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Tytuł :
Immune responses, subcellular localization, and antiviral activity of interferon-induced protein 35 (IFP35) in rock bream (Oplegnathus fasciatus).
Autorzy :
Madhuranga WSP; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea.
Tharuka MDN; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea.
Harasgama JC; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea.
Kwon H; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea.
Wan Q; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea. Electronic address: .
Lee J; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea. Electronic address: .
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Źródło :
Developmental and comparative immunology [Dev Comp Immunol] 2021 Oct; Vol. 123, pp. 104142. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*metabolism
DNA Virus Infections/*immunology
Fish Proteins/*metabolism
Fishes/*immunology
Intracellular Signaling Peptides and Proteins/*metabolism
Virus Diseases/*immunology
Animals ; Fish Proteins/genetics ; Immunity ; Interferon Type I/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Space ; Iridovirus/physiology ; Protein Transport ; Sequence Alignment
Czasopismo naukowe
Tytuł :
SHIP164 is a chorein motif lipid transfer protein that controls endosome-Golgi membrane traffic.
Autorzy :
Hanna MG; Department of Neuroscience, Yale University School of Medicine, New Haven, CT.; Department of Cell Biology, Yale University School of Medicine, New Haven, CT.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT.
Suen PH; Department of Cell Biology, Yale University School of Medicine, New Haven, CT.
Wu Y; Department of Neuroscience, Yale University School of Medicine, New Haven, CT.; Department of Cell Biology, Yale University School of Medicine, New Haven, CT.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT.
Reinisch KM; Department of Cell Biology, Yale University School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD.
De Camilli P; Department of Neuroscience, Yale University School of Medicine, New Haven, CT.; Department of Cell Biology, Yale University School of Medicine, New Haven, CT.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT.; Kavli Institue for Neuroscience, Yale University School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD.
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Źródło :
The Journal of cell biology [J Cell Biol] 2022 Jun 06; Vol. 221 (6). Date of Electronic Publication: 2022 May 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endosomes*/metabolism
Golgi Apparatus*/metabolism
Intracellular Membranes*/metabolism
Intracellular Signaling Peptides and Proteins*/metabolism
Carrier Proteins/metabolism ; Lipids
Czasopismo naukowe
Tytuł :
Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin.
Autorzy :
Yoshioka Y; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Tachibana Y; Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Uesaka T; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Hioki H; Department of Neuroanatomy, Juntendo University Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Sato Y; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Fukumoto T; Division of Hepato-Biliary-Pancreatic Surgery, Department of Gastroenterological Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Enomoto H; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Jun 11; Vol. 608, pp. 66-72. Date of Electronic Publication: 2022 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Cholecystokinin*/genetics
Cholecystokinin*/metabolism
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Microbiota*
Neurons, Afferent*/metabolism
Peptide Hormones*/genetics
Peptide Hormones*/metabolism
Vagus Nerve*/metabolism
Animals ; Enteroendocrine Cells/metabolism ; Mice ; Nodose Ganglion/metabolism
Czasopismo naukowe
Tytuł :
USP7 sustains an active epigenetic program via stabilizing MLL2 and WDR5 in diffuse large B-cell lymphoma.
Autorzy :
Wu Y; Laboratory of Basic Medicine, Medical College, Nantong University, Nantong, Jiangsu, China.
Gu H; Department of Respiratory Medicine, Nantong Sixth People's Hospital, Nantong, Jiangsu, China.
Bao Y; Department of Emergency Medicine, The Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, China.
Lin T; Laboratory of Basic Medicine, Medical College, Nantong University, Nantong, Jiangsu, China.; Department of Pathophysiology, Nantong University, Nantong, Jiangsu, China.
Wang Z; Laboratory of Basic Medicine, Medical College, Nantong University, Nantong, Jiangsu, China.; Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, China.
Gu D; The Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, China.
Shen H; Department of Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, China.
Xian H; Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, China.
