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Tytuł :
Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.
Autorzy :
Kawashima M; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hitomi Y; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Aiba Y; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Nishida N; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Kojima K; Division of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kawai Y; Division of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Nakamura H; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Tanaka A; Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Zeniya M; Department of Gastroenterology and Hepatology, Tokyo Jikei University School of Medicine, Tokyo, Japan.
Hashimoto E; Department of Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Ohira H; Department of Gastroenterology and Rheumatic Diseases, Fukushima Medical University of Medicine, Fukushima, Japan.
Yamamoto K; Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Abe M; Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Matsuyama, Japan.
Nakao K; Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagaski, Japan.
Yamagiwa S; Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Kaneko S; Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Honda M; Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Umemura T; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Ichida T; Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
Seike M; First Department of Internal Medicine, Faculty of Medicine, Oita University, Oita, Japan.
Sakisaka S; Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Harada M; The Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yokosuka O; Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ueno Y; Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Senju M; The Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kanda T; Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Shibata H; Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagaski, Japan.
Himoto T; Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, Japan.
Murata K; The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Miyake Y; Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Ebinuma H; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio Graduate School of Medicine, Tokyo, Japan.
Taniai M; Department of Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Joshita S; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Nikami T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Ota H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kouno H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kouno H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Nakamuta M; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Fukushima N; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kohjima M; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Komatsu T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Komeda T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Ohara Y; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Muro T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Yamashita T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Yoshizawa K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Nakamura Y; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Shimada M; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hirashima N; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Sugi K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Ario K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Takesaki E; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Naganuma A; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Mano H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Yamashita H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Matsushita K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Yamauchi K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Makita F; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Nishimura H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Furuta K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Takahashi N; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kikuchi M; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Masaki N; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Tanaka T; Organ Transplantation Service, The University of Tokyo, Tokyo, Japan.
Tamura S; Hepatobiliarypancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Mori A; Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yagi S; Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shirabe K; Department of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Komori A; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.; Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan.
Migita K; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.; Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan.
Ito M; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.; Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan.
Nagaoka S; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Abiru S; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Yatsuhashi H; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.; Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan.
Yasunami M; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Shimoda S; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Harada K; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Egawa H; Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Maehara Y; Department of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Uemoto S; Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kokudo N; Hepatobiliarypancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takikawa H; Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Ishibashi H; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.; Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan.
Chayama K; Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Mizokami M; The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Nagasaki M; Division of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Tokunaga K; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Nakamura M; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.; Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan.; Headquaters of gp210 Working Group in Intractable Liver Disease Research Project Team of the Ministry of Health and Welfare in Japan, Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2017 Feb 01; Vol. 26 (3), pp. 650-659.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Liver Cirrhosis, Biliary/*genetics
Protein Kinase C beta/*genetics
Asian Continental Ancestry Group ; Female ; Genotype ; Humans ; Japan ; Liver Cirrhosis, Biliary/pathology ; Male ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
[Clinical guidelines for bone disease in primary biliary cirrhosis].
Autorzy :
Ishibashi H; International University of Health and Welfare/Fukuoka Sanno Hospital, Japan.
Komori A; National Hospital Organization(NHO)Nagasaki Medical Center Clinical Research Center, Japan.
Pokaż więcej
Źródło :
Clinical calcium [Clin Calcium] 2015 Nov; Vol. 25 (11), pp. 1675-80.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Practice Guidelines as Topic*
Bone Diseases/*drug therapy
Liver Cirrhosis, Biliary/*complications
Bone Density ; Bone Diseases/etiology ; Calcium/therapeutic use ; Humans ; Vitamin D/therapeutic use ; Weight-Bearing
Czasopismo naukowe
Tytuł :
Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis.
Autorzy :
Aiba Y; Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Omura, Japan.
