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Tytuł :
Targeting androgen receptor in macrophages inhibits phosphate-induced vascular smooth muscle cell calcification by decreasing IL-6 expression.
Autorzy :
Pang H; The Kidney Diseases and Blood Purification Center, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Xiao L; Department of Urology, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Lu Z; The Kidney Diseases and Blood Purification Center, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Chen H; The Kidney Diseases and Blood Purification Center, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Shang Z; Department of Urology, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Jiang N; Department of Urology, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Wang X; Department of Urology, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Wei F; The Kidney Diseases and Blood Purification Center, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Jiang A; The Kidney Diseases and Blood Purification Center, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
Chen Y; Department of Urology, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China. Electronic address: .
Niu Y; Department of Urology, Tianjin Institute of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China. Electronic address: .
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Źródło :
Vascular pharmacology [Vascul Pharmacol] 2020 Jul; Vol. 130, pp. 106681. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Paracrine Communication*
Interleukin-6/*metabolism
Macrophages/*metabolism
Muscle, Smooth, Vascular/*drug effects
Myocytes, Smooth Muscle/*drug effects
Phosphates/*toxicity
Receptors, Androgen/*metabolism
Vascular Calcification/*metabolism
Actins/metabolism ; Cell Transdifferentiation/drug effects ; Core Binding Factor Alpha 1 Subunit/metabolism ; Down-Regulation ; Humans ; Interleukin-6/genetics ; Macrophages/pathology ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoblasts/pathology ; Osteogenesis/drug effects ; Receptors, Androgen/genetics ; Signal Transduction ; THP-1 Cells ; Vascular Calcification/genetics ; Vascular Calcification/pathology
Czasopismo naukowe
Tytuł :
Complement 3 mediates periodontal destruction in patients with type 2 diabetes by regulating macrophage polarization in periodontal tissues.
Autorzy :
Li Y; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.; Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Wang X; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Wang S; Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Zhu C; Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Guo J; Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Li K; Core Research Laboratory, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
Li A; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.; Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Oct; Vol. 53 (10), pp. e12886. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Complement C3/*metabolism
Diabetes Mellitus, Type 2/*pathology
Macrophages/*immunology
Periodontitis/*diagnosis
Adult ; Alveolar Process/diagnostic imaging ; Alveolar Process/pathology ; Alveolar Process/physiology ; Animals ; Bone Density ; Complement C3/analysis ; Complement C3/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 2/complications ; Female ; Gingival Crevicular Fluid/metabolism ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Macrophage Activation ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Periodontitis/etiology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Lack of RAC1 in macrophages protects against atherosclerosis.
Autorzy :
Bandaru S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ala C; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ekstrand M; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Akula MK; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Pedrelli M; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Liu X; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergström G; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Physiology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
Håversen L; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Borén J; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergo MO; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Akyürek LM; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
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Źródło :
PloS one [PLoS One] 2020 Sep 17; Vol. 15 (9), pp. e0239284. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*metabolism
Macrophages/*metabolism
Neuropeptides/*genetics
rac1 GTP-Binding Protein/*genetics
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Cells, Cultured ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lipid Metabolism ; Mice ; Mice, Inbred C57BL ; Neuropeptides/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Interleukin 6 Promotes Brucella abortus Clearance by Controlling Bactericidal Activity of Macrophages and CD8 T Cell Differentiation.
Autorzy :
Hop HT; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.; Biozentrum, University of Basel, Basel, Switzerland.
Huy TXN; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Reyes AWB; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Arayan LT; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Vu SH; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Min W; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Lee HJ; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Kang CK; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Kim DH; School of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Tark DS; Korea Zoonosis Research Institute, Chonbuk National University, Iksan, Republic of Korea.
Kim S; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea .
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Źródło :
Infection and immunity [Infect Immun] 2019 Oct 18; Vol. 87 (11). Date of Electronic Publication: 2019 Oct 18 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brucella abortus/*physiology
Cytokines/*metabolism
Interleukin-6/*metabolism
Macrophages/*microbiology
Animals ; Antibodies ; Antigen-Presenting Cells ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Cytokines/genetics ; Interleukin-6/genetics ; Mice ; RAW 264.7 Cells ; RNA Interference ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/metabolism ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Th1 Cells/metabolism
Czasopismo naukowe
Tytuł :
Profibrotic Activation of Human Macrophages in Systemic Sclerosis.
