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Tytuł :
Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction.
Autorzy :
Reddy SD; Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas.; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, Texas.
Wu X; Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas.
Kuruba R; Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas.
Sridhar V; Texas A&M Institute for Preclinical Studies, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas.
Reddy DS; Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas.
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Źródło :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Nov; Vol. 1480 (1), pp. 116-135. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Hippocampus*/diagnostic imaging
Hippocampus*/metabolism
Hippocampus*/pathology
Interneurons*/metabolism
Interneurons*/pathology
Magnetic Resonance Imaging*
Memory Disorders*/chemically induced
Memory Disorders*/diagnostic imaging
Memory Disorders*/metabolism
Memory Disorders*/pathology
Neurodegenerative Diseases*/chemically induced
Neurodegenerative Diseases*/diagnostic imaging
Neurodegenerative Diseases*/metabolism
Neurodegenerative Diseases*/pathology
Neuroimaging*
Nerve Agents/*poisoning
Soman/*poisoning
Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Time Factors
Czasopismo naukowe
Tytuł :
A selective Na V 1.1 activator with potential for treatment of Dravet syndrome epilepsy.
Autorzy :
Chow CY; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Chin YKY; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Ma L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Undheim EAB; Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD 4072, Australia.
Herzig V; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
King GF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Nov; Vol. 181, pp. 113991. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epilepsies, Myoclonic/*drug therapy
Interneurons/*drug effects
NAV1.1 Voltage-Gated Sodium Channel/*metabolism
Peptides/*pharmacology
Sodium Channel Agonists/*pharmacology
Action Potentials/drug effects ; Amino Acid Sequence ; Animals ; Disease Models, Animal ; Epilepsies, Myoclonic/metabolism ; HEK293 Cells ; Humans ; Interneurons/metabolism ; Mice ; NAV1.1 Voltage-Gated Sodium Channel/genetics ; Patch-Clamp Techniques ; Peptides/chemistry ; Peptides/genetics ; Sequence Homology, Amino Acid ; Sodium Channel Agonists/chemistry ; Spider Venoms/metabolism
Czasopismo naukowe
Tytuł :
Innovations present in the primate interneuron repertoire.
Autorzy :
Krienen FM; Department of Genetics, Harvard Medical School, Boston, MA, USA. .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
Goldman M; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Zhang Q; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
C H Del Rosario R; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Florio M; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Machold R; NYU Neuroscience Institute, Langone Medical Center, New York University, New York, NY, USA.
Saunders A; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Levandowski K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zaniewski H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Schuman B; NYU Neuroscience Institute, Langone Medical Center, New York University, New York, NY, USA.
Wu C; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lutservitz A; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mullally CD; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Reed N; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bien E; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bortolin L; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Fernandez-Otero M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lin JD; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Wysoker A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nemesh J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kulp D; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Burns M; Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Tkachev V; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Smith R; Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
Walsh CA; Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
Dimidschstein J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Rudy B; NYU Neuroscience Institute, Langone Medical Center, New York University, New York, NY, USA.; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, USA.
S Kean L; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Berretta S; Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Fishell G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Feng G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
McCarroll SA; Department of Genetics, Harvard Medical School, Boston, MA, USA. .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
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Źródło :
Nature [Nature] 2020 Oct; Vol. 586 (7828), pp. 262-269. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Primates*
Interneurons/*cytology
Animals ; Callithrix ; Cerebral Cortex/cytology ; Female ; Ferrets ; Hippocampus/cytology ; Humans ; Interneurons/metabolism ; LIM-Homeodomain Proteins/metabolism ; Lysosome-Associated Membrane Glycoproteins/metabolism ; Macaca ; Male ; Mice ; Neostriatum/cytology ; Nerve Tissue Proteins/metabolism ; RNA/genetics ; Species Specificity ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
[Advances on GABAergic interneurons in autism spectrum disorders].
Autorzy :
Li J; School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Xu J; School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.; Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.
Luo J; School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
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Źródło :
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2020 Aug 25; Vol. 49 (4), pp. 508-513.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Autism Spectrum Disorder*/physiopathology
GABAergic Neurons*/pathology
Interneurons*/pathology
Neurology*/trends
Action Potentials ; Humans ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
Deletion of the Mitochondrial Matrix Protein CyclophilinD Prevents Parvalbumin Interneuron Dysfunctionand Cognitive Deficits in a Mouse Model of NMDA Hypofunction.
