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Tytuł :
Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection.
Autorzy :
Stolzer I; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität (FAU), Erlangen, Germany.
Ruder B; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität (FAU), Erlangen, Germany.
Neurath MF; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität (FAU), Erlangen, Germany; Deutsches Zentrum Immuntherapie DZI, Friedrich-Alexander-Universität (FAU), Erlangen, Nürnberg, Germany.
Günther C; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität (FAU), Erlangen, Germany. Electronic address: .
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Źródło :
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2021 Apr; Vol. 311 (3), pp. 151491. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Interferons*
Signal Transduction*
Cell Death ; Cytokines ; Humans ; Immunity, Innate ; Inflammation
Czasopismo naukowe
Tytuł :
Interferon-based therapies in COVID-19.
Autorzy :
Kow CS; School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia. Electronic address: .
Hasan SS; School of Applied Sciences, University of Huddersfield, Huddersfield, United Kingdom; School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, Australia.
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 Apr; Vol. 93, pp. 107415. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Letter
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Interferons/*therapeutic use
Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacokinetics ; Biological Availability ; Humans ; Interferons/administration & dosage ; Interferons/pharmacokinetics
Opinia redakcyjna
Tytuł :
Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes.
Autorzy :
Feng E; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Balint E; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Poznanski SM; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Ashkar AA; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Loeb M; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
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Źródło :
Cells [Cells] 2021 Mar 23; Vol. 10 (3). Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adaptive Immunity*
Immunity, Innate*
Aging/*immunology
COVID-19/*immunology
Interferons/*physiology
SARS-CoV-2/*immunology
Virus Replication/*immunology
Aged ; COVID-19/drug therapy ; COVID-19/virology ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Interferon Type I/immunology ; Interferon Type I/therapeutic use ; Interferon-gamma/immunology ; Interferon-gamma/therapeutic use ; Interferons/immunology ; Interferons/therapeutic use
Czasopismo naukowe
Tytuł :
Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling.
Autorzy :
Lunova M; Institute for Clinical & Experimental Medicine (IKEM), 14021 Prague, Czech Republic.
Kubovciak J; Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Smolková B; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Uzhytchak M; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Michalova K; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine of Charles University, 12808 Prague, Czech Republic.
Dejneka A; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Strnad P; Department of Internal Medicine III, University Hospital RWTH (Rheinisch-Westfälisch Technische Hochschule) Aachen, 52062 Aachen, Germany.
Lunov O; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Jirsa M; Institute for Clinical & Experimental Medicine (IKEM), 14021 Prague, Czech Republic.; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine of Charles University, 12808 Prague, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 04; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatocytes/*immunology
Hepatocytes/*metabolism
Interferons/*genetics
Interferons/*metabolism
Interleukins/*genetics
Interleukins/*metabolism
Cell Line ; Gene Expression ; Gene Knockout Techniques ; Hep G2 Cells ; Humans ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Interferons/deficiency ; Interleukin-10 Receptor beta Subunit/deficiency ; Interleukin-10 Receptor beta Subunit/genetics ; Interleukin-10 Receptor beta Subunit/metabolism ; Interleukins/deficiency ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Interferon/deficiency ; Receptors, Interferon/genetics ; Receptors, Interferon/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Signal Transduction ; Transfection
Czasopismo naukowe
Tytuł :
Global absence and targeting of protective immune states in severe COVID-19.
Autorzy :
Combes AJ; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. .; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA. .; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA. .
Courau T; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Kuhn NF; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.
Hu KH; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.
Ray A; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.
Chen WS; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.
Chew NW; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Cleary SJ; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Kushnoor D; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Reeder GC; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Shen A; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Tsui J; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Hiam-Galvez KJ; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Otolaryngology, University of California San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Muñoz-Sandoval P; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.; Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA, USA.
Zhu WS; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.; Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA, USA.
Lee DS; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Sun Y; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
You R; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.
Magnen M; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Rodriguez L; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Otolaryngology, University of California San Francisco, San Francisco, CA, USA.
