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Wyświetlanie 1-20 z 20295
Tytuł:
Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells.
Autorzy:
Udagawa H; Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, 162-8655, Japan.; Department of Registered Dietitians, Faculty of Health and Nutrition, Bunkyo University, 1100 Namegaya, Chigasaki, Kanagawa, 253-8550, Japan.
Funahashi N; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Nishimura W; Department of Molecular Biology, International University of Health and Welfare School of Medicine, Narita, Chiba, 286-8686, Japan.; Division of Anatomy, Bio-Imaging and Neuro-Cell Science, Jichi Medical University, Shimotsuke, Tochigi, 329-0498, Japan.
Uebanso T; Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.
Kawaguchi M; Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, 162-8655, Japan.
Asahi R; Department of Registered Dietitians, Faculty of Health and Nutrition, Bunkyo University, 1100 Namegaya, Chigasaki, Kanagawa, 253-8550, Japan.
Nakajima S; Department of Registered Dietitians, Faculty of Health and Nutrition, Bunkyo University, 1100 Namegaya, Chigasaki, Kanagawa, 253-8550, Japan.
Nammo T; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.; Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Hiramoto M; Department of Biochemistry, Tokyo Medical University, Tokyo, 160-8402, Japan.
Yasuda K; Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, 162-8655, Japan. .; Department of Diabetes, Endocrinology and Metabolism, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 20; Vol. 13 (1), pp. 17958. Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin Secretion*
Insulin-Secreting Cells*/metabolism
Receptors, Glucocorticoid*/metabolism
Animals ; Mice ; Rats ; Chromatography, Liquid ; Corticosterone/metabolism ; Glucose/metabolism ; Hydrocortisone/metabolism ; Insulin/metabolism ; Islets of Langerhans/metabolism ; Obesity/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Short-term recovery of insulin secretion in response to a meal is associated with future glycemic control in type 2 diabetes patients.
Autorzy:
Enkaku A; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
Chujo D; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.; Center for Clinical Research, Toyama University Hospital, Toyama, Japan.
Kamigishi M; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
Inagawa S; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
Matsukoshi S; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
Sakai W; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
Takikawa A; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
Fujisaka S; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
Tobe K; Department of Diabetes, Metabolism, and Endocrinology, Toyama University Hospital, Toyama, Japan.
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Źródło:
Journal of diabetes investigation [J Diabetes Investig] 2024 Apr; Vol. 15 (4), pp. 437-448. Date of Electronic Publication: 2023 Dec 27.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*
Humans ; Insulin Secretion ; Insulin/metabolism ; Glycated Hemoglobin ; C-Peptide/metabolism ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Glycemic Control ; Glucose ; Postprandial Period/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biospeciation of Oxidovanadium(IV) Imidazolyl-Carboxylate Complexes and Their Action on Glucose-Stimulated Insulin Secretion in Pancreatic Cells.
Autorzy:
Ugirinema V; Department of Chemistry, Nelson Mandela University, P.O. Box 77000, Port Elizabeth 6031, South Africa.; Department of Chemistry, College of Science and Technology, University of Rwanda, Kigali P.O. Box 3900, Rwanda.
Odei-Addo F; Department of Biochemistry and Microbiology, Nelson Mandela University, P.O. Box 77000, Port Elizabeth 6031, South Africa.
Frost CL; Department of Biochemistry and Microbiology, Nelson Mandela University, P.O. Box 77000, Port Elizabeth 6031, South Africa.
Tshentu ZR; Department of Chemistry, Nelson Mandela University, P.O. Box 77000, Port Elizabeth 6031, South Africa.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 04; Vol. 29 (3). Date of Electronic Publication: 2024 Feb 04.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*
Hyperglycemia*
Humans ; Insulin Secretion ; Vanadium/pharmacology ; Vanadium/chemistry ; Glucose ; Insulin/metabolism ; Citric Acid ; Imidazoles/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Whole transcriptome sequencing analyses of islets reveal ncRNA regulatory networks underlying impaired insulin secretion and increased β-cell mass in high fat diet-induced diabetes mellitus.
Autorzy:
Ma J; Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.; Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, China.
Gao R; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Xie Q; Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.; Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, China.
Pan X; Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.; Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, China.
Tong N; Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.; Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, China.
