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Tytuł :
Frontline Science: Estrogen-related receptor γ increases poly(I:C)-mediated type I IFN expression in mouse macrophages.
Autorzy :
Kim KS; National Creative Research Initiatives Center for Nuclear Receptor Signals, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
Kim DK; Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju, Republic of Korea.
Na SY; National Creative Research Initiatives Center for Nuclear Receptor Signals, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
Jung YS; National Creative Research Initiatives Center for Nuclear Receptor Signals, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
Cho SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
Kim J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.
Lee IK; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Kim YH; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Lee CH; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Jeong WI; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Jo EK; Department of Microbiology, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
Choi HS; National Creative Research Initiatives Center for Nuclear Receptor Signals, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 May; Vol. 109 (5), pp. 865-875. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*/drug effects
Interferon Type I/*genetics
Macrophages/*metabolism
Poly I-C/*pharmacology
Receptors, Estrogen/*metabolism
Animals ; DEAD Box Protein 58/metabolism ; Interferon Type I/metabolism ; Interferon-Induced Helicase, IFIH1/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Macrophages/drug effects ; Male ; Mice, Inbred C57BL ; Promoter Regions, Genetic ; Protein Binding/drug effects ; Receptors, Estrogen/genetics ; Signal Transduction/drug effects ; Tamoxifen/analogs & derivatives ; Tamoxifen/pharmacology ; Transcription Factor AP-1/metabolism
Czasopismo naukowe
Tytuł :
Type I Interferon as cardiovascular risk factor in systemic and cutaneous lupus erythematosus: A systematic review.
Autorzy :
Kirchler C; School of Medicine, Sigmund Freud University Vienna, Vienna, Austria. Electronic address: .
Husar-Memmer E; 1st Medical Department, Hanusch Hospital of the Austrian Health Insurance Fund, Vienna, Austria.
Rappersberger K; School of Medicine, Sigmund Freud University Vienna, Vienna, Austria; Department of Dermatology and Venerology, The Rudolfstiftung Hospital, Vienna, Austria.
Thaler K; 1st Medical Department, Hanusch Hospital of the Austrian Health Insurance Fund, Vienna, Austria.
Fritsch-Stork R; School of Medicine, Sigmund Freud University Vienna, Vienna, Austria; 1st Medical Department, Hanusch Hospital of the Austrian Health Insurance Fund, Vienna, Austria; Ludwig Boltzmann Institute of Osteology, Hanusch Hospital and AUVA Trauma Center Meidling, Vienna, Austria.
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Źródło :
Autoimmunity reviews [Autoimmun Rev] 2021 May; Vol. 20 (5), pp. 102794. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Review; Systematic Review
MeSH Terms :
Cardiovascular Diseases*/epidemiology
Cardiovascular Diseases*/etiology
Interferon Type I*
Lupus Erythematosus, Cutaneous*/complications
Lupus Erythematosus, Systemic*/complications
Heart Disease Risk Factors ; Humans ; Risk Factors
Czasopismo naukowe
Tytuł :
Plasmacytoid dendritic cells and type I interferons in flares of systemic lupus erythematosus triggered by COVID-19.
Autorzy :
Nasser N; Department of Dermatology, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, 1107 2020, Lebanon.
Kurban M; Department of Dermatology, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, 1107 2020, Lebanon.
Abbas O; Department of Dermatology, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, 1107 2020, Lebanon. .
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Źródło :
Rheumatology international [Rheumatol Int] 2021 May; Vol. 41 (5), pp. 1019-1020. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Letter; Comment
MeSH Terms :
COVID-19*
Interferon Type I*
Lupus Erythematosus, Systemic*/drug therapy
Dendritic Cells ; Humans ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Positive natural selection in primate genes of the type I interferon response.
Autorzy :
Judd EN; Department of Molecular, Cellular and Developmental Biology; BioFrontiers Institute, University of Colorado Boulder, Boulder, USA.
Gilchrist AR; Department of Molecular, Cellular and Developmental Biology; BioFrontiers Institute, University of Colorado Boulder, Boulder, USA.
