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Wyświetlanie 61-80 z 20211
Tytuł:
Enzyme Replacement Therapy for FABRY Disease: Possible Strategies to Improve Its Efficacy.
Autorzy:
Iacobucci I; Department of Chemical Sciences, Università degli Studi di Napoli 'Federico II', Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Napoli, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Via G. Salvatore 486, 80131 Napoli, Italy.
Hay Mele B; Department of Biology, University of Napoli 'Federico II', Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Napoli, Italy.
Cozzolino F; Department of Chemical Sciences, Università degli Studi di Napoli 'Federico II', Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Napoli, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Via G. Salvatore 486, 80131 Napoli, Italy.
Monaco V; Department of Chemical Sciences, Università degli Studi di Napoli 'Federico II', Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Napoli, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Via G. Salvatore 486, 80131 Napoli, Italy.
Cimmaruta C; Department of Biology, University of Napoli 'Federico II', Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Napoli, Italy.
Monti M; Department of Chemical Sciences, Università degli Studi di Napoli 'Federico II', Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Napoli, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Via G. Salvatore 486, 80131 Napoli, Italy.
Andreotti G; Institute of Biomolecular Chemistry ICB, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Monticelli M; Department of Biology, University of Napoli 'Federico II', Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Napoli, Italy.; Institute of Biomolecular Chemistry ICB, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.; Department of Environmental, Biological, and Pharmaceutical Sciences and Technologies (DiSTABiF), University of Campania 'Luigi Vanvitelli', Via Vivaldi, 43, 81100 Caserta, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 25; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 25.
Typ publikacji:
Journal Article
MeSH Terms:
Fabry Disease*/metabolism
Humans ; alpha-Galactosidase/metabolism ; Enzyme Replacement Therapy/methods ; Isoenzymes/therapeutic use ; Recombinant Proteins/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, Biological and In Silico Studies of Griseofulvin and Usnic Acid Sulfonamide Derivatives as Fungal, Bacterial and Human Carbonic Anhydrase Inhibitors.
Autorzy:
Angeli A; NeuroFarba Department, Sezione di ScienzeFarmaceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.; Istituto di Bioscienze e Biorisorse, CNR (National Research Council), Via Pietro Castellino 111, 80131 Napoli, Italy.
Petrou A; Department of Pharmacy, School of Health, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Kartsev V; InterBioScreen, Chernogolovka 142432, Russia.
Lichitsky B; Zelinsky Institute of Organic Chemistry, Leninsky Prospect, Moscow 119991, Russia.
Komogortsev A; Zelinsky Institute of Organic Chemistry, Leninsky Prospect, Moscow 119991, Russia.
Capasso C; Istituto di Bioscienze e Biorisorse, CNR (National Research Council), Via Pietro Castellino 111, 80131 Napoli, Italy.
Geronikaki A; Department of Pharmacy, School of Health, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Supuran CT; NeuroFarba Department, Sezione di ScienzeFarmaceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 01; Vol. 24 (3). Date of Electronic Publication: 2023 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Carbonic Anhydrase Inhibitors*/chemistry
Griseofulvin*/pharmacology
Humans ; Structure-Activity Relationship ; Carbon Dioxide ; Isoenzymes/metabolism ; Sulfonamides/chemistry ; Carbonic Anhydrase IX/metabolism ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality.
Autorzy:
Wei B; Department of ICU, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yu L; Department of ICU, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło:
Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2020 Dec; Vol. 80 (8), pp. 659-666. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Gram-Negative Bacterial Infections/*genetics
Gram-Positive Bacterial Infections/*genetics
Isoenzymes/*genetics
MicroRNAs/*genetics
Mycoses/*genetics
Protein Kinase C/*genetics
RNA, Circular/*genetics
Sepsis/*genetics
APACHE ; Adult ; Aged ; Biomarkers ; C-Reactive Protein/metabolism ; Case-Control Studies ; Creatinine/blood ; Critical Illness ; Female ; Gene Expression Regulation ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/mortality ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/microbiology ; Gram-Positive Bacterial Infections/mortality ; Humans ; Isoenzymes/blood ; Leukocyte Count ; Male ; MicroRNAs/blood ; Middle Aged ; Mycoses/diagnosis ; Mycoses/microbiology ; Mycoses/mortality ; Prognosis ; Protein Kinase C/blood ; RNA, Circular/blood ; Risk ; Sepsis/diagnosis ; Sepsis/microbiology ; Sepsis/mortality ; Serum Albumin/metabolism ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile.
