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Tytuł :
ELF3 Is a Target That Promotes Therapeutic Efficiency in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer Cells via Inhibiting PKCί.
Autorzy :
Lee JS; Division of Cancer Biology, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea.
Choi YE; Division of Cancer Biology, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea.
Kim S; Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea.
Han JY; Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea.
Goh SH; Division of Cancer Biology, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 13; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Drug Delivery Systems*
Drug Resistance, Neoplasm*
Isoenzymes*/antagonists & inhibitors
Isoenzymes*/genetics
Isoenzymes*/metabolism
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Protein Kinase C*/antagonists & inhibitors
Protein Kinase C*/genetics
Protein Kinase C*/metabolism
Proto-Oncogene Proteins c-ets*/genetics
Proto-Oncogene Proteins c-ets*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Protein Kinase Inhibitors/*pharmacology
A549 Cells ; Amino Acid Substitution ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Gene Expression Profiling ; Gene Knockdown Techniques ; Humans ; Mutation, Missense ; Proto-Oncogene Proteins p21(ras)
Czasopismo naukowe
Tytuł :
Carbonic anhydrase activation profile of indole-based derivatives.
Autorzy :
Barresi E; Department of Pharmacy, University of Pisa, Pisa, Italy.
Ravichandran R; DiSTABiF, University of Campania Luigi Vanvitelli, Caserta, Italy.
Germelli L; Department of Pharmacy, University of Pisa, Pisa, Italy.
Angeli A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.
Baglini E; Department of Pharmacy, University of Pisa, Pisa, Italy.
Salerno S; Department of Pharmacy, University of Pisa, Pisa, Italy.
Marini AM; Department of Pharmacy, University of Pisa, Pisa, Italy.
Costa B; Department of Pharmacy, University of Pisa, Pisa, Italy.
Da Pozzo E; Department of Pharmacy, University of Pisa, Pisa, Italy.
Martini C; Department of Pharmacy, University of Pisa, Pisa, Italy.
Da Settimo F; Department of Pharmacy, University of Pisa, Pisa, Italy.
Supuran C; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.
Cosconati S; DiSTABiF, University of Campania Luigi Vanvitelli, Caserta, Italy.
Taliani S; Department of Pharmacy, University of Pisa, Pisa, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1783-1797.
Typ publikacji :
Journal Article
MeSH Terms :
Carbonic Anhydrases/*drug effects
Enzyme Activators/*pharmacology
Indoles/*pharmacology
Isoenzymes/*drug effects
Brain-Derived Neurotrophic Factor/metabolism ; Carbon-13 Magnetic Resonance Spectroscopy ; Carbonic Anhydrases/metabolism ; Cell Survival/drug effects ; Enzyme Activation ; Enzyme Activators/chemistry ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Indoles/chemistry ; Isoenzymes/metabolism ; Microglia/cytology ; Microglia/drug effects ; Models, Molecular ; Proton Magnetic Resonance Spectroscopy ; Substrate Specificity
Czasopismo naukowe
Tytuł :
An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human.
Autorzy :
Toyokawa Y; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Koonthongkaew J; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Takagi H; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 Nov; Vol. 105 (21-22), pp. 8059-8072. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Isoenzymes*/genetics
Saccharomyces cerevisiae*/genetics
Amino Acids, Branched-Chain ; Cytosol ; Humans ; Transaminases/genetics
Czasopismo naukowe
Tytuł :
Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening.
Autorzy :
Baburuna Y; Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow, Russia.
Sotnikova L; Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow, Russia.
Krestinina O; Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Calcium Signaling/*drug effects
Calpain/*metabolism
Isoenzymes/*metabolism
Mitochondria/*metabolism
Mitochondrial Membranes/*metabolism
Mitochondrial Permeability Transition Pore/*metabolism
Muscle Proteins/*metabolism
Animals ; Apoptosis/drug effects ; Calcium/metabolism ; Calpain/antagonists & inhibitors ; Calpain/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Dipeptides/pharmacology ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/chemistry ; Leupeptins/pharmacology ; Male ; Molecular Weight ; Muscle Proteins/antagonists & inhibitors ; Muscle Proteins/chemistry ; Phosphorylation ; Protein Transport ; Rats
Czasopismo naukowe
Tytuł :
Starch branching enzymes as putative determinants of postharvest quality in horticultural crops.
