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Tytuł :
Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
Autorzy :
Tao H; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Pan Y; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Chu S; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Li L; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Xie J; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Wang P; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Zhang S; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Reddy S; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Sleasman JW; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA.
Zhong XP; Department of Pediatrics-Allergy and Immunology, Duke University Medical Center, Durham, NC, USA. .; Department of Immunology, Duke University Medical Center, Durham, NC, USA. .; Hematologic Malignancies and Cellular Therapies Program, Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 01; Vol. 12 (1), pp. 2029. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cytokines/*immunology
Inducible T-Cell Co-Stimulator Protein/*immunology
Lymphocyte Activation/*immunology
Mechanistic Target of Rapamycin Complex 1/*immunology
Mechanistic Target of Rapamycin Complex 2/*immunology
Mucosal-Associated Invariant T Cells/*immunology
Animals ; Cell Differentiation/immunology ; Cells, Cultured ; Cytokines/metabolism ; Humans ; Inducible T-Cell Co-Stimulator Protein/metabolism ; Interleukin-15/immunology ; Interleukin-15/metabolism ; Interleukin-2/immunology ; Interleukin-2/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Mucosal-Associated Invariant T Cells/cytology ; Mucosal-Associated Invariant T Cells/metabolism ; Signal Transduction/immunology ; TOR Serine-Threonine Kinases/immunology ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
COVID-19 severity and obesity: are MAIT cells a factor?
Autorzy :
McCarthy C; School of Medicine, University College Dublin, Dublin T04 T6F4, Ireland; Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland. Electronic address: .
O'Donnell CP; Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland.
Kelly NEW; Obesity Immunology Group, Education and Research Centre, University College Dublin, Dublin T04 T6F4, Ireland.
O'Shea D; Obesity Immunology Group, Education and Research Centre, University College Dublin, Dublin T04 T6F4, Ireland.
Hogan AE; Obesity Immunology Group, Education and Research Centre, University College Dublin, Dublin T04 T6F4, Ireland; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, Ireland.
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Źródło :
The Lancet. Respiratory medicine [Lancet Respir Med] 2021 May; Vol. 9 (5), pp. 445-447. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
COVID-19*
Mucosal-Associated Invariant T Cells*
Cytokines ; Humans ; Obesity ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients.
Autorzy :
Deschler S; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Kager J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Erber J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Fricke L; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Koyumdzhieva P; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Georgieva A; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Lahmer T; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Wiessner JR; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Voit F; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Schneider J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Horstmann J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Iakoubov R; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Treiber M; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Winter C; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Ruland J; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany.
Knolle PA; Institute of Molecular Immunology and Experimental Oncology, University Hospital Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Protzer U; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, 81675 Munich, Germany.; German Center for Infection Research (DZIF), 38124 Braunschweig, Partner Site Munich, Germany.
Spinner CD; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.; German Center for Infection Research (DZIF), 38124 Braunschweig, Partner Site Munich, Germany.
Schmid RM; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Quante M; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.; Freiburg University Medical Center, Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Böttcher K; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
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Źródło :
Viruses [Viruses] 2021 Feb 03; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocyte Activation*
COVID-19/*immunology
Mucosal-Associated Invariant T Cells/*immunology
Adaptive Immunity ; COVID-19/physiopathology ; Cytokines/metabolism ; Female ; Granzymes/metabolism ; HLA-DR Antigens ; Humans ; Interleukin-17/metabolism ; Killer Cells, Natural/immunology ; Male ; Mucosal-Associated Invariant T Cells/metabolism ; Severity of Illness Index ; T-Lymphocyte Subsets/immunology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Biological functions of MAIT cells in tissues.
Autorzy :
Klenerman P; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford, OX1 3SY, UK; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), John Radcliffe Hospital, Oxford, OX3 9DU, UK; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, OX3 9DU, UK. Electronic address: .
Hinks TSC; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), John Radcliffe Hospital, Oxford, OX3 9DU, UK; Respiratory Medicine Unit, Nuffield Department of Medicine Experimental Medicine, University of Oxford, OX3 9DU, Oxfordshire, UK.
