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Wyszukujesz frazę ""Interleukin-6"" wg kryterium: Temat


Tytuł :
Genome-wide gene expression analysis of a murine model of prostate cancer progression: Deciphering the roles of IL-6 and p38 MAPK as potential therapeutic targets.
Autorzy :
Daouk R; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Bahmad HF; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, United States of America.; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.
Saleh E; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Monzer A; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Ballout F; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Kadara H; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Abou-Kheir W; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
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Źródło :
PloS one [PLoS One] 2020 Aug 13; Vol. 15 (8), pp. e0237442. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic/*drug effects
Imidazoles/*pharmacology
Interleukin-6/*pharmacology
Prostatic Neoplasms/*pathology
Pyridines/*pharmacology
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Androgens/metabolism ; Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Disease Models, Animal ; Disease Progression ; Epithelial-Mesenchymal Transition/drug effects ; Gene Regulatory Networks/genetics ; Imidazoles/therapeutic use ; Interleukin-6/therapeutic use ; Male ; Mice ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Pyridines/therapeutic use ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood.
Autorzy :
Ng SM; The Department of Social Work and Social Administration, The University of Hong Kong, sai wan, Hong Kong.
Leng LL; The Department of Social Work and Social Administration, The University of Hong Kong, sai wan, Hong Kong.
Xie QW; The Department of Social Work and Social Administration, The University of Hong Kong, sai wan, Hong Kong.
Chan JSM; Laboratory of Neuropsychology, The University of Hong Kong, sai wan, Hong Kong.; Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, sai wan, Hong Kong.
Chan CHY; The Department of Social Work and Social Administration, The University of Hong Kong, sai wan, Hong Kong.
So KF; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration Ministry of Education, Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, Guangdong, China.; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, sai wan, Hong Kong.; State Key Laboratory of Brain and Cognitive Science, The University of Hong Kong, sai wan, Hong Kong.
Li A; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration Ministry of Education, Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, Guangdong, China.
Po KKT; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, sai wan, Hong Kong.
Yuen LP; International Association for Health and Yangsheng, sai wan, Hong Kong.
Ku KS; District Elderly Community Service, Haven of Hope Haven of Hope Christian Service, sai wan, Hong Kong.
Choi AWM; Department of Social and Behavioral Sciences, City University of Hong Kong, sai wan, Hong Kong.
Chouliara Z; Division of Mental Health and Counselling, Abertay University, Dundee, United kingdom.
Cheung ACY; The Department of Social Work and Social Administration, The University of Hong Kong, sai wan, Hong Kong.
Chan CLW; The Department of Social Work and Social Administration, The University of Hong Kong, sai wan, Hong Kong.
Emery C; The Department of Social Work and Social Administration, The University of Hong Kong, sai wan, Hong Kong.
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Źródło :
PloS one [PLoS One] 2020 May 15; Vol. 15 (5), pp. e0232932. Date of Electronic Publication: 2020 May 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adult Survivors of Child Abuse/*psychology
Interleukin-6/*immunology
Trust/*psychology
Adult ; Child ; Child Abuse, Sexual/psychology ; Cross-Sectional Studies ; Depression/metabolism ; Female ; Humans ; Inflammation/immunology ; Interleukin-1beta/analysis ; Interleukin-1beta/blood ; Interleukin-6/analysis ; Interleukin-6/blood ; Interpersonal Relations ; Male ; Marriage/psychology ; Mental Disorders/psychology ; Middle Aged ; Risk Factors ; Sexual Partners/psychology
Czasopismo naukowe
Tytuł :
Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance.
Autorzy :
O'Keefe RA; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, United States of America.
Bhola NE; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, United States of America.
Lee DS; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, United States of America.
Johnson DE; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, United States of America.
