JN: "International journal of molecular sciences [Int J Mol Sci] NLMUID: 101092791" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Noscapine and Apoptosis in Breast and Other Cancers.
Autorzy:: Calaf GM; Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.
Crispin LA; Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.
Quisbert-Valenzuela EO; Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 21; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Noscapine*/pharmacology
Glioblastoma*
Antineoplastic Agents*/pharmacology
Breast Neoplasms*/pathology
Male ; Female ; Humans ; bcl-2-Associated X Protein/metabolism ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation

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Skocz do pozycji: 2.

Tytuł:: Effective Targeting of Melanoma Cells by Combination of Mcl-1 and Bcl-2/Bcl-x L /Bcl-w Inhibitors.
Autorzy:: Peng Z; Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.; Clinical Medicine, University of South China, Hengyang 421001, China.
Gillissen B; Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Richter A; Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Sinnberg T; Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.; Division of Dermatooncology, Department of Dermatology, University of Tübingen, 72076 Tübingen, Germany.
Schlaak MS; Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Eberle J; Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 19; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:: Journal Article
MeSH Terms:: Melanoma*/metabolism
Antineoplastic Agents*/pharmacology
Pyrimidines*
Thiophenes*
Humans ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2 ; bcl-X Protein/metabolism ; Apoptosis ; Caspases/metabolism ; Cell Line, Tumor

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Skocz do pozycji: 3.

Tytuł:: Binding Pattern and Structural Interactome of the Anticancer Drug 5-Fluorouracil: A Critical Review.
Autorzy:: Lin ES; Department of Beauty Science, National Taichung University of Science and Technology, Taichung City 403, Taiwan.
Huang CY; Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung City 402, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 17; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 17.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Fluorouracil*/metabolism
Antineoplastic Agents*
Proteins

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Skocz do pozycji: 4.

Tytuł:: Labdane-Type Diterpenoids from Streptomyces griseorubens and Their Antimicrobial and Cytotoxic Activities.
Autorzy:: Heo CS; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of Korea.; Department of Marine Technology and Convergence Engineering, Korea National University of Science and Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Republic of Korea.
Kang JS; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Republic of Korea.
Yang JW; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Republic of Korea.
Lee MA; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of Korea.; Department of Chemistry, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea.
Lee HS; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of Korea.; Department of Chemistry, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea.
Shin HJ; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of Korea.; Department of Marine Technology and Convergence Engineering, Korea National University of Science and Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 14; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Infective Agents*/pharmacology
Anti-Infective Agents*/therapeutic use
Antineoplastic Agents*/therapeutic use
Diterpenes*/chemistry
Neoplasms*/drug therapy
Hematologic Neoplasms*
Streptomyces*
Humans
SCR Organism:: Streptomyces griseorubens

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Skocz do pozycji: 5.

Tytuł:: Navigating the Nexus: HIV and Breast Cancer-A Critical Review.
Autorzy:: Marino A; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, 95123 Catania, Italy.
Pavone G; Medical Oncology Unit, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy.; Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Martorana F; Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Fisicaro V; Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
Motta L; Medical Oncology Unit, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy.; Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Spampinato S; Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
Celesia BM; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, 95123 Catania, Italy.
Cacopardo B; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, 95123 Catania, Italy.
Vigneri P; Medical Oncology Unit, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy.; Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Nunnari G; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, 95123 Catania, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 12; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:: Journal Article; Review
MeSH Terms:: HIV Infections*/complications
HIV Infections*/drug therapy
HIV Infections*/epidemiology
Breast Neoplasms*/epidemiology
Breast Neoplasms*/etiology
Breast Neoplasms*/drug therapy
Neoplasms*/drug therapy
Antineoplastic Agents*/therapeutic use
Humans ; Female ; Immunosuppression Therapy

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Skocz do pozycji: 6.

