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Tytuł :
Opportunities and Challenges in Tunneling Nanotubes Research: How Far from Clinical Application?
Autorzy :
Han X; Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China.
Wang X; Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 25; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Communication/*drug effects
Drug Development/*methods
Intercellular Junctions/*metabolism
Neoplasms/*metabolism
Animals ; Biological Transport, Active/drug effects ; Biological Transport, Active/genetics ; Biological Transport, Active/physiology ; Cell Communication/genetics ; Humans ; Infections/drug therapy ; Infections/metabolism ; Intercellular Junctions/drug effects ; Intercellular Junctions/pathology ; Intercellular Junctions/ultrastructure ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism
Czasopismo naukowe
Tytuł :
PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation.
Autorzy :
Ninomiya K; Laboratory of Molecular and Cellular Biology, Graduate School of Life Sciences, Tohoku University, Aobayama, Sendai, Miyagi 980-8578, Japan.
Ohta K; Laboratory of Molecular and Cellular Biology, Graduate School of Life Sciences, Tohoku University, Aobayama, Sendai, Miyagi 980-8578, Japan.
Yamashita K; Laboratory of Molecular and Cellular Biology, Graduate School of Life Sciences, Tohoku University, Aobayama, Sendai, Miyagi 980-8578, Japan.; Department of Chemistry, Graduate School of Science, Tohoku University, Aobayama, Sendai, Miyagi 980-8578, Japan.
Mizuno K; Laboratory of Molecular and Cellular Biology, Graduate School of Life Sciences, Tohoku University, Aobayama, Sendai, Miyagi 980-8578, Japan .; Institute of Liberal Arts and Sciences, Tohoku University, Kawauchi, Sendai, Miyagi 980-8576, Japan.
Ohashi K; Laboratory of Molecular and Cellular Biology, Graduate School of Life Sciences, Tohoku University, Aobayama, Sendai, Miyagi 980-8578, Japan .; Department of Chemistry, Graduate School of Science, Tohoku University, Aobayama, Sendai, Miyagi 980-8578, Japan.
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Źródło :
Journal of cell science [J Cell Sci] 2021 Jan 27; Vol. 134 (2). Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins*/genetics
Actins*/metabolism
Intercellular Junctions*/metabolism
Cytoskeleton/metabolism ; Epithelial Cells/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Rho Guanine Nucleotide Exchange Factors/genetics ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions.
Autorzy :
Yu HH; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Zallen JA; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Nov 27; Vol. 370 (6520).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Adhesion*
Mechanotransduction, Cellular*
Drosophila Proteins/*metabolism
Intercellular Junctions/*physiology
Protein-Tyrosine Kinases/*metabolism
Actomyosin/physiology ; Animals ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Embryo, Nonmammalian ; Intercellular Junctions/genetics ; Phosphorylation ; Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł :
Elasticity, Stability, and Quasioscillations of Cell-Cell Junctions in Solid Confluent Epithelia.
Autorzy :
Zankoc C; Jožef Stefan Institute, Ljubljana, Slovenia.
Krajnc M; Jožef Stefan Institute, Ljubljana, Slovenia. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2020 Nov 03; Vol. 119 (9), pp. 1706-1711. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actomyosin*
Intercellular Junctions*
Actin Cytoskeleton ; Elasticity ; Epithelium
Czasopismo naukowe
Tytuł :
Cell-cell junctions as sensors and transducers of mechanical forces.
Autorzy :
Angulo-Urarte A; Amsterdam UMC, University of Amsterdam, Location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
van der Wal T; Amsterdam UMC, University of Amsterdam, Location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Huveneers S; Amsterdam UMC, University of Amsterdam, Location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Sep 01; Vol. 1862 (9), pp. 183316. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mechanical Phenomena*
Adherens Junctions/*chemistry
Intercellular Junctions/*chemistry
Membrane Proteins/*chemistry
Adherens Junctions/genetics ; Blood Pressure/genetics ; Cytoskeleton/chemistry ; Desmosomes/chemistry ; Desmosomes/genetics ; Endothelial Cells/chemistry ; Epithelial Cells/chemistry ; Humans ; Intercellular Junctions/genetics ; Membrane Proteins/genetics ; Tight Junctions/chemistry ; Tight Junctions/genetics
Czasopismo naukowe
Tytuł :
Gold nanoparticles disrupt actin organization and pulmonary endothelial barriers.