Grandis JR; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jan 08; Vol. 15 (1), pp. e0227261. Date of Electronic Publication: 2020 Jan 08 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Drug Resistance, Neoplasm/*immunology
Head and Neck Neoplasms/*drug therapy
Interleukin-6/*metabolism
Receptors, Interleukin-6/*metabolism
Squamous Cell Carcinoma of Head and Neck/*drug therapy
Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carbazoles ; Cell Line, Tumor ; Cetuximab/pharmacology ; Cetuximab/therapeutic use ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; Gene Knockdown Techniques ; Head and Neck Neoplasms/immunology ; Head and Neck Neoplasms/pathology ; Humans ; Interleukin-6/genetics ; Interleukin-6/immunology ; Phosphorylation ; RNA, Small Interfering/metabolism ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/immunology ; Recombinant Proteins/immunology ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Signal Transduction/immunology ; Squamous Cell Carcinoma of Head and Neck/immunology ; Squamous Cell Carcinoma of Head and Neck/pathology
Czasopismo naukowe
Tytuł :
Expression of high mobility group B1 and toll-like receptor-nuclear factor κB signaling pathway in chronic subdural hematomas.
Autorzy :
Osuka K; Department of Neurological Surgery, Aichi Medical University Nagakute, Aichi, Japan.
Watanabe Y; High Technology Research Center, Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan.
Usuda N; Department of Anatomy II, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Iwami K; Department of Neurological Surgery, Aichi Medical University Nagakute, Aichi, Japan.
Miyachi S; Department of Neurological Surgery, Aichi Medical University Nagakute, Aichi, Japan.
Takayasu M; Department of Neurological Surgery, Aichi Medical University Nagakute, Aichi, Japan.
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Źródło :
PloS one [PLoS One] 2020 Jun 01; Vol. 15 (6), pp. e0233643. Date of Electronic Publication: 2020 Jun 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HMGB1 Protein/*metabolism
Hematoma, Subdural, Chronic/*metabolism
Interleukin-6/*metabolism
NF-kappa B/*metabolism
Toll-Like Receptor 4/*metabolism
Aged ; Aged, 80 and over ; Endothelium, Vascular/metabolism ; Female ; HMGB1 Protein/genetics ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interleukin-1 Receptor-Associated Kinases/genetics ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Interleukin-6/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; MAP Kinase Kinase Kinases/genetics ; MAP Kinase Kinase Kinases/metabolism ; Male ; Middle Aged ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/genetics ; Signal Transduction ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
Tytuł :
Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.
Autorzy :
Aromolaran AS; Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.; Department of Cell Biology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America.
Srivastava U; Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.; Department of Cell Biology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America.
Alí A; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Chahine M; Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Department of Medicine, Université Laval, Quebec City, Quebec, Canada.
Lazaro D; Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.
El-Sherif N; Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.
Capecchi PL; Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Laghi-Pasini F; Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Lazzerini PE; Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Boutjdir M; Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.; Department of Cell Biology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America.; Departments of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America.; Department of Medicine, New York University School of Medicine, New York, United States of America.
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Źródło :
PloS one [PLoS One] 2018 Dec 06; Vol. 13 (12), pp. e0208321. Date of Electronic Publication: 2018 Dec 06 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arrhythmias, Cardiac/*metabolism
ERG1 Potassium Channel/*metabolism
Inflammation/*metabolism
Interleukin-6/*metabolism
Animals ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/drug therapy ; ERG1 Potassium Channel/antagonists & inhibitors ; ERG1 Potassium Channel/genetics ; Guinea Pigs ; HEK293 Cells ; Humans ; Inflammation/drug therapy ; Long QT Syndrome/drug therapy ; Long QT Syndrome/metabolism ; Membrane Potentials/drug effects ; Receptors, Interleukin-6/metabolism ; Swine
Czasopismo naukowe
Tytuł :
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells.
Autorzy :
Lücke K; Institute of Immunology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Yan I; Institute of Immunology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Krohn S; III. Medical Clinic and Polyclinic, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Volmari A; I. Medical Clinic and Polyclinic, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Klinge S; Institute of Immunology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Schmid J; Institute of Immunology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Schumacher V; Institute of Immunology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Steinmetz OM; III. Medical Clinic and Polyclinic, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Rose-John S; Institute for Biochemistry, Medical Faculty, Christian Albrechts University, Kiel, Germany.
