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Tytuł:
Role of High Voltage-Gated Ca Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function.
Autorzy:
Tuluc P; Centre for Molecular Biosciences, Department of Pharmacology and Toxicology, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Theiner T; Centre for Molecular Biosciences, Department of Pharmacology and Toxicology, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Jacobo-Piqueras N; Centre for Molecular Biosciences, Department of Pharmacology and Toxicology, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Geisler SM; Centre for Molecular Biosciences, Department of Pharmacology and Toxicology, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
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Źródło:
Cells [Cells] 2021 Aug 06; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Calcium Signaling*
Ion Channel Gating*
Blood Glucose/*metabolism
Calcium Channels/*metabolism
Diabetes Mellitus/*metabolism
Insulin/*metabolism
Insulin-Secreting Cells/*metabolism
Animals ; Calcium Channels/genetics ; Diabetes Mellitus/blood ; Diabetes Mellitus/genetics ; Diabetes Mellitus/pathology ; Exocytosis ; Humans ; Insulin-Secreting Cells/pathology ; Membrane Potentials ; Secretory Pathway
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca Channels Alter the Pharmacology of I CRAC .
Autorzy:
Kappel S; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Kilch T; Auf der Schled 19, 66822 Lebach, Germany.
Baur R; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Lochner M; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Peinelt C; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 02; Vol. 21 (7). Date of Electronic Publication: 2020 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Ion Channel Gating*/drug effects
Protein Multimerization*/drug effects
Calcium Channels/*metabolism
Calcium Channels/chemistry ; Cell Line, Tumor ; Humans ; Male ; Membrane Potentials ; ORAI1 Protein/chemistry ; ORAI1 Protein/metabolism ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels.
Autorzy:
Gambeta E; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Gandini MA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Souza IA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Ferron L; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Zamponi GW; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada. .
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Źródło:
Molecular brain [Mol Brain] 2021 Jan 07; Vol. 14 (1), pp. 4. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Association Studies*
Genetic Predisposition to Disease*
Genetic Variation*
Calcium Channels/*genetics
Ion Channel Gating/*genetics
Trigeminal Neuralgia/*genetics
Cell Line ; Humans ; Mutation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of lipophilic two-pore channel agonists.
Autorzy:
Gerndt S; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.
Krogsaeter E; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
Patel S; Department of Cell and Developmental Biology, University College London, London, UK.
Bracher F; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.
Grimm C; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
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Źródło:
The FEBS journal [FEBS J] 2020 Dec; Vol. 287 (24), pp. 5284-5293. Date of Electronic Publication: 2020 Jun 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Calcium Signaling*
Drug Discovery*
Calcium Channels/*chemistry
Ion Channel Gating/*drug effects
Small Molecule Libraries/*pharmacology
Transient Receptor Potential Channels/*agonists
Animals ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells.
Autorzy:
Montefusco F; Department of Information Engineering, University of Padova, 35131 Padova, Italy.
Pedersen MG; Department of Information Engineering, University of Padova, 35131 Padova, Italy.; Department of Mathematics 'Tullio Levi-Civita', University of Padova, 35131 Padova, Italy.; Padova Neuroscience Center, University of Padova, 35131 Padova, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Nov 30; Vol. 20 (23). Date of Electronic Publication: 2019 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Action Potentials/*physiology
Calcium/*metabolism
Calcium Channels/*metabolism
Exocytosis/*physiology
Large-Conductance Calcium-Activated Potassium Channels/*metabolism
Somatotrophs/*metabolism
Animals ; Computer Simulation ; Cytoplasmic Granules/chemistry ; Cytoplasmic Granules/metabolism ; Humans ; Ion Channel Gating/physiology ; Kinetics ; Models, Biological ; Pituitary Gland/cytology ; Pituitary Gland/metabolism ; Somatotrophs/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.
Autorzy:
Andrade A; Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA. .
Brennecke A; Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA.
Mallat S; Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA.
Brown J; Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA.
Gomez-Rivadeneira J; Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA.
Czepiel N; Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA.
Londrigan L; Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 19; Vol. 20 (14). Date of Electronic Publication: 2019 Jul 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Calcium Channels/*genetics
Mental Disorders/*genetics
Animals ; Biomarkers ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Calcium Channels/chemistry ; Calcium Channels/metabolism ; Clinical Trials as Topic ; Gene Expression Regulation ; Humans ; Ion Channel Gating/drug effects ; Mental Disorders/diagnosis ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Molecular Targeted Therapy ; Protein Binding ; Protein Interaction Domains and Motifs ; Structure-Activity Relationship ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular understanding of calcium permeation through the open Orai channel.
