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Tytuł:
Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin.
Autorzy:
Perevalova AM; Zelman Institute for the Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk 630090, Russia.; Federal Research Center of Fundamental and Translational Medicine, Timakova Street, 2/12, Novosibirsk 630117, Russia.
Gulyaeva LF; Zelman Institute for the Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk 630090, Russia.; Federal Research Center of Fundamental and Translational Medicine, Timakova Street, 2/12, Novosibirsk 630117, Russia.
Pustylnyak VO; Zelman Institute for the Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk 630090, Russia.; Federal Research Center of Fundamental and Translational Medicine, Timakova Street, 2/12, Novosibirsk 630117, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 10; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Interferon Regulatory Factor-1*/genetics
Interferon Regulatory Factor-1*/metabolism
Neoplasms*/genetics
Neoplasms*/metabolism
Humans ; Carcinogenesis/genetics ; Signal Transduction ; Tumor Microenvironment
Czasopismo naukowe
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Tytuł:
Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
Autorzy:
Yang Z; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Xiang Q; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Nicholas J; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Nov 20; Vol. 19 (11), pp. e1011806. Date of Electronic Publication: 2023 Nov 20 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Herpesvirus 8, Human*/physiology
Interferon Regulatory Factor-1*/metabolism
Humans ; Janus Kinases/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Tumor Suppressor Protein p53/metabolism ; TYK2 Kinase/genetics ; TYK2 Kinase/metabolism ; Host-Pathogen Interactions
Czasopismo naukowe
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Tytuł:
The Role of Interferon Regulatory Factor 1 in Regulating Microglial Activation and Retinal Inflammation.
Autorzy:
Yang X; Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.; Aier Eye Hospital Group, Aier Eye Institute, Changsha 410015, China.
Diaz V; Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
Huang H; Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 24; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Inflammation*/pathology
Interferon Regulatory Factor-1*/genetics
Interferon Regulatory Factor-1*/metabolism
Microglia*/metabolism
Animals ; Humans ; Mice ; Rats ; Lipopolysaccharides ; Retina/pathology
Czasopismo naukowe
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Tytuł:
Multiple Genomic Alterations, Including a Novel AFF4::IRF1 Fusion Gene, in a Treatment-Refractory Blastic Plasmacytoid Dendritic-Cell Neoplasm: A Case Report and Literature Review.
Autorzy:
Sahin Y; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Wang YL; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Molecular Diagnostics Lab, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Pei J; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Molecular Diagnostics Lab, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Mansoor N; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Styler M; Department of Bone Marrow Transplant and Cellular Therapies, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Testa JR; Clinical Cytogenomics Lab, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Nejati R; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 25; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 25.
Typ publikacji:
Review; Case Reports
MeSH Terms:
Hematologic Neoplasms*/drug therapy
Hematologic Neoplasms*/genetics
Myeloproliferative Disorders*
Male ; Humans ; Genomics ; Adaptor Proteins, Signal Transducing ; Death ; Transcriptional Elongation Factors ; Interferon Regulatory Factor-1/genetics
Recenzja
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Tytuł:
Hypoxic lung cancer cell-derived exosomal miR-21 mediates macrophage M2 polarization and promotes cancer cell proliferation through targeting IRF1.
Autorzy:
Jin J; Department of Oncology, Xi'an traditional Chinese Medicine Hospital, Xi'an, 710021, Shanxi, China.
Yu G; Department of Oncology, Xi'an Ninth Hospital, Xi'an, 710054, Shanxi, China. Ping_.
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Źródło:
World journal of surgical oncology [World J Surg Oncol] 2022 Jul 27; Vol. 20 (1), pp. 241. Date of Electronic Publication: 2022 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Exosomes*/genetics
Interferon Regulatory Factor-1*/genetics
Lung Neoplasms*/pathology
Macrophage Activation*
MicroRNAs*/genetics
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Hypoxia ; Macrophages/metabolism ; Male ; Mice ; Mice, Nude ; Tumor Microenvironment
Czasopismo naukowe
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Tytuł:
The Modulation of Interferon Regulatory Factor-1 via Caspase-1-Mediated Alveolar Macrophage Pyroptosis in Ventilator-Induced Lung Injury.
Autorzy:
Dai M; Respiratory Department, Xiangya Hospital, Central South University, China.
Li Q; Central Hospital, Changsha, Hunan Province, China.
