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Tytuł :
KAP1-Mediated Epigenetic Suppression in Anti-RNA Viral Responses by Direct Targeting RIG-I and MDA5.
Autorzy :
Li Q; Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; and.
Qin Y; Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; and.
Wang W; Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; and.
Jia M; Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; and.
Zhao W; Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; and .
Zhao C; Department of Cell Biology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Oct 01; Vol. 207 (7), pp. 1903-1910. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Interferon-beta*/genetics
Interferon-beta*/metabolism
RNA*
Animals ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/metabolism ; Epigenesis, Genetic ; Interferon-Induced Helicase, IFIH1/metabolism ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
ACKR2 limits skin fibrosis and hair loss through IFN-β.
Autorzy :
Butenko S; Department of Biology and Human Biology, University of Haifa, Haifa, Israel.
Ben Jashar N; Department of Biology and Human Biology, University of Haifa, Haifa, Israel.
Sheffer T; Department of Biology and Human Biology, University of Haifa, Haifa, Israel.
Sabo E; Institute of Pathology, Carmel Medical Center, Haifa, Israel.
Schif-Zuck S; Department of Biology and Human Biology, University of Haifa, Haifa, Israel.
Ariel A; Department of Biology and Human Biology, University of Haifa, Haifa, Israel.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Oct; Vol. 35 (10), pp. e21917.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alopecia/*metabolism
Fibrosis/*metabolism
Interferon-beta/*metabolism
Receptors, Chemokine/*metabolism
Skin/*metabolism
Alopecia/genetics ; Alopecia/pathology ; Animals ; Collagen/metabolism ; Fibrosis/genetics ; Fibrosis/pathology ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Interferon-beta/deficiency ; Interferon-beta/genetics ; Interleukin-10/metabolism ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Phenotype ; Receptors, Chemokine/deficiency ; Receptors, Chemokine/genetics ; Skin/pathology
Czasopismo naukowe
Tytuł :
Disruption of interferon-β production by the N of atypical porcine pestivirus.
Autorzy :
Mou C; College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.
Pan S; College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.
Wu H; College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.
Chen Z; College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.
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Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 654-665.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon-beta/*biosynthesis
Pestivirus/*genetics
Pestivirus/*immunology
Viral Proteins/*genetics
Viral Proteins/*immunology
Animals ; Cell Line ; Gene Expression ; Genome, Viral ; HEK293 Cells ; Humans ; Immune Evasion ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon-beta/genetics ; Phosphorylation ; Phylogeny ; Signal Transduction ; Swine ; Swine Diseases/virology
Czasopismo naukowe
Tytuł :
SARS-CoV-2 3C-like protease antagonizes interferon-beta production by facilitating the degradation of IRF3.
Autorzy :
Zhang W; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Ma Z; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Wu Y; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Shi X; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Zhang Y; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Zhang M; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhang M; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Wang L; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Liu W; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China. Electronic address: .
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Źródło :
Cytokine [Cytokine] 2021 Dec; Vol. 148, pp. 155697. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Coronavirus 3C Proteases/*metabolism
Interferon Regulatory Factor-3/*metabolism
Interferon-beta/*biosynthesis
DEAD Box Protein 58/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Interferon-beta/genetics ; NF-kappa B/genetics ; Promoter Regions, Genetic/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Immunologic/metabolism ; Response Elements/genetics ; Sendai virus/physiology ; Signal Transduction
Czasopismo naukowe
Tytuł :
MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression.
Autorzy :
Freed SM; Department of Biology, College of Science and Technology, Bellevue University, NE, USA.
Baldi DS; Department of Biology, College of Science and Technology, Bellevue University, NE, USA.
Snow JA; Department of Biology, College of Science and Technology, Bellevue University, NE, USA.
Athen SR; Department of Biology, College of Science and Technology, Bellevue University, NE, USA.
Guinn ZP; Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, USA.
Pinkerton TS; Department of Biology, College of Science and Technology, Bellevue University, NE, USA.
Petro TM; Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, USA.
Moore TC; Department of Biology, College of Science and Technology, Bellevue University, NE, USA.
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Źródło :
FEBS letters [FEBS Lett] 2021 Nov; Vol. 595 (21), pp. 2665-2674. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antiviral Agents*
Extracellular Signal-Regulated MAP Kinases*
Interferon-beta*
Animals ; Mice ; Poly I-C ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon.
