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Wyświetlanie 1-20 z 249
Tytuł:
Cyclooxygenase Isoform Exchange Blocks Brain-Mediated Inflammatory Symptoms.
Autorzy:
Björk Wilhelms D; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.; Division of Drug Research/Emergency Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.; Department of Emergency Medicine, Linköping University Hospital, Linköping, Sweden.
Mirrasekhian E; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Zajdel J; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Kumar Singh A; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Engblom D; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
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Źródło:
PloS one [PLoS One] 2016 Nov 18; Vol. 11 (11), pp. e0166153. Date of Electronic Publication: 2016 Nov 18 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Phenotype*
Brain/*metabolism
Inflammation/*diagnosis
Inflammation/*metabolism
Prostaglandin-Endoperoxide Synthases/*metabolism
Animals ; Brain/pathology ; Cyclooxygenase 1/genetics ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Disease Models, Animal ; Gene Expression ; Inflammation/etiology ; Isoenzymes ; Lipopolysaccharides/adverse effects ; Mice ; Mice, Knockout ; Prostaglandin-Endoperoxide Synthases/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Induction of cyclooxygenase 2 by Escherichia coli but not Helicobacter pylori lipopolysaccharide in gastric epithelial cells in vitro.
Autorzy:
Smith GV; Department of Adult and Paediatric Gastroenterology, St Barts and the London, Queen Mary's School of Medicine, London, UK.
Moran AP
Bajaj-Elliott M
Farthing MJ
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Źródło:
Helicobacter [Helicobacter] 2003; Vol. 8 (5), pp. 513-20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Escherichia coli/*chemistry
Gastric Mucosa/*enzymology
Helicobacter pylori/*chemistry
Isoenzymes/*biosynthesis
Lipopolysaccharides/*toxicity
Prostaglandin-Endoperoxide Synthases/*biosynthesis
Cell Line, Tumor ; Cell Survival ; Cyclooxygenase 2 ; Dinoprostone/biosynthesis ; Enzyme Induction ; Gastric Mucosa/metabolism ; Gastric Mucosa/microbiology ; Helicobacter pylori/pathogenicity ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Lipopolysaccharides/isolation & purification ; Membrane Proteins ; Prostaglandin-Endoperoxide Synthases/genetics ; Prostaglandin-Endoperoxide Synthases/metabolism ; RNA, Messenger/biosynthesis ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer.
Autorzy:
Badawi AF; Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. af_ />Habib SL
Mohammed MA
Abadi AA
Michael MS
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Źródło:
Cancer investigation [Cancer Invest] 2002; Vol. 20 (5-6), pp. 651-6.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Dinoprostone/*biosynthesis
Isoenzymes/*biosynthesis
Prostaglandin-Endoperoxide Synthases/*biosynthesis
Smoking/*adverse effects
Urinary Bladder Neoplasms/*physiopathology
Aged ; Case-Control Studies ; Culture Techniques ; Cyclooxygenase 2 ; Female ; Humans ; Isoenzymes/genetics ; Isoenzymes/pharmacology ; Male ; Membrane Proteins ; Middle Aged ; Polymerase Chain Reaction ; Prostaglandin-Endoperoxide Synthases/genetics ; Prostaglandin-Endoperoxide Synthases/pharmacology ; RNA, Messenger ; Urothelium/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Constitutive and functional expression of cyclooxygenase 2 in the murine proximal colon.
Autorzy:
Porcher C; Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV, USA. />Horowitz B
Ward SM
Sanders KM
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Źródło:
Neurogastroenterology and motility [Neurogastroenterol Motil] 2004 Dec; Vol. 16 (6), pp. 785-99.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Colon/*metabolism
Isoenzymes/*biosynthesis
Muscle, Smooth/*metabolism
Prostaglandin-Endoperoxide Synthases/*biosynthesis
Animals ; Blotting, Western ; Colon/innervation ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/pharmacology ; Immunohistochemistry ; Isoenzymes/genetics ; Mice ; Mice, Knockout ; Muscle Contraction/drug effects ; Muscle Contraction/physiology ; Muscle, Smooth/innervation ; Myenteric Plexus/metabolism ; Neurons/metabolism ; Prostaglandin-Endoperoxide Synthases/genetics ; Prostaglandins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibitory action of ethanol on cyclooxygenase-2 expression through suppression of the extracellular signal-related kinase-mediated pathway in rat alveolar macrophages.
Autorzy:
Kato H; Department of Hygiene & Preventive Medicine, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan.