Autorzy :
Sinclair WE; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA.
Chang HH; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, 61801, USA.
Dan A; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA.
Kenis PJA; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA.; Carl Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, 61801, USA.
Murphy CJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, 61801, USA.
Leckband DE; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA. .; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, 61801, USA. .; Carl Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, 61801, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 07; Vol. 10 (1), pp. 13320. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gold*/adverse effects
Gold*/chemistry
Gold*/pharmacology
Metal Nanoparticles*/adverse effects
Metal Nanoparticles*/chemistry
Actins/*metabolism
Blood-Air Barrier/*metabolism
Endothelial Cells/*metabolism
Intercellular Junctions/*metabolism
Blood-Air Barrier/pathology ; Cells, Cultured ; Endothelial Cells/pathology ; Humans ; Intercellular Junctions/pathology
Czasopismo naukowe
Tytuł :
Conjunction junction, what's the function? CCN proteins as targets in fibrosis and cancers.
Autorzy :
Leask A; School of Dentistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Jun 01; Vol. 318 (6), pp. C1046-C1054. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cell Communication*
Cellular Microenvironment*
Signal Transduction*
CCN Intercellular Signaling Proteins/*metabolism
Extracellular Matrix/*metabolism
Intercellular Junctions/*metabolism
Neoplasms/*metabolism
Animals ; CCN Intercellular Signaling Proteins/genetics ; Extracellular Matrix/genetics ; Extracellular Matrix/pathology ; Fibrosis ; Gene Expression Regulation, Neoplastic ; Humans ; Intercellular Junctions/genetics ; Intercellular Junctions/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1.
Autorzy :
Chai J; Biology Department, Brookhaven National Laboratory, Upton, NY, USA.
Cai Y; Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, NY, USA.
Pang C; Biology Department, Brookhaven National Laboratory, Upton, NY, USA.
Wang L; Laboratory for Biomolecular Structure, Brookhaven National Laboratory, Upton, NY, USA.
McSweeney S; NSLS-II, Brookhaven National Laboratory, Upton, NY, USA.
Shanklin J; Biology Department, Brookhaven National Laboratory, Upton, NY, USA.; Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, NY, USA.
Liu Q; Biology Department, Brookhaven National Laboratory, Upton, NY, USA. .; NSLS-II, Brookhaven National Laboratory, Upton, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 08; Vol. 12 (1), pp. 3433. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Coronavirus Envelope Proteins/*chemistry
Coronavirus Envelope Proteins/*metabolism
Intercellular Junctions/*metabolism
Membrane Proteins/*metabolism
Nucleoside-Phosphate Kinase/*metabolism
Amino Acid Sequence ; Coronavirus Envelope Proteins/ultrastructure ; Cryoelectron Microscopy ; Humans ; Protein Domains ; SARS-CoV-2/physiology ; Structural Homology, Protein ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes.
Autorzy :
Heiden S; Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer Campus 1-A14, 48149, Münster, Germany.
Siwek R; Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer Campus 1-A14, 48149, Münster, Germany.
Lotz ML; Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer Campus 1-A14, 48149, Münster, Germany.
Borkowsky S; Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer Campus 1-A14, 48149, Münster, Germany.
Schröter R; Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer Campus 1-A14, 48149, Münster, Germany.
Nedvetsky P; Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer Campus 1-A14, 48149, Münster, Germany.
Rohlmann A; Institute of Anatomy and Molecular Neurobiology, University of Münster, Vesaliusweg 2-4, 48149, Münster, Germany.
Missler M; Institute of Anatomy and Molecular Neurobiology, University of Münster, Vesaliusweg 2-4, 48149, Münster, Germany.
