Temat: "Insulin -- secretion" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation.
Autorzy :: Podraza-Farhanieh A; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden.
Natarajan B; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, SE901 85 Umeå, Sweden.
Raj D; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden.
Kao G; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden .
Naredi P; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden .; Department of Surgery, Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden.; Pokaż więcej
Źródło :: Development (Cambridge, England) [Development] 2020 Oct 27; Vol. 147 (20). Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Insulin Secretion*
Protein Processing, Post-Translational*
Sequence Homology, Amino Acid*
Caenorhabditis elegans Proteins/*metabolism
HSP70 Heat-Shock Proteins/*chemistry
Membrane Proteins/*chemistry
Proinsulin/*metabolism
Amino Acid Sequence ; Animals ; Caenorhabditis elegans/embryology ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/chemistry ; Cell Compartmentation ; Conserved Sequence ; Embryo, Nonmammalian/metabolism ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Green Fluorescent Proteins/metabolism ; Mutation/genetics ; Neurons/metabolism ; Protein Domains ; Protein Transport ; Secretory Vesicles
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Postprandial glycemia and insulin secretion following glutamine administration: A randomized controlled trial.
Autorzy :: Mansour A; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Mohajeri-Tehrani MR; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Qorbani M; Department of Biostatistics and Epidemiology, Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Ghamari M; Student Research Committee Faculty of Medical Urima, University of Medical Sciences, Uremia, Iran.
Larijani B; Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Hosseini S; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.; Pokaż więcej
Źródło :: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition [Int J Vitam Nutr Res] 2020 Oct; Vol. 90 (5-6), pp. 425-429. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :: Journal Article; Randomized Controlled Trial
MeSH Terms :: Diabetes Mellitus, Type 2*
Insulin Secretion*
Blood Glucose/metabolism ; Double-Blind Method ; Glutamine/metabolism ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/metabolism ; Insulin/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Caloric restriction recovers impaired β-cell-β-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice.
Autorzy :: Corezola do Amaral ME; Graduate Program in Biomedical Sciences, Centro Universitário da Fundação Hermínio Ometto, Araras, São Paulo, Brazil.
Kravets V; Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.
Dwulet JM; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.
Farnsworth NL; Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.
Piscopio R; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.
Schleicher WE; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.
Miranda JG; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.
Benninger RKP; Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Denver, Colorado.; Pokaż więcej
Źródło :: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Oct 01; Vol. 319 (4), pp. E709-E720. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Calcium Signaling*
Caloric Restriction*
Insulin Secretion*
Gap Junctions/*metabolism
Insulin-Secreting Cells/*metabolism
Prediabetic State/*metabolism
Animals ; Cell Communication ; Connexins/metabolism ; Diet, High-Fat ; Insulin Resistance ; Male ; Mice ; Mice, Inbred C57BL
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population.
Autorzy :: Fujita T; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Daimon M; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan. .
Mizushiri S; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Nishiya Y; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Murakami H; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Tanabe J; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Matsuhashi Y; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Yanagimachi M; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5-Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Tokuda I; Department of Oral Healthcare Science, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Sawada K; Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Ihara K; Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2020 Sep 25; Vol. 10 (1), pp. 15814. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Insulin Resistance*
Insulin Secretion*
Severity of Illness Index*
Diabetes Mellitus, Type 2/*pathology
Fibrosis/*physiopathology
Biomarkers/analysis ; Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/metabolism ; Female ; Follow-Up Studies ; Humans ; Japan/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Prognosis ; Risk Factors
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 5 5.

Tytuł :: GLP1R Single-Nucleotide Polymorphisms rs3765467 and rs10305492 Affect β Cell Insulin Secretory Capacity and Apoptosis Through GLP-1.
Autorzy :: Li W; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Li P; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Li R; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Yu Z; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Sun X; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Ji G; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Yang X; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Zhu L; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Zhu S; Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, China.; Pokaż więcej
Źródło :: DNA and cell biology [DNA Cell Biol] 2020 Sep; Vol. 39 (9), pp. 1700-1710. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :: Journal Article
MeSH Terms :: Apoptosis*
Insulin Secretion*
Polymorphism, Single Nucleotide*
Glucagon-Like Peptide-1 Receptor/*genetics
Insulin-Secreting Cells/*metabolism
Animals ; Cell Line ; Cells, Cultured ; Exenatide/pharmacology ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucose/metabolism ; Glucose/pharmacology ; Humans ; Insulin-Secreting Cells/drug effects ; Mice ; Mutation ; Rats
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1α Mutation Carriers.
