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Tytuł:
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.
Autorzy:
Liu Z; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Wang F; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Yuan H; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Tian F; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Yang C; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Hu F; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Liu Y; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Tang M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Ping M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Kang C; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Luo T; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 550025, China.
Yang G; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Hu M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Pharmacology Laboratory, Zhongshan Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Zhongshan, 528401, China.
Gao Z; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. .; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China. .; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Li P; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. .; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China. .; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
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Źródło:
BMC biology [BMC Biol] 2024 Feb 05; Vol. 22 (1), pp. 29. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*/genetics
ERG1 Potassium Channel*/genetics
Humans ; Amino Acid Sequence ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Mutation ; Nucleotides, Cyclic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The RyR1 P3528S Substitution Alters Mouse Skeletal Muscle Contractile Properties and RyR1 Ion Channel Gating.
Autorzy:
Thekkedam CG; Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT 2601, Australia.
Dutka TL; Department of Animal, Plant and Soil Sciences, School of Agriculture, Biomedicine and Environment (SABE), La Trobe University, Melbourne, VIC 3086, Australia.
Van der Poel C; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC 3086, Australia.
Burgio G; Division of Genome Sciences and Cancer, John Curtin School of Medical Research, Australian National University, Acton, ACT 2601, Australia.
Dulhunty AF; Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT 2601, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 28; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*
Ryanodine Receptor Calcium Release Channel*/genetics
Animals ; Humans ; Mice ; Cytoplasm ; Muscle Contraction ; Muscle Fibers, Skeletal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Beta-Barrel Channel Response to High Electric Fields: Functional Gating or Reversible Denaturation?
Autorzy:
Nestorovich EM; Department of Biology, The Catholic University of America, Washington, DC 20064, USA.; Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Bezrukov SM; Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 23; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*/physiology
Lipid Bilayers*/metabolism
Ion Channels/metabolism ; Cell Membrane/metabolism ; Electricity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hydrophobic gating in bundle-crossing ion channels: a case study of TRPV4.
Autorzy:
Huang J; Department of Chemistry University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Chen J; Department of Chemistry University of Massachusetts Amherst, Amherst, MA, 01003, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Oct 27; Vol. 6 (1), pp. 1094. Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Ion Channel Gating*/physiology
TRPV Cation Channels*/genetics
Humans ; Mutation ; Protein Structure, Secondary ; Hydrophobic and Hydrophilic Interactions
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Triplin: Mechanistic Basis for Voltage Gating.
Autorzy:
Colombini M; Department of Biology, University of Maryland, College Park, MD 20842, USA.
Liu P; Department of Biology, University of Maryland, College Park, MD 20842, USA.
Dee C; Department of Biology, University of Maryland, College Park, MD 20842, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 14; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*
Porins*/metabolism
Humans ; Thiourea ; Translocation, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
New 'kids' on the voltage-gated proton channel block.
Autorzy:
Korpos É; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Hungary.; MTA-DE Cell Biology and Signalling Research Group, Faculty of Medicine, University of Debrecen, Hungary.
Papp F; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Hungary.
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Źródło:
The FEBS journal [FEBS J] 2023 Feb; Vol. 290 (4), pp. 970-973. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms:
Protons*
Ion Channel Gating*/genetics
Ion Channels/metabolism ; Zinc/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unexpected expansion of the voltage-gated proton channel family.
Autorzy:
Chaves G; Center of Physiology, Pathophysiology and Biophysics, Paracelsus Medical University, Nuremberg, Germany.
Ayuyan AG; Department of Physiology & Biophysics, Rush University, Chicago, IL, USA.
Cherny VV; Department of Physiology & Biophysics, Rush University, Chicago, IL, USA.
Morgan D; Department of Radiation Oncology, University of Kansas Medical Center, MO, USA.
Franzen A; Institute of Biological Information Processing, Molecular and Cellular Physiology (IBI-1), Jülich, Germany.
Fieber L; Department of Marine Biology and Ecology - Rosenstiel School of Marine and Atmospheric Science, Miami, FL, USA.
Nausch L; Center of Physiology, Pathophysiology and Biophysics, Paracelsus Medical University, Nuremberg, Germany.; Department of Agriculture, Food and Nutrition, Institute of Nutrition and Food Supply Management, University of Applied Sciences Weihenstephan-Triesdorf, Freising, Germany.
Derst C; Center of Physiology, Pathophysiology and Biophysics, Paracelsus Medical University, Nuremberg, Germany.
Mahorivska I; Center of Physiology, Pathophysiology and Biophysics, Paracelsus Medical University, Nuremberg, Germany.
Jardin C; Center of Physiology, Pathophysiology and Biophysics, Paracelsus Medical University, Nuremberg, Germany.
DeCoursey TE; Department of Physiology & Biophysics, Rush University, Chicago, IL, USA.
Musset B; Center of Physiology, Pathophysiology and Biophysics, Paracelsus Medical University, Nuremberg, Germany.; Center of Physiology, Pathophysiology and Biophysics, Paracelsus Medical University, Salzburg, Austria.
