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Wyszukujesz frazę ""Insulin"" wg kryterium: Temat


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Tytuł:
H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes.
Autorzy:
Kumar A; CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India.; Academy of Scientific and Innovative Research, CSIR-HRDC, Kamala Nehru Nagar, Ghaziabad, 201002, Uttar Pradesh, India.
Datta M; CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India. .; Academy of Scientific and Innovative Research, CSIR-HRDC, Kamala Nehru Nagar, Ghaziabad, 201002, Uttar Pradesh, India. .
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Źródło:
Molecular medicine (Cambridge, Mass.) [Mol Med] 2022 Jul 16; Vol. 28 (1), pp. 81. Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/genetics
Diabetes Mellitus, Type 2*/metabolism
Insulin Resistance*
Histone Deacetylase 6/*metabolism
Insulin Receptor Substrate Proteins/*metabolism
RNA, Long Noncoding/*metabolism
Animals ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Insulin/metabolism ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; RNA, Long Noncoding/genetics ; RNA, Small Interfering
Czasopismo naukowe
Tytuł:
The pancreatic β-cell in ageing: Implications in age-related diabetes.
Autorzy:
Tudurí E; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain; Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, Spain. Electronic address: .
Soriano S; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain; Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, Spain.
Almagro L; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain.
Montanya E; Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Department of Clinical Sciences, University of Barcelona, Barcelona, Spain; Bellvitge Hospital-IDIBELL, Barcelona, Spain, University of Barcelona, Barcelona, Spain.
Alonso-Magdalena P; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain; Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
Nadal Á; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain; Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
Quesada I; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain; Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain. Electronic address: .
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Źródło:
Ageing research reviews [Ageing Res Rev] 2022 Sep; Vol. 80, pp. 101674. Date of Electronic Publication: 2022 Jun 17.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/metabolism
Insulin Resistance*
Insulin-Secreting Cells*/metabolism
Aging/metabolism ; Animals ; Humans ; Insulin/metabolism ; Insulin Secretion ; Mice
Czasopismo naukowe
Tytuł:
Comprehensive validation of fasting-based and oral glucose tolerance test-based indices of insulin secretion against gold standard measures.
Autorzy:
Prystupa K; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, Germany .; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tubingen, Germany.
Renklint R; Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
Chninou Y; Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
Otten J; Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
Fritsche L; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tubingen, Germany.
Hoerber S; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tubingen, Germany.; Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital of Tübingen, Tubingen, Germany.
Peter A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tubingen, Germany.; Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital of Tübingen, Tubingen, Germany.
Birkenfeld AL; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tubingen, Germany.
Fritsche A; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tubingen, Germany.
Heni M; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tubingen, Germany.; Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital of Tübingen, Tubingen, Germany.; Division of Endocrinology and Diabetology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Wagner R; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Medical Faculty, Department of Endocrinology and Diabetology, Heinrich Heine University, Düsseldorf, Germany.
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Źródło:
BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2022 Sep; Vol. 10 (5).
Typ publikacji:
Journal Article
MeSH Terms:
Fasting*
Insulin*/metabolism
C-Peptide ; Glucagon-Like Peptide 1 ; Glucose ; Glucose Tolerance Test ; Insulin Secretion ; Insulin, Regular, Human
Czasopismo naukowe
Tytuł:
Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar Insulin 70/30 with US-licensed HUMULIN® 70/30 formulation in healthy subjects: Results from the RHINE-3 (Recombinant Human INsulin Equivalence-3) study.
Autorzy:
Plum-Mörschel L; Profil, Mainz, Germany.
Klein O; Profil, Neuss, Germany.
Singh G; Biocon Biologics Ltd., Bengaluru, India.
Murugesan SMN; Biocon Biologics Ltd., Bengaluru, India.
Marwah A; Biocon Biologics Ltd., Bengaluru, India.
Sharma N; Biocon Biologics Ltd., Bengaluru, India.
Panda J; Biocon Biologics Ltd., Bengaluru, India.
Loganathan S; Biocon Biologics Ltd., Bengaluru, India.