Autorzy :
Shemesh M; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Aktepe TE; Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Parkville, Melbourne, Victoria, Australia.
Deerain JM; Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Parkville, Melbourne, Victoria, Australia.
McAuley JL; Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Parkville, Melbourne, Victoria, Australia.
Audsley MD; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria, Australia.
David CT; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria, Australia.
Purcell DFJ; Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Parkville, Melbourne, Victoria, Australia.
Urin V; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Hartmann R; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Moseley GW; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria, Australia.
Mackenzie JM; Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Parkville, Melbourne, Victoria, Australia.
Schreiber G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Harari D; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Aug 26; Vol. 17 (8), pp. e1009800. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon-beta/*metabolism
SARS-CoV-2/*immunology
Viral Proteins/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Vesicular Transport/metabolism ; Animals ; Chlorocebus aethiops ; Eukaryotic Initiation Factor-2/metabolism ; HEK293 Cells ; Humans ; Interferon-beta/genetics ; Interferon-beta/pharmacology ; SARS-CoV-2/drug effects ; STAT1 Transcription Factor/metabolism ; Vero Cells ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist.
Autorzy :
Li A; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
Zhao K; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
Zhang B; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
Hua R; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
Fang Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.; University of Chinese Academy of Sciences, Beijing, China.
Jiang W; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
Zhang J; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong Universitygrid.27255.37, Jinan, China.
Hui L; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
Zheng Y; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
Li Y; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Tongji-Rongcheng Center for Biomedicine, Huazhong University of Science and Technology, Wuhan, China.
Zhu C; Department of Clinical Laboratory, Renmin Hospital of Wuhan Universitygrid.49470.3e, Wuhan, China.
Wang PH; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong Universitygrid.27255.37, Jinan, China.
Peng K; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Xia Y; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan Universitygrid.49470.3e, Wuhan, Hubei, China.
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Źródło :
Journal of virology [J Virol] 2021 Aug 10; Vol. 95 (17), pp. e0074721. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus RNA-Dependent RNA Polymerase*/genetics
Coronavirus RNA-Dependent RNA Polymerase*/metabolism
Interferon-beta*/antagonists & inhibitors
Interferon-beta*/biosynthesis
Interferon-beta*/genetics
Promoter Regions, Genetic*
SARS-CoV-2*/genetics
SARS-CoV-2*/metabolism
HEK293 Cells ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
Induction of IFN-β through TLR-3- and RIG-I-Mediated Signaling Pathways in Canine Respiratory Epithelial Cells Infected with H3N2 Canine Influenza Virus.
Autorzy :
Park WJ; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Han SH; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Kim DH; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Song YJ; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Lee JB; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Park SY; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Song CS; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Lee SW; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Choi IS; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
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Źródło :
Journal of microbiology and biotechnology [J Microbiol Biotechnol] 2021 Jul 28; Vol. 31 (7), pp. 942-948.
Typ publikacji :
Journal Article
MeSH Terms :
DEAD Box Protein 58/*metabolism
Epithelial Cells/*virology
Influenza A Virus, H3N2 Subtype/*physiology
Interferon-beta/*metabolism
Toll-Like Receptor 3/*metabolism
Animals ; Cell Line ; DEAD Box Protein 58/genetics ; Dogs ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Interferon Regulatory Factor-3/metabolism ; Interferon-beta/genetics ; Interferon-beta/pharmacology ; Myxovirus Resistance Proteins/metabolism ; RNA, Small Interfering/pharmacology ; Respiratory Mucosa/cytology ; Signal Transduction ; Toll-Like Receptor 3/genetics ; Up-Regulation/genetics ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Role of the Chaperone Protein 14-3-3ε in the Regulation of Influenza A Virus-Activated Beta Interferon.
Autorzy :
Tam EH; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Liu YC; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Woung CH; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Liu HM; Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wu GH; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Wu CC; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.; Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Kuo RL; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan.
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Źródło :
Journal of virology [J Virol] 2021 Sep 27; Vol. 95 (20), pp. e0023121. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
14-3-3 Proteins/*immunology
Influenza, Human/*immunology
Interferon-beta/*metabolism
14-3-3 Proteins/metabolism ; Cell Line, Tumor ; DEAD Box Protein 58/metabolism ; Host-Pathogen Interactions ; Humans ; Immunity, Innate/immunology ; Influenza A virus/metabolism ; Influenza, Human/metabolism ; Interferon Regulatory Factor-3/metabolism ; Interferon Type I/metabolism ; Interferon-beta/physiology ; Promoter Regions, Genetic/genetics ; Protein Processing, Post-Translational ; RNA, Viral/genetics ; Receptors, Immunologic/metabolism ; Viral Nonstructural Proteins/immunology ; Viral Nonstructural Proteins/metabolism ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Epigenetic and transcriptional control of interferon-β.