Pan P; Respiratory Department, Xiangya Hospital, Central South University, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2022 Apr 15; Vol. 2022, pp. 1002582. Date of Electronic Publication: 2022 Apr 15 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Caspase 1*/genetics
Caspase 1*/metabolism
Interferon Regulatory Factor-1*/biosynthesis
Interferon Regulatory Factor-1*/genetics
Interferon Regulatory Factor-1*/metabolism
Macrophages, Alveolar*/metabolism
Macrophages, Alveolar*/pathology
Macrophages, Alveolar*/physiology
Pyroptosis*/genetics
Pyroptosis*/physiology
Ventilator-Induced Lung Injury*/genetics
Ventilator-Induced Lung Injury*/metabolism
Ventilator-Induced Lung Injury*/physiopathology
Animals ; HMGB1 Protein/metabolism ; Interleukin-18/metabolism ; Interleukin-6/metabolism ; Lung/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
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Tytuł:
IRF1 Inhibits Autophagy-Mediated Proliferation of Colorectal Cancer via Targeting ATG13.
Autorzy:
Yuan L; Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zhang X; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Cheng K; Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Li L; Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Guo Z; Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zeng L; Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
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Źródło:
Cancer investigation [Cancer Invest] 2022 Jan; Vol. 40 (1), pp. 35-45. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy/*drug effects
Autophagy-Related Proteins/*metabolism
Colorectal Neoplasms/*physiopathology
Interferon Regulatory Factor-1/*therapeutic use
Animals ; Cell Proliferation ; Disease Models, Animal ; Humans ; Interferon Regulatory Factor-1/pharmacology ; Mice ; Mice, Nude ; Middle Aged ; Transfection
Czasopismo naukowe
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Tytuł:
ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease.
Autorzy:
Ito M; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA. .; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. .
Ducasa GM; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Molina JD; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Santos JV; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Mallela SK; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Kim JJ; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Ge M; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Mitrofanova A; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Sloan A; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Merscher S; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Mimura I; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Fornoni A; Department of Medicine, Katz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 14; Vol. 13 (1), pp. 9616. Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Podocytes*
Diabetic Nephropathies*/genetics
Diabetes Mellitus*
Humans ; Inflammasomes ; Pyroptosis ; Caspase 1/genetics ; Caspases ; Interferon Regulatory Factor-1/genetics ; ATP Binding Cassette Transporter 1/genetics
Czasopismo naukowe
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Tytuł:
An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?
Autorzy:
Brandt M; New York Genome Center, New York, New York, United States of America.; Department of Systems Biology, Columbia University, New York, New York, United States of America.; Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, New York, United States of America.
Kim-Hellmuth S; New York Genome Center, New York, New York, United States of America.; Department of Systems Biology, Columbia University, New York, New York, United States of America.; Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital LMU Munich, Munich, Germany.
Ziosi M; New York Genome Center, New York, New York, United States of America.
Gokden A; New York Genome Center, New York, New York, United States of America.
Wolman A; New York Genome Center, New York, New York, United States of America.
Lam N; New York Genome Center, New York, New York, United States of America.; Program of Pathobiology and Mechanisms of Disease, Columbia University, New York, New York, United States of America.
Recinos Y; New York Genome Center, New York, New York, United States of America.; Department of Systems Biology, Columbia University, New York, New York, United States of America.; Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, New York, United States of America.
Daniloski Z; New York Genome Center, New York, New York, United States of America.; New York University, Department of Biology, New York, New York, United States of America.
Morris JA; New York Genome Center, New York, New York, United States of America.; New York University, Department of Biology, New York, New York, United States of America.
Hornung V; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Schumacher J; Center for Human Genetics, University Hospital Marburg, Marburg, Germany.
Lappalainen T; New York Genome Center, New York, New York, United States of America.; Department of Systems Biology, Columbia University, New York, New York, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Jul 27; Vol. 17 (7), pp. e1009684. Date of Electronic Publication: 2021 Jul 27 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoimmune Diseases/*genetics
Immunity/*genetics
Interferon Regulatory Factor-1/*genetics
Adult ; Autoimmune Diseases/metabolism ; Chromosome Mapping/methods ; DNA, Antisense/genetics ; Female ; Gene Expression/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation/genetics ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study/methods ; HEK293 Cells ; Humans ; Interferon Regulatory Factor-1/metabolism ; Male ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Regulatory Sequences, Nucleic Acid/genetics ; Risk Factors
Czasopismo naukowe
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Tytuł:
FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
Autorzy:
Wang L; Graduate School, Medical College, Nanchang University, Nanchang, Jiangxi Province, China.; Scientific Research Section, Jiangxi Cancer Hospital, Jiangxi Clinical Research Center for Cancer, Nanchang, Jiangxi Province, China.