Negoro M
Wakabayashi I
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2004 Nov; Vol. 95 (5), pp. 226-33.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Enzyme Inhibitors/*pharmacology
Ethanol/*pharmacology
Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors
Isoenzymes/*biosynthesis
Macrophages, Alveolar/*drug effects
Prostaglandin-Endoperoxide Synthases/*biosynthesis
Animals ; Blotting, Western ; Cell Survival/drug effects ; Cells, Cultured ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/pharmacology ; Dinoprostone/metabolism ; Dose-Response Relationship, Drug ; Isoenzymes/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Macrophages, Alveolar/enzymology ; Nitric Oxide Synthase/antagonists & inhibitors ; Rats ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance.
Autorzy:
Buccoliero AM; Department of Human Pathology and Oncology, Medical School, University of Florence, Florence, Italy. />Caldarella A
Arganini L
Mennonna P
Gallina P
Taddei A
Taddei GL
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Źródło:
Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2004 Sep; Vol. 24 (3), pp. 201-7.
Typ publikacji:
Journal Article
MeSH Terms:
Isoenzymes/*analysis
Oligodendroglioma/*diagnosis
Oligodendroglioma/*enzymology
Prostaglandin-Endoperoxide Synthases/*analysis
Adult ; Aged ; Cyclooxygenase 2 ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Isoenzymes/biosynthesis ; Male ; Membrane Proteins ; Middle Aged ; Oligodendroglioma/mortality ; Oligodendroglioma/pathology ; Prognosis ; Prostaglandin-Endoperoxide Synthases/biosynthesis ; Retrospective Studies ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity.
Autorzy:
Lee KM; Department of Anatomy, Pain and Neural Injury Research Center, MRC, School of Medicine, Kyungpook National University, 2-101, Dongin-Dong, Daegu, 700-422, South Korea.
Kang BS
Lee HL
Son SJ
Hwang SH
Kim DS
Park JS
Cho HJ
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2004 Jun; Vol. 19 (12), pp. 3375-81.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperalgesia/*physiopathology
Isoenzymes/*biosynthesis
NF-kappa B/*metabolism
Pain/*physiopathology
Prostaglandin-Endoperoxide Synthases/*biosynthesis
Spinal Cord/*pathology
Animals ; Cyclooxygenase 2 ; Enkephalins/biosynthesis ; Enzyme Inhibitors/administration & dosage ; Freund's Adjuvant/toxicity ; Gene Expression ; Hindlimb/drug effects ; Hindlimb/pathology ; Inflammation/chemically induced ; Injections, Spinal ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1/antagonists & inhibitors ; Interleukin-1/metabolism ; Isoenzymes/drug effects ; Male ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/drug effects ; Prostaglandin-Endoperoxide Synthases/drug effects ; Protein Precursors/biosynthesis ; RNA, Messenger/analysis ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Sialoglycoproteins/administration & dosage ; Spinal Cord/drug effects ; Spinal Cord/physiopathology ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Induction of cyclooxygenase-2 expression in human tracheal smooth muscle cells by interleukin-1beta: involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-kappaB.
Autorzy:
Lin CC; Department of Anesthetics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
Sun CC
Luo SF
Tsai AC
Chien CS
Hsiao LD
Lee CW
Hsieh JT
Yang CM
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Źródło:
Journal of biomedical science [J Biomed Sci] 2004 May-Jun; Vol. 11 (3), pp. 377-90.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Enzyme Induction/*physiology
Interleukin-1/*physiology
Isoenzymes/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Muscle, Smooth/*enzymology
NF-kappa B/*physiology
Prostaglandin-Endoperoxide Synthases/*metabolism
Trachea/*enzymology
Base Sequence ; Bridged-Ring Compounds/pharmacology ; Calcium/metabolism ; Cells, Cultured ; Cyclooxygenase 2 ; DNA Primers ; Dinoprostone/biosynthesis ; Enzyme Inhibitors/pharmacology ; Estrenes/pharmacology ; Genistein/pharmacology ; Humans ; Isoenzymes/biosynthesis ; Membrane Proteins ; Muscle, Smooth/cytology ; Muscle, Smooth/drug effects ; Norbornanes ; Phosphorylation ; Prostaglandin-Endoperoxide Synthases/biosynthesis ; Protein Kinase C/antagonists & inhibitors ; Pyrrolidinones/pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; Thiocarbamates ; Thiones/pharmacology ; Trachea/cytology ; Trachea/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma.
Autorzy:
Hashimoto Y; Department of Urology, Central Institute for Electron Microscopic Research, Kitasato University, Tokyo, Japan.
