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Wyszukujesz frazę ""Integrin beta1"" wg kryterium: Temat


Tytuł :
Analyzing the Integrin Adhesome by In Situ Proximity Ligation Assay.
Autorzy :
Perrino BA; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA. .
Xie Y; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Alexandru C; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2217, pp. 71-81.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Focal Adhesions/*metabolism
Immunohistochemistry/*methods
Integrin alpha Chains/*metabolism
Integrin beta1/*metabolism
Multiprotein Complexes/*metabolism
Oligonucleotides/*metabolism
Actin Cytoskeleton/metabolism ; Actin Cytoskeleton/ultrastructure ; Antibodies/chemistry ; Extracellular Matrix/metabolism ; Extracellular Matrix/ultrastructure ; Focal Adhesions/ultrastructure ; Gastric Mucosa/metabolism ; Gastric Mucosa/ultrastructure ; Humans ; Image Processing, Computer-Assisted ; Integrin alpha Chains/chemistry ; Integrin beta1/chemistry ; Microscopy, Fluorescence ; Molecular Probes/chemistry ; Molecular Probes/metabolism ; Multiprotein Complexes/chemistry ; Muscle, Smooth/metabolism ; Muscle, Smooth/ultrastructure ; Oligonucleotides/chemical synthesis ; Protein Binding
Czasopismo naukowe
Tytuł :
PPM1F controls integrin activity via a conserved phospho-switch.
Autorzy :
Grimm TM; Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.; Konstanz Research School Chemical Biology, Universität Konstanz, Konstanz, Germany.
Dierdorf NI; Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.; Konstanz Research School Chemical Biology, Universität Konstanz, Konstanz, Germany.
Betz K; Konstanz Research School Chemical Biology, Universität Konstanz, Konstanz, Germany.; Lehrstuhl Zelluläre Chemie, Fachbereich Chemie, Universität Konstanz, Konstanz, Germany.
Paone C; Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.; Konstanz Research School Chemical Biology, Universität Konstanz, Konstanz, Germany.
Hauck CR; Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.; Konstanz Research School Chemical Biology, Universität Konstanz, Konstanz, Germany.
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Źródło :
The Journal of cell biology [J Cell Biol] 2020 Dec 07; Vol. 219 (12).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Integrin beta1/*metabolism
Phosphoprotein Phosphatases/*metabolism
Amino Acid Motifs ; Animals ; Cell Line ; Filamins/genetics ; Filamins/metabolism ; Humans ; Integrin beta1/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Phosphoprotein Phosphatases/genetics
Czasopismo naukowe
Tytuł :
In vitro studies using platelet-rich plasma: Minimum reporting requirements.
Autorzy :
Sharun K; Division of Surgery, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Pawde AM; Division of Surgery, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
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Źródło :
Cell biology international [Cell Biol Int] 2020 Dec; Vol. 44 (12), pp. 2380-2382. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Integrin beta1*
Platelet-Rich Plasma*
Actin Cytoskeleton ; Apoptosis ; Gingipain Cysteine Endopeptidases ; Osteoblasts
Czasopismo naukowe
Tytuł :
The β 1 -integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model.
Autorzy :
Kumaravel S; Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, Texas.
Abbey CA; Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, Bryan, Texas.
Bayless KJ; Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, Bryan, Texas.
Chakraborty S; Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, Texas.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Dec 01; Vol. 319 (6), pp. C1045-C1058. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Cells/*metabolism
Extracellular Matrix/*metabolism
Integrin beta1/*metabolism
Lymphangiogenesis/*physiology
Lymphatic Vessels/*cytology
Cell Line ; Cell Movement/physiology ; Cell Proliferation/physiology ; Fibroblast Growth Factor 2/metabolism ; Fibronectins/metabolism ; Hepatocyte Growth Factor/metabolism ; Humans ; Integrin beta1/genetics ; Interleukin-8/metabolism ; Lipopolysaccharides ; Lysophospholipids/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor C/metabolism ; Vascular Endothelial Growth Factor Receptor-3/metabolism
Czasopismo naukowe
Tytuł :
β1 Integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs.
Autorzy :
Guo SS; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany.
Au TYK; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Wynn S; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Aszodi A; Department of General, Trauma and Reconstructive Surgery, Munich University Hospital, Ludwig-Maximilians-University, Fraunhoferstraβe 20, 82152 Planegg-Martinsried, Germany.
Chan D; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Fässler R; Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany.
Cheah KSE; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China .