Im KW; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Serwas NK; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.
Leligdowicz A; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Zamecnik CR; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Loudermilk RP; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Wilson MR; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Ye CJ; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Fragiadakis GK; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Looney MR; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Chan V; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.
Ward A; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Carrillo S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Matthay M; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Erle DJ; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Woodruff PG; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Langelier C; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Kangelaris K; Division of Hospital Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Hendrickson CM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Calfee C; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Rao AA; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. .; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA. .; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA. .
Krummel MF; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. .; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA. .
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Corporate Authors :
UCSF COMET Consortium
Źródło :
Nature [Nature] 2021 Mar; Vol. 591 (7848), pp. 124-130. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*immunology
COVID-19/*immunology
COVID-19/*physiopathology
Interferons/*antagonists & inhibitors
Interferons/*immunology
SARS-CoV-2/*immunology
SARS-CoV-2/*pathogenicity
Antibodies, Viral/blood ; Antibody Formation ; Base Sequence ; COVID-19/blood ; COVID-19/virology ; Female ; Humans ; Immunoglobulin G/immunology ; Interferons/metabolism ; Male ; Neutrophils/immunology ; Neutrophils/pathology ; Protein Domains ; Receptor, Interferon alpha-beta/antagonists & inhibitors ; Receptor, Interferon alpha-beta/immunology ; Receptor, Interferon alpha-beta/metabolism ; Receptors, IgG/immunology ; Single-Cell Analysis ; Viral Load/immunology
Czasopismo naukowe
Tytuł :
Type I and III IFN-mediated antiviral actions counteracted by SARS-CoV-2 proteins and host inherited factors.
Autorzy :
Quarleri J; Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS). Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina. Electronic address: .
Delpino MV; Instituto de Inmunología, Genética y Metabolismo (INIGEM). Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina. Electronic address: .
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Źródło :
Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2021 Apr; Vol. 58, pp. 55-65. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Interferon Type I/*physiology
Interferons/*physiology
SARS-CoV-2/*immunology
Viral Proteins/*physiology
Animals ; Antiviral Agents/metabolism ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/pathology ; Genetic Diseases, Inborn/complications ; Genetic Diseases, Inborn/immunology ; Genetic Predisposition to Disease ; Humans ; Immune Evasion/genetics ; Immune Evasion/immunology ; Immunity, Innate/genetics ; Interferon Type I/antagonists & inhibitors ; Interferons/antagonists & inhibitors ; Pandemics ; SARS-CoV-2/pathogenicity
Czasopismo naukowe
Tytuł :
ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?
Autorzy :
Scagnolari C; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy.
Bitossi C; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy.
Viscido A; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy.
Frasca F; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy.
Oliveto G; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy.
Scordio M; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy.
Petrarca L; Department of Maternal Science, Sapienza University of Rome, Rome, Italy.
Mancino E; Department of Maternal Science, Sapienza University of Rome, Rome, Italy.
Nenna R; Department of Maternal Science, Sapienza University of Rome, Rome, Italy.
Riva E; Virology Laboratory, University Campus Bio-Medico of Rome, Rome, Italy.
De Vito C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Midulla F; Department of Maternal Science, Sapienza University of Rome, Rome, Italy.
Antonelli G; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy; Laboratory of Microbiology and Virology; University Hospital 'Policlinico Umberto I,' Rome, Italy.
Pierangeli A; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, affiliated to Istituto Pasteur Italia, Rome, Italy. Electronic address: .
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Źródło :
Cytokine [Cytokine] 2021 Apr; Vol. 140, pp. 155430. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*prevention & control
Epithelial Cells/*drug effects
Gene Expression/*drug effects
Interferons/*pharmacology
SARS-CoV-2/*drug effects
A549 Cells ; Adult ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; COVID-19/virology ; Cell Line, Tumor ; Child ; Cytokines/genetics ; Epithelial Cells/metabolism ; Humans ; Interferons/metabolism ; Lung/cytology ; Middle Aged ; SARS-CoV-2/physiology ; Ubiquitins/genetics
Czasopismo naukowe
Tytuł :
Stimulator of Interferon Genes-associated Vasculopathy with an Onset in Infancy Diagnosed after the Development of Atypical Pulmonary Lesions During Treatment as Juvenile Idiopathic Arthritis.
