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Tytuł :
Weight gain in patients with severe atopic dermatitis treated with dupilumab: a cohort study.
Autorzy :
Johansson EK; Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 77, Stockholm, Sweden. .; Dermatological and Venereal Clinic, Södersjukhuset, SE-118 83, Stockholm, Sweden. .
Ivert LU; Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 77, Stockholm, Sweden.; Department of Dermatology, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.
Bradley B; Department of Dermatology, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.
Lundqvist M; Department of Dermatology, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.
Bradley M; Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 77, Stockholm, Sweden.; Department of Dermatology, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.
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Źródło :
BMC dermatology [BMC Dermatol] 2020 Sep 22; Vol. 20 (1), pp. 8. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal, Humanized/*adverse effects
Dermatitis, Atopic/*drug therapy
Interleukin-4 Receptor alpha Subunit/*antagonists & inhibitors
Weight Gain/*drug effects
Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Interleukin-13/antagonists & inhibitors ; Interleukin-4/antagonists & inhibitors ; Male ; Middle Aged ; Pruritus ; Statistics, Nonparametric ; Young Adult
Czasopismo naukowe
Tytuł :
Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.
Autorzy :
Song X; Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Traub B; Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Shi J; Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Kornmann M; Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 13; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Meta-Analysis; Review
MeSH Terms :
Colonic Neoplasms/*metabolism
Interleukin-13/*metabolism
Interleukin-4/*metabolism
Receptors, Interleukin-13/*metabolism
Receptors, Interleukin-4/*metabolism
Stomach Neoplasms/*metabolism
Animals ; Colonic Neoplasms/etiology ; Colonic Neoplasms/pathology ; Cytokines/metabolism ; Disease Susceptibility ; Humans ; Interleukin-13/genetics ; Interleukin-4/genetics ; Polymorphism, Single Nucleotide ; Protein Binding ; Receptors, Interleukin-13/genetics ; Receptors, Interleukin-4/genetics ; Signal Transduction ; Stomach Neoplasms/etiology ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
Autorzy :
Yang T; Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, PR China.
Wang R; Integrative Medical Center, Chinese PLA General Hospital, Beijing 100039, PR China.
Liu H; Department of Policlinic, Chinese PLA General Hospital, Beijing 100039, PR China.
Wang L; Integrative Medical Center, Chinese PLA General Hospital, Beijing 100039, PR China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Li J; Integrative Medical Center, Chinese PLA General Hospital, Beijing 100039, PR China; Colorectal and Anal Surgery, Chengdu Anorectal Hospital, No 152 Daqiang East Street, Taisheng South Road, Chengdu 610075, PR China.
Wu S; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Chen X; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Yang X; Colorectal and Anal Surgery, Chengdu Anorectal Hospital, No 152 Daqiang East Street, Taisheng South Road, Chengdu 610075, PR China. Electronic address: .
Zhao Y; Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118903. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Berberine/*pharmacology
Gastritis, Atrophic/*drug therapy
Helicobacter Infections/*complications
Helicobacter pylori/*isolation & purification
Interleukin-4/*metabolism
Macrophage Activation/*immunology
STAT6 Transcription Factor/*metabolism
Animals ; Gastritis, Atrophic/etiology ; Gastritis, Atrophic/pathology ; Gene Expression Regulation ; Helicobacter Infections/microbiology ; Humans ; Interleukin-4/genetics ; Macrophage Activation/drug effects ; Male ; Mice ; Rats ; STAT6 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Dupilumab: Basic aspects and applications to allergic diseases.
Autorzy :
Matsunaga K; Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube, Japan. Electronic address: .
Katoh N; Department of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address: .
Fujieda S; Division of Otorhinolaryngology - Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan. Electronic address: .
Izuhara K; Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan. Electronic address: .
