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Tytuł :
Novel Nontoxic 5,9-Disubstituted SN38 Derivatives: Characterization of Their Pharmacological Properties and Interactions with DNA Oligomers.
Autorzy :
Bednarek E; Falsified Medicines and Medical Devices Department, National Medicines Institute, 00-725 Warsaw, Poland.
Bocian W; Falsified Medicines and Medical Devices Department, National Medicines Institute, 00-725 Warsaw, Poland.
Urbanowicz M; Falsified Medicines and Medical Devices Department, National Medicines Institute, 00-725 Warsaw, Poland.
Sitkowski J; Falsified Medicines and Medical Devices Department, National Medicines Institute, 00-725 Warsaw, Poland.
Naumczuk B; Falsified Medicines and Medical Devices Department, National Medicines Institute, 00-725 Warsaw, Poland.; Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.
Kozerski L; Falsified Medicines and Medical Devices Department, National Medicines Institute, 00-725 Warsaw, Poland.; Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 30; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Antineoplastic Agents/*chemistry
DNA/*chemistry
Irinotecan/*analogs & derivatives
Topoisomerase I Inhibitors/*chemistry
Antineoplastic Agents/toxicity ; Irinotecan/toxicity ; Topoisomerase I Inhibitors/toxicity
Czasopismo naukowe
Tytuł :
Metronomic Maintenance With Weekly Vinblastine After Induction With Bevacizumab-Irinotecan in Children With Low-grade Glioma Prevents Early Relapse.
Autorzy :
Roux C; Departments of Pediatric Hematology, Immunology and Oncology.
Revon-Rivière G; Departments of Pediatric Hematology, Immunology and Oncology.
Gentet JC; Departments of Pediatric Hematology, Immunology and Oncology.
Verschuur A; Departments of Pediatric Hematology, Immunology and Oncology.; Metronomics Global Health Initiative.
Scavarda D; Pediatric Neurosurgery.
Saultier P; Departments of Pediatric Hematology, Immunology and Oncology.; C2VN, INSERM, INRAe, Aix Marseille University.
Appay R; Pathology.
Padovani L; Radiotherapy Department, La Timone Children's University Hospital, AP-HM.
André N; Departments of Pediatric Hematology, Immunology and Oncology.; Metronomics Global Health Initiative.; SMARTc unit Centre de Recherche en Cancérologie de Marseille Inserm U1068, Aix Marseille University, Marseille, France.
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Źródło :
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2021 Jul 01; Vol. 43 (5), pp. e630-e634.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Bevacizumab/*therapeutic use
Brain Neoplasms/*drug therapy
Glioma/*drug therapy
Irinotecan/*therapeutic use
Vinblastine/*therapeutic use
Administration, Metronomic ; Adolescent ; Antineoplastic Agents/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bevacizumab/administration & dosage ; Brain Neoplasms/pathology ; Child ; Child, Preschool ; Female ; Glioma/pathology ; Humans ; Irinotecan/administration & dosage ; Male ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; Retrospective Studies ; Vinblastine/administration & dosage
Czasopismo naukowe
Tytuł :
A novel irinotecan-lipiodol nanoemulsion for intravascular administration: pharmacokinetics and biodistribution in the normal and tumor bearing rat liver.
Autorzy :
Melancon MP; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA.
Yevich S; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Avritscher R; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Swigost A; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Medstar Georgetown University Hospital, Washington Hospital Center, Washington, DC, USA.
Lu L; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.
Tian L; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Damasco JA; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dixon K; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cortes AC; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Munoz NM; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Liang D; College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.
Liu D; The University of British Columbia, Vancouver, Canada.
Tam AL; Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 240-251.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatic Artery*
Portal Vein*
Colorectal Neoplasms/*pathology
Ethiodized Oil/*pharmacokinetics
Irinotecan/*pharmacokinetics
Liver/*metabolism
Liver Neoplasms/*secondary
Topoisomerase I Inhibitors/*pharmacokinetics
Animals ; Cell Line, Tumor ; Chemoembolization, Therapeutic/methods ; Drug Carriers ; Emulsions/pharmacokinetics ; In Vitro Techniques ; Irinotecan/administration & dosage ; Liver Neoplasms/therapy ; Nanostructures ; Prodrugs/administration & dosage ; Prodrugs/pharmacokinetics ; Rats ; Topoisomerase I Inhibitors/administration & dosage
Czasopismo naukowe
Tytuł :
Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle.