Autorzy :
Nishida T; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.; Department of Medicine and Biosystemic Science, Kyushu University Faculty of Medicine, Japan.
Nakano K; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Inoue Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Narumi-Kishimoto Y; Medical Genome Center, National Research Institute for Child Health and Development, Japan.
Kaname T; Department of Genome Medicine, National Center for Child Health and Development, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Faculty of Medicine, Japan.
Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
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Źródło :
Internal medicine (Tokyo, Japan) [Intern Med] 2021 Apr 01; Vol. 60 (7), pp. 1109-1114. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Arthritis, Juvenile*/diagnosis
Arthritis, Juvenile*/drug therapy
Arthritis, Juvenile*/genetics
Interferons*
Adolescent ; Child, Preschool ; Humans ; Infant ; Japan ; Male ; Membrane Proteins/genetics ; Mutation
Czasopismo naukowe
Tytuł :
Clinical evidence of an interferon-glucocorticoid therapeutic synergy in COVID-19.
Autorzy :
Lu Y; Department of Biomedical Science, Shenzhen Research Institute, City University of Hong Kong, Kowloon Tong, Hong Kong, China.; Department of Nephrology, Center of Nephrology and Urology, Sun Yat-sen University Seventh Hospital, Shenzhen, Guangdong, China.
Liu F; Department of Infectious Diseases, Suizhou Zengdu Hospital, Suizhou, Hubei, China.
Tong G; Department of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Qiu F; Department of Infectious Diseases, Suizhou Zengdu Hospital, Suizhou, Hubei, China.
Song P; Department of Infectious Diseases, Suizhou Zengdu Hospital, Suizhou, Hubei, China.
Wang X; Intensive Care Unit, Suizhou Zengdu Hospital, Suizhou, Hubei, China.
Zou X; Intensive Care Unit, Suizhou Zengdu Hospital, Suizhou, Hubei, China.
Wan D; Department of Respiratory Medicine, Suizhou Zengdu Hospital, Suizhou, Hubei, China.
Cui M; Department of Pathology, Mount Sinai St. Luke's Roosevelt Hospital Center, New York, NY, USA.
Xu Y; Department of Dermatology, Sun Yat-sen University Seventh Hospital, Shenzhen, Guangdong, China.
Zheng Z; Department of Nephrology, Center of Nephrology and Urology, Sun Yat-sen University Seventh Hospital, Shenzhen, Guangdong, China.
Hong P; Department of Nephrology, Center of Nephrology and Urology, Sun Yat-sen University Seventh Hospital, Shenzhen, Guangdong, China. .; Division of Research and Development, US Department of Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY, USA. .; Department of Cell Biology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Mar 03; Vol. 6 (1), pp. 107. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
SARS-CoV-2*
COVID-19/*drug therapy
Dexamethasone/*administration & dosage
Interferons/*administration & dosage
Adult ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19 Nucleic Acid Testing ; Dexamethasone/agonists ; Drug Synergism ; Female ; Humans ; Interferons/agonists ; Male ; Middle Aged ; Retrospective Studies
Czasopismo naukowe
Tytuł :
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response.
Autorzy :
Oh SJ; BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Korea.
Shin OS; BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Korea.
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Źródło :
Cells [Cells] 2021 Mar 02; Vol. 10 (3). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Nucleocapsid Proteins/*metabolism
DEAD Box Protein 58/*metabolism
Interferons/*metabolism
Receptors, Immunologic/*metabolism
SARS-CoV-2/*metabolism
DEAD Box Protein 58/genetics ; Host-Pathogen Interactions/genetics ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interferons/genetics ; Orthomyxoviridae/genetics ; Orthomyxoviridae/metabolism ; Phosphoproteins/metabolism ; Poly C/pharmacology ; Poly I/pharmacology ; Promoter Regions, Genetic ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Receptors, Immunologic/genetics ; SARS-CoV-2/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcription Factors/metabolism ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Up-Regulation ; Zika Virus/genetics ; Zika Virus/metabolism
Czasopismo naukowe
Tytuł :
Is it time for interferon in low-risk patients with polycythaemia vera?
