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Tytuł :
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome.
Autorzy :
Kang S; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Tanaka T; Medical Affairs Bureau, Osaka Habikino Medical Center, Osaka 583-8588, Japan.
Inoue H; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Ono C; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Hashimoto S; Department of Clinical Laboratory, Osaka Habikino Medical Center, Osaka 583-8588, Japan.
Kioi Y; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Matsumoto H; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Matsuura H; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Matsubara T; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Shimizu K; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Ogura H; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Matsuura Y; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Kishimoto T; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22351-22356. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Cytokine Release Syndrome/*metabolism
Endothelial Cells/*metabolism
Interleukin-6/*metabolism
Plasminogen Activator Inhibitor 1/*metabolism
Adult ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Betacoronavirus ; Burns/metabolism ; Burns/pathology ; Cells, Cultured ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Coronavirus Infections/pathology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/pathology ; Cytokines/blood ; Cytokines/metabolism ; Endothelial Cells/drug effects ; Female ; Humans ; Inflammation ; Interleukin-6/blood ; Male ; Middle Aged ; Pandemics ; Plasminogen Activator Inhibitor 1/blood ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/pathology ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/metabolism ; Respiratory Distress Syndrome, Adult/metabolism ; Respiratory Distress Syndrome, Adult/pathology ; Sepsis/metabolism ; Sepsis/pathology
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling.
Autorzy :
Higuchi Y; Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8501, Japan.; Department of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Yasunaga JI; Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8501, Japan; .; Department of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Mitagami Y; Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Tsukamoto H; Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Nakashima K; Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830-0011, Japan.
Ohshima K; Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830-0011, Japan.
Matsuoka M; Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8501, Japan.; Department of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 16; Vol. 117 (24), pp. 13740-13749. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic-Leucine Zipper Transcription Factors/*immunology
HTLV-I Infections/*immunology
Human T-lymphotropic virus 1/*immunology
Interleukin-6/*immunology
Lymphoma/*virology
Retroviridae Proteins/*immunology
Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Cell Differentiation ; Cell Proliferation ; HTLV-I Infections/genetics ; HTLV-I Infections/pathology ; HTLV-I Infections/virology ; Host-Pathogen Interactions ; Human T-lymphotropic virus 1/genetics ; Human T-lymphotropic virus 1/physiology ; Humans ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukin-6/genetics ; Lymphoma/genetics ; Lymphoma/immunology ; Lymphoma/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Retroviridae Proteins/genetics ; T-Lymphocytes, Regulatory/immunology
Czasopismo naukowe
Tytuł :
Regulation of adipose tissue inflammation by interleukin 6.
Autorzy :
Han MS; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
White A; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
Perry RJ; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
Camporez JP; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
Hidalgo J; Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autonoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
Davis RJ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 11; Vol. 117 (6), pp. 2751-2760. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue/*immunology
Interleukin-6/*immunology
Obesity/*immunology
ADAM10 Protein/genetics ; ADAM10 Protein/immunology ; ADAM17 Protein/genetics ; ADAM17 Protein/immunology ; Adipocytes/immunology ; Animals ; Female ; Humans ; Interleukin-6/genetics ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Cells/immunology ; Myeloid Cells/immunology ; Obesity/genetics ; Species Specificity
Czasopismo naukowe
Tytuł :
Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines.
Autorzy :
Rao L; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.
Xia S; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China.
Xu W; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China.
Tian R; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.
Yu G; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.
Gu C; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China.
Pan P; Institute of Medical Microbiology, Jinan University, 510632 Guangzhou, China.; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 430072 Wuhan, China.
Meng QF; School of Physics and Technology, Wuhan University, 430072 Wuhan, China.
Cai X; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China.
Qu D; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China.
Lu L; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China; .
Xie Y; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China; .
Jiang S; Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China; .
