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Tytuł:
Deficiency of interleukin-6 receptor ameliorates PM 2.5 exposure-induced pulmonary dysfunction and inflammation but not abnormalities in glucose homeostasis.
Autorzy:
Peng R; Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Yang W; Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Shao W; Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Pan B; Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Zhu Y; Department of Pathology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Zhang Y; Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Kan H; Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Xu Y; Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China. Electronic address: yanyi_.
Ying Z; Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: .
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Źródło:
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2022 Dec 01; Vol. 247, pp. 114253. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Interleukin-6*/genetics
Insulin Resistance*
Animals ; Mice ; Receptors, Interleukin-6 ; Inflammation/chemically induced ; Homeostasis ; Particulate Matter/toxicity ; Glucose
Czasopismo naukowe
Szczegóły
Tytuł:
Interleukin-6 signaling requires EHD1-mediated alteration of membrane rafts.
Autorzy:
Woo JH; Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.
Park SJ; Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.
Park SM; Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea.
Joe EH; Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea.
Jou I; Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.; Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.
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Źródło:
The FEBS journal [FEBS J] 2022 Oct; Vol. 289 (19), pp. 5914-5932. Date of Electronic Publication: 2022 Apr 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cholera Toxin*/metabolism
Interleukin-6*/genetics
Interleukin-6*/metabolism
Cholesterol/metabolism ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Membrane Microdomains/metabolism ; Membrane Proteins/metabolism ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise.
Autorzy:
Minafra AR; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Chadt A; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.; German Center for Diabetes Research Deutsches Zentrum für Diabetesforschung e.V. (DZD), Partner Düsseldorf, München, Neuherberg, Germany.
Rafii P; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Al-Hasani H; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.; German Center for Diabetes Research Deutsches Zentrum für Diabetesforschung e.V. (DZD), Partner Düsseldorf, München, Neuherberg, Germany.
Behnke K; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
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Źródło:
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Oct 27; Vol. 13, pp. 1028808. Date of Electronic Publication: 2022 Oct 27 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Body Weight*
Physical Conditioning, Animal*
Receptors, Interleukin-6*/genetics
Receptors, Interleukin-6*/metabolism
Animals ; Mice ; Diet, High-Fat/adverse effects ; Insulin Resistance ; Interleukin-6/metabolism ; Obesity/etiology
Czasopismo naukowe
Szczegóły
Tytuł:
Meprin β expression modulates the interleukin-6 mediated JAK2-STAT3 signaling pathway in ischemia/reperfusion-induced kidney injury.
Autorzy:
Abousaad S; Department of Kinesiology, College of Health and Human Sciences, North Carolina A&T State University, Greensboro, North Carolina, USA.
Ahmed F; Department of Kinesiology, College of Health and Human Sciences, North Carolina A&T State University, Greensboro, North Carolina, USA.
Abouzeid A; Department of Kinesiology, College of Health and Human Sciences, North Carolina A&T State University, Greensboro, North Carolina, USA.
Ongeri EM; Department of Kinesiology, College of Health and Human Sciences, North Carolina A&T State University, Greensboro, North Carolina, USA.
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Źródło:
Physiological reports [Physiol Rep] 2022 Sep; Vol. 10 (18), pp. e15468.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Interleukin-6*/metabolism
Reperfusion Injury*/metabolism
Animals ; Caspase 3/metabolism ; Ischemia/metabolism ; Kidney/metabolism ; Male ; Metalloendopeptidases ; Metalloproteases/metabolism ; Mice ; Mice, Knockout ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/metabolism ; Receptors, Interleukin-6/metabolism ; Reperfusion ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis.
Autorzy:
Cui L; NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200090, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China.
Xu F; NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200090, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China.
Xu C; NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200090, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China.
Ding Y; NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200090, China.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China.
Wang S; NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200090, China. .; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China. .; Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, ZhaoZhou Road 413, Shanghai, 200011, China. .