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Źródło:
The FEBS journal [FEBS J] 2023 Feb; Vol. 290 (4), pp. 1008-1026. Date of Electronic Publication: 2022 Sep 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*/physiology
Protons*
Animals ; Ion Channels/metabolism ; Arginine ; Cytosol/metabolism ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural Mechanism of Ionic Conductivity of the TRPV1 Channel.
Autorzy:
Trofimov YA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia. .; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia. .
Minakov AS; Moscow State University, Moscow, Russia.
Krylov NA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.; National Research University Higher School of Economics, Moscow, Russia.
Efremov RG; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.; National Research University Higher School of Economics, Moscow, Russia.; Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
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Źródło:
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2023 Feb; Vol. 508 (1), pp. 1-5. Date of Electronic Publication: 2023 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*
Ion Channels*/chemistry
Ion Channels*/metabolism
Animals ; Rats ; Molecular Dynamics Simulation ; Ions/metabolism ; Water/chemistry ; TRPV Cation Channels
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Triplin: Functional Probing of Its Structure and the Dynamics of the Voltage-Gating Process.
Autorzy:
Colombini M; Department of Biology, University of Maryland, College Park, MD 20842, USA.
Barnes K; Department of Biology, University of Maryland, College Park, MD 20842, USA.
Chang KT; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Younis MH; Department of Biology, University of Maryland, College Park, MD 20842, USA.
Aguilella VM; Department of Physics, Universitat Jaume 1, 12080 Castellon, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 09; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*
Porins*
Animals ; Thiourea ; Electricity ; Mammals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2 .
Autorzy:
Yin Y; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Zhang F; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Feng S; Departments of Biological Sciences, Chemistry, and Bioengineering, Lehigh University, Bethlehem, PA 18015, USA.
Butay KJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Borgnia MJ; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Im W; Departments of Biological Sciences, Chemistry, and Bioengineering, Lehigh University, Bethlehem, PA 18015, USA.
Lee SY; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Oct 14; Vol. 378 (6616), pp. eadd1268. Date of Electronic Publication: 2022 Oct 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cold Temperature*
TRPM Cation Channels*/agonists
TRPM Cation Channels*/chemistry
Phosphatidylinositol 4,5-Diphosphate*/chemistry
Phosphatidylinositol 4,5-Diphosphate*/pharmacology
Thermosensing*/drug effects
Thermosensing*/physiology
Ion Channel Gating*/drug effects
Ion Channel Gating*/physiology
Pyrimidinones*/chemistry
Pyrimidinones*/pharmacology
Animals ; Mice ; Cryoelectron Microscopy ; Ligands ; Menthol/chemistry ; Menthol/pharmacology ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring the Impact of BK Ca Channel Function in Cellular Membranes on Cardiac Electrical Activity.
Autorzy:
Chen YC; Division of Cardiovascular Surgery, Department of Surgery, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
Shih CL; Clinical Research Center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60056, Taiwan.
Wu CL; Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
Fang YH; Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
So EC; Department of Anesthesia, An Nan Hospital, China Medical University, Tainan 70965, Taiwan.
Wu SN; Department of Research and Education, An Nan Hospital, China Medical University, Tainan 70965, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung 80421, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Myocytes, Cardiac*/metabolism
Fibroblasts*/metabolism
Animals ; Cell Membrane/metabolism ; Cells, Cultured ; Ion Channel Gating ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Calcium/metabolism ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multiple mechanisms contribute to fluorometry signals from the voltage-gated proton channel.
Autorzy:
Papp F; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary. .
Toombes GES; Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Dr., MSC 3701, Bethesda, MD, 20892-3701, USA.
Pethő Z; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.; Institut für Physiologie II, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Bagosi A; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
Feher A; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
Almássy J; Department of Physiology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
Borrego J; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
Kuki Á; Department of Applied Chemistry, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
Kéki S; Department of Applied Chemistry, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
Panyi G; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
Varga Z; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen, H-4032, Hungary.
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Źródło:
Communications biology [Commun Biol] 2022 Oct 26; Vol. 5 (1), pp. 1131. Date of Electronic Publication: 2022 Oct 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*
Protons*
Ion Channels/metabolism ; Fluorometry ; Amino Acids ; Lipids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating.
Autorzy:
Jaradat R; Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.
Li X; Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.
Chen H; Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.
Stathopulos PB; Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.
Bai D; Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 01; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 01.
Typ publikacji:
Journal Article
MeSH Terms:
Gap Junctions*/genetics
Gap Junctions*/metabolism
Ion Channel Gating*
Connexins/metabolism ; Hydrophobic and Hydrophilic Interactions ; Ion Channels/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism.
Autorzy:
Gazgalis D; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Cantwell L; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Xu Y; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Thakur GA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Cui M; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.; Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Guarnieri F; Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Logothetis DE; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.; Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.; Department of Chemistry and Chemical Biology, College of Science, Boston, MA 02115, USA.; Roux Institute, Northeastern University, Portland, ME 04101, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 16; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 16.