Lakshmi GC; Biocon Biologics Ltd., Bengaluru, India.
Athalye SN; Biocon Biologics Ltd., Bengaluru, India.
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Źródło:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2022 Sep; Vol. 24 (9), pp. 1819-1828. Date of Electronic Publication: 2022 Jun 06.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Biosimilar Pharmaceuticals*/adverse effects
Biosimilar Pharmaceuticals*/pharmacokinetics
Insulin*
Area Under Curve ; Cross-Over Studies ; Double-Blind Method ; Healthy Volunteers ; Humans ; Insulin, Isophane ; Insulin, Regular, Human ; Recombinant Proteins ; Therapeutic Equivalency
Czasopismo naukowe
Tytuł:
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Autorzy:
Xu Y; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia.
Margetts MB; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia.
Venugopal H; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC 3800, Australia.
Menting JG; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia.
Kirk NS; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia.
Croll TI; Cambridge Institute for Medical Research, University of Cambridge, Keith Peters Building, Cambridge CB2 0XY, UK.
Delaine C; Discipline of Medical Biochemistry, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, SA 5042, Australia.
Forbes BE; Discipline of Medical Biochemistry, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, SA 5042, Australia.
Lawrence MC; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1098-1108.e6. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin-Like Growth Factor I*/metabolism
Receptor, Insulin*/chemistry
Receptor, Insulin*/metabolism
Cryoelectron Microscopy ; Cysteine ; Insulin/metabolism ; Ligands ; Receptor, IGF Type 1/chemistry ; Receptors, Somatomedin
Czasopismo naukowe
Tytuł:
Safety and efficacy of insulin detemir versus NPH in the treatment of diabetes during pregnancy: Systematic review and meta-analysis of randomized controlled trials.
Autorzy:
Athanasiadou KI; 2(nd) Department of Internal Medicine and Diabetes Centre, 417 Veteran's Fund Military Hospital NIMTS, Athens, Greece. Electronic address: .
Paschou SA; Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece.
Stamatopoulos T; Department of Neurosurgery, 401 General Military Hospital, Athens, Greece.
Papakonstantinou E; Department of Pediatric Oncology, Ippokratio General Hospital, Thessaloniki, Greece. Electronic address: .
Haidich AB; Department of Hygiene, Social-Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece. Electronic address: .
Goulis DG; Unit of Reproductive Endocrinology, 1(st) Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: .
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Źródło:
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2022 Aug; Vol. 190, pp. 110020. Date of Electronic Publication: 2022 Jul 22.
Typ publikacji:
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms:
Diabetes Mellitus, Type 1*
Insulin, Long-Acting*
Adult ; Female ; Humans ; Hypoglycemic Agents/adverse effects ; Insulin/adverse effects ; Insulin Detemir/adverse effects ; Insulin, Isophane/adverse effects ; Pregnancy ; Protamines ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł:
Dysregulated insulin secretion is associated with pancreatic β-cell hyperplasia and direct acinar-β-cell trans-differentiation in partially eNOS-deficient mice.
Autorzy:
Novelli M; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Masini M; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Vecoli C; Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Moscato S; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.; Interdepartmental Research Centre 'Nutraceuticals and Food for Health', University of Pisa, Pisa, Italy.
Funel N; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Pippa A; Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Mattii L; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.; Interdepartmental Research Centre 'Nutraceuticals and Food for Health', University of Pisa, Pisa, Italy.
Ippolito C; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Campani D; Department of Surgical, Medical and Molecular Pathology, and Critical Care Medicine, University of Pisa, Pisa, Italy.
Neglia D; Cardiovascular Department, Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica, Pisa, Italy.
Masiello P; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
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Źródło:
Physiological reports [Physiol Rep] 2022 Aug; Vol. 10 (16), pp. e15425.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin Resistance*
Insulin-Secreting Cells*/metabolism
Animals ; Blood Glucose/metabolism ; Cell Transdifferentiation ; Diet, High-Fat/adverse effects ; Glucose/metabolism ; Hyperplasia/metabolism ; Insulin/metabolism ; Insulin Secretion ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł:
Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review.
