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Wyszukujesz frazę ""Interleukin-6"" wg kryterium: Temat


Tytuł :
Interleukin 6 trans-signaling is a critical driver of lung allograft fibrosis.
Autorzy :
Wheeler DS; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Misumi K; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Walker NM; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Vittal R; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Combs MP; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Aoki Y; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Braeuer RR; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Lama VN; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
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Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2021 Jul; Vol. 21 (7), pp. 2360-2371. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-6*
Lung Transplantation*/adverse effects
Allografts ; Animals ; Fibrosis ; Humans ; Lung/pathology ; Mice ; Receptors, Interleukin-6
Czasopismo naukowe
Tytuł :
Interleukin 6 (IL6) level is a biomarker for functional disease progression within IL6R Ala variant groups in amyotrophic lateral sclerosis patients.
Autorzy :
Wosiski-Kuhn M; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Caress JB; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA, and.
Cartwright MS; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA, and.
Hawkins GA; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Milligan C; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
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Źródło :
Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2021 May; Vol. 22 (3-4), pp. 248-259. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyotrophic Lateral Sclerosis*/genetics
Interleukin-6*/genetics
Biomarkers ; Disease Progression ; Humans ; Longitudinal Studies ; Receptors, Interleukin-6/genetics
Czasopismo naukowe
Tytuł :
Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis.
Autorzy :
Matsumura F; Department of Molecular Biology and Biochemistry, Rutgers-New Brunswick, Piscataway, NJ; .
Polz R; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
Singh S; Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ; and.
Matsumura A; Graduate School of Science, Nagoya University, Nagoya, Japan.
Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
Yamashiro S; Department of Molecular Biology and Biochemistry, Rutgers-New Brunswick, Piscataway, NJ; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Aug 01; Vol. 207 (3), pp. 938-949. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Differentiation/*metabolism
Dendritic Cells/*immunology
Interleukin-6/*metabolism
Microfilament Proteins/*metabolism
Receptors, CCR7/*metabolism
Receptors, Odorant/*metabolism
Animals ; Antibodies, Blocking/pharmacology ; Antigens, Differentiation/genetics ; Cell Differentiation ; Cells, Cultured ; Chemotaxis ; Gene Expression Regulation ; Mice ; Mice, Knockout ; Microfilament Proteins/genetics ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/immunology ; Receptors, Interleukin-6/metabolism ; Receptors, Odorant/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Molecular Mechanism of the Anti-Inflammatory Action of Heparin.
Autorzy :
Litov L; Faculty of Physics, Sofia University 'St. Kl. Ohridski', 5, James Bourchier Blvd, 1164 Sofia, Bulgaria.
Petkov P; Faculty of Physics, Sofia University 'St. Kl. Ohridski', 5, James Bourchier Blvd, 1164 Sofia, Bulgaria.
Rangelov M; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 9, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Ilieva N; Institute of Information and Communication Technologies, Bulgarian Academy of Sciences, 25A, Acad. G. Bonchev Str., 1113 Sofi, Bulgaria.
Lilkova E; Institute of Information and Communication Technologies, Bulgarian Academy of Sciences, 25A, Acad. G. Bonchev Str., 1113 Sofi, Bulgaria.
Todorova N; Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, 2, Gagarin Street, 1113 Sofia, Bulgaria.
Krachmarova E; Institute of Molecular Biology 'Roumen Tsanev',Bulgarian Academy of Sciences, 21, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Malinova K; Institute of Molecular Biology 'Roumen Tsanev',Bulgarian Academy of Sciences, 21, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Gospodinov A; Institute of Molecular Biology 'Roumen Tsanev',Bulgarian Academy of Sciences, 21, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Hristova R; Institute of Molecular Biology 'Roumen Tsanev',Bulgarian Academy of Sciences, 21, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Ivanov I; Institute of Molecular Biology 'Roumen Tsanev',Bulgarian Academy of Sciences, 21, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Nacheva G; Institute of Molecular Biology 'Roumen Tsanev',Bulgarian Academy of Sciences, 21, Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 03; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Anticoagulants/*pharmacology
Heparin, Low-Molecular-Weight/*pharmacology
Interferon-gamma/*immunology
Interleukin-6/*immunology
COVID-19/drug therapy ; COVID-19/immunology ; Cell Line ; Humans ; Models, Molecular ; Receptors, Interleukin-6/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology
Czasopismo naukowe
Tytuł :
The Importance of the Timing of Tocilizumab Administration in Moderate to Severely Ill COVID-19: Single Centered Experience Case series.