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Źródło :
Development (Cambridge, England) [Development] 2020 Nov 18; Vol. 147 (22). Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Wnt Signaling Pathway*
Integrin beta1/*metabolism
Intervertebral Disc/*embryology
Notochord/*embryology
Spine/*embryology
Animals ; Integrin beta1/genetics ; Intervertebral Disc/cytology ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Notochord/cytology ; Spine/cytology
Czasopismo naukowe
Tytuł :
Tp0136 targets fibronectin (RGD)/Integrin β1 interactions promoting human microvascular endothelial cell migration.
Autorzy :
Luo X; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China.
Lin SW; Clinical Laboratory, Xiamen Children's Hospital, Children's Hospital of Fudan University Xiamen Branch, Xiamen, 361006, China.
Xu QY; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China.
Ke WJ; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
Gao ZX; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China.
Tong ML; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China; Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, 361004, China.
Liu LL; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China; Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, 361004, China.
Lin LR; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China; Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, 361004, China.
Zhang HL; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China; Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, 361004, China. Electronic address: .
Yang TC; Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China; Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, 361004, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Nov 01; Vol. 396 (1), pp. 112289. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*pharmacology
Cell Movement/*drug effects
Fibronectins/*genetics
Integrin beta1/*genetics
Treponema pallidum/*metabolism
Antibodies, Neutralizing/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Line ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Cloning, Molecular ; Endothelial Cells/metabolism ; Endothelial Cells/microbiology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fibronectins/antagonists & inhibitors ; Fibronectins/metabolism ; Gene Expression ; Gene Expression Regulation ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Integrin beta1/metabolism ; Oligopeptides/pharmacology ; Protein Binding ; Receptors, CCR2/genetics ; Receptors, CCR2/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Signal Transduction ; Treponema pallidum/chemistry
Czasopismo naukowe
Tytuł :
Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.
Autorzy :
Hinger SA; Department of Biological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Abner JJ; Department of Biological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.
Franklin JL; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.
Jeppesen DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.
Coffey RJ; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.; Veterans Affairs Medical Center, Nashville, TN, 37235, USA.; Vanderbilt University, Nashville, TN, 37235, USA.
Patton JG; Department of Biological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 25; Vol. 10 (1), pp. 15804. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Colorectal Neoplasms/*pathology
Exosomes/*metabolism
Extracellular Vesicles/*metabolism
Integrin beta1/*metabolism
Proto-Oncogene Proteins p21(ras)/*metabolism
rab GTP-Binding Proteins/*metabolism
Cell Communication ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Humans ; Integrin beta1/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Tumor Cells, Cultured ; Tumor Microenvironment ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Talin-1 is the principal platelet Rap1 effector of integrin activation.
Autorzy :
Lagarrigue F; Department of Medicine, University of California, San Diego, La Jolla, CA.; Institut de Pharmacologie et de Biologie Structurale (IPBS), Centre National de la Recherche Scientifique (CNRS), Université Paul Sabatier (UPS), Université de Toulouse, Toulouse, France.
Paul DS; UNC Blood Research Center and.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; and.
Gingras AR; Department of Medicine, University of California, San Diego, La Jolla, CA.
Valadez AJ; Department of Medicine, University of California, San Diego, La Jolla, CA.
Sun H; Department of Medicine, University of California, San Diego, La Jolla, CA.
Lin J; Department of Medicine, University of California, San Diego, La Jolla, CA.
Cuevas MN; Department of Medicine, University of California, San Diego, La Jolla, CA.
Ablack JN; Department of Medicine, University of California, San Diego, La Jolla, CA.
Lopez-Ramirez MA; Department of Medicine, University of California, San Diego, La Jolla, CA.; Department of Pharmacology, University of California, San Diego, La Jolla, CA.
Bergmeier W; UNC Blood Research Center and.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; and.
Ginsberg MH; Department of Medicine, University of California, San Diego, La Jolla, CA.
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Źródło :
Blood [Blood] 2020 Sep 03; Vol. 136 (10), pp. 1180-1190.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Point Mutation*
Thrombopoiesis*
Integrin beta1/*metabolism
Integrin beta3/*metabolism
Talin/*physiology
rap GTP-Binding Proteins/*physiology
rap1 GTP-Binding Proteins/*physiology
Animals ; Female ; Integrin beta1/genetics ; Integrin beta3/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Platelet Activation ; Platelet Aggregation ; Protein Domains ; Signal Transduction
Czasopismo naukowe
Tytuł :
β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells.
Autorzy :
Mousavizadeh R; Department of Physical Therapy, Centre for Hip Health and Mobility, University of British Columbia, 2635 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
Hojabrpour P; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Eltit F; Department of Materials Engineering, University of British Columbia, Vancouver, BC, Canada.