Ussher JE; Department of Microbiology and Immunology, University of Otago, Dunedin, 9054, Otago, New Zealand; Southern Community Laboratories, Dunedin, 9016, Otago, New Zealand.
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Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 154-158. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mucosal-Associated Invariant T Cells/*immunology
Animals ; Bacterial Infections/immunology ; Homeostasis ; Humans ; Mucosal-Associated Invariant T Cells/cytology ; Mucosal-Associated Invariant T Cells/metabolism ; Neoplasms/immunology ; Receptors, Antigen, T-Cell ; Virus Diseases/immunology
Czasopismo naukowe
Tytuł :
T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells.
Autorzy :
Lepore M; Immunocore Ltd Milton Park, Abingdon, United Kingdom. Electronic address: .
Lewinsohn DA; Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Lewinsohn DM; Department of Medicine, Oregon Health & Science University, Portland VA Medical Center, Portland, OR, United States. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 64-68. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Histocompatibility Antigens Class I/*metabolism
Minor Histocompatibility Antigens/*metabolism
Mucosal-Associated Invariant T Cells/*metabolism
Receptors, Antigen, T-Cell/*immunology
T-Cell Antigen Receptor Specificity/*physiology
T-Lymphocyte Subsets/*immunology
Histocompatibility Antigens Class I/immunology ; Humans ; Immunity, Mucosal/immunology ; Minor Histocompatibility Antigens/immunology ; Mucosal-Associated Invariant T Cells/immunology ; Receptors, Antigen, T-Cell/physiology ; Receptors, Antigen, T-Cell, alpha-beta
Czasopismo naukowe
Tytuł :
Translating viral vaccines into immunity.
Autorzy :
Juno JA; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity at the University of Melbourne, Melbourne, VIC, Australia. .
O'Connor SL; Department of Pathology and Laboratory Medicine, The University of Wisconsin-Madison, Madison, WI, USA. .; Wisconsin National Primate Research Center, Madison, WI, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 29; Vol. 371 (6528), pp. 460-461.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Mucosal-Associated Invariant T Cells*
Viral Vaccines*
Adenoviridae ; Immunity, Humoral ; Immunogenicity, Vaccine
Czasopismo naukowe
Tytuł :
Targeting mitochondrial dysfunction in MAIT cells: Potential immunotherapeutic treatment for colorectal cancer.
Autorzy :
Lin D; Shengli Clinical Medical College of Fujian Medical University, Department of Gastrointestinal Surgery of Fujian Provincial Hospital, N0. 134, East Avenue, Fuzhou 350001, Fujian Province, China.
Zhong S; Shengli Clinical Medical College of Fujian Medical University, Department of Digestive Endoscopy of Fujian Provincial Hospital, N0. 134, East Avenue, Fuzhou 350001, Fujian Province, China.
Liu J; Shengli Clinical Medical College of Fujian Medical University, Department of Gastrointestinal Surgery of Fujian Provincial Hospital, N0. 134, East Avenue, Fuzhou 350001, Fujian Province, China. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Jan; Vol. 146, pp. 110358. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Colonic Neoplasms*
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/therapy
Mucosal-Associated Invariant T Cells*/metabolism
Humans ; Immunotherapy ; Mitochondria ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Mucosal associated invariant T cells are differentially impaired in tolerant and immunosuppressed liver transplant recipients.
Autorzy :
Sattler A; Department for General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Thiel LG; Department for General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Ruhm AH; Department for General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Bergmann Y; Department for General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Dornieden T; Department for General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Choi M; Department for Nephrology and Internal Intensive Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Halleck F; Department for Nephrology and Internal Intensive Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Friedersdorff F; Department for Urology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Eurich D; Department for Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Kotsch K; Department for General, Visceral and Vascular Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
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Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2021 Jan; Vol. 21 (1), pp. 87-102. Date of Electronic Publication: 2020 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver Transplantation*
Mucosal-Associated Invariant T Cells*
Cytokines ; Humans ; Lymphocyte Activation ; Phenotype
Czasopismo naukowe
Tytuł :
Boosting MAIT cells as immunotherapy: context is everything.
Autorzy :
Hinks TSC; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford, OX3 9DU, UK. .
