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Tytuł :
Pan-resistant Candida auris isolates from the outbreak in New York are susceptible to ibrexafungerp (a glucan synthase inhibitor).
Autorzy :
Zhu YC; Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
Barat SA; SCYNEXIS, Inc., Jersey City, NJ, USA.
Borroto-Esoda K; SCYNEXIS, Inc., Jersey City, NJ, USA.
Angulo D; SCYNEXIS, Inc., Jersey City, NJ, USA.
Chaturvedi S; Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
Chaturvedi V; Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY, USA. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Apr; Vol. 55 (4), pp. 105922. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Letter
MeSH Terms :
Antifungal Agents/*therapeutic use
Candida/*drug effects
Candida/*genetics
Candidiasis/*drug therapy
Drug Resistance, Multiple, Fungal/*genetics
Glycosides/*therapeutic use
Triterpenes/*therapeutic use
Candida/isolation & purification ; Candidiasis/epidemiology ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Disease Outbreaks ; Glucosyltransferases/antagonists & inhibitors ; Humans ; Microbial Sensitivity Tests ; New York/epidemiology
Opinia redakcyjna
Tytuł :
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
Autorzy :
Orofino F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy.
Truglio GI; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy.
Fiorucci D; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy.
D'Agostino I; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy.
Borgini M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy.
Poggialini F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy.
Zamperini C; Lead Discovery Siena s.r.l., Via Vittorio Alfieri 31, I-53019 Castelnuovo Berardenga, Italy.
Dreassi E; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy.
Maccari L; Lead Discovery Siena s.r.l., Via Vittorio Alfieri 31, I-53019 Castelnuovo Berardenga, Italy.
Torelli R; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Dipartimento di Scienze di Laboratorio e Infettivologiche, Rome, Italy.
Martini C; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Bernabei M; Istituto di Anatomia Patologica, Fondazione Policlinico Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Meis JF; Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands.
Khandelwal NK; School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Prasad R; Amity Institute of Integrative Sciences and Health, Amity University, Gurgaon 122413, Haryana, India.
Sanguinetti M; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Dipartimento di Scienze di Laboratorio e Infettivologiche, Rome, Italy; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Bugli F; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Dipartimento di Scienze di Laboratorio e Infettivologiche, Rome, Italy; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: .
Botta M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, I-53100 Siena, Italy; Lead Discovery Siena s.r.l., Via Vittorio Alfieri 31, I-53019 Castelnuovo Berardenga, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Philadelphia, PA 19122, USA.
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Mar; Vol. 55 (3), pp. 105865. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*pharmacology
Candida/*drug effects
Guanidine/*analogs & derivatives
Urea/*analogs & derivatives
Animals ; Antifungal Agents/therapeutic use ; Azoles/pharmacology ; Candidiasis/drug therapy ; Drug Resistance, Fungal/drug effects ; Guanidine/pharmacology ; Guanidine/therapeutic use ; Microbial Sensitivity Tests ; Rats ; Urea/pharmacology ; Urea/therapeutic use
Czasopismo naukowe
Tytuł :
Itraconazole vs. posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia undergoing intensive chemotherapy: A retrospective study.
Autorzy :
Copley MS; Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, Ohio, 44195, United States. Electronic address: .
Waldron M; Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, Ohio, 44195, United States. Electronic address: .
Athans V; Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, Ohio, 44195, United States. Electronic address: .
Welch SC; Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, Ohio, 44195, United States. Electronic address: .
Brizendine KD; Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, Ohio, 44195, United States. Electronic address: .
Cober E; Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, Ohio, 44195, United States. Electronic address: .
Siebenaller C; Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, Ohio, 44195, United States. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Mar; Vol. 55 (3), pp. 105886. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*therapeutic use
Invasive Fungal Infections/*prevention & control
Itraconazole/*therapeutic use
Leukemia, Myeloid, Acute/*complications
Triazoles/*therapeutic use
Adult ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Humans ; Invasive Fungal Infections/etiology ; Leukemia, Myeloid, Acute/drug therapy ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Colistin interacts synergistically with echinocandins against Candida auris.
Autorzy :
Bidaud AL; Paris-Descartes University, Faculty of Medicine, APHP, European Georges Pompidou Hospital, Parasitology-Mycology Unit, Microbiology department, Paris, France.
Djenontin E; Paris-Descartes University, Faculty of Medicine, APHP, European Georges Pompidou Hospital, Parasitology-Mycology Unit, Microbiology department, Paris, France.