McDonald PC; Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
Dedhar S; Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
McCormack RG; Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.
Duronio V; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Jafarnejad SM; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland, UK.
Scott A; Department of Physical Therapy, Centre for Hip Health and Mobility, University of British Columbia, 2635 Laurel Street, Vancouver, BC, V5Z 1M9, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 28; Vol. 10 (1), pp. 12644. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bioartificial Organs*
Mechanotransduction, Cellular*
Collagen/*metabolism
Integrin beta1/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Tendons/*metabolism
Adult ; Biomechanical Phenomena ; Cell Survival ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; Integrin beta1/genetics ; Male ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; Tendons/cytology
Czasopismo naukowe
Tytuł :
EM2D9, A monoclonal antibody against integrin α5β1, has potent antitumor activity on endometrial cancer in vitro and in vivo.
Autorzy :
Xu Y; The Key Laboratory for Bionics Engineering, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, 130021, China.
Li Y; Department of Anesthesiology, Peking University Third Hospital, Beijing, 100083, China.
Pan J; The Key Laboratory for Bionics Engineering, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, 130021, China.
Kang X; Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Zhang X; Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Feng X; Beijing No.4 High School International Campus, Beijing, 100031, China.
Li S; Beijing Jianlan Institute of Medicine, Beijing, 100190, China.
Li C; Beijing Jianlan Institute of Medicine, Beijing, 100190, China.
Zhang J; Baoding First Central Hospital, Baoding, Hebei, 071000, China.
Li C; Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Beijing Jianlan Institute of Medicine, Beijing, 100190, China. Electronic address: .
Wang G; The Key Laboratory for Bionics Engineering, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, 130021, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Jul 28; Vol. 483, pp. 66-74. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Integrin beta1*/metabolism
Antibodies, Monoclonal/*pharmacology
Antineoplastic Agents, Immunological/*pharmacology
Cell Movement/*drug effects
Endometrial Neoplasms/*drug therapy
Integrin alpha5beta1/*antagonists & inhibitors
Integrins/*antagonists & inhibitors
Animals ; Cell Line, Tumor ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/pathology ; Female ; Focal Adhesion Kinase 1/metabolism ; Humans ; Integrin alpha5beta1/metabolism ; Integrins/metabolism ; Mice, Inbred NOD ; Mice, SCID ; Signal Transduction ; Tetraspanin 24/genetics ; Tetraspanin 24/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β 1 -integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding.
Autorzy :
Baltes F; Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53123, Germany.
Caspers J; Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53123, Germany.
Henze S; Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53123, Germany.
Schlesinger M; Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53123, Germany.
Bendas G; Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53123, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 13; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*metabolism
Breast Neoplasms/*metabolism
Collagen Type I/*metabolism
Discoidin Domain Receptor 1/*physiology
Integrin beta1/*physiology
Neoplasm Proteins/*physiology
ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Biological Transport/drug effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Adhesion/drug effects ; Cell Line, Tumor ; Discoidin Domain Receptor 1/antagonists & inhibitors ; Doxorubicin/metabolism ; Doxorubicin/pharmacology ; Drug Resistance, Neoplasm/physiology ; ErbB Receptors/biosynthesis ; ErbB Receptors/genetics ; Focal Adhesion Kinase 1/metabolism ; Gefitinib/pharmacology ; Gefitinib/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Humans ; Indazoles/pharmacology ; Integrin beta1/genetics ; Integrin beta4/biosynthesis ; Integrin beta4/genetics ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology ; MCF-7 Cells ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors ; Mitoxantrone/metabolism ; Mitoxantrone/pharmacology ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/metabolism ; Piperazines/pharmacology ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition.
Autorzy :
Brannon A 3rd; Medical Scientist Training Program, University of Michigan, Ann Arbor, USA.
Drouillard D; Department of Surgery, University of Michigan Cancer Center, University of Michigan, 1500 East Medical Center Drive, Cancer Center Room 6306, Ann Arbor, MI, 48109-0944, USA.
Steele N; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, USA.
Schoettle S; Department of Surgery, University of Michigan Cancer Center, University of Michigan, 1500 East Medical Center Drive, Cancer Center Room 6306, Ann Arbor, MI, 48109-0944, USA.
Abel EV; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, USA.; Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, 14263, USA.
Crawford HC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, USA.