Autorzy :
Yang TC; Department of Neurosurgery, School of Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Liu SJ; Department of Mechanical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.; Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkou, Taoyuan 33302, Taiwan.
Lo WL; Division of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Chen SM; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.; Department of Neurosurgery, Taipei Medical University Hospital, Taipei 110301, Taiwan.
Tang YL; Department of Mechanical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.
Tseng YY; Division of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 24; Vol. 22 (11). Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Brain Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Glioblastoma/*drug therapy
Irinotecan/*pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry
Temozolomide/*pharmacology
Animals ; Apoptosis/drug effects ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Delivery Systems ; Drug Liberation ; Glioblastoma/mortality ; Glioblastoma/pathology ; Humans ; Irinotecan/adverse effects ; Mice ; Microplastics/chemistry ; Microscopy, Electron, Scanning ; Rats ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
"Sweet tooth"-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy.
Autorzy :
Ding N; Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310020, China. .
Xu S
Zheng S
Ye Q
Xu L
Ling S
Xie S
Chen W
Zhang Z
Xue M
Lin Z
Xu X
Wang L
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2021 Mar 28; Vol. 9 (12), pp. 2816-2830. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Delivery Systems*
Antineoplastic Agents/*pharmacology
Irinotecan/*pharmacology
Nanoparticles/*chemistry
Prodrugs/*pharmacology
Stomach Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Drug Liberation ; Drug Screening Assays, Antitumor ; Humans ; Irinotecan/chemical synthesis ; Irinotecan/chemistry ; Kinetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Stomach Neoplasms/pathology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
An analytical "quality by design" approach in RP-HPLC method development and validation for reliable and rapid estimation of irinotecan in an injectable formulation.
Autorzy :
Bhaskaran NA; Department of Pharmaceutics Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Udupi Karnataka, India.
Kumar L; Department of Pharmaceutics Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Udupi Karnataka, India.
Reddy MS; Department of Pharmaceutics Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Udupi Karnataka, India.
Pai GK; Department of Pharmaceutics Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Udupi Karnataka, India.
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Źródło :
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2021 Mar 01; Vol. 71 (1), pp. 57-79.
Typ publikacji :
Journal Article
MeSH Terms :
Irinotecan/*analysis
Chromatography, High Pressure Liquid ; Chromatography, Reverse-Phase ; Drug Compounding ; Indicators and Reagents ; Injections ; Irinotecan/administration & dosage ; Limit of Detection ; Quality Control ; Reproducibility of Results ; Software ; Spectrophotometry, Ultraviolet
Czasopismo naukowe
Tytuł :
The introduction of immunosuppressor (TDO inhibitor) significantly improved the efficacy of irinotecan in treating hepatocellular carcinoma.
Autorzy :
Liu Q; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China.; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Hua S; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China.; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Wang X; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China.; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Chen F; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China. .; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. .
Gou S; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China. .; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Feb; Vol. 70 (2), pp. 497-508. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*drug therapy
Immunotherapy/*methods
Irinotecan/*therapeutic use
Liver Neoplasms/*drug therapy
Topoisomerase I Inhibitors/*therapeutic use
Animals ; Humans ; Irinotecan/pharmacology ; Mice ; Topoisomerase I Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
A PEGylated alternating copolymeric prodrug of sulfur dioxide with glutathione responsiveness for Irinotecan delivery.
Autorzy :
Zhang Y; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. .
Zhang H
He P
Yi X
Liu X
Xiao C
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2021 Jan 07; Vol. 9 (1), pp. 187-194. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Delivery Systems/*methods
Glutathione/*chemical synthesis
Irinotecan/*chemical synthesis
Polyethylene Glycols/*chemical synthesis
Prodrugs/*chemical synthesis
Sulfur Dioxide/*chemical synthesis
Dose-Response Relationship, Drug ; Glutathione/administration & dosage ; Glutathione/metabolism ; Hep G2 Cells ; Humans ; Irinotecan/administration & dosage ; Irinotecan/metabolism ; Nuclear Magnetic Resonance, Biomolecular/methods ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/metabolism ; Polymers/administration & dosage ; Polymers/chemical synthesis ; Polymers/metabolism ; Prodrugs/administration & dosage ; Prodrugs/metabolism ; Sulfur Dioxide/administration & dosage ; Sulfur Dioxide/metabolism
Czasopismo naukowe
Tytuł :
Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer.