Autorzy :
Yu J; Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA.; Graduate Group of Horticulture & Agronomy, University of California, Davis, CA, 95616, USA.; Present Address: Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, PR China.
Wang K; Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA.
Beckles DM; Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA. .
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Źródło :
BMC plant biology [BMC Plant Biol] 2021 Oct 21; Vol. 21 (1), pp. 479. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Isoenzymes*
1,4-alpha-Glucan Branching Enzyme/*genetics
Crops, Agricultural/*enzymology
Starch/*metabolism
1,4-alpha-Glucan Branching Enzyme/metabolism ; Amino Acid Motifs ; Amylopectin/metabolism ; Amylose/metabolism ; Crops, Agricultural/genetics ; Crops, Agricultural/standards ; Edible Grain ; Food Storage ; Fruit ; Horticulture ; Phylogeny ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Tubers ; Sugars/metabolism ; Vegetables
Czasopismo naukowe
Tytuł :
Membrane partitioning and lipid selectivity of the N-terminal amphipathic H0 helices of endophilin isoforms.
Autorzy :
Robustelli J; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, United States.
Baumgart T; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2021 Oct 01; Vol. 1863 (10), pp. 183660. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acyltransferases/*metabolism
Isoenzymes/*metabolism
Acyltransferases/chemistry ; Amino Acid Sequence ; Cell Membrane/metabolism ; Circular Dichroism ; Hydrophobic and Hydrophilic Interactions ; Isoenzymes/chemistry ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach.
Autorzy :
Zhang YJ; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China.; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, China.; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China.
Zhou WL; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China.; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, China.; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China.; Anhui Institutes for Food and Drug Control, Hefei, China.
Yu F; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China.; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, China.; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China.; Anhui Institutes for Food and Drug Control, Hefei, China.
Wang Q; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China.; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, China.; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China.
Peng C; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China.; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, China.; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China.
Kan JY; Anhui Institutes for Food and Drug Control, Hefei, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Sep; Vol. 51 (9), pp. 1010-1018. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Isoenzymes*
Tandem Mass Spectrometry*
Animals ; Chromatography, Liquid ; Cytochrome P-450 Enzyme System ; Liver ; Microsomes, Liver ; Rats
Czasopismo naukowe
Tytuł :
circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma.
Autorzy :
Chen W; Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
Li Y; Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
Zhong J; Institute of Clinical Medicine, First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Wen G; Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jun; Vol. 23 (6). Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Carcinoma, Hepatocellular/*drug therapy
Forkhead Transcription Factors/*metabolism
Glycolysis/*drug effects
Isoenzymes/*metabolism
Liver Neoplasms/*drug therapy
MicroRNAs/*pharmacology
Protein Kinase C/*metabolism
Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation, Neoplastic ; Glucose Transporter Type 1/metabolism ; Hexokinase/metabolism ; Humans ; Isoenzymes/drug effects ; Isoenzymes/genetics ; L-Lactate Dehydrogenase ; Liver Neoplasms/genetics ; MicroRNAs/metabolism ; Protein Kinase C/drug effects ; Protein Kinase C/genetics ; RNA, Circular ; Up-Regulation
Czasopismo naukowe
Tytuł :
NAT1 is a critical prognostic biomarker and inhibits proliferation of colorectal cancer through modulation of PI3K/Akt/mTOR.
Autorzy :
Cai J; Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, PR China.
Sun H; Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, PR China.
Chen L; Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, PR China.
Xie M; Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, PR China.
Zhuang J; Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, PR China.
Gao L; Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, PR China.
Wei XX; Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, 350001, PR China.
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Źródło :
Future oncology (London, England) [Future Oncol] 2021 Jul; Vol. 17 (19), pp. 2489-2498. Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
Arylamine N-Acetyltransferase/*metabolism
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*mortality
Isoenzymes/*metabolism
Arylamine N-Acetyltransferase/analysis ; Biomarkers, Tumor/analysis ; Cell Line, Tumor ; Cell Proliferation/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Datasets as Topic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Isoenzymes/analysis ; Kaplan-Meier Estimate ; Male ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/genetics ; Prognosis ; RNA-Seq ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?
Autorzy :
Spiegel JL; Department for Otorhinolaryngology, LMU Klinikum, Marchioninistr, Ludwig-Maximilians-Universität München, 81377, Munich, Germany. .
