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Tytuł :
Intron exon boundary junctions in human genome have in-built unique structural and energetic signals.
Autorzy :
Mishra A; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology Delhi, India.; Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, India.
Siwach P; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology Delhi, India.; Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India.
Misra P; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology Delhi, India.
Dhiman S; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology Delhi, India.
Pandey AK; Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, India.
Srivastava P; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology Delhi, India.
Jayaram B; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology Delhi, India.; Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, India.; Department of Chemistry, Indian Institute of Technology, Delhi, India.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2674-2683.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Exons*
Genome, Human*
Introns*
Genes, Essential ; Genomics ; Humans ; RNA Splice Sites
Czasopismo naukowe
Tytuł :
Restriction of an intron size en route to endothermy.
Autorzy :
Královičová J; University of Southampton, Faculty of Medicine, HDH, Southampton SO16 6YD, UK.; Slovak Academy of Sciences, Centre for Biosciences, 840 05 Bratislava, Slovak Republic.
Borovská I; Slovak Academy of Sciences, Centre for Biosciences, 840 05 Bratislava, Slovak Republic.
Pengelly R; University of Southampton, Faculty of Medicine, HDH, Southampton SO16 6YD, UK.
Lee E; School of Biological Sciences, University of Adelaide, Adelaide 5005, SA, Australia.
Abaffy P; Czech Academy of Sciences, Institute of Biotechnology, 25250 Vestec, Czech Republic.
Šindelka R; Czech Academy of Sciences, Institute of Biotechnology, 25250 Vestec, Czech Republic.
Grutzner F; School of Biological Sciences, University of Adelaide, Adelaide 5005, SA, Australia.
Vořechovský I; University of Southampton, Faculty of Medicine, HDH, Southampton SO16 6YD, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2460-2487.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Introns*
Body Temperature Regulation/*genetics
Ketoglutarate Dehydrogenase Complex/*genetics
Animals ; Calcium/metabolism ; Evolution, Molecular ; Exons ; HEK293 Cells ; Humans ; Interspersed Repetitive Sequences ; Ketoglutarate Dehydrogenase Complex/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Precursors/chemistry ; RNA Precursors/metabolism ; RNA Splice Sites ; RNA Splicing Factors/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Spliceosomes/metabolism ; Vertebrates/genetics
Czasopismo naukowe
Tytuł :
Identification and characterization of constrained non-exonic bases lacking predictive epigenomic and transcription factor binding annotations.
Autorzy :
Grujic O; Computer Science Department, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Phung TN; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Kwon SB; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Arneson A; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Lee Y; Computer Science Department, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Lohmueller KE; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Ernst J; Computer Science Department, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 02; Vol. 11 (1), pp. 6168. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genome*
Introns*
Invertebrates/*genetics
Transcription Factors/*metabolism
Vertebrates/*genetics
Animals ; Base Sequence ; Epigenesis, Genetic ; Evolution, Molecular ; Exons ; Gene Ontology ; Humans ; Molecular Sequence Annotation ; Protein Binding ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Autorzy :
Hsiao HT; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Crichlow GV; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Murphy JW; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Folta-Stogniew EJ; W.M. Keck Biotechnology Research Laboratory, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Lolis EJ; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Braddock DT; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 30; Vol. 15 (11), pp. e0242725. Date of Electronic Publication: 2020 Nov 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Introns*
Promoter Regions, Genetic*
RNA Splice Sites*
Adenoviridae/*chemistry
RNA Splicing Factors/*chemistry
RNA, Viral/*chemistry
Repressor Proteins/*chemistry
Adenoviridae/metabolism ; Crystallography, X-Ray ; Humans ; RNA Splicing Factors/metabolism ; RNA, Viral/metabolism ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Autorzy :
Stoll L; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.; Department of Medicine, Weill Cornell Medicine, 413 East 69th street, New York, NY, USA.