Autorzy :
Heibl S; Klinikum Wels-Grieskirchen, Wels 4600, Austria. Electronic address: .
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Źródło :
The Lancet. Haematology [Lancet Haematol] 2021 Mar; Vol. 8 (3), pp. e162-e163. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
Interferons/*therapeutic use
Polycythemia Vera/*drug therapy
Antiviral Agents/pharmacology ; Female ; Humans ; Interferons/pharmacology ; Male
Czasopismo naukowe
Tytuł :
Dysregulated Interferon Response Underlying Severe COVID-19.
Autorzy :
Lopez L; Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, 3500 John A. Merritt Boulevard, Nashville, TN 37209, USA.
Sang PC; Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, 3500 John A. Merritt Boulevard, Nashville, TN 37209, USA.
Tian Y; Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, 3500 John A. Merritt Boulevard, Nashville, TN 37209, USA.
Sang Y; Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, 3500 John A. Merritt Boulevard, Nashville, TN 37209, USA.
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Źródło :
Viruses [Viruses] 2020 Dec 13; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Antiviral Agents/*immunology
COVID-19/*immunology
Interferons/*immunology
SARS-CoV-2/*pathogenicity
Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/pathology ; Disease Progression ; Humans ; Interferons/deficiency ; Interferons/therapeutic use ; Kinetics ; Prognosis ; Signal Transduction ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/pathology
Czasopismo naukowe
Tytuł :
Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway.
Autorzy :
Rojas JM; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación Agraria Y Alimentaria, Ctra Algete a El Casar km 8, 28130, Valdeolmos, Madrid, Spain.
Alejo A; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación Agraria Y Alimentaria, Ctra Algete a El Casar km 8, 28130, Valdeolmos, Madrid, Spain.
Martín V; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación Agraria Y Alimentaria, Ctra Algete a El Casar km 8, 28130, Valdeolmos, Madrid, Spain.
Sevilla N; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación Agraria Y Alimentaria, Ctra Algete a El Casar km 8, 28130, Valdeolmos, Madrid, Spain. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Feb; Vol. 78 (4), pp. 1423-1444. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Host-Pathogen Interactions/*genetics
Immunity, Innate/*genetics
Interferons/*genetics
Virus Diseases/*genetics
Humans ; Immune Evasion/genetics ; Interferon-alpha/genetics ; Interferon-alpha/immunology ; Interferons/classification ; Interferons/immunology ; Signal Transduction ; Virus Diseases/immunology
Czasopismo naukowe
Tytuł :
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists.
Autorzy :
Yuen CK; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Lam JY; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Wong WM; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Mak LF; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Wang X; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Chu H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Cai JP; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Jin DY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
To KK; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.; Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Chan JF; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.; Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Yuen KY; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.; Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Kok KH; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 1418-1428.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*metabolism
Coronavirus Infections/*metabolism
Endoribonucleases/*metabolism
Exoribonucleases/*metabolism
Interferons/*antagonists & inhibitors
Interferons/*metabolism
Methyltransferases/*metabolism
Pneumonia, Viral/*metabolism
RNA Helicases/*metabolism
Viral Nonstructural Proteins/*metabolism
Viral Proteins/*metabolism
Betacoronavirus/genetics ; COVID-19 ; Cell Line ; Coronavirus Infections/genetics ; Coronavirus Infections/virology ; Endoribonucleases/genetics ; Exoribonucleases/genetics ; Host-Pathogen Interactions ; Humans ; Interferons/genetics ; Methyltransferases/genetics ; Pandemics ; Pneumonia, Viral/genetics ; Pneumonia, Viral/virology ; RNA Helicases/genetics ; SARS-CoV-2 ; Viral Nonstructural Proteins/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Examining the Role of NF-E2-Related Factor 2 in Lupus: Comment on the Article by Han et al.