Autorzy :
Phensy A; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Lindquist KL; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Lindquist KA; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Bairuty D; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Gauba E; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Guo L; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Tian J; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Du H; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas 75080.
Kroener S; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas 75080 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Aug 05; Vol. 40 (32), pp. 6121-6132. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cognitive Dysfunction/*metabolism
Cyclophilin D/*metabolism
GABAergic Neurons/*metabolism
Interneurons/*metabolism
Animals ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/genetics ; Cyclophilin D/genetics ; Excitatory Amino Acid Antagonists/toxicity ; GABAergic Neurons/physiology ; Gene Deletion ; Interneurons/physiology ; Ketamine/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Parvalbumins/genetics ; Parvalbumins/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
CCKergic Tufted Cells Differentially Drive Two Anatomically Segregated Inhibitory Circuits in the Mouse Olfactory Bulb.
Autorzy :
Sun X; Department of Anatomy and Neurobiology, Department of Radiology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Liu X; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Starr ER; Department of Anatomy, Howard University College of Medicine, Washington, DC 20059.
Liu S; Department of Anatomy, Howard University College of Medicine, Washington, DC 20059 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Aug 05; Vol. 40 (32), pp. 6189-6206. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
GABAergic Neurons/*physiology
Interneurons/*physiology
Olfactory Bulb/*cytology
Olfactory Pathways/*cytology
Animals ; Cholecystokinin/genetics ; Cholecystokinin/metabolism ; Female ; GABAergic Neurons/metabolism ; Interneurons/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neural Inhibition ; Olfactory Bulb/physiology ; Olfactory Pathways/physiology ; Synaptic Potentials
Czasopismo naukowe
Tytuł :
Mining the jewels of the cortex's crowning mystery.
Autorzy :
Ibrahim LA; Department of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA. Electronic address: .
Schuman B; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, NYU Neuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Bandler R; Stanley Center at the Broad, 75 Ames St., Cambridge, MA 02142, USA.
Rudy B; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, NYU Neuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA. Electronic address: .
Fishell G; Department of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA; Stanley Center at the Broad, 75 Ames St., Cambridge, MA 02142, USA. Electronic address: .
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Źródło :
Current opinion in neurobiology [Curr Opin Neurobiol] 2020 Aug; Vol. 63, pp. 154-161. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Interneurons*
Pyramidal Cells*
Axons ; Neurons
Czasopismo naukowe
Tytuł :
Complex Movement Control in a Rat Model of Parkinsonian Falls: Bidirectional Control by Striatal Cholinergic Interneurons.
Autorzy :
Avila C; Department of Psychology, University of Michigan, Ann Arbor, Michigan 48103.
Kucinski A; Department of Psychology, University of Michigan, Ann Arbor, Michigan 48103.
Sarter M; Department of Psychology, University of Michigan, Ann Arbor, Michigan 48103 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Jul 29; Vol. 40 (31), pp. 6049-6067. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Interneurons*/drug effects
Neostriatum/*physiopathology
Parasympathetic Nervous System/*physiopathology
Parkinsonian Disorders/*physiopathology
Accidental Falls ; Animals ; Antipsychotic Agents/pharmacology ; Clozapine/pharmacology ; Cues ; Disease Models, Animal ; Dopamine/metabolism ; Dopamine Agents/pharmacology ; Female ; Gait Disorders, Neurologic/drug therapy ; Gait Disorders, Neurologic/physiopathology ; Male ; Observer Variation ; Parasympathetic Nervous System/drug effects ; Rats
Czasopismo naukowe
Tytuł :
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.
Autorzy :
Xiang Y; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Tanaka Y; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Patterson B; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Hwang SM; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Hysolli E; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Cakir B; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Kim KY; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Wang W; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Kang YJ; Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Clement EM; Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Zhong M; Department of Cell Biology, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Lee SH; Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Cho YS; Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Republic of Korea.
Patra P; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA; Department of Biomedical Engineering, University of Bridgeport, Bridgeport, CT 06604, USA.
Sullivan GJ; Department of Molecular Medicine, Hybrid Technology Hub - Centre of Excellence, Institute of Basic Medical Sciences, Oslo University Hospital and University of Oslo, Oslo 0424, Norway; Department of Pediatric Research, Oslo University Hospital Rikshospitalet, Oslo 0372, Norway.