Rodríguez-Trejo A; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Guay C; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Brozzi F; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Bayazit MB; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Gattesco S; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Menoud V; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Sobel J; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Marques AC; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Venø MT; Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Esguerra JLS; Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Barghouth M; Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Suleiman M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Marselli L; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Kjems J; Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Eliasson L; Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Renström E; Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Bouzakri K; UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Pinget M; UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Marchetti P; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Regazzi R; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland. .; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 05; Vol. 11 (1), pp. 5611. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Introns*
Insulin/*genetics
Insulin Secretion/*genetics
RNA, Circular/*metabolism
Animals ; Calcium Signaling ; Cell Nucleus/metabolism ; DNA-Binding Proteins/metabolism ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Gene Expression Regulation ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Mice ; RNA, Circular/genetics ; Rats
Czasopismo naukowe
Tytuł :
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila.
Autorzy :
Li L; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Shanghai, 200032, China.; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China.
Ding Z; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Shanghai, 200032, China.; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China.
Pang TL; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Shanghai, 200032, China.; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China.
Zhang B; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Shanghai, 200032, China.; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China.
Li CH; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China.
Liang AM; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China.
Wang YR; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Shanghai, 200032, China.
Zhou Y; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China.
Fan YJ; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China. .
Xu YZ; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Hubei, 430072, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 05; Vol. 11 (1), pp. 5608. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Introns*
Drosophila Proteins/*genetics
Muscular Atrophy, Spinal/*genetics
Nerve Tissue Proteins/*genetics
Spliceosomes/*pathology
Animals ; Disease Models, Animal ; Drosophila ; Muscular Atrophy, Spinal/pathology ; Mutation ; Phenotype ; RNA Splice Sites ; RNA Splicing/genetics ; RNA, Small Nuclear/genetics ; RNA, Small Nuclear/metabolism ; RNA-Binding Proteins/genetics ; Spliceosomes/genetics
Czasopismo naukowe
Tytuł :
Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing.
Autorzy :
Liu N; Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Dong X; Department of Biological Sciences and RNA Institute, University at Albany, Albany, NY 12222, USA.
Hu C; Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Zeng J; Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Wang J; Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Wang J; Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Wang HW; Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Belfort M; Department of Biological Sciences and RNA Institute, University at Albany, Albany, NY 12222, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 11185-11198.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Introns*
RNA Splicing*
RNA/*metabolism
Ribonucleoproteins/*chemistry
Exons ; Lactococcus lactis/metabolism ; Nucleic Acid Conformation ; Protein Binding ; Protein Conformation ; Spliceosomes/metabolism
Czasopismo naukowe
Tytuł :
[Exon and Intron Variability in Salmonidae Growth Hormone Genes].
Autorzy :
Kamenskaya DN; Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, 690041 Russia.; .
Pankova MV; Far Eastern Federal University, School of Natural Sciences, Vladivostok, 690012 Russia.
Brykov VA; Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, 690041 Russia.; Far Eastern Federal University, School of Natural Sciences, Vladivostok, 690012 Russia.
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Źródło :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2020 Nov-Dec; Vol. 54 (6), pp. 975-979.
Typ publikacji :
Journal Article
MeSH Terms :
Exons*
Gene Duplication*
Introns*
Salmonidae*/genetics
Growth Hormone/*genetics
Animals ; Fish Proteins/genetics
Czasopismo naukowe
Tytuł :
The 206 kbp mitochondrial genome of Phanerochaete carnosa reveals dynamics of introns, accumulation of repeat sequences and plasmid-derived genes.
Autorzy :
Wang X; College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan 450002, China.
Song A; College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan 450002, China.
Wang F; College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan 450002, China.
Chen M; College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan 450002, China.
Li X; College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan 450002, China.
Li Q; College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, Sichuan 610106, China. Electronic address: .