Autorzy :
Vitiello PP; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Martini G; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Mele L; Department of Experimental Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Giunta EF; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
De Falco V; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Ciardiello D; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Belli V; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Cardone C; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Matrone N; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Poliero L; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Tirino V; Department of Experimental Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Napolitano S; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Della Corte C; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Selvaggi F; Department of Medical, Surgical, General and oncology surgery, Neurologic, Metabolic and Ageing Sciences, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Papaccio G; Department of Experimental Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Troiani T; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Morgillo F; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Desiderio V; Department of Experimental Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Ciardiello F; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy.
Martinelli E; Department of Precision Medicine, Medical Oncology, Università degli Studi della Campania Luigi Vanvitelli, Naples, Campania, Italy. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Jan 06; Vol. 40 (1), pp. 15. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Colorectal Neoplasms/*drug therapy
Indazoles/*therapeutic use
Irinotecan/*therapeutic use
Piperidines/*therapeutic use
Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Cell Line, Tumor ; Female ; Humans ; Indazoles/pharmacology ; Irinotecan/pharmacology ; Mice ; Mice, Nude ; Mutation ; Piperidines/pharmacology
Czasopismo naukowe
Tytuł :
Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity.
Autorzy :
Lin HY; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Department of Chemistry, National Taiwan University, Taipei, Taiwan.
Chen CY; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Department of Chemistry, National Taiwan University, Taipei, Taiwan.
Lin TC; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Department of Chemistry, National Taiwan University, Taipei, Taiwan.
Yeh LF; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Hsieh WC; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Gao S; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Burnouf PA; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chen BM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Hsieh TJ; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Dashnyam P; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Kuo YH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Tu Z; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Roffler SR; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. .; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. .
Lin CH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan. .; Department of Chemistry, National Taiwan University, Taipei, Taiwan. .; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan. .; The Genomics Research Center, Academia Sinica, Taipei, Taiwan. .
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Źródło :
Communications biology [Commun Biol] 2021 Mar 04; Vol. 4 (1), pp. 280. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Irinotecan*
Bacteria/*drug effects
Colon/*microbiology
Diarrhea/*prevention & control
Enzyme Inhibitors/*pharmacology
Gastrointestinal Microbiome/*drug effects
Glucuronidase/*antagonists & inhibitors
Imino Pyranoses/*pharmacology
Uronic Acids/*pharmacology
Animals ; Bacteria/enzymology ; Cell Line ; Diarrhea/chemically induced ; Diarrhea/microbiology ; Disease Models, Animal ; Female ; Glucuronidase/metabolism ; Humans ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
Irinotecan-induced intestinal mucositis in mice: a histopathological study.
Autorzy :
Boeing T; Pharmaceutical Sciences Graduate Program, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil. .; School of Pharmaceutical Sciences of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. .
Gois MB; Federal University of Recôncavo of Bahia and Institute of Health Sciences, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
de Souza P; Pharmaceutical Sciences Graduate Program, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil.
Somensi LB; Pharmaceutical Sciences Graduate Program, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil.
Sant Ana DMG; Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
da Silva LM; Pharmaceutical Sciences Graduate Program, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, Santa Catarina, Brazil.
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Źródło :
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Mar; Vol. 87 (3), pp. 327-336. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Intestinal Mucosa/*drug effects
Irinotecan/*toxicity
Mucositis/*chemically induced
Topoisomerase I Inhibitors/*toxicity
Animals ; Colon/drug effects ; Colon/pathology ; Female ; Intestinal Mucosa/pathology ; Intestine, Small/drug effects ; Intestine, Small/pathology ; Irinotecan/administration & dosage ; Mice ; Mucositis/pathology ; Topoisomerase I Inhibitors/administration & dosage
Czasopismo naukowe
Tytuł :
LifePearl microspheres loaded with irinotecan in the treatment of Liver-dominant metastatic colorectal carcinoma: feasibility, safety and pharmacokinetic study.
Autorzy :
Maleux G; Department of Radiology, University Hospital Leuven, Leuven.
Prenen H; Department of Oncology, University Hospital Antwerp (UZ Antwerp), Antwerp, Belgium.
Helmberger T; Institut für Diagnostische und Interventionelle Radiologie, München, Germany.
Spriet I; University of Leuven, Pharmacotechnology and Biopharmacy Leuven, Belgium.
Isailovic TV; School of Medicine, University of Belgrade, Belgrade, Serbia.
Pereira P; Department of Radiology, Minimal-Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn, Heilbronn, Germany.