Krahn MP; Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer Campus 1-A14, 48149, Münster, Germany. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (7), pp. 3657-3672. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Polarity*
Endocytosis*
Drosophila Proteins/*metabolism
Intercellular Junctions/*physiology
Membrane Proteins/*metabolism
Podocytes/*physiology
Animals ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Podocytes/cytology ; Podocytes/metabolism ; Protein Kinase C/genetics ; Protein Kinase C/metabolism
Czasopismo naukowe
Tytuł :
H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells.
Autorzy :
Ruan T; College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC.
Sun J; College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC; Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC.
Liu W; College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC; Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC.
Prinz RA; Department of Surgery, NorthShore University Health System, Evanston, IL 60201, USA.
Peng D; Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PRC; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC.
Liu X; Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PRC; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC.
Xu X; College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC; Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC; Institutes of Agricultural Science and Technology Development, Yangzhou University, Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu Province, PRC. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Jun 30; Vol. 31 (13), pp. 107801.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alveolar Epithelial Cells/*metabolism
Alveolar Epithelial Cells/*microbiology
Influenza A Virus, H1N1 Subtype/*physiology
Intercellular Junctions/*metabolism
Zinc Finger Protein GLI1/*metabolism
A549 Cells ; Alveolar Epithelial Cells/drug effects ; Animals ; Dogs ; Humans ; Influenza A Virus, H1N1 Subtype/drug effects ; Intercellular Junctions/drug effects ; Lung/metabolism ; Madin Darby Canine Kidney Cells ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinases/metabolism ; Models, Biological ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Signal Transduction/drug effects ; Snail Family Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis.
Autorzy :
Li J; Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China.
Xing J
Lu F
Chang W
Liang N
Li J
Wang Y
Li X
Zhao X
Hou R
Man M
Yin G
Li X
Zhang K
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Źródło :
Acta dermato-venereologica [Acta Derm Venereol] 2020 Apr 21; Vol. 100 (8), pp. adv00122. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Glycolysis*
Mesenchymal Stem Cells*
Intercellular Junctions/*metabolism
Keratinocytes/*physiology
Psoriasis/*pathology
Actinin/metabolism ; Adult ; Cell Adhesion Molecules/metabolism ; Cell Differentiation ; Cell Proliferation ; Coculture Techniques ; Female ; Humans ; Intercellular Junctions/pathology ; Male ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells.
Autorzy :
Chioccarelli T; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
Migliaccio M; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
Suglia A; EHESP, Inserm, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, Université de Rennes, 35000 Rennes, France.
Manfrevola F; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
Porreca V; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
Diano N; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
Errico S; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
Fasano S; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
Cobellis G; Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania 'L. Vanvitelli', Via Costantinopoli 16, 80138 Napoli, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 03; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Adipose Tissue/*drug effects
Benzhydryl Compounds/*adverse effects
Benzhydryl Compounds/*metabolism
Endocannabinoids/*metabolism
Epididymis/*drug effects
Estrogens/*metabolism
Germ Cells/*drug effects
Phenols/*adverse effects
Phenols/*metabolism
Adipose Tissue/metabolism ; Animals ; Endocrine System/drug effects ; Endocrine System/metabolism ; Epididymis/metabolism ; Epithelium/drug effects ; Epithelium/metabolism ; Germ Cells/metabolism ; Intercellular Junctions/drug effects ; Intercellular Junctions/metabolism ; Male ; Mice ; Risk Factors ; Testosterone/metabolism
Czasopismo naukowe
Tytuł :
Alteration of cell junctions during viral infection.
Autorzy :
Dong D; Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
Xie W; Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
Liu M; Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
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Źródło :
Thoracic cancer [Thorac Cancer] 2020 Mar; Vol. 11 (3), pp. 519-525. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Intercellular Junctions/*pathology
Virus Diseases/*virology
Viruses/*pathogenicity
Animals ; Humans ; Intercellular Junctions/virology
Czasopismo naukowe
Tytuł :
New insight into podocyte slit diaphragm, a therapeutic target of proteinuria.
Autorzy :
Kawachi H; Department of Cell Biology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan. .
