/genetics
Humans ; Endocytosis/genetics ; Clathrin/metabolism ; Insulin/metabolism ; Transcription Factors/metabolism ; Glucose ; Homeodomain Proteins ; DNA-Binding Proteins/metabolism ; Calcium-Binding Proteins ; Trans-Activators

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Skocz do pozycji: 6.

Tytuł:: Pharmacological activation of insulin-degrading enzyme improves insulin secretion and glucose tolerance in diet-induced obese mice.
Autorzy:: Sanz-González A; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular (IBGM), Consejo Superior de Investigaciones Científicas (CSIC) y Universidad de Valladolid (UVa), Valladolid, Spain.
Cózar-Castellano I; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular (IBGM), Consejo Superior de Investigaciones Científicas (CSIC) y Universidad de Valladolid (UVa), Valladolid, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.
Broca C; Laboratory of Cell Therapy for Diabetes (LTCDPRIMS), IRMB Hop. St Eloi, CHU Montpellier, Montpellier, France.
Sabatier J; Laboratory of Cell Therapy for Diabetes (LTCDPRIMS), IRMB Hop. St Eloi, CHU Montpellier, Montpellier, France.
Acosta GA; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), Barcelona, Spain.; Department of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.; Department of Organic Chemistry, University of Barcelona, Barcelona, Spain.
Royo M; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), Barcelona, Spain.; Department of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
Hernándo-Muñoz C; Department of Chemistry, Faculty of Science, University of Burgos, Burgos, Spain.
Torroba T; Department of Chemistry, Faculty of Science, University of Burgos, Burgos, Spain.
Perdomo G; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular (IBGM), Consejo Superior de Investigaciones Científicas (CSIC) y Universidad de Valladolid (UVa), Valladolid, Spain.
Merino B; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular (IBGM), Consejo Superior de Investigaciones Científicas (CSIC) y Universidad de Valladolid (UVa), Valladolid, Spain.; Pokaż więcej
Źródło:: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Nov; Vol. 25 (11), pp. 3268-3278. Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Insulysin*/metabolism
Insulysin*/pharmacology
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/metabolism
Insulin-Secreting Cells*/metabolism
Islets of Langerhans*/metabolism
Mice ; Humans ; Animals ; Insulin Secretion ; Mice, Obese ; Glucose/metabolism ; Insulin/metabolism ; Diet, High-Fat/adverse effects

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Skocz do pozycji: 7.

Tytuł:: Insulin Receptor Substrates Regulation and Clinical Responses Following Vanadium-Enriched Yeast Supplementation in Obese Type 2 Diabetic Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Autorzy:: Ghalichi F; Faculty of Nutrition and Food Sciences, Department of Clinical Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Saghafi-Asl M; Nutrition Research Center, Drug Applied Research Center, Department of Clinical Nutrition, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Kafil B; Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Faghfouri AH; Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Jourshari MR; Faculty of Nutrition and Food Sciences, Department of Clinical Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Naserkiadeh AA; Faculty of Nutrition and Food Sciences, Department of Clinical Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Ostadrahimi A; Faculty of Nutrition and Food Sciences, Department of Clinical Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. .; Pokaż więcej
Źródło:: Biological trace element research [Biol Trace Elem Res] 2023 Nov; Vol. 201 (11), pp. 5169-5182. Date of Electronic Publication: 2023 Feb 24.
Typ publikacji:: Randomized Controlled Trial; Journal Article
MeSH Terms:: Insulin Resistance*
Yeast, Dried*
Diabetes Mellitus, Type 2*
Humans ; Vanadium/pharmacology ; Vanadium/therapeutic use ; Vanadium/metabolism ; Saccharomyces cerevisiae/metabolism ; Receptor, Insulin/metabolism ; Blood Glucose ; Leukocytes, Mononuclear/metabolism ; Quality of Life ; Insulin/metabolism ; Double-Blind Method ; Dietary Supplements

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Skocz do pozycji: 8.