Pasca di Magliano M; Department of Surgery, University of Michigan Cancer Center, University of Michigan, 1500 East Medical Center Drive, Cancer Center Room 6306, Ann Arbor, MI, 48109-0944, USA. .; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, USA. .; Rogel Cancer Center, University of Michigan, Ann Arbor, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 07; Vol. 10 (1), pp. 11133. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Pancreatic Ductal/*drug therapy
Integrin beta1/*metabolism
MAP Kinase Signaling System/*drug effects
Pancreatic Neoplasms/*drug therapy
Animals ; Apoptosis ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Humans ; Integrin beta1/drug effects ; Mice ; Pancreatic Neoplasms/metabolism ; Proto-Oncogene Proteins p21(ras)/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of ITGB1 enhance the anti-tumor effect of cetuximab in colorectal cancer cell.
Autorzy :
Yang X; Department of General Surgery, The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, China.
Wang S
Yu W
Zheng Y
Wu Y
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Jul 02; Vol. 99 (27), pp. e20944.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
Cetuximab/*pharmacology
Colorectal Neoplasms/*drug therapy
Integrin beta1/*drug effects
Antineoplastic Agents, Immunological/therapeutic use ; Cell Line, Tumor/drug effects ; Cell Line, Tumor/metabolism ; Cetuximab/therapeutic use ; Colorectal Neoplasms/pathology ; Humans ; Integrin beta1/metabolism
Czasopismo naukowe
Tytuł :
Circulating Tumor Cell Migration Requires Fibronectin Acting through Integrin B1 or SLUG.
Autorzy :
Huaman J; Department of Biological Sciences, Hunter College of The City University of New York, New York, NY 10065, USA.; Department of Biology, The Graduate Center of The City University of New York, New York, NY 10016, USA.
Ogunwobi OO; Department of Biological Sciences, Hunter College of The City University of New York, New York, NY 10065, USA.; Department of Biology, The Graduate Center of The City University of New York, New York, NY 10016, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
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Źródło :
Cells [Cells] 2020 Jul 01; Vol. 9 (7). Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Fibronectins/*pharmacology
Integrin beta1/*metabolism
Neoplastic Cells, Circulating/*metabolism
Signal Transduction/*genetics
Snail Family Transcription Factors/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Fibronectins/genetics ; Fibronectins/metabolism ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Integrin beta1/genetics ; Mice ; Neoplasm Metastasis/genetics ; RNA, Small Interfering ; Recombinant Proteins ; Snail Family Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Smilax glabra Roxb. Inhibits Collagen Induced Adhesion and Migration of PC3 and LNCaP Prostate Cancer Cells through the Inhibition of Beta 1 Integrin Expression.
Autorzy :
Kwon OY; Department of Nano-Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea.
Ryu S; Department of Nano-Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea.
Choi JK; Department of Nano-Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea.
Lee SH; Department of Nano-Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 30; Vol. 25 (13). Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Collagen/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Integrin beta1/*metabolism
Plant Extracts/*pharmacology
Prostatic Neoplasms/*pathology
Smilax/*chemistry
Apoptosis ; Biomarkers, Tumor/genetics ; Cell Adhesion ; Cell Movement ; Cell Proliferation ; Humans ; Integrin beta1/genetics ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Signal Transduction ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth.
Autorzy :
Howe EN; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. .; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA. .
Burnette MD; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, USA.; Organogenesis, Birmingham, AL, USA.
Justice ME; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Schnepp PM; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.; Department of Urology, University of Michigan Medical School, Ann Arbor, MI, USA.
Hedrick V; Purdue Proteomics Facility, Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, IN, USA.
Clancy JW; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
Guldner IH; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.
Lamere AT; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, USA.; Mathematics Department, Bryant University, Smithfield, RI, USA.
Li J; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, USA.
Aryal UK; Purdue Proteomics Facility, Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, IN, USA.
D'Souza-Schorey C; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.
Zartman JJ; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA.; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, USA.
Zhang S; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. .; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 1234 N. Notre Dame Avenue, South Bend, IN, USA. .; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 15; Vol. 11 (1), pp. 3017. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Neoplasms/*metabolism
Breast Neoplasms/*pathology
Integrin beta1/*metabolism
rab GTP-Binding Proteins/*metabolism
Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/physiopathology ; Brain Neoplasms/secondary ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Proliferation ; Disease Models, Animal ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Female ; Humans ; Integrin beta1/genetics ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis ; Protein Transport ; Signal Transduction ; Tumor Microenvironment ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
MicroRNA-374b mediates the initiation of non-small cell lung cancer by regulating ITGB1 and p53 expressions.