Botterel F; Dynamyc Research Group, Paris Est Créteil University (UPEC, EnvA), France.
Chowdhary A; Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Dannaoui E; Paris-Descartes University, Faculty of Medicine, APHP, European Georges Pompidou Hospital, Parasitology-Mycology Unit, Microbiology department, Paris, France; Dynamyc Research Group, Paris Est Créteil University (UPEC, EnvA), France. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Mar; Vol. 55 (3), pp. 105901. Date of Electronic Publication: 2020 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antifungal Agents/*pharmacology
Candida/*drug effects
Colistin/*pharmacology
Echinocandins/*pharmacology
Anti-Bacterial Agents/therapeutic use ; Antifungal Agents/therapeutic use ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Caspofungin/pharmacology ; Caspofungin/therapeutic use ; Colistin/therapeutic use ; Drug Synergism ; Echinocandins/therapeutic use ; Humans ; Micafungin/pharmacology ; Micafungin/therapeutic use
Czasopismo naukowe
Tytuł :
Antifungal activity of ribavirin used alone or in combination with fluconazole against Candida albicans is mediated by reduced virulence.
Autorzy :
Zhang M; School of Pharmaceutical Sciences, Shandong First Medical University, Tai'an, Shandong Province, China; Department of Pharmacy, Tai'an Municipal Hospital, Tai'an, Shandong Province, China.
Yan H; Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University, Jinan, Shandong Province, China.
Lu M; Department of Pharmacy, Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin, China.
Wang D; School of Pharmaceutical Sciences, Shandong First Medical University, Tai'an, Shandong Province, China.
Sun S; Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University, Jinan, Shandong Province, China. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Jan; Vol. 55 (1), pp. 105804. Date of Electronic Publication: 2019 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*administration & dosage
Biofilms/*drug effects
Candida albicans/*drug effects
Candidiasis/*drug therapy
Fluconazole/*administration & dosage
Ribavirin/*administration & dosage
Animals ; Antifungal Agents/pharmacology ; Candida albicans/pathogenicity ; Candidiasis/microbiology ; Drug Resistance, Fungal ; Drug Synergism ; Fluconazole/pharmacology ; Humans ; Larva ; Moths ; Ribavirin/pharmacology ; Virulence
Czasopismo naukowe
Tytuł :
Analysis of global antifungal surveillance results reveals predominance of Erg11 Y132F alteration among azole-resistant Candida parapsilosis and Candida tropicalis and country-specific isolate dissemination.
Autorzy :
Castanheira M; JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA. Electronic address: .
Deshpande LM; JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.
Messer SA; JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.
Rhomberg PR; JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.
Pfaller MA; JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Jan; Vol. 55 (1), pp. 105799. Date of Electronic Publication: 2019 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Fungal*
Antifungal Agents/*pharmacology
Candida parapsilosis/*enzymology
Candida tropicalis/*enzymology
Candidiasis/*microbiology
Candidiasis, Invasive/*microbiology
Sterol 14-Demethylase/*genetics
Amino Acid Substitution ; Amphotericin B/pharmacology ; Azoles/pharmacology ; Candida albicans/drug effects ; Candida albicans/enzymology ; Candida albicans/genetics ; Candida parapsilosis/drug effects ; Candida parapsilosis/genetics ; Candida tropicalis/drug effects ; Candida tropicalis/genetics ; Candidiasis/drug therapy ; Candidiasis, Invasive/drug therapy ; Echinocandins/pharmacology ; Fluconazole/pharmacology ; Humans ; Microbial Sensitivity Tests ; Voriconazole/pharmacology
SCR Disease Name :
Systemic candidiasis
Czasopismo naukowe
Tytuł :
Anidulafungin as an alternative treatment for Pneumocystis jirovecii pneumonia in patients who cannot tolerate trimethoprim/sulfamethoxazole.
Autorzy :
Chen PY; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan.
Yu CJ; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan.
Chien JY; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan. Electronic address: .
Hsueh PR; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Jan; Vol. 55 (1), pp. 105820. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Anidulafungin/*therapeutic use
Antifungal Agents/*therapeutic use
Echinocandins/*therapeutic use
Pneumocystis carinii/*drug effects
Pneumonia, Pneumocystis/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Pneumonia, Pneumocystis/microbiology ; Retrospective Studies ; Taiwan ; Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects ; Young Adult
Czasopismo naukowe
Tytuł :
Azole resistance mechanisms in Aspergillus: update and recent advances.