Fukusumi Y; Department of Cell Biology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
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Źródło :
Clinical and experimental nephrology [Clin Exp Nephrol] 2020 Mar; Vol. 24 (3), pp. 193-204. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Intercellular Junctions*
Molecular Targeted Therapy*
Podocytes*
Proteinuria/*therapy
Humans
Czasopismo naukowe
Tytuł :
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Autorzy :
Franke WW; Helmholtz Group for Cell Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. .
Domke LM; Helmholtz Group for Cell Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Dörflinger Y; Helmholtz Group for Cell Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Zimbelmann R; Helmholtz Group for Cell Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
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Źródło :
Cell and tissue research [Cell Tissue Res] 2020 Jan; Vol. 379 (1), pp. 75-92. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelial Cells*/cytology
Intercellular Junctions*/ultrastructure
Seminiferous Tubules/*ultrastructure
Testis/*anatomy & histology
Animals ; Biomarkers/analysis ; Humans ; Immunohistochemistry ; Male ; Mammals/anatomy & histology ; Testis/ultrastructure
Czasopismo naukowe
Tytuł :
Bisphenol S perturbs Sertoli cell junctions in male rats via alterations in cytoskeletal organization mediated by an imbalance between mTORC1 and mTORC2.
Autorzy :
Wu H; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Wei Y; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Zhou Y; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Long C; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Hong Y; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Fu Y; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Zhao T; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Wang J; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Wu Y; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Wu S; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
Shen L; Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China. Electronic address: .
Wei G; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China.
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Mar 25; Vol. 762, pp. 144059. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Testis Barrier*
Spermatogenesis*
Adaptor Proteins, Signal Transducing ; Animals ; Intercellular Junctions ; Male ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2 ; Phenols ; Rats ; Sulfones
Czasopismo naukowe
Tytuł :
Mechanochemical control of epidermal stem cell divisions by B-plexins.
Autorzy :
Jiang C; Institute of Pharmacology, University of Marburg, Marburg, Germany.; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Javed A; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
Kaiser L; Institute of Pharmacology, University of Marburg, Marburg, Germany.
Nava MM; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
Xu R; Institute of Pharmacology, University of Marburg, Marburg, Germany.; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Brandt DT; Institute of Pharmacology, University of Marburg, Marburg, Germany.
Zhao D; Institute of Pharmacology, University of Marburg, Marburg, Germany.
Mayer B; Biochemistry, Faculty of Chemistry, and Center for Synthetic Microbiology (synmikro), University of Marburg, Marburg, Germany.
Fernández-Baldovinos J; Institute of Pharmacology, University of Marburg, Marburg, Germany.
Zhou L; Institute of Pharmacology, University of Marburg, Marburg, Germany.; Department of Diabetes and Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Höß C; Institute of Pharmacology, University of Marburg, Marburg, Germany.
Sawmynaden K; LifeArc, Stevenage, UK.
Oleksy A; LifeArc, Stevenage, UK.
Matthews D; LifeArc, Stevenage, UK.
Weinstein LS; Metabolic Diseases Branch, NIDDK, NIH, Bethesda, USA.
Hahn H; Institute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.
Gröne HJ; Institute of Pharmacology, University of Marburg, Marburg, Germany.
Graumann PL; Biochemistry, Faculty of Chemistry, and Center for Synthetic Microbiology (synmikro), University of Marburg, Marburg, Germany.
Niessen CM; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Offermanns S; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.; Medical Faculty, University of Frankfurt, Frankfurt, Germany.
Wickström SA; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Max-Planck-Institute for Biology of Ageing, Cologne, Germany.
Worzfeld T; Institute of Pharmacology, University of Marburg, Marburg, Germany. .; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 26; Vol. 12 (1), pp. 1308. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Adhesion Molecules/*metabolism
Cell Division/*physiology
Epidermal Cells/*metabolism
Nerve Tissue Proteins/*metabolism
Receptors, Cell Surface/*metabolism
Stem Cells/*metabolism
Animals ; Carcinoma, Basal Cell/pathology ; Carrier Proteins/metabolism ; Cell Adhesion ; Cell Proliferation ; Embryonic Development/physiology ; Epithelial Cells/metabolism ; Epithelium/metabolism ; Female ; Intercellular Junctions ; Keratinocytes ; Mice ; Mitosis ; Morphogenesis ; Organogenesis
Czasopismo naukowe
Tytuł :
Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.