Autorzy :
Tenda ED; Division of Respirology and Critical Care, Departement of Internal Medicine, Universitas Indonesia. Dr Cipto Mangunkusumo National General Hospital. Imperial College London. .
Andrian S
Albert S
Asaf MM
Pitoyo CW
Setiati S
Subekti I
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Źródło :
Acta medica Indonesiana [Acta Med Indones] 2021 Jul; Vol. 53 (3), pp. 319-325.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antibodies, Monoclonal, Humanized*/administration & dosage
Antibodies, Monoclonal, Humanized*/adverse effects
COVID-19*/diagnosis
COVID-19*/drug therapy
COVID-19*/immunology
COVID-19*/physiopathology
Cytokine Release Syndrome*/etiology
Cytokine Release Syndrome*/immunology
Cytokine Release Syndrome*/prevention & control
Interleukin-6*/antagonists & inhibitors
Interleukin-6*/blood
Time-to-Treatment*
Receptors, Interleukin-6/*immunology
Adult ; Aged ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Drug Monitoring/methods ; Humans ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Specific Increase in Joint Neutrophil Extracellular Traps and Its Relation to Interleukin 6 in Autoimmune Arthritis.
Autorzy :
Ohyama A; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Osada A; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Kawaguchi H; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.; Ichihara Hospital, Tsukuba, Ibaraki 300-3295, Japan.
Kurata I; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Nishiyama T; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Iwai T; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Ishigami A; Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.
Kondo Y; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Tsuboi H; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Sumida T; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Matsumoto I; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 16; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis, Rheumatoid/*immunology
Extracellular Traps/*metabolism
Interleukin-6/*metabolism
Animals ; Arthritis, Rheumatoid/metabolism ; Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/metabolism ; Citrulline/metabolism ; Extracellular Traps/genetics ; Extracellular Traps/physiology ; Histones/metabolism ; Interleukin-6/immunology ; Joints/immunology ; Leukocyte Elastase/metabolism ; Male ; Mice ; Mice, Inbred DBA ; Neutrophils/metabolism ; Receptors, Interleukin-6/metabolism
Czasopismo naukowe
Tytuł :
Is IL-6 a key cytokine target for therapy in COVID-19?
Autorzy :
Jones SA; Division of Infection & Immunity, The School of Medicine, Cardiff University, Cardiff, Wales, UK. .; Systems Immunity Research Institute, Cardiff University, Cardiff, Wales, UK. .
Hunter CA; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature reviews. Immunology [Nat Rev Immunol] 2021 Jun; Vol. 21 (6), pp. 337-339.
Typ publikacji :
Journal Article; Review
MeSH Terms :
SARS-CoV-2*
COVID-19/*drug therapy
COVID-19/*immunology
Cytokine Release Syndrome/*drug therapy
Cytokine Release Syndrome/*immunology
Interleukin-6/*antagonists & inhibitors
Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/complications ; Cytokine Release Syndrome/etiology ; Cytokines/antagonists & inhibitors ; Humans ; Interleukin-6/blood ; Receptors, Interleukin-6/antagonists & inhibitors ; Severity of Illness Index ; Signal Transduction/drug effects ; Signal Transduction/immunology
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells.
Autorzy :
Yousif AS; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.
Ronsard L; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.
Shah P; The Center for the Study of Inflammatory Bowel Disease, Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Omatsu T; The Center for the Study of Inflammatory Bowel Disease, Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Sangesland M; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.
Bracamonte Moreno T; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.
Lam EC; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.
Vrbanac VD; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.
Balazs AB; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.
Reinecker HC; The Center for the Study of Inflammatory Bowel Disease, Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; The Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Lingwood D; The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 Feb 09; Vol. 54 (2), pp. 235-246.e5. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dendritic Cells/*immunology
Interleukin-6/*blood
Interleukin-6/*immunology
ADAM17 Protein ; Animals ; Cell Differentiation ; Immunity, Humoral ; Immunoglobulin M/immunology ; Inflammation ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/immunology ; Interleukin-6/genetics ; Membrane Glycoproteins/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Plasma Cells/immunology ; Receptors, Interleukin-6/blood ; Receptors, Interleukin-6/immunology ; Signal Transduction/immunology ; Toll-Like Receptor 4/immunology ; Toll-Like Receptor 7/immunology
Czasopismo naukowe
Tytuł :
Serum Concentrations of Interleukin 6 in the General Adult Population: Possible Implications for Anti-IL-6 Therapy in SARS-Cov-2 Infection and IL-6-Related Diseases.
