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Wyszukujesz frazę ""Interleukin-12"" wg kryterium: Temat


Tytuł :
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Autorzy :
Glassman CR; Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mathiharan YK; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jude KM; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Su L; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Panova O; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lupardus PJ; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Spangler JB; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ely LK; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Thomas C; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Skiniotis G; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Garcia KC; Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Feb 18; Vol. 184 (4), pp. 983-999.e24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Interleukin-12/*chemistry
Interleukin-12/*metabolism
Killer Cells, Natural/*metabolism
Receptors, Interleukin/*chemistry
Receptors, Interleukin/*metabolism
T-Lymphocytes/*metabolism
Amino Acid Sequence ; Animals ; Binding Sites ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Epitopes/immunology ; Female ; HEK293 Cells ; Humans ; Immunity ; Interleukin-12/agonists ; Interleukin-12 Subunit p40/chemistry ; Interleukin-12 Subunit p40/metabolism ; Mice, Inbred C57BL ; Models, Molecular ; Neoplasms/immunology ; Neoplasms/pathology ; Protein Structure, Quaternary ; Receptors, Interleukin/ultrastructure ; Receptors, Interleukin-12/metabolism ; Signal Transduction ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE.
Autorzy :
Mondal S; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612.; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612.
Kundu M; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612.
Jana M; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612.; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612.
Roy A; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612.; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612.
Rangasamy SB; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612.; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612.
Modi KK; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612.
Wallace J; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612.
Albalawi YA; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612.
Balabanov R; Department of Neurology, Northwestern University, Chicago, IL 60611.
Pahan K; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612; .; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 01; Vol. 117 (35), pp. 21557-21567. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Encephalomyelitis, Autoimmune, Experimental/*immunology
Interleukin-12 Subunit p40/*immunology
Interleukin-12 Subunit p40/*pharmacology
Receptors, Interleukin-12/*antagonists & inhibitors
Adult ; Animals ; Cells, Cultured ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Female ; Humans ; Interleukin-12/immunology ; Interleukin-12/metabolism ; Interleukin-23/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/blood ; Multiple Sclerosis/immunology ; Protein Binding ; Receptors, Interleukin-12/immunology ; Recombinant Proteins/pharmacology ; Signal Transduction ; Th17 Cells/drug effects ; Th17 Cells/immunology
Czasopismo naukowe
Tytuł :
Novel antibodies that selectively block mouse IL-12 enable the re-evaluation of the role of IL-12 in immune protection and pathology.
Autorzy :
Gaignage M; de Duve Institute, Université de Louvain, Brussels, Belgium.
Uyttenhove C; de Duve Institute, Université de Louvain, Brussels, Belgium.; Ludwig Cancer Research, Brussels, Belgium.
Jones LL; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Bourdeaux C; de Duve Institute, Université de Louvain, Brussels, Belgium.
Chéou P; de Duve Institute, Université de Louvain, Brussels, Belgium.
Mandour MF; de Duve Institute, Université de Louvain, Brussels, Belgium.; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Coutelier JP; de Duve Institute, Université de Louvain, Brussels, Belgium.
Vignali DAA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Van Snick J; de Duve Institute, Université de Louvain, Brussels, Belgium.; Ludwig Cancer Research, Brussels, Belgium.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Jun; Vol. 51 (6), pp. 1482-1493. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Skin Transplantation*
Antibodies, Monoclonal/*metabolism
Encephalomyelitis, Autoimmune, Experimental/*immunology
Graft Rejection/*immunology
Interleukin-12/*metabolism
Mastocytoma/*immunology
Multiple Sclerosis/*immunology
Nidovirales/*physiology
Nidovirales Infections/*immunology
Protein Subunits/*metabolism
Sepsis/*immunology
Animals ; Antibodies, Monoclonal/isolation & purification ; Disease Models, Animal ; Epitopes ; Humans ; Hybridomas ; Interleukin-12/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Neoplasms, Experimental ; Protein Subunits/immunology
Czasopismo naukowe
Tytuł :
Regulation of IL12B Expression in Human Macrophages by TALEN-mediated Epigenome Editing.
Autorzy :
Chen M; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, 430071, China.
Zhu H; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, 430071, China.
Mao YJ; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, 430071, China.
Cao N; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, 430071, China.
Yu YL; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, 430071, China.
Li LY; College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Zhao Q; Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, 430071, China.
Wu M; College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Ye M; College of Life Sciences, Wuhan University, Wuhan, 430072, China. .