Meyerson NR; Department of Molecular, Cellular and Developmental Biology; BioFrontiers Institute, University of Colorado Boulder, Boulder, USA.
Sawyer SL; Department of Molecular, Cellular and Developmental Biology; BioFrontiers Institute, University of Colorado Boulder, Boulder, USA. .
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Źródło :
BMC ecology and evolution [BMC Ecol Evol] 2021 Apr 26; Vol. 21 (1), pp. 65. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon Type I*/genetics
Viruses*
Animals ; Host-Pathogen Interactions ; Primates/genetics ; Selection, Genetic
Czasopismo naukowe
Tytuł :
Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19.
Autorzy :
Zhang J; Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, China.; State Key Laboratory of Microbial Technology, Shandong University, Jinan, China.
Zhao C; Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, China.; State Key Laboratory of Microbial Technology, Shandong University, Jinan, China.; Department of Cell Biology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zhao W; Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, China.; State Key Laboratory of Microbial Technology, Shandong University, Jinan, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 12; Vol. 12, pp. 633769. Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19/*immunology
Interferon Type I/*immunology
SARS-CoV-2/*immunology
COVID-19/drug therapy ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Inflammation ; Interferon Type I/therapeutic use ; Lung/immunology ; Signal Transduction ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
Autorzy :
Winstone H; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Lista MJ; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Reid AC; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Bouton C; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Pickering S; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Galao RP; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Kerridge C; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Doores KJ; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Swanson CM; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Neil SJD; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom .
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Źródło :
Journal of virology [J Virol] 2021 Apr 12; Vol. 95 (9). Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Virus Internalization*
Virus Replication*
Interferon Type I/*metabolism
Membrane Proteins/*metabolism
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*metabolism
A549 Cells ; Humans ; Interferon Type I/genetics ; Membrane Proteins/genetics ; Spike Glycoprotein, Coronavirus/genetics
Czasopismo naukowe
Tytuł :
Epigallocatechin-3-gallate exhibits antiviral effects against the duck Tembusu virus via blocking virus entry and upregulating type I interferons.
Autorzy :
Zhu Y; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Gu X; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Zhang M; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Lv X; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Zhang C; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Li J; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Hu Z; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wu Q; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Zhang R; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wei J; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Huang R; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wang B; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wang Q; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Hefei 230036, China.
Wang G; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Hefei 230036, China. Electronic address: .
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Źródło :
Poultry science [Poult Sci] 2021 Apr; Vol. 100 (4), pp. 100989. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article
MeSH Terms :
Flavivirus*/drug effects
Flavivirus Infections*/drug therapy
Flavivirus Infections*/veterinary
Interferon Type I*/genetics
Poultry Diseases*/drug therapy
Virus Internalization*/drug effects
Catechin/*analogs & derivatives
Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Catechin/pharmacology ; Cell Line ; China ; Cricetinae ; Ducks ; Survival Analysis ; Treatment Outcome ; Up-Regulation/drug effects
SCR Organism :
Tembusu virus
Czasopismo naukowe
Tytuł :
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation.
Autorzy :
Wang W; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China.; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.
Zhou Z; Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking University Genome Editing Research Center, School of Life Sciences, Peking University, Beijing, 100871, China.
Xiao X; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China.; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.
Tian Z; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China.; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.
Dong X; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China.; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.
Wang C; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China.; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.
Li L; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.
Ren L; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China.; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China.
Lei X; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China. .; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China. .; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China. .
Xiang Z; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China. .; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China. .; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China. .
Wang J; NHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China. .; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, PR China. .; Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, PR China. .