Harada K
Komori A
Ito M
Shimoda S
Nakamura H
Nagaoka S
Abiru S
Migita K
Ishibashi H
Nakanuma Y
Nishida N
Kawashima M
Tokunaga K
Yatsuhashi H
Nakamura M
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Źródło :
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2014 May; Vol. 34 (5), pp. 679-88. Date of Electronic Publication: 2013 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver Cirrhosis, Biliary/*blood
Receptors, Tumor Necrosis Factor, Member 6b/*blood
Tumor Necrosis Factor Ligand Superfamily Member 15/*blood
Adult ; Aged ; Antibodies, Antinuclear/blood ; Case-Control Studies ; Cholagogues and Choleretics/therapeutic use ; Female ; Humans ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis, Biliary/drug therapy ; Liver Cirrhosis, Biliary/pathology ; Male ; Middle Aged ; Ursodeoxycholic Acid/therapeutic use
Czasopismo naukowe
Tytuł :
Genetic polymorphisms of OCT-1 confer susceptibility to severe progression of primary biliary cirrhosis in Japanese patients.
Autorzy :
Ohishi Y; Department of Pharmacy, Clinical Research Institute, National Hospital Organization (NHO) Kyushu Medical Center, 1-8-1 Jigyouhama, Fukuoka, 810-8563, Japan.
Nakamuta M
Ishikawa N
Saitoh O
Nakamura H
Aiba Y
Komori A
Migita K
Yatsuhashi H
Fukushima N
Kohjima M
Yoshimoto T
Fukuizumi K
Ishibashi M
Nishino T
Shirabe K
Taketomi A
Maehara Y
Ishibashi H
Nakamura M
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Corporate Authors :
PBC Study Group of NHOSLJ
Źródło :
Journal of gastroenterology [J Gastroenterol] 2014 Feb; Vol. 49 (2), pp. 332-42. Date of Electronic Publication: 2013 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Genetic Predisposition to Disease/*genetics
Jaundice/*genetics
Liver Cirrhosis, Biliary/*genetics
Organic Cation Transporter 1/*genetics
Adult ; Aged ; Case-Control Studies ; Disease Progression ; Female ; Genotype ; Humans ; Japan ; Jaundice/etiology ; Liver Cirrhosis, Biliary/complications ; Liver Cirrhosis, Biliary/pathology ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis.
Autorzy :
Joshita S; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Umemura T; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Nakamura M; Clinical Research Center, NHO Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, 2-1001-1 Kubara, Omura 856-8562, Japan.
Katsuyama Y; Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Shibata S; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Kimura T; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Morita S; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Komatsu M; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Matsumoto A; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Yoshizawa K; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Ishibashi H; Clinical Research Center, NHO Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, 2-1001-1 Kubara, Omura 856-8562, Japan.
Tanaka E; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Ota M; Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
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Źródło :
Disease markers [Dis Markers] 2014; Vol. 2014, pp. 727393. Date of Electronic Publication: 2014 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Antinuclear/*blood
Liver Cirrhosis, Biliary/*genetics
STAT4 Transcription Factor/*genetics
Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Interleukin-12 Subunit p35/genetics ; Japan ; Linkage Disequilibrium ; Liver Cirrhosis, Biliary/blood ; Liver Cirrhosis, Biliary/immunology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Receptors, Interleukin-12/genetics
Czasopismo naukowe
Tytuł :
[Development of the clinical practice guideline of primary biliary cirrhosis (PBC)].
Autorzy :
Ishibashi H; International University of Health and Welfare/Fukuoka Sanno Hospital. />Komori A
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Źródło :
Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology [Nihon Shokakibyo Gakkai Zasshi] 2013 Jan; Vol. 110 (1), pp. 1-7.