Oishi K; Department of Medicine and Clinical Science, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
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Źródło :
Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2020 Apr; Vol. 69 (2), pp. 187-196. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
Hypersensitivity/*immunology
Immunotherapy/*methods
Receptors, Interleukin-4/*metabolism
Th2 Cells/*immunology
Animals ; Humans ; Hypersensitivity/therapy ; Interleukin-13/metabolism ; Interleukin-4/metabolism ; Receptors, Interleukin-4/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.
Autorzy :
Xu J; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.
Chen Z; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.
Yu F; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.
Liu H; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.
Ma C; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.
Xie D; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.
Hu X; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261.
Leak RK; Graduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA 15282.
Chou SHY; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.
Stetler RA; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261.
Shi Y; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261.
Chen J; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213.; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261.
Bennett MVL; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461 .
Chen G; Department of Neurology, Pittsburgh Institute of Brain Disorders & Recovery, University of Pittsburgh, Pittsburgh, PA 15213; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 22; Vol. 117 (51), pp. 32679-32690. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cerebral Hemorrhage/*metabolism
Hematoma/*metabolism
Hemorrhagic Stroke/*metabolism
Interleukin-4/*metabolism
STAT6 Transcription Factor/*metabolism
Animals ; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/pathology ; Disease Models, Animal ; Female ; Hematoma/drug therapy ; Hematoma/pathology ; Hemorrhagic Stroke/drug therapy ; Hemorrhagic Stroke/pathology ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Interleukin-4/administration & dosage ; Interleukin-4/pharmacology ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/metabolism ; Morris Water Maze Test/drug effects ; Phagocytosis/drug effects ; Phagocytosis/physiology ; Rotarod Performance Test ; STAT6 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration.
Autorzy :
Ali SA; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan.
Hanks JE; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan.
Stebbins AW; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan.
Alkhalili O; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan.
Cohen ST; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan.
Chen JY; Department of Biomedical Engineering, Michigan Medicine, Ann Arbor, Michigan.
Smith DR; Department of Biomedical Engineering, Michigan Medicine, Ann Arbor, Michigan.
Dumont CM; Department of Biomedical Engineering, Michigan Medicine, Ann Arbor, Michigan.
Shea LD; Department of Biomedical Engineering, Michigan Medicine, Ann Arbor, Michigan.
Hogikyan ND; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan.
Feldman EL; Department of Neurology, Michigan Medicine, Ann Arbor, Michigan, U.S.A.
Brenner MJ; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan.
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Źródło :
The Laryngoscope [Laryngoscope] 2020 Dec; Vol. 130 (12), pp. 2802-2810. Date of Electronic Publication: 2020 Mar 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-4*
Facial Nerve Injuries/*surgery
Nerve Regeneration/*physiology
Reconstructive Surgical Procedures/*methods
Animals ; Disease Models, Animal ; Lentivirus ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Genetic polymorphisms in the Interleukins IL1B, IL4, and IL6 are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients.
Autorzy :
Cirelli T; Department of Diagnosis and Surgery, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.
Nepomuceno R; Department of Diagnosis and Surgery, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.
Rios ACS; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.
Orrico SRP; Department of Diagnosis and Surgery, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.; Advanced Research Center in Medicine, Union of the Colleges of the Great Lakes (UNILAGO), São José do Rio Preto, Brazil.
Cirelli JA; Department of Diagnosis and Surgery, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.
Theodoro LH; Department of Surgery and Integrated Clinic, São Paulo State University-UNESP, School of Dentistry at Araçatuba, Araçatuba, Brazil.
Barros SP; Department of Periodontology, University of North Carolina at Chapel Hill-UNC, School of Dentistry, Chapel Hill, NC, USA.
Scarel-Caminaga RM; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University-UNESP, School of Dentistry at Araraquara, Araraquara, Brazil.