Autorzy :
Bhandari R; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Ball MS; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Martyanov V; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Popovich D; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Schaafsma E; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Han S; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
ElTanbouly M; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Orzechowski NM; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Carns M; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Arroyo E; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Aren K; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Hinchcliff M; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Whitfield ML; Geisel School of Medicine at Dartmouth, Hanover and Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Pioli PA; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2020 Jul; Vol. 72 (7), pp. 1160-1169. Date of Electronic Publication: 2020 May 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Fibroblasts/*metabolism
Macrophages/*immunology
Scleroderma, Systemic/*genetics
Skin/*metabolism
Adult ; Antigens, CD/immunology ; Antigens, Differentiation, Myelomonocytic/immunology ; Cell Differentiation ; Chemokine CCL2/genetics ; Chemokine CCL2/immunology ; Coculture Techniques ; Female ; Fibrosis/genetics ; Fibrosis/immunology ; Fibrosis/metabolism ; HLA-DR Antigens/immunology ; Humans ; Immunophenotyping ; Interleukin-6/genetics ; Interleukin-6/immunology ; Lectins, C-Type/immunology ; Leukocytes, Mononuclear ; Macrophage Activation ; Macrophages/metabolism ; Male ; Mannose-Binding Lectins/immunology ; Middle Aged ; Monocytes/metabolism ; Phosphorylation ; RNA, Messenger/metabolism ; Receptor, Transforming Growth Factor-beta Type I/genetics ; Receptor, Transforming Growth Factor-beta Type I/immunology ; Receptor, Transforming Growth Factor-beta Type II/genetics ; Receptor, Transforming Growth Factor-beta Type II/immunology ; Receptors, Cell Surface/immunology ; STAT3 Transcription Factor/metabolism ; Scleroderma, Systemic/immunology ; Scleroderma, Systemic/metabolism ; Skin/pathology ; Transcriptome ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/immunology
Czasopismo naukowe
Tytuł :
Protein C-ets-2 epigenetically suppresses TLRs-induced interleukin 6 production in macrophages.
Autorzy :
Zhao J; Department of Respiration, Zhejiang Medical & Health Group Hangzhou Hospital, 1 Banshan Road, Hangzhou, 310022, Zhejiang, China. Electronic address: .
Huang K; Department of Laboratory Diagnosis, NO.425 Hospital, 86 Sanyawan Road, Sanya, 572000, Hainan, China. Electronic address: .
Peng HZ; Department of Respiration, Zhejiang Medical & Health Group Hangzhou Hospital, 1 Banshan Road, Hangzhou, 310022, Zhejiang, China. Electronic address: .
Feng JF; Department of Laboratory Diagnosis, NO.425 Hospital, 86 Sanyawan Road, Sanya, 572000, Hainan, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Feb 19; Vol. 522 (4), pp. 960-964. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Interleukin-6/*biosynthesis
Macrophages/*metabolism
Proto-Oncogene Protein c-ets-2/*metabolism
Toll-Like Receptors/*metabolism
Acetylation ; Animals ; Cell Line ; Female ; Histone Deacetylase 1/metabolism ; Histones/metabolism ; Humans ; Interleukin-6/genetics ; Mice, Inbred C57BL ; Promoter Regions, Genetic ; Protein Binding
Czasopismo naukowe
Tytuł :
Attempt to Construct an In Vitro Model of Enhancement of Macrophage Phagocytosis Via Continuous Administration of LPS.
Autorzy :
Yamamoto K; Department of Control of Innate Immunity, Technology Research Association, Kagawa, Japan .
Mizobuchi H; Department of Control of Innate Immunity, Technology Research Association, Kagawa, Japan.
Yamashita M; Department of Control of Innate Immunity, Technology Research Association, Kagawa, Japan.
Inagawa H; Department of Control of Innate Immunity, Technology Research Association, Kagawa, Japan.; Macrophi Inc., Kagawa, Japan.; Research Institute for Healthy Living, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Kohchi C; Macrophi Inc., Kagawa, Japan.
Soma GI; Department of Control of Innate Immunity, Technology Research Association, Kagawa, Japan.; Macrophi Inc., Kagawa, Japan.; Research Institute for Healthy Living, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2020 Aug; Vol. 40 (8), pp. 4711-4717.
Typ publikacji :
Journal Article
MeSH Terms :
Lipopolysaccharides/*pharmacology
Macrophages/*drug effects
Phagocytosis/*drug effects
Animals ; Cell Line ; Cytokines/metabolism ; Interleukin-6/metabolism ; Macrophages/metabolism ; Mice ; RAW 264.7 Cells ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Effects of the dietary fibre inulin and Trichuris suis products on inflammatory responses in lipopolysaccharide-stimulated macrophages.
Autorzy :
Myhill LJ; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: .