Autorzy:
Liu X; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Wu G; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Yu Y; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Chen X; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Ji R; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Lu J; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Li X; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Zhang X; School of Medicine, Zhejiang University, Hangzhou, China.
Yang X; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Shen Y; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.; Synergetic Innovation Center of Chemical Science and Engineering, Tianjin, China.
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Źródło:
PLoS biology [PLoS Biol] 2019 Apr 22; Vol. 17 (4), pp. e3000096. Date of Electronic Publication: 2019 Apr 22 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium/*metabolism
Calcium Channels/*metabolism
Drosophila Proteins/*metabolism
ORAI1 Protein/*metabolism
Animals ; Calcium/physiology ; Cell Membrane/metabolism ; Cryoelectron Microscopy ; Drosophila Proteins/genetics ; Drosophila melanogaster/metabolism ; Ion Channel Gating/physiology ; Membrane Proteins/metabolism ; ORAI1 Protein/genetics ; Protein Structure, Secondary
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.
Autorzy:
Kashio M; Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.; Department of Physiology, Aichi Medical University, Nagakute, 480-1195, Japan.
Wei-Qi G; Department of Anatomy and Physiology, Saga University, Saga, 849-8501, Japan.
Ohsaki Y; Department of Anatomy and Physiology, Saga University, Saga, 849-8501, Japan.
Kido MA; Department of Anatomy and Physiology, Saga University, Saga, 849-8501, Japan.
Taruno A; Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. .; JST, PRESTO, Kawaguchi, Saitama, 332-0012, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2019 Feb 25; Vol. 9 (1), pp. 2681. Date of Electronic Publication: 2019 Feb 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels/*metabolism
Cell Membrane/*metabolism
Epithelial Cells/*metabolism
Taste Buds/*metabolism
Amino Acid Sequence ; Animals ; Calcium Channels/genetics ; Cell Line, Tumor ; Cell Polarity/genetics ; Cells, Cultured ; Dogs ; Humans ; Ion Channel Gating/genetics ; Madin Darby Canine Kidney Cells ; Mice, Knockout ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Sequence Homology, Amino Acid ; Synaptic Transmission/genetics ; Taste Buds/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium-dependent inactivation.
Autorzy:
Chen P; Key Laboratory for Biomedical Engineering of Ministry of Education of China, Department of Biomedical Engineering, School of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Wu JZ
Zhao J
Wang P
Luo J
Yang W
Liu XD
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Źródło:
European biophysics journal : EBJ [Eur Biophys J] 2015 Sep; Vol. 44 (6), pp. 483-92. Date of Electronic Publication: 2015 Jun 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*
Calcium Channels/*chemistry
Ion Channels/*chemistry
Receptors, Cell Surface/*chemistry
Alkalies/metabolism ; Calcium/metabolism ; Calcium Channels/metabolism ; HEK293 Cells ; Humans ; Ion Channels/metabolism ; Protein Binding ; Receptors, Cell Surface/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients.
Autorzy:
Wang CY; Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lai MD; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Phan NN; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh, Vietnam.
Sun Z; Department of Radiology, University of California San Francisco, San Francisco, California, United States of America.
Lin YC; Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan.
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Źródło:
PloS one [PLoS One] 2015 Jul 06; Vol. 10 (7), pp. e0125766. Date of Electronic Publication: 2015 Jul 06 (Print Publication: 2015).
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms:
Datasets as Topic*
Ion Channel Gating*
Calcium Channels/*genetics
Neoplasms/*genetics
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Butanol isomers exert distinct effects on voltage-gated calcium channel currents and thus catecholamine secretion in adrenal chromaffin cells.
Autorzy:
McDavid S; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Bauer MB; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Brindley RL; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Jewell ML; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Currie KP; Department of Anesthesiology, Department of Pharmacology, and Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Oct 02; Vol. 9 (10), pp. e109203. Date of Electronic Publication: 2014 Oct 02 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Ion Channel Gating*
Butanols/*pharmacology
Calcium Channels/*drug effects
Catecholamines/*metabolism
Chromaffin Cells/*drug effects
Animals ; Butanols/chemistry ; Calcium/metabolism ; Cattle ; Chromaffin Cells/metabolism ; Isomerism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
On the structure and mechanism of two-pore channels.