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Źródło :
Journal of periodontal research [J Periodontal Res] 2020 Dec; Vol. 55 (6), pp. 918-930. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/genetics
Interleukin-1beta*
Interleukin-4*/genetics
Interleukin-6*/genetics
Periodontitis*/complications
Periodontitis*/epidemiology
Periodontitis*/genetics
Brazil ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Interleukins ; Male ; Polymorphism, Single Nucleotide/genetics ; Smoking
Czasopismo naukowe
Tytuł :
DNA methylation of IL-4 gene and the association with childhood trauma in panic disorder.
Autorzy :
Zou Z; Psychosomatic department, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Huang Y; Psychosomatic department, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Wang J; Psychosomatic department, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Min W; Psychosomatic department, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Zhou B; Psychosomatic department, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu 610072, China. Electronic address: .
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Źródło :
Psychiatry research [Psychiatry Res] 2020 Nov; Vol. 293, pp. 113385. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adverse Childhood Experiences/*psychology
Asian Continental Ancestry Group/*psychology
DNA Methylation/*physiology
Interleukin-4/*blood
Panic Disorder/*blood
Panic Disorder/*psychology
Adult ; Adverse Childhood Experiences/trends ; Asian Continental Ancestry Group/genetics ; Biomarkers/blood ; Child ; Female ; Humans ; Interleukin-4/genetics ; Male ; Panic Disorder/genetics ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications.
Autorzy :
Imani D; Department of Immunology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Eslami MM; Department of Hematology, School of Medicine, Tarbiat Modares University (TMU), Tehran, Iran.
Anani-Sarab G; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjnad, Iran.
Aliyu M; Department of Medical Microbiology and Parasitology, Faculty of Clinical Sciences, College of Health Science, Bayero University, Kano, Nigeria.
Razi B; Department of Hematology, School of Medicine, Tarbiat Modares University (TMU), Tehran, Iran.
Rezaei R; Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
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Źródło :
BMC medical genetics [BMC Med Genet] 2020 Nov 23; Vol. 21 (1), pp. 232. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Asthma/*genetics
Interleukin-4/*genetics
African Continental Ancestry Group ; Age Factors ; Alleles ; Asian Continental Ancestry Group ; Asthma/diagnosis ; Asthma/ethnology ; Asthma/immunology ; Case-Control Studies ; European Continental Ancestry Group ; Gene Expression ; Gene Frequency ; Humans ; Interleukin-4/immunology ; Odds Ratio ; Risk Factors
Czasopismo naukowe
Tytuł :
Anti-inflammatory effects of interleukin-4 on intervertebral disc cells.
Autorzy :
Kedong H; Department of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 300, Chicago, IL 60612, USA; Department of Orthopedics, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, China.
Wang D; Department of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 300, Chicago, IL 60612, USA; Department of Orthopedics, Longgang District People's Hospital, Shenzhen, Guangdong, China.
Sagaram M; Department of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 300, Chicago, IL 60612, USA; Arizona College of Osteopathic Medicine, Glendale, AZ, USA.
An HS; Department of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 300, Chicago, IL 60612, USA. Electronic address: .
Chee A; Department of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 300, Chicago, IL 60612, USA.
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Źródło :
The spine journal : official journal of the North American Spine Society [Spine J] 2020 Jan; Vol. 20 (1), pp. 60-68. Date of Electronic Publication: 2019 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Chondrocytes/*drug effects
Interleukin-4/*pharmacology
Cells, Cultured ; Chondrocytes/metabolism ; Humans ; Interleukin-4 Receptor alpha Subunit/genetics ; Interleukin-4 Receptor alpha Subunit/metabolism ; Intervertebral Disc/cytology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Interleukin-4-loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF-β1/Smad pathway for repair of bone defect.