Tytuł:: Diagnosis and treatment of anti-insulin antibody-mediated labile glycaemia in insulin-treated diabetes.
Autorzy:: Church DS; Department of Clinical Biochemistry and Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; The University of Cambridge MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.
Barker P; Core Biochemical Assay Laboratory, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Burling KA; Core Biochemical Assay Laboratory, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Shinwari SK; Diabetes & Endocrinology Centre, Birmingham Heartlands Hospital, Birmingham, UK.
Kennedy C; Department of Diabetes and Endocrinology, Beaumont Hospital, RCSI Medical School Dublin, Dublin, Ireland.
Smith D; Department of Diabetes and Endocrinology, Beaumont Hospital, RCSI Medical School Dublin, Dublin, Ireland.
Macfarlane DP; Department of Diabetes & Endocrinology, Raigmore Hospital, Inverness, UK.
Kernohan A; Department of Diabetes and Endocrinology, Queen Elizabeth University Hospital, Glasgow, UK.
Stears A; National Severe Insulin Resistance Service, Wolfson Diabetes & Endocrine Clinic, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Karamat MA; Diabetes & Endocrinology Centre, Birmingham Heartlands Hospital, Birmingham, UK.
Whyte K; West Glasgow Ambulatory Care Hospital, Glasgow, UK.
Narendran P; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, UK.
Halsall DJ; Department of Clinical Biochemistry and Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Semple RK; The University of Cambridge MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.; University of Edinburgh Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh, UK.; Pokaż więcej
Źródło:: Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2023 Nov; Vol. 40 (11), pp. e15194. Date of Electronic Publication: 2023 Sep 01.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus*
Hypoglycemia*/chemically induced
Insulin Resistance*
Hyperinsulinism*
Humans ; Insulin/therapeutic use ; Insulin Antibodies

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Skocz do pozycji: 9.

Tytuł:: Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder.
Autorzy:: Fernández-Pereira C; Translational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, Spain.; Neuro Epigenetics Lab, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, 15706 Santiago de Compostela, Spain.; Rare Disease and Pediatric Medicine Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Penedo MA; Translational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, Spain.
Rivera-Baltanás T; Translational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, Spain.
Pérez-Márquez T; Rare Disease and Pediatric Medicine Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Alves-Villar M; Rare Disease and Pediatric Medicine Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Fernández-Martínez R; Translational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, Spain.
Veiga C; Cardiovascular Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), 36213 Vigo, Spain.
Salgado-Barreira Á; Department of Preventive Medicine and Public Health, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, 15706 Santiago de Compostela, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP, 28029 Madrid, Spain.
Prieto-González JM; Neuro Epigenetics Lab, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, 15706 Santiago de Compostela, Spain.; Translational Research in Neurological Diseases Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, SERGAS-USC, 15706 Santiago de Compostela, Spain.; Neurology Service, Santiago University Hospital Complex, 15706 Santiago de Compostela, Spain.
Ortolano S; Rare Disease and Pediatric Medicine Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Olivares JM; Translational Neuroscience Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCIII, 36213 Vigo, Spain.
Agís-Balboa RC; Neuro Epigenetics Lab, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, 15706 Santiago de Compostela, Spain.; Translational Research in Neurological Diseases Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, SERGAS-USC, 15706 Santiago de Compostela, Spain.; Neurology Service, Santiago University Hospital Complex, 15706 Santiago de Compostela, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 17; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:: Journal Article
MeSH Terms:: Insulin-Like Growth Factor II*/metabolism
Depressive Disorder, Major*/drug therapy
Humans ; Rats ; Animals ; Mice ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor Binding Protein 5 ; Insulin-Like Growth Factor I/metabolism ; Anhedonia ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Insulin-Like Growth Factor Binding Protein 2

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Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance.
Autorzy:: Schaid MD; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Harrington JM; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Kelly GM; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Sdao SM; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Merrins MJ; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Kimple ME; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Pokaż więcej
Źródło:: Islets [Islets] 2023 Dec 31; Vol. 15 (1), pp. 2223327.
Typ publikacji:: Journal Article
MeSH Terms:: Islets of Langerhans*/metabolism
Diabetes Mellitus, Type 2*/metabolism
Insulin Resistance*
Mice ; Animals ; Insulin Secretion ; Glucose/pharmacology ; Glucose/metabolism ; Leptin/metabolism ; Leptin/pharmacology ; Insulin/metabolism ; Mice, Inbred C57BL ; Signal Transduction ; Obesity

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Skocz do pozycji: 11.

