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Wyszukujesz frazę ""Interleukin-6"" wg kryterium: Temat


Tytuł :
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Autorzy :
Werner-Klein M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. .
Grujovic A; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Telexos GmbH, Weilheim, Germany.
Irlbeck C; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Obradović M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Wellmera AG, Basel, Switzerland.
Hoffmann M; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Koerkel-Qu H; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Lu X; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Treitschke S; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Köstler C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Botteron C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Weidele K; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Werno C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Polzer B; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Kirsch S; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Gužvić M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Warfsmann J; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Honarnejad K; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Czyz Z; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Feliciello G; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Blochberger I; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Grunewald S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Schneider E; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Haunschild G; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Patwary N; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Guetter S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Huber S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Rack B; Department OB&GYN and CCCLMU, Breast Center, LMU University Hospital, 80337, Munich, Germany.; Department of Gynecology, Ulm University Hospital, Ulm, Germany.
Harbeck N; Department OB&GYN and CCCLMU, Breast Center, LMU University Hospital, 80337, Munich, Germany.
Buchholz S; Clinic of Gynecology and Obstetrics, University Medical Center Regensburg, 93053, Regensburg, Germany.
Rümmele P; Department of Pathology, University of Regensburg, 93053, Regensburg, Germany.; Institute of Pathology, University Hospital, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Heine N; University Center of Plastic-, Aesthetic, Hand- and Reconstructive Surgery, University of Regensburg, Regensburg, Germany.
Rose-John S; Institute of Biochemistry, Christian-Albrechts-Universität Kiel, Kiel, Germany.
Klein CA; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. .; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 05; Vol. 11 (1), pp. 4977. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Signal Transduction*
Interleukin-6/*metabolism
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Bone Marrow/pathology ; Breast/cytology ; Breast Neoplasms/pathology ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Cytokine Receptor gp130/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Humans ; Interleukin-6/genetics ; Mutation ; Neoplasm Metastasis/genetics ; Receptors, Interleukin-6/deficiency ; Receptors, Interleukin-6/metabolism ; Stromal Cells/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome.
Autorzy :
Kang S; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Tanaka T; Medical Affairs Bureau, Osaka Habikino Medical Center, Osaka 583-8588, Japan.
Inoue H; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Ono C; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Hashimoto S; Department of Clinical Laboratory, Osaka Habikino Medical Center, Osaka 583-8588, Japan.
Kioi Y; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Matsumoto H; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Matsuura H; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Matsubara T; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Shimizu K; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Ogura H; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Matsuura Y; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Kishimoto T; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22351-22356. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Subsets: MEDLINE
MeSH Terms :
Signal Transduction*
Cytokine Release Syndrome/*metabolism
Endothelial Cells/*metabolism
Interleukin-6/*metabolism
Plasminogen Activator Inhibitor 1/*metabolism
Adult ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Betacoronavirus ; Burns/metabolism ; Burns/pathology ; Cells, Cultured ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Coronavirus Infections/pathology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/pathology ; Cytokines/blood ; Cytokines/metabolism ; Endothelial Cells/drug effects ; Female ; Humans ; Inflammation ; Interleukin-6/blood ; Male ; Middle Aged ; Pandemics ; Plasminogen Activator Inhibitor 1/blood ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/pathology ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/metabolism ; Respiratory Distress Syndrome, Adult/metabolism ; Respiratory Distress Syndrome, Adult/pathology ; Sepsis/metabolism ; Sepsis/pathology
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study.
Autorzy :
Della-Torre E; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, San Raffaele Hospital, Milano, Lombardia, Italy .; Università Vita-Salute San Raffaele, Milan, Italy.
Campochiaro C; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, San Raffaele Hospital, Milano, Lombardia, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.
Cavalli G; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, San Raffaele Hospital, Milano, Lombardia, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.
De Luca G; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, San Raffaele Hospital, Milano, Lombardia, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.
Napolitano A; Università Vita-Salute San Raffaele, Milan, Italy.; Clinical and Experimental Radiology Unit, Experimental Imaging Center, San Raffaele Hospital, Milan, Italy.
La Marca S; Università Vita-Salute San Raffaele, Milan, Italy.; Clinical and Experimental Radiology Unit, Experimental Imaging Center, San Raffaele Hospital, Milan, Italy.
Boffini N; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, San Raffaele Hospital, Milano, Lombardia, Italy.