Autorzy :
Pérez-Cantero A; Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili and Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, Spain.
López-Fernández L; Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili and Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, Spain.
Guarro J; Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili and Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, Spain.
Capilla J; Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili and Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, Spain. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Jan; Vol. 55 (1), pp. 105807. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Fungal*
Antifungal Agents/*pharmacology
Aspergillus/*genetics
Aspergillus fumigatus/*genetics
Fungal Proteins/*metabolism
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Aspergillus/drug effects ; Aspergillus fumigatus/drug effects ; Azoles/pharmacology ; Cytochrome P450 Family 51/genetics ; Cytochrome P450 Family 51/metabolism ; Fungal Proteins/genetics ; Humans ; Voriconazole/pharmacology
Czasopismo naukowe
Tytuł :
Candida auris in Singapore: Genomic epidemiology, antifungal drug resistance, and identification using the updated 8.01 VITEK 2 system.
Autorzy :
Tan YE; Department of Microbiology, Singapore General Hospital, Singapore. Electronic address: .
Teo JQ; Department of Pharmacy, Singapore General Hospital, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Rahman NBA; Department of Microbiology, Singapore General Hospital, Singapore.
Ng OT; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; National Centre for Infectious Diseases, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Kalisvar M; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; National Centre for Infectious Diseases, Singapore.
Tan AL; Department of Microbiology, Singapore General Hospital, Singapore.
Koh TH; Department of Microbiology, Singapore General Hospital, Singapore.
Ong RTH; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Dec; Vol. 54 (6), pp. 709-715. Date of Electronic Publication: 2019 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Genome, Fungal*
Molecular Epidemiology*
Antifungal Agents/*pharmacology
Candida/*drug effects
Candidiasis/*epidemiology
Candidiasis/*microbiology
Drug Resistance, Fungal ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Humans ; Phylogeny ; Singapore/epidemiology
Czasopismo naukowe
Tytuł :
Prediction models for voriconazole pharmacokinetics based on pharmacogenetics: AN exploratory study in a Spanish population.
Autorzy :
Dapía I; Medical and Molecular Genetics Institute (INGEMM), La Paz University Hospital, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain.
García I; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.
Martinez JC; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.
Arias P; Medical and Molecular Genetics Institute (INGEMM), La Paz University Hospital, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain.
Guerra P; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.
Díaz L; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.
García A; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.
Ochoa D; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Tenorio J; Medical and Molecular Genetics Institute (INGEMM), La Paz University Hospital, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain.
Ramírez E; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.
Román M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Gordo G; Medical and Molecular Genetics Institute (INGEMM), La Paz University Hospital, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain.
Saiz-Rodríguez M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Frías J; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.
Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Lapunzina P; Medical and Molecular Genetics Institute (INGEMM), La Paz University Hospital, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain.
Carcas AJ; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain. Electronic address: .
Borobia AM; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital School of Medicine, Autonomous University of Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Oct; Vol. 54 (4), pp. 463-470. Date of Electronic Publication: 2019 Jul 04.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Genetic Association Studies*
Antifungal Agents/*administration & dosage
Antifungal Agents/*pharmacokinetics
Voriconazole/*administration & dosage
Voriconazole/*pharmacokinetics
Administration, Oral ; Adult ; Female ; Humans ; Male ; Pharmacogenetics/methods ; Randomized Controlled Trials as Topic ; Spain ; Young Adult
Czasopismo naukowe
Tytuł :
Susceptibility profiles and clinical efficacy of antifungals against candida bloodstream isolates from critically ill patients: Focus on intravenous itraconazole.
Autorzy :
Giamarellos-Bourboulis EJ; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece. Electronic address: .
Stamou A; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece.
Maraki S; Department of Clinical Microbiology, University Hospital of Heraklion, Crete, Greece.
Solomonidi N; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece.
Belesiotou E; Department of Clinical Microbiology, Evangelismos General Hospital, Athens, Greece.
Pistiki A; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece.
Antoniadou E; Intensive Care Unit, G.Gennimatas General Hospital, Thessaloniki, Greece.
Vlachogianni G; Intensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece.
Mandragos K; Intensive Care Unit, Korgialeneion Benakeion General Hospital, Athens, Greece.
Tasioudis C; Intensive Care Unit, G.Gennimatas General Hospital, Thessaloniki, Greece.
Katsenos C; Intensive Care Unit, Korgialeneion Benakeion General Hospital, Athens, Greece.