Weissman SM; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Park IH; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jul 02; Vol. 79 (1), pp. 84-98.e9. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Azepines/*pharmacology
Brain/*pathology
Cell Cycle Proteins/*metabolism
Interneurons/*pathology
Methyl-CpG-Binding Protein 2/*physiology
Rett Syndrome/*pathology
Transcription Factors/*metabolism
Transcriptome/*drug effects
Triazoles/*pharmacology
Animals ; Brain/drug effects ; Brain/metabolism ; Cell Cycle Proteins/genetics ; Female ; Human Embryonic Stem Cells/drug effects ; Human Embryonic Stem Cells/metabolism ; Human Embryonic Stem Cells/pathology ; Humans ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Interneurons/drug effects ; Interneurons/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Phenotype ; Rett Syndrome/drug therapy ; Rett Syndrome/genetics ; Rett Syndrome/metabolism ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Differential Expression Hallmarks of Interneurons in Different Types of Focal Cortical Dysplasia.
Autorzy :
Liang C; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Zhang CQ; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Chen X; Department of Neurosurgery, General Hospital of Western Theater Command, No.270 Rongdu Road, Jinniu District, Chengdu, Sichuan, 610083, People's Republic of China.
Wang LK; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Yue J; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
An N; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Zhang L; Department of Histology and Embryology, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Liu SY; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Yang H; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China. .; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China. .
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2020 May; Vol. 70 (5), pp. 796-805. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistant Epilepsy/*pathology
Interneurons/*metabolism
Malformations of Cortical Development/*pathology
Adolescent ; Adult ; Cerebral Cortex/cytology ; Cerebral Cortex/pathology ; Child ; Child, Preschool ; Drug Resistant Epilepsy/metabolism ; Female ; Humans ; Infant ; Interneurons/classification ; Male ; Malformations of Cortical Development/metabolism ; Parvalbumins/genetics ; Parvalbumins/metabolism ; Somatostatin/genetics ; Somatostatin/metabolism ; Vasoactive Intestinal Peptide/genetics ; Vasoactive Intestinal Peptide/metabolism
Czasopismo naukowe
Tytuł :
A circuit model of auditory cortex.
Autorzy :
Park Y; Department of Otorhinolaryngology: HNS, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Geffen MN; Department of Otorhinolaryngology: HNS, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Department of Neuroscience, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Jul 27; Vol. 16 (7), pp. e1008016. Date of Electronic Publication: 2020 Jul 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Computational Biology*
Models, Neurological*
Optogenetics*
Auditory Cortex/*physiology
Interneurons/*physiology
Algorithms ; Animals ; Computer Simulation ; Humans ; Interneurons/classification ; Synapses/physiology ; Thalamus/physiology ; Time Factors
Czasopismo naukowe
Tytuł :
Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in the Drosophila Antennal Lobe.
Autorzy :
Chodankar A; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.; Trinity College Institute of Neuroscience, School of Genetics and Microbiology, Smurfit Institute of Genetics and School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland.
Sadanandappa MK; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755.
VijayRaghavan K; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.
Ramaswami M; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India .; Trinity College Institute of Neuroscience, School of Genetics and Microbiology, Smurfit Institute of Genetics and School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Jul 15; Vol. 40 (29), pp. 5549-5560. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Brain/*growth & development
Habituation, Psychophysiologic/*physiology
Interneurons/*physiology
Smell/*physiology
Animals ; Brain/cytology ; Drosophila melanogaster ; Female ; Interneurons/cytology ; Male ; Odorants
Czasopismo naukowe
Tytuł :
Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk.
Autorzy :
Anderson KM; Department of Psychology, Yale University, New Haven, CT, 06520, USA.
Collins MA; Department of Psychology, Yale University, New Haven, CT, 06520, USA.
Chin R; Department of Psychology, Yale University, New Haven, CT, 06520, USA.
Ge T; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Rosenberg MD; Department of Psychology, Yale University, New Haven, CT, 06520, USA.; Department of Psychology, University of Chicago, Chicago, IL, 60637, USA.
Holmes AJ; Department of Psychology, Yale University, New Haven, CT, 06520, USA. .; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. .; Department of Psychiatry, Yale University, New Haven, CT, 06520, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 08; Vol. 11 (1), pp. 2889. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain/*metabolism
Gene Expression Profiling/*methods
Interneurons/*metabolism
Parvalbumins/*genetics
Schizophrenia/*genetics
Somatostatin/*genetics
Adult ; Animals ; Brain/cytology ; Brain/diagnostic imaging ; Female ; Genome-Wide Association Study/methods ; Humans ; Interneurons/cytology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Parvalbumins/metabolism ; Polymorphism, Single Nucleotide ; Risk Factors ; Schizophrenia/diagnosis ; Schizophrenia/metabolism ; Single-Cell Analysis/methods ; Somatostatin/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.