Luo P; Department of Breast Surgery, Nanchang Third Hospital, Nanchang, China.
Yang Z; Department of Pharmacy, Songjiang District Central Hospital, Shanghai, China.
Zhong X; Graduate School, Medical College, Nanchang University, Nanchang, Jiangxi Province, China.; Department of Oncology Radiotherapy, Jiangxi Cancer Hospital, Jiangxi Clinical Research Center for Cancer, Nanchang, Jiangxi Province, China.
Ji C; Department of Vascular Interventional Radiology, Songjiang District Central Hospital, Shanghai, China.
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Źródło:
PloS one [PLoS One] 2023 Mar 23; Vol. 18 (3), pp. e0280794. Date of Electronic Publication: 2023 Mar 23 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Repressor Proteins*/genetics
Pancreatic Neoplasms*/genetics
Humans ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Promoter Regions, Genetic ; Carcinogenesis ; Interferon Regulatory Factor-1/genetics ; Interferon Regulatory Factor-1/metabolism ; Pancreatic Neoplasms
Czasopismo naukowe
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Tytuł:
Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1).
Autorzy:
Shi J; Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, People's Republic of China.; Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, People's Republic of China.
Jia X; Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
He Y; Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.
Ma X; Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.
Qi X; Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.
Li W; Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, People's Republic of China.
Gao SJ; Tumor Virology Program, UPMC Hillman Cancer Center, and Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Yan Q; Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, People's Republic of China.
Lu C; Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, People's Republic of China.; Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, People's Republic of China.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Apr 06; Vol. 19 (4), pp. e1011324. Date of Electronic Publication: 2023 Apr 06 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Herpesvirus 8, Human*/genetics
Sirtuins*/metabolism
Antiviral Agents/metabolism ; Immune Evasion ; Interferon Regulatory Factor-1/metabolism ; Interferon Regulatory Factor-3/metabolism ; Lysine/metabolism ; Viral Proteins/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.
Autorzy:
Feng H; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Hebei Province Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, China.
Zhang YB; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
Gui JF; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
Lemon SM; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Yamane D; Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Jan 21; Vol. 17 (1), pp. e1009220. Date of Electronic Publication: 2021 Jan 21 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Communicable Diseases/*immunology
Communicable Diseases/*therapy
Host-Pathogen Interactions/*immunology
Immunity, Innate/*immunology
Interferon Regulatory Factor-1/*metabolism
Animals ; Communicable Diseases/metabolism ; Humans ; Interferon Regulatory Factor-1/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1.
Autorzy:
Chen YC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Lee CP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Hsiao CC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Hsu PY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Wang TY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Wu CC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chao TY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Leung SY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chang YP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Lin MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 14; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 14.
Typ publikacji:
Journal Article
MeSH Terms:
Down-Regulation*
Phagocytosis*
Signal Transduction*
Interferon Regulatory Factor-1/*metabolism
Interleukin-10/*metabolism
MicroRNAs/*biosynthesis
Mycobacterium tuberculosis/*metabolism
Sp1 Transcription Factor/*metabolism
Toll-Like Receptor 4/*metabolism
Transforming Growth Factor beta1/*metabolism
Tuberculosis, Pulmonary/*metabolism
Tumor Necrosis Factor-alpha/*metabolism
Female ; Humans ; Interferon Regulatory Factor-1/genetics ; Interleukin-10/genetics ; Male ; MicroRNAs/genetics ; Sp1 Transcription Factor/genetics ; THP-1 Cells ; Toll-Like Receptor 4/genetics ; Transforming Growth Factor beta1/genetics ; Tuberculosis, Pulmonary/genetics ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular characterization and antiviral effects of canine interferon regulatory factor 1 (CaIRF1).
Autorzy:
Hao X; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Pet Engineering Technology Research Center, Guangzhou, Guangdong, Province, 510642, People's Republic of China.
Chen H; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Pet Engineering Technology Research Center, Guangzhou, Guangdong, Province, 510642, People's Republic of China.
Li Y; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Pet Engineering Technology Research Center, Guangzhou, Guangdong, Province, 510642, People's Republic of China.
Chen B; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Pet Engineering Technology Research Center, Guangzhou, Guangdong, Province, 510642, People's Republic of China.
Liang W; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China.