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Źródło :
Current medical science [Curr Med Sci] 2020 Oct; Vol. 40 (5), pp. 900-909. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
DNA (Cytosine-5-)-Methyltransferases/*genetics
DNA Methylation/*genetics
Interleukin-12 Subunit p40/*genetics
DNA-Binding Proteins/genetics ; Epigenome/genetics ; Gene Editing ; Gene Expression Regulation/genetics ; Humans ; Interleukin-12/genetics ; Interleukin-23/genetics ; Macrophages/metabolism ; Macrophages/pathology ; Promoter Regions, Genetic/genetics ; Transcription Activator-Like Effector Nucleases/genetics
Czasopismo naukowe
Tytuł :
Increased Circulating T Follicular Helper Cells Induced via IL-12/21 in Patients With Acute on Chronic Hepatitis B Liver Failure.
Autorzy :
Du B; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Teng J; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yin R; Department of Infectious Diseases, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tian Y; Department of Hematology, Children Hospital, Soochow University, Suzhou, China.
Jiang T; Clinical Research Centre, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, China.
Du Y; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cai W; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Mar 31; Vol. 12, pp. 641362. Date of Electronic Publication: 2021 Mar 31 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute-On-Chronic Liver Failure/*immunology
Hepatitis B, Chronic/*immunology
Interleukin-12/*blood
Interleukins/*blood
T Follicular Helper Cells/*immunology
Acute-On-Chronic Liver Failure/blood ; Adult ; Female ; Hepatitis B, Chronic/blood ; Humans ; Interleukin-12/immunology ; Interleukins/immunology ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Inhibition of inflammatory cytokine production and proliferation in macrophages by Kunitz-type inhibitors from Echinococcus granulosus.
Autorzy :
Sagasti C; Área Inmunología, Departamento de Biociencias (Facultad de Química) and Cátedra de Inmunología, Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay.
Casaravilla C; Área Inmunología, Departamento de Biociencias (Facultad de Química) and Cátedra de Inmunología, Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay.
Fernández C; Área Inmunología, Departamento de Biociencias (Facultad de Química) and Cátedra de Inmunología, Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay.
Fló M; Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República and Laboratorio de Inmunobiología, Institut Pasteur de Montevideo, Montevideo, Uruguay. Electronic address: .
Díaz Á; Área Inmunología, Departamento de Biociencias (Facultad de Química) and Cátedra de Inmunología, Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay. Electronic address: .
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Źródło :
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2021 Mar; Vol. 242, pp. 111351. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Echinococcus granulosus/*chemistry
Helminth Proteins/*pharmacology
Interleukin-12/*antagonists & inhibitors
Interleukin-6/*antagonists & inhibitors
Macrophages/*drug effects
Proteinase Inhibitory Proteins, Secretory/*pharmacology
Animals ; Cell Proliferation/drug effects ; Gene Expression Regulation ; Helminth Proteins/isolation & purification ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukin-12/genetics ; Interleukin-12/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Kv1.3 Potassium Channel/genetics ; Kv1.3 Potassium Channel/immunology ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Macrophage Colony-Stimulating Factor/pharmacology ; Macrophages/cytology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Primary Cell Culture ; Proteinase Inhibitory Proteins, Secretory/isolation & purification ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology
Czasopismo naukowe
Tytuł :
Hypoxia-responsive nanogel as IL-12 carrier for anti-cancer therapy.
Autorzy :
Zhang C; School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325011, People's Republic of China. Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy Sciences, Wenzhou 325001, People's Republic of China.
Li Q
Wu C
Wang J
Su M
Deng J
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Źródło :
Nanotechnology [Nanotechnology] 2021 Feb 26; Vol. 32 (9), pp. 095107.
Typ publikacji :
Journal Article
MeSH Terms :
Hyaluronic Acid/*chemistry
Interleukin-12/*administration & dosage
Melanoma, Experimental/*drug therapy
Skin Neoplasms/*drug therapy
Animals ; Cell Hypoxia ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Female ; Interleukin-12/chemistry ; Interleukin-12/pharmacology ; Mice ; Nanogels ; Polyethylene Glycols/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Early Differences in Cytokine Production by Severity of Coronavirus Disease 2019.
Autorzy :
Tjan LH; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Furukawa K; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Kiriu T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Nishimura M; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Arii J; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Hino Y; Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
Iwata S; Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
Nishimura Y; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Mori Y; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2021 Apr 08; Vol. 223 (7), pp. 1145-1149.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
COVID-19/*immunology
Interleukin-12/*blood
Interleukin-2/*blood
SARS-CoV-2/*immunology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asymptomatic Infections ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Case-Control Studies ; Female ; Healthy Volunteers ; Humans ; Interleukin-12/immunology ; Interleukin-2/immunology ; Male ; Middle Aged ; RNA, Viral/isolation & purification ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Young Adult
Czasopismo naukowe
Tytuł :
Protein signatures from blood plasma and urine suggest changes in vascular function and IL-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort.
