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Wyszukujesz frazę ""Insulin-Like Growth Factor Binding Protein 5"" wg kryterium: Temat


Tytuł :
Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5.
Autorzy :
Nguyen XX; Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Sanderson M; Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Helke K; Departments of Comparative Medicine and Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Feghali-Bostwick C; Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 30; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Extracellular Matrix/*metabolism
Fibroblasts/*cytology
Fibrosis/*pathology
Insulin-Like Growth Factor Binding Protein 5/*metabolism
Lung/*cytology
Skin/*cytology
Animals ; Antibiotics, Antineoplastic/toxicity ; Bleomycin/toxicity ; Cells, Cultured ; Female ; Fibroblasts/metabolism ; Fibrosis/chemically induced ; Fibrosis/metabolism ; Humans ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Lung/metabolism ; Male ; Mice ; Mice, Transgenic ; Phenotype ; Skin/metabolism
Czasopismo naukowe
Tytuł :
Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.
Autorzy :
Li X; Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.; Key Laboratory of Biotechnology and Biological Resource Utilization in Universities of Shandong and College of Life Science, Dezhou University, Dezhou, China.
Zhou Q; Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Wang S; Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.
Wang P; Department of Outpatient Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Li J; Key Laboratory of Biotechnology and Biological Resource Utilization in Universities of Shandong and College of Life Science, Dezhou University, Dezhou, China.
Xie Z; Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.; Department of Stomatology, Shengli Oilfield Central Hospital, Dongying, Shandong, China.
Liu C; Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.
Wen J; Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.
Wu X; Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Aug 25; Vol. 12 (16), pp. 16621-16646. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides/*pharmacology
Cancer-Associated Fibroblasts/*drug effects
Cell Differentiation/*drug effects
Cell Proliferation/*drug effects
Cellular Senescence/*drug effects
Fibroblasts/*drug effects
Insulin-Like Growth Factor Binding Protein 5/*metabolism
Protein Kinase Inhibitors/*pharmacology
Pyridines/*pharmacology
rho-Associated Kinases/*antagonists & inhibitors
Cancer-Associated Fibroblasts/enzymology ; Cancer-Associated Fibroblasts/pathology ; Cells, Cultured ; Dermis/cytology ; Fibroblasts/enzymology ; Fibroblasts/pathology ; GATA4 Transcription Factor/genetics ; GATA4 Transcription Factor/metabolism ; Humans ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Phenotype ; Signal Transduction ; Time Factors ; Up-Regulation ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease.
Autorzy :
Duan C; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Allard JB; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
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Źródło :
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2020 Mar 03; Vol. 11, pp. 100. Date of Electronic Publication: 2020 Mar 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Disease/*genetics
Insulin-Like Growth Factor Binding Protein 5/*physiology
Animals ; Humans ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X2.
Autorzy :
Niyonsaba F; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan.
Song P; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Yue H; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Sutthammikorn N; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Umehara Y; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Okumura K; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ogawa H; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
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Źródło :
Allergy [Allergy] 2020 Jan; Vol. 75 (1), pp. 203-207. Date of Electronic Publication: 2019 Jul 28.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Degranulation/*immunology
Insulin-Like Growth Factor Binding Protein 5/*immunology
Mast Cells/*immunology
Nerve Tissue Proteins/*immunology
Pore Forming Cytotoxic Proteins/*immunology
Receptors, G-Protein-Coupled/*immunology
Receptors, Neuropeptide/*immunology
Cell Line ; Humans ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Mast Cells/metabolism ; Nerve Tissue Proteins/metabolism ; Pore Forming Cytotoxic Proteins/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Neuropeptide/metabolism
Raport
Tytuł :
Insulin-Like Growth Factor Binding Protein 5-A Probable Target of Kidney Renal Papillary Renal Cell Carcinoma.
Autorzy :
Wang S; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, China.
Hong Q; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, China.
Geng X; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, China.
Chi K; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, China.
Cai G; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, China.
Wu D; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, China.
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Źródło :
BioMed research international [Biomed Res Int] 2019 Nov 11; Vol. 2019, pp. 3210324. Date of Electronic Publication: 2019 Nov 11 (Print Publication: 2019).
Typ publikacji :
Journal Article
MeSH Terms :
Databases, Genetic*
Gene Expression Regulation, Neoplastic*
Carcinoma, Renal Cell/*metabolism
Insulin-Like Growth Factor Binding Protein 5/*biosynthesis
Kidney Neoplasms/*metabolism
Neoplasm Proteins/*biosynthesis
Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Disease-Free Survival ; Humans ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Neoplasm Proteins/genetics ; Survival Rate ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins.