Autorzy :
Xu WD; Southwest Medical University, luzhou, China.
Huang AF; Affiliated Hospital of Southwest Medical University, Luzhou, China.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2021 Jan; Vol. 73 (1), pp. 176. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Interferons*
NF-E2-Related Factor 2*
Gene Expression ; Macrophages ; Receptors, Interferon
Raport
Tytuł :
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison.
Autorzy :
Galani IE; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Rovina N; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens, Medical School, 'Sotiria' General Hospital of Chest Diseases, Athens, Greece.
Lampropoulou V; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Triantafyllia V; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Manioudaki M; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Pavlos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Koukaki E; 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens, Medical School, 'Sotiria' General Hospital of Chest Diseases, Athens, Greece.
Fragkou PC; 4th Department of Internal Medicine, Attikon University Hospital, University of Athens Medical School, Athens, Greece.
Panou V; 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens, Medical School, 'Sotiria' General Hospital of Chest Diseases, Athens, Greece.
Rapti V; 4th Department of Internal Medicine, Attikon University Hospital, University of Athens Medical School, Athens, Greece.
Koltsida O; 2nd Respiratory Clinic, 'Sotiria' General Hospital of Chest Diseases, Athens, Greece.
Mentis A; Department of Microbiology, Hellenic Pasteur Institute, Athens, Greece.
Koulouris N; 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens, Medical School, 'Sotiria' General Hospital of Chest Diseases, Athens, Greece.
Tsiodras S; 4th Department of Internal Medicine, Attikon University Hospital, University of Athens Medical School, Athens, Greece.
Koutsoukou A; ICU, 1st Department of Respiratory Medicine, National and Kapodistrian University of Athens, Medical School, 'Sotiria' General Hospital of Chest Diseases, Athens, Greece.
Andreakos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. .; Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London, UK. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Jan; Vol. 22 (1), pp. 32-40. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*immunology
Immunity/*immunology
Influenza, Human/*immunology
Interferon Type I/*immunology
Interferons/*immunology
SARS-CoV-2/*immunology
Antiviral Agents/immunology ; Antiviral Agents/metabolism ; COVID-19/genetics ; COVID-19/virology ; Cytokines/genetics ; Cytokines/immunology ; Disease Progression ; Gene Expression/genetics ; Gene Expression/immunology ; Gene Expression Profiling/methods ; Humans ; Immunity/genetics ; Inflammation/genetics ; Inflammation/immunology ; Influenza, Human/genetics ; Interferon Type I/genetics ; Interferons/genetics ; Length of Stay ; Prognosis ; SARS-CoV-2/physiology ; Viral Load/genetics ; Viral Load/immunology
Czasopismo naukowe
Tytuł :
Reply.
Autorzy :
Han S; University of Florida, Gainesville, FL.
Zhuang H; University of Florida, Gainesville, FL.
Li M; University of Florida, Gainesville, FL.
Yang L; University of Florida, Gainesville, FL.
Lee PY; Boston Children's Hospital, Boston, MA.
Nigrovic PA; Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA.
Reeves WH; University of Florida, Gainesville, FL.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2021 Jan; Vol. 73 (1), pp. 176-178. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Interferons*
Receptors, Interferon*
Macrophages ; NF-E2-Related Factor 2
Raport
Tytuł :
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling.
Autorzy :
Zheng Y; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhuang MW; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Han L; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhang J; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Nan ML; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Gao C; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China. .