Kondo Y
Kimura G
Matsuzawa I
Sato S
Ishizaki M
Imura N
Akimoto M
Hara S
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Źródło:
Histopathology [Histopathology] 2004 Apr; Vol. 44 (4), pp. 353-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor*
Carcinoma, Renal Cell/*enzymology
Carcinoma, Renal Cell/*pathology
Isoenzymes/*biosynthesis
Kidney Neoplasms/*enzymology
Kidney Neoplasms/*pathology
Prostaglandin-Endoperoxide Synthases/*biosynthesis
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/ultrastructure ; Cyclooxygenase 2 ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Isoenzymes/genetics ; Kidney Neoplasms/ultrastructure ; Male ; Membrane Proteins ; Microscopy, Immunoelectron ; Middle Aged ; Neoplasm Staging ; Prostaglandin-Endoperoxide Synthases/genetics ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
IFN-gamma-mediated inhibition of COX-2 expression in the placenta from term and preterm labor pregnancies.
Autorzy:
Hanna N; Division of Neonatology, Department of Pediatrics, UMDNJ-Robert Wood, Johnson Medical School, New Brunswick, NJ 08903, USA. />Bonifacio L
Reddy P
Hanna I
Weinberger B
Murphy S
Laskin D
Sharma S
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Źródło:
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2004 Apr; Vol. 51 (4), pp. 311-8.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Interferon-gamma/*physiology
Isoenzymes/*metabolism
Placenta/*metabolism
Prostaglandin-Endoperoxide Synthases/*metabolism
Adolescent ; Adult ; Blotting, Western ; Cyclooxygenase 2 ; DNA-Binding Proteins/analysis ; DNA-Binding Proteins/metabolism ; Decidua/chemistry ; Dinoprostone/analysis ; Dinoprostone/metabolism ; Female ; Humans ; Immunohistochemistry ; Interferon-gamma/analysis ; Interferon-gamma/pharmacology ; Isoenzymes/analysis ; Labor, Obstetric ; Membrane Proteins ; Obstetric Labor, Premature ; Phosphorylation ; Placenta/chemistry ; Placenta/drug effects ; Pregnancy ; Pregnancy Trimester, First/metabolism ; Pregnancy Trimester, Second/metabolism ; Prostaglandin-Endoperoxide Synthases/analysis ; Receptors, Interferon/analysis ; Receptors, Interferon/metabolism ; STAT1 Transcription Factor ; Trans-Activators/analysis ; Trans-Activators/metabolism ; Interferon gamma Receptor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Bone anabolic responses to mechanical load in vitro involve COX-2 and constitutive NOS.
Autorzy:
Kunnel JG; Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA.
Igarashi K
Gilbert JL
Stern PH
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Źródło:
Connective tissue research [Connect Tissue Res] 2004; Vol. 45 (1), pp. 40-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Isoenzymes/*metabolism
Nitric Oxide Synthase/*metabolism
Prostaglandin-Endoperoxide Synthases/*metabolism
Signal Transduction/*physiology
Tibia/*physiology
Weight-Bearing/*physiology
Animals ; Animals, Newborn ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/pharmacology ; Enzyme Inhibitors/pharmacology ; Equipment Design ; In Vitro Techniques ; Indomethacin/pharmacology ; Isoenzymes/antagonists & inhibitors ; Mice ; Mice, Inbred Strains ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase Type I ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; Tibia/drug effects ; Tibia/enzymology ; omega-N-Methylarginine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer.
Autorzy:
Brattström D; Department of Oncology Radiology, Section for Oncology, Uppsala University Hospital, Uppsala, Sweden. />Wester K
Bergqvist M
Hesselius P
Malmström PU
Nordgren H
Wagenius G
Brodin O
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Źródło:
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2004; Vol. 43 (1), pp. 80-6.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor/*analysis
Carcinoma, Non-Small-Cell Lung/*mortality
ErbB Receptors/*metabolism
Isoenzymes/*metabolism
Lung Neoplasms/*mortality
Prostaglandin-Endoperoxide Synthases/*metabolism
Receptor, ErbB-2/*metabolism
Adult ; Aged ; Aged, 80 and over ; Biopsy, Needle ; Capillaries/physiopathology ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cohort Studies ; Cyclooxygenase 2 ; ErbB Receptors/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Isoenzymes/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Membrane Proteins ; Middle Aged ; Neoplasm Staging ; Pneumonectomy ; Probability ; Prognosis ; Proportional Hazards Models ; Prostaglandin-Endoperoxide Synthases/genetics ; Receptor, ErbB-2/genetics ; Retrospective Studies ; Sensitivity and Specificity ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 249

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