Typ publikacji:
Journal Article
MeSH Terms:
G Protein-Coupled Inwardly-Rectifying Potassium Channels*/metabolism
Ion Channel Gating*/physiology
GTP-Binding Proteins/metabolism ; Lipid Bilayers ; Phosphates/metabolism ; Phosphatidylinositols ; Urea
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity.
Autorzy:
Gasparri F; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Sarkar D; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Bielickaite S; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Poulsen MH; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Hauser AS; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Jul; Vol. 179 (14), pp. 3859-3874. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*
Mutation, Missense*
Receptors, Purinergic P2X2*/genetics
Adenosine Triphosphate/metabolism ; Humans ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extracellular Cysteines Are Critical to Form Functional Cx46 Hemichannels.
Autorzy:
Fernández-Olivares A; Programa de Comunicación Celular en Cáncer, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7780272, Chile.
Durán-Jara E; Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7780272, Chile.
Verdugo DA; Laboratorio de Neurobiología, Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 7780272, Chile.
Fiori MC; Department of Cell Physiology and Molecular Biophysics and Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430-6551, USA.
Altenberg GA; Department of Cell Physiology and Molecular Biophysics and Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430-6551, USA.
Stehberg J; Laboratorio de Neurobiología, Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 7780272, Chile.
Alfaro I; Programa de Comunicación Celular en Cáncer, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7780272, Chile.; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Santiago 7690000, Chile.
Calderón JF; Centro de Genética y Genómica, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7780272, Chile.
Retamal MA; Programa de Comunicación Celular en Cáncer, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7780272, Chile.; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Santiago 7690000, Chile.; Centro de Fisiología Celular e Integrativa, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7690000, Chile.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 29; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 29.
Typ publikacji:
Journal Article
MeSH Terms:
Gap Junctions*/metabolism
Ion Channel Gating*
Connexins/metabolism ; Cysteine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell glycosaminoglycans content modulates human voltage-gated proton channel (H V 1) gating.
Autorzy:
Orts DJB; Departamento de Biofísica, Laboratório de Neurobiologia Estrutural e Funcional (LaNEF), Universidade Federal de São Paulo - UNIFESP, Brasil.
Arcisio-Miranda M; Departamento de Biofísica, Laboratório de Neurobiologia Estrutural e Funcional (LaNEF), Universidade Federal de São Paulo - UNIFESP, Brasil.
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Źródło:
The FEBS journal [FEBS J] 2022 May; Vol. 289 (9), pp. 2593-2612. Date of Electronic Publication: 2021 Nov 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*/physiology
Protons*
Animals ; CHO Cells ; Chondroitin Sulfates ; Cricetinae ; Cricetulus ; Glycosaminoglycans ; Heparitin Sulfate ; Humans ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recent Developments in Ion Channel and Ion-Related Signaling.
Autorzy:
Ohya S; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 22; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 22.
Typ publikacji:
Editorial
MeSH Terms:
Ion Channels*/metabolism
Channelopathies*
Humans ; Ion Channel Gating/physiology ; Signal Transduction ; Heart
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.
Autorzy:
Zhou Z; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Ma X; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Lin Y; Research School of Biology, Australian National University, Acton, ACT 2601, Australia.
Cheng D; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Bavi N; Department of Biochemistry and Molecular Biophysics, University of Chicago, Chicago, IL 60637, USA.
Secker GA; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5001, Australia.
Li JV; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Janbandhu V; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Sutton DL; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5001, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005 Australia.
Scott HS; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5001, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005 Australia.; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA 5000, Australia.
Yao M; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Harvey RP; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.; School of Biotechnology and Biomolecular Science, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
Harvey NL; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5001, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005 Australia.
Corry B; Research School of Biology, Australian National University, Acton, ACT 2601, Australia.
Zhang Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Cox CD; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Aug 18; Vol. 381 (6659), pp. 799-804. Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channels*/chemistry
Ion Channels*/genetics
Ion Channels*/metabolism
Myogenic Regulatory Factors*/chemistry
Myogenic Regulatory Factors*/genetics
Myogenic Regulatory Factors*/metabolism
Humans ; Cryoelectron Microscopy ; HEK293 Cells ; Ion Channel Gating ; Kinetics ; Lymphatic Diseases/genetics ; Mutation ; Protein Domains ; Myoblasts/metabolism ; Animals ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A selectivity filter mutation provides insights into gating regulation of a K channel.
Autorzy:
Friesacher T; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria.
Reddy HP; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036, India.
Bernsteiner H; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria.
Carlo Combista J; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
Shalomov B; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
Bera AK; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036, India.
Zangerl-Plessl EM; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria.
Dascal N; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. .; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978, Israel. .
Stary-Weinzinger A; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria. .
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Źródło:
Communications biology [Commun Biol] 2022 Apr 11; Vol. 5 (1), pp. 345. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G Protein-Coupled Inwardly-Rectifying Potassium Channels*/chemistry
G Protein-Coupled Inwardly-Rectifying Potassium Channels*/genetics
G Protein-Coupled Inwardly-Rectifying Potassium Channels*/metabolism
Ion Channel Gating*
Binding Sites ; Humans ; Mutation ; Potassium/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1954

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