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Źródło:
PloS one [PLoS One] 2024 Apr 01; Vol. 19 (4), pp. e0300965. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Diabetes Mellitus*
Mice ; Animals ; Diet, High-Fat/adverse effects ; RNA, Circular/metabolism ; Insulin Secretion ; Exome Sequencing ; Mice, Inbred C57BL ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Obesity/genetics ; Gene Regulatory Networks ; Calcium Channels, N-Type/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The importance of intravenous glucose tolerance test glucose stimulus for the evaluation of insulin secretion.
Autorzy:
Godsland IF; Division of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK. .; Wynn Reader in Human Metabolism, Section of Metabolic Medicine, Faculty of Medicine, Imperial College London (St Mary's Campus), Room G1, Norfolk Place, London, W2 2NH, UK. .
Johnston DG; Division of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Department of Diabetes and Endocrinology, St Marys Hospital, Imperial College Healthcare NHS Trust, London, UK.
Alberti K; Division of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Oliver N; Division of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Department of Diabetes and Endocrinology, St Marys Hospital, Imperial College Healthcare NHS Trust, London, UK.
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 28; Vol. 14 (1), pp. 7451. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Blood Glucose*/metabolism
Insulin Resistance*
Humans ; Glucose Tolerance Test ; Insulin Secretion ; Insulin/metabolism ; Glucose ; Obesity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insulin Secretion Defect in Children and Adolescents with Obesity: Clinical and Molecular Genetic Characterization.
Autorzy:
Enders-Seidlitz H; Charité Universitätsmedizin Berlin, Berlin, Germany.
Raile K; Vivantes Klinikum, Berlin, Germany.
Gong M; Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Galler A; Charité Universitätsmedizin Berlin, Berlin, Germany.
Kuehnen P; Charité Universitätsmedizin Berlin, Berlin, Germany.
Wiegand S; Charité Universitätsmedizin Berlin, Berlin, Germany.
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Źródło:
Journal of diabetes research [J Diabetes Res] 2024 Mar 20; Vol. 2024, pp. 5558634. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Pediatric Obesity*/genetics
Insulin Resistance*/genetics
Diabetes Mellitus, Type 2*/metabolism
Humans ; Child ; Adolescent ; Insulin Secretion ; Insulin/metabolism ; Glucose ; Molecular Biology ; Blood Glucose/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice.
Autorzy:
Tanaka C; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Harada N; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan. .; Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University, 1-1 Gakuencho, Naka-ku, Sakai, Osaka, 599-8531, Japan. .
Teraoka Y; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Urushizaki H; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Shinmori Y; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Onishi T; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Yotsumoto Y; Natural Materials Laboratory, Saraya Company, Ltd., 24-12 Tamatecho, Kashiwara, 582-0028, Kashiwara, Osaka, Japan.
Ito Y; Natural Materials Laboratory, Saraya Company, Ltd., 24-12 Tamatecho, Kashiwara, 582-0028, Kashiwara, Osaka, Japan.
Kitakaze T; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.; Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University, 1-1 Gakuencho, Naka-ku, Sakai, Osaka, 599-8531, Japan.
Inui T; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.; Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University, 1-1 Gakuencho, Naka-ku, Sakai, Osaka, 599-8531, Japan.
Murata Y; Natural Materials Laboratory, Saraya Company, Ltd., 24-12 Tamatecho, Kashiwara, 582-0028, Kashiwara, Osaka, Japan.
Inui H; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.; Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University, 1-1 Gakuencho, Naka-ku, Sakai, Osaka, 599-8531, Japan.; Department of Health and Nutrition, Otemae University, Osaka, Osaka, Japan.
Yamaji R; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.; Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University, 1-1 Gakuencho, Naka-ku, Sakai, Osaka, 599-8531, Japan.; Center for Research and Development of Bioresources, Osaka Metropolitan University, Sakai, Osaka, Japan.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 08; Vol. 14 (1), pp. 3244. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Experimental*/metabolism
Hyperglycemia*/drug therapy
Lanosterol*/analogs & derivatives
Phenanthrenes*
Animals ; Mice ; Bile Acids and Salts ; GTP-Binding Proteins/metabolism ; Insulin/metabolism ; Insulin Secretion ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Congenital Hyperinsulinism in Humans and Insulin Secretory Dysfunction in Mice Caused by Biallelic DNAJC3 Variants.