Autorzy :
Bøtkjær JA; Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen University, Copenhagen, DK-2100, Denmark. .
Noer PR; Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, DK-8000, Denmark.
Oxvig C; Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, DK-8000, Denmark.
Yding Andersen C; Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen University, Copenhagen, DK-2100, Denmark.
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Źródło :
Scientific reports [Sci Rep] 2019 Sep 13; Vol. 9 (1), pp. 13231. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Glycoproteins/*metabolism
Insulin-Like Growth Factor Binding Protein 3/*metabolism
Insulin-Like Growth Factor Binding Protein 4/*metabolism
Insulin-Like Growth Factor Binding Protein 5/*metabolism
Intercellular Signaling Peptides and Proteins/*metabolism
Pregnancy-Associated Plasma Protein-A/*genetics
Female ; Glycoproteins/genetics ; HEK293 Cells ; Humans ; Insulin-Like Growth Factor Binding Protein 3/genetics ; Insulin-Like Growth Factor Binding Protein 4/genetics ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Intercellular Signaling Peptides and Proteins/genetics ; Pregnancy ; Pregnancy-Associated Plasma Protein-A/metabolism ; Protein Binding ; Proteolysis
Czasopismo naukowe
Tytuł :
NADPH oxidase-mediated induction of reactive oxygen species and extracellular matrix deposition by insulin-like growth factor binding protein-5.
Autorzy :
Yasuoka H; Department of Internal Medicine, Division of Rheumatology, Fujita Health University School of Medicine , Aichi , Japan.
Garrett SM; Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina , Charleston, South Carolina.
Nguyen XX; Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina , Charleston, South Carolina.
Artlett CM; Drexel University College of Medicine , Philadelphia, Pennsylvania.
Feghali-Bostwick CA; Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina , Charleston, South Carolina.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2019 Apr 01; Vol. 316 (4), pp. L644-L655. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Extracellular Matrix/*metabolism
Insulin-Like Growth Factor Binding Protein 5/*metabolism
Lung/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Cells, Cultured ; Fibroblasts/metabolism ; Humans ; Idiopathic Pulmonary Fibrosis/etiology ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/metabolism ; Insulin-Like Growth Factor Binding Protein 5/antagonists & inhibitors ; Insulin-Like Growth Factor Binding Protein 5/genetics ; MAP Kinase Signaling System ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NADPH Oxidases/metabolism ; Oxidative Stress ; RNA, Small Interfering/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Scleroderma, Systemic/etiology ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/metabolism
Czasopismo naukowe
Tytuł :
Relationships between Breast Feeding and Breast Cancer Subtypes: Lessons Learned from Studies in Humans and in Mice.
Autorzy :
Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York. .
Higgins MJ; Department of Cellular and Molecular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
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Źródło :
Cancer research [Cancer Res] 2020 Nov 15; Vol. 80 (22), pp. 4871-4877. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Breast*/growth & development
Breast*/physiology
Breast Feeding*
Parity*/physiology
Breast Neoplasms/*etiology
African Americans ; Age Factors ; Animals ; Breast Neoplasms/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; DNA Methylation ; Epigenesis, Genetic ; Female ; GATA3 Transcription Factor/metabolism ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Humans ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Menarche ; Mice ; Neoplasms, Radiation-Induced/etiology ; Pregnancy ; Pregnancy-Associated Plasma Protein-A/genetics ; Pregnancy-Associated Plasma Protein-A/metabolism ; Receptor, ErbB-2 ; Receptors, Estrogen ; Receptors, Progesterone ; Risk ; Stem Cells/radiation effects ; Triple Negative Breast Neoplasms/chemistry
Czasopismo naukowe
Tytuł :
Quercetin induces apoptosis in meningioma cells through the miR-197/IGFBP5 cascade.
Autorzy :
Hu SA; Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 4430022, China.
Cheng J; Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Zhao WH; Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 4430022, China.
Zhao HY; Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 4430022, China. Electronic address: .
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2020 Nov; Vol. 80, pp. 103439. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Insulin-Like Growth Factor Binding Protein 5/*genetics
Meningeal Neoplasms/*pathology
Meningioma/*pathology
MicroRNAs/*genetics
Quercetin/*pharmacology
Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Dose-Response Relationship, Drug ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; Meningeal Neoplasms/genetics ; Meningioma/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments.