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Źródło :
Cellular & molecular immunology [Cell Mol Immunol] 2021 Apr; Vol. 18 (4), pp. 945-953. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*metabolism
Coronavirus RNA-Dependent RNA Polymerase/*metabolism
Interferon Regulatory Factor-3/*metabolism
Interferon Type I/*metabolism
SARS-CoV-2/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Cell Nucleus/metabolism ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/metabolism ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Interferon Regulatory Factor-3/genetics ; Interferon Type I/genetics ; Interferon-Induced Helicase, IFIH1/genetics ; Interferon-Induced Helicase, IFIH1/metabolism ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Mutation ; Phosphorylation ; Promoter Regions, Genetic ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; SARS-CoV-2/enzymology ; Sendai virus/metabolism
Czasopismo naukowe
Tytuł :
Type I and III IFN-mediated antiviral actions counteracted by SARS-CoV-2 proteins and host inherited factors.
Autorzy :
Quarleri J; Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS). Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina. Electronic address: .
Delpino MV; Instituto de Inmunología, Genética y Metabolismo (INIGEM). Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina. Electronic address: .
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Źródło :
Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2021 Apr; Vol. 58, pp. 55-65. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Interferon Type I/*physiology
Interferons/*physiology
SARS-CoV-2/*immunology
Viral Proteins/*physiology
Animals ; Antiviral Agents/metabolism ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/pathology ; Genetic Diseases, Inborn/complications ; Genetic Diseases, Inborn/immunology ; Genetic Predisposition to Disease ; Humans ; Immune Evasion/genetics ; Immune Evasion/immunology ; Immunity, Innate/genetics ; Interferon Type I/antagonists & inhibitors ; Interferons/antagonists & inhibitors ; Pandemics ; SARS-CoV-2/pathogenicity
Czasopismo naukowe
Tytuł :
Type I interferons affect the metabolic fitness of CD8 T cells from patients with systemic lupus erythematosus.
Autorzy :
Buang N; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.
Tapeng L; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.
Gray V; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.
Sardini A; MRC London Institute of Medical Sciences, Imperial College London, London, UK.
Whilding C; MRC London Institute of Medical Sciences, Imperial College London, London, UK.
Lightstone L; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.; Imperial Lupus Centre, Imperial College Healthcare NHS Trust, London, UK.
Cairns TD; Imperial Lupus Centre, Imperial College Healthcare NHS Trust, London, UK.
Pickering MC; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.; Imperial Lupus Centre, Imperial College Healthcare NHS Trust, London, UK.
Behmoaras J; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.
Ling GS; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK. .; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. .
Botto M; Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK. .; Imperial Lupus Centre, Imperial College Healthcare NHS Trust, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 31; Vol. 12 (1), pp. 1980. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Gene Expression Profiling/*methods
Interferon Type I/*immunology
Lupus Erythematosus, Systemic/*immunology
Adult ; Aged ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/metabolism ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Female ; Humans ; Interferon Type I/metabolism ; Interferon Type I/pharmacology ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/metabolism ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/genetics ; Lymphocyte Activation/immunology ; Metabolic Networks and Pathways/genetics ; Middle Aged ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
STING controls nociception via type I interferon signalling in sensory neurons.
Autorzy :
Donnelly CR; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA. .
Jiang C; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Andriessen AS; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Wang K; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Wang Z; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Ding H; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Zhao J; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Luo X; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Lee MS; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Lei YL; Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA.; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
Maixner W; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Ko MC; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.; W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC, USA.
Ji RR; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA. .; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA. .; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA. .
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Źródło :
Nature [Nature] 2021 Mar; Vol. 591 (7849), pp. 275-280. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon Type I/*metabolism
Membrane Proteins/*metabolism
Nociception/*physiology
Pain/*metabolism
Sensory Receptor Cells/*metabolism
Analgesia ; Animals ; Female ; Humans ; Interferon Type I/deficiency ; Interferon Type I/genetics ; Interferon Type I/immunology ; Macaca mulatta ; Male ; Membrane Proteins/agonists ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Mice ; Nociception/drug effects ; Signal Transduction
Czasopismo naukowe
Tytuł :
Nc886, a Novel Suppressor of the Type I Interferon Response Upon Pathogen Intrusion.
Autorzy :
Lee YS; Division of Clinical Cancer Research, Research Institute, National Cancer Center, Goyang 10408, Korea.
Bao X; Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.