Tytuł:: Insulin resistance induced by long-term hyperinsulinemia abolishes the effects of acute insulin exposure on cell-surface nicotinic acetylcholine receptor levels and actin cytoskeleton morphology.
Autorzy:: García AP; Laboratorio de Neurobiología Molecular, Instituto de Investigaciones Biomédicas (BIOMED) UCA-CONICET, Facultad de Ciencias Médicas, Universidad Católica de Argentina, Buenos Aires, Argentina; Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral-CONICET, Santa Fe, Argentina.
Gaydou L; Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral-CONICET, Santa Fe, Argentina; Departamento de Bioquímica Clínica y Cuantitativa, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Pérez E; Laboratorio de Neurobiología Molecular, Instituto de Investigaciones Biomédicas (BIOMED) UCA-CONICET, Facultad de Ciencias Médicas, Universidad Católica de Argentina, Buenos Aires, Argentina.
Barrantes FJ; Laboratorio de Neurobiología Molecular, Instituto de Investigaciones Biomédicas (BIOMED) UCA-CONICET, Facultad de Ciencias Médicas, Universidad Católica de Argentina, Buenos Aires, Argentina. Electronic address: .; Pokaż więcej
Źródło:: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Dec 10; Vol. 685, pp. 149165. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Receptors, Nicotinic*/metabolism
Insulin Resistance*
Hyperinsulinism*
Cricetinae ; Animals ; CHO Cells ; Cricetulus ; Insulin/pharmacology ; Insulin/metabolism ; Actin Cytoskeleton/metabolism

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Skocz do pozycji: 12.

Tytuł:: Wheat germ peptide improves glucose metabolism and insulin resistance in HepG2 hepatocytes via regulating SOCS3/IRS1/Akt pathway.
Autorzy:: Song H; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China. Electronic address: .
Huang Q; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.
Zhang Y; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.
Shen X; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China. Electronic address: .; Pokaż więcej
Źródło:: Nutrition research (New York, N.Y.) [Nutr Res] 2023 Dec; Vol. 120, pp. 135-144. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Insulin Resistance*
Humans ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Triticum ; Insulin Receptor Substrate Proteins/metabolism ; Hexokinase/metabolism ; Hexokinase/pharmacology ; Pyruvate Kinase/metabolism ; Phosphoenolpyruvate/metabolism ; Phosphoenolpyruvate/pharmacology ; Hepatocytes/metabolism ; Glucose/metabolism ; Insulin/metabolism ; Glycogen/metabolism ; Suppressor of Cytokine Signaling 3 Protein/metabolism

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Skocz do pozycji: 13.

Tytuł:: Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
Autorzy:: Krejčová G; Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.
Morgantini C; Department of Medicine, Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden.
Zemanová H; Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.
Lauschke VM; Department of Medicine, Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden.; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.
Kovářová J; Biology Centre CAS, Institute of Parasitology, Ceske Budejovice, Czech Republic.
Kubásek J; Department of Experimental Plant Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.
Nedbalová P; Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.
Kamps-Hughes N; Institute of Molecular Biology, University of Oregon, Oregon City, OR, USA.
Moos M; Institute of Entomology, Biology Centre CAS, Ceske Budejovice, Czech Republic.
Aouadi M; Department of Medicine, Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden.
Doležal T; Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.
Bajgar A; Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.; Pokaż więcej
Źródło:: The EMBO journal [EMBO J] 2023 Dec 01; Vol. 42 (23), pp. e114086. Date of Electronic Publication: 2023 Oct 09.
Typ publikacji:: Journal Article
MeSH Terms:: Bacterial Infections*/metabolism
Insulin Resistance*
Drosophila Proteins*/metabolism
Animals ; Insulin Antagonists/metabolism ; Insulin Antagonists/pharmacology ; Drosophila/metabolism ; Insulin/metabolism ; Macrophages/metabolism ; Mammals ; Insulin-Like Growth Factor Binding Proteins/metabolism

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Skocz do pozycji: 14.