Autorzy:
Welters A; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.; Institute of Metabolic Physiology, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Nortmann O; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.; Institute of Metabolic Physiology, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Wörmeyer L; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.; Institute of Metabolic Physiology, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Freiberg C; Department of Pediatrics and Adolescent Medicine, Pediatric Endocrinology, University Medicine Göttingen, D-37075 Göttingen, Germany.
Eberhard D; Institute of Metabolic Physiology, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Bachmann N; Medizinische Genetik Mainz, Limbach Genetics, D-55128 Mainz, Germany.
Bergmann C; Medizinische Genetik Mainz, Limbach Genetics, D-55128 Mainz, Germany.
Mayatepek E; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Meissner T; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Kummer S; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Congenital Hyperinsulinism*/genetics
HSP40 Heat-Shock Proteins*/genetics
HSP40 Heat-Shock Proteins*/metabolism
Adolescent ; Animals ; Humans ; Mice ; Calcium/metabolism ; Insulin/metabolism ; Insulin Secretion ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery.
Autorzy:
Visentin R; Department of Information Engineering, University of Padova, Padova, Italy.
Brodersen K; Department of Surgery, Viborg General Hospital, Denmark.
Richelsen B; Steno Diabetes Center Aarhus, Aarhus University Hospital & Clinical Medicine, Aarhus University, Denmark.
Møller N; Steno Diabetes Center Aarhus, Aarhus University Hospital & Clinical Medicine, Aarhus University, Denmark.
Dalla Man C; Department of Information Engineering, University of Padova, Padova, Italy.
Pedersen AK; Department of Clinical Research, University Hospital of Southern Denmark, Denmark.
Abrahamsen J; Department of Radiology, Viborg General Hospital, Denmark.
Holst JJ; Novo Nordisk Foundation, Center of Basic Metabolic Research and Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Denmark.
Nielsen MF; Department of Surgery, University Hospital of Southern Denmark, Denmark.
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Źródło:
Journal of diabetes research [J Diabetes Res] 2023 Nov 14; Vol. 2023, pp. 7127426. Date of Electronic Publication: 2023 Nov 14 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Insulin Resistance*/physiology
Diabetes Mellitus, Type 2*
Bariatric Surgery*
Gastric Bypass*/methods
Humans ; Glucose/metabolism ; Insulin Secretion ; Blood Glucose/metabolism ; Obesity/complications ; Obesity/surgery ; Obesity/metabolism ; Insulin ; Glucagon-Like Peptide 1 ; Gastrectomy/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets.
Autorzy:
Vaganova AN; Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.; St. Petersburg State University Hospital, St. Petersburg State University, 199034 St. Petersburg, Russia.
Shemyakova TS; Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.
Lenskaia KV; Department of Medicine, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, Russia.
Rodionov RN; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Steenblock C; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Gainetdinov RR; Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.; St. Petersburg State University Hospital, St. Petersburg State University, 199034 St. Petersburg, Russia.
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Źródło:
Biomolecules [Biomolecules] 2023 Nov 05; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 05.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Metabolic Syndrome*/metabolism
Islets of Langerhans*/metabolism
Humans ; Insulin Secretion ; Amines/metabolism ; Signal Transduction ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Delineating the transcriptional atlas for impaired insulin secretion: A window into type 2 diabetes pathophysiology.
Autorzy:
Li J; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.
Yang J; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Hong T; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
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Źródło:
Journal of diabetes investigation [J Diabetes Investig] 2023 Nov; Vol. 14 (11), pp. 1231-1233. Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/genetics
Glucose Intolerance*
Insulin Resistance*
Humans ; Insulin Secretion ; Insulin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of nutrient metabolism on pancreatic β-cell mass and function: Recent findings.
Autorzy:
Yasuda T; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Harada N; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło:
Journal of diabetes investigation [J Diabetes Investig] 2023 Nov; Vol. 14 (11), pp. 1234-1236. Date of Electronic Publication: 2023 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/metabolism
Insulin-Secreting Cells*/metabolism
Humans ; Insulin/metabolism ; Insulin Secretion ; Nutrients
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Short-Term Inhibition of Translation by Cycloheximide Concurrently Affects Mitochondrial Function and Insulin Secretion in Islets from Female Mice.