Jensen P; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Zakeri A; Department of Clinical Medicine, Aarhus University, Denmark.
Nielsen LF; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Jakobsen SR; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Mejer H; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Thamsborg SM; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Nejsum P; Department of Clinical Medicine, Aarhus University, Denmark.
Williams AR; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
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Źródło :
Molecular immunology [Mol Immunol] 2020 May; Vol. 121, pp. 127-135. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Helminth/*pharmacology
Inflammation/*therapy
Inulin/*pharmacology
Macrophages/*drug effects
Trichuris/*immunology
Animals ; Antigens, Helminth/immunology ; Antigens, Helminth/therapeutic use ; Cells, Cultured ; Coculture Techniques ; Dietary Fiber/pharmacology ; Epithelial Cells ; Fatty Acids, Volatile/pharmacology ; Humans ; Inflammation/immunology ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Intestinal Mucosa/cytology ; Lipopolysaccharides/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; RAW 264.7 Cells ; Tumor Necrosis Factor-alpha/immunology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.
Autorzy :
West KO; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Scott HM; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Torres-Odio S; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
West AP; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Patrick KL; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA. Electronic address: .
Watson RO; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Nov 05; Vol. 29 (6), pp. 1594-1609.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Heterogeneous-Nuclear Ribonucleoprotein Group M/*metabolism
Immunity, Innate/*genetics
Interleukin-6/*metabolism
Macrophages/*immunology
RNA Splicing/*immunology
Alternative Splicing/genetics ; Animals ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Immunoprecipitation Sequencing ; Exons ; Gene Expression ; Gene Expression Regulation/genetics ; Gene Expression Regulation/immunology ; Gene Ontology ; Heterogeneous-Nuclear Ribonucleoprotein Group M/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group M/immunology ; Humans ; Interleukin-6/genetics ; Introns ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Macrophages/microbiology ; Macrophages/virology ; Mice ; Mutation ; Phosphorylation ; RAW 264.7 Cells ; RNA Splicing/genetics ; RNA-Seq ; Salmonella/physiology ; Toll-Like Receptor 4/immunology ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Novel and Stable Dual-Color IL-6 and IL-10 Reporters Derived from RAW 264.7 for Anti-Inflammation Screening of Natural Products.
Autorzy :
Saiki P; Biomedical Research Institute, National institute of Advance Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan. .
Kawano Y; Biomedical Research Institute, National institute of Advance Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan. .
Nakajima Y; Health Research Institute, National institute of Advance Industrial Science and Technology, Takamatsu, Kagawa 761-0395, Japan. .
Van Griensven LJLD; Plant Research International, Wageningen University and Research Centre, 6708 PB Wageningen, The Netherlands. .
Miyazaki K; Biomedical Research Institute, National institute of Advance Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Sep 18; Vol. 20 (18). Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Interleukin-10/*analysis
Interleukin-6/*analysis
Macrophages/*drug effects
Animals ; Biological Products/pharmacology ; Biomarkers, Pharmacological/analysis ; Drug Evaluation, Preclinical/methods ; Inflammation/drug therapy ; Inflammation/immunology ; Interleukin-10/immunology ; Interleukin-6/immunology ; Lipopolysaccharides/immunology ; Luminescent Measurements/methods ; Macrophages/immunology ; Mice ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Isolation, characterization and anti-inflammatory mechanism of probiotics in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Autorzy :
Khanna S; Department of Microbiology, Basic Medical Sciences, Block I, South campus, Panjab University, Chandigarh, 160014, India.
Bishnoi M; Healthy Gut Research Group, Food & Nutrition Biotechnology Division, National Agri-Food Biotechnology Institute (NABI), S.A.S. Nagar, Punjab, 140306, India.
Kondepudi KK; Healthy Gut Research Group, Food & Nutrition Biotechnology Division, National Agri-Food Biotechnology Institute (NABI), S.A.S. Nagar, Punjab, 140306, India. .
Shukla G; Department of Microbiology, Basic Medical Sciences, Block I, South campus, Panjab University, Chandigarh, 160014, India. .
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Źródło :
World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2020 May 09; Vol. 36 (5), pp. 74. Date of Electronic Publication: 2020 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*isolation & purification
Anti-Inflammatory Agents/*pharmacology
Lipopolysaccharides/*adverse effects
Macrophages/*drug effects
Probiotics/*isolation & purification
Probiotics/*pharmacology
Animals ; Cell Survival/drug effects ; Cyclooxygenase 2/drug effects ; Cytokines/metabolism ; Inflammation/drug therapy ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Macrophages/immunology ; Mice ; Mitogen-Activated Protein Kinases/drug effects ; Nitric Oxide/metabolism ; Phosphorylation ; RAW 264.7 Cells/drug effects ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Proliferation of Ly6C+ monocytes/macrophages contributes to their accumulation in mouse skin wounds.