Mittrücker HW; Institute of Immunology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
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Źródło :
PloS one [PLoS One] 2018 Aug 31; Vol. 13 (8), pp. e0203395. Date of Electronic Publication: 2018 Aug 31 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-6/*metabolism
Listeria monocytogenes/*immunology
Listeriosis/*immunology
Listeriosis/*metabolism
Myeloid Cells/*immunology
Signal Transduction/*immunology
ADP-ribosyl Cyclase 1/metabolism ; Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/microbiology ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/microbiology ; Mice ; Mice, Inbred C57BL ; Monocytes/immunology ; Monocytes/metabolism ; Monocytes/microbiology ; Myeloid Cells/metabolism ; Myeloid Cells/microbiology ; Phagocytosis/immunology ; Receptors, Interleukin-4/metabolism ; Receptors, Interleukin-6/metabolism
Czasopismo naukowe
Tytuł :
Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection.
Autorzy :
Townsend L; Department of Infectious Diseases, St James's Hospital, Dublin, Ireland.; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Dyer AH; Department of Immunology, St James's Hospital, Dublin, Ireland.; Department of Medical Gerontology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Jones K; Department of Immunology, St James's Hospital, Dublin, Ireland.
Dunne J; Department of Immunology, St James's Hospital, Dublin, Ireland.
Mooney A; Department of Immunology, St James's Hospital, Dublin, Ireland.
Gaffney F; Department of Immunology, St James's Hospital, Dublin, Ireland.
O'Connor L; Department of Immunology, St James's Hospital, Dublin, Ireland.
Leavy D; Department of Immunology, St James's Hospital, Dublin, Ireland.
O'Brien K; Department of Physiotherapy, St James's Hospital, Dublin, Ireland.
Dowds J; Department of Physiotherapy, St James's Hospital, Dublin, Ireland.
Sugrue JA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Hopkins D; School of Medicine, Trinity College Dublin, Dublin, Ireland.
Martin-Loeches I; Department of Intensive Care Medicine, St James's Hospital, Dublin, Ireland.
Ni Cheallaigh C; Department of Infectious Diseases, St James's Hospital, Dublin, Ireland.; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Nadarajan P; Department of Respiratory Medicine, St James's Hospital, Dublin, Ireland.
McLaughlin AM; Department of Respiratory Medicine, St James's Hospital, Dublin, Ireland.
Bourke NM; Department of Medical Gerontology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Bergin C; Department of Infectious Diseases, St James's Hospital, Dublin, Ireland.; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
O'Farrelly C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Department of Comparative Immunology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Bannan C; Department of Infectious Diseases, St James's Hospital, Dublin, Ireland.; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Conlon N; Department of Immunology, St James's Hospital, Dublin, Ireland.; Department of Immunology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
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Źródło :
PloS one [PLoS One] 2020 Nov 09; Vol. 15 (11), pp. e0240784. Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Infections/*pathology
Fatigue/*etiology
Pneumonia, Viral/*pathology
Adult ; Aged ; Betacoronavirus/isolation & purification ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; Fatigue/epidemiology ; Female ; Humans ; Interleukin-2 Receptor alpha Subunit/blood ; Interleukin-6/blood ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; Prevalence ; Severity of Illness Index
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
G82S RAGE polymorphism influences amyloid-RAGE interactions relevant in Alzheimer's disease pathology.
Autorzy :
C RC; Department of Biotechnology, PSG College of Technology, Coimbatore, Tamil Nadu, India.
Lukose B; Department of Biotechnology, PSG College of Technology, Coimbatore, Tamil Nadu, India.
Rani P; Department of Biotechnology, PSG College of Technology, Coimbatore, Tamil Nadu, India.
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Źródło :
PloS one [PLoS One] 2020 Oct 29; Vol. 15 (10), pp. e0225487. Date of Electronic Publication: 2020 Oct 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*metabolism
Antigens, Neoplasm/*chemistry
Antigens, Neoplasm/*metabolism
Mitogen-Activated Protein Kinases/*chemistry
Mitogen-Activated Protein Kinases/*metabolism
Antigens, Neoplasm/genetics ; Binding Sites ; Cell Line ; Crystallography, X-Ray ; Genetic Predisposition to Disease ; Glycosylation ; Humans ; Interleukin-6/genetics ; Mitogen-Activated Protein Kinases/genetics ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Binding ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Autorzy :
Moutchia J; Bamenda Regional Hospital, Bamenda, Cameroon.; EHESP-French School of Public Health, Paris, France.