Autorzy:
Alshafei M; Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, D38106 Braunschweig, Germany.
Schulze T; Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, D38106 Braunschweig, Germany.
Morsi M; Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, D38106 Braunschweig, Germany.; Department of Pharmacology, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Panten U; Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, D38106 Braunschweig, Germany.
Rustenbeck I; Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, D38106 Braunschweig, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 23; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:
Journal Article
MeSH Terms:
Islets of Langerhans*/metabolism
Mice ; Female ; Animals ; Insulin Secretion ; Cycloheximide/pharmacology ; Insulin/metabolism ; Glucose/metabolism ; Tolbutamide/pharmacology ; Tolbutamide/metabolism ; NAD/metabolism ; Mitochondria/metabolism ; Calcium/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2 /CaMK2 signaling pathway.
Autorzy:
Li Y; Department of Pathophysiology, School of Basic Medicine of Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Li R; Department of Pathophysiology, School of Basic Medicine of Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Luo X; Department of Pathophysiology, School of Basic Medicine of Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Xu F; Department of Pathophysiology, School of Basic Medicine of Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Yang M; Department of Pharmacology, School of Basic Medicine of Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Zheng L; The First School of Clinical Medicine, Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Wu Q; The First School of Clinical Medicine, Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Jiang W; Department of Pharmacy, Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
Li Y; Department of Pathophysiology, School of Basic Medicine of Binzhou Medical University, Yantai, Shandong 264000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2023 Oct; Vol. 28 (4). Date of Electronic Publication: 2023 Sep 08.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*
Insulin-Secreting Cells*
Craniocerebral Trauma*
Animals ; Mice ; Insulin Secretion ; Vascular Endothelial Growth Factor B ; Signal Transduction ; Dependovirus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mitochondrial Dynamics and Insulin Secretion.
Autorzy:
Kabra UD; Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Parul University, Vadodara 391760, India.
Jastroch M; The Arrhenius Laboratories F3, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 07; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Diabetes Mellitus, Type 2*
Humans ; Insulin Secretion ; Mitochondrial Dynamics ; Apoptosis ; Mitochondrial Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A data integration approach unveils a transcriptional signature of type 2 diabetes progression in rat and human islets.
Autorzy:
Cao S; National Center of Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China.; University of the Chinese Academy of Sciences, Beijing, China.
Wang L; National Center of Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China.; University of the Chinese Academy of Sciences, Beijing, China.
Feng Y; National Center of Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China.; University of the Chinese Academy of Sciences, Beijing, China.
Peng XD; Department of Biochemistry and Molecular Genetics, The University of Illinois at Chicago, Chicago, Illinois, United States of America.
Li LM; National Center of Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China.; University of the Chinese Academy of Sciences, Beijing, China.
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Źródło:
PloS one [PLoS One] 2023 Oct 10; Vol. 18 (10), pp. e0292579. Date of Electronic Publication: 2023 Oct 10 (Print Publication: 2023).
Typ publikacji:
Observational Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/pathology
Islets of Langerhans*/metabolism
Insulin-Secreting Cells*/metabolism
Rats ; Humans ; Animals ; Rats, Wistar ; Insulin Secretion ; Insulin/genetics ; Insulin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response.
Autorzy:
Lin D; Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No.19 Xiuhua Road, Haikou, 570311, Hainan, China.
Yu J; Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No.19 Xiuhua Road, Haikou, 570311, Hainan, China.
Lin L; Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No.19 Xiuhua Road, Haikou, 570311, Hainan, China.
Ou Q; Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No.19 Xiuhua Road, Haikou, 570311, Hainan, China.
Quan H; Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No.19 Xiuhua Road, Haikou, 570311, Hainan, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 27; Vol. 13 (1), pp. 16173. Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Prediabetic State*
Glucose Intolerance*
Insulin-Secreting Cells*
Pancreatic Neoplasms*
Humans ; Animals ; Mice ; Insulin Secretion ; Reactive Oxygen Species ; Glucose/pharmacology ; Unfolded Protein Response
Czasopismo naukowe
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Tytuł:
Effect of fenofibrate and selective PPARα modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion.
Autorzy:
Kitamura S; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.; Department of Plastic and Reconstructive Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
Murao N; Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.