Da Prat V; General Medicine and Advanced Care Unit, San Raffaele Hospital, Milan, Italy.
Di Terlizzi G; General Medicine and Advanced Care Unit, San Raffaele Hospital, Milan, Italy.
Lanzillotta M; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, San Raffaele Hospital, Milano, Lombardia, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.
Rovere Querini P; Università Vita-Salute San Raffaele, Milan, Italy.; Internal Medicine, Diabetes & Endocrinology Unit, San Raffaele Hospital, Milan, Italy.
Ruggeri A; Hematology and Bone Marrow Transplant Unit, San Raffaele Hospital, Milan, Italy.
Landoni G; Università Vita-Salute San Raffaele, Milan, Italy.; Department of Anesthesia and Intensive Care, San Raffaele Hospital, Milan, Italy.
Tresoldi M; General Medicine and Advanced Care Unit, San Raffaele Hospital, Milan, Italy.
Ciceri F; Università Vita-Salute San Raffaele, Milan, Italy.; Hematology and Bone Marrow Transplant Unit, San Raffaele Hospital, Milan, Italy.
Zangrillo A; Università Vita-Salute San Raffaele, Milan, Italy.; Department of Anesthesia and Intensive Care, San Raffaele Hospital, Milan, Italy.
De Cobelli F; Università Vita-Salute San Raffaele, Milan, Italy.; Clinical and Experimental Radiology Unit, Experimental Imaging Center, San Raffaele Hospital, Milan, Italy.
Dagna L; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, San Raffaele Hospital, Milano, Lombardia, Italy .; Università Vita-Salute San Raffaele, Milan, Italy.
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Corporate Authors :
SARI-RAF Study Group
SARI-RAF Study Group members
Źródło :
Annals of the rheumatic diseases [Ann Rheum Dis] 2020 Oct; Vol. 79 (10), pp. 1277-1285. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Observational Study
Journal Info :
Publisher: BMJ Country of Publication: England NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
C-Reactive Protein/*immunology
Coronavirus Infections/*drug therapy
Inflammation/*immunology
Interleukin-6/*immunology
Pneumonia, Viral/*drug therapy
Administration, Intravenous ; Anti-Bacterial Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; Bacteremia/epidemiology ; Betacoronavirus ; Cohort Studies ; Coinfection/epidemiology ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Drug Combinations ; Enzyme Inhibitors/therapeutic use ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Italy ; Lopinavir/therapeutic use ; Lung/diagnostic imaging ; Male ; Middle Aged ; Noninvasive Ventilation ; Oxygen Inhalation Therapy ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Proportional Hazards Models ; Receptors, Interleukin-6/antagonists & inhibitors ; Ritonavir/therapeutic use ; Severity of Illness Index ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome
SCR Disease Name :
COVID-19
SCR Protocol :
COVID-19 drug treatment
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Outcomes and biomarker analyses among patients with COVID-19 treated with interleukin 6 (IL-6) receptor antagonist sarilumab at a single institution in Italy.
Autorzy :
Montesarchio V; Department of Medical Oncology, Azienda Ospedaliera dei Colli-Monaldi Hospital, Napoli, Italy.
Parrela R; Department of Infectious Diseases and Infectious Diseases Emergencies, Azienda Ospedaliera dei Colli-Cotugno Hospital, Napoli, Italy.
Iommelli C; Department of Medical Oncology, Azienda Ospedaliera dei Colli-Monaldi Hospital, Napoli, Italy.
Bianco A; Department of Medical Oncology, Azienda Ospedaliera dei Colli-Monaldi Hospital, Napoli, Italy.
Manzillo E; Department of Infectious Diseases and Infectious Diseases Emergencies, Azienda Ospedaliera dei Colli-Cotugno Hospital, Napoli, Italy.
Fraganza F; Critical Area Department, Azienda Ospedaliera dei Colli-Cotugno and Monaldi Hospital, Napoli, Italy.
Palumbo C; Department of Health Services, Azienda Ospedaliera dei Colli-Cotugno and Monaldi Hospital, Napoli, Italy.
Rea G; Department of Health Services, Azienda Ospedaliera dei Colli-Cotugno and Monaldi Hospital, Napoli, Italy.
Murino P; Critical Area Department, Azienda Ospedaliera dei Colli-Cotugno and Monaldi Hospital, Napoli, Italy.