Pokharel P; EHESP-French School of Public Health, Paris, France.; School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom.
Kerri A; EHESP-French School of Public Health, Paris, France.; School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom.
McGaw K; EHESP-French School of Public Health, Paris, France.; University of Cambridge, Cambridge, United Kingdom.
Uchai S; EHESP-French School of Public Health, Paris, France.; School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom.
Nji M; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, United States of America.
Goodman M; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Oct 01; Vol. 15 (10), pp. e0239802. Date of Electronic Publication: 2020 Oct 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Coronavirus Infections/*diagnosis
Coronavirus Infections/*pathology
Pneumonia, Viral/*diagnosis
Pneumonia, Viral/*pathology
Betacoronavirus ; C-Reactive Protein/analysis ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Interleukin-6/blood ; Lymphocyte Count ; Observational Studies as Topic ; Pandemics ; Severity of Illness Index ; Troponin I/blood
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment.
Autorzy :
Nazari F; Simon A. Levin Mathematical, Computational, and Modeling Sciences Center, School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America.
Pearson AT; Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, Michigan, United States of America.
Nör JE; Departments of Cardiology, Restorative Sciences, and Endontics, University of Michigan, Ann Arbor, Michigan, United States of America.
Jackson TL; Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2018 Jan 19; Vol. 14 (1), pp. e1005920. Date of Electronic Publication: 2018 Jan 19 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Interleukin-6/*physiology
Neoplasms/*metabolism
Neoplastic Stem Cells/*metabolism
Algorithms ; Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal, Humanized/pharmacology ; Binding Sites ; Cisplatin/pharmacology ; Computer Simulation ; Endothelial Cells/cytology ; Humans ; Interleukin-6/genetics ; Mice ; Mice, SCID ; Models, Theoretical ; Neoplasm Transplantation ; Neoplasms/drug therapy ; Phenotype ; Receptors, Interleukin-6/metabolism ; Signal Transduction ; Time Factors
Czasopismo naukowe
Tytuł :
Alkaloids of Abuta panurensis Eichler: In silico and in vitro study of acetylcholinesterase inhibition, cytotoxic and immunomodulatory activities.
Autorzy :
da Silva Mesquita R; Department of Chemistry, Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil.
Kyrylchuk A; Institute of Organic Chemistry, National Academy of Sciences (NAS), Kyiv, Ukraine.
Costa de Oliveira R; Post-Graduate Program in Hematology, University of the State of Amazonas (UEA), Manaus, Amazonas, Brazil.
Costa Sá IS; Department of Chemistry, Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil.
Coutinho Borges Camargo G; Laboratory of Virology, National Institute of Amazonian Research (INPA), Manaus, Amazonas, Brazil.
Soares Pontes G; Post-Graduate Program in Hematology, University of the State of Amazonas (UEA), Manaus, Amazonas, Brazil.; Laboratory of Virology, National Institute of Amazonian Research (INPA), Manaus, Amazonas, Brazil.
Moura Araújo da Silva F; Analytical Center -Multidisciplinary Support Center (CAM), Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil.
Saraiva Nunomura RC; Department of Chemistry, Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil.
Grafov A; Department of Chemistry, University of Helsinki, Helsinki, Finland.
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Źródło :
PloS one [PLoS One] 2020 Sep 29; Vol. 15 (9), pp. e0239364. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Computer Simulation*
Acetylcholinesterase/*metabolism
Alkaloids/*pharmacology
Antineoplastic Agents/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Immunologic Factors/*pharmacology
Menispermaceae/*chemistry
Alkaloids/metabolism ; Antineoplastic Agents/metabolism ; Cell Line, Tumor ; Cholinesterase Inhibitors/metabolism ; Humans ; Immunologic Factors/metabolism ; Interleukin-6/chemistry ; Interleukin-6/metabolism ; Interleukin-8/chemistry ; Interleukin-8/metabolism ; Molecular Docking Simulation ; Protein Conformation
Czasopismo naukowe
Tytuł :
Lack of RAC1 in macrophages protects against atherosclerosis.