Du M; NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200090, China. .; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200090, China. .; Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, ZhaoZhou Road 413, Shanghai, 200011, China. .; State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, SAR, China. .; Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2022 Nov 24; Vol. 29 (1), pp. 101. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Interleukin-6*/genetics
Nuclear Receptor Subfamily 1, Group D, Member 1*/genetics
Nuclear Receptor Subfamily 1, Group D, Member 1*/metabolism
Animals ; Female ; Mice ; Pregnancy ; Circadian Rhythm/genetics ; Receptors, Interleukin-6 ; Sleep ; CCAAT-Enhancer-Binding Protein-beta/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden.
Autorzy:
Ziegler L; Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden. Electronic address: .
Lundström A; Division of Neurology, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
Havervall S; Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
Thålin C; Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
Gigante B; Cardiovascular Medicine Unit, Department of Medicine Karolinska Institutet, Stockholm Sweden.
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Źródło:
Cytokine [Cytokine] 2022 Nov; Vol. 159, pp. 156020. Date of Electronic Publication: 2022 Aug 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Interleukin-6*
Biomarkers ; C-Reactive Protein ; Cytokine Receptor gp130/metabolism ; Humans ; Hyperplasia ; Longitudinal Studies ; Pandemics ; Receptors, Interleukin-6/metabolism ; SARS-CoV-2 ; Sweden/epidemiology
Czasopismo naukowe
Szczegóły
Tytuł:
Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity.
Autorzy:
Li J; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Jin J; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Li S; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.; Promegene Translational Research Institute, Shenzhen, 518110, China.
Zhong Y; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.; Department of Rheumatology and Immunology, People's Hospital of Xin Jiang Uygur Autonomous Region, Urumqi, 830001, China.
Jin Y; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Zhang X; CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Xia B; CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhu Y; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.; Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education and Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Guo R; Promegene Translational Research Institute, Shenzhen, 518110, China.
Sun X; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Guo J; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Hu F; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Xiao W; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.; Emergency Department, Peking University People's Hospital, Beijing, 100044, China.
Huang F; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Ye H; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Li R; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Zhou Y; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Xiang X; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Yao H; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Yan Q; Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Su L; Center of Medical and Health Analysis, Peking University, Beijing, 100191, China.
Wu L; Department of Rheumatology and Immunology, People's Hospital of Xin Jiang Uygur Autonomous Region, Urumqi, 830001, China.
Luo T; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.; Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education and Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Liu Y; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, 100044, China.
Guo X; Institute for Immunology, School of Medicine, Tsinghua University, Beijing, 100084, China.
Qin J; Promegene Translational Research Institute, Shenzhen, 518110, China.
Qi H; Department of Basic Biomedical Sciences, School of Medicine, Laboratory of Dynamic Immunobiology, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 10084, China.
He J; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
Wang J; CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Li Z; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China.; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Oct; Vol. 9 (30), pp. e2202706. Date of Electronic Publication: 2022 Aug 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arthritis, Rheumatoid*/drug therapy
Arthritis, Rheumatoid*/metabolism
Bacteriocins*/therapeutic use
Microbiota*
Receptors, Interleukin-21*/metabolism
Palatine Tonsil*/microbiology
Receptors, Interleukin-6*/metabolism
Animals ; Humans ; Mice ; Interleukin-6/metabolism ; T-Lymphocytes, Helper-Inducer/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach.
Autorzy:
Aliyu M; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, International Campus, TUMS-IC, Tehran, Iran; Department of Medical Microbiology, Faculty of Clinical Science, College of Health Sciences, Bayero University, Kano, Nigeria.
Zohora FT; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia.
Anka AU; Department of Medical Laboratory Science, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Ali K; Department of Pharmacy Abdul Wali, Khan University Mardan, Pakistan.
Maleknia S; Biopharmaceutical Research Center, AryoGen Pharmed Inc., Alborz University of Medical Sciences, Karaj, Iran.
Saffarioun M; Biopharmaceutical Research Center, AryoGen Pharmed Inc., Alborz University of Medical Sciences, Karaj, Iran.
