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Wyszukujesz frazę ""Interleukin-2"" wg kryterium: Temat


Tytuł :
An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Autorzy :
Ptacin JL; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. .
Caffaro CE; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Ma L; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
San Jose Gall KM; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Aerni HR; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Acuff NV; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Herman RW; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Pavlova Y; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Pena MJ; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Chen DB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Koriazova LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Shawver LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Joseph IB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA.
Milla ME; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 09; Vol. 12 (1), pp. 4785. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Interleukin-2/*chemistry
Interleukin-2/*metabolism
Interleukin-2/*pharmacology
Animals ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Drug Discovery ; Genetic Engineering ; Humans ; Interleukin-2/genetics ; Interleukin-2 Receptor alpha Subunit ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Lymphocytes/drug effects ; Mice ; Synthetic Biology
Czasopismo naukowe
Tytuł :
Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity.
Autorzy :
Kim J; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
Lee JY; Selecxine, Bio Open Innovation Center #1204, Pohang, Gyeongbuk, Republic of Korea.
Park SY; Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang, Republic of Korea.
Lee YJ; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
Kim MS; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
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Źródło :
Oncoimmunology [Oncoimmunology] 2021 Mar 16; Vol. 10 (1), pp. 1899671. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*
Pharmaceutical Preparations*
Antibodies ; Humans ; Immunotherapy ; Receptors, Interleukin-2
Czasopismo naukowe
Tytuł :
Differential Effects of IL2Rα and IL15Rα over the Stability of the Common Beta-Gamma Signaling Subunits of the IL2 and IL15 Receptors.
Autorzy :
Ponce LF; Molecular System Biology Department, Center of Molecular Immunology, Havana, Havana 11600, Cuba.; Center for Molecular Simulations, Biological Science Department, University of Calgary, Calgary, Alberta, Canada T2N 1N4.
Montalvo G; Molecular System Biology Department, Center of Molecular Immunology, Havana, Havana 11600, Cuba.
Leon K; Molecular System Biology Department, Center of Molecular Immunology, Havana, Havana 11600, Cuba.
Valiente PA; Center for Protein Studies, Faculty of Biology, University of Havana, Havana, Havana 10400, Cuba.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2021 Apr 26; Vol. 61 (4), pp. 1913-1920. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-15 Receptor alpha Subunit*
Interleukin-2*
Interleukin Receptor Common gamma Subunit/genetics ; Interleukin-15 ; Interleukin-2 Receptor alpha Subunit ; Signal Transduction
Czasopismo naukowe
Tytuł :
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms.
Autorzy :
Ward NC; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Lui JB; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Hernandez R; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Yu L; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO.
Struthers M; Immunology Discovery, Bristol-Myers Squibb, Princeton, NJ.
Xie J; Immunology Discovery, Bristol-Myers Squibb, Princeton, NJ.
Santos Savio A; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Dwyer CJ; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Hsiung S; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Yu A; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL.
Malek TR; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL .
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Źródło :
Diabetes [Diabetes] 2020 Nov; Vol. 69 (11), pp. 2400-2413. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2 Receptor alpha Subunit*
Diabetes Mellitus/*metabolism
Interleukin-2/*pharmacology
Receptors, Interleukin-2/*metabolism
Signal Transduction/*physiology
Animals ; Autoantibodies ; Female ; Humans ; Interleukin-2/chemistry ; Mice ; Mice, Inbred Strains ; Recombinant Fusion Proteins/pharmacology ; T-Lymphocyte Subsets/drug effects
Czasopismo naukowe
Tytuł :
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance.
Autorzy :
Dikiy S; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.
Li J; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bai L; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jiang M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Janke L; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zong X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hao X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hoyos B; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Wang ZM; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Xu B; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Fan Y; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Rudensky AY; Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: .
Feng Y; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 May 11; Vol. 54 (5), pp. 931-946.e11. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Lineage/*immunology
Forkhead Transcription Factors/*immunology
Immune Tolerance/*immunology
Interleukin-2/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; Autoimmunity/immunology ; Cell Differentiation/immunology ; Enhancer Elements, Genetic/immunology ; Female ; Humans ; Interleukin-2 Receptor alpha Subunit/immunology ; Male ; Mice ; Receptors, Interleukin-2/immunology ; STAT5 Transcription Factor/immunology ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species.