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Źródło :
Mucosal immunology [Mucosal Immunol] 2021 Jan; Vol. 14 (1), pp. 1-3. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Mucosal-Associated Invariant T Cells*
Tuberculosis*
Humans ; Immunotherapy
Czasopismo naukowe
Tytuł :
Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.
Autorzy :
Sasson SC; Translational Gastroenterology Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Zaunders JJ; Centre for Applied Medical Research, St Vincent's Hospital, Sydney, Australia.
Nahar K; Melanoma Institute Australia and The University of Sydney, Sydney, Australia.
Munier CML; The Kirby Institute, University of New South Wales, Sydney, Australia.
Fairfax BP; Department of Oncology, Churchill Hospital, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK.; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Olsson-Brown A; The Clatterbridge Cancer Centre NHS Foundation Trust and Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Jolly C; The Clatterbridge Cancer Centre NHS Foundation Trust and Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Read SA; Westmead Institute of Medical Research, Sydney, Australia.; Western Sydney University, Sydney, Australia.
Ahlenstiel G; Westmead Institute of Medical Research, Sydney, Australia.; Department of Gastroenterology, Blacktown Hospital, Sydney, Australia.
Palendira U; Discipline of Infectious Diseases and Immunology, The University of Sydney, Sydney, Australia.
Scolyer RA; Melanoma Institute Australia and The University of Sydney, Sydney, Australia.; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
Carlino MS; Melanoma Institute Australia and The University of Sydney, Sydney, Australia.; Department of Medical Oncology, Westmead and Blacktown Hospitals, Sydney, Australia.
Payne MJ; Department of Oncology, Churchill Hospital, Oxford, UK.
Cheung VTF; Translational Gastroenterology Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Gupta T; Translational Gastroenterology Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Klenerman P; Translational Gastroenterology Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building of Pathogen Research, University of Oxford, Oxford, UK.
Long GV; Melanoma Institute Australia and The University of Sydney, Sydney, Australia.; Department of Medical Oncology, Royal North Shore Hospital and Mater Hospitals, Sydney, Australia.
Brain O; Translational Gastroenterology Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Gastroenterology, John Radcliffe Hospital, Oxford, UK.
Menzies AM; Melanoma Institute Australia and The University of Sydney, Sydney, Australia.; Department of Medical Oncology, Royal North Shore Hospital and Mater Hospitals, Sydney, Australia.
Kelleher AD; Centre for Applied Medical Research, St Vincent's Hospital, Sydney, Australia.; The Kirby Institute, University of New South Wales, Sydney, Australia.
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Źródło :
Clinical and experimental immunology [Clin Exp Immunol] 2020 Dec; Vol. 202 (3), pp. 335-352. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/pathology
Colitis*/chemically induced
Colitis*/immunology
Colitis*/pathology
Intestinal Mucosa*/immunology
Intestinal Mucosa*/pathology
Mucosal-Associated Invariant T Cells*/immunology
Mucosal-Associated Invariant T Cells*/pathology
T-Lymphocytes, Regulatory*/immunology
T-Lymphocytes, Regulatory*/pathology
Ipilimumab/*adverse effects
Nivolumab/*adverse effects
Adult ; Aged ; Female ; Flow Cytometry ; Humans ; Ipilimumab/administration & dosage ; Male ; Middle Aged ; Nivolumab/administration & dosage
Czasopismo naukowe
Tytuł :
Rab6 regulates recycling and retrograde trafficking of MR1 molecules.
Autorzy :
Huber ME; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA.
Kurapova R; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
Heisler CM; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
Karamooz E; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.; VA Portland Health Care System, 3710 SW US Veterans Hospital Rd, R&D11, Portland, OR, 97239, USA.
Tafesse FG; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA.