Autorzy :
Daman AW; Department of Pathology, Weill Cornell Medicine, New York, NY.
Josefowicz SZ; Department of Pathology, Weill Cornell Medicine, New York, NY.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Sep 06; Vol. 218 (9). Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Gene Expression Regulation*
Host-Pathogen Interactions/*physiology
Interferon-beta/*genetics
CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; DNA Methylation ; Enhancer Elements, Genetic ; Host-Pathogen Interactions/genetics ; Humans ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Interferon-beta/metabolism ; Promoter Regions, Genetic ; SARS-CoV-2/pathogenicity ; Transcription, Genetic ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Hepatitis C Virus Evades Interferon Signaling by Suppressing Long Noncoding RNA Linc-Pint Involving C/EBP-β.
Autorzy :
Khatun M; Department of Pathology, Saint Louis Universitygrid.262962.b, Saint Louis, Missouri, USA.
Zhang J; Department of Pharmacology and Physiology, Saint Louis Universitygrid.262962.b, Saint Louis, Missouri, USA.
Ray R; Department of Internal Medicine, Saint Louis Universitygrid.262962.b, Saint Louis, Missouri, USA.
Ray RB; Department of Pathology, Saint Louis Universitygrid.262962.b, Saint Louis, Missouri, USA.
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Źródło :
Journal of virology [J Virol] 2021 Aug 10; Vol. 95 (17), pp. e0095221. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CCAAT-Enhancer-Binding Protein-beta/*metabolism
Hepacivirus/*immunology
Hepatitis C/*immunology
Immunity, Innate/*immunology
Interferon-alpha/*metabolism
Interferon-beta/*metabolism
RNA, Long Noncoding/*antagonists & inhibitors
CCAAT-Enhancer-Binding Protein-beta/genetics ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Hepatitis C/metabolism ; Hepatitis C/virology ; Hepatocytes/immunology ; Hepatocytes/metabolism ; Hepatocytes/virology ; Humans ; Interferon-alpha/genetics ; Interferon-beta/genetics ; RNA, Long Noncoding/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Porcine deltacoronavirus nsp10 antagonizes interferon-β production independently of its zinc finger domains.
Autorzy :
Fang P; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Hong Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Xia S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Zhang J; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Ren J; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Zhou Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Fang L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Xiao S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
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Źródło :
Virology [Virology] 2021 Jul; Vol. 559, pp. 46-56. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deltacoronavirus/*metabolism
Interferon-beta/*antagonists & inhibitors
Viral Nonstructural Proteins/*metabolism
Animals ; Cell Line ; Host-Pathogen Interactions ; Humans ; Interferon Regulatory Factor-3/metabolism ; Interferon-beta/metabolism ; Mutation ; Sendai virus/metabolism ; Signal Transduction ; Swine ; Transcription Factor RelA/metabolism ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Zinc Fingers
Czasopismo naukowe
Tytuł :
Statins attenuate antiviral IFN-β and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages.
Autorzy :
Koike A; Department of Pathobiochemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Tsujinaka K; Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Fujimori K; Department of Pathobiochemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
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Źródło :
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (14), pp. 4249-4266. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation/*drug effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
Hyperlipidemias/*drug therapy
Interferon Regulatory Factors/*metabolism
Interferon-beta/*metabolism
Macrophages/*drug effects
Poly I-C/*toxicity
Animals ; Hyperlipidemias/chemically induced ; Hyperlipidemias/metabolism ; Hyperlipidemias/pathology ; Interferon Inducers/toxicity ; Interferon Regulatory Factor-3/antagonists & inhibitors ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon Regulatory Factors/genetics ; Interferon-beta/genetics ; Janus Kinases/antagonists & inhibitors ; Janus Kinases/genetics ; Janus Kinases/metabolism ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred C57BL ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
INFβ treatment affects global DNA methylation in monocytes of patients with multiple sclerosis.