Autorzy :
Alende-Castro V; Department of Internal Medicine, Complejo Hospitalario Universitario, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Alonso-Sampedro M; Department of Clinical Epidemiology, Complejo Hospitalario Universitario, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Gude F; Department of Clinical Epidemiology, Complejo Hospitalario Universitario, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Gonzalez-Quintela A; Department of Internal Medicine, Complejo Hospitalario Universitario, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
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Źródło :
Journal of investigational allergology & clinical immunology [J Investig Allergol Clin Immunol] 2021 Feb 17; Vol. 31 (1), pp. 75-78. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*blood
Interleukin-6/*blood
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/therapeutic use ; Biomarkers/blood ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/immunology ; Cross-Sectional Studies ; Female ; Humans ; Immunologic Factors/therapeutic use ; Interleukin-6/antagonists & inhibitors ; Male ; Middle Aged ; Receptors, Interleukin-6/antagonists & inhibitors ; Reference Values ; Up-Regulation ; Young Adult
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Perspectives on Targeting IL-6 as a Potential Therapeutic Strategy for COVID-19.
Autorzy :
Khaedir Y; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia.; Immunology, Master's Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia.
Kartika R; Division of Metabolic, Endocrinology, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia.
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Źródło :
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2021 Feb; Vol. 41 (2), pp. 37-43.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19/*pathology
Receptors, Interleukin-6/*antagonists & inhibitors
Respiratory Distress Syndrome/*drug therapy
SARS-CoV-2/*immunology
Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/drug therapy ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/prevention & control ; Humans ; Indonesia ; Interleukin-6/immunology ; Janus Kinase 1/antagonists & inhibitors ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase Inhibitors/therapeutic use ; Pyrazoles/therapeutic use ; SARS-CoV-2/drug effects ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Triptolide Inhibits Expression of Inflammatory Cytokines and Proliferation of Fibroblast-like Synoviocytes Induced by IL-6/sIL-6R-Mediated JAK2/STAT3 Signaling Pathway.
Autorzy :
Lin JJ; National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518000, China.; Arthritis Clinical and Research Center, Peking University People's Hospital, Beijing, 100044, China.
Tao K; Arthritis Clinical and Research Center, Peking University People's Hospital, Beijing, 100044, China.
Gao N; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518000, China.
Zeng H; National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518000, China.
Wang DL; National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518000, China.
Yang J; Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, 518000, China. .
Weng J; National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518000, China. .
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Źródło :
Current medical science [Curr Med Sci] 2021 Feb; Vol. 41 (1), pp. 133-139. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Anti-Inflammatory Agents/*pharmacology
Diterpenes/*pharmacology
Interleukin-6/*metabolism
Phenanthrenes/*pharmacology
Synoviocytes/*drug effects
Cell Proliferation ; Cells, Cultured ; Epoxy Compounds/pharmacology ; Humans ; Interleukin-6/genetics ; Janus Kinase 2/metabolism ; Receptors, Interleukin-6/metabolism ; STAT3 Transcription Factor/metabolism ; Synoviocytes/metabolism ; Synoviocytes/physiology
Czasopismo naukowe
Tytuł :
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Autorzy :
Bin S; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China. Electronic address: .
Xin L; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Lin Z; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Jinhua Z; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Rui G; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Xiang Z; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2021 Feb; Vol. 118, pp. 104570. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chondrocytes/*pathology
Gene Expression Regulation/*drug effects
MicroRNAs/*genetics
Receptors, Interleukin-6/*metabolism
Scoliosis/*pathology
Apoptosis ; Case-Control Studies ; Cell Proliferation ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Ferroptosis ; Humans ; Interleukin-6/pharmacology ; Receptors, Interleukin-6/genetics ; Scoliosis/drug therapy ; Scoliosis/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction: A Nested Case-Control Study.
Autorzy :
Zegeye MM; Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Sweden (M.M.Z., D.R., A.S., L.U.L.).
Andersson JSO; Skellefteå Research Unit, Department of Public Health and Clinical Medicine (J.S.O.A.), Umeå University, Sweden.
Wennberg P; Department of Public Health and Clinical Medicine, Family Medicine (P.W.), Umeå University, Sweden.
Repsilber D; Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Sweden (M.M.Z., D.R., A.S., L.U.L.).
Sirsjö A; Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Sweden (M.M.Z., D.R., A.S., L.U.L.).