Autorzy :
Karakus U; Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Sahin D; Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Mittl PRE; Department of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland.
Mooij P; Department of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, Netherlands.
Koopman G; Department of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, Netherlands.
Boyman O; Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland. .; Faculty of Medicine, University of Zurich, CH-8006 Zurich, Switzerland.
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Źródło :
Science translational medicine [Sci Transl Med] 2020 Dec 16; Vol. 12 (574).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*
T-Lymphocytes, Regulatory*
Animals ; Autoimmunity ; Interleukin-2 Receptor alpha Subunit ; Macaca mulatta ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł :
Exploring the Pathogenic Role and Therapeutic Implications of Interleukin 2 in Autoimmune Hepatitis.
Autorzy :
Czaja AJ; Professor Emeritus of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, 200 First Street S.W., Rochester, MN, 55905, USA. .
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Źródło :
Digestive diseases and sciences [Dig Dis Sci] 2021 Aug; Vol. 66 (8), pp. 2493-2512. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hepatitis, Autoimmune/*metabolism
Interleukin-2/*metabolism
Receptors, Interleukin-2/*metabolism
Gene Expression Regulation ; Hepatitis, Autoimmune/therapy ; Humans ; Interleukin-2/genetics ; Interleukin-2/therapeutic use ; Lymphocyte Subsets/drug effects ; Lymphocyte Subsets/physiology ; Receptors, Interleukin-2/genetics
Czasopismo naukowe
Tytuł :
CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade.
Autorzy :
Drerup JM; Department of Cell Systems and Anatomy, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.; Department of Medicine, University of Texas Health San Antonio, Texas.
Deng Y; Department of Medicine, University of Texas Health San Antonio, Texas.
Pandeswara SL; Department of Medicine, University of Texas Health San Antonio, Texas.
Padrón ÁS; Department of Medicine, University of Texas Health San Antonio, Texas.
Reyes RM; Department of Microbiology, Immunology and Molecular Genetics, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.
Zhang X; Sun Yat-sen University, Guangzhou, Guangdong, P.R.China.
Mendez J; Department of Medicine, University of Texas Health San Antonio, Texas.
Liu A; Department of Medicine, University of Texas Health San Antonio, Texas.
Clark CA; Department of Medicine, University of Texas Health San Antonio, Texas.; Department of Microbiology, Immunology and Molecular Genetics, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.
Chen W; Xiangya Medical School, Changsha, Hunan, China.
Conejo-Garcia JR; Department of Immunology, Moffitt Cancer Center, Tampa, Florida.
Hurez V; Department of Medicine, University of Texas Health San Antonio, Texas.
Gupta H; Department of Medicine, University of Texas Health San Antonio, Texas.
Curiel TJ; Department of Medicine, University of Texas Health San Antonio, Texas. .; Department of Microbiology, Immunology and Molecular Genetics, The Graduate School of Biomedical Sciences, University of Texas Health San Antonio, Texas.; Mays Family Cancer Center, University of Texas Health San Antonio, Texas.
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Źródło :
Cancer research [Cancer Res] 2020 Nov 15; Vol. 80 (22), pp. 5063-5075. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*antagonists & inhibitors
Immunotherapy/*methods
Interleukin-2/*pharmacology
Interleukin-2 Receptor beta Subunit/*antagonists & inhibitors
Melanoma, Experimental/*therapy
Ovarian Neoplasms/*therapy
T-Lymphocytes, Regulatory/*cytology
Animals ; Ascites/immunology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Immune Tolerance ; Immunity, Cellular ; Immunologic Memory ; Interleukin-2 Receptor beta Subunit/immunology ; Melanoma, Experimental/immunology ; Mice ; Mice, Inbred C57BL ; Ovarian Neoplasms/immunology ; Phenotype ; Random Allocation ; Receptors, Interleukin-2/metabolism ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/immunology ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Low-dose interleukin-2: A potential treatment for pemphigus vulgaris.
Autorzy :
Long H; Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Provincial Clinical Research Center for Major Skin Diseases and Skin Health, Changsha, Hunan 410011, China.
Liao J; Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Provincial Clinical Research Center for Major Skin Diseases and Skin Health, Changsha, Hunan 410011, China.
Yang M; Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Provincial Clinical Research Center for Major Skin Diseases and Skin Health, Changsha, Hunan 410011, China.