Xiao X; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong, Province, 510642, People's Republic of China.; Guangdong Provincial Pet Engineering Technology Research Center, Guangzhou, Guangdong, Province, 510642, People's Republic of China.
Zhou P; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China. .; Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong, Province, 510642, People's Republic of China. .; Guangdong Provincial Pet Engineering Technology Research Center, Guangzhou, Guangdong, Province, 510642, People's Republic of China. .
Li S; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, Province, 510642, People's Republic of China. .; Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong, Province, 510642, People's Republic of China. .; Guangdong Provincial Pet Engineering Technology Research Center, Guangzhou, Guangdong, Province, 510642, People's Republic of China. .
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Źródło:
BMC veterinary research [BMC Vet Res] 2022 Dec 16; Vol. 18 (1), pp. 440. Date of Electronic Publication: 2022 Dec 16.
Typ publikacji:
Journal Article
MeSH Terms:
Antiviral Agents*/pharmacology
Interferons*/metabolism
Animals ; Dogs ; Interferon Regulatory Factor-1/genetics ; Interferon Regulatory Factor-1/metabolism ; Interferon-beta/genetics ; Gene Expression Regulation ; Mammals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IRF-1 Inhibits Angiogenic Activity of HPV16 E6 Oncoprotein in Cervical Cancer.
Autorzy:
Rho SB; Division of Translational Science, Research Institute, National Cancer Center, Goyang, Gyeonggido 411-769, Korea.
Lee SH; Department of Life Science, Yong In University, Yongin, Gyeonggido 449-714, Korea.
Byun HJ; Phamaceutical Biochemistry, College of Pharmacy and Integrated Research Institute for Drug, Dongguk University, Goyang 100-715, Korea.
Kim BR; Phamaceutical Biochemistry, College of Pharmacy and Integrated Research Institute for Drug, Dongguk University, Goyang 100-715, Korea.
Lee CH; Phamaceutical Biochemistry, College of Pharmacy and Integrated Research Institute for Drug, Dongguk University, Goyang 100-715, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 15; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 15.
Typ publikacji:
Journal Article
MeSH Terms:
Interferon Regulatory Factor-1/*metabolism
Neovascularization, Pathologic/*metabolism
Oncogene Proteins, Viral/*metabolism
Uterine Cervical Neoplasms/*metabolism
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells/metabolism ; Human papillomavirus 16/pathogenicity ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Interferon Regulatory Factor-1/genetics ; NF-kappa B/metabolism ; Neovascularization, Pathologic/virology ; Oncogene Proteins, Viral/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Binding ; TOR Serine-Threonine Kinases/metabolism ; Uterine Cervical Neoplasms/virology
Czasopismo naukowe
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Tytuł:
Host-Level Susceptibility and IRF1 Expression Influence the Ability of IFN-γ to Inhibit KSHV Infection in B Lymphocytes.
Autorzy:
Alomari N; Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA 92618, USA.
Totonchy J; Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA 92618, USA.
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Źródło:
Viruses [Viruses] 2022 Oct 19; Vol. 14 (10). Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
B-Lymphocytes*/immunology
Herpesviridae Infections*/genetics
Herpesviridae Infections*/immunology
Herpesvirus 8, Human*/genetics
Herpesvirus 8, Human*/immunology
Interferon-gamma*/immunology
Humans ; Acquired Immunodeficiency Syndrome/immunology ; Castleman Disease/immunology ; Cytokines/immunology ; Interferon Regulatory Factor-1/genetics ; Interferon Regulatory Factor-1/immunology ; Sarcoma, Kaposi/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Disease Susceptibility/immunology
Czasopismo naukowe
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Tytuł:
LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells.
Autorzy:
Lin J; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Xie Z; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Zhang Z; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Li M; Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510000, China.
Ye G; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Yu W; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Li J; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Ye F; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Su Z; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Che Y; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Xu P; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Zeng C; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China.
Wang P; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China. .
Wu Y; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China. .
Shen H; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518000, China. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2022 Sep 21; Vol. 29 (1), pp. 73. Date of Electronic Publication: 2022 Sep 21.
Typ publikacji:
Journal Article
MeSH Terms:
Heterogeneous-Nuclear Ribonucleoprotein D*/metabolism
Heterogeneous-Nuclear Ribonucleoprotein D*/pharmacology
Mesenchymal Stem Cells*/metabolism
RNA, Long Noncoding*/metabolism
Animals ; Anti-Inflammatory Agents/pharmacology ; Humans ; Interferon Regulatory Factor-1/metabolism ; Interferon Regulatory Factor-1/pharmacology ; Mice ; Monocyte Chemoattractant Proteins/metabolism ; Monocyte Chemoattractant Proteins/pharmacology ; Monocytes/metabolism
Czasopismo naukowe
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Tytuł:
TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection.