Autorzy :
Diniz SN; Universidade Anhanguera de São Paulo, UNIAN, Programa de Pós-Graduação em Farmácia e Biotecnologia e Inovação em Saúde, Rua Raimundo Pereira de Magalhães, 3305, Pirituba, Zip Code: 05145-200 São Paulo, SP, Brazil. Electronic address: .
da Silva CF; Universidade Anhanguera de São Paulo, UNIAN, Programa de Pós-Graduação em Biotecnologia e Inovação em Saúde, Rua Raimundo Pereira de Magalhães, 3305, Pirituba, Zip Code: 05145-200 São Paulo, SP, Brazil. Electronic address: .
de Almeida IT; Universidade Federal de São Paulo, UNIFESP, Disciplina de Neurologia, Rua Pedro de Toledo, 650, Vila Clementino, Zip Code: 04039-002 São Paulo, SP, Brazil.
da Silva Costa FE; Universidade Anhanguera de São Paulo, UNIAN, Programa de Pós-Graduação em Biotecnologia e Inovação em Saúde, Rua Raimundo Pereira de Magalhães, 3305, Centro Pirituba, Zip Code: 05145-200 São Paulo, SP, Brazil.
de Oliveira EML; Universidade Federal de São Paulo, UNIFESP, Disciplina de Neurologia, Rua Pedro de Toledo, 650, Vila Cldementino, Zip Code: 04039-002 São Paulo, SP, Brazil. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2021 Jun 15; Vol. 355, pp. 577563. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation/*drug effects
Immunologic Factors/*therapeutic use
Interferon-beta/*therapeutic use
Monocytes/*drug effects
Multiple Sclerosis, Relapsing-Remitting/*diagnosis
Multiple Sclerosis, Relapsing-Remitting/*drug therapy
Adult ; Cross-Sectional Studies ; DNA Methylation/physiology ; Female ; Humans ; Immunologic Factors/pharmacology ; Interferon-beta/pharmacology ; Male ; Middle Aged ; Monocytes/immunology ; Multiple Sclerosis, Relapsing-Remitting/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta.
Autorzy :
Rashid F; Dermatology Hospital, Southern Medical University, Guangzhou, China. Electronic address: .
Dzakah EE; Dermatology Hospital, Southern Medical University, Guangzhou, China; Department of Molecular Biology and Biotechnology, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana. Electronic address: .
Wang H; Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: .
Tang S; Dermatology Hospital, Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Apr 15; Vol. 296, pp. 198350. Date of Electronic Publication: 2021 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Immune Evasion*
Endoplasmic Reticulum Stress/*physiology
Interferon-beta/*antagonists & inhibitors
Viral Proteins/*physiology
Activating Transcription Factor 6/physiology ; Endoribonucleases/physiology ; HEK293 Cells ; Humans ; Interferon-beta/biosynthesis ; Protein-Serine-Threonine Kinases/physiology ; Sequence Alignment ; Signal Transduction/physiology ; Unfolded Protein Response ; Viral Proteins/chemistry ; X-Box Binding Protein 1/physiology ; eIF-2 Kinase/physiology
Czasopismo naukowe
Tytuł :
Agent-based modeling reveals benefits of heterogeneous and stochastic cell populations during cGAS-mediated IFNβ production.
Autorzy :
Gregg RW; Department of Chemical and Petroleum Engineering, 15260, Pittsburgh, PA 15260, USA.
Shabnam F; Department of Chemical and Petroleum Engineering, 15260, Pittsburgh, PA 15260, USA.
Shoemaker JE; Department of Chemical and Petroleum Engineering, 15260, Pittsburgh, PA 15260, USA.; McGowan Institute for Regenerative Medicine, 15219, Pittsburgh, PA 15260, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2021 Jun 16; Vol. 37 (10), pp. 1428-1434.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Interferon-beta*/genetics
Nucleotidyltransferases*/metabolism
Epithelial Cells ; Humans ; Signal Transduction ; Systems Analysis
Czasopismo naukowe
Tytuł :
IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells.
Autorzy :
Rasouli J; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Casella G; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Ishikawa LLW; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Thome R; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Boehm A; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Ertel A; Sidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States.
Melo-Silva CR; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, United States.
Mari ER; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Porazzi P; Sidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States.
Zhang W; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Xiao D; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Sigal LJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, United States.
Fortina P; Sidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Translation and Precision Medicine, Sapienza University, Rome, Italy.
