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Wyświetlanie 1-14 z 14
Tytuł :
Discovery of a novel and potent class of anti-HIV-1 maturation inhibitors with improved virology profile against gag polymorphisms.
Autorzy :
Tang J; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA. Electronic address: .
Jones SA; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
Jeffrey JL; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
Miranda SR; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
Galardi CM; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
Irlbeck DM; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
Brown KW; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
McDanal CB; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
Johns BA; GlaxoSmithKline Research & Development, Infectious Diseases Therapy Area Unit, Research Triangle Park, NC 27709, USA.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 15; Vol. 27 (12), pp. 2689-2694. Date of Electronic Publication: 2017 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Amides/*pharmacology
Anti-HIV Agents/*pharmacology
HIV-1/*drug effects
Polymorphism, Genetic/*drug effects
Triterpenes/*pharmacology
gag Gene Products, Human Immunodeficiency Virus/*antagonists & inhibitors
Amides/chemical synthesis ; Amides/chemistry ; Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Polymorphism, Genetic/genetics ; Structure-Activity Relationship ; Triterpenes/chemistry ; gag Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Synthesis and Biological Evaluation of Macrocyclized Betulin Derivatives as a Novel Class of Anti-HIV-1 Maturation Inhibitors.
Autorzy :
Tang J; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
Jones SA; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
Jeffery JL; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
Miranda SR; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
Galardi CM; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
Irlbeck DM; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
Brown KW; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
McDanal CB; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
Han N; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Gao D; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Wu Y; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Shen B; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Liu C; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Xi C; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Yang H; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Li R; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Yu Y; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Sun Y; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Jin Z; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Wang E; ShangPharma Discovery Chemistry Services, Zhangjiang High-tech Park, Pudong, Shanghai 201203, China.
Johns BA; GlaxoSmithKline Research & Development, Research Triangle Park, NC 27709, USA.
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Źródło :
The open medicinal chemistry journal [Open Med Chem J] 2014 Sep 03; Vol. 8, pp. 23-7. Date of Electronic Publication: 2014 Sep 03 (Print Publication: 2014).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank.
Autorzy :
Irlbeck DM
Vernon SD
McCleary KK
Bateman L
Klimas NG
Lapp CW
Peterson DL
Brown JR
Remlinger KS
Wilfret DA
Gerondelis P; Division of Infectious Diseases, GlaxoSmithKline, Research Triangle Park, NC, USA. .
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Źródło :
BMC research notes [BMC Res Notes] 2014 Aug 04; Vol. 7, pp. 461. Date of Electronic Publication: 2014 Aug 04.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Biological Specimen Banks*
Fatigue Syndrome, Chronic/*virology
Leukemia Virus, Murine/*isolation & purification
Xenotropic murine leukemia virus-related virus/*isolation & purification
Adult ; Animals ; Base Sequence ; Case-Control Studies ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Demography ; Female ; Humans ; Male ; Mice ; Middle Aged ; Phylogeny ; Polymerase Chain Reaction ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Interplay between single resistance-associated mutations in the HIV-1 protease and viral infectivity, protease activity, and inhibitor sensitivity.
Autorzy :
Henderson GJ; UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lee SK
Irlbeck DM
Harris J
Kline M
Pollom E
Parkin N
Swanstrom R
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2012 Feb; Vol. 56 (2), pp. 623-33. Date of Electronic Publication: 2011 Nov 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mutation*
Drug Resistance, Viral/*genetics
HIV Protease/*metabolism
HIV Protease Inhibitors/*pharmacology
HIV-1/*drug effects
HIV-1/*pathogenicity
Animals ; Cell Line ; Drug Resistance, Viral/drug effects ; Gene Products, env/genetics ; Gene Products, env/metabolism ; HIV Protease/drug effects ; HIV Protease/genetics ; HIV-1/enzymology ; HIV-1/genetics ; Humans ; Leukemia Virus, Murine/genetics ; Leukemia Virus, Murine/metabolism ; Mice ; Microbial Sensitivity Tests ; Virion/drug effects ; Virion/enzymology ; Virion/genetics ; Virion/pathogenicity ; Virus Replication/drug effects ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope.
Autorzy :
Kitrinos KM; GlaxoSmithKline Virology, Research Triangle Park, North Carolina 27709, USA.