Liu N; College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan 450002, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 01; Vol. 162, pp. 209-219. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Genome, Mitochondrial*
Introns*
Repetitive Sequences, Nucleic Acid*
Phanerochaete/*genetics
Codon Usage ; Cyclooxygenase 1/genetics ; Evolution, Molecular ; Gene Order ; Gene Rearrangement ; Genes, Mitochondrial ; Genomics ; High-Throughput Nucleotide Sequencing ; Phylogeny ; Plasmids/genetics ; Polyporales/genetics
SCR Organism :
Phanerochaete carnosa; Phlebia radiata
Czasopismo naukowe
Tytuł :
Two Novel PLS-Class Pentatricopeptide Repeat Proteins Are Involved in the Group II Intron Splicing of Mitochondrial Transcripts in the Moss Physcomitrella patens.
Autorzy :
Ichinose M; Center for Gene Research, Nagoya University, Nagoya, 464-8602 Japan.; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, 464-8601 Japan.; Faculty of Agriculture, Kyushu University, Fukuoka, 819-0395 Japan.
Ishimaru A; Center for Gene Research, Nagoya University, Nagoya, 464-8602 Japan.
Sugita C; Center for Gene Research, Nagoya University, Nagoya, 464-8602 Japan.
Nakajima K; Center for Gene Research, Nagoya University, Nagoya, 464-8602 Japan.
Kawaguchi Y; Center for Gene Research, Nagoya University, Nagoya, 464-8602 Japan.
Sugita M; Center for Gene Research, Nagoya University, Nagoya, 464-8602 Japan.; Graduate School of Information Science, Nagoya University, Nagoya, 464-8601 Japan.
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Źródło :
Plant & cell physiology [Plant Cell Physiol] 2020 Oct 01; Vol. 61 (10), pp. 1687-1698.
Typ publikacji :
Journal Article
MeSH Terms :
Introns*
RNA Splicing*/genetics
Bryopsida/*metabolism
Mitochondria/*metabolism
Plant Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Bryopsida/genetics ; Gene Knockout Techniques ; Mitochondria/genetics ; Plant Proteins/genetics ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.
Autorzy :
Mopidevi B; Department of Pathology, New York Medical College, Valhalla, New York, USA.
Sivankutty I; Department of Pathology, New York Medical College, Valhalla, New York, USA.
Hao S; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.
Ferreri NR; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.
Kumar A; Department of Pathology, New York Medical College, Valhalla, New York, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Aug 07; Vol. 295 (32), pp. 11068-11081. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Introns*
Blood Pressure/*genetics
Cytochrome P-450 CYP11B2/*genetics
Transcription, Genetic/*genetics
Aldosterone/blood ; Animals ; Cytochrome P-450 CYP11B2/metabolism ; Genes, Reporter ; Humans ; Mice ; Mice, Transgenic ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
DEK46 performs C-to-U editing of a specific site in mitochondrial nad7 introns that is critical for intron splicing and seed development in maize.
Autorzy :
Xu C; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Song S; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Yang YZ; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Lu F; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Zhang MD; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Sun F; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Jia R; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Song R; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
Tan BC; Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.
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Źródło :
The Plant journal : for cell and molecular biology [Plant J] 2020 Aug; Vol. 103 (5), pp. 1767-1782. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Introns*
Mitochondria/*metabolism
Seeds/*growth & development
Zea mays/*growth & development
Edible Grain/growth & development ; Edible Grain/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Proteins/physiology ; RNA Splicing ; RNA, Plant/genetics ; RNA, Plant/metabolism ; Seeds/metabolism ; Zea mays/metabolism
Czasopismo naukowe
Tytuł :
Endothelial Nitric Oxide Synthase Gene Polymorphisms (- 922A > G, - 786 T > C, Intron 4 b/a VNTR and 894 G > T) and Essential Hypertension: An Association Study with Haplotypes Analysis.
Autorzy :
Farbood Z; Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Sabeti Aghabozorgi A; Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Nejatizadeh A; Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Farshidi H; Hormozgan Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Shams L; Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Bahreyni A; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Mansouri Babamansouri E; Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Shekari M; Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. .