Autorzy :
Yu Y; J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD, 20850, USA.
Singh H; J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD, 20850, USA.
Kwon K; J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD, 20850, USA.
Tsitrin T; J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD, 20850, USA.
Petrini J; Western Connecticut Health Network, 24 Hospital Avenue, Danbury, CT, 06810, USA.
Nelson KE; J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD, 20850, USA.; J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA.
Pieper R; J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD, 20850, USA. .
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Źródło :
GeroScience [Geroscience] 2021 Apr; Vol. 43 (2), pp. 593-606. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Healthy Aging*
Interleukin-12*
Aged ; Aged, 80 and over ; Chronic Disease ; Humans ; Plasma ; Signal Transduction
Czasopismo naukowe
Tytuł :
Suckling by Schistosoma mansoni-infected mothers restored IgG2a and TGF-β production, but not IL-6 and delayed-type hypersensitivity in IL-12/IL-23-deficient mice.
Autorzy :
Silva FLD; Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Laboratório de Imunopatologia e Biologia Molecular, Recife, PE, Brasil.
Silva MDC; Universidade Federal de Pernambuco, Laboratório de Imunopatologia Keizo Asami, Setor de Imunologia, Recife, PE, Brasil.
Holanda GCR; Universidade Federal de Pernambuco, Laboratório de Imunopatologia Keizo Asami, Setor de Imunologia, Recife, PE, Brasil.
Coutinho EM; Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Laboratório de Imunopatologia e Biologia Molecular, Recife, PE, Brasil.
Montenegro SML; Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Laboratório de Imunopatologia e Biologia Molecular, Recife, PE, Brasil.
Morais CNL; Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Laboratório de Imunopatologia e Biologia Molecular, Recife, PE, Brasil.
Souza VMO; Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, Recife, PE, Brasil.
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Źródło :
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2021 Mar 22; Vol. 54, pp. e0744-2020. Date of Electronic Publication: 2021 Mar 22 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-12*
Schistosoma mansoni*
Animals ; Female ; Humans ; Immunoglobulin G ; Interleukin-23 ; Mice ; Mothers ; Transforming Growth Factor beta
Czasopismo naukowe
Tytuł :
Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment.
Autorzy :
Zhang S; Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
Vaida J; Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
Parenti J; Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
Lindsey BA; Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
Xing M; Department of Mechanical Engineering, University of Manitoba, and the Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada.
Li B; Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Mar 17; Vol. 13 (10), pp. 12454-12462. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*administration & dosage
Bone Morphogenetic Protein 2/*administration & dosage
Delayed-Action Preparations/*chemistry
Interleukin-12/*administration & dosage
Nanocapsules/*chemistry
Peptides/*chemistry
Animals ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Biomimetic Materials/chemistry ; Bone Morphogenetic Protein 2/therapeutic use ; Bone and Bones/injuries ; Bone and Bones/microbiology ; Cell Line ; Cirsium/chemistry ; Humans ; Interleukin-12/therapeutic use ; Rats
Czasopismo naukowe
Tytuł :
Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis.
Autorzy :
Uchiyama K; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Takagi T; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.; Department for Medical Innovation and Translational Medical Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Mizushima K; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Kajiwara-Kubota M; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Kashiwagi S; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Toyokawa Y; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Tanaka M; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Hotta Y; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Kamada K; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Ishikawa T; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Konishi H; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
Kishimoto M; Department of Surgical Pathology, Kyoto City Hospital, Kyoto, 604-8845, Japan.
Naito Y; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan. .; Department of Endoscopy and Ultrasound Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. .
Itoh Y; Department of Endoscopy and Ultrasound Medicine, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, 602-8566, Japan.
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Źródło :
BMC gastroenterology [BMC Gastroenterol] 2021 Mar 17; Vol. 21 (1), pp. 122. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Colitis, Ulcerative*/genetics
Interleukin-12*/genetics
Colonoscopy ; Humans ; Intestinal Mucosa ; Recurrence ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Unmetabolized folic acid is associated with TNF-α, IL-1β and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil.
Autorzy :
Steluti J; Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, 01246-904, Brazil. .; Public Policies and Collective Health Department, Health and Society Institute, Federal University of Sao Paulo, Santos, 11015-020, Brazil. .
Miranda AM; Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, 01246-904, Brazil.