Ljungberg LU; Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Sweden (M.M.Z., D.R., A.S., L.U.L.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Apr; Vol. 41 (4), pp. 1570-1579. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation Mediators/*blood
Interleukin-6/*blood
Myocardial Infarction/*blood
Adult ; Aged ; Biomarkers/blood ; Case-Control Studies ; Cytokine Receptor gp130/blood ; Female ; Heart Disease Risk Factors ; Humans ; Hypertension/blood ; Hypertension/epidemiology ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Prognosis ; Receptors, Interleukin-6/blood ; Registries ; Risk Assessment ; Smoking/adverse effects ; Sweden/epidemiology ; Time Factors
Czasopismo naukowe
Tytuł :
Audio Interview: A New SARS-CoV-2 Vaccine and a New Look at Treatment.
Autorzy :
Rubin EJ
Baden LR
Morrissey S
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Źródło :
The New England journal of medicine [N Engl J Med] 2021 Mar 04; Vol. 384 (9), pp. e46.
Typ publikacji :
Editorial; Interview
MeSH Terms :
COVID-19 Vaccines*/administration & dosage
COVID-19 Vaccines*/immunology
Antibodies, Monoclonal, Humanized/*therapeutic use
COVID-19/*drug therapy
COVID-19/*prevention & control
Immunologic Factors/*therapeutic use
Receptors, Interleukin-6/*antagonists & inhibitors
SARS-CoV-2/*genetics
Adenoviridae ; Genetic Variation ; Genetic Vectors ; Humans ; Interleukin-6/immunology ; Treatment Outcome ; Vaccine Potency
SCR Protocol :
COVID-19 drug treatment
Opinia redakcyjna
Tytuł :
Can aldosterone increase interleukin-6 levels in Covid-19 pneumonia?
Autorzy :
Campana P; Department of Translational Medical Sciences, University Federico II, Naples, Italy.
Flocco V; Department of Translational Medical Sciences, University Federico II, Naples, Italy.
Aruta F; Department of Neuroscience, University Federico II, Naples, Italy.
Cacciatore F; Department of Translational Medical Sciences, University Federico II, Naples, Italy.
Abete P; Department of Translational Medical Sciences, University Federico II, Naples, Italy.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 622-623. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Aldosterone/*blood
COVID-19/*immunology
Cytokine Release Syndrome/*immunology
Interleukin-6/*blood
COVID-19/complications ; COVID-19/diagnosis ; Female ; Guillain-Barre Syndrome/etiology ; Humans ; Middle Aged ; Receptors, Interleukin-6/blood
Raport
Tytuł :
Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19.
Autorzy :
Kappelmann N; Department of Research in Translational Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany. Electronic address: .
Dantzer R; Department of Symptom Research, University of Texas MD Anderson Cancer Centre, Houston, TX, USA.
Khandaker GM; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
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Źródło :
Psychoneuroendocrinology [Psychoneuroendocrinology] 2021 Sep; Vol. 131, pp. 105295. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*complications
Interleukin-6/*physiology
Mental Disorders/*etiology
Animals ; Anxiety/epidemiology ; Anxiety/etiology ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/psychology ; Cohort Studies ; Depression/epidemiology ; Depression/etiology ; Fatigue/epidemiology ; Fatigue/etiology ; Humans ; Interleukin-6/metabolism ; Interleukin-6/pharmacology ; Mental Disorders/epidemiology ; Neuroimmunomodulation/drug effects ; Neuroimmunomodulation/physiology ; SARS-CoV-2/physiology ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology ; Survivors/statistics & numerical data
SCR Disease Name :
post-acute COVID-19 syndrome
Czasopismo naukowe
Tytuł :
Interleukin-6 controls recycling and degradation, but not internalization of its receptors.
Autorzy :
Flynn CM; Institute of Biochemistry, Kiel University, Kiel, Germany.
Kespohl B; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Daunke T; Institute of Biochemistry, Kiel University, Kiel, Germany.
Garbers Y; Institute of Psychology, Kiel University, Kiel, Germany.
Düsterhöft S; Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany.
Rose-John S; Institute of Biochemistry, Kiel University, Kiel, Germany.
Haybaeck J; Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria; Diagnostic & Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, Graz, Austria.
Lokau J; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Aparicio-Siegmund S; Institute of Biochemistry, Kiel University, Kiel, Germany.
Garbers C; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100434. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokine Receptor gp130/*metabolism
Receptors, Interleukin-6/*metabolism
Cytokine Receptor gp130/genetics ; Cytokines/metabolism ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Interleukin-6/physiology ; Receptors, Interleukin ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/physiology ; Signal Transduction ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".
Autorzy :
Pizzarelli F; Nephrology and Dialysis Unit, SM Annunziata Hospital, ASL Toscana Centro, via dell'Antella, 50012, Firenze, Italy. .
Cantaluppi V; Nephrology and Kidney Transplantation Unit, Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy.
Panichi V; Nephrology and Dialysis Unit, Versilia Hospital, ASL Nord-Ovest, Lido Di Camaiore, Italy.