De Rosa R; Critical Area Department, Azienda Ospedaliera dei Colli-Cotugno and Monaldi Hospital, Napoli, Italy.
Atripaldi L; Department of Health Services, Azienda Ospedaliera dei Colli-Cotugno and Monaldi Hospital, Napoli, Italy.
D'Abbraccio M; Department of Infectious Diseases and Infectious Diseases Emergencies, Azienda Ospedaliera dei Colli-Cotugno Hospital, Napoli, Italy.
Curvietto M; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy.
Mallardo D; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy.
Celentano E; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy.
Grimaldi AM; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy.
Palla M; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy.
Trojaniello C; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy.
Vitale MG; Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy.
Million-Weaver SL; Independent Investigator, Madison, Wisconsin, USA.
Ascierto PA; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy .
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Źródło :
Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Aug; Vol. 8 (2).
Typ publikacji :
Journal Article
Journal Info :
Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Print Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
Biomarkers, Pharmacological/*blood
Coronavirus Infections/*drug therapy
Interleukin-6/*blood
Pneumonia, Viral/*drug therapy
Aged ; Antiviral Agents/therapeutic use ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Female ; Humans ; Italy ; Lymphocyte Count ; Male ; Middle Aged ; Neutrophils ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Receptors, Interleukin-6/antagonists & inhibitors ; Retrospective Studies ; Treatment Outcome
SCR Disease Name :
COVID-19
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19.
Autorzy :
Saha A; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India.
Sharma AR; Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea.
Bhattacharya M; Department of Zoology, Fakir Mohan University, Balasore, Odisha, India.
Sharma G; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Gangwon-do, South Korea.
Lee SS; Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea.
Chakraborty C; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India. Electronic address: .
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Źródło :
Archives of medical research [Arch Med Res] 2020 Aug; Vol. 51 (6), pp. 595-597. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Science Country of Publication: United States NLM ID: 9312706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5487 (Electronic) Linking ISSN: 01884409 NLM ISO Abbreviation: Arch. Med. Res. Subsets: MEDLINE
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
Coronavirus Infections/*drug therapy
Cytokine Release Syndrome/*drug therapy
Pneumonia, Viral/*drug therapy
Receptors, Interleukin-6/*antagonists & inhibitors
Betacoronavirus ; Humans ; Interleukin-6/immunology ; Pandemics ; Protein Binding ; Signal Transduction
SCR Disease Name :
COVID-19
SCR Protocol :
COVID-19 drug treatment
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Potential Role of Anti-interleukin (IL)-6 Drugs in the Treatment of COVID-19: Rationale, Clinical Evidence and Risks.
Autorzy :
Crisafulli S; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Policlinico Universitario 'G. Martino', Via Consolare Valeria 1, 98125, Messina, Italy.
Isgrò V; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Policlinico Universitario 'G. Martino', Via Consolare Valeria 1, 98125, Messina, Italy.
La Corte L; Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, Messina, Italy.
Atzeni F; Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, Messina, Italy.
Trifirò G; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Policlinico Universitario 'G. Martino', Via Consolare Valeria 1, 98125, Messina, Italy. .
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Źródło :
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy [BioDrugs] 2020 Aug; Vol. 34 (4), pp. 415-422.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9705305 Publication Model: Print Cited Medium: Internet ISSN: 1179-190X (Electronic) Linking ISSN: 11738804 NLM ISO Abbreviation: BioDrugs Subsets: MEDLINE
MeSH Terms :
Coronavirus Infections/*therapy
Interleukin-6/*antagonists & inhibitors
Pneumonia, Viral/*therapy
Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Coronavirus Infections/metabolism ; Coronavirus Infections/pathology ; Humans ; Pandemics ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/pathology ; Receptors, Interleukin-6/antagonists & inhibitors ; Risk Assessment ; Safety
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Interleukin-6 and severe COVID-19: a systematic review and meta-analysis.
Autorzy :
Mojtabavi H; Universal Scientific Education and Research Network (USERN), Systematic Review and Meta-Analysis Expert Group (SRMEG), Tehran, Iran, Tehran University of Medical Sciences, Children's Medical Center, Research Center for Immunodeficiencies, Tehran, Iran.
Saghazadeh A; Universal Scientific Education and Research Network (USERN), Systematic Review and Meta-Analysis Expert Group (SRMEG), Tehran, Iran, Tehran University of Medical Sciences, Children's Medical Center, Research Center for Immunodeficiencies, Tehran, Iran.