De Carli E; Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, 01246-904, Brazil.
Palchetti CZ; Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, 01246-904, Brazil.
Fisberg RM; Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, 01246-904, Brazil.
Marchioni DML; Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, 01246-904, Brazil.
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Źródło :
European journal of nutrition [Eur J Nutr] 2021 Mar; Vol. 60 (2), pp. 1071-1079. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-12*
Tumor Necrosis Factor-alpha*
Adult ; Brazil ; Cross-Sectional Studies ; Folic Acid ; Food, Fortified ; Humans ; Interleukin-1beta
Czasopismo naukowe
Tytuł :
The risk of respiratory tract infections and interstitial lung disease with interleukin 12/23 and interleukin 23 antagonists in patients with autoimmune diseases: A systematic review and meta-analysis.
Autorzy :
Akiyama S; Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois.
Yamada A; Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois; Section of Gastroenterology, Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.
Micic D; Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois.
Sakuraba A; Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois. Electronic address: .
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Źródło :
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2021 Mar; Vol. 84 (3), pp. 676-690. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Antibodies, Monoclonal/*adverse effects
Autoimmune Diseases/*drug therapy
Interleukin-12/*antagonists & inhibitors
Interleukin-23/*antagonists & inhibitors
Lung Diseases, Interstitial/*epidemiology
Respiratory Tract Infections/*epidemiology
Autoimmune Diseases/immunology ; Humans ; Interleukin-12/immunology ; Interleukin-23/immunology ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/immunology ; Randomized Controlled Trials as Topic ; Respiratory Tract Infections/chemically induced ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/microbiology
Czasopismo naukowe
Tytuł :
Suppression of Serum Interferon-γ Levels as a Potential Measure of Response to Ustekinumab Treatment in Patients With Systemic Lupus Erythematosus.
Autorzy :
Cesaroni M; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Seridi L; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Loza MJ; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Schreiter J; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Sweet K; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Franks C; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Ma K; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Orillion A; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Campbell K; Janssen Research & Development, LLC, Spring House, Pennsylvania.
M Gordon R; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Branigan P; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Lipsky P; AMPEL BioSolutions, LLC, Charlottesville, Virginia.
van Vollenhoven R; Amsterdam Rheumatology and Immunology Center, Amsterdam, The Netherlands.
Hahn BH; University of California, Los Angeles.
Tsokos GC; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Chevrier M; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Rose S; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Baribaud F; Janssen Research & Development, LLC, Spring House, Pennsylvania.
Jordan J; Janssen Research & Development, LLC, Cambridge, Massachusetts.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2021 Mar; Vol. 73 (3), pp. 472-477. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon-gamma/*immunology
Interleukin-12 Subunit p40/*immunology
Lupus Erythematosus, Systemic/*drug therapy
Ustekinumab/*therapeutic use
Adolescent ; Adult ; Aged ; Female ; Humans ; Interleukin-12 Subunit p40/antagonists & inhibitors ; Interleukin-17/immunology ; Interleukin-23/immunology ; Interleukins/immunology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged ; Proteomics ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways.
Autorzy :
Sharma N; Department of Cardiovascular Medicine University of Missouri Columbia MO.; Dalton Cardiovascular Research Center University of Missouri Columbia MO.
Hans CP; Department of Cardiovascular Medicine University of Missouri Columbia MO.; Dalton Cardiovascular Research Center University of Missouri Columbia MO.; Department of Medical Pharmacology and Physiology University of Missouri Columbia MO.
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Źródło :
Journal of the American Heart Association [J Am Heart Assoc] 2021 Feb 02; Vol. 10 (3), pp. e017633. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Aorta, Abdominal/*metabolism
Aortic Aneurysm, Abdominal/*etiology
Connective Tissue Growth Factor/*genetics
Interleukin-12 Subunit p40/*deficiency
Matrix Metalloproteinase 2/*genetics
RNA/*genetics
Aged ; Animals ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/physiopathology ; Aortic Aneurysm, Abdominal/genetics ; Aortic Aneurysm, Abdominal/metabolism ; Blotting, Western ; Cells, Cultured ; Connective Tissue Growth Factor/biosynthesis ; Disease Models, Animal ; Electrocardiography ; Female ; Humans ; Interleukin-12 Subunit p40/blood ; Male ; Matrix Metalloproteinase 2/biosynthesis ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Ultrasonography ; Vascular Stiffness/physiology
Czasopismo naukowe
Tytuł :
Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.