Typ publikacji :
Journal Article
MeSH Terms :
Practice Guidelines as Topic*
Liver Cirrhosis, Biliary/*therapy
Humans
Czasopismo naukowe
Tytuł :
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
Autorzy :
Nakamura M; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki 856-8562, Japan. />Nishida N
Kawashima M
Aiba Y
Tanaka A
Yasunami M
Nakamura H
Komori A
Nakamuta M
Zeniya M
Hashimoto E
Ohira H
Yamamoto K
Onji M
Kaneko S
Honda M
Yamagiwa S
Nakao K
Ichida T
Takikawa H
Seike M
Umemura T
Ueno Y
Sakisaka S
Kikuchi K
Ebinuma H
Yamashiki N
Tamura S
Sugawara Y
Mori A
Yagi S
Shirabe K
Taketomi A
Arai K
Monoe K
Ichikawa T
Taniai M
Miyake Y
Kumagi T
Abe M
Yoshizawa K
Joshita S
Shimoda S
Honda K
Takahashi H
Hirano K
Takeyama Y
Harada K
Migita K
Ito M
Yatsuhashi H
Fukushima N
Ota H
Komatsu T
Saoshiro T
Ishida J
Kouno H
Kouno H
Yagura M
Kobayashi M
Muro T
Masaki N
Hirata K
Watanabe Y
Nakamura Y
Shimada M
Hirashima N
Komeda T
Sugi K
Koga M
Ario K
Takesaki E
Maehara Y
Uemoto S
Kokudo N
Tsubouchi H
Mizokami M
Nakanuma Y
Tokunaga K
Ishibashi H
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Źródło :
American journal of human genetics [Am J Hum Genet] 2012 Oct 05; Vol. 91 (4), pp. 721-8. Date of Electronic Publication: 2012 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver Cirrhosis, Biliary/*genetics
Trans-Activators/*genetics
Tumor Necrosis Factor Ligand Superfamily Member 15/*genetics
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; B-Lymphocytes ; Case-Control Studies ; Cell Differentiation/genetics ; European Continental Ancestry Group/genetics ; Female ; Genetic Loci/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study/methods ; HLA Antigens/genetics ; Humans ; Male ; Middle Aged ; NF-kappa B p50 Subunit/genetics ; Polymorphism, Genetic ; STAT4 Transcription Factor/genetics ; Tumor Necrosis Factor-alpha/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.
Autorzy :
Shimoda S; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Tsuneyama K
Kikuchi K
Harada K
Nakanuma Y
Nakamura M
Ishibashi H
Hisamoto S
Niiro H
Leung PS
Ansari AA
Gershwin ME
Akashi K
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Źródło :
Clinical and experimental immunology [Clin Exp Immunol] 2012 Jun; Vol. 168 (3), pp. 279-84.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Tolerance*
Dihydrolipoyllysine-Residue Acetyltransferase/*immunology
Killer Cells, Natural/*metabolism
Liver Cirrhosis, Biliary/*immunology
Mitochondria/*immunology
Mitochondrial Proteins/*immunology
Natural Killer T-Cells/*metabolism
Animals ; Autoantibodies/blood ; Autoantigens/immunology ; Biomimetic Materials/chemistry ; Cattle ; Cells, Cultured ; Cytokines/blood ; Dihydrolipoyllysine-Residue Acetyltransferase/chemistry ; Dihydrolipoyllysine-Residue Acetyltransferase/metabolism ; Disease Models, Animal ; Humans ; Immunization ; Immunodominant Epitopes/chemistry ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Lymphocyte Depletion ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Mitochondrial Proteins/chemistry ; Mitochondrial Proteins/metabolism ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/pathology ; Peptide Fragments/administration & dosage ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Serum Albumin, Bovine/administration & dosage ; Serum Albumin, Bovine/chemistry ; Thioctic Acid/administration & dosage ; Thioctic Acid/chemistry ; Thioctic Acid/metabolism
Czasopismo naukowe
Tytuł :
[Pathogenesis of biliary tract injury in primary biliary cirrhosis].
Autorzy :
Ishibashi H; International University of Health and Welfare.
Shimoda S
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Źródło :
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology [Nihon Rinsho Meneki Gakkai Kaishi] 2012; Vol. 35 (6), pp. 455-62.