Harriff MJ; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA. .; VA Portland Health Care System, 3710 SW US Veterans Hospital Rd, R&D11, Portland, OR, 97239, USA. .; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 27; Vol. 10 (1), pp. 20778. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Histocompatibility Antigens Class I/*metabolism
Minor Histocompatibility Antigens/*metabolism
Mucosal-Associated Invariant T Cells/*immunology
rab GTP-Binding Proteins/*metabolism
Adult ; Antigen Presentation ; Cell Line ; Cell Membrane/immunology ; Cell Membrane/metabolism ; Endosomes/immunology ; Endosomes/metabolism ; Gene Silencing ; Histocompatibility Antigens Class I/genetics ; Humans ; Immunity, Innate ; In Vitro Techniques ; Kinetics ; Ligands ; Minor Histocompatibility Antigens/genetics ; Mucosal-Associated Invariant T Cells/metabolism ; Mucosal-Associated Invariant T Cells/microbiology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Promoter Regions, Genetic ; Protein Transport ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/immunology ; trans-Golgi Network/immunology ; trans-Golgi Network/metabolism
Czasopismo naukowe
Tytuł :
Successful direct-acting antiviral therapy improves circulating mucosal-associated invariant T cells in patients with chronic HCV infection.
Autorzy :
Khlaiphuengsin A; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chuaypen N; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Sodsai P; Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Reantragoon R; Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Han WM; HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
Avihingsanon A; HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
Tangkijvanich P; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
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Źródło :
PloS one [PLoS One] 2020 Dec 31; Vol. 15 (12), pp. e0244112. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*administration & dosage
Benzofurans/*administration & dosage
Hepacivirus/*immunology
Hepatitis C, Chronic/*drug therapy
Hepatitis C, Chronic/*immunology
Imidazoles/*administration & dosage
Mucosal-Associated Invariant T Cells/*immunology
Quinoxalines/*administration & dosage
Adult ; Drug Combinations ; Female ; Hepacivirus/metabolism ; Hepatitis C, Chronic/blood ; Humans ; Male ; Middle Aged ; Mucosal-Associated Invariant T Cells/metabolism
Czasopismo naukowe
Tytuł :
Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
Autorzy :
Priya R; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
Brutkiewicz RR; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2020 Dec 15; Vol. 349, pp. 577428. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Brain/*metabolism
Histocompatibility Antigens Class I/*biosynthesis
Immunity, Innate/*physiology
Microglia/*metabolism
Minor Histocompatibility Antigens/*biosynthesis
Mucosal-Associated Invariant T Cells/*metabolism
Animals ; Astrocytes/immunology ; Brain/immunology ; Cell Line ; Female ; Histocompatibility Antigens Class I/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/immunology ; Minor Histocompatibility Antigens/immunology ; Mucosal-Associated Invariant T Cells/immunology
Czasopismo naukowe
Tytuł :
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
Autorzy :
Jouan Y; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.; Service de chirurgie cardiaque et de réanimation chirurgicale cardio-vasculaire, Centre Hospitalier Régional Universitaire, Tours, France.
Guillon A; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Gonzalez L; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Perez Y; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Boisseau C; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Ehrmann S; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Ferreira M; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de pneumologie, Centre Hospitalier Régional Universitaire, Tours, France.
Daix T; Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
Jeannet R; Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
François B; Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
Dequin PF; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Si-Tahar M; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Baranek T; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Paget C; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 Dec 07; Vol. 217 (12).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phenotype*
Betacoronavirus/*genetics
Coronavirus Infections/*immunology
Mucosal-Associated Invariant T Cells/*metabolism
Natural Killer T-Cells/*metabolism
Pneumonia, Viral/*immunology
Receptors, Antigen, T-Cell, gamma-delta/*metabolism
Respiratory Distress Syndrome/*immunology
Aged ; Antigens, CD/blood ; Antigens, Differentiation, T-Lymphocyte/blood ; COVID-19 ; Cells, Cultured ; Coronavirus Infections/virology ; Cytokines/metabolism ; Female ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Lectins, C-Type/blood ; Male ; Middle Aged ; Mucosal-Associated Invariant T Cells/immunology ; Natural Killer T-Cells/immunology ; Pandemics ; Pneumonia, Viral/virology ; Prognosis ; Prospective Studies ; Respiratory Distress Syndrome/virology ; SARS-CoV-2 ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
MAIT cells, their biological and medical significance.
Autorzy :
Buc M
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Transliterated Title :
MAIT-bunky - ich biologický a medicínsky význam.