Autorzy :
Zhang J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Shi H; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhang N; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Hu L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jing W; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Pan J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Oct; Vol. 53 (10), pp. e12907. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Regeneration*/drug effects
Cell Differentiation/*drug effects
Hydrogels/*chemistry
Interleukin-4/*pharmacology
Osteogenesis/*drug effects
Signal Transduction/*drug effects
Tissue Scaffolds/*chemistry
Animals ; Apoptosis/drug effects ; Culture Media, Conditioned/pharmacology ; Interleukin-4/chemistry ; Interleukin-4/metabolism ; Macrophage Activation/drug effects ; Macrophages/cytology ; Macrophages/metabolism ; Male ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mice ; Polysaccharides, Bacterial/chemistry ; RAW 264.7 Cells ; Rats ; Rats, Sprague-Dawley ; Smad Proteins/metabolism ; Tissue Engineering ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells.
Autorzy :
Wu Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and.
Konaté MM; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Lu J; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and.
Makhlouf H; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Chuaqui R; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Antony S; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Meitzler JL; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and.
Difilippantonio MJ; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Liu H; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Juhasz A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and.
Jiang G; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and.
Dahan I; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Roy K; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Doroshow JH; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and .; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Nov 01; Vol. 203 (9), pp. 2532-2544. Date of Electronic Publication: 2019 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
DNA Damage*
Colonic Neoplasms/*metabolism
Dual Oxidases/*genetics
Hydrogen Peroxide/*metabolism
Interleukin-17/*pharmacology
Interleukin-4/*pharmacology
Pancreatic Neoplasms/*metabolism
Cell Line, Tumor ; Colonic Neoplasms/pathology ; Humans ; NF-kappa B/physiology ; Oxidation-Reduction ; Pancreatic Neoplasms/pathology ; Receptors, Interleukin-4/physiology ; STAT6 Transcription Factor/physiology ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
IL-4/IL-13 remodeling pathway of COVID-19 lung injury.
Autorzy :
Vaz de Paula CB; School of Medicine, Postgraduate Program of Health Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, Rua Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil. .
de Azevedo MLV; Laboratory of Experimental Pathology, School of Medicine, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
Nagashima S; School of Medicine, Postgraduate Program of Health Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, Rua Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
Martins APC; Laboratory of Experimental Pathology, School of Medicine, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
Malaquias MAS; School of Medicine, Postgraduate Program of Health Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, Rua Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
Miggiolaro AFRDS; School of Medicine, Postgraduate Program of Health Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, Rua Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
da Silva Motta Júnior J; School of Medicine, Postgraduate Program of Health Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, Rua Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
Avelino G; Hospital Marcelino Champagnat, School of Medicine, Pontifical Catholic University of Paraná-PUCPR, R. Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
do Carmo LAP; School of Medicine, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
Carstens LB; School of Medicine, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
de Noronha L; Laboratory of Experimental Pathology, School of Medicine, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155 - Prado Velho, Curitiba, PR, Brazil.
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 29; Vol. 10 (1), pp. 18689. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Infections/*metabolism
Interleukin-13/*metabolism
Interleukin-4/*metabolism
Lung/*metabolism
Pneumonia, Viral/*metabolism
Aged ; Aged, 80 and over ; Biomarkers/metabolism ; COVID-19 ; Coronavirus Infections/pathology ; Female ; Humans ; Interleukin-13/genetics ; Interleukin-4/genetics ; Lung/pathology ; Macrophages/metabolism ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/pathology ; Sphingosine/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Type II Cytokines Fine-Tune Thymic T Cell Selection to Offset Murine Central Nervous System Autoimmunity.
Autorzy :
Barik S; Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Cattin-Roy AN; Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Ukah TK; Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Miller MM; Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Teixeiro E; Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Zaghouani H; Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212 .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Oct 15; Vol. 205 (8), pp. 2039-2045. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dendritic Cells/*immunology
Interleukin-13/*immunology
Interleukin-4/*immunology
Multiple Sclerosis/*immunology
T-Lymphocytes/*immunology
Thymus Gland/*immunology
Animals ; Cellular Microenvironment/genetics ; Cellular Microenvironment/immunology ; Dendritic Cells/pathology ; Disease Models, Animal ; Interleukin-13/genetics ; Interleukin-4/genetics ; Mice ; Mice, Knockout ; Multiple Sclerosis/genetics ; Multiple Sclerosis/pathology ; T-Lymphocytes/pathology ; Thymus Gland/pathology
Czasopismo naukowe
Tytuł :
MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
Autorzy :
Luiz JPM; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Toller-Kawahisa JE; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Viacava PR; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Nascimento DC; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Pereira PT; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Saraiva AL; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Prado DS; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
LeBert M; CNRS, UMR7355, Orléans, France.; Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orléans, France.