Typ publikacji :
English Abstract; Journal Article; Review
MeSH Terms :
Autoimmunity*
Bile Ducts, Intrahepatic/*immunology
Bile Ducts, Intrahepatic/*pathology
Liver Cirrhosis, Biliary/*immunology
Animals ; Bile Ducts, Intrahepatic/cytology ; Cell Movement ; Chemokine CX3CL1/metabolism ; Epithelial Cells/immunology ; Female ; Humans ; Immunity, Innate/immunology ; Interferon-alpha/immunology ; Killer Cells, Natural/immunology ; Ligands ; Liver Cirrhosis, Biliary/genetics ; Liver Cirrhosis, Biliary/pathology ; Male ; Mice ; Toll-Like Receptor 3/immunology ; Toll-Like Receptor 4/immunology ; Xenobiotics/adverse effects
Czasopismo naukowe
Tytuł :
[Proposal of novel staging and grading system of primary biliary cirrhosis].
Autorzy :
Nakanuma Y; Department of Human Pathology, Kanazawa University Graduate School of Medicine.
Ishibashi H
Takikawa H
Tsubouchi H
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Źródło :
Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology [Nihon Shokakibyo Gakkai Zasshi] 2011 Nov; Vol. 108 (11), pp. 1817-22.
Typ publikacji :
Journal Article
MeSH Terms :
Liver Cirrhosis, Biliary/*diagnosis
Disease Progression ; Humans ; Liver Cirrhosis, Biliary/classification ; Liver Cirrhosis, Biliary/pathology
Czasopismo naukowe
Tytuł :
Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients.
Autorzy :
Aiba Y; Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki 856-8562, Japan.
Nakamura M
Joshita S
Inamine T
Komori A
Yoshizawa K
Umemura T
Horie H
Migita K
Yatsuhashi H
Nakamuta M
Fukushima N
Saoshiro T
Hayashi S
Kouno H
Ota H
Muro T
Watanabe Y
Nakamura Y
Komeda T
Shimada M
Masaki N
Komatsu T
Yagura M
Sugi K
Koga M
Tsukamoto K
Tanaka E
Ishibashi H
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Corporate Authors :
PBC Study Group in NHOSLJ
Źródło :
Journal of gastroenterology [J Gastroenterol] 2011 Oct; Vol. 46 (10), pp. 1203-12. Date of Electronic Publication: 2011 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anion Transport Proteins/*genetics
Antiporters/*genetics
Autoantibodies/*immunology
CTLA-4 Antigen/*genetics
Liver Cirrhosis, Biliary/*genetics
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Centromere/immunology ; Chloride-Bicarbonate Antiporters ; Disease Progression ; Female ; Genetic Predisposition to Disease ; Humans ; Japan ; Liver Cirrhosis, Biliary/immunology ; Liver Cirrhosis, Biliary/physiopathology ; Male ; Middle Aged ; Nuclear Pore Complex Proteins/immunology ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Risk Factors ; SLC4A Proteins
Czasopismo naukowe
Tytuł :
A polymorphism in the integrin αV subunit gene affects the progression of primary biliary cirrhosis in Japanese patients.
Autorzy :
Inamine T; Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nakamura M
Kawauchi A
Shirakawa Y
Hashiguchi H
Aiba Y
Taketomi A
Shirabe K
Nakamuta M
Hayashi S
Saoshiro T
Komori A
Yatsuhashi H
Kondo S
Omagari K
Maehara Y
Ishibashi H
Tsukamoto K
Pokaż więcej
Corporate Authors :
PBC Study Group in NHOSLJ
Źródło :
Journal of gastroenterology [J Gastroenterol] 2011 May; Vol. 46 (5), pp. 676-86. Date of Electronic Publication: 2010 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
End Stage Liver Disease/*etiology
Integrin alphaV/*genetics
Liver Cirrhosis, Biliary/*genetics
Adult ; Aged ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Disease Progression ; End Stage Liver Disease/genetics ; End Stage Liver Disease/therapy ; Female ; Genetic Predisposition to Disease ; Humans ; Japan ; Liver Transplantation ; Male ; Middle Aged ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Primary biliary cirrhosis and autoimmune hepatitis: apotopes and epitopes.
Autorzy :
Lleo A; Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA.