Autorzy:
Sharonova T; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
Zhmurov P; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
Kalinin S; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
Nocentini A; Neurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.
Angeli A; Neurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.
Ferraroni M; Neurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.
Korsakov M; Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russia.
Supuran CT; Neurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.
Krasavin M; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 857-865.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Sulfonamides/*pharmacology
Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis, molecular modelling and QSAR study of new N- phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity.
Autorzy:
Said MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
George RF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Petreni A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy.
Mohamed NM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Modern University for Technology and Information MTI, Cairo, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 701-717.
Typ publikacji:
Journal Article
MeSH Terms:
Quantitative Structure-Activity Relationship*
Acetanilides/*pharmacology
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Indoles/*pharmacology
Sulfonamides/*pharmacology
Acetanilides/chemical synthesis ; Acetanilides/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Models, Molecular ; Molecular Structure ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Acipimox inhibits human carbonic anhydrases.
Autorzy:
Mori M; Department of Biotechnology, Chemistry and Pharmacy, 'Department of Excellence 2018-2022', University of Siena, Siena, Italy.
Supuran CT; Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Italy.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 672-679.
Typ publikacji:
Journal Article
MeSH Terms:
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Pyrazines/*pharmacology
Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Models, Molecular ; Molecular Structure ; Pyrazines/chemical synthesis ; Pyrazines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases.
Autorzy:
Fuentes-Aguilar A; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Merino-Montiel P; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Montiel-Smith S; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Meza-Reyes S; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Vega-Báez JL; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Puerta A; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, La Laguna, Spain.
Fernandes MX; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, La Laguna, Spain.
Padrón JM; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, La Laguna, Spain.
Petreni A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Florence, Italy.
Nocentini A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Florence, Italy.
Supuran CT; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Florence, Italy.
López Ó; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Fernández-Bolaños JG; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 168-177.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Benzoxazoles/*pharmacology
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Coumarins/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzoxazoles/chemical synthesis ; Benzoxazoles/chemistry ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chromosomes in the African frog genus Tomopterna (Pyxicephalidae) and probing the origin of tetraploid Tomopterna tandyi .
Autorzy:
Bogart JP; Department of Integrative Biology, University of Guelph, ON, Canada.
Dawood A; Office of the Deputy Vice-Chancellor: Research, Innovation and Engagement, Tshwane University of Technology, Pretoria, South Africa.
Becker FS; National Museum of Namibia, P.O. Box 147, Windhoek, Namibia.
Channing A; Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa.
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Źródło:
Genome [Genome] 2022 Dec 01; Vol. 65 (12), pp. 585-604. Date of Electronic Publication: 2022 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Triploidy*
Tetraploidy*
Animals ; Male ; Isoenzymes/genetics ; Australia ; Anura/genetics ; Diploidy ; Chromosomes ; Polyploidy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Short divalent ethacrynic amides as pro-inhibitors of glutathione S -transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers.
Autorzy:
Xu B; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.; Department of Pharmacy, University-Town Hospital of Chongqing Medical University, Chongqing, China.
Tong T; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Wang X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Liu F; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Zhang X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Hu X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Li X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Yang X; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Liao F; Key Laboratory of Clinical Laboratory Diagnostics of the Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 728-742.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Cisplatin/*pharmacology
Ethacrynic Acid/*pharmacology
Ethylenediamines/*pharmacology
Glutathione Transferase/*antagonists & inhibitors
Ovarian Neoplasms/*drug therapy
Putrescine/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cisplatin/chemistry ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Ethacrynic Acid/chemistry ; Ethylenediamines/chemistry ; Female ; Glutathione Transferase/metabolism ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Mice ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Putrescine/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
DIAGNOSTIC PERFORMANCE OF LACTATE DEHYDROGENASE (LDH) ISOENZYMES LEVELS FOR THE SEVERITY OF COVID-19.
Autorzy:
Ergenc, Ilkay
Capar, Emre
Sengel, Buket Erturk
Bahramzade, Gunel
Atalah, Fatih
Kocakaya, Derya
Karakurt, Sait
Haklar, Goncagul
Odabasi, Zekaver
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Alternatywny tytuł:
DIJAGNOSTIČKI ZNAČAJ NIVOA IZOENZIMA LAKTAT DEHIDROGENAZE (LDH) ZA PROCENU TEŽINE COVID-19.
Źródło:
Journal of Medical Biochemistry. 2023, Vol. 42 Issue 1, p16-26. 11p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Interaction of Innate and Adaptive Immunity and Stabilization of Mast Cell Activation in Management of Infusion Related Reactions in Patients with Fabry Disease.