Wang X; Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Provincial Clinical Research Center for Major Skin Diseases and Skin Health, Changsha, Hunan 410011, China.
Zhang G; Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Provincial Clinical Research Center for Major Skin Diseases and Skin Health, Changsha, Hunan 410011, China.
Lu Q; Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Provincial Clinical Research Center for Major Skin Diseases and Skin Health, Changsha, Hunan 410011, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China. Electronic address: .
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Źródło :
Autoimmunity reviews [Autoimmun Rev] 2021 Oct; Vol. 20 (10), pp. 102906. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Letter
MeSH Terms :
Interleukin-2*
Pemphigus*/drug therapy
Humans
Opinia redakcyjna
Tytuł :
Antitumor Effect of IL-2 and TRAIL Proteins Expressed by Recombinant Salmonella in Murine Bladder Cancer Cells.
Autorzy :
de Lima Fragelli BD; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil, .
Camillo L; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
de Almeida Rodolpho JM; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
de Godoy KF; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
de Castro CA; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
Brassolatti P; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
da Silva AJ; Laboratório de Fábrica Celular, Departamento de Engenharia Química, Universidade Federal de São Carlos, São Carlos, Brazil.
Borra RC; Laboratório de Imunologia Aplicada, Departamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos, Brazil.
de Freitas Anibal F; Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2021 Aug 07; Vol. 55 (4), pp. 460-476.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-2/*immunology
Microorganisms, Genetically-Modified/*immunology
Salmonella/*immunology
TNF-Related Apoptosis-Inducing Ligand/*immunology
Urinary Bladder Neoplasms/*immunology
Urinary Bladder Neoplasms/*therapy
Animals ; Cell Line, Tumor ; Interleukin-2/biosynthesis ; Interleukin-2/genetics ; Mice ; Microorganisms, Genetically-Modified/genetics ; Microorganisms, Genetically-Modified/metabolism ; Salmonella/genetics ; Salmonella/metabolism ; TNF-Related Apoptosis-Inducing Ligand/biosynthesis ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients.
Autorzy :
Buhelt S; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark. Electronic address: .
Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Mahler MR; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Cobanovic S; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Börnsen L; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Ammitzbøll C; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Oturai AB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2021 Sep; Vol. 54, pp. 103140. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-2 Receptor alpha Subunit*/genetics
Multiple Sclerosis*/genetics
Biomarkers ; Healthy Volunteers ; Humans ; Inflammation/genetics ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata.
Autorzy :
Aşkın Ö; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Yücesoy SN; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. Electronic address: .
Coşkun E; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Engin B; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Serdaroğlu S; Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
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Źródło :
Anais brasileiros de dermatologia [An Bras Dermatol] 2021 Sep-Oct; Vol. 96 (5), pp. 551-557. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alopecia Areata*/drug therapy
Interleukin-2*
Adolescent ; Humans ; Interleukin-15 ; Interleukin-17 ; Interleukin-4 ; Interleukins ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Faster speed of onset of the depressive episode is associated with lower cytokine serum levels (IL-2, -4, -6, -10, TNF-α and IFN-γ) in patients with major depression.
Autorzy :
Buspavanich P; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Adli M; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany.
Himmerich H; Department of Psychological Medicine, King's College London, London, United Kingdom; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.
Berger M; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Busche M; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Schlattmann P; Department of Statistics, Informatics and Data Science, Jena University Hospital, Jena, Germany.
Bopp S; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Bschor T; Department of Psychiatry and Psychotherapy, Technical University of Dresden Medical School, Dresden, Germany.
Richter C; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Klinikum Kaulsdorf, Berlin, Germany.
Steinacher B; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany.
Stoppel C; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany.
Hindinger C; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Meyer S; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Hoffmann K; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Stamm T; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Gabriel A; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Merkl A; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany.
Goerke-Arndt F; Department of Psychiatry and Psychotherapy, Oberhavel-Kliniken, Henningsdorf, Germany.
Köhler S; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Sterzer P; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Heinz A; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany.
Behr J; Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Faculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School, Potsdam, Germany; Research Department of Experimental and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Mitte, Germany.
Fakhri H; Department of Physiology, University of Tübingen, Tübingen, Germany.
Lang F; Department of Physiology, University of Tübingen, Tübingen, Germany.