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Źródło :
Anti-cancer drugs [Anticancer Drugs] 2020 Nov; Vol. 31 (10), pp. 1084-1090.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Colorectal Neoplasms/*pathology
Drug Delivery Systems/*methods
Irinotecan/*administration & dosage
Irinotecan/*pharmacokinetics
Liver Neoplasms/*drug therapy
Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/blood ; Antineoplastic Agents/pharmacokinetics ; Colorectal Neoplasms/drug therapy ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Feasibility Studies ; Female ; Humans ; Irinotecan/adverse effects ; Irinotecan/blood ; Liver Neoplasms/secondary ; Male ; Microspheres ; Middle Aged
Czasopismo naukowe
Tytuł :
Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells.
Autorzy :
Matsunaga T; Education Center of Green Pharmaceutical Sciences, Gifu Pharmaceutical University, Gifu, 502-8585, Japan. Electronic address: .
Okumura N; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.
Saito H; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.
Morikawa Y; Forensic Science Laboratory, Gifu Prefectural Police Headquarters, Gifu, 500-8501, Japan.
Suenami K; Forensic Science Laboratory, Gifu Prefectural Police Headquarters, Gifu, 500-8501, Japan.
Hisamatsu A; Education Center of Green Pharmaceutical Sciences, Gifu Pharmaceutical University, Gifu, 502-8585, Japan.
Endo S; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.
Ikari A; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Dec 01; Vol. 332, pp. 109295. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Aldo-Keto Reductase Family 1 Member C3/*metabolism
Colonic Neoplasms/*metabolism
Drug Resistance, Neoplasm/*drug effects
Irinotecan/*pharmacology
ATP Binding Cassette Transporter, Subfamily B/metabolism ; Aldehydes/metabolism ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Irinotecan/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
An ultrasound responsive microbubble-liposome conjugate for targeted irinotecan-oxaliplatin treatment of pancreatic cancer.
Autorzy :
Gao J; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
Nesbitt H; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
Logan K; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
Burnett K; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
White B; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
Jack IG; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
Taylor MA; Department of HPB Surgery, Mater Hospital, Belfast, Northern Ireland BT14 6AB, UK.
Love M; Imaging Centre, The Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland BT12 6BA, UK.
Callan B; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
McHale AP; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.
Callan JF; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK. Electronic address: .
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Źródło :
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2020 Dec; Vol. 157, pp. 233-240. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
Ultrasonics*
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Irinotecan/*pharmacology
Lipids/*chemistry
Oxaliplatin/*pharmacology
Pancreatic Neoplasms/*drug therapy
Animals ; Antineoplastic Combined Chemotherapy Protocols/chemistry ; Cell Line, Tumor ; Drug Compounding ; Female ; Irinotecan/chemistry ; Liposomes ; Mice, Inbred BALB C ; Mice, SCID ; Microbubbles ; Oxaliplatin/chemistry ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Reduction-responsive sulfur dioxide polymer prodrug nanoparticles loaded with irinotecan for combination osteosarcoma therapy.
Autorzy :
Li Y; Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, 4 Chongshandong Road, Shenyang 110032, People's Republic of China.
Qu J
Zhang P
Zhang Z
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Źródło :
Nanotechnology [Nanotechnology] 2020 Nov 06; Vol. 31 (45), pp. 455101. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*drug therapy
Irinotecan/*administration & dosage
Osteosarcoma/*drug therapy
Prodrugs/*administration & dosage
Sulfur Dioxide/*administration & dosage
Topoisomerase I Inhibitors/*administration & dosage
Animals ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Female ; Humans ; Irinotecan/pharmacokinetics ; Irinotecan/pharmacology ; Mice, Inbred BALB C ; Micelles ; Nanoparticles/administration & dosage ; Osteosarcoma/pathology ; Oxidation-Reduction ; Polymers/administration & dosage ; Polymers/pharmacokinetics ; Polymers/pharmacology ; Prodrugs/pharmacokinetics ; Prodrugs/pharmacology ; Sulfur Dioxide/pharmacokinetics ; Sulfur Dioxide/pharmacology ; Topoisomerase I Inhibitors/pharmacokinetics ; Topoisomerase I Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Pharmacogenetic impact of UGT1A1 polymorphisms on pulmonary neuroendocrine tumours treated with metronomic irinotecan-based chemotherapy in Chinese populations.
Autorzy :
Ma X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy, Peking University Cancer Hospital & Institute, Haidian District, Beijing, China.
Han S; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Oncology Ⅱ, Peking University Cancer Hospital & Institute, Haidian District, Beijing, China.
Liu Y; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy, Peking University Cancer Hospital & Institute, Haidian District, Beijing, China.