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Źródło :
Biochemical genetics [Biochem Genet] 2020 Aug; Vol. 58 (4), pp. 518-532. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Haplotypes*
Introns*
Polymorphism, Single Nucleotide*
Essential Hypertension/*enzymology
Essential Hypertension/*genetics
Nitric Oxide Synthase Type III/*genetics
Adult ; Case-Control Studies ; Essential Hypertension/blood ; Essential Hypertension/epidemiology ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Iran/epidemiology ; Male ; Middle Aged ; Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Spliceosomal Introns: Features, Functions, and Evolution.
Autorzy :
Poverennaya IV; Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia. .; Institute of Mathematical Problems in Biology, Keldysh Branch of Institute of Applied Mathematics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.
Roytberg MA; Institute of Mathematical Problems in Biology, Keldysh Branch of Institute of Applied Mathematics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, 141701, Russia.; Higher School of Economics, Moscow, 101000, Russia.
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Źródło :
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2020 Jul; Vol. 85 (7), pp. 725-734.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Introns*
Spliceosomes*
Alternative Splicing ; Animals ; Conserved Sequence ; Eukaryota/genetics ; Evolution, Molecular ; Exons ; Humans ; RNA/metabolism ; RNA Splicing
Czasopismo naukowe
Tytuł :
Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
Autorzy :
Yue L; Division of Life Science, Center for Stem Cell Research, Center of Systems Biology and Human Health, State Key Laboratory in Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Wan R; Division of Life Science, Center for Stem Cell Research, Center of Systems Biology and Human Health, State Key Laboratory in Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Luan S; Division of Life Science, Center for Stem Cell Research, Center of Systems Biology and Human Health, State Key Laboratory in Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zeng W; Division of Life Science, Center for Stem Cell Research, Center of Systems Biology and Human Health, State Key Laboratory in Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Cheung TH; Division of Life Science, Center for Stem Cell Research, Center of Systems Biology and Human Health, State Key Laboratory in Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong 518057, China. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2020 Jun 22; Vol. 53 (6), pp. 661-676.e6. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Introns*
RNA Processing, Post-Transcriptional*
DNA-Binding Proteins/*metabolism
Oncogene Proteins/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Satellite Cells, Skeletal Muscle/*metabolism
Animals ; Cells, Cultured ; DNA-Binding Proteins/genetics ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Oncogene Proteins/genetics ; Poly-ADP-Ribose Binding Proteins/genetics ; Satellite Cells, Skeletal Muscle/cytology ; Transcriptome
Czasopismo naukowe
Tytuł :
Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing.
Autorzy :
Saha K; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
England W; Department of Pharmaceutical Sciences, University of California Irvine, 147 Bison Modular, Building 515, Irvine, CA 92697, USA.
Fernandez MM; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
Biswas T; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
Spitale RC; Department of Pharmaceutical Sciences, University of California Irvine, 147 Bison Modular, Building 515, Irvine, CA 92697, USA.
Ghosh G; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0375, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 19; Vol. 48 (11), pp. 6294-6309.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Base Pairing*
Exons*/genetics
Introns*/genetics
RNA Splicing*/genetics
Adenoviridae/genetics ; Animals ; Base Sequence ; Enhancer Elements, Genetic ; Gene Silencing ; Mice ; Mouse Embryonic Stem Cells ; Mutation ; RNA Precursors/genetics ; RNA Precursors/metabolism ; Spliceosomes/metabolism ; Transcriptome/genetics ; beta-Globins/genetics
Czasopismo naukowe
Tytuł :
Potential G-Quadruplex Forming Sequences and N -Methyladenosine Colocalize at Human Pre-mRNA Intron Splice Sites.
Autorzy :
Jara-Espejo M; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850, United States.; Department of Morphology, Piracicaba Dental School, University of Campinas-UNICAMP, Av. Limeira 901, Piracicaba, CEP 13414-018 Sao Paulo, Brazil.
Fleming AM; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850, United States.