Autorzy :: Christensen AS; Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Hædersdal S; Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Storgaard H; Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Rose K; Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Hansen NL; Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Holst JJ; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Knop FK; Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vilsbøll T; Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark .; Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Pokaż więcej
Źródło :: Diabetes [Diabetes] 2020 Sep; Vol. 69 (9), pp. 1989-2002. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :: Gastric Inhibitory Polypeptide/*pharmacology
Glucagon-Like Peptide 1/*pharmacology
Hepatocyte Nuclear Factor 1-alpha/*genetics
Hypoglycemic Agents/*pharmacology
Insulin Secretion/*drug effects
Sulfonylurea Compounds/*pharmacology
Adult ; Blood Glucose/drug effects ; Cross-Over Studies ; Double-Blind Method ; Female ; Glucose Clamp Technique ; Heterozygote ; Humans ; Insulin Secretion/genetics ; Male ; Mutation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: The magnesium transporter NIPAL1 is a pancreatic islet-expressed protein that conditionally impacts insulin secretion.
Autorzy :: Manialawy Y; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Khan SR; Department of Physiology, University of Toronto, Toronto, Ontario, Canada .; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Bhattacharjee A; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Wheeler MB; Department of Physiology, University of Toronto, Toronto, Ontario, Canada .; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Pokaż więcej
Źródło :: The Journal of biological chemistry [J Biol Chem] 2020 Jul 17; Vol. 295 (29), pp. 9879-9892. Date of Electronic Publication: 2020 May 21.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Insulin Secretion*
Cation Transport Proteins/*biosynthesis
Insulin-Secreting Cells/*metabolism
Magnesium/*metabolism
Animals ; Cation Transport Proteins/genetics ; Cell Line, Tumor ; Gene Expression Regulation ; Glucagon-Secreting Cells/cytology ; Glucagon-Secreting Cells/metabolism ; Insulin-Secreting Cells/cytology ; Male ; Mice
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Understanding nutrient-sensing at birth.
Autorzy :: Kriebs A; Associate Editor, Nature Communications, . .; Pokaż więcej
Źródło :: Nature reviews. Endocrinology [Nat Rev Endocrinol] 2020 Jul; Vol. 16 (7), pp. 344.
Typ publikacji :: Journal Article; Comment
MeSH Terms :: Glucose*
Insulin Secretion*
Humans ; Infant, Newborn ; Nutrients ; Signal Transduction
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Glucose-Stimulated Insulin Secretion Fundamentally Requires H 2 O 2 Signaling by NADPH Oxidase 4.
Autorzy :: Plecitá-Hlavatá L; Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Jabůrek M; Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Holendová B; Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Tauber J; Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Pavluch V; Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Berková Z; Institute of Clinical and Experimental Medicine, Prague, Czech Republic.
Cahová M; Institute of Clinical and Experimental Medicine, Prague, Czech Republic.
Schröder K; Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt, Germany.
Brandes RP; Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt, Germany.
Siemen D; Klinik für Neurologie, Universität Magdeburg, Magdeburg, Germany.
Ježek P; Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic .; Pokaż więcej
Źródło :: Diabetes [Diabetes] 2020 Jul; Vol. 69 (7), pp. 1341-1354. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Insulin Secretion*
Glucose/*pharmacology
Hydrogen Peroxide/*metabolism
NADPH Oxidase 4/*physiology
Animals ; Calcium/metabolism ; Cells, Cultured ; Insulin Resistance ; Mice ; Mice, Inbred C57BL ; Potassium Channels/physiology ; Signal Transduction/physiology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people.
Autorzy :: Płaczkowska S; Diagnostics Laboratory for Teaching and Research, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, Poland.
Pawlik-Sobecka L; Department of Laboratory Diagnostics, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, Poland.
Kokot I; Department of Laboratory Diagnostics, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, Poland.
Piwowar A; Department of Toxicology, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, Poland.; Pokaż więcej
Źródło :: Annals of agricultural and environmental medicine : AAEM [Ann Agric Environ Med] 2020 Jun 19; Vol. 27 (2), pp. 248-254. Date of Electronic Publication: 2019 Jun 18.
Typ publikacji :: Journal Article
MeSH Terms :: Insulin Resistance*
Insulin Secretion*
Adult ; Female ; Humans ; Male ; Poland ; Reference Values ; Young Adult
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.
Autorzy :: Wang Q; Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136.
Henry TAN; Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136.
Pronin AN; Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136.
Jang GF; Cole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Lubaczeuski C; Division of Endocrinology, Diabetes, and Metabolism, University of Miami School of Medicine, Miami, Florida 33136.
Crabb JW; Cole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Bernal-Mizrachi E; Division of Endocrinology, Diabetes, and Metabolism, University of Miami School of Medicine, Miami, Florida 33136.