Fan Y; Laboratory of Basic Medicine, Medical College, Nantong University, Nantong, Jiangsu, China.; Department of Pathogenic Biology, Medical College, Nantong University, Nantong, Jiangsu, PR China.
Mao R; Laboratory of Basic Medicine, Medical College, Nantong University, Nantong, Jiangsu, China.; Department of Pathophysiology, Nantong University, Nantong, Jiangsu, China.
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Źródło :
Cell biochemistry and function [Cell Biochem Funct] 2022 Jun; Vol. 40 (4), pp. 379-390. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenesis, Genetic*
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Lymphoma, Large B-Cell, Diffuse*/genetics
Lymphoma, Large B-Cell, Diffuse*/pathology
DNA-Binding Proteins/*metabolism
Neoplasm Proteins/*metabolism
Ubiquitin-Specific Peptidase 7/*metabolism
Cell Line, Tumor ; Humans ; Lysine/genetics ; Lysine/metabolism
Czasopismo naukowe
Tytuł :
Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Autorzy :
Kawamura S; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Matsushita Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Kurosaki S; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Tange M; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Fujiwara N; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Hayata Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Hayakawa Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Suzuki N; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Hata M; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Tsuboi M; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Kishikawa T; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Kinoshita H; Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
Nakatsuka T; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Sato M; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Kudo Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Hoshida Y; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Umemura A; Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Eguchi A; Department of Gastroenterology and Hepatology, Mie University, Mie, Japan.
Ikenoue T; Division of Clinical Genome Research and.
Hirata Y; Division of Advanced Genome Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Uesugi M; Institute for Chemical Research and Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, Japan.
Tateishi R; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Tateishi K; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Fujishiro M; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Koike K; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Nakagawa H; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.; Department of Gastroenterology and Hepatology, Mie University, Mie, Japan.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2022 Jun 01; Vol. 132 (11).
Typ publikacji :
Journal Article
MeSH Terms :
Intracellular Signaling Peptides and Proteins*/antagonists & inhibitors
Intracellular Signaling Peptides and Proteins*/metabolism
Liver Neoplasms*/metabolism
Membrane Proteins*/antagonists & inhibitors
Membrane Proteins*/metabolism
Non-alcoholic Fatty Liver Disease*/metabolism
1-Acylglycerophosphocholine O-Acyltransferase/metabolism ; Animals ; Carcinogenesis ; Mice ; Phosphatidylcholines/metabolism ; Sterol Regulatory Element Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
Overexpression of regucalcin blocks the migration, invasion, and bone metastatic activity of human prostate cancer cells: Crosstalk between cancer cells and bone cells.
Autorzy :
Yamaguchi M; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Hawaii, USA.
Murata T; Laboratory of Molecular Biology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Ramos JW; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Hawaii, USA.
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Źródło :
The Prostate [Prostate] 2022 Jun; Vol. 82 (10), pp. 1025-1039. Date of Electronic Publication: 2022 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms*/secondary
Calcium-Binding Proteins*/biosynthesis
Calcium-Binding Proteins*/genetics
Calcium-Binding Proteins*/metabolism
Intracellular Signaling Peptides and Proteins*/biosynthesis
Intracellular Signaling Peptides and Proteins*/genetics
Prostatic Neoplasms*/genetics
Prostatic Neoplasms*/metabolism
Prostatic Neoplasms*/pathology
Cell Differentiation ; Culture Media, Conditioned ; Humans ; Male ; PC-3 Cells ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1.
Autorzy :
Liu Z; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.
Ye Y; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Liu Y; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.
Liu Y; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.
Chen H; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Shen M; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.
Wang Z; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.
Huang S; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, P.R. China.
Han L; Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
Chen Z; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.
He X; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, P.R. China.
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Źródło :
Cancer research [Cancer Res] 2022 May 16; Vol. 82 (10), pp. 1937-1952.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/pathology
Cyclin D1*/genetics
Cyclin D1*/metabolism
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Liver Neoplasms*/pathology
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
RNA Helicases*/genetics
RNA Helicases*/metabolism
Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans
Czasopismo naukowe
Tytuł :
Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.