Autorzy :
Zhao M; Department of Respiratory Medicine, The Second People's Hospital of Liaocheng, Linqing, China.
Tong C; Department of Respiratory Medicine, The Second People's Hospital of Liaocheng, Linqing, China.
Hao Z; Department of Respiratory Medicine, The Second People's Hospital of Liaocheng, Linqing, China.
Zhao R; Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Linqing, China.
Wang L; Department of Respiratory Medicine, Weifang People's Hospital, Weifang, China.
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Źródło :
Thoracic cancer [Thorac Cancer] 2020 Jun; Vol. 11 (6), pp. 1670-1678. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carcinoma, Non-Small-Cell Lung/*pathology
Integrin beta1/*metabolism
Lung Neoplasms/*pathology
MicroRNAs/*genetics
Tumor Suppressor Protein p53/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Movement ; Cell Proliferation ; Female ; Follow-Up Studies ; Humans ; Integrin beta1/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Prognosis ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
HLA-B influences integrin beta-1 expression and pancreatic cancer cell migration.
Autorzy :
Sliker BH; Eppley Institute for Research in Cancer and Allied Diseases and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Goetz BT; Eppley Institute for Research in Cancer and Allied Diseases and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Barnes R; Eppley Institute for Research in Cancer and Allied Diseases and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
King H; Eppley Institute for Research in Cancer and Allied Diseases and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Maurer HC; Columbia University Department of Medicine and the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.
Olive KP; Columbia University Department of Medicine and the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.
Solheim JC; Eppley Institute for Research in Cancer and Allied Diseases and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 May 15; Vol. 390 (2), pp. 111960. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Cell Movement/*genetics
HLA-B Antigens/*genetics
Integrin beta1/*genetics
Pancreas/*metabolism
Cell Line, Tumor ; Cell Proliferation ; Focal Adhesion Kinase 1/genetics ; Focal Adhesion Kinase 1/metabolism ; HLA-B Antigens/metabolism ; Humans ; Integrin alpha2/genetics ; Integrin alpha2/metabolism ; Integrin beta1/metabolism ; Organ Specificity ; Pancreas/pathology ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling.
Autorzy :
Yamashiro Y; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan; .
Thang BQ; Department of Cardiovascular Surgery, University of Tsukuba, Ibaraki 305-8575, Japan.
Ramirez K; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan.; Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, Ibaraki 305-8577, Japan.
Shin SJ; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan.; Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
Kohata T; Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Ohata S; Graduate School of Mechanical Systems Engineering, Ibaraki University, Ibaraki 316-8511, Japan.
Nguyen TAV; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan.; Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, Ibaraki 305-8577, Japan.
Ohtsuki S; Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Nagayama K; Graduate School of Mechanical Systems Engineering, Ibaraki University, Ibaraki 316-8511, Japan.
Yanagisawa H; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan; .; Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8577, Japan.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 05; Vol. 117 (18), pp. 9896-9905. Date of Electronic Publication: 2020 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Integrin beta1/*genetics
Thrombospondin 1/*genetics
Transcription Factors/*genetics
Vascular Remodeling/*genetics
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Aorta/growth & development ; Aorta/metabolism ; Carotid Arteries/growth & development ; Carotid Arteries/metabolism ; Cellular Microenvironment/genetics ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Focal Adhesions/genetics ; Humans ; Integrin beta1/metabolism ; Mechanotransduction, Cellular ; Mice ; Neointima/genetics ; Neointima/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Signal Transduction/genetics ; Thrombospondin 1/metabolism ; Transcription Factors/metabolism ; rap GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Integrin1 is required for the renal cystogenesis caused by ciliary defects.
Autorzy :
Yoo M; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Barisoni LMC; Departments of Pathology and Medicine, Duke University, Durham, North Carolina.
Lee K; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Gusella GL; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 May 01; Vol. 318 (5), pp. F1306-F1312. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cilia/*metabolism
Integrin beta1/*metabolism
Kidney/*metabolism
Kidney Diseases, Cystic/*metabolism
Animals ; Aquaporin 2/genetics ; Aquaporin 2/metabolism ; Cilia/pathology ; Cytokines/metabolism ; Disease Models, Animal ; Fibrosis ; Inflammation Mediators/metabolism ; Integrin beta1/genetics ; Kidney/pathology ; Kidney/physiopathology ; Kidney Diseases, Cystic/genetics ; Kidney Diseases, Cystic/pathology ; Kidney Diseases, Cystic/prevention & control ; Macrophages/metabolism ; Macrophages/pathology ; Mice, Knockout ; Signal Transduction ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe

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