Autorzy :
Sankoda N; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.; Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Tanabe W; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Department of Gastroenterology, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Tanaka A; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Shibata H; Department of Otolaryngology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
Woltjen K; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Hakubi Center for Advanced Research, Kyoto University, Kyoto, 606-8501, Japan.
Chiba T; Department of Gastroenterology, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Haga H; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, 606-8507, Japan.
Sakai Y; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Mandai M; Department of Gynecology and Obstetrics, Kyoto University Hospital, Kyoto, 606-8507, Japan.
Yamamoto T; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; AMED-CREST, AMED 1-7-1 Otemachi, Chiyodaku, Tokyo, 100-0004, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.; Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, 606-8507, Japan.
Yamada Y; Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.; AMED-CREST, AMED 1-7-1 Otemachi, Chiyodaku, Tokyo, 100-0004, Japan.
Uemoto S; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Kawaguchi Y; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 25; Vol. 12 (1), pp. 560. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Epithelial Cells/*metabolism
GATA4 Transcription Factor/*genetics
Intercellular Junctions/*genetics
MAP Kinase Signaling System/*genetics
SOXB1 Transcription Factors/*genetics
Animals ; Cells, Cultured ; Female ; GATA4 Transcription Factor/metabolism ; Gastric Mucosa/metabolism ; Keratin-7/genetics ; Keratin-7/metabolism ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Mice, Transgenic ; SOXB1 Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Interactions of Influenza and SARS-CoV-2 with the Lung Endothelium: Similarities, Differences, and Implications for Therapy.
Autorzy :
Latreille E; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Lee WL; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Keenan Centre for Biomedical Research, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.; Interdepartmental Division of Critical Care and the Department of Medicine, University of Toronto, Toronto, ON M5B 1T8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
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Źródło :
Viruses [Viruses] 2021 Jan 22; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Endothelium/*virology
Influenzavirus A/*pathogenicity
Lung Injury/*pathology
Lung Injury/*virology
SARS-CoV-2/*pathogenicity
Blood Platelets/metabolism ; Cytokines/metabolism ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Endothelium/metabolism ; Endothelium/pathology ; Extracellular Traps/immunology ; Humans ; Intercellular Junctions/pathology ; Lung Injury/therapy
Czasopismo naukowe
Tytuł :
Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway.
Autorzy :
Watanabe M; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Nippon Institute for Biological Science, Ome, Tokyo, Japan.
Arii J; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Takeshima K; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Fukui A; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Shimojima M; Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
Kozuka-Hata H; Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Oyama M; Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Minamitani T; Laboratory of Infectious Diseases and Immunity, National Institutes of Biomedical Innovation, Health, and Nutrition, Ibaraki, Osaka, Japan.
Yasui T; Laboratory of Infectious Diseases and Immunity, National Institutes of Biomedical Innovation, Health, and Nutrition, Ibaraki, Osaka, Japan.
Kubota Y; Division of Cell Signaling and Molecular Medicine, Department of Basic Medical Sciences, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Takekawa M; Division of Cell Signaling and Molecular Medicine, Department of Basic Medical Sciences, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kosugi I; Department of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Maruzuru Y; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Koyanagi N; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kato A; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Mori Y; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Kawaguchi Y; Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan .; Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
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Źródło :
Journal of virology [J Virol] 2021 Jan 13; Vol. 95 (3). Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Communication*
Extracellular Signal-Regulated MAP Kinases/*metabolism
Herpes Simplex/*virology
Herpesvirus 1, Human/*physiology
Mitogen-Activated Protein Kinases/*metabolism
Repressor Proteins/*metabolism
Viral Envelope Proteins/*metabolism
A549 Cells ; Extracellular Signal-Regulated MAP Kinases/genetics ; Herpes Simplex/genetics ; Herpes Simplex/metabolism ; Humans ; Intercellular Junctions ; Mitogen-Activated Protein Kinases/genetics ; Repressor Proteins/genetics ; Viral Envelope Proteins/genetics ; Virus Replication
Czasopismo naukowe

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