Chen X; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 03; Vol. 117 (44), pp. 27141-27147. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Infections/*therapy
Cytokines/*antagonists & inhibitors
Nanoparticles/*therapeutic use
Pneumonia, Viral/*therapy
Virus Internalization/*drug effects
Animals ; Betacoronavirus ; Cell Membrane/chemistry ; Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; HEK293 Cells ; Humans ; Interleukin-6/antagonists & inhibitors ; Mice ; Mice, Inbred ICR ; Monocytes ; Nanoparticles/chemistry ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Receptors, Cytokine/metabolism ; THP-1 Cells
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
Autorzy :
Khatib A; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Solaimuthu B; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Ben Yosef M; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Abu Rmaileh A; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Tanna M; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Oren G; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Schlesinger Frisch M; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Axelrod JH; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, 91120 Jerusalem, Israel.
Lichtenstein M; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Shaul YD; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 01; Vol. 117 (35), pp. 21420-21431. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*enzymology
Interleukin-6/*metabolism
Janus Kinases/*metabolism
Peroxidases/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Breast Neoplasms/mortality ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Female ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Phenotype ; Signal Transduction
Czasopismo naukowe
Tytuł :
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression.
Autorzy :
Crawford MP; Department of Pathology, University of Iowa Health Care, Iowa City, IA 52242.
Sinha S; Department of Pathology, University of Iowa Health Care, Iowa City, IA 52242.
Renavikar PS; Department of Pathology, University of Iowa Health Care, Iowa City, IA 52242.
Borcherding N; Department of Pathology, University of Iowa Health Care, Iowa City, IA 52242.
Karandikar NJ; Department of Pathology, University of Iowa Health Care, Iowa City, IA 52242 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 19408-19414. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
Immune Tolerance/*immunology
Interleukin-17/*immunology
Th17 Cells/*immunology
CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Humans ; Interleukin-17/metabolism ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; T-Lymphocyte Subsets/immunology
Czasopismo naukowe
Tytuł :
TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection.
Autorzy :
Tuazon Kels MJ; Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Ng E; Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Al Rumaih Z; Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Pandey P; Viral Immunology and Immunopathology Group, Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
Ruuls SR; Genmab, 3584 CT Utrecht, The Netherlands.
Korner H; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Newsome TP; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Chaudhri G; Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.; Research School of Population Health, Australian National University, Canberra, ACT 2601, Australia.
Karupiah G; Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia; .; Viral Immunology and Immunopathology Group, Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 07; Vol. 117 (27), pp. 15935-15946. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokines/*metabolism
Poxviridae/*metabolism
Poxviridae Infections/*virology
Tumor Necrosis Factor-alpha/*genetics
Tumor Necrosis Factor-alpha/*metabolism
Animals ; Cell Line, Tumor ; Female ; Interferon-gamma/metabolism ; Interleukin-10/metabolism ; Interleukin-6/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Poxviridae/immunology ; Poxviridae Infections/immunology ; Poxviridae Infections/pathology ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/virology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.
Autorzy :
Mikami N; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Yamadaoka, 565-0871 Suita, Osaka, Japan.; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, 606-8507 Kyoto, Japan.
Kawakami R; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Yamadaoka, 565-0871 Suita, Osaka, Japan.; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, 606-8507 Kyoto, Japan.
Chen KY; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Yamadaoka, 565-0871 Suita, Osaka, Japan.
Sugimoto A; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Yamadaoka, 565-0871 Suita, Osaka, Japan.
Ohkura N; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Yamadaoka, 565-0871 Suita, Osaka, Japan.
Sakaguchi S; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Yamadaoka, 565-0871 Suita, Osaka, Japan; .; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, 606-8507 Kyoto, Japan.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 02; Vol. 117 (22), pp. 12258-12268. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Epigenesis, Genetic*
Gene Expression Regulation*
CD28 Antigens/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Forkhead Transcription Factors/*physiology
T-Lymphocytes, Regulatory/*immunology
Animals ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation ; Cytokines/metabolism ; Female ; Interleukin-6/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Signal Transduction ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Effective treatment of severe COVID-19 patients with tocilizumab.
Autorzy :
Xu X; Respiratory and Critical Care Medicine, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People's Republic of China; .