Slepak VZ; Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136 .; Pokaż więcej
Źródło :: The Journal of biological chemistry [J Biol Chem] 2020 May 22; Vol. 295 (21), pp. 7213-7223. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Insulin Secretion*
MAP Kinase Signaling System*
GTP-Binding Protein beta Subunits/*metabolism
Glucose/*metabolism
Insulin-Secreting Cells/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Receptors, Neuropeptide/*metabolism
Animals ; Cell Line, Tumor ; GTP-Binding Protein beta Subunits/genetics ; Insulin-Secreting Cells/cytology ; Mice ; Mice, Knockout ; Receptors, G-Protein-Coupled/genetics ; Receptors, Neuropeptide/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: ER stress increases store-operated Ca entry (SOCE) and augments basal insulin secretion in pancreatic beta cells.
Autorzy :: Zhang IX; Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan Medical School, Ann Arbor, Michigan 48105.
Ren J; Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan Medical School, Ann Arbor, Michigan 48105.
Vadrevu S; Medtronic Minimed, Northridge, California 91324.
Raghavan M; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109.
Satin LS; Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan Medical School, Ann Arbor, Michigan 48105 .; Pokaż więcej
Źródło :: The Journal of biological chemistry [J Biol Chem] 2020 Apr 24; Vol. 295 (17), pp. 5685-5700. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Endoplasmic Reticulum Stress*
Insulin Secretion*
Calcium/*metabolism
Insulin-Secreting Cells/*metabolism
Animals ; Calcium Signaling ; Cations, Divalent/metabolism ; Cell Line ; Cells, Cultured ; Diabetes Mellitus, Type 2/metabolism ; Male ; Mice ; Rats
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Weight Loss Improves β-Cell Function in People With Severe Obesity and Impaired Fasting Glucose: A Window of Opportunity.
Autorzy :: Rothberg AE; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.; Department of Nutritional Sciences, University of Michigan, Ann Arbor, Michigan.
Herman WH; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Wu C; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
IglayReger HB; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Horowitz JF; Department of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Burant CF; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.; Department of Nutritional Sciences, University of Michigan, Ann Arbor, Michigan.
Galecki AT; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Halter JB; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.; Institute of Gerontology, University of Michigan, Ann Arbor, Michigan.; Pokaż więcej
Źródło :: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Apr 01; Vol. 105 (4).
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Insulin Secretion*
Weight Loss*
Glucose Intolerance/*prevention & control
Insulin-Secreting Cells/*physiology
Obesity, Morbid/*prevention & control
Biomarkers/analysis ; Case-Control Studies ; Diet, Carbohydrate-Restricted ; Female ; Follow-Up Studies ; Glucose Intolerance/physiopathology ; Humans ; Insulin-Secreting Cells/cytology ; Male ; Middle Aged ; Obesity, Morbid/physiopathology ; Prognosis
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: vH -ATPase-induced intracellular acidification is critical to glucose-stimulated insulin secretion in beta cells.
Autorzy :: Naik AR; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Formosa BJ; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Pulvender RG; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Liyanaarachchi AG; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Jena BP; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, USA. .; NanoBioScience Institute, Wayne State University, Detroit, MI, 48201, USA. .; Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, 540 E. Canfield, 5245 Scott Hall, Detroit, MI, 48201, USA. .; Pokaż więcej
Źródło :: Histochemistry and cell biology [Histochem Cell Biol] 2020 Apr; Vol. 153 (4), pp. 279-285. Date of Electronic Publication: 2020 Jan 04.
Typ publikacji :: Journal Article
MeSH Terms :: Insulin Secretion*/drug effects
Adenosine Triphosphatases/*metabolism
Glucose/*metabolism
Insulin-Secreting Cells/*metabolism
Adenosine Triphosphatases/antagonists & inhibitors ; Animals ; Cells, Cultured ; Glucose/antagonists & inhibitors ; Insulin-Secreting Cells/drug effects ; Macrolides/pharmacology ; Mice
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: A Toolbox for Translational Research on Beta Cell Function.
Autorzy :: Schulze T; Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany.
Rustenbeck I; Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany.; Pokaż więcej
Źródło :: Endocrinology [Endocrinology] 2020 Apr 01; Vol. 161 (4).
Typ publikacji :: Journal Article; Comment
MeSH Terms :: Insulin Secretion*
Insulin-Secreting Cells*
Calcium ; Cell Line ; Humans ; Insulin ; Translational Medical Research
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Loss of the voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.
Autorzy :: Pang H; Department of Biophysics, School of Physics Science, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China.
Wang X; Department of Biophysics, School of Physics Science, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China.
Zhao S; Institute of Molecular Medicine, Peking University, Beijing 100871, China.
Xi W; Department of Biophysics, School of Physics Science, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China.
Lv J; Department of Biophysics, School of Physics Science, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China.
Qin J; Department of Biophysics, School of Physics Science, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China.
Zhao Q; Department of Biophysics, School of Physics Science, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China.
Che Y; School of Medicine, Nankai University, Tianjin 300071, China.
Chen L; Institute of Molecular Medicine, Peking University, Beijing 100871, China .