Autorzy :
Eede P; Department of Neuropathology, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Obst J; Department of Neuropathology, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Benke E; Department of Neuropathology, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Yvon-Durocher G; Department of Neuropathology, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Richard BC; Department of Neuropathology, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Gimber N; Advanced Medical Bioimaging Core Facility (AMBIO), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Schmoranzer J; Advanced Medical Bioimaging Core Facility (AMBIO), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Böddrich A; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Wanker EE; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Prokop S; Department of Neuropathology, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Heppner FL; Department of Neuropathology, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Cluster of Excellence, NeuroCure, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.
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Źródło :
EMBO reports [EMBO Rep] 2020 Mar 04; Vol. 21 (3), pp. e48530. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/genetics
Interleukin-12/*deficiency
Interleukin-23 Subunit p19/*deficiency
Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Brain/metabolism ; Disease Models, Animal ; Female ; Interleukin-12/genetics ; Interleukin-12 Subunit p40/deficiency ; Interleukin-12 Subunit p40/genetics ; Interleukin-23 Subunit p19/genetics ; Male ; Mice ; Mice, Transgenic ; Plaque, Amyloid
Czasopismo naukowe
Tytuł :
Linarin Protects the Kidney against Ischemia/Reperfusion Injury via the Inhibition of Bioactive ETS2/IL-12.
Autorzy :
Chengyu Y; Department of Nephrology, The Affiliated Hospital of Qingdao University.
Long Z; Department of Nephrology, The Affiliated Hospital of Qingdao University.
Bin Z; Department of Nephrology, The Affiliated Hospital of Qingdao University.
Hong L; Department of Nephrology, The Affiliated Hospital of Qingdao University.
Xuefei S; Department of Nephrology, The Affiliated Hospital of Qingdao University.
Congjuan L; Department of Nephrology, The Affiliated Hospital of Qingdao University.
Caixia C; Department of Geriatrics, The Affiliated Hospital of Qingdao University.
Yan X; Department of Nephrology, The Affiliated Hospital of Qingdao University.
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2021; Vol. 44 (1), pp. 25-31.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*prevention & control
Glycosides/*pharmacology
Interleukin-12/*antagonists & inhibitors
Proto-Oncogene Protein c-ets-2/*antagonists & inhibitors
Acute Kidney Injury/metabolism ; Animals ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Glycosides/chemistry ; Humans ; Interleukin-12/chemistry ; Interleukin-12/metabolism ; Male ; Protective Agents/chemistry ; Protective Agents/pharmacology ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proto-Oncogene Protein c-ets-2/chemistry ; Proto-Oncogene Protein c-ets-2/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Reduced IL-35 in patients with immune thrombocytopenia.
Autorzy :
Sun RJ; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University.
Yuan D; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University.; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Liu SY; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University.
Zhu JJ; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Shan NN; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University.; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
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Źródło :
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis [Blood Coagul Fibrinolysis] 2020 Dec; Vol. 31 (8), pp. 543-550.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Marrow/*pathology
Interleukin-12 Subunit p35/*blood
Interleukins/*blood
Purpura, Thrombocytopenic, Idiopathic/*blood
Adult ; Aged ; Bone Marrow/metabolism ; Down-Regulation ; Female ; Humans ; Interleukin-12 Subunit p35/analysis ; Interleukin-12 Subunit p35/genetics ; Interleukins/analysis ; Interleukins/genetics ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Male ; Middle Aged ; Minor Histocompatibility Antigens/genetics ; Purpura, Thrombocytopenic, Idiopathic/genetics ; Purpura, Thrombocytopenic, Idiopathic/pathology ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Clinical significance of CC16 and IL-12 in bronchoalveolar lavage fluid of various stages of silicosis.
Autorzy :
Zhang S; Department of Laboratory, Zibo Prevention and Treatment Hospital for Occupational Diseases, Zibo, China.
Jia Q; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Song J; Department of Laboratory, Zibo Prevention and Treatment Hospital for Occupational Diseases, Zibo, China.
Tan Q; Department of Laboratory, Zibo Prevention and Treatment Hospital for Occupational Diseases, Zibo, China.
Yu G; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Guo X; Department of Laboratory, Zibo Prevention and Treatment Hospital for Occupational Diseases, Zibo, China.
Zhang H; Department of Laboratory, Zibo Prevention and Treatment Hospital for Occupational Diseases, Zibo, China. .
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Źródło :
Annals of palliative medicine [Ann Palliat Med] 2020 Nov; Vol. 9 (6), pp. 3848-3856.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-12*
Silicosis*/diagnosis
Uteroglobin*
Bronchoalveolar Lavage Fluid ; Enzyme-Linked Immunosorbent Assay ; Humans
Czasopismo naukowe

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