Lang UE; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics, Basel, Switzerland.
Ricken R; Department of Psychiatry and Psychotherapy, Charité -Universitätmedizin Berlin, Campus Mitte, Berlin, Germany. Electronic address: .
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Źródło :
Journal of psychiatric research [J Psychiatr Res] 2021 Sep; Vol. 141, pp. 287-292. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depressive Disorder, Major*
Interleukin-2*
Cytokines ; Depression ; Humans ; Interferon-gamma ; Retrospective Studies ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
Drug-induced liver injury and prospect of cytokine based therapy; A focus on IL-2 based therapies.
Autorzy :
Kumar N; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America. Electronic address: .
Surani S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Udeani G; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Mathew S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
John S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Sajan S; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America.
Mishra J; Irma Lerma Rangel College of Pharmacy, Texas A&M University System, Kingsville, TX 78363, United States of America. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119544. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chemical and Drug Induced Liver Injury/*drug therapy
Cytokines/*therapeutic use
Interleukin-2/*therapeutic use
Liver/*drug effects
Analgesics, Non-Narcotic/adverse effects ; Animals ; Chemical and Drug Induced Liver Injury/pathology ; Cytokines/pharmacology ; Humans ; Inflammation/drug therapy ; Inflammation/pathology ; Interleukin-2/pharmacology ; Liver/pathology
Czasopismo naukowe
Tytuł :
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.
Autorzy :
Mullins GN; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA.
Valentine KM; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA.
Al-Kuhlani M; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.
Davini D; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.
Jensen KDC; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA.
Hoyer KK; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA. .; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA. .; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 15; Vol. 10 (1), pp. 21994. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Interleukin-2 Receptor alpha Subunit/*deficiency
T-Lymphocytes, Regulatory/*immunology
Animals ; Apoptosis ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Erythrocytes/metabolism ; Immunologic Memory ; Interleukin-2/metabolism ; Interleukin-2 Receptor alpha Subunit/metabolism ; Kinetics ; Lymphocyte Activation/immunology ; Mice, Inbred BALB C ; Mice, Knockout ; Thymus Gland/growth & development
Czasopismo naukowe
Tytuł :
IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer.
Autorzy :
Furlan SN; Fred Hutchinson Cancer Research Center and Department of Pediatrics, University of Washington, Seattle, WA.
Singh K; Cincinnati Children's Hospital, Cincinnati, OH.
Lopez C; Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, WA.
Tkachev V; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
Hunt DJ; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
Hibbard J; Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, WA.
Betz KM; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
Blazar BR; Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN; and.
Trapnell C; Department of Genome Sciences, University of Washington, Seattle, WA.
Kean LS; Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.
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Źródło :
Blood advances [Blood Adv] 2020 Apr 28; Vol. 4 (8), pp. 1594-1605.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*
T-Lymphocytes, Regulatory*
Adoptive Transfer ; Animals ; Interleukin-2 Receptor alpha Subunit ; Sirolimus/pharmacology
Czasopismo naukowe
Tytuł :
Overproduction of IL-2 by Cbl-b deficient CD4 T cells provides resistance against regulatory T cells.
Autorzy :
Han S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Chung DC; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
St Paul M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Liu ZQ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Garcia-Batres C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Elford AR; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Tran CW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Chapatte L; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Ohashi PS; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
Oncoimmunology [Oncoimmunology] 2020 Apr 07; Vol. 9 (1), pp. 1737368. Date of Electronic Publication: 2020 Apr 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2*/genetics
T-Lymphocytes, Regulatory*/metabolism
Animals ; Interleukin-2 Receptor alpha Subunit ; Mice, Inbred C57BL ; Signal Transduction ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Phase II study of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma.
Autorzy :
Kawai H; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan.
Ando K; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan.
Maruyama D; Department of Hematology, National Cancer Center Hospital, National Cancer Center Hospital, Tokyo, Japan.
Yamamoto K; Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan.
Kiyohara E; Department of Dermatology, Osaka University Hospital, Osaka, Japan.
Terui Y; Department of Hematology Oncology, The Cancer Institute Hospital of JFCR, Tokyo, Japan.
Fukuhara N; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan.
Miyagaki T; Department of Dermatology, The University of Tokyo Hospital, Tokyo, Japan.
Tokura Y; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Sakata-Yanagimoto M; Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan.