Han M; Respiratory and Critical Care Medicine, Anhui Fuyang Second People's Hospital, Fuyang, Anhui 230000, People's Republic of China.
Li T; Respiratory and Critical Care Medicine, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People's Republic of China.
Sun W; Respiratory and Critical Care Medicine, Anhui Fuyang Second People's Hospital, Fuyang, Anhui 230000, People's Republic of China.
Wang D; Respiratory and Critical Care Medicine, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People's Republic of China.
Fu B; Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China.; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China.
Zhou Y; Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China.; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China.
Zheng X; Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China.; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China.
Yang Y; Intensive Care Unit, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People's Republic of China.
Li X; Hemodialysis Center, Anhui Fuyang Second People's Hospital, Fuyang, Anhui 236000, People's Republic of China.
Zhang X; Respiratory and Critical Care Medicine, Anhui Fuyang Second People's Hospital, Fuyang, Anhui 230000, People's Republic of China.
Pan A; Intensive Care Unit, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People's Republic of China.
Wei H; Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China; .; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People's Republic of China.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 19; Vol. 117 (20), pp. 10970-10975. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus*
Antibodies, Monoclonal, Humanized/*administration & dosage
Coronavirus Infections/*drug therapy
Pneumonia, Viral/*drug therapy
Adult ; Aged ; Aged, 80 and over ; China ; Coronavirus Infections/blood ; Coronavirus Infections/physiopathology ; Disease Progression ; Female ; Humans ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/blood ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/physiopathology ; Treatment Outcome
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells.
Autorzy :
Püschel F; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Favaro F; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.; Department of Experimental Immunology, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Lymphoma and Myeloma Center, Cancer Center Amsterdam, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Institute for Infection & Immunity, 1105 AZ Amsterdam, The Netherlands.
Redondo-Pedraza J; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Lucendo E; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Iurlaro R; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Marchetti S; INSERM, Centre Méditerranéen de Médecine Moléculaire, Université Côte d'Azur, 06204 Nice, France.
Majem B; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain.
Eldering E; Department of Experimental Immunology, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Lymphoma and Myeloma Center, Cancer Center Amsterdam, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Institute for Infection & Immunity, 1105 AZ Amsterdam, The Netherlands.
Nadal E; Thoracic Oncology Unit, Department of Medical Oncology, Catalan Institute of Oncology, Hospitalet, 08908 Barcelona, Spain.
Ricci JE; INSERM, Centre Méditerranéen de Médecine Moléculaire, Université Côte d'Azur, 06204 Nice, France.
Chevet E; INSERM U1242 'Chemistry, Oncogenesis, Stress, Signaling,' Université de Rennes, 35042 Rennes, France.; INSERM U1242, Centre de Lutte Contre le Cancer Eugène Marquis, 35042 Rennes, France.
Muñoz-Pinedo C; Oncobell Program, Bellvitge Biomedical Research Institute, Hospitalet, 08908 Barcelona, Spain; .; Department of Basic Nursing, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Hospitalet, 08907 Barcelona, Spain.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 05; Vol. 117 (18), pp. 9932-9941. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*genetics
Interleukin-6/*genetics
Interleukin-8/*genetics
Neoplasms/*metabolism
Stress, Physiological/*genetics
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Antimetabolites/pharmacology ; Cell Death/drug effects ; Deoxyglucose/pharmacology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Glucose/metabolism ; Glutamine/metabolism ; HeLa Cells ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Metformin/pharmacology ; NF-kappa B/genetics ; Neoplasms/genetics ; Promoter Regions, Genetic/genetics ; Starvation/genetics ; Starvation/metabolism ; Stress, Physiological/immunology
Czasopismo naukowe
Tytuł :
CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.
Autorzy :
Slowikowski K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115.
Nguyen HN; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Noss EH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Simmons DP; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Mizoguchi F; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8519 Tokyo, Japan.
Watts GFM; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Gurish MF; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; .
Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; .; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115.; Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health Science Centre, University of Manchester, M13 9PL Manchester, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 10; Vol. 117 (10), pp. 5532-5541. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Arthritis, Rheumatoid/*metabolism
Fibroblasts/*metabolism
Homeodomain Proteins/*metabolism
Inflammation/*metabolism
Interleukin-17/*physiology
Repressor Proteins/*metabolism
Transcription Factors/*metabolism
Transcriptome/*physiology
Tumor Necrosis Factor-alpha/*physiology
Adaptor Proteins, Signal Transducing/genetics ; Arthritis, Rheumatoid/genetics ; Cells, Cultured ; Chemokine CXCL1/genetics ; Chemokine CXCL2/genetics ; Chemokines, CXC/genetics ; Chemotactic Factors/genetics ; Fibroblasts/drug effects ; Homeodomain Proteins/genetics ; Humans ; Inflammation/genetics ; Interleukin-17/pharmacology ; Interleukin-6/genetics ; Matrix Metalloproteinase 3/metabolism ; Monocytes/drug effects ; Monocytes/physiology ; RNA, Small Interfering/genetics ; Repressor Proteins/genetics ; Stromal Cells/drug effects ; Stromal Cells/metabolism ; Synovial Fluid ; Transcription Factor RelA/metabolism ; Transcription Factors/genetics ; Transcriptome/radiation effects ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination.
Autorzy :
Houben E; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Janssens K; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Hermans D; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Vandooren J; Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.
Van den Haute C; Department of Neurosciences, Laboratory for Neurobiology and Gene Therapy, KU Leuven, 3000 Leuven, Belgium.; Leuven Viral Vector Core, KU Leuven, 3000 Leuven, Belgium.
Schepers M; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.; School for Mental Health and Neuroscience, Division Translational Neuroscience, Maastricht University, 6200MD Maastricht, The Netherlands.
Vanmierlo T; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.; School for Mental Health and Neuroscience, Division Translational Neuroscience, Maastricht University, 6200MD Maastricht, The Netherlands.
Lambrichts I; Department of Morphology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
van Horssen J; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.; Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam University Medical Center, location Vrije Universiteit (VU) University Medical Center, Multiple Sclerose Centrum, 1007 MB Amsterdam, The Netherlands.
Baekelandt V; Department of Neurosciences, Laboratory for Neurobiology and Gene Therapy, KU Leuven, 3000 Leuven, Belgium.
Opdenakker G; Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.
Baron W; Section Molecular Neurobiology, Department Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands.
Broux B; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Slaets H; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Hellings N; Department of Immunology, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 03; Vol. 117 (9), pp. 5028-5038. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Oncostatin M/*metabolism
Remyelination/*physiology
Tissue Inhibitor of Metalloproteinase-1/*metabolism
Animals ; Astrocytes/pathology ; Axons ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Demyelinating Diseases/metabolism ; Demyelinating Diseases/pathology ; Humans ; Interleukin-6/metabolism ; Mice ; Mice, Knockout ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Myelin Sheath ; Oligodendrocyte Precursor Cells ; Tissue Inhibitor of Metalloproteinase-1/genetics
Czasopismo naukowe
Tytuł :
IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression.
Autorzy :
Nan J; Institute of Cancer Biology and Drug Screening, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Wang Y; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Yang J; Institute of Cancer Biology and Drug Screening, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China; .; Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao, Shandong 266000, China.
Stark GR; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Apr 10; Vol. 115 (15), pp. 3906-3911. Date of Electronic Publication: 2018 Mar 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon-Stimulated Gene Factor 3, gamma Subunit/*metabolism
Interleukin-6/*genetics
NF-kappa B/*metabolism
STAT2 Transcription Factor/*metabolism
Gene Expression Regulation ; Humans ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Interleukin-6/metabolism ; NF-kappa B/genetics ; Phosphorylation ; Promoter Regions, Genetic ; Response Elements ; STAT2 Transcription Factor/genetics ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.
Autorzy :
Ashouri JF; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143.
Hsu LY; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143.
Yu S; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143.