Rezaei N; Tehran University of Medical Sciences, Children's Medical Center, Research Center for Immunodeficiencies, Tehran, Iran, Tehran University of Medical Sciences, School of Medicine, Department of Immunology, Tehran, Iran, Universal Scientific Education and Research Network (USERN), Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Tehran, Iran.
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Źródło :
European cytokine network [Eur Cytokine Netw] 2020 Jun 01; Vol. 31 (2), pp. 44-49.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
Journal Info :
Publisher: John Libbey Eurotext Ltd Country of Publication: France NLM ID: 9100879 Publication Model: Print Cited Medium: Internet ISSN: 1952-4005 (Electronic) Linking ISSN: 11485493 Subsets: MEDLINE
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Antibodies, Monoclonal, Humanized/*administration & dosage
Antiviral Agents/*therapeutic use
Betacoronavirus/*immunology
Coronavirus Infections/*drug therapy
Cytokine Release Syndrome/*drug therapy
Interleukin-6/*antagonists & inhibitors
Pneumonia, Viral/*drug therapy
Aged ; Betacoronavirus/pathogenicity ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Coronavirus Infections/virology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/mortality ; Cytokine Release Syndrome/virology ; Female ; Gene Expression ; Humans ; Intensive Care Units ; Interleukin-6/genetics ; Interleukin-6/immunology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/immunology ; Severity of Illness Index ; Survival Analysis ; Treatment Outcome
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications.
Autorzy :
Smetana K Jr; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic .; BIOCEV, Vestec, Czech Republic.
Brábek J; BIOCEV, Vestec, Czech Republic .; Department of Cell Biology, Faculty of Sciences, Charles University, Prague, Czech Republic.
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Źródło :
In vivo (Athens, Greece) [In Vivo] 2020 Jun; Vol. 34 (3 Suppl), pp. 1589-1592.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Dr. J.G. Delinassios Country of Publication: Greece NLM ID: 8806809 Publication Model: Print Cited Medium: Internet ISSN: 1791-7549 (Electronic) Linking ISSN: 0258851X NLM ISO Abbreviation: In Vivo Subsets: MEDLINE
MeSH Terms :
Coronavirus Infections/*complications
Cytokine Release Syndrome/*etiology
Interleukin-6/*physiology
Pneumonia, Viral/*complications
Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Cytokine Receptor gp130/antagonists & inhibitors ; Cytokine Receptor gp130/physiology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/physiopathology ; Humans ; Immunotherapy ; Indoles/therapeutic use ; Interleukin-6/antagonists & inhibitors ; Lung/pathology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/physiology ; Receptors, Virus/drug effects ; Signal Transduction
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
The differential response to anti IL-6 treatment in COVID-19: the genetic counterpart.
Autorzy :
Perricone C; Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Conigliaro P; Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Ciccacci C; UniCamillus, Saint Camillus International University of Health Sciences, Rome, and Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
Marcucci E; Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Cafaro G; Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Bartoloni E; Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Perricone R; Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Novelli G; Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
Borgiani P; Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
Gerli R; Rheumatology Unit, Department of Medicine, University of Perugia, Italy. .
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Źródło :
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2020 May-Jun; Vol. 38 (3), pp. 580. Date of Electronic Publication: 2020 May 10.
Typ publikacji :
Letter
Journal Info :
Publisher: Clinical And Experimental Rheumatology S.A.S Country of Publication: Italy NLM ID: 8308521 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0392-856X (Print) Linking ISSN: 0392856X NLM ISO Abbreviation: Clin. Exp. Rheumatol. Subsets: MEDLINE
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Coronavirus Infections/*drug therapy
Coronavirus Infections/*genetics
Interleukin-6/*antagonists & inhibitors
Pneumonia, Viral/*drug therapy
Pneumonia, Viral/*genetics
Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antigens, CD/genetics ; Antigens, Differentiation, T-Lymphocyte/genetics ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Betacoronavirus ; Humans ; Lectins, C-Type/genetics ; Middle Aged ; Pandemics ; Polymorphism, Single Nucleotide ; Receptors, Interleukin-6/genetics
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Opinia redakcyjna
Tytuł :
Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts.
Autorzy :
Omiya S; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Omori Y; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Taneike M; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Murakawa T; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Ito J; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Tanada Y; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Nishida K; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Yamaguchi O; Department of Cardiovascular Medicine, Graduate School of Medicine (O.Y.), Osaka University, Suita, Japan.