Jakob M; Department for Otorhinolaryngology, LMU Klinikum, Marchioninistr, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Kruizenga M; Department of Otorhinolaryngology, Georg August University, University Hospital Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Freytag S; Molecular Medicine, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.
Bertlich M; Department for Otorhinolaryngology, LMU Klinikum, Marchioninistr, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Canis M; Department for Otorhinolaryngology, LMU Klinikum, Marchioninistr, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Ihler F; Department for Otorhinolaryngology, LMU Klinikum, Marchioninistr, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.; German Centre for Vertigo and Balance 508 Disorders, LMU Klinikum, Marchioninistr. 15, Ludwig-Maximilians-Universität , 81377, Munich, Germany.
Haubner F; Department for Otorhinolaryngology, LMU Klinikum, Marchioninistr, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Kitz J; Institute of Pathology, University Hospital Göttingen, Georg August University, Robert-Koch-Str. 40,, 37075, Göttingen, Germany.
Weiss BG; Department for Otorhinolaryngology, LMU Klinikum, Marchioninistr, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
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Źródło :
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2021 Jul; Vol. 278 (7), pp. 2517-2528. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma*
Isoenzymes*
Biomarkers, Tumor ; Humans ; Hyaluronan Receptors ; Neoplastic Stem Cells ; Prognosis ; Reproducibility of Results ; Retinal Dehydrogenase ; Salivary Glands
Czasopismo naukowe
Tytuł :
NADP -dependent isocitrate dehydrogenase isozymes from a psychrotrophic bacterium, Psychrobacter sp. strain 13A.
Autorzy :
Komura T; Biosystems Science Course, Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
Takada Y; Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo, Japan.
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Źródło :
Journal of basic microbiology [J Basic Microbiol] 2021 Jul; Vol. 61 (7), pp. 612-626. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Isocitrate Dehydrogenase/*genetics
Isocitrate Dehydrogenase/*metabolism
Isoenzymes/*metabolism
NADP/*metabolism
Psychrobacter/*enzymology
Psychrobacter/*genetics
Amino Acid Sequence ; Cloning, Molecular ; Cold Temperature ; Genes, Bacterial ; Isoenzymes/genetics ; Psychrobacter/metabolism ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Developments of small molecules as inhibitors for carbonic anhydrase isoforms.
Autorzy :
Buabeng ER; Department of Chemistry, 100 Piedmont Avenue SE, Georgia State University, Atlanta, GA 30303, USA; Center for Diagnostics and Therapeutics, 100 Piedmont Avenue SE, Georgia State University, Atlanta, GA 30303, USA.
Henary M; Department of Chemistry, 100 Piedmont Avenue SE, Georgia State University, Atlanta, GA 30303, USA; Center for Diagnostics and Therapeutics, 100 Piedmont Avenue SE, Georgia State University, Atlanta, GA 30303, USA. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jun 01; Vol. 39, pp. 116140. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Development*
Carbonic Anhydrase Inhibitors/*chemical synthesis
Carbonic Anhydrase Inhibitors/*pharmacology
Isoenzymes/*antagonists & inhibitors
Small Molecule Libraries/*chemical synthesis
Small Molecule Libraries/*pharmacology
Carbonic Anhydrase Inhibitors/chemistry ; Carbonic Anhydrases/metabolism ; Catalysis ; Humans ; Isoenzymes/metabolism ; Kinetics ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
6,6'-Dihydroxythiobinupharidine (DTBN) Purified from Nuphar lutea Leaves Is an Inhibitor of Protein Kinase C Catalytic Activity.
Autorzy :
Waidha K; Defence Institute of High Altitude Research (DIHAR), Defence Research and Development Organisation (DRDO) Leh, Ladakh UT-194101, India.
Anto NP; The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8400501, Israel.
Jayaram DR; The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8400501, Israel.
Golan-Goldhirsh A; The Jacob Blaustein Institutes for Desert Research (BIDR), Sede Boqer Campus, French Associates Institute for Agriculture and Biotechnology of Drylands, Ben-Gurion University of the Negev, Beer Sheva 8499000, Israel.
Rajendran S; Chemistry Division, Vellore Institute of Technology Chennai Campus, School of Advanced Sciences, Chennai 600127, India.
Livneh E; The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8400501, Israel.