Autorzy:
de Sousa Melo SR; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina (Piauí), Brasil.
Dos Santos LR; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina (Piauí), Brasil.
da Cunha Soares T; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina (Piauí), Brasil.
Cardoso BEP; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina (Piauí), Brasil.
da Silva Dias TM; Graduate Program in Health Sciences Center, Federal University of Piauí, Teresina (Piauí), Brasil.
Morais JBS; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina (Piauí), Brasil.
de Paiva Sousa M; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina (Piauí), Brasil.
de Sousa TGV; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina (Piauí), Brasil.
da Silva NC; Graduate of Nutrition, Federal University of Piauí, Teresina Piauí, Brasil.
da Silva LD; Graduate of Nutrition, Federal University of Piauí, Teresina Piauí, Brasil.
Cruz KJC; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Rua Hugo Napoleão, 665, Ed. Palazzo Reale, Apto 2001, Jockey, CEP 64048-320, Teresina, Piauí, Brasil.
do Nascimento Marreiro D; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Rua Hugo Napoleão, 665, Ed. Palazzo Reale, Apto 2001, Jockey, CEP 64048-320, Teresina, Piauí, Brasil. .
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Źródło:
Biological trace element research [Biol Trace Elem Res] 2022 Aug; Vol. 200 (8), pp. 3545-3553. Date of Electronic Publication: 2022 Jun 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Insulin*/metabolism
Insulin Resistance*/physiology
Magnesium*/metabolism
Glucose/metabolism ; Humans ; Receptor, Insulin/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
β-cell function and insulin sensitivity contributions on incident diabetes in patients with endogenous Cushing's syndrome.
Autorzy:
Gong Z; Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Qin Y; Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Wang Y; Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Liu X; Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Jiang L; Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Cui D; Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Zhang M; Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. Electronic address: .
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Źródło:
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2022 Aug; Vol. 190, pp. 109994. Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Cushing Syndrome*/metabolism
Diabetes Mellitus, Type 2*/diagnosis
Insulin Resistance*
Insulin-Secreting Cells*/metabolism
Prediabetic State*/diagnosis
Blood Glucose/metabolism ; Glucose/metabolism ; Glucose Tolerance Test ; Humans ; Insulin/metabolism ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions.
Autorzy:
Salehi M; Division of Diabetes, University of Texas Health at San Antonio, San Antonio, TX 78229, USA.; South Texas Veteran Health Care System, Audie Murphy Hospital, San Antonio, TX 78229, USA.
DeFronzo R; Division of Diabetes, University of Texas Health at San Antonio, San Antonio, TX 78229, USA.
Gastaldelli A; Division of Diabetes, University of Texas Health at San Antonio, San Antonio, TX 78229, USA.; Cardiometabolic Risk Unit, CNR Institute of Clinical Physiology, 56124 Pisa, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 11; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 11.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/metabolism
Gastric Bypass*/methods
Insulin Resistance*
Obesity, Morbid*/metabolism
Blood Glucose/metabolism ; Fasting ; Gastrectomy/methods ; Humans ; Insulin/metabolism ; Insulin, Regular, Human
Czasopismo naukowe
Tytuł:
Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice.
Autorzy:
Tamas I; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Major E; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Horvath D; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Keller I; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Ungvari A; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Haystead TA; Duke University School of Medicine, Department of Pharmacology and Cancer Biology, Durham, NC, USA.
MacDonald JA; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Lontay B; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address: .
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Źródło:
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2022 Jul 01; Vol. 551, pp. 111663. Date of Electronic Publication: 2022 May 01.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin Resistance*/physiology
Muscle Proteins/*metabolism
Phosphoproteins/*metabolism
Animals ; Glucose/metabolism ; Insulin/metabolism ; Insulin Receptor Substrate Proteins/metabolism ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation
Czasopismo naukowe
Tytuł:
A low n-6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth.
Autorzy:
Tricò D; Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa.
Galderisi A; Hopital Necker-Enfants Malades, Paris, France.
Van Name MA; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Caprio S; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Samuels S; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Li Z; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Galuppo BT; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Savoye M; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Mari A; Institute of Neuroscience, National Research Council, Padua, Italy.