Tytuł:: Zeolitic Imidazole Framework/Silica Nanocomposite for Targeted Cancer Therapeutics: Comparative Study of Chemo-Drug Cisplatin (CPt) and Green Platinum (GPt) Efficacy.
Autorzy:: Alotaibi HG; Renewable Energy Unit, Basic & Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.; Department of Chemistry, Collage of Science, Imam Muhammad Bin Saud Islamic University, Riyadh 31441, Saudi Arabia.; Department of Nanomedicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Al-Abbad E; Renewable Energy Unit, Basic & Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.; Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Almohazey D; Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Ravinayagam V; Deanship of Scientific Research & Department of Nanomedicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Akhtar S; Department of Biophysics Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Dafalla H; College of Engineering Research (CER), King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.
Jermy BR; Department of Nanomedicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 09; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 09.
Typ publikacji:: Journal Article
MeSH Terms:: Zeolites*/chemistry
Antineoplastic Agents*/pharmacology
Nanocomposites*
Neoplasms*/drug therapy
Humans ; Cisplatin/pharmacology ; Platinum ; Spectroscopy, Fourier Transform Infrared ; Silicon Dioxide/chemistry ; Imidazoles/pharmacology ; Imidazoles/chemistry

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Skocz do pozycji: 7.

Tytuł:: Jozimine A 2 , a Dimeric Naphthylisoquinoline (NIQ) Alkaloid, Shows In Vitro Cytotoxic Effects against Leukemia Cells through NF-κB Inhibition.
Autorzy:: Damiescu R; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Yücer R; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Klauck SM; Division of Cancer Genome Research, German Cancer Research Center (DKFZ) Heidelberg, National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership between DKFZ and University Hospital, 69120 Heidelberg, Germany.
Bringmann G; Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Dawood M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 07; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:: Journal Article
MeSH Terms:: Alkaloids*/pharmacology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Leukemia*/drug therapy
Humans ; Apoptosis ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Endothelial Cells ; Molecular Docking Simulation ; NF-kappa B/pharmacology

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Skocz do pozycji: 8.

Tytuł:: Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro.
Autorzy:: Prylutska S; Department of Plants Physiology, Biochemistry and Bioenergetics, National University of Life and Environmental Sciences of Ukraine, 03041 Kyiv, Ukraine.
Grebinyk A; Deutsches Elektronen-Synchrotron DESY, Platanenallee 6, 15738 Zeuthen, Germany.; Division Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, 15745 Wildau, Germany.
Ponomarenko S; Department of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Gövem D; Division Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, 15745 Wildau, Germany.
Chumachenko V; Department of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Kutsevol N; Department of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Petrovsky M; Department of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Ritter U; Institute of Chemistry and Biotechnology, Technical University of Ilmenau, 98693 Ilmenau, Germany.
Frohme M; Division Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, 15745 Wildau, Germany.
Piosik J; Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland.
Prylutskyy Y; Department of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 06; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:: Journal Article
MeSH Terms:: Polymers*/chemistry
Antineoplastic Agents*/therapeutic use
Acrylic Resins*
Water ; Doxorubicin/chemistry ; Drug Carriers/chemistry ; Micelles

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Skocz do pozycji: 9.

Tytuł:: Modes of Interactions with DNA/HSA Biomolecules and Comparative Cytotoxic Studies of Newly Synthesized Mononuclear Zinc(II) and Heteronuclear Platinum(II)/Zinc(II) Complexes toward Colorectal Cancer Cells.
Autorzy:: Vučelj S; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.; General Hospital of Novi Pazar, Department of Internal Medicine, Generala Živkovića 1, 36300 Novi Pazar, Serbia.
Hasić R; Department of Natural-Mathematical Sciences, State University of Novi Pazar, Vuka Karadžića 9, 36300 Novi Pazar, Serbia.
Ašanin D; Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.
Šmit B; Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.
Caković A; Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Bogojeski J; Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Serafinović MĆ; Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Marković BS; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.
Stojanović B; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.; Faculty of Medical Sciences, Department of Surgery, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.
Pavlović S; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.
Stanisavljević I; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.
Ćorović I; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.; General Hospital of Novi Pazar, Department of Internal Medicine, Generala Živkovića 1, 36300 Novi Pazar, Serbia.
Stojanović MD; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.; Faculty of Medical Sciences, Department of Pathology, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.
Jovanović I; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.
Soldatović TV; Department of Natural-Mathematical Sciences, State University of Novi Pazar, Vuka Karadžića 9, 36300 Novi Pazar, Serbia.
Stojanović B; Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.; Faculty of Medical Sciences, Department of Pathophysiology, University of Kragujevac, S. Markovića 69, 34000 Kragujevac, Serbia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 06; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Colorectal Neoplasms*
Sulfonium Compounds*
Methionine/*analogs & derivatives
Mice ; Animals ; Humans ; Platinum/chemistry ; Molecular Docking Simulation ; Zinc ; DNA/chemistry ; Pyrazines