Shimoda S
Ishibashi H
Gershwin ME
Pokaż więcej
Źródło :
Journal of gastroenterology [J Gastroenterol] 2011 Jan; Vol. 46 Suppl 1, pp. 29-38. Date of Electronic Publication: 2010 Aug 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Epitopes/*immunology
Hepatitis, Autoimmune/*immunology
Liver Cirrhosis, Biliary/*immunology
Animals ; Apoptosis/immunology ; Autoantigens/immunology ; Cytochrome P-450 CYP2D6/immunology ; Dihydrolipoyllysine-Residue Acetyltransferase/immunology ; Epithelial Cells/metabolism ; Hepatitis, Autoimmune/classification ; Humans
Czasopismo naukowe
Tytuł :
Risk factors and prediction of long-term outcome in primary biliary cirrhosis.
Autorzy :
Ishibashi H; Clinical Research Center, National Hospital Organization Nagaski Medical Center, Japan. />Komori A
Shimoda S
Ambrosini YM
Gershwin ME
Nakamura M
Pokaż więcej
Źródło :
Internal medicine (Tokyo, Japan) [Intern Med] 2011; Vol. 50 (1), pp. 1-10. Date of Electronic Publication: 2011 Jan 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Liver Cirrhosis, Biliary/*etiology
Autoantibodies/blood ; Disease Progression ; Genetic Predisposition to Disease ; HLA-DR Antigens/genetics ; HLA-DRB1 Chains ; Humans ; Liver Cirrhosis, Biliary/complications ; Liver Cirrhosis, Biliary/physiopathology ; Liver Cirrhosis, Biliary/therapy ; Liver Failure/etiology ; Prognosis ; Risk Factors ; Ursodeoxycholic Acid/therapeutic use
Czasopismo naukowe
Tytuł :
Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
Autorzy :
Joshita S; Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Umemura T
Yoshizawa K
Katsuyama Y
Tanaka E
Nakamura M
Ishibashi H
Ota M
Pokaż więcej
Corporate Authors :
Shinshu PBC Study Group
Źródło :
Journal of hepatology [J Hepatol] 2010 Sep; Vol. 53 (3), pp. 537-41. Date of Electronic Publication: 2010 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Antigens, CD/*genetics
Liver Cirrhosis, Biliary/*genetics
Liver Cirrhosis, Biliary/*immunology
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/genetics ; Autoantibodies/blood ; CTLA-4 Antigen ; Case-Control Studies ; Cohort Studies ; Female ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Japan ; Male ; Middle Aged ; Mitochondria/immunology ; Risk Factors
Czasopismo naukowe
Tytuł :
Serum BAFF and APRIL levels in patients with PBC.
Autorzy :
Migita K; Clinical Research Center, Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8562, Japan. />Ilyassova B
Kovzel EF
Nersesov A
Abiru S
Maeda Y
Komori A
Ito M
Yano K
Yatsuhashi H
Shimoda S
Ishibashi H
Nakamura M
Pokaż więcej
Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2010 Feb; Vol. 134 (2), pp. 217-25. Date of Electronic Publication: 2009 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
B-Cell Activating Factor/*blood
Liver Cirrhosis, Biliary/*blood
Tumor Necrosis Factor Ligand Superfamily Member 13/*blood
Adult ; B-Cell Activation Factor Receptor/biosynthesis ; Cell Separation ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Humans ; Leukocytes, Mononuclear/immunology ; Liver Cirrhosis, Biliary/pathology ; Liver Cirrhosis, Biliary/physiopathology ; Liver Function Tests ; Lymphocytes/metabolism ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis.