Liu JT; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy, Peking University Cancer Hospital & Institute, Haidian District, Beijing, China.
Fang J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Oncology Ⅱ, Peking University Cancer Hospital & Institute, Haidian District, Beijing, China.
Zhang YH; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy, Peking University Cancer Hospital & Institute, Haidian District, Beijing, China.
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2020 Nov; Vol. 72 (11), pp. 1528-1535. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmacogenomic Variants*
Glucuronosyltransferase/*genetics
Irinotecan/*administration & dosage
Lung Neoplasms/*drug therapy
Neuroendocrine Tumors/*drug therapy
Topoisomerase I Inhibitors/*administration & dosage
Administration, Metronomic ; Aged ; Asian Continental Ancestry Group/genetics ; China/epidemiology ; Female ; Genotype ; Glucuronosyltransferase/metabolism ; Humans ; Irinotecan/adverse effects ; Lung Neoplasms/ethnology ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Neuroendocrine Tumors/ethnology ; Neuroendocrine Tumors/mortality ; Pharmacogenetics ; Pharmacogenomic Testing ; Phenotype ; Polymerase Chain Reaction ; Progression-Free Survival ; Topoisomerase I Inhibitors/adverse effects
Czasopismo naukowe
Tytuł :
Treatment of Lung Cancer by Peptide-Modified Liposomal Irinotecan Endowed with Tumor Penetration and NF-κB Inhibitory Activities.
Autorzy :
Hu Y; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Zhang Y; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Wang X; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Jiang K; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Wang H; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Yao S; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Liu Y; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Lin YZ; Celtek Bioscience, LLC, 2550 Meridian Boulevard, Suite 200, Franklin, Tennessee 37067, United States.
Wei G; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.; The Institutes of Integrative Medicine of Fudan University, Shanghai 200040, China.; Shanghai Engineering Research Center of ImmunoTherapeutics, Shanghai 201203, China.
Lu W; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.; The Institutes of Integrative Medicine of Fudan University, Shanghai 200040, China.
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Źródło :
Molecular pharmaceutics [Mol Pharm] 2020 Oct 05; Vol. 17 (10), pp. 3685-3695. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*drug therapy
Irinotecan/*administration & dosage
Lung Neoplasms/*drug therapy
NF-kappa B/*antagonists & inhibitors
Peptide Fragments/*chemistry
A549 Cells ; Animals ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/pathology ; Drug Compounding/methods ; Humans ; Irinotecan/pharmacokinetics ; Liposomes ; Lung Neoplasms/pathology ; Male ; Mice ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model.
Autorzy :
Gordon AC; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA. .; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. .
White SB; Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Yang Y; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.
Gates VL; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.
Procissi D; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.
Harris KR; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.
Zhang Z; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.
Lyu T; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.
Huang X; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.
Dreher MR; BTG International Inc, West Conshohocken, PA, USA.
Omary RA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Salem R; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.; Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Lewandowski RJ; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.; Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Larson AC; Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, Chicago, IL, 60611, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
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Źródło :
Cardiovascular and interventional radiology [Cardiovasc Intervent Radiol] 2020 Oct; Vol. 43 (10), pp. 1528-1537. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Chemoembolization, Therapeutic*/adverse effects
Microspheres*
Antineoplastic Agents/*administration & dosage
Irinotecan/*administration & dosage
Liver Neoplasms, Experimental/*therapy
Yttrium Radioisotopes/*administration & dosage
Animals ; Antineoplastic Agents/adverse effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Feasibility Studies ; Irinotecan/adverse effects ; Liver Neoplasms, Experimental/diagnostic imaging ; Magnetic Resonance Imaging ; Necrosis ; Rabbits ; Yttrium Radioisotopes/adverse effects
Czasopismo naukowe
Tytuł :
Determination of the UGT1A1 polymorphism as guidance for irinotecan dose escalation in metastatic colorectal cancer treated with first-line bevacizumab and FOLFIRI (PURE FIST).
Autorzy :
Tsai HL; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: .
Huang CW; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: .
Lin YW; Division of Colorectal Surgery, Department of Surgery, Tainan Municipal Hospital, Tainan, Taiwan. Electronic address: .
Wang JH; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address: .
Wu CC; Division of Colorectal Surgery, Department of Surgery, Keelung Branch, Tri-Service General Hospital, Keelung, Taiwan. Electronic address: .
Sung YC; Division of Medical Oncology, Department of Internal Medicine, Taipei Cathay General Hospital, Taipei, Taiwan. Electronic address: .