Gopas J; The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8400501, Israel.; Department of Oncology, Soroka University Medical Center, Beer Sheva 8400501, Israel.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 08; Vol. 26 (9). Date of Electronic Publication: 2021 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Isoenzymes/*antagonists & inhibitors
Nuphar/*chemistry
Plant Extracts/*pharmacology
Plant Leaves/*chemistry
Protein Kinase C/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Alkaloids/chemistry ; Alkaloids/isolation & purification ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Isoenzymes/chemistry ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Protein Binding ; Protein Kinase C/chemistry ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/isolation & purification ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Long-term safety and efficacy of agalsidase beta in Japanese patients with Fabry disease: aggregate data from two post-authorization safety studies.
Autorzy :
Tsurumi M; Rare Disease Medical, Sanofi Genzyme Medical, Sanofi K.K., Tokyo, Japan.
Suzuki S; Rare Disease Medical, Sanofi Genzyme Medical, Sanofi K.K., Tokyo, Japan.
Hokugo J; Post-Authorization Regulatory Studies, Medical Affairs, Sanofi K.K., Tokyo, Japan.
Ueda K; Rare Disease Medical, Sanofi Genzyme Medical, Sanofi K.K., Tokyo, Japan.
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Źródło :
Expert opinion on drug safety [Expert Opin Drug Saf] 2021 May; Vol. 20 (5), pp. 589-601. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Replacement Therapy/*methods
Fabry Disease/*drug therapy
Isoenzymes/*administration & dosage
Trihexosylceramides/*blood
alpha-Galactosidase/*administration & dosage
Adolescent ; Adult ; Aged ; Enzyme Replacement Therapy/adverse effects ; Female ; Humans ; Isoenzymes/adverse effects ; Japan ; Male ; Middle Aged ; Product Surveillance, Postmarketing ; Treatment Outcome ; Young Adult ; alpha-Galactosidase/adverse effects
Czasopismo naukowe
Tytuł :
Effects of seawater acclimation on two Na -ATPase α-subunit isoforms in the gills of the marble goby, Oxyeleotris marmorata.
Autorzy :
Pang CZ; Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Republic of Singapore.
Ip YK; Department of Biological Sciences, National University of Singapore, Kent Ridge, Singapore 117543, Republic of Singapore.
Chew SF; Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Republic of Singapore. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology [Comp Biochem Physiol A Mol Integr Physiol] 2021 Mar; Vol. 253, pp. 110853. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Seawater*
Acclimatization/*physiology
Gills/*enzymology
Isoenzymes/*metabolism
Perciformes/*metabolism
Sodium-Potassium-Exchanging ATPase/*metabolism
Amino Acid Sequence ; Animals ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Osmoregulation ; Perciformes/classification ; Perciformes/genetics ; Phylogeny ; RNA, Messenger/metabolism ; Sequence Homology, Amino Acid ; Sodium-Potassium-Exchanging ATPase/chemistry ; Sodium-Potassium-Exchanging ATPase/genetics
Czasopismo naukowe
Tytuł :
Glutathione-S-transferase alpha-4 in Hippocampus abdominalis (big-belly seahorse): Molecular characterization, antioxidant properties, and its potent immune response.
Autorzy :
Nadarajapillai K; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea.
Liyanage DS; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea.
Sellaththurai S; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Republic of Korea.
Jeong T; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Republic of Korea.
Lee S; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Republic of Korea. Electronic address: .
Lee J; Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Republic of Korea. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2021 Feb; Vol. 240, pp. 108917. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Antioxidants/*metabolism
Fish Proteins/*genetics
Glutathione Transferase/*genetics
Immunity, Innate/*genetics
Isoenzymes/*genetics
Smegmamorpha/*genetics
Amino Acid Sequence ; Animals ; Edwardsiella tarda/immunology ; Edwardsiella tarda/physiology ; Fish Diseases/immunology ; Fish Diseases/microbiology ; Fish Proteins/classification ; Fish Proteins/metabolism ; Gene Expression Profiling/methods ; Glutathione Transferase/classification ; Glutathione Transferase/metabolism ; Hydrogen-Ion Concentration ; Isoenzymes/classification ; Isoenzymes/metabolism ; Liver/immunology ; Liver/metabolism ; Liver/microbiology ; Phylogeny ; Sequence Homology, Amino Acid ; Smegmamorpha/metabolism ; Streptococcus iniae/immunology ; Streptococcus iniae/physiology ; Temperature
Czasopismo naukowe
Tytuł :
Transcription factor Sp1 is upregulated by PKCι to drive the expression of YAP1 during pancreatic carcinogenesis.