Giurisato E; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Tournier C; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Cunha TM; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Cunha FQ; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Quesniaux V; CNRS, UMR7355, Orléans, France.; Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orléans, France.
Ryffel B; CNRS, UMR7355, Orléans, France.; Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orléans, France.
Alves-Filho JC; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Oct; Vol. 108 (4), pp. 1215-1223. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*immunology
Interleukin-4/*immunology
MAP Kinase Kinase 5/*immunology
MAP Kinase Signaling System/*immunology
Macrophages/*immunology
Mitogen-Activated Protein Kinase 7/*immunology
Proto-Oncogene Proteins c-myc/*immunology
Animals ; Antigens, Differentiation/genetics ; Antigens, Differentiation/immunology ; Cell Differentiation/genetics ; Gene Expression Regulation/immunology ; Interleukin-4/genetics ; MAP Kinase Kinase 5/genetics ; MAP Kinase Signaling System/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mitogen-Activated Protein Kinase 7/genetics ; Proto-Oncogene Proteins c-myc/genetics ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/immunology ; STAT6 Transcription Factor/genetics ; STAT6 Transcription Factor/immunology
Czasopismo naukowe
Tytuł :
IL-4 receptor α blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma.
Autorzy :
Russkamp D; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
Aguilar-Pimentel A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, Neuherberg, Germany.
Alessandrini F; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, Neuherberg, Germany.
Fuchs H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, Neuherberg, Germany.
Ohnmacht C; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
Chaker A; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.; Department of Otolaryngology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
de Angelis MH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, Neuherberg, Germany.; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technical University of Munich, Freising, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Ollert M; Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.; Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense, Denmark.
Schmidt-Weber CB; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
Blank S; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
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Źródło :
Allergy [Allergy] 2019 Aug; Vol. 74 (8), pp. 1549-1560. Date of Electronic Publication: 2019 Apr 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Desensitization, Immunologic*/methods
Allergens/*immunology
Asthma/*immunology
Asthma/*therapy
Interleukin-4 Receptor alpha Subunit/*antagonists & inhibitors
Allergens/administration & dosage ; Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Asthma/drug therapy ; Asthma/metabolism ; Cell Differentiation/immunology ; Disease Models, Animal ; Female ; Immunization ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Interleukin-4/biosynthesis ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Mice ; Signal Transduction/drug effects ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
IL-4R is expressed on alpha and beta cells of human pancreata.
Autorzy :
Rajendran S; La Jolla Institute for Immunology, La Jolla, CA, United States of America.
Graef M; La Jolla Institute for Immunology, La Jolla, CA, United States of America.
Chu T; La Jolla Institute for Immunology, La Jolla, CA, United States of America.
von Herrath M; La Jolla Institute for Immunology, La Jolla, CA, United States of America. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 May; Vol. 214, pp. 108394. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin-Secreting Cells/*metabolism
Interleukin-4/*physiology
Interleukin-4 Receptor alpha Subunit/*biosynthesis
Adolescent ; Glucagon/analysis ; Glucagon-Secreting Cells/metabolism ; Glucagon-Secreting Cells/ultrastructure ; Humans ; Insulin/analysis ; Insulin-Secreting Cells/ultrastructure ; Interleukin-4/pharmacology ; Microscopy, Fluorescence ; Protein Subunits
Raport
Tytuł :
Interleukin 4/13 receptors: An overview of genes, expression and functional role in teleost fish.