Chen TL; Division of Colorectal Surgery, Department of Surgery, Taichung China Medical University Hospital, Taichung, Taiwan. Electronic address: .
Wang HM; Division of Colorectal Surgery, Department of Surgery, Taichung China Medical University Hospital, Taichung, Taiwan. Electronic address: .
Tang HC; Division of Colorectal Surgery, Department of Surgery, Tainan Sin-Lan Hospital, Tainan, Taiwan. Electronic address: .
Chen JB; Division of Colorectal Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan. Electronic address: .
Ke TW; Division of Colorectal Surgery, Department of Surgery, Taichung China Medical University Hospital, Taichung, Taiwan. Electronic address: .
Tsai CS; Division of Medical Oncology, Department of Internal Medicine, Tainan Municipal Hospital, Tainan, Taiwan. Electronic address: .
Huang HY; Division of Colorectal Surgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan. Electronic address: .
Wang JY; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: .
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2020 Oct; Vol. 138, pp. 19-29. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Genetic*
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Bevacizumab/*administration & dosage
Camptothecin/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
Glucuronosyltransferase/*genetics
Irinotecan/*administration & dosage
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bevacizumab/adverse effects ; Camptothecin/administration & dosage ; Camptothecin/adverse effects ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Genotype ; Humans ; Irinotecan/adverse effects ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Male ; Middle Aged ; Neoplasm Metastasis ; Outcome Assessment, Health Care ; Proto-Oncogene Proteins p21(ras)/genetics
SCR Protocol :
IFL protocol
Czasopismo naukowe
Tytuł :
Impact of single-heterozygous UGT1A1 on the clinical outcomes of irinotecan monotherapy after fluoropyrimidine and platinum-based combination therapy for gastric cancer: a multicenter retrospective study.
Autorzy :
Nakano S; Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Kita14, Nishi5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.
Yuki S; Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Kita14, Nishi5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.
Kawamoto Y; Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Kita14, Nishi5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.
Nakatsumi H; Division of Cancer Center, Hokkaido University Hospital, Kita14, Nishi5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.
Ando T; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630, Sugitani, Toyama-shi, Toyama, 930-0194, Japan.
Kajiura S; Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630, Sugitani, Toyama-shi, Toyama, 930-0194, Japan.
Yoshikawa A; Department of Medical Oncology, Kushiro Rosai Hospital, 13-23 Nakazono-cho, Kushiro, Hokkaido, 085-8533, Japan.
Harada K; Department of Medical Oncology, Kushiro Rosai Hospital, 13-23 Nakazono-cho, Kushiro, Hokkaido, 085-8533, Japan.
Hatanaka K; Department of Gastroenterology, Hakodate Municipal Hospital, 1-10-1 Minatomachi, Hakodate, Hokkaido, 041-8680, Japan.
Tanimoto A; Department of Medical Oncology, Teine Keijinkai Hospital, 1-40, Maeda1-12, Teine-Ku, Sapporo, Hokkaido, 006-8555, Japan.
Ishiguro A; Department of Medical Oncology, Teine Keijinkai Hospital, 1-40, Maeda1-12, Teine-Ku, Sapporo, Hokkaido, 006-8555, Japan.
Honda T; Division of Clinical Oncology Center, Nagasaki University Hospital, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Dazai M; Department of Gastroenterology, Sapporo Medical Center NTT EC, Minami1, Nishi5, Chuo-Ku, Sapporo, Hokkaido, 060-0061, Japan.
Sasaki T; Department of Internal Medicine, Hokkaido Gastroenterology Hospital, 2-10, Honcho1-1, Higashi-Ku, Sapporo, Hokkaido, 065-0041, Japan.
Sakamoto N; Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Kita14, Nishi5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.
Komatsu Y; Division of Cancer Center, Hokkaido University Hospital, Kita14, Nishi5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan. .
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Źródło :
International journal of clinical oncology [Int J Clin Oncol] 2020 Oct; Vol. 25 (10), pp. 1800-1806. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Glucuronosyltransferase/*genetics
Irinotecan/*therapeutic use
Pyrimidines/*therapeutic use
Stomach Neoplasms/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Female ; Heterozygote ; Humans ; Irinotecan/adverse effects ; Male ; Middle Aged ; Platinum Compounds/administration & dosage ; Pyrimidines/administration & dosage ; Retrospective Studies ; Stomach Neoplasms/genetics ; Stomach Neoplasms/mortality ; Treatment Outcome ; Young Adult
Czasopismo naukowe

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