Feldstein AE; Department of Pediatrics, University of California San Diego, San Diego, California, USA.
Santoro N; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Medicine and Health Sciences, 'V.Tiberio' University of Molise, Campobasso, Italy.
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Źródło:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2022 Jul; Vol. 24 (7), pp. 1267-1276. Date of Electronic Publication: 2022 Apr 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Fatty Acids, Omega-3*
Hyperinsulinism*/etiology
Insulin Resistance*/physiology
Adolescent ; Blood Glucose/metabolism ; Diet ; Glucose ; Humans ; Insulin/metabolism ; Insulin, Regular, Human ; Obesity/complications ; Obesity/metabolism
Czasopismo naukowe
Tytuł:
Insulin secretion and action affect glucose variability in the early stages of glucose intolerance.
Autorzy:
Dimova R; Division of Diabetology, Department of Endocrinology, Medical University Sofia, Sofia, Bulgaria.
Chakarova N; Division of Diabetology, Department of Endocrinology, Medical University Sofia, Sofia, Bulgaria.
Daniele G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Bianchi C; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Dardano A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Del Prato S; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Tankova T; Division of Diabetology, Department of Endocrinology, Medical University Sofia, Sofia, Bulgaria.
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Źródło:
Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2022 Jul; Vol. 38 (5), pp. e3531. Date of Electronic Publication: 2022 Apr 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glucose Intolerance*
Insulin Resistance*/physiology
Adult ; Blood Glucose/analysis ; Glucose ; Glucose Tolerance Test ; Humans ; Insulin/metabolism ; Insulin Secretion ; Middle Aged
Czasopismo naukowe
Tytuł:
BMAL1 modulates ROS generation and insulin secretion in pancreatic β-cells: An effect possibly mediated via NOX2.
Autorzy:
de Jesus DS; Department of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo (USP), SP, Brazil; Centre for Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Bargi-Souza P; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Cruzat V; Faculty of Health, Torrens University, Melbourne, Victoria, Australia.
Yechoor V; Diabetes and Beta Cell Biology Center, Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, USA.
Carpinelli AR; Department of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo (USP), SP, Brazil.
Peliciari-Garcia RA; Department of Biological Sciences, Morphophysiology and Pathology Sector, Federal University of São Paulo (UNIFESP), Diadema, SP, Brazil. Electronic address: .
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Źródło:
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2022 Sep 15; Vol. 555, pp. 111725. Date of Electronic Publication: 2022 Jul 20.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin-Secreting Cells*
ARNTL Transcription Factors ; Animals ; Glucose ; Insulin ; Insulin Secretion ; Mice ; NADPH Oxidases ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł:
Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion.
Autorzy:
Yang L; Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Fye MA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Yang B; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Tang Z; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Zhang Y; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Haigh S; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Covington BA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Bracey K; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Taraska JW; Biochemistry and Biophysics Center, NHLBI, NIH, Bethesda, MD 20892, USA.
Kaverina I; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Qu S; Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China. Electronic address: .
Chen W; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: .
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Źródło:
Molecular metabolism [Mol Metab] 2022 Sep; Vol. 63, pp. 101541. Date of Electronic Publication: 2022 Jul 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Insulin-Secreting Cells*/metabolism
Exocytosis ; Glucose/metabolism ; Insulin/metabolism ; Insulin Secretion
Czasopismo naukowe
Tytuł:
The highly expressed calcium-insensitive synaptotagmin-11 and synaptotagmin-13 modulate insulin secretion.
Autorzy:
Ofori JK; Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Karagiannopoulos A; Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Barghouth M; Islet Pathophysiology, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Nagao M; Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden.; Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Andersson ME; Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Salunkhe VA; Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden.; Department of Physiology, Metabolism Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Zhang E; Islet Pathophysiology, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Wendt A; Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Eliasson L; Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
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Źródło:
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2022 Sep; Vol. 236 (1), pp. e13857. Date of Electronic Publication: 2022 Jul 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium*/metabolism
Insulin-Secreting Cells*/metabolism
Glucose/metabolism ; Humans ; Insulin/metabolism ; Insulin Secretion ; Synaptotagmins/genetics ; Synaptotagmins/metabolism
Czasopismo naukowe
Tytuł:
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression.