Autorzy :
Sos KE; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary.
Mayer MI; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary.
Takács VT; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.
Major A; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.
Bardóczi Z; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.
Beres BM; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.
Szeles T; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.
Saito T; Laboratory for Proteolytic Neuroscience, RIKEN, Center for Brain Science, Saitama, Japan.; Department of Neurocognitive Science, Nagoya City University Graduate School of Medical Science, Aichi, Japan.
Saido TC; Laboratory for Proteolytic Neuroscience, RIKEN, Center for Brain Science, Saitama, Japan.
Mody I; Department of Neurology, University of California, Los Angeles, California, United States of America.
Freund TF; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.
Nyiri G; Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, HAS, Budapest, Hungary.
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Źródło :
PloS one [PLoS One] 2020 May 29; Vol. 15 (5), pp. e0233700. Date of Electronic Publication: 2020 May 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Hippocampus/*metabolism
Interneurons/*metabolism
Nerve Net/*metabolism
Peptide Fragments/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Axons/metabolism ; Axons/pathology ; Hippocampus/pathology ; Humans ; Interneurons/pathology ; Memory, Short-Term ; Mice ; Mice, Transgenic ; Nerve Net/pathology ; Peptide Fragments/genetics ; Pyramidal Cells/metabolism ; Pyramidal Cells/pathology ; Receptors, GABA-A/genetics ; Receptors, GABA-A/metabolism
Czasopismo naukowe
Tytuł :
Neural Polyamory: One Cell Forms Meaningful Connections with Hundreds of Partners.
Autorzy :
Rasmussen R; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Ole Worms Allé 8 Aarhus C, Denmark; Aarhus University, Department of Biomedicine, Ole Worms Allé 8 Aarhus C, Denmark.
Sabbagh U; Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, USA. Electronic address: .
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Źródło :
Cell systems [Cell Syst] 2020 May 20; Vol. 10 (5), pp. 381-383.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Interneurons*
Neurons*
Animals ; Mice ; Thalamus
Czasopismo naukowe
Tytuł :
Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior.
Autorzy :
Smith AL; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Jung EM; Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Jeon BT; Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA.
Kim WY; Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 12; Vol. 10 (1), pp. 7834. Date of Electronic Publication: 2020 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Haploinsufficiency*
Autism Spectrum Disorder/*genetics
Intellectual Disability/*genetics
Interneurons/*metabolism
Parvalbumins/*metabolism
Somatostatin/*metabolism
Transcription Factors/*genetics
Animals ; Anxiety/complications ; Autism Spectrum Disorder/complications ; Autism Spectrum Disorder/pathology ; Autism Spectrum Disorder/physiopathology ; Behavior, Animal ; Depression/complications ; Gene Expression Regulation ; Intellectual Disability/complications ; Intellectual Disability/pathology ; Intellectual Disability/physiopathology ; Interneurons/pathology ; Memory ; Phenotype ; Social Behavior ; Spatial Learning
Czasopismo naukowe
Tytuł :
Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia.
Autorzy :
Maas DA; Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behavior, Centre for Neuroscience, Faculty of Science, Radboud University, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands. .; Paris Brain Institute, ICM, Inserm U1127, Sorbonne Université, CNRS UMR 7225, Hôpital Pitié-Salpêtrière, Paris, France. .; Department of Cognitive Neuroscience, Donders Centre for Medical Neuroscience, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands. .
Eijsink VD; Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behavior, Centre for Neuroscience, Faculty of Science, Radboud University, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands.
Spoelder M; Department of Cognitive Neuroscience, Donders Centre for Medical Neuroscience, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands.
van Hulten JA; Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behavior, Centre for Neuroscience, Faculty of Science, Radboud University, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands.
De Weerd P; Department of Neurocognition, Faculty of Psychology and Neurosciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.; Maastricht Centre of Systems Biology (MaCSBio), Faculty of Science and Engineering, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Homberg JR; Department of Cognitive Neuroscience, Donders Centre for Medical Neuroscience, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands.