Tytuł:: Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene?
Autorzy:: Calcaterra V; Department of Internal Medicine, University of Pavia, Pavia, Italy.; Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
Zuccotti G; Pediatric Department, Buzzi Children's Hospital, Milan, Italy.; Department of Biomedical and Clinical Science, University of Milano, Milan, Italy.
Mari A; Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
Iafusco F; Department of Molecular Medicine and Medical Biotechnology, University of Napoli 'Federico II', Naples, Italy.; Department of Molecular Medicine and Medical Biotechnology, CEINGE Advanced Biotechnologies, Naples, Italy.
Maione G; Department of Molecular Medicine and Medical Biotechnology, University of Napoli 'Federico II', Naples, Italy.; Department of Molecular Medicine and Medical Biotechnology, CEINGE Advanced Biotechnologies, Naples, Italy.
Iafusco D; Department of Pediatrics, Regional Center of Pediatric Diabetology 'G.Stoppoloni', University of Campania 'Luigi Vanvitelli', Naples, Italy.
Tinto N; Department of Molecular Medicine and Medical Biotechnology, University of Napoli 'Federico II', Naples, Italy.; Department of Molecular Medicine and Medical Biotechnology, CEINGE Advanced Biotechnologies, Naples, Italy.; Pokaż więcej
Źródło:: Clinical obesity [Clin Obes] 2023 Dec; Vol. 13 (6), pp. e12619. Date of Electronic Publication: 2023 Sep 17.
Typ publikacji:: Case Reports
MeSH Terms:: Diabetes Mellitus*
Hyperinsulinism*/complications
Hyperinsulinism*/genetics
Insulin Resistance*/genetics
Obesity, Morbid*
Adolescent ; Female ; Humans ; Male ; Mutation ; Obesity/complications ; Obesity/genetics ; Receptor, Insulin/genetics ; Receptor, Insulin/metabolism

Raport

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Skocz do pozycji: 15.

Tytuł:: Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation.
Autorzy:: Kertisová A; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.; Department of Genetics and Microbiology, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic.
Žáková L; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Macháčková K; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Marek A; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Šácha P; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Pompach P; Institute of Biotechnology, Czech Academy of Sciences, Průmyslová 595, 252 50, Vestec, Czech Republic.
Jiráček J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Selicharová I; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.; Pokaż więcej
Źródło:: Open biology [Open Biol] 2023 Nov; Vol. 13 (11), pp. 230142. Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:: Journal Article
MeSH Terms:: Receptor, IGF Type 1*/genetics
Receptor, IGF Type 1*/chemistry
Receptor, IGF Type 1*/metabolism
Receptor, Insulin*/genetics
Receptor, Insulin*/chemistry
Receptor, Insulin*/metabolism
Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/chemistry ; Insulin-Like Growth Factor I/metabolism ; Ligands ; Cryoelectron Microscopy ; Insulin/metabolism

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 16.

Tytuł:: Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.
Autorzy:: Hendrix G; Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina, USA.
Lokhnygina Y; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.
Ramaker M; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA.
Ilkayeva O; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA.; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA.
Muehlbauer M; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA.
Evans W; University of California-Berkeley, Berkeley, California, USA.; Duke University, Durham, North Carolina, USA.
Rasbach L; Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina, USA.
Benjamin R; Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina, USA.
Freemark M; Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina, USA.; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA.
Gumus Balikcioglu P; Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina, USA.; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA.; Pokaż więcej
Źródło:: Endocrinology, diabetes & metabolism [Endocrinol Diabetes Metab] 2023 Nov; Vol. 6 (6), pp. e448. Date of Electronic Publication: 2023 Sep 16.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Diabetes Mellitus, Type 1*/drug therapy
Insulin Resistance*
Child ; Female ; Humans ; Male ; Amino Acids, Branched-Chain/metabolism ; Factor IX ; Fatty Acids/metabolism ; Glucose ; Glycemic Control ; Insulin/metabolism ; Insulin, Regular, Human

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 17.