Wang PH; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China. .; Suzhou Research Institute, Shandong University, Shandong University, Suzhou, Jiangsu, 215123, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2020 Dec 28; Vol. 5 (1), pp. 299. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
COVID-19/*metabolism
DEAD Box Protein 58/*metabolism
Interferon Type I/*biosynthesis
Interferon-Induced Helicase, IFIH1/*metabolism
Interferons/*biosynthesis
SARS-CoV-2/*metabolism
Viral Matrix Proteins/*metabolism
Animals ; COVID-19/genetics ; Chlorocebus aethiops ; DEAD Box Protein 58/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Interferon Type I/genetics ; Interferon-Induced Helicase, IFIH1/genetics ; Interferons/genetics ; SARS-CoV-2/genetics ; Vero Cells ; Viral Matrix Proteins/genetics
Czasopismo naukowe
Tytuł :
Viral Subpopulation Screening Guides in Designing a High Interferon-Inducing Live Attenuated Influenza Vaccine by Targeting Rare Mutations in NS1 and PB2 Proteins.
Autorzy :
Ghorbani A; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Abundo MC; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Ji H; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Taylor KJM; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Ngunjiri JM; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA .
Lee CW; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA .; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
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Źródło :
Journal of virology [J Virol] 2020 Dec 22; Vol. 95 (2). Date of Electronic Publication: 2020 Dec 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Influenza A virus/*immunology
Influenza Vaccines/*immunology
Interferons/*immunology
RNA-Dependent RNA Polymerase/*genetics
Viral Nonstructural Proteins/*genetics
Viral Proteins/*genetics
Animals ; Antibodies, Viral/immunology ; Cell Line ; Chickens ; Immunity, Innate ; Influenza A virus/genetics ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/genetics ; Influenza in Birds/immunology ; Influenza in Birds/prevention & control ; Interferons/genetics ; Mutation ; Phenotype ; RNA-Dependent RNA Polymerase/immunology ; Vaccination/veterinary ; Vaccines, Attenuated/administration & dosage ; Vaccines, Attenuated/genetics ; Vaccines, Attenuated/immunology ; Viral Nonstructural Proteins/immunology ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection.
Autorzy :
Desai N; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Neyaz A; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Szabolcs A; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Shih AR; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Chen JH; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Thapar V; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Nieman LT; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Solovyov A; Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Mehta A; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.; The Broad Institute, Cambridge, MA, 02142, USA.
Lieb DJ; The Broad Institute, Cambridge, MA, 02142, USA.
Kulkarni AS; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Jaicks C; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Xu KH; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Raabe MJ; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Pinto CJ; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Juric D; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.
Chebib I; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Colvin RB; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Kim AY; Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Monroe R; Advanced Cell Diagnostics, a Bio-Techne Brand, Newark, CA, 94560, USA.
Warren SE; NanoString Inc., Seattle, WA, 98109, USA.
Danaher P; NanoString Inc., Seattle, WA, 98109, USA.
Reeves JW; NanoString Inc., Seattle, WA, 98109, USA.
Gong J; NanoString Inc., Seattle, WA, 98109, USA.
Rueckert EH; NanoString Inc., Seattle, WA, 98109, USA.
Greenbaum BD; Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Hacohen N; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.; The Broad Institute, Cambridge, MA, 02142, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Lagana SM; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Rivera MN; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.; The Broad Institute, Cambridge, MA, 02142, USA.
Sholl LM; Department of Pathology, Brigham and Woman's Hospital, Boston, MA, 02115, USA.
Stone JR; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA. .
Ting DT; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA. .; Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA. .
Deshpande V; Massachusetts General Hospital Cancer Center, Boston, MA, 02114, USA. .; Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 09; Vol. 11 (1), pp. 6319. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/immunology
COVID-19*/metabolism
Host Microbial Interactions*
Lung*/pathology
Lung*/virology
Interferons/*metabolism
Adult ; Aged ; Aged, 80 and over ; Aspartic Acid Endopeptidases/metabolism ; Autopsy ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Epithelial Cells/virology ; Female ; Humans ; Immunity ; Immunohistochemistry ; In Situ Hybridization ; Interferons/genetics ; Macrophages/immunology ; Male ; Middle Aged ; Mucins/genetics ; Mucins/metabolism ; Surface-Active Agents/metabolism ; Transcriptome ; Viral Load
Czasopismo naukowe

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