Autorzy :
Zhang T; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Guo J; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Gu J; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang Z; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang G; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li H; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang J; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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Źródło :
Oncology reports [Oncol Rep] 2019 Jan; Vol. 41 (1), pp. 279-291. Date of Electronic Publication: 2018 Nov 01.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms/*pathology
Insulin-Like Growth Factor Binding Protein 5/*genetics
Liver Neoplasms/*genetics
MicroRNAs/*metabolism
von Willebrand Factor/*genetics
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/genetics ; Computational Biology ; Datasets as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks/genetics ; Humans ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Liver/pathology ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; MicroRNAs/genetics ; Oligonucleotide Array Sequence Analysis ; Protein Interaction Mapping ; Protein Interaction Maps/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Up-Regulation ; von Willebrand Factor/metabolism
Czasopismo naukowe
Tytuł :
IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease.
Autorzy :
Xiao Z; Department of Clinical Laboratory, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China.
Chu Y; Department of Clinical Laboratory, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China.
Qin W; Department of Clinical Laboratory, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117997. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance/*genetics
Insulin-Like Growth Factor Binding Protein 5/*genetics
Lipid Metabolism/*genetics
Non-alcoholic Fatty Liver Disease/*physiopathology
AMP-Activated Protein Kinases/metabolism ; Animals ; Carrier Proteins/genetics ; Diet, High-Fat ; Disease Models, Animal ; Fatty Acids, Nonesterified/administration & dosage ; Gene Expression Regulation ; Hep G2 Cells ; Humans ; Lipogenesis/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/genetics
Czasopismo naukowe
Tytuł :
Ca fish reveals a critical role of IGF signaling in adaptive epithelial growth.
Autorzy :
Liu C; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.; The Key Laboratory of Mariculture, Education Ministry of China and College of Fisheries, Ocean University of China, Qingdao 266003, China.
Xin Y; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Bai Y; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Lewin G; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
He G; The Key Laboratory of Mariculture, Education Ministry of China and College of Fisheries, Ocean University of China, Qingdao 266003, China.; Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China.
Mai K; The Key Laboratory of Mariculture, Education Ministry of China and College of Fisheries, Ocean University of China, Qingdao 266003, China.; Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China.
Duan C; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. .
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Źródło :
Science signaling [Sci Signal] 2018 Sep 18; Vol. 11 (548). Date of Electronic Publication: 2018 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Signal Transduction*
Calcium/*metabolism
Epithelial Cells/*metabolism
Insulin-Like Growth Factor Binding Protein 5/*metabolism
Somatomedins/*metabolism
Zebrafish/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Animals, Genetically Modified ; Cell Line, Tumor ; Cell Proliferation/genetics ; Epithelial Cells/cytology ; Humans ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Mice ; Mutation ; Zebrafish/genetics ; Zebrafish/growth & development ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer.
Autorzy :
Wang W; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore.
Lim KG; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore.
Feng M; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore.
Bao Y; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore.
Lee PL; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore.
Cai Y; School of Pharmacy and Cancer Research Institute, Jinan University, Guangzhou, Guangdong, China.
Chen Y; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore.; The sixth affiliated hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zhang H; School of Medicine, Jinan University, Guangzhou, Guangdong, China.
Marzese D; Department of Translational Molecular Medicine, John Wayne Cancer Institute, Santa Monica, California, USA.
Hoon DSB; Department of Translational Molecular Medicine, John Wayne Cancer Institute, Santa Monica, California, USA.
Yu Q; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore. .; School of Pharmacy and Cancer Research Institute, Jinan University, Guangzhou, Guangdong, China.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer and Stem Cell Biology, Duke-National University of Singapore Medical School, Singapore.
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2018 Sep; Vol. 17 (9), pp. 1973-1983. Date of Electronic Publication: 2018 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Enhancer of Zeste Homolog 2 Protein/*genetics
Indazoles/*pharmacology
Insulin-Like Growth Factor Binding Protein 5/*genetics
Jumonji Domain-Containing Histone Demethylases/*genetics
Sulfonamides/*pharmacology
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Drug Resistance, Neoplasm/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Epigenesis, Genetic ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Kaplan-Meier Estimate ; MCF-7 Cells ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells.
Autorzy :
Rodvold JJ; The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA.
Xian S; Division of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Nussbacher J; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA.
Tsui B; Division of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Cameron Waller T; Division of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Searles SC; The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA.
Lew A; The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA.
Jiang P; Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA.
Babic I; Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA.
Nomura N; Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA.