Yokota S; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Shimizu M; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.; Department of Neurology, Matsumura General Hospital, Iwaki, Japan.
Ono T; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Seino Y; Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.
Suzuki A; Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.
Maejima Y; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Shimomura K; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. .
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Źródło:
BMC research notes [BMC Res Notes] 2023 Sep 11; Vol. 16 (1), pp. 202. Date of Electronic Publication: 2023 Sep 11.
Typ publikacji:
Journal Article
MeSH Terms:
Fenofibrate*
Animals ; Mice ; PPAR alpha ; Ligands ; Insulin Secretion ; Glucose ; KATP Channels ; Adenosine Triphosphate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance.
Autorzy:
González-Domínguez Á; Grupo de Inflamación, Nutrición, Metabolismo y estrés Oxidativo, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), c/Doctor Marañón, 3 - Edificio Andrés Segovia, 11002, Cádiz, Spain.
Belmonte T; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
Domínguez-Riscart J; Grupo de Inflamación, Nutrición, Metabolismo y estrés Oxidativo, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), c/Doctor Marañón, 3 - Edificio Andrés Segovia, 11002, Cádiz, Spain.; Unidad de Endocrinología Pediátrica y Diabetes, Servicio de Pediatría, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Ruiz-Ocaña P; Grupo de Inflamación, Nutrición, Metabolismo y estrés Oxidativo, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), c/Doctor Marañón, 3 - Edificio Andrés Segovia, 11002, Cádiz, Spain.; Unidad de Endocrinología Pediátrica y Diabetes, Servicio de Pediatría, Hospital Universitario de Jerez, Jerez de la Frontera, Spain.
Muela-Zarzuela I; Grupo de Inflamación y Metabolismo Durante el Envejecimiento, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
Saez-Benito A; Servicio de Análisis Clínicos, Hospital Universitario Puerta del Mar, Cádiz, Spain.; Grupo de Diabetes Mellitus - Autoinmunidad y complicaciones crónicas, Implicaciones Patológicas, clínicas y terapéuticas, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
Montañez-Martínez R; Grupo de Daño cerebral Perinatal, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
Mateos RM; Grupo de Inflamación, Nutrición, Metabolismo y estrés Oxidativo, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), c/Doctor Marañón, 3 - Edificio Andrés Segovia, 11002, Cádiz, Spain. .; Departamento de Biomedicina, Facultad de Ciencias, Biotecnología y Salud Pública y Salud Pública, Universidad de Cádiz, Puerto Real, Spain. .
Lechuga-Sancho AM; Grupo de Inflamación, Nutrición, Metabolismo y estrés Oxidativo, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), c/Doctor Marañón, 3 - Edificio Andrés Segovia, 11002, Cádiz, Spain. .; Unidad de Endocrinología Pediátrica y Diabetes, Servicio de Pediatría, Hospital Universitario Puerta del Mar, Cádiz, Spain. .; Departamento Materno Infantil y Radiología, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Aug 20; Vol. 21 (1), pp. 559. Date of Electronic Publication: 2023 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*
Insulin Resistance*
Child ; Humans ; Case-Control Studies ; Inflammasomes ; Inflammation ; Insulin ; Insulin Secretion ; Leukocytes, Mononuclear ; Obesity/complications ; Oxidative Stress ; Uric Acid
Czasopismo naukowe
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Tytuł:
Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin Resistance in Obese Southern Europeans.
Autorzy:
Bailetti D; Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Sentinelli F; Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Prudente S; Research Unit of Metabolic and Cardiovascular Diseases, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Cimini FA; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Barchetta I; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Totaro M; Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Di Costanzo A; Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Barbonetti A; Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Leonetti F; Diabetes Unit, Department of Medical-Surgical Sciences and Biotechnologies, Santa Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Cavallo MG; Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Baroni MG; Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.; Neuroendocrinology and Metabolic Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 22; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 22.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin Resistance*
Insulin Secretion*
Polymorphism, Single Nucleotide*
Carrier Proteins/*genetics
Diabetes Mellitus, Type 2/*epidemiology
GTPase-Activating Proteins/*genetics
Obesity/*physiopathology
RNA-Binding Proteins/*genetics
Adult ; Cohort Studies ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Female ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 20295

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