Autorzy :
Liao CL; Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Hu RC; Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Liao MS; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Chen YJ; Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Chen YP; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Hsieh HH; Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Tai CH; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Chou TC; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Chu CY; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Chen YJ; Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Lo LC; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Lin JJ; Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
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Źródło :
Journal of cell science [J Cell Sci] 2022 May 15; Vol. 135 (10). Date of Electronic Publication: 2022 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aminopeptidases*/genetics
Aminopeptidases*/metabolism
Cellular Senescence*/genetics
Cellular Senescence*/physiology
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases*/genetics
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases*/metabolism
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Fibroblasts/metabolism ; Fibroblasts/physiology ; Humans ; Proteostasis/genetics ; Proteostasis/physiology ; Serine Endopeptidases/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
SUN2 Modulates the Propagation of HSV-1.
Autorzy :
Cruz-Palomar K; Centre de Recherche du CHU Sainte-Justine, Montréal, Québec, Canada.
Hawkins J; Centre de Recherche du CHU Sainte-Justine, Montréal, Québec, Canada.
Vandal C; Centre de Recherche du CHU Sainte-Justine, Montréal, Québec, Canada.
Quenneville J; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada.
Gagnon É; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada.; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, Québec, Canada.
Lippé R; Centre de Recherche du CHU Sainte-Justine, Montréal, Québec, Canada.; Department of Pathology and Cell Biology, Université de Montréal, Montréal, Québec, Canada.
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Źródło :
Journal of virology [J Virol] 2022 May 11; Vol. 96 (9), pp. e0045322. Date of Electronic Publication: 2022 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Herpesvirus 1, Human*/physiology
Herpesvirus 1, Suid*/genetics
Herpesvirus 1, Suid*/metabolism
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Animals ; Cell Nucleus/metabolism ; Humans ; Nuclear Envelope/metabolism ; Nucleocapsid/metabolism ; Virion/metabolism
Czasopismo naukowe
Tytuł :
Overexpression of cancerous inhibitor ofPP2A ( CIP2A ) in acute myeloid leukemia.
Autorzy :
Hasanin R; Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Mossallam G; Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Elfishawi S; Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Rabea A; Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
Hamdy N; Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
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Źródło :
Expert review of hematology [Expert Rev Hematol] 2022 May; Vol. 15 (5), pp. 465-471. Date of Electronic Publication: 2022 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Autoantigens*/genetics
Autoantigens*/metabolism
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Leukemia, Myeloid, Acute*/diagnosis
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Protein Phosphatase 2*/genetics
Protein Phosphatase 2*/metabolism
Gene Expression ; Humans ; Prognosis
Czasopismo naukowe
Tytuł :
Inhibition of VRK1 suppresses proliferation and migration of vascular smooth muscle cells and intima hyperplasia after injury via mTORC1/β-catenin axis.
Autorzy :
Sun X; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Zhao W; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Wang Q; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Zhao J; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Yang D; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Yang Y; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
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Źródło :
BMB reports [BMB Rep] 2022 May; Vol. 55 (5), pp. 244-249.
Typ publikacji :
Wiadomości
MeSH Terms :
Intracellular Signaling Peptides and Proteins*/antagonists & inhibitors
Intracellular Signaling Peptides and Proteins*/metabolism
Muscle, Smooth, Vascular*/metabolism
Muscle, Smooth, Vascular*/pathology
Neointima*/metabolism
Neointima*/pathology
Protein Serine-Threonine Kinases*/antagonists & inhibitors
Protein Serine-Threonine Kinases*/metabolism
TOR Serine-Threonine Kinases*/metabolism
Vascular System Injuries*/metabolism
Vascular System Injuries*/pathology
beta Catenin*/metabolism
Becaplermin/pharmacology ; Carotid Intima-Media Thickness ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Humans ; Hyperplasia ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Myocytes, Smooth Muscle/metabolism ; Signal Transduction
Periodyk
Tytuł :
Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.