Tytuł:: Deteriorating beta cell function is the dominant determinant of progression from normal glucose tolerance to prediabetes/diabetes in young women following pregnancy.
Autorzy:: Retnakaran R; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada. .; Division of Endocrinology, University of Toronto, Toronto, ON, Canada. .; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. .
Ye C; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.
Kramer CK; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Hanley AJ; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
Connelly PW; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Keenan Research Centre for Biomedical Science of St Michael's Hospital, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Sermer M; Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, ON, Canada.
Zinman B; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Endocrinology, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Pokaż więcej
Źródło:: Diabetologia [Diabetologia] 2023 Nov; Vol. 66 (11), pp. 2154-2163. Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Prediabetic State*
Insulin Resistance*
Diabetes Mellitus, Type 2*
Insulin-Secreting Cells*/physiology
Pregnancy ; Humans ; Female ; Glucose ; Blood Glucose/analysis ; Glucose Tolerance Test ; Insulin

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 18.

Tytuł:: Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter.
Autorzy:: Kanai A; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.
Nishida Y; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan. Electronic address: .
Iwamoto T; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.
Yokota M; Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Aoyama S; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.
Ueki K; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.
Ito M; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.
Uzawa H; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.
Iida H; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.
Koike M; Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Watada H; Department of Endocrinology & Metabolism, Juntendo University Graduate School of Medicine, Japan.; Pokaż więcej
Źródło:: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Oct 08; Vol. 676, pp. 132-140. Date of Electronic Publication: 2023 Jul 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Insulin*/metabolism
Insulin-Secreting Cells*/metabolism
Insulin Secretion ; Membrane Proteins/metabolism ; Coloring Agents/metabolism ; Secretory Vesicles/metabolism ; Cytoplasmic Granules/metabolism

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 19.

Tytuł:: Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease.
Autorzy:: Franceschi R; Pediatric Department, S. Chiara Hospital of Trento, APSS, 38121 Trento, Italy.
Fintini D; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Ravà L; Clinical Epidemiology, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Mariani M; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Aureli A; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Inzaghi E; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Pedicelli S; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Deodati A; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Bizzarri C; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Cappa M; Research Unit, Innovative Therapies for Endocrinopathies, Scientific Directorate, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.
Cianfarani S; Diabetes and Growth Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, 00168 Rome, Italy.; Department of Systems Medicine, University of Rome 'Tor Vergata', 00168 Rome, Italy.; Department of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Manco M; Research Unit of Predictive and Preventive Medicine, Bambino Gesù Children's Hospital, 00146 Rome, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 06; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:: Journal Article
MeSH Terms:: Prediabetic State*
Fatty Liver*
Insulin Resistance*
Male ; Female ; Humans ; Adolescent ; Insulin ; Obesity/metabolism ; Glucose ; Insulin, Regular, Human ; Blood Glucose/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 20.

Tytuł:: High incidence of skin reactions secondary to the use of adhesives in glucose sensors or insulin pumps for the treatment of children with type 1 diabetes.
Autorzy:: Genève P; Pediatric Endocrinology and Diabetology Unit, Children's Hospital, University Hospital of Nancy, France.
Adam T; Department of Allergology, Children's Hospital, University Hospital of Nancy, France.
Delawoevre A; Pediatric Endocrinology and Diabetology Unit, Children's Hospital, University Hospital of Nancy, France.
Jellimann S; Pediatric Endocrinology and Diabetology Unit, Children's Hospital, University Hospital of Nancy, France.
Legagneur C; Pediatric Endocrinology and Diabetology Unit, Children's Hospital, University Hospital of Nancy, France.
DiPatrizio M; Pediatric Endocrinology and Diabetology Unit, Children's Hospital, University Hospital of Nancy, France.
Renard E; Pediatric Endocrinology and Diabetology Unit, Children's Hospital, University Hospital of Nancy, France; INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, University of Lorraine, Nancy, France. Electronic address: .; Pokaż więcej
Źródło:: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2023 Oct; Vol. 204, pp. 110922. Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:: Observational Study; Journal Article
MeSH Terms:: Insulin*/adverse effects
Diabetes Mellitus, Type 1*/drug therapy
Diabetes Mellitus, Type 1*/epidemiology
Female ; Humans ; Child ; Male ; Hypoglycemic Agents/adverse effects ; Blood Glucose Self-Monitoring ; Incidence ; Retrospective Studies ; Blood Glucose ; Insulin, Regular, Human/therapeutic use ; Insulin Infusion Systems/adverse effects

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Insulin.