Lee HH; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
Jang JJ; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
Saruuldalai E; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
Park G; Division of Clinical Cancer Research, Research Institute, National Cancer Center, Goyang 10408, Korea.
Im WR; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.; Department of Life Science and Multidisciplinary Genome Institute, Hallym University, Chuncheon 24252, Korea.
Park JL; Personalized Genomic Medicine Research Center, KRIBB, Daejeon 34141, Korea.; Department of Functional Genomics, University of Science and Technology, Daejeon 34113, Korea.
Kim SY; Personalized Genomic Medicine Research Center, KRIBB, Daejeon 34141, Korea.; Department of Functional Genomics, University of Science and Technology, Daejeon 34113, Korea.
Shin S; Department of Life Science and Multidisciplinary Genome Institute, Hallym University, Chuncheon 24252, Korea.
Jeon SH; Department of Life Science and Multidisciplinary Genome Institute, Hallym University, Chuncheon 24252, Korea.
Kang S; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
Lee HS; Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Lee JS; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Zhang K; Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.
Park EJ; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
Kim IH; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
Lee YS; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 18; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation/*immunology
Interferon Regulatory Factor-3/*immunology
Interferon Type I/*immunology
RNA, Untranslated/*immunology
Animals ; Cell Line, Tumor ; HCT116 Cells ; HEK293 Cells ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Mice ; NF-kappa B/immunology ; NF-kappa B/metabolism ; Promoter Regions, Genetic/genetics ; RAW 264.7 Cells ; RNA, Untranslated/genetics ; Signal Transduction/immunology ; Transcription Factor AP-1/immunology ; Transcription Factor AP-1/metabolism ; Viruses/immunology ; eIF-2 Kinase/genetics ; eIF-2 Kinase/immunology ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
Revisiting Pleiotropic Effects of Type I Interferons: Rationale for Its Prophylactic and Therapeutic Use Against SARS-CoV-2.
Autorzy :
Garcia-Del-Barco D; Neuroprotection Project, Center for Genetic Engineering and Biotechnology, Pharmaceutical Division, Havana, Cuba.
Risco-Acevedo D; Neuroprotection Project, Center for Genetic Engineering and Biotechnology, Pharmaceutical Division, Havana, Cuba.
Berlanga-Acosta J; Cytoprotection Project, Center for Genetic Engineering and Biotechnology, Pharmaceutical Division, Havana, Cuba.
Martos-Benítez FD; Intensive Care Unit 8B, Hermanos Ameijeiras Hospital, Havana, Cuba.
Guillén-Nieto G; Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Mar 26; Vol. 12, pp. 655528. Date of Electronic Publication: 2021 Mar 26 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19*/drug therapy
COVID-19*/immunology
COVID-19*/pathology
Interferon Type I/*therapeutic use
SARS-CoV-2/*immunology
Angiotensin-Converting Enzyme 2/immunology ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Enzymologic/immunology ; Humans ; Interferon Type I/immunology
Czasopismo naukowe
Tytuł :
Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response.
Autorzy :
Lin JW; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address: .
Tang C; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Wei HC; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Du B; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Chen C; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Wang M; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Zhou Y; Department of Respiratory and Critical Care Medicine, Frontier Science Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Yu MX; Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Cheng L; Microbiomes, Microbes and Informatics Group, Organisms and Environment Division, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK; Department of Computer Science, School of Science, Aalto University, Aalto FI-00076, Finland.
Kuivanen S; University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.
Ogando NS; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Levanov L; University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.
Zhao Y; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Li CL; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zhou R; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Li Z; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zhang Y; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Sun K; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Wang C; Department of Respiratory and Critical Care Medicine, Frontier Science Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Chen L; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Xiao X; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zheng X; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Chen SS; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zhou Z; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Yang R; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zhang D; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Xu M; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Song J; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Wang D; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Li Y; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Lei S; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zeng W; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Yang Q; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
He P; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zhang Y; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Zhou L; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Cao L; Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610041, China.
Luo F; Wuhan Chain Medical Labs, Wuhan, Hubei 430011, China.