Toccafondi A; Nephrology and Dialysis Unit, SM Annunziata Hospital, ASL Toscana Centro, via dell'Antella, 50012, Firenze, Italy.
Ferro G; Nephrology and Dialysis Unit, SM Annunziata Hospital, ASL Toscana Centro, via dell'Antella, 50012, Firenze, Italy.
Farruggio S; Nephrology and Kidney Transplantation Unit, Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy.
Grossini E; Lab Physiology, Department Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy.
Dattolo PC; Nephrology and Dialysis Unit, SM Annunziata Hospital, ASL Toscana Centro, via dell'Antella, 50012, Firenze, Italy.
Miniello V; Nephrology and Dialysis Unit, ASL Toscana Centro, Pistoia, Italy.
Migliori M; Nephrology and Dialysis Unit, Versilia Hospital, ASL Nord-Ovest, Lido Di Camaiore, Italy.
Grimaldi C; Nephrology and Dialysis Unit, NSGD Hospital, ASL Toscana Centro, Firenze, Italy.
Casani A; Nephrology and Dialysis Unit, ASL Nord-Ovest, Massa Carrara, Italy.
Borzumati M; Nephrology and Dialysis Unit, ASL VCO, Verbania, Verbano Cusio Ossola, Italy.
Cusinato S; Nephrology and Dialysis Unit, Borgomanero Hospital, ASL NO Novara, Borgomanero, Italy.
Capitanini A; Nephrology and Dialysis Unit, ASL Toscana Centro, Pistoia, Italy.
Quercia A; Nephrology and Dialysis Unit, ASL Biella, Biella, Italy.
Filiberti O; Nephrology and Dialysis Unit, ASL Vercelli, Vercelli, Italy.
Dani L; Nephrology and Dialysis Unit, ASL Toscana Centro, Empoli, Italy.
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Corporate Authors :
Hephaestus study group
Źródło :
Journal of nephrology [J Nephrol] 2021 Oct; Vol. 34 (5), pp. 1701-1710. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Hemodiafiltration*/adverse effects
Interleukin-6*
Adult ; Aged ; Aged, 80 and over ; Citric Acid ; Humans ; Middle Aged ; Prospective Studies ; Renal Dialysis
Czasopismo naukowe
Tytuł :
Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression.
Autorzy :
Tengesdal IW; Department of Medicine, University of Colorado Denver, Aurora, CO, United States.; Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, Netherlands.
Dinarello A; Department of Medicine, University of Colorado Denver, Aurora, CO, United States.; Dipartimento di Biologia, Università degli Studi di Padova, Padova, Italy.
Powers NE; Department of Medicine, University of Colorado Denver, Aurora, CO, United States.
Burchill MA; Department of Medicine, University of Colorado Denver, Aurora, CO, United States.
Joosten LAB; Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, Netherlands.
Marchetti C; Department of Medicine, University of Colorado Denver, Aurora, CO, United States.
Dinarello CA; Department of Medicine, University of Colorado Denver, Aurora, CO, United States.; Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, Netherlands.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Aug 31; Vol. 12, pp. 661323. Date of Electronic Publication: 2021 Aug 31 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-1beta/*immunology
Interleukin-6/*immunology
Melanoma/*immunology
Myeloid-Derived Suppressor Cells/*immunology
NLR Family, Pyrin Domain-Containing 3 Protein/*immunology
STAT3 Transcription Factor/*immunology
Animals ; Cell Line, Tumor ; Humans ; Immune Tolerance/drug effects ; Immune Tolerance/immunology ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Melanoma/metabolism ; Melanoma/pathology ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/immunology ; Melanoma, Experimental/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Immunological ; Myeloid-Derived Suppressor Cells/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nitriles/pharmacology ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Tumor Burden/drug effects ; Tumor Burden/immunology
Czasopismo naukowe
Tytuł :
Interleukin-6 (IL-6) inhibitors as therapeutic agents for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Autorzy :
Pinzon RT; Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, Indonesia; Bethesda Hospital, Yogyakarta, Indonesia. Electronic address: .
Wijaya VO; Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, Indonesia; Bethesda Hospital, Yogyakarta, Indonesia.
Buana RB; Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, Indonesia; Bethesda Hospital, Yogyakarta, Indonesia.
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Źródło :
Journal of infection and public health [J Infect Public Health] 2021 Aug; Vol. 14 (8), pp. 1001-1009. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
COVID-19*
Interleukin-6*
Humans ; Respiration, Artificial ; SARS-CoV-2 ; Treatment Outcome
Czasopismo naukowe

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