Autorzy :
Pang J; Department of Kinesiology and Nutrition, Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois, USA.
Urao N; Department of Kinesiology and Nutrition, Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois, USA.
Koh TJ; Department of Kinesiology and Nutrition, Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Apr; Vol. 107 (4), pp. 551-560. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Wound Healing*
Macrophages/*cytology
Monocytes/*cytology
Skin/*pathology
Animals ; Bone Marrow Cells/cytology ; Cell Proliferation ; Interleukin-1/pharmacology ; Interleukin-1beta/metabolism ; Interleukin-6/pharmacology ; Male ; Mice, Inbred C57BL ; Models, Biological
Czasopismo naukowe
Tytuł :
Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8 T-cells and galectin-3 in the liver.
Autorzy :
Rein-Fischboeck L; Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Haberl EM; Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Bajraktari G; Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Feder S; Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Pohl R; Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Eggenhofer E; Department of Surgery, Experimental Surgery, Regensburg University Hospital, Regensburg, Germany.
Buechler C; Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2020 Apr; Vol. 113, pp. 104363. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Calcium-Binding Proteins/*deficiency
Galectin 3/*metabolism
Liver/*pathology
Macrophages/*pathology
Membrane Proteins/*deficiency
Muscle Proteins/*deficiency
Non-alcoholic Fatty Liver Disease/*immunology
Non-alcoholic Fatty Liver Disease/*prevention & control
Actins/metabolism ; Animals ; Antioxidants/metabolism ; Body Weight ; Calcium-Binding Proteins/metabolism ; Catalase/metabolism ; Cell Line ; Cell Proliferation ; Cell Survival ; Chemokine CCL2/metabolism ; Chemokines/metabolism ; Connective Tissue Growth Factor/metabolism ; Fatty Acid Synthases/metabolism ; Feeding Behavior ; Heme Oxygenase-1/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Interleukin-6/metabolism ; L-Lactate Dehydrogenase/metabolism ; Macrophages/metabolism ; Male ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Muscle Proteins/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Superoxide Dismutase/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Bcl6 modulates innate immunity by controlling macrophage activity and plays critical role in experimental autoimmune encephalomyelitis.
Autorzy :
Li Q; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Zhou L; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Wang L; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Li S; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Xu G; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Gu H; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Li D; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Liu M; Institute of Biomedical Science, East China Normal University, Shanghai, China.
Fang L; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Wang Z; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Han S; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Zheng B; Institute of Biomedical Science, East China Normal University, Shanghai, China.; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
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Źródło :
European journal of immunology [Eur J Immunol] 2020 Apr; Vol. 50 (4), pp. 525-536. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Encephalomyelitis, Autoimmune, Experimental/*immunology
Macrophages/*immunology
Multiple Sclerosis/*immunology
Neutrophils/*immunology
Proto-Oncogene Proteins c-bcl-6/*metabolism
Sepsis/*immunology
Th17 Cells/*immunology
Animals ; Cells, Cultured ; Disease Models, Animal ; Immunity, Innate ; Immunomodulation ; Interleukin-6/genetics ; Macrophage Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Peptide Fragments/immunology ; Proto-Oncogene Proteins c-bcl-6/genetics
Czasopismo naukowe
Tytuł :
IL-6 produced by prostate epithelial cells stimulated with Trichomonas vaginalis promotes proliferation of prostate cancer cells by inducing M2 polarization of THP-1-derived macrophages.
Autorzy :
Han IH; Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul, Korea.
Song HO; Department of Parasitology, School of Medicine, Catholic University of Daegu, Daegu, Korea.
Ryu JS; Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul, Korea.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Mar 20; Vol. 14 (3), pp. e0008126. Date of Electronic Publication: 2020 Mar 20 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*metabolism
Interleukin-6/*metabolism
Macrophages/*drug effects
Prostatic Neoplasms/*pathology
Prostatitis/*complications
Trichomonas Infections/*complications
Trichomonas vaginalis/*immunology
Animals ; Cell Culture Techniques ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Culture Media, Conditioned ; Disease Progression ; Humans ; Male ; Models, Theoretical ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium.
Autorzy :
Liao CW; Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
Chou CH; Department of Obstetrics and Gynecology and Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Wu XM; Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
Chen ZW; Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
Chen YH; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Chang YY; Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Wu VC; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Rose-John S; Institute of Biochemistry, Kiel University, Olshausenstrasse 40, Kiel, Germany.