Lin JH; Department of Pathology, Stanford University, Palo Alto, CA, 94305, USA.
Kesari S; Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA. .
Carter H; Division of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. .
Zanetti M; The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 20; Vol. 10 (1), pp. 8348. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*drug therapy
Endoribonucleases/*metabolism
Glioblastoma/*drug therapy
Protein-Serine-Threonine Kinases/*metabolism
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*antagonists & inhibitors
Thapsigargin/*pharmacology
Adult ; Apoptosis/drug effects ; Brain/pathology ; Brain/surgery ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; Brain Neoplasms/surgery ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Endoplasmic Reticulum Stress/drug effects ; Endoribonucleases/genetics ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Glioblastoma/mortality ; Glioblastoma/surgery ; Humans ; Insulin-Like Growth Factor Binding Protein 3/genetics ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Primary Cell Culture ; Progression-Free Survival ; Protein-Serine-Threonine Kinases/genetics ; RNA-Seq ; Signal Transduction/genetics ; Spheroids, Cellular ; Thapsigargin/analogs & derivatives ; Thapsigargin/therapeutic use ; Tumor Cells, Cultured ; Unfolded Protein Response/drug effects
Czasopismo naukowe
Tytuł :
HASPIN is involved in the progression of gallbladder carcinoma.
Autorzy :
Zhu D; Department of Gynaecology and Obstetrics, Daping Hospital, Army Medical University, China.
Gu X; Department of Gynaecology and Obstetrics, Daping Hospital, Army Medical University, China.
Lin Z; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
Yu D; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
Wang J; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: .
Li L; Department of Gynaecology and Obstetrics, Daping Hospital, Army Medical University, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 May 15; Vol. 390 (2), pp. 111863. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinoma/*genetics
Gallbladder Neoplasms/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
Protein-Serine-Threonine Kinases/*genetics
RNA, Small Interfering/*genetics
Aged ; Animals ; Apoptosis ; Carcinoma/metabolism ; Carcinoma/pathology ; Carcinoma/therapy ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Clone Cells ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Gallbladder Neoplasms/metabolism ; Gallbladder Neoplasms/pathology ; Gallbladder Neoplasms/therapy ; Humans ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Mice, Nude ; Middle Aged ; Protein Array Analysis ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Differential production of insulin-like growth factor-binding proteins in liver fibrosis progression.
Autorzy :
Martínez-Castillo M; Liver, Pancreas and Motility Laboratory (HIPAM), Unit of Experimental Medicine, School of Medicine, National Autonomous University of Mexico (UNAM), General Hospital of Mexico, Mexico City, Mexico.
Rosique-Oramas D; Liver, Pancreas and Motility Laboratory (HIPAM), Unit of Experimental Medicine, School of Medicine, National Autonomous University of Mexico (UNAM), General Hospital of Mexico, Mexico City, Mexico.
Medina-Avila Z; Liver, Pancreas and Motility Laboratory (HIPAM), Unit of Experimental Medicine, School of Medicine, National Autonomous University of Mexico (UNAM), General Hospital of Mexico, Mexico City, Mexico.
Pérez-Hernández JL; General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, México.
Higuera-De la Tijera F; General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, México.
Santana-Vargas D; General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, México.
Montalvo-Jave EE; General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, México.
Sanchez-Avila F; National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, México.
Torre A; National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, México.
Kershenobich D; Liver, Pancreas and Motility Laboratory (HIPAM), Unit of Experimental Medicine, School of Medicine, National Autonomous University of Mexico (UNAM), General Hospital of Mexico, Mexico City, Mexico.; National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, México.
Gutierrez-Reyes G; Liver, Pancreas and Motility Laboratory (HIPAM), Unit of Experimental Medicine, School of Medicine, National Autonomous University of Mexico (UNAM), General Hospital of Mexico, Mexico City, Mexico. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Jun; Vol. 469 (1-2), pp. 65-75. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Hepatitis C, Chronic/*blood
Insulin-Like Growth Factor Binding Proteins/*blood
Liver Cirrhosis/*blood
Liver Cirrhosis/*diagnosis
Adult ; Cross-Sectional Studies ; Female ; Humans ; Insulin-Like Growth Factor Binding Protein 1/blood ; Insulin-Like Growth Factor Binding Protein 2/blood ; Insulin-Like Growth Factor Binding Protein 3/blood ; Insulin-Like Growth Factor Binding Protein 4/blood ; Insulin-Like Growth Factor Binding Protein 5/blood ; Insulin-Like Growth Factor Binding Protein 6/blood ; Liver Cirrhosis/pathology ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Prospective Studies ; ROC Curve
Czasopismo naukowe
Tytuł :
The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition.