Autorzy :
Vega M; Hematology-Oncology, Greater Los Angeles VA-UCLA Healthcare Center, UCLA and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Chen Y; Molecular Instrumentation Center, UCLA and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Shi Y; Hematology-Oncology, Greater Los Angeles VA-UCLA Healthcare Center, UCLA and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Gera J; Hematology-Oncology, Greater Los Angeles VA-UCLA Healthcare Center, UCLA and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Lichtenstein A; Hematology-Oncology, Greater Los Angeles VA-UCLA Healthcare Center, UCLA and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2022 Apr; Vol. 298 (4), pp. 101750. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Intracellular Signaling Peptides and Proteins*/genetics
Intracellular Signaling Peptides and Proteins*/metabolism
Multiple Myeloma*/drug therapy
Multiple Myeloma*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Humans ; MTOR Inhibitors/pharmacology ; Mitogen-Activated Protein Kinase 3/metabolism ; Mutation ; Phosphorylation/drug effects ; Serine/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Transcriptional profiling of the chick retina identifies down-regulation of VIP and UTS2B genes during early lens-induced myopia.
Autorzy :
Shan SW; Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong. .; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Wang PF; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Cheung JKW; Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong. .; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong.
Yu F; Increasepharm (HK) Limited, 15W Hong Kong Science Park, Hong Kong.
Zheng H; Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong. .; Tianjin Eye Hospital, Tianjin, China.
Luo S; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Yip SP; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong.; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
To CH; Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong. .; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Lam TC; Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong. .; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong.
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Źródło :
Molecular omics [Mol Omics] 2022 Jun 13; Vol. 18 (5), pp. 449-459. Date of Electronic Publication: 2022 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Intracellular Signaling Peptides and Proteins*/genetics
Myopia*/genetics
Myopia*/metabolism
Peptide Hormones*/genetics
Vasoactive Intestinal Peptide*/genetics
Animals ; Chickens/genetics ; Chickens/metabolism ; Down-Regulation ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Nerve Tissue Proteins/genetics ; RNA, Messenger/genetics ; Retina/metabolism
Czasopismo naukowe
Tytuł :
Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase.
Autorzy :
Linville AC; Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, USA.; School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA.
Rico AB; Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, USA.; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska, USA.
Teague H; Department of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Binsted LE; Department of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Smith GL; Department of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Albarnaz JD; Department of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Wiebe MS; Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, USA.; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska, USA.
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Źródło :
Journal of virology [J Virol] 2022 Jun 08; Vol. 96 (11), pp. e0039822. Date of Electronic Publication: 2022 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Immunity, Innate*
Intracellular Signaling Peptides and Proteins*/metabolism
Poxviridae Infections*/immunology
Protein Serine-Threonine Kinases*/metabolism
Vaccinia virus*/enzymology
Vaccinia virus*/physiology
DNA/metabolism ; Humans ; Phosphorylation ; Signal Transduction ; Vaccinia
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.
Autorzy :
Zeinyeh W; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France.
Esvan YJ; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France.
Josselin B; Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff, France.
Defois M; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France.
Baratte B; Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff, France.
Knapp S; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium (SGC), Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.
Chaikuad A; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium (SGC), Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.
Anizon F; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France.
Giraud F; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France. Electronic address: .
Ruchaud S; Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France. Electronic address: .
Moreau P; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jun 05; Vol. 236, pp. 114369. Date of Electronic Publication: 2022 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Intracellular Signaling Peptides and Proteins*/metabolism
Protein Serine-Threonine Kinases*
Humans ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Selective retinal ganglion cell loss and optic neuropathy in a humanized mouse model of familial dysautonomia.
Autorzy :
Chekuri A; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.; Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Logan EM; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Krauson AJ; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Salani M; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Ackerman S; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Kirchner EG; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Bolduc JM; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Wang X; Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Dietrich P; Department of Physiology, The University of Tennessee, Health Science Center, Memphis, TN, USA.