Igarashi T; Department of Hematology, Gunma Cancer Center, Ota, Japan.
Kuroda J; Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Fujita J; Department of Dermatology, Osaka University Hospital, Osaka, Japan.
Uchida T; Department of Hematology and Oncology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan.
Ishikawa T; Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.
Yonekura K; Department of Dermatology, Imamura General Hospital, Kagoshima, Japan.
Kato K; Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka, Japan.
Nakanishi T; Eisai Co., Ltd., Tokyo, Japan.
Nakai K; Eisai Co., Ltd., Tokyo, Japan.
Matsunaga R; Eisai Co., Ltd., Tokyo, Japan.
Tobinai K; Department of Hematology, National Cancer Center Hospital, National Cancer Center Hospital, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2426-2435. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study
MeSH Terms :
Interleukin-2/*administration & dosage
Lymphoma, T-Cell, Cutaneous/*drug therapy
Lymphoma, T-Cell, Peripheral/*drug therapy
Neoplasm Recurrence, Local/*drug therapy
Recombinant Fusion Proteins/*administration & dosage
Administration, Intravenous ; Binding Sites ; Diphtheria Toxin/administration & dosage ; Diphtheria Toxin/adverse effects ; Diphtheria Toxin/chemistry ; Diphtheria Toxin/genetics ; Diphtheria Toxin/pharmacokinetics ; Drug Administration Schedule ; Female ; Humans ; Interleukin-2/adverse effects ; Interleukin-2/chemistry ; Interleukin-2/genetics ; Interleukin-2/pharmacokinetics ; Japan ; Lymphoma, T-Cell, Cutaneous/blood ; Lymphoma, T-Cell, Peripheral/blood ; Male ; Neoplasm Recurrence, Local/blood ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/pharmacokinetics ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing CD25 (IL2RA).
Autorzy :
Akman B; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.; İzmir Biomedicine and Genome Center (IBG), İzmir, Turkey.
Hu X; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.
Liu X; Department of Pathology, City of Hope, Duarte, California, USA.
Hatipoğlu T; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.; İzmir Biomedicine and Genome Center (IBG), İzmir, Turkey.
You H; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
Chan WC; Department of Pathology, City of Hope, Duarte, California, USA.
Küçük C; İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylül University (DEU), İzmir, Turkey.; İzmir Biomedicine and Genome Center (IBG), İzmir, Turkey.; Department of Medical Biology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 May; Vol. 109 (5), pp. 901-914. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-2/*metabolism
Interleukin-2 Receptor alpha Subunit/*metabolism
Killer Cells, Natural/*cytology
Killer Cells, Natural/*metabolism
Positive Regulatory Domain I-Binding Factor 1/*metabolism
Cell Line ; Cell Proliferation ; Down-Regulation/genetics ; Female ; Humans ; Interleukin-2 Receptor alpha Subunit/genetics ; Introns/genetics ; Lymphocyte Activation/immunology ; Male ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Zinc deficiency leads to reduced interleukin-2 production by active gene silencing due to enhanced CREMα expression in T cells.
Autorzy :
Kloubert V; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Wessels I; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Wolf J; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Blaabjerg K; Department of Animal Science - Animal Nutrition and Physiology, Aarhus University/Foulum, Blichers Allé 20, 8830, Tjele, Denmark.
Janssens V; Laboratory of Protein Phosphorylation & Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven & LKI (Leuven Cancer Institute, KU Leuven), Leuven, Belgium.
Hapala J; Helmholtz Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074, Aachen, Germany; Institute of Biomedical Engineering, Department of Cell Biology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Wagner W; Helmholtz Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074, Aachen, Germany; Institute of Biomedical Engineering, Department of Cell Biology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Rink L; Institute of Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany. Electronic address: .
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Źródło :
Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2021 May; Vol. 40 (5), pp. 3263-3278. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Cyclic AMP Response Element Modulator/*immunology
Gene Expression/*genetics
Interleukin-2/*biosynthesis
T-Lymphocytes/*immunology
Zinc/*deficiency
Zinc/*immunology
Animals ; Cyclic AMP Response Element Modulator/genetics ; Disease Models, Animal ; Gene Expression/immunology ; Humans ; In Vitro Techniques ; Interleukin-2/genetics ; Interleukin-2/immunology ; Swine
Czasopismo naukowe

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