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Skocz do pozycji: 10.

Tytuł:: Involvement of Ferroptosis Induction and Oxidative Phosphorylation Inhibition in the Anticancer-Drug-Induced Myocardial Injury: Ameliorative Role of Pterostilbene.
Autorzy:: Fujii K; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Fujiwara-Tani R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nukaga S; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ohmori H; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Luo Y; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nishida R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Sasaki T; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Miyagawa Y; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nakashima C; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Kawahara I; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ogata R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ikemoto A; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Sasaki R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Kuniyasu H; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 05; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:: Journal Article
MeSH Terms:: Ferroptosis*
Antineoplastic Agents*/pharmacology
Humans ; Rats ; Animals ; Oxidative Phosphorylation ; Cell Death ; Iron/metabolism

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Skocz do pozycji: 11.

Tytuł:: Metformin in Esophageal Carcinoma: Exploring Molecular Mechanisms and Therapeutic Insights.
Autorzy:: Papadakos SP; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece.
Argyrou A; Academic Department of Gastroenterology, Laikon General Hospital, Athens University Medical School, 11527 Athens, Greece.
Lekakis V; Academic Department of Gastroenterology, Laikon General Hospital, Athens University Medical School, 11527 Athens, Greece.
Arvanitakis K; First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.; Basic and Translational Research Unit (BTRU), Special Unit for Biomedical Research and Education (BRESU), Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Kalisperati P; Pathophysiology Department, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Stergiou IE; Pathophysiology Department, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Konstantinidis I; Department of Internal Medicine, University of Connecticut, Farmington, CT 06030, USA.
Schizas D; First Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Koufakis T; Second Propaedeutic Department of Internal Medicine, General Hospital 'Hippokration', Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Germanidis G; First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.; Basic and Translational Research Unit (BTRU), Special Unit for Biomedical Research and Education (BRESU), Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Theocharis S; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 04; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Metformin*/pharmacology
Antineoplastic Agents*/pharmacology
Esophageal Neoplasms*/drug therapy
Humans ; AMP-Activated Protein Kinases/metabolism ; Signal Transduction

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Skocz do pozycji: 12.

Tytuł:: Dualistic Effects of PRKAR1A as a Potential Anticancer Target in Cancer Cells and Cancer-Derived Stem Cells.
Autorzy:: Baek JW; Department of Biomedical Laboratory Science, Konyang University, Daejeon 35365, Republic of Korea.
Nam AR; Department of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
Kim K; Department of Convergence Medicine, Asan Medical Center, Seoul 05505, Republic of Korea.
Kim PH; Department of Biomedical Laboratory Science, Konyang University, Daejeon 35365, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 01; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Neoplasms*/metabolism
Humans ; Cell Line, Tumor ; Proteomics ; Biomarkers/metabolism ; Transcription Factors/metabolism ; Neoplastic Stem Cells/metabolism ; Epithelial-Mesenchymal Transition ; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/metabolism

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Skocz do pozycji: 13.