Azizi G; Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2022 Oct; Vol. 111, pp. 109130. Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Interleukin-6*/metabolism
COVID-19 Drug Treatment*
Antibodies, Monoclonal/therapeutic use ; Cytokines/metabolism ; Humans ; Janus Kinases/metabolism ; Receptors, Interleukin-6 ; STAT Transcription Factors/metabolism ; Signal Transduction
Czasopismo naukowe
Szczegóły
Tytuł:
cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers.
Autorzy:
Hong C; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Schubert M; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Division of Cell Biology and Cancer Genomics Center, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Tijhuis AE; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Requesens M; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Roorda M; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van den Brink A; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ruiz LA; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bakker PL; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van der Sluis T; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pieters W; Division of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Chen M; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wardenaar R; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van der Vegt B; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Spierings DCJ; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
de Bruyn M; Department of Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. .
van Vugt MATM; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. .
Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. .
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Źródło:
Nature [Nature] 2022 Jul; Vol. 607 (7918), pp. 366-373. Date of Electronic Publication: 2022 Jun 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomal Instability*/genetics
Interleukin-6*/antagonists & inhibitors
Interleukin-6*/metabolism
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Nucleotidyltransferases*/genetics
Nucleotidyltransferases*/metabolism
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/metabolism
Triple Negative Breast Neoplasms*/pathology
Antibodies, Monoclonal, Humanized/pharmacology ; Cell Survival/drug effects ; Drug Repositioning ; Humans ; NF-kappa B/metabolism ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Szczegóły
Tytuł:
Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion.
Autorzy:
McNeilly AD; Division of Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK. Electronic address: .
Yianakas A; Division of Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Gallagher JG; Division of Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Tarlton J; Division of Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Ashford ML; Division of Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
McCrimmon RJ; Division of Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
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Źródło:
Molecular metabolism [Mol Metab] 2022 Jul; Vol. 61, pp. 101488. Date of Electronic Publication: 2022 Apr 22.
Typ publikacji:
Journal Article
MeSH Terms:
Glucose*/metabolism
Insulin Resistance*
Receptors, Interleukin-6*/deficiency
Receptors, Interleukin-6*/metabolism
Animals ; Insulin/metabolism ; Insulin Secretion/physiology ; Interleukin-6/metabolism ; Mice
Czasopismo naukowe
Szczegóły
Tytuł:
Increased TNF-α production in response to IL-6 in patients with systemic inflammation without infection.
Autorzy:
Cabrera-Rivera GL; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
Madera-Sandoval RL; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.
León-Pedroza JI; Coordinación de Investigación, Unidad 401-C, Urgencias Médicas, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City, Mexico.; Coordinación de Ciclos Básicos, Universidad Anáhuac, Mexico City, Mexico.
Ferat-Osorio E; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.; División de Investigación en Salud, UMAE Hospital de Especialidades 'Dr. Bernardo Sepúlveda Gutiérrez', Centro Médico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Salazar-Rios E; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.; Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Mexico City, Mexico.
Hernández-Aceves JA; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.; Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Guadarrama-Aranda U; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
López-Macías C; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.; Visiting Professor of Immunology, Nuffield Department of Medicine, University of Oxford, UK.
Wong-Baeza I; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
Arriaga-Pizano LA; Unidad de Investigación Médica en Inmunoquímica, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico City, Mexico.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2022 Aug 19; Vol. 209 (2), pp. 225-235.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-6*/pharmacology
Sepsis*/metabolism
Systemic Inflammatory Response Syndrome*/metabolism
Tumor Necrosis Factor-alpha*/metabolism
Humans ; Inflammation ; Monocytes ; NF-kappa B ; Receptors, Interleukin-6
Czasopismo naukowe
Szczegóły
Tytuł:
Interleukin-6 receptor antagonists in immunopsychiatry: Can they lead to increased interleukin-6 in the central nervous system (CNS) and worsening psychiatric symptoms?
Autorzy:
Mac Giollabhui N; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychology, Temple University, Philadelphia, PA, USA. Electronic address: .
Foster S; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Lowry CA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Mischoulon D; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Raison CL; School of Human Ecology, University of Wisconsin, Madison, Madison, WI, USA; Usona Institute, Fitchberg, WI, USA.