Li SJ; Department of Biophysics, School of Physics Science, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China .; Pokaż więcej
Źródło :: The Journal of biological chemistry [J Biol Chem] 2020 Mar 13; Vol. 295 (11), pp. 3601-3613. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Insulin Secretion*
Glucose Intolerance/*complications
Glucose Intolerance/*metabolism
Hyperglycemia/*complications
Hyperglycemia/*metabolism
Ion Channels/*metabolism
Aging/pathology ; Animals ; Calcium/metabolism ; Calcium Signaling/drug effects ; Cell Size ; Cytoplasmic Granules/metabolism ; Cytoplasmic Granules/ultrastructure ; Cytosol/metabolism ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/pathology ; Down-Regulation/drug effects ; Gene Deletion ; Glucose/pharmacology ; Hydrogen-Ion Concentration ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/pathology ; Insulin-Secreting Cells/ultrastructure ; Ion Channels/deficiency ; Ion Channels/genetics ; Membrane Potentials ; Mice, Inbred C57BL ; Mice, Knockout ; Tetradecanoylphorbol Acetate/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells.
Autorzy :: Chen J; State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Wang F; Jiangsu Province Key Lab of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, China.
Zhou Y; Department of Thoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jiang J; Department of Hepatology, the First Hospital of Jilin University, Changchun 130021, China.
Ksimu S; The Center for Technology and Education, The First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, China.
Zhang X; Jiangsu Province Key Lab of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, China.
Li JZ; Jiangsu Province Key Lab of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, China.
Niu J; Department of Hepatology, the First Hospital of Jilin University, Changchun 130021, China.
Wang Q; Jiangsu Province Key Lab of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, China.; Pokaż więcej
Źródło :: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Mar 13; Vol. 134 (5), pp. 529-542.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Exocytosis*
Insulin Secretion*
Hepatitis C, Chronic/*metabolism
Insulin-Secreting Cells/*metabolism
Mitogen-Activated Protein Kinase 13/*metabolism
Animals ; Cell Line, Tumor ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism ; Glucose Intolerance/blood ; Glucose Intolerance/metabolism ; Glucose Intolerance/virology ; Hepatitis C, Chronic/virology ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/virology ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Transgenic ; Protein Kinase C/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Human Physiology of Genetic Defects Causing Beta-cell Dysfunction.
Autorzy :: Kettunen JLT; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland; Folkhalsan Research Center, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM) and Research Programs Unit (Clinical and Molecular Metabolism), University of Helsinki, Helsinki, Finland.
Tuomi T; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland; Folkhalsan Research Center, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM) and Research Programs Unit (Clinical and Molecular Metabolism), University of Helsinki, Helsinki, Finland; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Malmö, SE-20513, Sweden. Electronic address: .; Pokaż więcej
Źródło :: Journal of molecular biology [J Mol Biol] 2020 Mar 06; Vol. 432 (5), pp. 1579-1598. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :: Diabetes Mellitus, Type 2*/genetics
Diabetes Mellitus, Type 2*/physiopathology
Insulin Resistance*/genetics
Insulin Resistance*/physiology
Insulin Secretion*/genetics
Insulin Secretion*/physiology
Insulin-Secreting Cells*/pathology
Insulin-Secreting Cells*/physiology
Genetic Predisposition to Disease ; Humans ; Insulin/metabolism ; Physiology/methods
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Recent Insights into Beta-cell Exocytosis in Type 2 Diabetes.
Autorzy :: Thurmond DC; Department of Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, CA, USA. Electronic address: .
Gaisano HY; Department of Medicine, University of Toronto, ON, Canada. Electronic address: .; Pokaż więcej
Źródło :: Journal of molecular biology [J Mol Biol] 2020 Mar 06; Vol. 432 (5), pp. 1310-1325. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :: Insulin Secretion*
Diabetes Mellitus, Type 2/*metabolism
Insulin-Secreting Cells/*pathology
SNARE Proteins/*metabolism
Animals ; Diabetes Mellitus, Type 2/prevention & control ; Exocytosis ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/cytology ; Islets of Langerhans/metabolism ; Munc18 Proteins/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models.
Autorzy :: Dissanayake WC; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand.
Sorrenson B; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand.
Lee KL; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand.
Barre S; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Shepherd PR; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand.; Pokaż więcej
Źródło :: The Biochemical journal [Biochem J] 2020 Feb 28; Vol. 477 (4), pp. 763-772.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Insulin Secretion*
Gene Expression Regulation/*drug effects
Glucose/*pharmacology
Insulin-Secreting Cells/*metabolism
Sweetening Agents/*pharmacology
alpha Catenin/*metabolism
Animals ; Cells, Cultured ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Protein Isoforms ; Rats ; alpha Catenin/genetics
: Czasopismo naukowe

Szczegóły

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