Dragatsis I; Department of Physiology, The University of Tennessee, Health Science Center, Memphis, TN, USA.
Vandenberghe LH; Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Slaugenhaupt SA; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Morini E; Center for Genomic Medicine, Massachusetts General Hospital Research Institute, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2022 Jun 04; Vol. 31 (11), pp. 1776-1787.
Typ publikacji :
Journal Article
MeSH Terms :
Dysautonomia, Familial*/pathology
Intracellular Signaling Peptides and Proteins*
Neurodegenerative Diseases*/pathology
Optic Nerve Diseases*/pathology
Retinal Ganglion Cells*/pathology
Animals ; Disease Models, Animal ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles.
Autorzy :
Angosto-Bazarra D; Línea de Inflamación Molecular, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120, Murcia, Spain. .
Molina-López C; Línea de Inflamación Molecular, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120, Murcia, Spain.
Pelegrín P; Línea de Inflamación Molecular, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120, Murcia, Spain. .; Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, 30120, Murcia, Spain. .
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Źródło :
Communications biology [Commun Biol] 2022 Jun 01; Vol. 5 (1), pp. 524. Date of Electronic Publication: 2022 Jun 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Inflammasomes*/metabolism
Inflammation*/pathology
Intracellular Signaling Peptides and Proteins*/metabolism
Anti-Inflammatory Agents/pharmacology ; Carrier Proteins ; Humans ; Intestines
Czasopismo naukowe
Tytuł :
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Autorzy :
Schrötter S; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Yuskaitis CJ; Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
MacArthur MR; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mitchell SJ; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Hosios AM; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Osipovich M; Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Torrence ME; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mitchell JR; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Hoxhaj G; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sahin M; Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Manning BD; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2022 May 17; Vol. 39 (7), pp. 110824.
Typ publikacji :
Journal Article
MeSH Terms :
Brain*/growth & development
Brain*/metabolism
Intracellular Signaling Peptides and Proteins*/metabolism
Mechanistic Target of Rapamycin Complex 1*/metabolism
Neurons*/cytology
Neurons*/metabolism
Tuberous Sclerosis*/metabolism
Tuberous Sclerosis*/pathology
Tuberous Sclerosis Complex 1 Protein*/metabolism
Tumor Suppressor Proteins*/genetics
Tumor Suppressor Proteins*/metabolism
Animals ; Mice ; Mice, Knockout ; Tuberous Sclerosis Complex 2 Protein/metabolism
SCR Disease Name :
Tuberous Sclerosis 1
Czasopismo naukowe
Tytuł :
Multifaceted and Intricate Oncogenic Mechanisms of NDRG1 in Head and Neck Cancer Depend on Its C-Terminal 3R-Motif.
Autorzy :
You GR; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Chang JT; Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 33302, Taiwan.; School of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Li HF; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Cheng AJ; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 33302, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
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Źródło :
Cells [Cells] 2022 May 07; Vol. 11 (9). Date of Electronic Publication: 2022 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Head and Neck Neoplasms*/genetics
Intracellular Signaling Peptides and Proteins*/genetics
Carcinogenesis/genetics ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Humans
Czasopismo naukowe
Tytuł :
FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development.
Autorzy :
Ji J; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Shen J; Department of Obstetrics and Gynecology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
Xu Y; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Xie M; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Qian Q; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Qiu T; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Shi W; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Ren D; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Ma J; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Liu W; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Liu B; Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2022 May 07; Vol. 13 (5), pp. 442. Date of Electronic Publication: 2022 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
F-Box Proteins*/metabolism
Intracellular Signaling Peptides and Proteins*/metabolism
Membrane Proteins*/metabolism
Ovarian Neoplasms*/pathology
Animals ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Female ; Humans ; Mice ; Nerve Tissue Proteins/metabolism ; SOXD Transcription Factors ; Telomere-Binding Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe

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