Routsi C; 1(st) Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School, Greece.
Samonis G; Department of Clinical Microbiology, University Hospital of Heraklion, Crete, Greece.
Dimopoulos G; 2(nd) Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School, Greece.
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Oct; Vol. 54 (4), pp. 471-477. Date of Electronic Publication: 2019 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*pharmacology
Antifungal Agents/*therapeutic use
Candida/*drug effects
Candidemia/*drug therapy
Candidemia/*microbiology
Itraconazole/*pharmacology
Itraconazole/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Candida/classification ; Candida/isolation & purification ; Critical Illness ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Prospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens.
Autorzy :
Warrilow AGS; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK.
Parker JE; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK.
Price CL; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK.
Rolley NJ; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK.
Nes WD; Center for Chemical Biology, Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Kelly DE; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK.
Kelly SL; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Oct; Vol. 54 (4), pp. 449-455. Date of Electronic Publication: 2019 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
14-alpha Demethylase Inhibitors/*pharmacology
Antifungal Agents/*pharmacology
Aspergillus fumigatus/*drug effects
Aspergillus fumigatus/*enzymology
Nitriles/*pharmacology
Pyridines/*pharmacology
Triazoles/*pharmacology
Voriconazole/*pharmacology
Aspergillus fumigatus/chemistry ; Cytochrome P450 Family 51/metabolism ; Humans ; Inhibitory Concentration 50 ; Protein Binding ; Recombinant Proteins/metabolism ; Sterols/analysis
Czasopismo naukowe
Tytuł :
Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans.
Autorzy :
Rajasekharan SK; School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Lee JH; School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Lee J; School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Oct; Vol. 54 (4), pp. 518-523. Date of Electronic Publication: 2019 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Antifungal Agents/*pharmacology
Aripiprazole/*pharmacology
Biofilms/*drug effects
Biofilms/*growth & development
Candida albicans/*drug effects
Sterols/*antagonists & inhibitors
Candida albicans/growth & development ; Cell Adhesion/drug effects ; Dose-Response Relationship, Drug ; Hyphae/drug effects ; Hyphae/growth & development ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Pioglitazone as an adjuvant of amphotericin B for the treatment of cryptococcosis.
Autorzy :
Ribeiro NQ; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Santos APN; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Emídio ECP; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Costa MC; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Freitas GJC; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Carmo PHF; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Silva MF; Departamento de Patologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
de Brito CB; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
de Souza DG; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Paixão TA; Departamento de Patologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Santos DA; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Sep; Vol. 54 (3), pp. 301-308. Date of Electronic Publication: 2019 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Amphotericin B/*administration & dosage
Antifungal Agents/*administration & dosage
Antioxidants/*administration & dosage
Cryptococcosis/*drug therapy
Pioglitazone/*administration & dosage
Amphotericin B/pharmacology ; Animals ; Antifungal Agents/pharmacology ; Antioxidants/pharmacology ; Cryptococcosis/pathology ; Cryptococcus gattii/drug effects ; Disease Models, Animal ; Drug Repositioning ; Drug Therapy, Combination/methods ; Mice, Inbred C57BL ; Pioglitazone/pharmacology ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
In vitro activity of nine antifungal agents against a global collection of Hortaea werneckii isolates, the agent of tinea nigra.
Autorzy :
Badali H; Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: .
Al-Hatmi AMS; Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands; Ministry of Health, Directorate General of Health Services, Ibri, Oman; Centre of Expertise in Mycology, Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
Fakhim H; Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Moghaddasi A; Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Khodavaisy S; Zoonoses Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Vaezi A; Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Ahangarkani F; Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
de Hoog GS; Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands; Centre of Expertise in Mycology, Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
Meis JF; Centre of Expertise in Mycology, Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, the Netherlands; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Jul; Vol. 54 (1), pp. 95-98. Date of Electronic Publication: 2019 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Environmental Microbiology*
Antifungal Agents/*pharmacology
Ascomycota/*drug effects
Tinea/*microbiology
Ascomycota/isolation & purification ; Humans ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Echinocandins vs. amphotericin B against invasive candidiasis in children and neonates: A meta-analysis of randomized controlled trials.
Autorzy :
Chen YH; Department of Pharmacy, Chi Mei Medical Center, Liouying, Taiwan.
Cheng IL; Department of Pharmacy, Chi Mei Medical Center, Liouying, Taiwan.
Lai CC; Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.