Tytuł:: ER Stress-Activated HSF1 Governs Cancer Cell Resistance to USP7 Inhibitor-Based Chemotherapy through the PERK Pathway.
Autorzy:: Lim CH; Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.; BK21 Program, Department of Applied Life Science, Graduate School, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.
Fang XQ; Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.; BK21 Program, Department of Applied Life Science, Graduate School, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.
Kang H; Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.
Oh T; Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.
Lee S; Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.; BK21 Program, Department of Applied Life Science, Graduate School, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.
Kim YS; Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.
Lim JH; Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.; BK21 Program, Department of Applied Life Science, Graduate School, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.; Center for Metabolic Diseases, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 27; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Neoplasms*
Humans ; Ubiquitin-Specific Peptidase 7/genetics ; eIF-2 Kinase/metabolism ; Endoplasmic Reticulum Stress ; Unfolded Protein Response

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Skocz do pozycji: 14.

Tytuł:: Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in Cryptosporidium parvum and HCT-8 Host Cells.
Autorzy:: Ajiboye J; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012 Bern, Switzerland.; Cellular, Molecular and Biomedical Sciences Graduate Program, University of Vermont, Burlington, VT 05405, USA.
Uldry AC; Proteomics and Mass Spectrometry Core Facility, Department for BioMedical Research (DBMR), University of Bern, Länggass-Strasse 122, 3012 Bern, Switzerland.
Heller M; Proteomics and Mass Spectrometry Core Facility, Department for BioMedical Research (DBMR), University of Bern, Länggass-Strasse 122, 3012 Bern, Switzerland.
Naguleswaran A; Institute of Molecular Pathology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012 Bern, Switzerland.
Fan E; Department of Biochemistry, University of Washington, Seattle, WA 98109, USA.
Van Voorhis WC; Center for Emerging and Re-Emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA.
Hemphill A; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012 Bern, Switzerland.
Müller J; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012 Bern, Switzerland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 26; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:: Journal Article
MeSH Terms:: Cryptosporidium parvum*
Cryptosporidiosis*
Cryptosporidium*
Antiprotozoal Agents*/pharmacology
Antineoplastic Agents*/pharmacology
Animals ; Humans ; Quinine/pharmacology

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Skocz do pozycji: 15.

Tytuł:: Pterostilbene Induces Apoptosis from Endoplasmic Reticulum Stress Synergistically with Anticancer Drugs That Deposit Iron in Mitochondria.
Autorzy:: Nishiguch Y; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Fujiwara-Tani R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nukaga S; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Nishida R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ikemoto A; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Sasaki R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Mori S; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Ogata R; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Kishi S; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.; Pathology Laboratory, Research Institute, Tokushukai Nozaki Hospital, 2-10-50 Tanigawa, Daito 574-0074, Osaka, Japan.
Hojo Y; Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan.
Shinohara H; Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan.
Sho M; Department of Surgery, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Kuniyasu H; Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 23; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:: Journal Article
MeSH Terms:: Stomach Neoplasms*/pathology
Antineoplastic Agents*/pharmacology
Stilbenes*/pharmacology
Humans ; Hydrogen Peroxide/metabolism ; Fluorouracil/pharmacology ; Reactive Oxygen Species/metabolism ; Cisplatin/pharmacology ; Doxorubicin/pharmacology ; Apoptosis ; Mitochondria/metabolism ; Endoplasmic Reticulum Stress ; Cell Line, Tumor ; Adaptor Proteins, Signal Transducing/metabolism

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Skocz do pozycji: 16.

Tytuł:: Mechanism of Action of Antitumor Au(I) N-Heterocyclic Carbene Complexes: A Computational Insight on the Targeting of TrxR Selenocysteine.
Autorzy:: Tolbatov I; Department of Physics and Astronomy, University of Padova, Via F. Marzolo 8, 35131 Padova, Italy.
Umari P; Department of Physics and Astronomy, University of Padova, Via F. Marzolo 8, 35131 Padova, Italy.
Marrone A; Dipartimento di Farmacia, Università 'G d'Annunzio' di Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 23; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Coordination Complexes*/chemistry
Methane/*analogs & derivatives
Humans ; Selenocysteine ; Thioredoxin-Disulfide Reductase/metabolism ; Gold/chemistry

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Skocz do pozycji: 17.