Zhang GX; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Rostami A; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Ciric B; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jun 04; Vol. 12, pp. 679498. Date of Electronic Publication: 2021 Jun 04 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Autoimmunity*/drug effects
Cell Communication*/genetics
Cell Communication*/immunology
Interferon-beta/*metabolism
Monocytes/*immunology
Monocytes/*metabolism
T-Lymphocytes, Helper-Inducer/*immunology
T-Lymphocytes, Helper-Inducer/*metabolism
Animals ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Disease Susceptibility/immunology ; Encephalomyelitis, Autoimmune, Experimental/etiology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Granulocyte-Macrophage Colony-Stimulating Factor/biosynthesis ; Interferon-beta/pharmacology ; Mice ; Mice, Knockout ; Monocytes/drug effects ; T-Lymphocytes, Helper-Inducer/drug effects
Czasopismo naukowe
Tytuł :
IFN-β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1.
Autorzy :
Tresse E; Faculty of Health and Medical Sciences, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Riera-Ponsati L; Faculty of Health and Medical Sciences, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Jaberi E; Faculty of Health and Medical Sciences, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Sew WQG; Faculty of Health and Medical Sciences, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Ruscher K; Laboratory for Experimental Brain Research and LUBIN Lab - Lunds Laboratorium för Neurokirurgisk Hjärnskadeforskning, Division of Neurosurgery, Department of Clinical Sciences, University of Lund, Lund, Sweden.
Issazadeh-Navikas S; Faculty of Health and Medical Sciences, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
The EMBO journal [EMBO J] 2021 Jun 01; Vol. 40 (11), pp. e106868. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Dynamics*
Interferon-beta/*metabolism
Parkinson Disease/*metabolism
Animals ; Cell Line ; Cell Line, Tumor ; Dynamins/metabolism ; Formins/metabolism ; Interferon-beta/genetics ; Mice ; Mitochondria/metabolism ; Neurons/metabolism ; Phosphoprotein Phosphatases/metabolism ; STAT5 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
IFN-β, but not IFN-α, is Responsible for the Pro-Bacterial Effect of Type I Interferon.
Autorzy :
Shaabani N; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA, .
Vartabedian VF; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Nguyen N; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Honke N; Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany.
Huang Z; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Teijaro JR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA, .
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2021 May 14; Vol. 55 (3), pp. 256-264.
Typ publikacji :
Journal Article
MeSH Terms :
Interferon-alpha/*immunology
Interferon-beta/*immunology
Listeria monocytogenes/*immunology
Listeriosis/*immunology
Animals ; Female ; Interferon-alpha/genetics ; Interferon-beta/genetics ; Listeriosis/genetics ; Male ; Mice ; Mice, Knockout ; Receptor, Interferon alpha-beta/deficiency ; Receptor, Interferon alpha-beta/immunology
Czasopismo naukowe
Tytuł :
Rutin, α-tocopherol, and l-ascorbic acid up-regulate type I interferon-regulated gene and type I and II interferon expressions and reduce inflammatory cytokine expressions in monocyte-derived macrophages infected with highly pathogenic porcine reproductive and respiratory syndrome virus.
Autorzy :
Suebsaard P; Research Laboratory for Immunity Enhancement in Humans and Domestic Animals, Program of Biotechnology, Faculty of Science, Maejo University, Chiang Mai, 50290, Thailand.
Charerntantanakul W; Research Laboratory for Immunity Enhancement in Humans and Domestic Animals, Program of Biotechnology, Faculty of Science, Maejo University, Chiang Mai, 50290, Thailand. Electronic address: .
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Źródło :
Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2021 May; Vol. 235, pp. 110231. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cytokines/*genetics
Interferon Type I/*genetics
Interferon-beta/*genetics
Macrophages/*drug effects
Macrophages/*virology
Porcine respiratory and reproductive syndrome virus/*drug effects
Porcine respiratory and reproductive syndrome virus/*immunology
Animals ; Ascorbic Acid/pharmacology ; Cell Line ; Cytokines/antagonists & inhibitors ; Cytokines/immunology ; Immunity, Innate/drug effects ; Interferon Type I/immunology ; Interferon-beta/immunology ; Macrophages/immunology ; Porcine respiratory and reproductive syndrome virus/pathogenicity ; Rutin/pharmacology ; Swine ; alpha-Tocopherol/pharmacology
Czasopismo naukowe

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