Tang HJ; Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Jun; Vol. 53 (6), pp. 789-794. Date of Electronic Publication: 2019 Mar 02.
Typ publikacji :
Comparative Study; Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Amphotericin B/*therapeutic use
Antifungal Agents/*therapeutic use
Candidiasis, Invasive/*drug therapy
Echinocandins/*therapeutic use
Adolescent ; Amphotericin B/adverse effects ; Antifungal Agents/adverse effects ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/pathology ; Echinocandins/adverse effects ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Withholding Treatment/statistics & numerical data
Czasopismo naukowe
Tytuł :
Voriconazole inhibits cross-kingdom interactions between Candida albicans and Actinomyces viscosus through the ergosterol pathway.
Autorzy :
Deng L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China.
Zou L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China.
Wu J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China.
Liu H; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China.
Luo T; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China.
Zhou X; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China.
Li W; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China. Electronic address: .
Ren B; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Jun; Vol. 53 (6), pp. 805-813. Date of Electronic Publication: 2019 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Actinomyces viscosus/*drug effects
Antifungal Agents/*pharmacology
Candida albicans/*drug effects
Ergosterol/*metabolism
Metabolic Networks and Pathways/*drug effects
Microbial Interactions/*drug effects
Voriconazole/*pharmacology
Actinomyces viscosus/physiology ; Animals ; Biofilms/drug effects ; Biofilms/growth & development ; Candida albicans/physiology ; Gentian Violet ; Humans ; In Situ Hybridization, Fluorescence ; Microbial Viability/drug effects ; Microscopy, Electron, Scanning ; Provitamins/metabolism ; Staining and Labeling
Czasopismo naukowe
Tytuł :
Antibacterial and antifungal properties of resveratrol.
Autorzy :
Vestergaard M; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Stigbøjlen 4, DK-1870 Frederiksberg C, Denmark.
Ingmer H; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Stigbøjlen 4, DK-1870 Frederiksberg C, Denmark. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Jun; Vol. 53 (6), pp. 716-723. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Repositioning*
Anti-Bacterial Agents/*pharmacology
Antifungal Agents/*pharmacology
Antioxidants/*pharmacology
Bacteria/*drug effects
Fungi/*drug effects
Resveratrol/*pharmacology
Animals ; Bacterial Infections/drug therapy ; Humans ; Mycoses/drug therapy
Czasopismo naukowe
Tytuł :
Outbreak of Candida auris in Spain: A comparison of antifungal activity by three methods with published data.
Autorzy :
Ruiz-Gaitán AC; Severe Infection Research Group, Medical Research Institute La Fe, Valencia, Spain; Department of Clinical Microbiology, Hospital Universitari i Politecnic La Fe, Valencia, Spain.
Cantón E; Severe Infection Research Group, Medical Research Institute La Fe, Valencia, Spain.
Fernández-Rivero ME; Severe Infection Research Group, Medical Research Institute La Fe, Valencia, Spain.
Ramírez P; Department of Critical Care, Hospital Universitari i Politecnic La Fe, Valencia, Spain.
Pemán J; Severe Infection Research Group, Medical Research Institute La Fe, Valencia, Spain; Department of Clinical Microbiology, Hospital Universitari i Politecnic La Fe, Valencia, Spain. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 May; Vol. 53 (5), pp. 541-546. Date of Electronic Publication: 2019 Feb 12.
Typ publikacji :
Comparative Study; Evaluation Study; Journal Article
MeSH Terms :
Disease Outbreaks*
Antifungal Agents/*pharmacology
Candida/*drug effects
Candida/*isolation & purification
Candidiasis/*epidemiology
Microbial Sensitivity Tests/*methods
Blood/microbiology ; Candidiasis/microbiology ; DNA, Ribosomal Spacer ; Humans ; Spain/epidemiology ; Urine/microbiology
Czasopismo naukowe
Tytuł :
Impairing fluoride export of Aspergillus fumigatus mitigates its voriconazole resistance.
Autorzy :
Binder J; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
Held J; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
Krappmann S; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 May; Vol. 53 (5), pp. 689-693. Date of Electronic Publication: 2019 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Fungal*
Antifungal Agents/*pharmacology
Aspergillus fumigatus/*drug effects
Aspergillus fumigatus/*metabolism
Fluorides/*metabolism
Voriconazole/*pharmacology
Biological Transport ; Gene Deletion ; Humans ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Microbial Sensitivity Tests
Czasopismo naukowe

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