Vallès A; Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behavior, Centre for Neuroscience, Faculty of Science, Radboud University, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands.; Department of Neurocognition, Faculty of Psychology and Neurosciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Nait-Oumesmar B; Paris Brain Institute, ICM, Inserm U1127, Sorbonne Université, CNRS UMR 7225, Hôpital Pitié-Salpêtrière, Paris, France. .
Martens GJM; Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behavior, Centre for Neuroscience, Faculty of Science, Radboud University, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2020 May 11; Vol. 11 (1), pp. 2329. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognition/*physiology
Interneurons/*pathology
Myelin Sheath/*pathology
Schizophrenia/*pathology
Schizophrenia/*physiopathology
Animals ; Axons/metabolism ; Axons/ultrastructure ; Cell Lineage ; Disease Models, Animal ; GABAergic Neurons/metabolism ; Gene Expression Regulation ; Interneurons/ultrastructure ; Learning ; Myelin Sheath/ultrastructure ; Oligodendroglia/pathology ; Parvalbumins/metabolism ; Prefrontal Cortex/physiopathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar
Czasopismo naukowe
Tytuł :
An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus.
Autorzy :
Morgan JL; John F. Hardesty, Department of Ophthalmology and Visual Science and Departments of Neuroscience and Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63108, USA; Department of Molecular and Cell Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: .
Lichtman JW; Department of Molecular and Cell Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 May 06; Vol. 106 (3), pp. 468-481.e2. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Neural Inhibition*
Interneurons/*physiology
Synapses/*physiology
Thalamus/*cytology
Visual Cortex/*cytology
Animals ; Interneurons/cytology ; Mice ; Mice, Inbred C57BL ; Models, Neurological ; Neuroanatomical Tract-Tracing Techniques ; Thalamus/physiology ; Visual Cortex/physiology
Czasopismo naukowe
Tytuł :
Low-threshold spiking interneurons perform feedback inhibition in the lateral amygdala.
Autorzy :
Ünal ÇT; Department of Psychology, Comparative Cognition Laboratory, TED University, Ziya Gokalp Caddesi No. 48 06420, Kolej Cankaya, Ankara, Turkey.
Ünal B; Department of Psychology, Comparative Cognition Laboratory, TED University, Ziya Gokalp Caddesi No. 48 06420, Kolej Cankaya, Ankara, Turkey.
Bolton MM; Disorders of Neural Circuit Function, Max Planck Florida Institute for Neuroscience, Jupiter, FL, 33458, USA. .
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Źródło :
Brain structure & function [Brain Struct Funct] 2020 Apr; Vol. 225 (3), pp. 909-923. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Action Potentials*
Basolateral Nuclear Complex/*physiology
Interneurons/*physiology
Animals ; Basolateral Nuclear Complex/cytology ; Basolateral Nuclear Complex/metabolism ; Interneurons/cytology ; Interneurons/metabolism ; Male ; Membrane Glycoproteins ; Parvalbumins/analysis ; Receptors, Interleukin-1 ; Somatostatin/analysis
Czasopismo naukowe
Tytuł :
Testosterone stimulates perineuronal nets development around parvalbumin cells in the adult canary brain in parallel with song crystallization.
Autorzy :
Cornez G; GIGA Neuroscience, University of Liege, Liege 4000, Belgium.
Shevchouk OT; GIGA Neuroscience, University of Liege, Liege 4000, Belgium.
Ghorbanpoor S; GIGA Neuroscience, University of Liege, Liege 4000, Belgium.
Ball GF; Department of Psychology, University of Maryland, College Park, MD 20742, USA.
Cornil CA; GIGA Neuroscience, University of Liege, Liege 4000, Belgium.
Balthazart J; GIGA Neuroscience, University of Liege, Liege 4000, Belgium. Electronic address: .
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Źródło :
Hormones and behavior [Horm Behav] 2020 Mar; Vol. 119, pp. 104643. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Canaries/*physiology
Interneurons/*drug effects
Nerve Net/*drug effects
Testosterone/*pharmacology
Vocalization, Animal/*drug effects
Animals ; Brain/cytology ; Brain/drug effects ; Brain/metabolism ; Extracellular Matrix/metabolism ; Female ; Interneurons/cytology ; Interneurons/metabolism ; Interneurons/physiology ; Male ; Nerve Net/metabolism ; Neuronal Plasticity/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Parvalbumins/metabolism ; Seasons ; Songbirds/physiology ; Stereotyped Behavior/drug effects ; Testosterone/blood ; Vocalization, Animal/physiology
Czasopismo naukowe

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