Autorzy :
Bandaru S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ala C; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ekstrand M; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Akula MK; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Pedrelli M; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Liu X; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergström G; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Physiology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
Håversen L; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Borén J; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergo MO; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Akyürek LM; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
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Źródło :
PloS one [PLoS One] 2020 Sep 17; Vol. 15 (9), pp. e0239284. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*metabolism
Macrophages/*metabolism
Neuropeptides/*genetics
rac1 GTP-Binding Protein/*genetics
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Cells, Cultured ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lipid Metabolism ; Mice ; Mice, Inbred C57BL ; Neuropeptides/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Utility of chemokines CCL2, CXCL8, 10 and 13 and interleukin 6 in the pediatric cohort for the recognition of neuroinflammation and in the context of traditional cerebrospinal fluid neuroinflammatory biomarkers.
Autorzy :
Liba Z; Department of Pediatric Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Nohejlova H; Department of Pediatric Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.; Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Capek V; Bioinformatics Centre, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Krsek P; Department of Pediatric Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Sediva A; Department of Immunology, 2 Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Kayserova J; Department of Immunology, 2 Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
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Źródło :
PloS one [PLoS One] 2019 Jul 29; Vol. 14 (7), pp. e0219987. Date of Electronic Publication: 2019 Jul 29 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers/*cerebrospinal fluid
Central Nervous System Diseases/*diagnosis
Chemokines/*cerebrospinal fluid
Interleukin-6/*cerebrospinal fluid
Adolescent ; Biomarkers/blood ; Blood Cell Count ; Central Nervous System Diseases/cerebrospinal fluid ; Central Nervous System Diseases/immunology ; Chemokine CCL2/blood ; Chemokine CCL2/cerebrospinal fluid ; Chemokine CXCL10/blood ; Chemokine CXCL10/cerebrospinal fluid ; Chemokine CXCL13/blood ; Chemokine CXCL13/cerebrospinal fluid ; Chemokines/blood ; Child ; Child, Preschool ; Female ; Humans ; Interleukin-6/blood ; Interleukin-8/blood ; Interleukin-8/cerebrospinal fluid ; Male ; ROC Curve
Czasopismo naukowe
Tytuł :
Interleukin-1β promotes interleulin-6 expression via ERK1/2 signaling pathway in canine dermal fibroblasts.
Autorzy :
Kitanaka N; Laboratory of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.
Nakano R; Laboratory of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.; Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrative Medical Sciences, Suehiro-cho, Tsurumi, Yokohama, Kanagawa, Japan.
Sugiura K; Laboratory of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.
Kitanaka T; Laboratory of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.
Namba S; Laboratory of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.
Konno T; Laboratory of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.
Nakayama T; Laboratory of Veterinary Radiotherapy, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.
Sugiya H; Laboratory of Veterinary Biochemistry, Nihon University College of Bioresource Sciences, Kameino, Fujisawa, Kanagawa, Japan.
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Źródło :
PloS one [PLoS One] 2019 Jul 25; Vol. 14 (7), pp. e0220262. Date of Electronic Publication: 2019 Jul 25 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dermis/*drug effects
Fibroblasts/*drug effects
Interleukin-1beta/*pharmacology
Interleukin-6/*genetics
Animals ; Cells, Cultured ; Dermis/cytology ; Dermis/metabolism ; Dogs ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression Regulation ; Interleukin-6/metabolism ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Male ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice.
Autorzy :
Nishihara M; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Aoki H; Cardiovascular Research Institute, Kurume University, Kurume, Japan.
Ohno S; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Furusho A; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Hirakata S; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Nishida N; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Ito S; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Hayashi M; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Imaizumi T; International University of Health and Welfare, Fukuoka, Japan.