Nyer M; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
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Źródło:
Brain, behavior, and immunity [Brain Behav Immun] 2022 Jul; Vol. 103, pp. 202-204. Date of Electronic Publication: 2022 Apr 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Interleukin-6*
Mental Disorders*/psychology
Central Nervous System ; Humans ; Psychoneuroimmunology ; Receptors, Interleukin-6
Czasopismo naukowe
Szczegóły
Tytuł:
CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.
Autorzy:
Duan H; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Jing L; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.
Xiang J; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.
Ju C; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Wu Z; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Liu J; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.
Ma X; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.
Chen X; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Liu Z; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Feng J; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Yan X; Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.; Joint Laboratory of Nanozymes in Zhengzhou University, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 May; Vol. 9 (13), pp. e2103719. Date of Electronic Publication: 2022 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin Resistance*/physiology
Interleukin-6*/metabolism
Interleukin-6*/therapeutic use
Animals ; CD146 Antigen/metabolism ; Cytokine Receptor gp130/metabolism ; Cytokine Receptor gp130/therapeutic use ; Inflammation/metabolism ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/complications ; Obesity/genetics ; Obesity/metabolism ; Receptors, Interleukin-6
Czasopismo naukowe
Szczegóły
Tytuł:
Local and systemic effects of interleukin-6 (IL-6) in inflammation and cancer.
Autorzy:
Rose-John S; Biochemical Institute, University of Kiel, Germany.
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Źródło:
FEBS letters [FEBS Lett] 2022 Mar; Vol. 596 (5), pp. 557-566. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Interleukin-6*/metabolism
Neoplasms*/genetics
Animals ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Cytokines/metabolism ; Inflammation/metabolism ; Mice ; Receptors, Interleukin-6/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Structure-based 3D-Pharmacophore modeling to discover novel interleukin 6 inhibitors: An in silico screening, molecular dynamics simulations and binding free energy calculations.
Autorzy:
Tran QH; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Pharmaceutical Chemistry Da Nang University of Medical Technology and Pharmacy, Da Nang, Vietnam.
Nguyen QT; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Vo NQ; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Mai TT; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Tran TT; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Pharmaceutical Chemistry Da Nang University of Medical Technology and Pharmacy, Da Nang, Vietnam.
Tran TD; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Le MT; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.; School of Medicine, Vietnam National University Ho Chi Minh City, Linh Trung Ward., Thu Duc Dist., Ho Chi Minh City, Vietnam.
Trinh DT; Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Thai KM; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
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Źródło:
PloS one [PLoS One] 2022 Apr 06; Vol. 17 (4), pp. e0266632. Date of Electronic Publication: 2022 Apr 06 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-6*/antagonists & inhibitors
Molecular Dynamics Simulation*
Humans ; Ligands ; Molecular Docking Simulation ; Receptors, Interleukin-6/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of the JAK1/STAT1 signaling pathway is associated with peroxiredoxin 6 expression levels in human epididymis epithelial cells.
Autorzy:
Shi H; College of Life Science, Yantai University, Yantai, Shandong Province, PR China.
Liu X; Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, PR China.
Wang Y; Qingdao Medical College Affiliated Hospital of Yantai Yuhuangding Hospital, Yantai, Shandong Province, PR China.
Wang H; Qingdao Medical College Affiliated Hospital of Yantai Yuhuangding Hospital, Yantai, Shandong Province, PR China.
Pan B; Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, PR China.
Li J; Key Laboratory of Male Reproductive Health, National Health and Family Planning Commission, Beijing, PR China. .
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Źródło:
Folia histochemica et cytobiologica [Folia Histochem Cytobiol] 2022; Vol. 60 (3), pp. 226-236. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article
MeSH Terms:
Interleukin-6*/metabolism
Peroxiredoxin VI*/genetics
Peroxiredoxin VI*/metabolism
Antioxidants ; DNA ; Epididymis/metabolism ; Epithelial Cells/metabolism ; Humans ; Janus Kinase 1 ; Janus Kinases/metabolism ; Male ; Malondialdehyde ; RNA-Directed DNA Polymerase/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, Interleukin-6/metabolism ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Szczegóły
Tytuł:
EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway.