Hung CS; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Telehealth Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: .
Lin YH; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: .
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Corporate Authors :
TAIPAI Study Group
Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 Mar 01; Vol. 1866 (3), pp. 165627. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aldosterone/*pharmacology
Interleukin-6/*metabolism
Macrophages/*drug effects
Macrophages/*metabolism
Myocardium/*metabolism
Animals ; Cell Line, Tumor ; Fibrosis/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Signal Transduction/physiology ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.
Autorzy :
Philipp D; Department of Cardiothoracic Surgery, Heart Center of the University of Cologne, Cologne, Germany.
Suhr L; Department of Cardiothoracic Surgery, Heart Center of the University of Cologne, Cologne, Germany.
Wahlers T; Department of Cardiothoracic Surgery, Heart Center of the University of Cologne, Cologne, Germany.
Choi YH; Department of Cardiothoracic Surgery, Heart Center of the University of Cologne, Cologne, Germany.
Paunel-Görgülü A; Department of Cardiothoracic Surgery, Heart Center of the University of Cologne, Cologne, Germany. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2018 Oct 25; Vol. 9 (1), pp. 286. Date of Electronic Publication: 2018 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Communication/*immunology
Interferon-gamma/*pharmacology
Interleukin-1beta/*pharmacology
Interleukin-6/*immunology
Macrophages/*immunology
Mesenchymal Stem Cells/*immunology
Animals ; B7-2 Antigen/genetics ; B7-2 Antigen/immunology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Cell Communication/genetics ; Cell Differentiation ; Coculture Techniques ; Dinoprostone/immunology ; Dinoprostone/metabolism ; Gene Expression Regulation ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukin-4/pharmacology ; Interleukin-6/genetics ; Macrophages/cytology ; Macrophages/drug effects ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide/immunology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/immunology ; Receptors, Interleukin-6/deficiency ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/immunology ; Signal Transduction ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Propolis attenuates lipopolysaccharide-induced inflammatory responses through intracellular ROS and NO levels along with downregulation of IL-1β and IL-6 expressions in murine RAW 264.7 macrophages.
Autorzy :
Asgharpour F; Student Research Committee, Babol University of Medical sciences, Babol, Iran.; Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Moghadamnia AA; Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Motallebnejad M; Oral Health Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Nouri HR; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
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Źródło :
Journal of food biochemistry [J Food Biochem] 2019 Aug; Vol. 43 (8), pp. e12926. Date of Electronic Publication: 2019 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*chemically induced
Interleukin-1beta/*metabolism
Interleukin-6/*metabolism
Lipopolysaccharides/*toxicity
Macrophages/*drug effects
Propolis/*pharmacology
Animals ; Cell Survival ; Gene Expression Regulation/drug effects ; Inflammation/drug therapy ; Interleukin-1beta/genetics ; Interleukin-6/genetics ; Macrophages/metabolism ; Mice ; Nitric Oxide/metabolism ; RAW 264.7 Cells ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle.
Autorzy :
Tominaga T; Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Ma S; Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Saitou K; Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.; Neural Circuit Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa 904-0495, Japan.
Suzuki K; Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan. .
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Źródło :
Nutrients [Nutrients] 2019 Jun 30; Vol. 11 (7). Date of Electronic Publication: 2019 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Physical Endurance*
Dietary Sugars/*administration & dosage
Glucose/*administration & dosage
Interleukin-6/*metabolism
Macrophages/*metabolism
Muscle, Skeletal/*metabolism
Animals ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Dietary Sugars/metabolism ; Down-Regulation ; Glucose/metabolism ; Interleukin-6/genetics ; Male ; Mice, Inbred C57BL ; Time Factors
Czasopismo naukowe
Tytuł :
MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.
Autorzy :
Weng YS; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Tseng HY; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Chen YA; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Shen PC; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Al Haq AT; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Chen LM; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Tung YC; Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.
Hsu HL; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. .
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Źródło :
Molecular cancer [Mol Cancer] 2019 Mar 18; Vol. 18 (1), pp. 42. Date of Electronic Publication: 2019 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition*
Cell Cycle Proteins/*metabolism
Interleukin-6/*metabolism
Macrophages/*pathology
MicroRNAs/*genetics
Neoplastic Stem Cells/*pathology
Oncogene Proteins/*metabolism
Receptors, Interleukin-6/*metabolism
Triple Negative Breast Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Cell Proliferation ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-6/genetics ; Macrophages/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplastic Stem Cells/metabolism ; Oncogene Proteins/genetics ; Prognosis ; Receptors, Interleukin-6/genetics ; Signal Transduction ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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