Liu H; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Wang L; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Ye F; NHC Key Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhang M; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Li M; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Fan W; Department of Respiratory and Critical Care Medicine, Frontier Science Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Li X; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Li K; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Ke B; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Xu J; Sichuan Center for Disease Control and Prevention, No. 6 Zhongxue Rd, Chengdu 610041, China.
Yang H; Sichuan Center for Disease Control and Prevention, No. 6 Zhongxue Rd, Chengdu 610041, China.
He S; Sichuan Center for Disease Control and Prevention, No. 6 Zhongxue Rd, Chengdu 610041, China.
Pan M; Sichuan Center for Disease Control and Prevention, No. 6 Zhongxue Rd, Chengdu 610041, China.
Yan Y; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Zha Y; Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610041, China.
Jiang L; Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610041, China.
Yu C; Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610041, China.
Liu Y; Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610041, China.
Xu Z; Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610041, China.
Li Q; Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610041, China.
Jiang Y; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Sun J; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong 511430, China.
Hong W; CAS Key Laboratory of Special Pathogens and Biosafety, Centre for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wei H; CAS Key Laboratory of Special Pathogens and Biosafety, Centre for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Lu G; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Vapalahti O; University of Helsinki, Medicum, Department of Virology, Helsinki, Finland; University of Helsinki and Helsinki University Hospital, Department of Virology, Helsinki, Finland; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Luo Y; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Wei Y; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Connor T; Microbiomes, Microbes and Informatics Group, Organisms and Environment Division, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Tan W; NHC Key Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Snijder EJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Smura T; University of Helsinki, Medicum, Department of Virology, Helsinki, Finland; University of Helsinki and Helsinki University Hospital, Department of Virology, Helsinki, Finland. Electronic address: .
Li W; Department of Respiratory and Critical Care Medicine, Frontier Science Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: .
Geng J; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China. Electronic address: .
Ying B; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China. Electronic address: .
Chen L; Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China; Department of Laboratory Medicine and Department of Pediatric Infectious Diseases, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2021 Mar 10; Vol. 29 (3), pp. 489-502.e8. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*immunology
COVID-19/*virology
Interferon Type I/*immunology
SARS-CoV-2/*genetics
SARS-CoV-2/*immunology
Viral Nonstructural Proteins/*genetics
A549 Cells ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Base Sequence ; COVID-19/blood ; Cell Line ; Child ; Child, Preschool ; Chlorocebus aethiops ; Female ; Gene Deletion ; Genomics ; HEK293 Cells ; Humans ; Infant ; Interferon Type I/blood ; Interferon-beta/blood ; Interferon-beta/metabolism ; Male ; Middle Aged ; Molecular Epidemiology ; Reverse Genetics ; Vero Cells ; Viral Nonstructural Proteins/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity.
Autorzy :
Hoagland DA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Møller R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Uhl SA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Oishi K; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Frere J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Golynker I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Horiuchi S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Panis M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Blanco-Melo D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sachs D; Department of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Arkun K; Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA 02111, USA.
Lim JK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
tenOever BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 Mar 09; Vol. 54 (3), pp. 557-570.e5. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Host-Pathogen Interactions*/immunology
COVID-19/*metabolism
COVID-19/*virology
Interferon Type I/*metabolism
SARS-CoV-2/*physiology
Animals ; Biopsy ; COVID-19/genetics ; COVID-19/immunology ; Cricetinae ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Gene Expression Profiling ; Humans ; Immunity, Innate ; Interferon Type I/genetics ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Lung/virology ; Organ Specificity/immunology ; Virulence ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
Modulation of Cardiometabolic Disease Markers by Type I Interferon Inhibition in Systemic Lupus Erythematosus.
Autorzy :
Casey KA; AstraZeneca, Gaithersburg, Maryland.
Smith MA; AstraZeneca, Gaithersburg, Maryland.
Sinibaldi D; AstraZeneca, Gaithersburg, Maryland.
Seto NL; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
Playford MP; National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland.
Wang X; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
Carlucci PM; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
Wang L; AstraZeneca, Gaithersburg, Maryland.