Tytuł:: The Conjugates of Indolo[2,3- b ]quinoline as Anti-Pancreatic Cancer Agents: Design, Synthesis, Molecular Docking and Biological Evaluations.
Autorzy:: Cybulski M; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Sidoryk K; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Zaremba-Czogalla M; Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland.
Trzaskowski B; Chemical and Biological Systems Simulation Lab, Center of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.
Kubiszewski M; Pharmaceutical Analysis Laboratory, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Tobiasz J; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Jaromin A; Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland.
Michalak O; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 22; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:: Journal Article
MeSH Terms:: Pancreatic Neoplasms*
Quinolines*
Antineoplastic Agents*
Humans ; Molecular Docking Simulation ; Pancreatic Hormones ; Coumaric Acids ; Multienzyme Complexes ; DNA ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor

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Skocz do pozycji: 18.

Tytuł:: Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development.
Autorzy:: Ranđelović I; KINETO Lab Ltd., 1037 Budapest, Hungary.
Nyíri K; Laboratory of Genome Metabolism and Repair, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, Hungarian Research Network, 1117 Budapest, Hungary.; Department of Applied Biotechnology and Food Science, BME Budapest University of Technology and Economics, 1111 Budapest, Hungary.
Koppány G; Laboratory of Genome Metabolism and Repair, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, Hungarian Research Network, 1117 Budapest, Hungary.; Department of Applied Biotechnology and Food Science, BME Budapest University of Technology and Economics, 1111 Budapest, Hungary.
Baranyi M; KINETO Lab Ltd., 1037 Budapest, Hungary.; Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Tóvári J; Department of Experimental Pharmacology and the National Tumor Biology Laboratory, National Institute of Oncology, 1122 Budapest, Hungary.
Kigyós A; KINETO Lab Ltd., 1037 Budapest, Hungary.
Tímár J; Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Vértessy BG; Laboratory of Genome Metabolism and Repair, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, Hungarian Research Network, 1117 Budapest, Hungary.; Department of Applied Biotechnology and Food Science, BME Budapest University of Technology and Economics, 1111 Budapest, Hungary.
Grolmusz V; Department of Computer Science, Mathematical Institute, Eötvös Loránd University, 1117 Budapest, Hungary.; Uratim Ltd., 1118 Budapest, Hungary.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 22; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:: Journal Article
MeSH Terms:: Pancreatic Neoplasms*/pathology
Adenocarcinoma*/genetics
Antineoplastic Agents*
Humans ; Proto-Oncogene Proteins p21(ras)/metabolism ; Drug Development

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Skocz do pozycji: 19.

Tytuł:: ELK1/MTOR/S6K1 Pathway Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer.
Autorzy:: Zhao L; Department of Pathology and Genomic Medicine, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Wang Y; Department of Pathology and Genomic Medicine, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Sun X; Department of Pathology and Genomic Medicine, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Zhang X; Department of Medicine, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Simone N; Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
He J; Department of Pathology and Genomic Medicine, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 17; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
ets-Domain Protein Elk-1*
Gefitinib*/pharmacology
Gefitinib*/therapeutic use
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Tyrosine Kinase Inhibitors*/pharmacology
Tyrosine Kinase Inhibitors*/therapeutic use
Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/metabolism ; Mice, Nude ; Ribosomal Protein S6 Kinases ; RNA, Small Interfering/pharmacology ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 20.

Tytuł:: Synthesis and Biological Evaluation of Novel Amino and Amido Substituted Pentacyclic Benzimidazole Derivatives as Antiproliferative Agents.
Autorzy:: Perin N; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Gulin M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Kos M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Persoons L; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium.
Daelemans D; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium.
Fabijanić I; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Stojković MR; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Hranjec M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 14; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/chemistry
Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Benzimidazoles/chemistry ; Cell Proliferation ; Molecular Structure

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