Rychkov D; Institute for Computational Health Sciences, University of California, San Francisco, CA 94143.; Department of Pediatrics, University of California, San Francisco, CA 94143.
Chen Y; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143.
Cheng DA; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143.
Sirota M; Institute for Computational Health Sciences, University of California, San Francisco, CA 94143.; Department of Pediatrics, University of California, San Francisco, CA 94143.
Hansen E; Department of Orthopedic Surgery, University of California, San Francisco, CA 94143.
Lattanza L; Department of Orthopedic Surgery, University of California, San Francisco, CA 94143.
Zikherman J; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143.
Weiss A; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143; .; Howard Hughes Medical Institute, University of California, San Francisco, CA 94143.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 10; Vol. 116 (37), pp. 18517-18527. Date of Electronic Publication: 2019 Aug 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Experimental/*immunology
Arthritis, Rheumatoid/*immunology
CD4-Positive T-Lymphocytes/*immunology
Synovial Membrane/*immunology
Th17 Cells/*immunology
Adult ; Aged ; Animals ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/surgery ; Biopsy ; CD4-Positive T-Lymphocytes/metabolism ; Cell Differentiation/immunology ; Down-Regulation ; Female ; Genes, Reporter/genetics ; Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Humans ; Interleukin-17/metabolism ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Nuclear Receptor Subfamily 4, Group A, Member 1/chemistry ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/immunology ; Suppressor of Cytokine Signaling 3 Protein/immunology ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Synovectomy ; Synovial Membrane/cytology ; Synovial Membrane/metabolism ; Synovial Membrane/pathology ; Th17 Cells/metabolism ; Zymosan/administration & dosage ; Zymosan/immunology
Czasopismo naukowe
Tytuł :
Mast cells are critical for controlling the bacterial burden and the healing of infected wounds.
Autorzy :
Zimmermann C; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Troeltzsch D; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Giménez-Rivera VA; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Galli SJ; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5176.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5176.
Metz M; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Maurer M; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Siebenhaar F; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Oct 08; Vol. 116 (41), pp. 20500-20504. Date of Electronic Publication: 2019 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Keratinocytes/*immunology
Mast Cells/*immunology
Pseudomonas Infections/*prevention & control
Pseudomonas aeruginosa/*immunology
Skin/*immunology
Wound Healing/*immunology
Wound Infection/*prevention & control
Animals ; Anti-Bacterial Agents/pharmacology ; Cells, Cultured ; Humans ; Interleukin-6/pharmacology ; Keratinocytes/drug effects ; Mast Cells/cytology ; Mice ; Pseudomonas Infections/immunology ; Pseudomonas Infections/microbiology ; Skin/drug effects ; Wound Healing/drug effects ; Wound Infection/immunology ; Wound Infection/microbiology
Czasopismo naukowe
Tytuł :
Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7 microRNA in macrophages.
Autorzy :
Jiang S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Yan W; Department of Pathology, University of California, San Diego, La Jolla, CA 92093.
Wang SE; Department of Pathology, University of California, San Diego, La Jolla, CA 92093.
Baltimore D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jun 18; Vol. 116 (25), pp. 12416-12421. Date of Electronic Publication: 2019 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Processing, Post-Translational*
DNA-Binding Proteins/*metabolism
Macrophages/*metabolism
MicroRNAs/*physiology
Proto-Oncogene Proteins/*metabolism
Animals ; Interleukin-6/biosynthesis ; Interleukin-6/genetics ; Lipopolysaccharides ; Macrophages/drug effects ; Macrophages/enzymology ; Mice ; Mice, Knockout ; RNA, Messenger/genetics ; Succinate Dehydrogenase/metabolism ; Succinates/metabolism
Czasopismo naukowe
Tytuł :
Treg-mediated prolonged survival of skin allografts without immunosuppression.
Autorzy :
Pilat N; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Wiletel M; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Weijler AM; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Steiner R; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Mahr B; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Warren J; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.
Corpuz TM; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.
Wekerle T; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Webster KE; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.