Illei G; AstraZeneca, Gaithersburg, Maryland.
Yu B; AstraZeneca, Gaithersburg, Maryland.
Wang S; AstraZeneca, Gaithersburg, Maryland.
Remaley AT; National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland.
Mehta NN; National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland.
Kaplan MJ; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
White WI; AstraZeneca, Gaithersburg, Maryland.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2021 Mar; Vol. 73 (3), pp. 459-471. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
Atherosclerosis/*metabolism
Extracellular Traps/*immunology
Interferon Type I/*immunology
Interleukin-10/*immunology
Lupus Erythematosus, Systemic/*drug therapy
Tumor Necrosis Factor-alpha/*immunology
Acetylation ; Adolescent ; Adult ; Aged ; Apolipoprotein A-I/metabolism ; Biomarkers ; Cardiometabolic Risk Factors ; Cholesterol/metabolism ; Cholesterol, HDL/metabolism ; Cytokines/immunology ; Female ; Glycoproteins/metabolism ; Humans ; Insulin Resistance ; Interferon Type I/genetics ; Interferon-alpha/immunology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/metabolism ; Male ; Middle Aged ; Transcriptome ; Triglycerides/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Type I interferons in pancreatic cancer and development of new therapeutic approaches.
Autorzy :
Blaauboer A; Department of Surgery, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Sideras K; Department of Surgery, Rotterdam, The Netherlands.
van Eijck CHJ; Department of Surgery, Rotterdam, The Netherlands.
Hofland LJ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: .
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Źródło :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2021 Mar; Vol. 159, pp. 103204. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Interferon Type I*
Pancreatic Neoplasms*/drug therapy
Humans ; Immunotherapy ; Interferons ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Clinical features and expression of type I interferon-inducible genes in systemic lupus erythematosus patients harboring rs1143679 polymorphism in China: a single-center, retrospective study.
Autorzy :
Xu W; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Zhang Y; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Wang X; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Liu P; Department of Pharmacology, School of Basic Medical Science, Nanjing Medical University, Nanjing, 211166, China.
Gao D; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Gu B; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Zhang J; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Li C; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Ren Q; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Yang L; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Yuan H; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Shen M; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
Chen X; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China. .
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Źródło :
Clinical rheumatology [Clin Rheumatol] 2021 Mar; Vol. 40 (3), pp. 1093-1101. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Interferon Type I*/genetics
Lupus Erythematosus, Systemic*/genetics
Case-Control Studies ; China ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Auto-antibodies against type I IFNs are associated with severe COVID-19 pneumonia.
Autorzy :
Zhou W; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People's Republic of China.
Wang W; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People's Republic of China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Feb 26; Vol. 6 (1), pp. 96. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
COVID-19*
Interferon Type I*
Autoantibodies ; Humans ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon.
Autorzy :
Finney LJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Glanville N; Prokarium, London BioScience Innovation Centre, London, United Kingdom.
Farne H; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Aniscenko J; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Fenwick P; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Kemp SV; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton and Harefield NHS Trust, London, United Kingdom.
Trujillo-Torralbo MB; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Loo SL; Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, United Kingdom.
Calderazzo MA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Wedzicha JA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Mallia P; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Bartlett NW; Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, United Kingdom.
Johnston SL; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Singanayagam A; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Feb; Vol. 147 (2), pp. 510-519.e5. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*
SARS-CoV-2*
Adrenal Cortex Hormones/*administration & dosage
Angiotensin-Converting Enzyme 2/*antagonists & inhibitors
Interferon Type I/*antagonists & inhibitors
Pulmonary Disease, Chronic Obstructive/*immunology
Administration, Inhalation ; Aged ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Animals ; Bronchi/cytology ; Cells, Cultured ; Disease Susceptibility ; Down-Regulation/drug effects ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Female ; Humans ; Interferon Type I/immunology ; Lung/drug effects ; Lung/immunology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/genetics ; Receptor, Interferon alpha-beta/genetics ; Serine Endopeptidases/genetics
Czasopismo naukowe

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