Autorzy :
Sequeida A; Laboratory of Immunology, Center for Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, 3363 Santiago, Chile.
Maisey K; Laboratory of Immunology, Center for Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, 3363 Santiago, Chile; Laboratory of Comparative Immunology, Center for Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile,Av. Bernardo O'Higgins, 3363 Santiago, Chile.
Imarai M; Laboratory of Immunology, Center for Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, 3363 Santiago, Chile. Electronic address: .
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Źródło :
Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2017 Dec; Vol. 38, pp. 66-72. Date of Electronic Publication: 2017 Sep 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Fish Proteins*/genetics
Fish Proteins*/metabolism
Receptors, Interleukin-4, Type II*/genetics
Receptors, Interleukin-4, Type II*/metabolism
Animals ; Fishes ; Interleukin-13/genetics ; Interleukin-13/metabolism ; Interleukin-4/genetics ; Interleukin-4/metabolism
Czasopismo naukowe
Tytuł :
Kit activates interleukin-4 receptor and effector signal transducer and activator of transcription 6 independent of its cognate ligand in mouse mast cells.
Autorzy :
Sethumadhavan A; Cell Signaling Laboratory, Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India.
Mani M; Cell Signaling Laboratory, Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India.
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Źródło :
Immunology [Immunology] 2020 Apr; Vol. 159 (4), pp. 441-449. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-4/*pharmacology
Mast Cells/*drug effects
Proto-Oncogene Proteins c-kit/*genetics
Receptors, Interleukin-4/*genetics
STAT6 Transcription Factor/*genetics
Stem Cell Factor/*pharmacology
Animals ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Cell Proliferation/drug effects ; Gene Expression Regulation ; Hematopoiesis/drug effects ; Hematopoiesis/genetics ; Hematopoiesis/immunology ; Interleukin-4/genetics ; Interleukin-4/immunology ; Mast Cells/cytology ; Mast Cells/immunology ; Membrane Microdomains/drug effects ; Membrane Microdomains/immunology ; Membrane Microdomains/metabolism ; Mice ; Mice, Inbred C57BL ; Primary Cell Culture ; Proto-Oncogene Proteins c-kit/immunology ; Receptors, Erythropoietin/genetics ; Receptors, Erythropoietin/immunology ; Receptors, Interleukin-3/genetics ; Receptors, Interleukin-3/immunology ; Receptors, Interleukin-4/immunology ; Receptors, Interleukin-7/genetics ; Receptors, Interleukin-7/immunology ; STAT6 Transcription Factor/immunology ; Signal Transduction ; Stem Cell Factor/genetics ; Stem Cell Factor/immunology ; beta-Cyclodextrins/pharmacology
Czasopismo naukowe
Tytuł :
The role of interleukin 4 and IL-4RA in intervertebral disc degeneration: investigation of single nucleotide polymorphisms in genes and a systematic review & meta-analysis of IL-4 expression level.
Autorzy :
Hanaei S; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Abdollahzade S; Division of Neurosurgery, Department of Surgery, Rajayi Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Sadr M; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mirbolouk MH; Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fattahi E; Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Khoshnevisan A; Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Rezaei N; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło :
British journal of neurosurgery [Br J Neurosurg] 2020 Feb; Vol. 34 (1), pp. 66-71. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Interleukin-4/*genetics
Interleukin-4 Receptor alpha Subunit/*genetics
Intervertebral Disc Degeneration/*genetics
Adult ; Case-Control Studies ; Female ; Gene Frequency ; Genotype ; Humans ; Interleukin-4/biosynthesis ; Interleukin-4 Receptor alpha Subunit/biosynthesis ; Intervertebral Disc Degeneration/epidemiology ; Iran/epidemiology ; Male ; Middle Aged ; Pain, Postoperative/epidemiology ; Pain, Postoperative/genetics ; Polymorphism, Single Nucleotide ; Young Adult
Czasopismo naukowe

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