Burrows CJ; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850, United States.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2020 Jun 19; Vol. 15 (6), pp. 1292-1300. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
G-Quadruplexes*
Introns*
RNA Splice Sites*
Adenosine/*analogs & derivatives
RNA Precursors/*chemistry
Adenosine/analysis ; Adenosine/genetics ; Humans ; Pseudouridine/analysis ; Pseudouridine/genetics ; RNA Precursors/genetics ; RNA Splicing ; Transcriptome
Czasopismo naukowe
Tytuł :
O-GlcNAc regulates gene expression by controlling detained intron splicing.
Autorzy :
Tan ZW; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Fei G; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Bellaousov S; Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Martin SES; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Duveau DY; National Institutes of Health Chemical Genomics Center, Rockville, MD 20850, USA.
Thomas CJ; National Institutes of Health Chemical Genomics Center, Rockville, MD 20850, USA.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Boutz PL; Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.; Center for Biomedical Informatics, University of Rochester, Rochester, NY 14642, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.
Walker S; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 04; Vol. 48 (10), pp. 5656-5669.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Introns*
RNA Splicing*
Acetylglucosamine/*metabolism
Glycoside Hydrolases/*genetics
N-Acetylglucosaminyltransferases/*genetics
Cell Line ; Glycoside Hydrolases/metabolism ; HEK293 Cells ; Humans ; N-Acetylglucosaminyltransferases/antagonists & inhibitors ; N-Acetylglucosaminyltransferases/metabolism ; Phosphorylation ; RNA Splicing Factors/metabolism ; RNA, Messenger/metabolism ; RNA-Seq
Czasopismo naukowe
Tytuł :
Arabidopsis Sucrose Transporter AtSuc1 introns act as strong enhancers of expression.
Autorzy :
Lasin P; Department of Plant and Microbial Biology, University of Minnesota, St. Paul, MN, USA.
Weise A; Aldevron, Antibody Development, Waltershofener Strasse 17, 79111 Freiburg, Germany.
Reinders A; College of Continuing and Professional Studies, University of Minnesota, St. Paul, MN, USA.
Ward JM; Department of Plant and Microbial Biology, University of Minnesota, St. Paul, MN, USA.
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Źródło :
Plant & cell physiology [Plant Cell Physiol] 2020 Jun 01; Vol. 61 (6), pp. 1054-1063.
Typ publikacji :
Journal Article
MeSH Terms :
Introns*/physiology
Arabidopsis/*metabolism
Arabidopsis Proteins/*physiology
Gene Expression Regulation, Plant/*genetics
Membrane Transport Proteins/*metabolism
Plant Proteins/*metabolism
Animals ; Arabidopsis/genetics ; Arabidopsis Proteins/metabolism ; Membrane Transport Proteins/physiology ; Organisms, Genetically Modified ; Plant Proteins/physiology ; Plant Roots/metabolism ; Promoter Regions, Genetic/physiology ; Seedlings/metabolism ; Sucrose/metabolism ; Xenopus
Czasopismo naukowe
Tytuł :
Conserved protein Pir2 mediates gene repression through cryptic introns in lncRNAs.
Autorzy :
Thillainadesan G; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Xiao H; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Holla S; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Dhakshnamoorthy J; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Jenkins LMM; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Wheeler D; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Grewal SIS; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 May 15; Vol. 11 (1), pp. 2412. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Gene Expression Regulation, Fungal*
Introns*
Heat-Shock Proteins/*metabolism
Nuclear Proteins/*metabolism
RNA, Long Noncoding/*metabolism
RNA-Binding Proteins/*metabolism
Schizosaccharomyces/*genetics
Schizosaccharomyces pombe Proteins/*metabolism
Alternative Splicing ; Chromatin/metabolism ; Crosses, Genetic ; Gene Silencing ; Genome, Fungal ; Heat-Shock Proteins/genetics ; Nuclear Proteins/genetics ; RNA Interference ; RNA Splice Sites ; RNA, Long Noncoding/genetics ; RNA-Binding Proteins/genetics ; RNA-Seq ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Transcription, Genetic
Czasopismo naukowe

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