Źródło :
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne [Epidemiol Mikrobiol Imunol] 2020 Winter; Vol. 69 (4), pp. 189-193.
Typ publikacji :
Journal Article
MeSH Terms :
Mucosal-Associated Invariant T Cells*/immunology
Humans ; Minor Histocompatibility Antigens
Czasopismo naukowe
Tytuł :
MR1-restricted T cells: the new dawn of cancer immunotherapy.
Autorzy :
Wang Z; Department of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen 518000, China.; Department of Hematology and BMT Center, Chinese PLA General Hospital, Beijing 100853, China.
Wang M; Department of Hematology and BMT Center, Chinese PLA General Hospital, Beijing 100853, China.
Chen J; Department of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen 518000, China.
Zhang L; Department of Hematology and BMT Center, Chinese PLA General Hospital, Beijing 100853, China.
Zhang L; Department of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen 518000, China.
Yu L; Department of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen 518000, China.; Department of Hematology and BMT Center, Chinese PLA General Hospital, Beijing 100853, China.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Nov 27; Vol. 40 (11).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunotherapy, Adoptive*
Histocompatibility Antigens Class I/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Minor Histocompatibility Antigens/*immunology
Mucosal-Associated Invariant T Cells/*immunology
Neoplasms/*therapy
T-Lymphocytes/*transplantation
Animals ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/metabolism ; Mucosal-Associated Invariant T Cells/metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Phenotype ; Prognosis ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
When it's good to have MAITs.
Autorzy :
Souter MN; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
McCluskey J; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Corbett AJ; Department of Microbiology & Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
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Źródło :
Immunology and cell biology [Immunol Cell Biol] 2020 Nov; Vol. 98 (10), pp. 798-801. Date of Electronic Publication: 2020 Oct 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Mucosal-Associated Invariant T Cells*
Tuberculosis*
Animals ; Mice ; Vaccination
Czasopismo naukowe
Tytuł :
Hypersensitivities following allergen antigen recognition by unconventional T cells.
Autorzy :
de Lima Moreira M; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.
Souter MNT; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Vic., Australia.
Chen Z; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.
Loh L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
McCluskey J; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.
Pellicci DG; Murdoch Children's Research Institute, Parkville, Vic., Australia.
Eckle SBG; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.
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Źródło :
Allergy [Allergy] 2020 Oct; Vol. 75 (10), pp. 2477-2490. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hypersensitivity*
Mucosal-Associated Invariant T Cells*
Allergens ; Antigen Presentation ; Histocompatibility Antigens Class I ; Humans ; Minor Histocompatibility Antigens
Czasopismo naukowe
Tytuł :
Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans.
Autorzy :
Swarbrick GM; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.; Portland Veterans Administration Healthcare System, Portland, OR, United States.
Gela A; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Cansler ME; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Null MD; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Duncan RB; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Nemes E; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Shey M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Department of Medicine & Wellcome Centre for Infectious Disease Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Nsereko M; Uganda-CWRU Research Collaboration, Kampala, Uganda.
Mayanja-Kizza H; Uganda-CWRU Research Collaboration, Kampala, Uganda.; Department of Medicine, Makerere University, Kampala, Uganda.
Kiguli S; Uganda-CWRU Research Collaboration, Kampala, Uganda.; Department of Paediatrics, Makerere University, Kampala, Uganda.
Koh J; Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, United States.
Hanekom WA; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Hatherill M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Lancioni C; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Lewinsohn DM; Portland Veterans Administration Healthcare System, Portland, OR, United States.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, OR, United States.
Scriba TJ; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Lewinsohn DA; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Sep 16; Vol. 11, pp. 556695. Date of Electronic Publication: 2020 Sep 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mucosal-Associated Invariant T Cells/*immunology
Mucosal-Associated Invariant T Cells/*metabolism
Adolescent ; Child ; Child, Preschool ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Immunophenotyping ; Infant ; Infant, Newborn ; Mucosal-Associated Invariant T Cells/cytology ; Mucous Membrane/immunology ; Mucous Membrane/metabolism ; Mycobacterium bovis/immunology ; Phenotype ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Vaccination
Czasopismo naukowe

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