Autorzy:
Limgala RP; Translational Research Unit, Lysosomal and Rare Disorders Research and Treatment Center, Fairfax, VA 22030, USA.
Fikry J; Translational Research Unit, Lysosomal and Rare Disorders Research and Treatment Center, Fairfax, VA 22030, USA.
Veligatla V; Translational Research Unit, Lysosomal and Rare Disorders Research and Treatment Center, Fairfax, VA 22030, USA.
Goker-Alpan O; Translational Research Unit, Lysosomal and Rare Disorders Research and Treatment Center, Fairfax, VA 22030, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 29; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Fabry Disease/*drug therapy
Fabry Disease/*immunology
Inflammation/*immunology
Isoenzymes/*immunology
Recombinant Proteins/*immunology
alpha-Galactosidase/*immunology
Adaptive Immunity/drug effects ; Adaptive Immunity/immunology ; Adolescent ; Adult ; Child ; Enzyme Replacement Therapy/adverse effects ; Fabry Disease/genetics ; Fabry Disease/pathology ; Humans ; Immunity, Innate/drug effects ; Immunity, Innate/immunology ; Immunoglobulin E/immunology ; Inflammation/pathology ; Injection Site Reaction/genetics ; Injection Site Reaction/immunology ; Isoenzymes/administration & dosage ; Male ; Mast Cells/drug effects ; Mast Cells/immunology ; Middle Aged ; Recombinant Proteins/administration & dosage ; Young Adult ; alpha-Galactosidase/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expressions of glutathione S-transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea.
Autorzy:
Takci Z; Department of Dermatology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.
Gunes Bilgili S; Department of Dermatology, Faculty of Medicine, Yuzuncuyıl University, Van, Turkey.
Kilic M; Department of Pharmacy Services, Ankara University, Vocational School of Health Services, Ankara, Turkey.
Oguztuzun S; Department of Biology, Kirikkale University, Kirikkale, Turkey.
Bozer B; Department of Biology, Hitit University, Corum, Turkey.
Guler Simsek G; Department of Pathology, HSU Kecioren Research and Training Hospital, Ankara, Turkey.
Akbayrak A; Department of Dermatology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.
Yıldız Seckin H; Department of Dermatology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.
Karadag AS; Department of Dermatology, Medical Faculty, Istanbul Medeniyet University, Göztepe Research and Training Hospital, Istanbul, Turkey.
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Źródło:
Journal of cosmetic dermatology [J Cosmet Dermatol] 2020 Aug; Vol. 19 (8), pp. 2070-2075. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji:
Journal Article
MeSH Terms:
Isoenzymes*/metabolism
Rosacea*
Adult ; Female ; Glutathione S-Transferase pi/metabolism ; Glutathione Transferase/metabolism ; Humans ; Male ; Middle Aged ; Oxidation-Reduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Osteogenic cocktail induces calcifications in human breast cancer cell line via placental alkaline phosphatase expression.
Autorzy:
Fushimi A; Core Research Facilities, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan. .; Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan. .
Takeyama H; Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Tachibana T; Core Research Facilities, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Manome Y; Core Research Facilities, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 29; Vol. 10 (1), pp. 12669. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alkaline Phosphatase/*genetics
Breast Neoplasms/*genetics
Calcinosis/*genetics
Gene Expression Profiling/*methods
Isoenzymes/*genetics
Alkaline Phosphatase/metabolism ; Animals ; Breast Neoplasms/metabolism ; Calcinosis/metabolism ; Cell Differentiation ; Cell Line, Tumor ; Female ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; Humans ; Isoenzymes/metabolism ; Mice ; Oligonucleotide Array Sequence Analysis ; Phosphorylation ; Proto-Oncogene Proteins c-jun/metabolism ; RNA, Small Interfering/pharmacology ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism.
Autorzy:
Carlisle SM; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA.; Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Trainor PJ; Division of Cardiovascular Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.; Applied Statistics, EASIB Department, New Mexico State University, Las Cruces, NM, USA.
Hong KU; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA.
Doll MA; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA.
Hein DW; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 17; Vol. 10 (1), pp. 9804. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Arylamine N-Acetyltransferase/*metabolism
Breast Neoplasms/*enzymology
Isoenzymes/*metabolism
Acetylation ; Analysis of Variance ; Arylamine N-Acetyltransferase/genetics ; CRISPR-Cas Systems ; Cell Line, Tumor ; Chromatography, Liquid ; Female ; Gene Knockout Techniques ; Humans ; Isoenzymes/genetics ; Metabolic Networks and Pathways/genetics ; Metabolome/genetics ; Substrate Specificity ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2.