Autorzy :
Liu C; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Li S; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.; College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Noer PR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Kjaer-Sorensen K; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Juhl AK; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Goldstein A; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Ke C; College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.
Oxvig C; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Duan C; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
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Źródło :
ELife [Elife] 2020 Apr 16; Vol. 9. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Calcification, Physiologic/*physiology
Epithelial Cells/*metabolism
Insulin-Like Growth Factor Binding Protein 5/*metabolism
Metalloendopeptidases/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Cell Proliferation/physiology ; Zebrafish
Czasopismo naukowe
Tytuł :
Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
Autorzy :
Sun M; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Long J; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Yi Y; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Xia W; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
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Źródło :
Endocrine journal [Endocr J] 2017 Oct 28; Vol. 64 (10), pp. 963-975. Date of Electronic Publication: 2017 Aug 23.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin-Like Growth Factor Binding Protein 5/*metabolism
alpha Karyopherins/*metabolism
beta Karyopherins/*metabolism
Active Transport, Cell Nucleus ; Gene Deletion ; Genes, Reporter ; Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Immunoprecipitation ; Insulin-Like Growth Factor Binding Protein 5/chemistry ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Kinetics ; Microscopy, Confocal ; Microscopy, Fluorescence ; Mutation ; Nuclear Localization Signals/antagonists & inhibitors ; Nuclear Localization Signals/genetics ; Nuclear Localization Signals/metabolism ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Protein Multimerization ; RNA Interference ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Surface Plasmon Resonance ; Two-Hybrid System Techniques ; alpha Karyopherins/antagonists & inhibitors ; alpha Karyopherins/chemistry ; alpha Karyopherins/genetics ; beta Karyopherins/antagonists & inhibitors ; beta Karyopherins/chemistry ; beta Karyopherins/genetics
Czasopismo naukowe
Tytuł :
MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling.
Autorzy :
Pan J; Clinical Medical College, Xi'an Medical University, Xi'an City, Shaanxi Province, China.
Li K; Department of Cardiology, the First Affiliated Hospital of Xi'an Medical University, Xi'an City, Shaanxi Province, China.
Huang W; Clinical Medical College, Xi'an Medical University, Xi'an City, Shaanxi Province, China.
Zhang X; Clinical Medical College, Xi'an Medical University, Xi'an City, Shaanxi Province, China.
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Źródło :
PloS one [PLoS One] 2017 Oct 10; Vol. 12 (10), pp. e0186245. Date of Electronic Publication: 2017 Oct 10 (Print Publication: 2017).
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Insulin-Like Growth Factor Binding Protein 5/*genetics
MicroRNAs/*genetics
Myocytes, Smooth Muscle/*metabolism
STAT3 Transcription Factor/*genetics
TOR Serine-Threonine Kinases/*genetics
Aorta/cytology ; Aorta/drug effects ; Aorta/metabolism ; Base Sequence ; Becaplermin ; Binding Sites ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Computational Biology ; Diffusion Chambers, Culture ; Gene Expression Regulation ; Genes, Reporter ; Humans ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Luciferases/genetics ; Luciferases/metabolism ; MicroRNAs/metabolism ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/drug effects ; Proto-Oncogene Proteins c-sis/pharmacology ; STAT3 Transcription Factor/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.
Autorzy :
Chieosilapatham P; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Niyonsaba F; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan; Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan. Electronic address: .
Kiatsurayanon C; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Okumura K; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ikeda S; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ogawa H; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
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Źródło :
Journal of dermatological science [J Dermatol Sci] 2017 Oct; Vol. 88 (1), pp. 117-125. Date of Electronic Publication: 2017 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antimicrobial Cationic Peptides/*immunology
Insulin-Like Growth Factor Binding Protein 5/*immunology
Keratinocytes/*immunology
Receptors, G-Protein-Coupled/*metabolism
Regeneration/*immunology
Skin Physiological Phenomena/*immunology
Vascular Endothelial Growth Factor A/*metabolism
Wound Healing/*immunology
Antimicrobial Cationic Peptides/metabolism ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Chemokines/metabolism ; Cyclic AMP/metabolism ; Humans ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Interleukin-8/metabolism ; Keratinocytes/metabolism ; Primary Cell Culture ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/immunology ; Signal Transduction/immunology ; Skin/cytology ; Up-Regulation
Czasopismo naukowe

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