Satoh T; Laboratory of Host Defense, Research Institute for Microbial Diseases (T.S., S.A.), Osaka University, Suita, Japan.
Shah AM; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
Akira S; Laboratory of Host Defense, Research Institute for Microbial Diseases (T.S., S.A.), Osaka University, Suita, Japan.
Otsu K; The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, United Kingdom (S.O., Y.O., M.T., T.M., J.I., Y.T., K.N., A.M.S., K.O.).
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Źródło :
Circulation [Circulation] 2020 Feb 25; Vol. 141 (8), pp. 667-677. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Inflammation/*pathology
Interleukin-6/*metabolism
Myocytes, Cardiac/*metabolism
RNA, Messenger/*metabolism
Ribonucleases/*genetics
Animals ; Antibodies/immunology ; Antibodies/therapeutic use ; Cardiomyopathy, Dilated/etiology ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Genetic Vectors/metabolism ; Heart Failure/etiology ; Heart Failure/prevention & control ; Inflammation/prevention & control ; Interleukin-6/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Interleukin-6/immunology ; Ribonucleases/deficiency ; Ribonucleases/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors.
Autorzy :
Alfinito E; Department for Innovation Engineering, University of Salento, Piazza Tancredi, I-73100 Lecce, Italy.
Beccaria M; Department of Mathematics and Physics 'Ennio de Giorgi', University of Salento, Piazza Tancredi, I-73100 Lecce, Italy.; National Institute for Nuclear Physics, I.N.F.N, Lecce Unit, I-73100 Lecce, Italy.
Ciccarese M; Oncology Unit 'Vito Fazzi' Hospital-Lecce, I-73100 Lecce, Italy.
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Źródło :
Biosensors [Biosensors (Basel)] 2020 Aug 24; Vol. 10 (9). Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Comparative Study; Journal Article
Journal Info :
Publisher: MDPI Pub Country of Publication: Switzerland NLM ID: 101609191 Publication Model: Electronic Cited Medium: Internet ISSN: 2079-6374 (Electronic) Linking ISSN: 20796374 NLM ISO Abbreviation: Biosensors (Basel) Subsets: MEDLINE
MeSH Terms :
Biosensing Techniques/*methods
Interleukin-6/*analysis
Receptors, Interleukin-6/*analysis
Antibodies, Monoclonal/analysis ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal, Humanized/chemistry ; Antibodies, Monoclonal, Humanized/immunology ; Aptamers, Nucleotide/chemistry ; Betacoronavirus/isolation & purification ; Coronavirus Infections/diagnosis ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Humans ; Immunoglobulin Fab Fragments/analysis ; Immunoglobulin Fab Fragments/immunology ; Interleukin-6/immunology ; Limit of Detection ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Receptors, Interleukin-6/immunology
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics.
Autorzy :
Abbasifard M; Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Internal Medicine, Ali-Ibn-Abi-talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Khorramdelazad H; Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118097. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Betacoronavirus/*immunology
Coronavirus Infections/*immunology
Interleukin-6/*immunology
Pneumonia, Viral/*immunology
Betacoronavirus/metabolism ; Coronavirus Infections/metabolism ; Cytokines/immunology ; Humans ; Inflammation/immunology ; Interleukin-6/metabolism ; Interleukin-6/pharmacology ; Middle East Respiratory Syndrome Coronavirus/immunology ; Pandemics ; Pneumonia, Viral/metabolism ; SARS Virus/immunology
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Effect of NMO-IgG on the interleukin-6 cascade in astrocytes via activation of the JAK/STAT3 signaling pathway.
Autorzy :
Du L; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Chang H; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Xu W; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Wei Y; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Wang Y; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Yin L; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China. Electronic address: .
Zhang X; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118217. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Astrocytes/*metabolism
Immunoglobulin G/*blood
Interleukin-6/*metabolism
Janus Kinases/*metabolism
Neuromyelitis Optica/*blood
STAT3 Transcription Factor/*metabolism
Adult ; Aged ; Animals ; Astrocytes/drug effects ; Autoantibodies/blood ; Autoantibodies/pharmacology ; Cells, Cultured ; Female ; Humans ; Immunoglobulin G/pharmacology ; Interleukin-6/agonists ; Male ; Middle Aged ; Rats ; Rats, Wistar ; STAT3 Transcription Factor/agonists ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Young Adult
Czasopismo naukowe
Tytuł :
Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation.