Autorzy:
Zhu N; Department of Nephrology, Shanghai General Hospital, Shanghai, China.
Guan H; Department of Nephrology, Shanghai General Hospital, Shanghai, China.; Department of Nephrology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.
Wang X; Department of Nephrology, Shanghai General Hospital, Shanghai, China.
Zhang Y; Department of Nephrology, Shanghai General Hospital, Shanghai, China.
Gu L; Department of Nephrology, Shanghai General Hospital, Shanghai, China.
Jia J; Department of Nephrology, Shanghai General Hospital, Shanghai, China.
Wang L; Department of Nephrology, Shanghai General Hospital, Shanghai, China.
Yuan W; Department of Nephrology, Shanghai General Hospital, Shanghai, China.
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Źródło:
International journal of medical sciences [Int J Med Sci] 2023 Jan 01; Vol. 20 (1), pp. 114-124. Date of Electronic Publication: 2023 Jan 01 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Enhancer of Zeste Homolog 2 Protein*/metabolism
Interleukin-6*/metabolism
Peritoneal Dialysis*/adverse effects
Receptors, Interleukin-6*/metabolism
Sp4 Transcription Factor*/metabolism
Animals ; Humans ; Rats ; Human Umbilical Vein Endothelial Cells ; Signal Transduction ; Vascular Endothelial Growth Factor A/metabolism ; Epigenesis, Genetic
Czasopismo naukowe
Szczegóły
Tytuł:
Serum versus synovial fluid interleukin-6 for periprosthetic joint infection diagnosis: a systematic review and meta-analysis of 30 diagnostic test accuracy studies.
Autorzy:
Li J; Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Zhou Q; Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Deng B; Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China. .
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Źródło:
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2022 Dec 24; Vol. 17 (1), pp. 564. Date of Electronic Publication: 2022 Dec 24.
Typ publikacji:
Meta-Analysis; Systematic Review
MeSH Terms:
Interleukin-6*/analysis
Interleukin-6*/blood
Prosthesis-Related Infections*/diagnosis
Prosthesis-Related Infections*/etiology
Synovial Fluid*/chemistry
Humans ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Knee/adverse effects ; Biomarkers/analysis ; Biomarkers/blood ; Diagnostic Tests, Routine/standards ; Sensitivity and Specificity
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interleukin-6 is dispensable in pituitary normal development and homeostasis but needed for pituitary stem cell activation following local injury.
Autorzy:
Laporte E; Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, University of Leuven (KU Leuven), Leuven, Belgium.
De Vriendt S; Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, University of Leuven (KU Leuven), Leuven, Belgium.
Hoekx J; Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, University of Leuven (KU Leuven), Leuven, Belgium.
Vankelecom H; Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, University of Leuven (KU Leuven), Leuven, Belgium.
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Źródło:
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Dec 22; Vol. 13, pp. 1092063. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endocrine Cells*/metabolism
Interleukin-6*/genetics
Interleukin-6*/metabolism
Stem Cells*/metabolism
Pituitary Gland*/growth & development
Pituitary Gland*/physiology
Animals ; Mice ; Cytokines/metabolism ; Homeostasis ; Mice, Knockout
Czasopismo naukowe
Szczegóły
Tytuł:
The association between victimization and inflammation: A meta-analysis.
Autorzy:
Chen XY; Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.
Chan KL; Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. Electronic address: .
Lo CKM; Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.
Ho FK; Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, United Kingdom.
Leung WC; Department of Obstetrics & Gynaecology, Kwong Wah Hospital, Kowloon, Hong Kong.
Ip P; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
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Źródło:
Journal of affective disorders [J Affect Disord] 2023 Feb 15; Vol. 323, pp. 108-122. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Meta-Analysis; Journal Article; Review
MeSH Terms:
Interleukin-6*
Crime Victims*
Adult ; Child ; Humans ; Tumor Necrosis Factor-alpha ; Inflammation/epidemiology ; C-Reactive Protein/metabolism
Czasopismo naukowe
Szczegóły
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