Sprent J; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; .; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 02; Vol. 116 (27), pp. 13508-13516. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Graft Survival*/immunology
Skin Transplantation*
Graft Rejection/*prevention & control
T-Lymphocytes, Regulatory/*immunology
Allografts ; Animals ; Antibodies, Monoclonal/immunology ; Female ; Flow Cytometry ; Immunosuppressive Agents/therapeutic use ; Interleukin-2/immunology ; Interleukin-6/antagonists & inhibitors ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Sirolimus/therapeutic use
Czasopismo naukowe
Tytuł :
Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types.
Autorzy :
Noss EH; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115 .
Nguyen HN; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
Chang SK; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
Watts GF; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
Brenner MB; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Dec 01; Vol. 112 (48), pp. 14948-53. Date of Electronic Publication: 2015 Nov 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Interleukin-6*/biosynthesis
Interleukin-6*/genetics
Polymorphism, Single Nucleotide*
Arthritis, Rheumatoid/*genetics
Arthritis, Rheumatoid/*metabolism
Fibroblasts/*metabolism
Arthritis, Rheumatoid/pathology ; Cells, Cultured ; Female ; Fibroblasts/pathology ; Humans ; Male ; RNA Stability/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
Mobile platform for rapid sub-picogram-per-milliliter, multiplexed, digital droplet detection of proteins.
Autorzy :
Yelleswarapu V; School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321.
Buser JR; Chip Diagnostics, Philadelphia, PA 19104.
Haber M; School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321.
Baron J; School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321.
Inapuri E; School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321.
Issadore D; School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321; .; Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104-6321.; Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104-6321.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Mar 05; Vol. 116 (10), pp. 4489-4495. Date of Electronic Publication: 2019 Feb 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Microfluidic Analytical Techniques*
Point-of-Care Systems*
Granulocyte-Macrophage Colony-Stimulating Factor/*blood
Interleukin-6/*blood
Enzyme-Linked Immunosorbent Assay ; Humans
Czasopismo naukowe
Tytuł :
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.
Autorzy :
Hashimoto-Kataoka T; Departments of Cardiovascular Medicine.
Hosen N; Cancer Stem Cell Biology Functional Diagnostic Science.
Sonobe T; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, 565-8565, Japan;
Arita Y; Departments of Cardiovascular Medicine.
Yasui T; Departments of Cardiovascular Medicine.
Masaki T; Departments of Cardiovascular Medicine.
Minami M; General Thoracic Surgery.
Inagaki T; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, 565-8565, Japan;
Miyagawa S; Cardiovascular Surgery, and.
Sawa Y; Cardiovascular Surgery, and.
Murakami M; Department of Molecular Neuroimmunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, 060-0815, Japan;
Kumanogoh A; Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan;
Yamauchi-Takihara K; Departments of Cardiovascular Medicine.
Okumura M; General Thoracic Surgery.
Kishimoto T; Laboratory of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka, 565-0871, Japan;
Komuro I; Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, 113-8656, Japan; and Core Research for Evolutional Science and Technology and.
Shirai M; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, 565-8565, Japan;
Sakata Y; Departments of Cardiovascular Medicine.
Nakaoka Y; Departments of Cardiovascular Medicine, Precursory Research for Embryonic Science and Technology, Japan Science Technology Agency, Kawaguchi, Saitama, 332-0012, Japan .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 May 19; Vol. 112 (20), pp. E2677-86. Date of Electronic Publication: 2015 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypertension, Pulmonary/*physiopathology
Interleukin-6/*metabolism
Interleukins/*metabolism
Signal Transduction/*physiology
Vascular Remodeling/*physiology
Analysis of Variance ; Animals ; Antibodies, Monoclonal/immunology ; Blood Pressure ; Blotting, Western ; Body Weights and Measures ; DNA Primers/genetics ; Flow Cytometry ; Humans ; Immunohistochemistry ; Interleukin-6/blood ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Real-Time Polymerase Chain Reaction ; Receptors, Interleukin-21/deficiency
Czasopismo naukowe

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