Amrine-Madsen H
Irlbeck DM
Word JM
Demarest JF
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Corporate Authors :
CCR100136 Study Team
Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2009 Mar; Vol. 53 (3), pp. 1124-31. Date of Electronic Publication: 2008 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*therapeutic use
Benzoates/*therapeutic use
HIV Protease Inhibitors/*therapeutic use
Piperazines/*therapeutic use
Pyrimidinones/*therapeutic use
Ritonavir/*therapeutic use
Spiro Compounds/*therapeutic use
Clinical Trials as Topic/adverse effects ; Diketopiperazines ; Drug Interactions ; Drug Resistance, Viral/genetics ; Drug Therapy, Combination ; Evolution, Molecular ; Humans ; Inhibitory Concentration 50 ; Lopinavir ; Treatment Failure ; Tropism/genetics ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Virologic failure in first-line human immunodeficiency virus therapy with a CCR5 entry inhibitor, aplaviroc, plus a fixed-dose combination of lamivudine-zidovudine: nucleoside reverse transcriptase inhibitor resistance regardless of envelope tropism.
Autorzy :
Demarest JF; GlaxoSmithKline Virology, Research Triangle Park, North Carolina 27709, USA. />Amrine-Madsen H
Irlbeck DM
Kitrinos KM
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Corporate Authors :
CCR102881 Clinical Study Team
Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2009 Mar; Vol. 53 (3), pp. 1116-23. Date of Electronic Publication: 2008 Dec 15.
Typ publikacji :
Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Reverse Transcriptase Inhibitors*/administration & dosage
Reverse Transcriptase Inhibitors*/therapeutic use
Anti-HIV Agents/*therapeutic use
Benzoates/*therapeutic use
HIV Infections/*drug therapy
Lamivudine/*therapeutic use
Piperazines/*therapeutic use
Spiro Compounds/*therapeutic use
Zidovudine/*therapeutic use
Anti-HIV Agents/administration & dosage ; Diketopiperazines ; Drug Combinations ; Drug Resistance, Viral/genetics ; HIV Infections/genetics ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Lamivudine/administration & dosage ; Phylogeny ; Receptors, CCR5/genetics ; Receptors, CCR5/therapeutic use ; Treatment Failure ; Tropism/genetics ; Zidovudine/administration & dosage ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Sensitivity of phenotypic susceptibility analyses for nonthymidine nucleoside analogues conferred by K65R or M184V in mixtures with wild-type HIV-1.
Autorzy :
Underwood MR; GlaxoSmithKline, Inc., Research Triangle Park, North Carolina 27709-3398, USA. />Ross LL
Irlbeck DM
Gerondelis P
Rouse E
St Clair MH
Trinh L
Parkin N
Lanier E
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2009 Jan 01; Vol. 199 (1), pp. 84-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
HIV-1/*genetics
Adenine/analogs & derivatives ; Adenine/therapeutic use ; Didanosine/therapeutic use ; Dideoxynucleosides/therapeutic use ; Drug Therapy, Combination ; Genetic Predisposition to Disease ; Genotype ; Humans ; Lamivudine/therapeutic use ; Organophosphonates/therapeutic use ; Phenotype ; Plasmids ; Tenofovir ; Viral Load
Czasopismo naukowe
Tytuł :
Chemokine (C-C motif) receptor 5-using envelopes predominate in dual/mixed-tropic HIV from the plasma of drug-naive individuals.
Autorzy :
Irlbeck DM; GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. david.m.irlbeck@gsk.com
Amrine-Madsen H
Kitrinos KM
Labranche CC
Demarest JF
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Źródło :
AIDS (London, England) [AIDS] 2008 Jul 31; Vol. 22 (12), pp. 1425-31.
Typ publikacji :
Journal Article
MeSH Terms :
HIV Infections/*virology
HIV-1/*physiology
Receptors, CCR5/*metabolism
Benzoates/pharmacology ; CD4 Lymphocyte Count ; Cells, Cultured ; Diketopiperazines ; Drug Resistance, Viral ; Evolution, Molecular ; HIV Fusion Inhibitors/pharmacology ; HIV Infections/immunology ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; Phylogeny ; Piperazines/pharmacology ; RNA, Viral/blood ; Receptors, CXCR4/metabolism ; Spiro Compounds/pharmacology ; Tropism ; env Gene Products, Human Immunodeficiency Virus
Czasopismo naukowe
    Wyświetlanie 1-14 z 14

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