Autorzy :
Shimoda S; Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. />Miyakawa H
Nakamura M
Ishibashi H
Kikuchi K
Kita H
Niiro H
Arinobu Y
Ono N
Mackay IR
Gershwin ME
Akashi K
Pokaż więcej
Źródło :
Journal of autoimmunity [J Autoimmun] 2008 Sep; Vol. 31 (2), pp. 110-5. Date of Electronic Publication: 2008 Jul 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptides*/genetics
Autoantibodies/*blood
Autoantigens/*immunology
CD4-Positive T-Lymphocytes/*immunology
Dihydrolipoyllysine-Residue Acetyltransferase/*immunology
Liver Cirrhosis, Biliary/*immunology
Mitochondrial Proteins/*immunology
Amino Acid Sequence ; Animals ; Autoantigens/genetics ; B-Lymphocytes/immunology ; Cells, Cultured ; Dihydrolipoyllysine-Residue Acetyltransferase/genetics ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Mice ; Mitochondrial Proteins/genetics ; Molecular Sequence Data ; T-Lymphocyte Subsets/immunology
Czasopismo naukowe
Tytuł :
Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis.
Autorzy :
Ohishi Y; Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nakamura M
Iio N
Higa S
Inayoshi M
Aiba Y
Komori A
Omagari K
Ishibashi H
Tsukamoto K
Pokaż więcej
Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2008 Sep; Vol. 48 (3), pp. 853-62.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B/*genetics
Liver Cirrhosis, Biliary/*diagnosis
Liver Cirrhosis, Biliary/*genetics
Polymorphism, Single Nucleotide/*genetics
Adult ; Aged ; Asian Continental Ancestry Group/genetics ; Biomarkers ; Case-Control Studies ; Disease Progression ; Female ; Genetic Predisposition to Disease/genetics ; Haplotypes/genetics ; Humans ; Japan ; Liver Cirrhosis, Biliary/ethnology ; Male ; Middle Aged ; Prognosis ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells.
Autorzy :
Shimoda S; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. />Harada K
Niiro H
Yoshizumi T
Soejima Y
Taketomi A
Maehara Y
Tsuneyama K
Nakamura M
Komori A
Migita K
Nakanuma Y
Ishibashi H
Selmi C
Gershwin ME
Pokaż więcej
Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2008 Mar; Vol. 47 (3), pp. 958-65.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Chemotaxis*
Autoimmune Diseases/*immunology
Bile Ducts, Intrahepatic/*immunology
Leukocytes, Mononuclear/*immunology
Liver Cirrhosis, Biliary/*immunology
Autoimmune Diseases/pathology ; Bile Ducts, Intrahepatic/pathology ; CD40 Antigens/analysis ; Cells, Cultured ; Chemokines/metabolism ; Epithelial Cells/pathology ; Female ; HLA-DR Antigens/analysis ; Humans ; Liver/immunology ; Liver/pathology ; Liver Cirrhosis, Biliary/pathology ; Male ; Toll-Like Receptors/agonists ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis.
Autorzy :
Kawano A; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Shimoda S
Kamihira T
Ishikawa F
Niiro H
Soejima Y
Taketomi A
Maehara Y
Nakamura M
Komori A
Migita K
Ishibashi H
Azuma M
Gershwin ME
Harada M
Pokaż więcej
Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2007 Sep 01; Vol. 179 (5), pp. 3315-24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Tolerance*
Autoantigens/*immunology
Clonal Anergy/*immunology
Liver Cirrhosis, Biliary/*immunology
T-Lymphocytes/*immunology
Acyltransferases/chemistry ; Acyltransferases/immunology ; Acyltransferases/pharmacology ; Animals ; Antigen-Presenting Cells/immunology ; Autoantigens/chemistry ; Autoantigens/pharmacology ; B7-1 Antigen/immunology ; B7-2 Antigen/immunology ; Cell Proliferation ; Coculture Techniques ; Cytokines/metabolism ; Dihydrolipoyllysine-Residue Acetyltransferase/chemistry ; Dihydrolipoyllysine-Residue Acetyltransferase/immunology ; Dihydrolipoyllysine-Residue Acetyltransferase/pharmacology ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/immunology ; Escherichia coli Proteins/pharmacology ; Fibroblasts/drug effects ; HLA-DR Antigens/immunology ; HLA-DRB4 Chains ; Humans ; Lymphocyte Activation ; Mice ; Peptides/chemistry ; Peptides/immunology ; T-Lymphocytes/drug effects
Czasopismo naukowe

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