Autorzy:
Kintzer AF; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Stroud RM; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
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Źródło:
The FEBS journal [FEBS J] 2018 Jan; Vol. 285 (2), pp. 233-243. Date of Electronic Publication: 2017 Jul 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Arabidopsis/*metabolism
Arabidopsis Proteins/*chemistry
Arabidopsis Proteins/*physiology
Calcium Channels/*chemistry
Calcium Channels/*physiology
Animals ; Arabidopsis Proteins/antagonists & inhibitors ; Arabidopsis Proteins/metabolism ; Calcium Channels/metabolism ; Calcium Signaling ; Crystallography, X-Ray ; Endosomes/metabolism ; Humans ; Ion Channel Gating ; Ion Transport ; Lysosomes/metabolism ; Phosphorylation ; Phosphotransferases/metabolism ; Protein Binding ; Protein Conformation ; Virus Diseases/prevention & control
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.
Autorzy:
Tang L; 1] Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA [2] Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA [3].
Gamal El-Din TM; 1] Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA [2].
Payandeh J; 1] Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA [2] Department of Structural Biology, Genentech Inc., South San Francisco, California 94080, USA.
Martinez GQ; Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
Heard TM; Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
Scheuer T; Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
Zheng N; 1] Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA [2] Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.
Catterall WA; Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
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Źródło:
Nature [Nature] 2014 Jan 02; Vol. 505 (7481), pp. 56-61. Date of Electronic Publication: 2013 Nov 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Calcium Channels/*chemistry
Calcium Channels/*metabolism
Bacterial Proteins/genetics ; Binding Sites ; Biocatalysis ; Calcium/metabolism ; Calcium Channels/genetics ; Cations, Divalent/metabolism ; Crystallography, X-Ray ; Electric Conductivity ; Models, Biological ; Models, Molecular ; Structure-Activity Relationship ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels.
Autorzy:
Ermolyuk YS; UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, United Kingdom.
Alder FG; UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, United Kingdom.
Surges R; UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, United Kingdom.
Pavlov IY; UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, United Kingdom.
Timofeeva Y; Department of Computer Science, University of Warwick, Coventry, CV4 7AL, United Kingdom.; Centre for Complexity Science, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Kullmann DM; UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, United Kingdom.
Volynski KE; UCL Institute of Neurology, University College London, Queen Square, WC1N 3BG, United Kingdom.
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Źródło:
Nature neuroscience [Nat Neurosci] 2013 Dec; Vol. 16 (12), pp. 1754-1763. Date of Electronic Publication: 2013 Nov 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels/*classification
Calcium Channels/*physiology
Glutamic Acid/*metabolism
Ion Channel Gating/*physiology
Neurons/*metabolism
Animals ; Animals, Newborn ; Calcium/metabolism ; Calcium Channel Agonists/pharmacology ; Calcium Channel Blockers ; Cells, Cultured ; Chelating Agents/pharmacology ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Electric Stimulation ; Excitatory Postsynaptic Potentials/drug effects ; Hippocampus/cytology ; Ion Channel Gating/drug effects ; Models, Biological ; Neurons/drug effects ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Stochastic Processes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Sensitization of TRPA1 by Protein Kinase A.
Autorzy:
Meents JE; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.; Institute of Physiology, Uniklinik RWTH Aachen, Aachen, Germany.
Fischer MJ; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.; Institute of Physiology and Pathophysiology, University of Erlangen-Nuremberg, Erlangen, Germany.; Center for Physiology and Pharmacology, Medical University Wien, Wien, Austria.
McNaughton PA; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.; Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.
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Źródło:
PloS one [PLoS One] 2017 Jan 11; Vol. 12 (1), pp. e0170097. Date of Electronic Publication: 2017 Jan 11 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Calcium Channels/*physiology
Cyclic AMP-Dependent Protein Kinases/*metabolism
Nerve Tissue Proteins/*physiology
Transient Receptor Potential Channels/*physiology
Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium Signaling/drug effects ; Colforsin/pharmacology ; Cyclic AMP-Dependent Protein Kinases/physiology ; Cymenes ; HEK293 Cells ; Humans ; Ion Channel Gating/drug effects ; Ion Channel Gating/genetics ; Monoterpenes/pharmacology ; Mutagenesis, Site-Directed ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Patch-Clamp Techniques ; Phosphorylation/drug effects ; TRPA1 Cation Channel ; Transfection ; Transient Receptor Potential Channels/genetics ; Transient Receptor Potential Channels/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Outer Pore and Selectivity Filter of TRPA1.
Autorzy:
Christensen AP; Program in Neuroscience, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts, United States of America.; Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts, United States of America.
Akyuz N; Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts, United States of America.