Fukumoto Y; Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
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Źródło :
PloS one [PLoS One] 2017 Oct 05; Vol. 12 (10), pp. e0185923. Date of Electronic Publication: 2017 Oct 05 (Print Publication: 2017).
Typ publikacji :
Journal Article
MeSH Terms :
Aortic Aneurysm, Abdominal/*physiopathology
Interleukin-6/*physiology
Animals ; Antibodies, Neutralizing/immunology ; Disease Models, Animal ; Mice ; Receptors, Interleukin-6/immunology ; Signal Transduction ; Transcriptome
Czasopismo naukowe
Tytuł :
IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis.
Autorzy :
Politano G; Computer Science and Automation Department, Politecnico di Torino, Italy.
Benso A; Computer Science and Automation Department, Politecnico di Torino, Italy.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Sep 30; Vol. 16 (9), pp. e1008238. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Ontology*
Host-Pathogen Interactions*
Betacoronavirus/*physiology
Coronavirus Infections/*virology
Interleukin-6/*physiology
Pneumonia, Viral/*virology
Betacoronavirus/genetics ; Genes, Viral ; Humans ; Pandemics ; Viral Proteins/genetics ; Viral Proteins/physiology
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.
Autorzy :
Sun HB; Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhang YM; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Huang LG; Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Lai QN; Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.
Mo Q; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Ye XZ; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Wang T; Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhu ZZ; Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Lv XL; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Luo YJ; Department of Clinical Laboratory, The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
Gao SD; Department of Infectious Disease, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Xu JS; Department of respiration, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Zhu HH; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
Li T; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.
Wang ZK; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
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Źródło :
PloS one [PLoS One] 2020 Sep 25; Vol. 15 (9), pp. e0239532. Date of Electronic Publication: 2020 Sep 25 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*pathology
Coronavirus Infections/*blood
Coronavirus Infections/*immunology
Cytokines/*blood
Pneumonia, Viral/*blood
Pneumonia, Viral/*immunology
Adolescent ; Adult ; Aged ; Betacoronavirus ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; Child ; Coronavirus Infections/diagnosis ; Female ; Humans ; Interleukin-6/blood ; Lymphopenia/blood ; Lymphopenia/pathology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Severity of Illness Index ; Tumor Necrosis Factor-alpha/blood
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Lyssavirus P-protein selectively targets STAT3-STAT1 heterodimers to modulate cytokine signalling.
Autorzy :
Harrison AR; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Lieu KG; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia.
Larrous F; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France.
Ito N; Laboratory of Zoonotic Diseases, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Bourhy H; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France.
Moseley GW; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 09; Vol. 16 (9), pp. e1008767. Date of Electronic Publication: 2020 Sep 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Cytokines/*metabolism
Lyssavirus/*immunology
Rhabdoviridae Infections/*immunology
STAT1 Transcription Factor/*metabolism
STAT3 Transcription Factor/*metabolism
Viral Proteins/*metabolism
HEK293 Cells ; HeLa Cells ; Humans ; Interleukin-6/metabolism ; Rhabdoviridae Infections/metabolism ; Rhabdoviridae Infections/virology ; STAT1 Transcription Factor/genetics ; STAT3 Transcription Factor/genetics ; Trans-Activators ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Score performance of SAPS 2 and SAPS 3 in combination with biomarkers IL-6, PCT or CRP.
Autorzy :
Jahn M; Department of Nephrology, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.
Rekowski J; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.
Jánosi RA; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.
Kribben A; Department of Nephrology, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.
Canbay A; Department of Medicine, Ruhr-University Bochum, Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum, Germany.
Katsounas A; Department of Medicine, Ruhr-University Bochum, Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum, Germany.
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Źródło :
PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0238587. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Hospital Mortality*
Simplified Acute Physiology Score*
Acute Disease/*mortality
Critical Care/*statistics & numerical data
Hospitals, University/*statistics & numerical data
Intensive Care Units/*statistics & numerical data
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; C-Reactive Protein/analysis ; Female ; Germany ; Humans ; Interleukin-6/blood ; Male ; Middle Aged ; Procalcitonin/blood ; Prognosis ; Retrospective Studies ; Young Adult
Czasopismo naukowe

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