Autorzy :
Yang J; Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, PR China.
Wang J; Department of Biochemistry, West China School of Basic Medical Sciences & Forensic Medicine, Sichan University, Chengdu, Sichuan, PR China.
Zhang H; Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, PR China.
Li C; Department of Biochemistry, West China School of Basic Medical Sciences & Forensic Medicine, Sichan University, Chengdu, Sichuan, PR China.
Chen C; The Center of Drug Discovery, Northeastern University, Boston, MA, USA.
Zhu T; Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, PR China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2021 Apr 17; Vol. 42 (3), pp. 344-356.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Isoenzymes/*metabolism
Pancreatic Neoplasms/*genetics
Protein Kinase C/*metabolism
Sp1 Transcription Factor/*genetics
Transcription Factors/*genetics
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Apoptosis/immunology ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Carcinogenesis/immunology ; Cell Line, Tumor ; Computational Biology ; Datasets as Topic ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Isoenzymes/antagonists & inhibitors ; Mutation ; Pancreas/immunology ; Pancreas/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/pathology ; Prognosis ; Promoter Regions, Genetic/genetics ; Protein Kinase C/antagonists & inhibitors ; Proto-Oncogene Proteins p21(ras)/genetics ; RNA-Seq ; Sp1 Transcription Factor/antagonists & inhibitors ; Sp1 Transcription Factor/metabolism ; Transcriptional Activation/drug effects ; Transcriptional Activation/immunology ; Tumor Escape/drug effects ; Tumor Escape/genetics ; Up-Regulation/drug effects ; Up-Regulation/immunology ; YAP-Signaling Proteins
Czasopismo naukowe
Tytuł :
A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure.
Autorzy :
Eltschkner S; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.; Molecular Ecology and Evolution Lab, Department of Biology, Lund University, 223 62 Lund, Sweden.
Kehrein J; Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Le TA; Institute of Physical and Theoretical Chemistry, University of Würzburg, 97074 Würzburg, Germany.; Department of Experimental Physics 5 (Biophysics), University of Würzburg, 97074 Würzburg, Germany.
Davoodi S; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Merget B; Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Basak S; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Weinrich JD; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.; Department of Microbiology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Schiebel J; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.
Tonge PJ; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Engels B; Institute of Physical and Theoretical Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Sotriffer C; Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Kisker C; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2021 Apr 09; Vol. 7 (4), pp. 746-758. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Isoenzymes*
Enzyme Inhibitors/*pharmacology
Oxidoreductases/*antagonists & inhibitors
Isomerism ; Mycobacterium tuberculosis/enzymology ; Staphylococcus aureus/enzymology
Czasopismo naukowe
Tytuł :
Fabry Disease: The Current Treatment Landscape.
Autorzy :
Lenders M; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, and Interdisciplinary Fabry Center Münster (IFAZ), University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Brand E; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, and Interdisciplinary Fabry Center Münster (IFAZ), University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. .
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Źródło :
Drugs [Drugs] 2021 Apr; Vol. 81 (6), pp. 635-645. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enzyme Replacement Therapy*
1-Deoxynojirimycin/*analogs & derivatives
Fabry Disease/*therapy
Isoenzymes/*metabolism
Recombinant Proteins/*metabolism
alpha-Galactosidase/*metabolism
1-Deoxynojirimycin/administration & dosage ; 1-Deoxynojirimycin/therapeutic use ; Humans ; Isoenzymes/administration & dosage ; Recombinant Proteins/administration & dosage ; alpha-Galactosidase/administration & dosage
Czasopismo naukowe
Tytuł :
Identification of individual components of a commercial wheat germ acid phosphatase preparation.
Autorzy :
Moorman VR; Department of Chemistry and Biochemistry, Kettering University, Flint, Michigan, United States of America.
Brayton AM; Department of Chemistry and Biochemistry, Kettering University, Flint, Michigan, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Mar 22; Vol. 16 (3), pp. e0248717. Date of Electronic Publication: 2021 Mar 22 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acid Phosphatase/*isolation & purification
Germ Cells/*enzymology
Isoenzymes/*isolation & purification
Triticum/*enzymology
Acid Phosphatase/chemistry ; Acid Phosphatase/genetics ; Chromatography, Affinity ; Isoenzymes/genetics ; Kinetics ; Substrate Specificity/genetics
Czasopismo naukowe

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