Autorzy :
Paniri A; Student Research Committee, Babol University of Medical Sciences, Babol, Iran; Genetics Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Akhavan-Niaki H; Genetics Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran; Zoonoses Research Center, Pasteur Institute of Iran, Amol, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118114. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
Betacoronavirus/*genetics
Coronavirus Infections/*immunology
Interleukin-6/*immunology
Pneumonia, Viral/*immunology
RNA, Long Noncoding/*physiology
Anti-Inflammatory Agents/pharmacology ; Betacoronavirus/immunology ; Betacoronavirus/metabolism ; Coronavirus Infections/metabolism ; Cytokines/genetics ; Cytokines/immunology ; Humans ; Inflammasomes/immunology ; Inflammation/immunology ; Interleukin-6/metabolism ; Interleukin-6/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Pandemics ; Pneumonia, Viral/metabolism ; RNA, Long Noncoding/genetics
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6.
Autorzy :
Cazzolla AP; Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.
Lovero R; AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.
Lo Muzio L; Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.
Testa NF; Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.
Schirinzi A; AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.
Palmieri G; Private practice, Bari 70124, Italy.
Pozzessere P; AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Emergency Medicine and Surgery Unit, Bari 70124, Italy.
Procacci V; AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Emergency Medicine and Surgery Unit, Bari 70124, Italy.
Di Comite M; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Human Anatomy Section, Università degli Studi di Bari, Bari 70124, Italy.
Ciavarella D; Department of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia 71122, Italy.
Pepe M; AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.
De Ruvo C; Maugeri Clinical Research Institutes IRCCS of Bari, Bari 70124, Italy.
Crincoli V; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Human Anatomy Section, Università degli Studi di Bari, Bari 70124, Italy.
Di Serio F; AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Clinical Pathology Unit, Bari 70124, Italy.
Santacroce L; Ionian Department (DJSGEM), Microbiology and Virology Lab, Università degli Studi di Bari, Bari 70124, Italy.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2020 Sep 02; Vol. 11 (17), pp. 2774-2781. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Observational Study
Journal Info :
Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
MeSH Terms :
Betacoronavirus*
Coronavirus Infections/*blood
Interleukin-6/*blood
Olfaction Disorders/*blood
Pneumonia, Viral/*blood
Taste Disorders/*blood
Aged ; Aged, 80 and over ; Biomarkers/blood ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Female ; Health Surveys/methods ; Humans ; Interleukin-6/physiology ; Male ; Middle Aged ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Taste/physiology ; Taste Disorders/diagnosis ; Taste Disorders/etiology
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Interleukin-6: A Masterplayer in the Cytokine Network.
Autorzy :
Uciechowski P; Institute of Immunology, Medical Faculty, RWTH, Aachen, Germany.
Dempke WCM; University of Munich, Medical Faculty, Munich, Germany, .
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Źródło :
Oncology [Oncology] 2020; Vol. 98 (3), pp. 131-137. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Karger Country of Publication: Switzerland NLM ID: 0135054 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0232 (Electronic) Linking ISSN: 00302414 NLM ISO Abbreviation: Oncology Subsets: MEDLINE
MeSH Terms :
Signal Transduction*
Inflammation/*metabolism
Inflammation Mediators/*metabolism
Interleukin-6/*metabolism
Anti-Inflammatory Agents/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/enzymology ; Inflammation Mediators/antagonists & inhibitors ; Interleukin-6/antagonists & inhibitors ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinases/antagonists & inhibitors ; Janus Kinases/metabolism ; Molecular Targeted Therapy ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/metabolism ; STAT Transcription Factors/antagonists & inhibitors ; STAT Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
A benefit and the prospects of IL-6 inhibitors in idiopathic multicentric Castleman's disease.
Autorzy :
Koga T; a Unit of Advanced Preventive Medical Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.; b Center for Bioinformatics and Molecular Medicine , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Sumiyoshi R; a Unit of Advanced Preventive Medical Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Kawakami A; a Unit of Advanced Preventive Medical Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Yoshizaki K; c Department of Biomolecular Science and Regulation , The Institute of Scientific and Industrial Research, Osaka University , Osaka , Japan.