Autorzy:
Shi X; Department of Emergency, Tianjin First Center Hospital, Tianjin, China.
Ma W; Department of Anatomy, Dalian Medical University, Dalian, Liaoning, China.
Li Y; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Wang H; Department of Vascular Surgery, Dalian University Affiliated Xinhua Hospital, Dalian, Liaoning, China.
Pan S; Department of Physiology, School of Basic Medicine, Jinzhou Medicine University, Jinzhou, Liaoning, China.
Pan Y; Department of Vascular Surgery, The second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Xu C; Department of General Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
Li L; Department of Vascular Surgery, The second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
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Źródło:
BioFactors (Oxford, England) [Biofactors] 2020 May; Vol. 46 (3), pp. 475-486. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Hexokinase/*genetics
Inflammation/*prevention & control
Isoenzymes/*genetics
MicroRNAs/*genetics
Protein Kinase C/*genetics
Zinc Finger E-box Binding Homeobox 2/*metabolism
Adolescent ; Adult ; Aged ; Cell Survival/genetics ; Female ; Hexokinase/blood ; Humans ; Inflammation/blood ; Inflammation/genetics ; Isoenzymes/blood ; Lipopolysaccharides ; Male ; Middle Aged ; Protein Kinase C/blood ; Signal Transduction/genetics ; Up-Regulation/genetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences.
Autorzy:
Chen J; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.
Qin L; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
Wu X; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
Tan D; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
Lu Y; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
Du Y; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
Wu D; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
He Y; Guizhou Engineering Research Center of Industrial Key-Technology for Dendrobium Nobile, Zunyi Medical University, Zunyi 563000, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 11; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Glucuronides*/metabolism
Tandem Mass Spectrometry*
Humans ; Rats ; Animals ; Chromatography, Liquid ; Kinetics ; Species Specificity ; Isoenzymes/metabolism ; Microsomes, Liver/metabolism ; Glucuronosyltransferase/metabolism ; UDP-Glucuronosyltransferase 1A9 ; Uridine Diphosphate/metabolism
Czasopismo naukowe
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Tytuł:
Sulfation of hyperoside by the human cytosolic sulfotransferases (SULTs): impact of genetic polymorphisms on hyperoside-sulfating activity of SULT1C4 allozymes.
Autorzy:
Mei X; Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH 43614, USA.; School of Pharmacy, Institute of Material Medica, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
Gohal SA; Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH 43614, USA.
Zhou CY; School of Pharmacy, Institute of Material Medica, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
Liu MC; Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH 43614, USA.
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Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2023 Jan; Vol. 25 (1), pp. 75-84. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Sulfotransferases*/genetics
Sulfotransferases*/metabolism
Sulfates*/metabolism
Humans ; Isoenzymes ; Hep G2 Cells ; Caco-2 Cells ; Polymorphism, Genetic
Czasopismo naukowe
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Tytuł:
Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human.
Autorzy:
Boukouvala S; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Chasapopoulou Z; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Giannouri D; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Kontomina E; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Marinakis N; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Rizou SV; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Stefani I; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Tsirka T; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.
Veyssière C; CNRS, Université P. Sabatier, IRD, UMR5174 EDB lab (Laboratoire Evolution & Diversité Biologique), Toulouse, France.
Zaliou S; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece.; Medicon Hellas S.A., Gerakas Attikis, Greece.
Sabbagh A; UMR 261 MERIT IRD, Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Crouau-Roy B; CNRS, Université P. Sabatier, IRD, UMR5174 EDB lab (Laboratoire Evolution & Diversité Biologique), Toulouse, France.
Fakis G; Democritus University of Thrace, Department of Molecular Biology and Genetics, Alexandroupolis, Greece. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jul 29; Vol. 9 (1), pp. 10937. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Polymorphism, Single Nucleotide*
Arylamine N-Acetyltransferase/*genetics
Isoenzymes/*genetics
Animals ; Arylamine N-Acetyltransferase/chemistry ; Arylamine N-Acetyltransferase/metabolism ; Enzyme Stability ; Evolution, Molecular ; Humans ; Isoenzymes/chemistry ; Isoenzymes/metabolism ; Macaca mulatta ; Mutation ; Xenobiotics/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 61-80 z 20211

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