Autorzy:
Casteels T; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Bajew S; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Carrer del Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Carrer del Dr. Aiguader 88, 08003 Barcelona, Spain.
Reiniš J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Enders L; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Schuster M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Fontaine F; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Müller AC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
Wagner BK; Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria; Medical University of Vienna, Center for Medical Statistics, Informatics, and Intelligent Systems, Institute of Artificial Intelligence, 1090 Vienna, Austria.
Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Aug 30; Vol. 40 (9), pp. 111288.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin Assembly and Disassembly*
Glucagon-Secreting Cells*/metabolism
Insulin-Secreting Cells*/metabolism
Islets of Langerhans*/metabolism
RNA Splicing*/genetics
RNA Splicing Factors*/metabolism
SMN Complex Proteins*/metabolism
Animals ; Humans ; Insulin/metabolism ; Insulin Secretion ; Mice ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Magnesium increases insulin-dependent glucose uptake in adipocytes.
Autorzy:
Oost LJ; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Kurstjens S; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Laboratory of Clinical Chemistry and Hematology, Jeroen Bosch Hospital, 's-Hertogenbosch, Netherlands.
Ma C; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Beijing Tongren Hospital Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.
Hoenderop JGJ; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Tack CJ; Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
de Baaij JHF; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
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Źródło:
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Aug 25; Vol. 13, pp. 986616. Date of Electronic Publication: 2022 Aug 25 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/metabolism
Insulin Resistance*
Adipocytes/metabolism ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Insulin/pharmacology ; Magnesium ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Insulin/metabolism
Czasopismo naukowe
Tytuł:
Alternative to Sugar, Honey Does Not Provoke Insulin Resistance in Rats Based on Lipid Profiles, Inflammation, and IRS/PI3K/AKT Signaling Pathways Modulation.
Autorzy:
Chen S; College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China.
Wu F; College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China.
Yang C; College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China.
Zhao C; College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China.
Cheng N; College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China.; Bee Product Research Center of Shaanxi Province, Xi'an 710065, China.
Cao W; College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China.; Bee Product Research Center of Shaanxi Province, Xi'an 710065, China.
Zhao H; College of Food Science and Technology, Northwest University, 229 North TaiBai Road, Xi'an 710069, China.
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Źródło:
Journal of agricultural and food chemistry [J Agric Food Chem] 2022 Aug 24; Vol. 70 (33), pp. 10194-10208. Date of Electronic Publication: 2022 Aug 15.
Typ publikacji:
Journal Article
MeSH Terms:
Honey*
Insulin Resistance*/physiology
Animals ; Fructose ; Glucose/metabolism ; Inflammation ; Insulin/metabolism ; Lipids/pharmacology ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Receptor, Insulin/metabolism ; Signal Transduction ; Sugars
Czasopismo naukowe
Tytuł:
Photoacoustic imaging reveals mechanisms of rapid-acting insulin formulations dynamics at the injection site.
Autorzy:
Khadria A; Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Paavola CD; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Maslov K; Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Valenzuela FA; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Sperry AE; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Cox AL; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Cao R; Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Shi J; Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Brown-Augsburger PL; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Lozano E; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Blankenship RL; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Majumdar R; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Bradley SA; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Beals JM; Lilly Research Laboratories, Eli Lilly and Company, Lilly Biotechnology Center, San Diego, CA, 92121, USA. Electronic address: beals_john_.
Oladipupo SS; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA. Electronic address: oladipupo_sunday_.
Wang LV; Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA; Caltech Optical Imaging Laboratory, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. Electronic address: .
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Źródło:
Molecular metabolism [Mol Metab] 2022 Aug; Vol. 62, pp. 101522. Date of Electronic Publication: 2022 Jun 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin, Short-Acting*
Photoacoustic Techniques*
Animals ; Excipients ; Hypoglycemic Agents/chemistry ; Insulin ; Insulin Lispro ; Mice ; Swine
Czasopismo naukowe

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