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Źródło :
Modern rheumatology [Mod Rheumatol] 2019 Mar; Vol. 29 (2), pp. 302-305. Date of Electronic Publication: 2019 Jan 14.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 100959226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7609 (Electronic) Linking ISSN: 14397595 NLM ISO Abbreviation: Mod Rheumatol Subsets: MEDLINE
MeSH Terms :
Castleman Disease*/diagnosis
Castleman Disease*/immunology
Castleman Disease*/therapy
Interleukin-6*/antagonists & inhibitors
Interleukin-6*/blood
Antibodies, Monoclonal, Humanized/*pharmacology
Glucocorticoids/*pharmacology
Antibodies/blood ; Herpesvirus 8, Human/immunology ; Humans ; Immunologic Factors/pharmacology ; Japan ; Prognosis ; Receptors, Interleukin-6/immunology ; Treatment Outcome
SCR Disease Name :
Multi-centric Castleman's Disease
Czasopismo naukowe
Tytuł :
Inhibition of interleukin-6 on matrix protein production by glomerular mesangial cells and the pathway involved.
Autorzy :
Chaudhari S; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Yazdizadeh Shotorbani P; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Tao Y; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Davis ME; Chemical Engineering, California Institute of Technology, Pasadena, California.
Mallet RT; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Ma R; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Jun 01; Vol. 318 (6), pp. F1478-F1488. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE
MeSH Terms :
Extracellular Matrix Proteins/*metabolism
Interleukin-6/*metabolism
Mesangial Cells/*metabolism
Receptors, Interleukin-6/*metabolism
Animals ; Cells, Cultured ; Down-Regulation ; Extracellular Matrix Proteins/genetics ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucagon-Like Peptide-1 Receptor/metabolism ; Humans ; Interleukin-6/genetics ; Male ; Mice, Inbred C57BL ; NF-kappa B/genetics ; NF-kappa B/metabolism ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism ; Receptors, Interleukin-6/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
EBV Rta-induced IL-6 Promotes Migration of Bystander Tumor Cells Through IL-6R/JAK/STAT3 Pathway In Vitro .
Autorzy :
Tung KL; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Wu YT; Department of Pathology, Golden Hospital, Pingtung, Taiwan, R.O.C.
Liu C; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.; Department of Health and Beauty, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Lin SC; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Wu CH; Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
Wu SY; Department of Pathology, Golden Hospital, Pingtung, Taiwan, R.O.C.
Chang Y; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan, R.O.C.
Lan YY; Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C. .
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Źródło :
Anticancer research [Anticancer Res] 2020 Jun; Vol. 40 (6), pp. 3255-3264.
Typ publikacji :
Journal Article
Journal Info :
Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res. Subsets: MEDLINE
MeSH Terms :
Immediate-Early Proteins/*metabolism
Interleukin-6/*metabolism
Janus Kinases/*metabolism
Neoplasms/*metabolism
Receptors, Interleukin-6/*metabolism
STAT3 Transcription Factor/*metabolism
Trans-Activators/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/virology ; Cell Line, Tumor ; Cell Movement/physiology ; Humans ; Immediate-Early Proteins/genetics ; Interleukin-6/biosynthesis ; Interleukin-6/genetics ; MAP Kinase Signaling System ; MCF-7 Cells ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/metabolism ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Carcinoma/virology ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/metabolism ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/virology ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/virology ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Stomach Neoplasms/virology ; Trans-Activators/genetics ; Transcription Factor AP-1/metabolism ; Transfection ; Up-Regulation
Czasopismo naukowe
Tytuł :
Interleukin 6 levels after tocilizumab administration in transplant recipients with COVID-19.
Autorzy :
Gade AR; Internal Medicine Residency Program, Department of Medicine, Medical City Fort Worth, Fort Worth, Texas, USA.
Alavala H; Division of Transplant Nephrology, Tarrant Nephrology Associates/Premier Physicians Group Health, Fort Worth, Texas, USA.
Allam SR; Division of Transplant Nephrology, Tarrant Nephrology Associates/Premier Physicians Group Health, Fort Worth, Texas, USA. Electronic address: .
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Źródło :
Kidney international [Kidney Int] 2020 Oct; Vol. 98 (4), pp. 1054. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Letter; Comment
Journal Info :
Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE
MeSH Terms :
Coronavirus Infections*
Interleukin-6*
Kidney Transplantation*
Pandemics*
Pneumonia, Viral*
Antibodies, Monoclonal, Humanized ; Betacoronavirus ; Cytokine Release Syndrome ; Humans ; Transplant Recipients
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Opinia redakcyjna

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