Autorzy:
Sacramento LA; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto.
Benevides L; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto.; Fiocruz-Bi-Institutional Translational Medicine Project, Brazil.
Maruyama SR; Center for Biological and Health Sciences, Federal University of São Carlos, São Carlos, Brazil.
Tavares L; Department of Cellular and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Fukutani KF; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto.
Francozo M; Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research (Twincore), Hannover Medical School (MHH) and Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Sparwasser T; Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research (Twincore), Hannover Medical School (MHH) and Helmholtz Centre for Infection Research (HZI), Hannover, Germany.; Department of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Cunha FQ; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Almeida RP; Center for Biology and Health Sciences, Federal University of Sergipe, Aracaju, SE, Brazil.
da Silva JS; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto.; Fiocruz-Bi-Institutional Translational Medicine Project, Brazil.
Carregaro V; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Mar 25; Vol. 16 (3), pp. e1008435. Date of Electronic Publication: 2020 Mar 25 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interferon Regulatory Factor-1/*immunology
Interferon-beta/*immunology
Leishmania infantum/*immunology
Leishmaniasis, Visceral/*immunology
Th1 Cells/*immunology
Toll-Like Receptor 4/*immunology
Animals ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Interferon Regulatory Factor-1/genetics ; Interferon-beta/genetics ; Leishmaniasis, Visceral/genetics ; Leishmaniasis, Visceral/pathology ; Mice ; Mice, Knockout ; Th1 Cells/pathology ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
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Tytuł:
Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer.
Autorzy:
Jeyakumar T; Department of Biochemistry, McGill University, Montreal, QC, Canada.
Fodil N; Department of Biochemistry, McGill University, Montreal, QC, Canada.
Van Der Kraak L; Department of Biochemistry, McGill University, Montreal, QC, Canada.
Meunier C; Department of Biochemistry, McGill University, Montreal, QC, Canada.
Cayrol R; Département de Pathologie et de Biologie Cellulaire, Université de Montréal, Montreal, QC, Canada.
McGregor K; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Langlais D; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada.
Greenwood CMT; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Department of Oncology, McGill University, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Beauchemin N; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Department of Oncology, McGill University, Montreal, QC, Canada.; Department of Medicine, McGill University, Montreal, QC, Canada.
Gros P; Department of Biochemistry, McGill University, Montreal, QC, Canada. .; Department of Human Genetics, McGill University, Montreal, QC, Canada. .; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2019 Dec 11; Vol. 9 (1), pp. 18897. Date of Electronic Publication: 2019 Dec 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colitis/*metabolism
Colorectal Neoplasms/*metabolism
Interferon Regulatory Factor-1/*metabolism
Animals ; Colitis/complications ; Colitis/genetics ; Colitis/pathology ; Colon/metabolism ; Colon/pathology ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Disease Models, Animal ; Genetic Predisposition to Disease ; Interferon Regulatory Factor-1/genetics ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Mice ; Mice, Knockout
Czasopismo naukowe
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Tytuł:
Single-Cell Transcriptome Analysis Reveals the Importance of IRF1/FSTL1 in Synovial Fibroblast Subsets for the Development of Rheumatoid Arthritis.
Autorzy:
Wang Q; Department of traumatic orthopedics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.; Department of Joint and Sports Medicine, Taian City Central Hospital, Taian City, Shandong, China.
Yu X; Department of nuclear medicine, Taian City Central Hospital, Taian City, Shandong, China.
Gong M; Department of traumatic orthopedics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
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Źródło:
Computational and mathematical methods in medicine [Comput Math Methods Med] 2022 May 05; Vol. 2022, pp. 1169614. Date of Electronic Publication: 2022 May 05 (Print Publication: 2022).
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Arthritis, Rheumatoid*/genetics
Arthritis, Rheumatoid*/metabolism
Follistatin-Related Proteins*/genetics
Follistatin-Related Proteins*/metabolism
Osteoarthritis*/genetics
Osteoarthritis*/metabolism
Fibroblasts ; Gene Expression Profiling ; Humans ; Interferon Regulatory Factor-1/genetics ; Interferon Regulatory Factor-1/metabolism ; Single-Cell Analysis ; Transcriptome
Czasopismo naukowe
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