Corey DP; Program in Neuroscience, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts, United States of America.; Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Nov 08; Vol. 11 (11), pp. e0166167. Date of Electronic Publication: 2016 Nov 08 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Calcium Channels/*genetics
Nerve Tissue Proteins/*genetics
Transient Receptor Potential Channels/*genetics
Amino Acid Sequence ; Animals ; Aspartic Acid/genetics ; CHO Cells ; Cricetulus ; Glutamic Acid/genetics ; Humans ; Ion Channel Gating/genetics ; Permeability ; Point Mutation/genetics ; TRPA1 Cation Channel
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation.
Autorzy:
Limpitikul WB; Calcium Signals Laboratory, Departments of Biomedical Engineering and Neuroscience, The Johns Hopkins University School of Medicine, Ross Building, Room 713,720 Rutland Avenue, Baltimore, MD 21205, USA.
Dick IE; Calcium Signals Laboratory, Departments of Biomedical Engineering and Neuroscience, The Johns Hopkins University School of Medicine, Ross Building, Room 713,720 Rutland Avenue, Baltimore, MD 21205, USA.
Ben-Johny M; Calcium Signals Laboratory, Departments of Biomedical Engineering and Neuroscience, The Johns Hopkins University School of Medicine, Ross Building, Room 713,720 Rutland Avenue, Baltimore, MD 21205, USA.
Yue DT; Calcium Signals Laboratory, Departments of Biomedical Engineering and Neuroscience, The Johns Hopkins University School of Medicine, Ross Building, Room 713,720 Rutland Avenue, Baltimore, MD 21205, USA.
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Źródło:
Scientific reports [Sci Rep] 2016 Jun 03; Vol. 6, pp. 27235. Date of Electronic Publication: 2016 Jun 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Mutation, Missense*
Autism Spectrum Disorder/*genetics
Calcium/*metabolism
Calcium Channels/*genetics
Calcium Channels, L-Type/*genetics
Animals ; Autism Spectrum Disorder/metabolism ; Calcium Channels/metabolism ; Calcium Channels, L-Type/metabolism ; Down-Regulation ; HEK293 Cells ; Homeostasis ; Humans ; Ion Channel Gating ; Membrane Potentials ; Models, Animal ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Selective activation of KCa3.1 and CRAC channels by P2Y2 receptors promotes Ca(2+) signaling, store refilling and migration of rat microglial cells.
Autorzy:
Ferreira R; Genes and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.
Schlichter LC
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Źródło:
PloS one [PLoS One] 2013 Apr 19; Vol. 8 (4), pp. e62345. Date of Electronic Publication: 2013 Apr 19 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Signaling*/drug effects
Cell Movement*/drug effects
Ion Channel Gating*/drug effects
Calcium Channels/*metabolism
Intermediate-Conductance Calcium-Activated Potassium Channels/*metabolism
Microglia/*cytology
Receptors, Purinergic P2Y2/*metabolism
Animals ; Cell Line ; Intracellular Space/drug effects ; Intracellular Space/metabolism ; Microglia/drug effects ; Microglia/metabolism ; ORAI1 Protein ; Rats ; Uridine Triphosphate/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gated regulation of CRAC channel ion selectivity by STIM1.
Autorzy:
McNally BA; Department of Molecular Pharmacology and Biological Chemistry, Northwestern University School of Medicine, 303 E Chicago Avenue, Ward 8-296, Chicago, Illinois 60611, USA.
Somasundaram A
Yamashita M
Prakriya M
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Źródło:
Nature [Nature] 2012 Jan 25; Vol. 482 (7384), pp. 241-5. Date of Electronic Publication: 2012 Jan 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*
Calcium Channels/*metabolism
Membrane Proteins/*metabolism
Neoplasm Proteins/*metabolism
Calcium Channels/chemistry ; Calcium Channels/genetics ; HEK293 Cells ; Humans ; Membrane Proteins/chemistry ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Models, Molecular ; Mutation/genetics ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/deficiency ; Neoplasm Proteins/genetics ; ORAI1 Protein ; Stromal Interaction Molecule 1 ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation.
Autorzy:
Semenov A; Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland.
Möykkynen T
Coleman SK
Korpi ER
Keinänen K
Pokaż więcej
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (11), pp. e49282. Date of Electronic Publication: 2012 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ion Channel Gating*
Protein Conformation*
Calcium Channels/*metabolism
Multiprotein Complexes/*metabolism
Receptors, AMPA/*metabolism
Animals ; Calcium Channels/genetics ; Dose-Response Relationship, Drug ; Glutamic Acid/metabolism ; HEK293 Cells ; Humans ; Immunoblotting ; Immunoprecipitation ; Multiprotein Complexes/genetics ; Patch-Clamp Techniques ; Rats ; Receptors, AMPA/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 136

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