Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Ukraiński (UK)
Przejdź do strony domowej biblioteki Uniwersytet Ekonomiczny we Wrocławiu Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaUniwersytet Ekonomiczny we Wrocławiu

Wyszukujesz frazę ""Isoquinolines"" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-20 z 2875
Tytuł:
Ripasudil as a Potential Therapeutic Agent in Treating Secondary Glaucoma in HTLV-1-Uveitis: An In Vitro Analysis.
Autorzy:
Yang M; Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Kamoi K; Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Zong Y; Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Zhang J; Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Zou Y; Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Ohno-Matsui K; Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 12; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Human T-lymphotropic virus 1*
Glaucoma*/drug therapy
Glaucoma*/etiology
Uveitis*
Isoquinolines*
Sulfonamides*
Adult ; Humans ; NF-kappa B ; Cytokines/therapeutic use ; Interleukin-6 ; rho-Associated Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Concise and Free-Metal Access to Lactone-Annelated Pyrrolo[2,1- a ]isoquinoline Derivatives via a 1,2-Rearrangement Step.
Autorzy:
Obydennik AY; Organic Chemistry Department, Science Faculty, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russia.
Titov AA; Organic Chemistry Department, Science Faculty, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russia.
Listratova AV; Organic Chemistry Department, Science Faculty, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russia.
Borisova TN; Organic Chemistry Department, Science Faculty, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russia.
Rybakov VB; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow 119991, Russia.
Voskressensky LG; Organic Chemistry Department, Science Faculty, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russia.
Varlamov AV; Organic Chemistry Department, Science Faculty, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russia.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 16; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Lactones*
Isoquinolines*
Spironolactone ; Acetic Acid ; Metals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis of 1-Aminoisoquinolines and Their Application in a Host-Guest Doped Strategy To Construct Ultralong Room-Temperature Phosphorescence Materials for Bioimaging.
Autorzy:
Chen L; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Xiong W; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Ma Y; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Ge JY; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Lv N; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Wu X; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325035, P. R. China.
Chen J; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Chen Z; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Pokaż więcej
Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jan 24; Vol. 29 (5), pp. e202202909. Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
Isoquinolines*
Benzophenones*
Temperature
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4- g ]isoquinolines.
Autorzy:
Defois M; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.
Rémondin C; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.
Josselin B; Sorbonne Université, CNRS, Plateforme de Criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Protein Phosphorylation and Human Diseases Unit, Station Biologique, Place Georges Teissier, F-29688 Roscoff, France.; Sorbonne Université/CNRS UMR8227, Station Biologique, Place Georges Teissier, CS90074, CEDEX, F-29688 Roscoff, France.
Nauton L; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.
Théry V; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.
Anizon F; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.
Ruchaud S; Sorbonne Université/CNRS UMR8227, Station Biologique, Place Georges Teissier, CS90074, CEDEX, F-29688 Roscoff, France.
Giraud F; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.
Moreau P; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Aug 30; Vol. 27 (17). Date of Electronic Publication: 2022 Aug 30.
Typ publikacji:
Journal Article
MeSH Terms:
Isoquinolines*/pharmacology
Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Safety, efficacy, and patient selection of ripasudil in patients with uncontrolled glaucoma with maximum conventional medical therapy.
Autorzy:
Jethva J; M & J Western Regional Institute of Ophthalmology, Civil Hospital, Ahmedabad, Gujarat, India.
Bhagat P; M & J Western Regional Institute of Ophthalmology, Civil Hospital, Ahmedabad, Gujarat, India.
Prajapati K; M & J Western Regional Institute of Ophthalmology, Civil Hospital, Ahmedabad, Gujarat, India.
Tank G; Department of Ophthalmology, The Sheth L.G Municipal Hospital, Maninagar, Ahmedabad, Gujarat, India.
Pokaż więcej
Źródło:
Indian journal of ophthalmology [Indian J Ophthalmol] 2022 Jun; Vol. 70 (6), pp. 2020-2023.
Typ publikacji:
Journal Article
MeSH Terms:
Glaucoma*/drug therapy
Isoquinolines*/therapeutic use
Female ; Humans ; Male ; Ophthalmic Solutions ; Patient Selection ; Prospective Studies ; Sulfonamides ; rho-Associated Kinases/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The efficacy and safety of roxadustat for the treatment of anemia in non-dialysis dependent chronic kidney disease patients: An updated systematic review and meta-analysis of randomized clinical trials.
Autorzy:
Abdelazeem B; McLaren Health Care, Flint, Michigan, United States of America.; Michigan State University, East Lansing, Michigan, United States of America.
Shehata J; Faculty of Medicine, Cairo University, Cairo, Egypt.
Abbas KS; Faculty of Medicine, Alexandria University, Alexandria, Egypt.
El-Shahat NA; Faculty of Medicine for Girls, Al-Azher University, Cairo, Egypt.
Malik B; McLaren Health Care, Flint, Michigan, United States of America.; Michigan State University, East Lansing, Michigan, United States of America.
Savarapu P; Louisiana State University Health Sciences Center, Monroe, Louisiana, United States of America.
Eltobgy M; The Ohio State University, Columbus, Ohio, United States of America.
Kunadi A; McLaren Health Care, Flint, Michigan, United States of America.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2022 Apr 01; Vol. 17 (4), pp. e0266243. Date of Electronic Publication: 2022 Apr 01 (Print Publication: 2022).
Typ publikacji:
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms:
Anemia*/complications
Anemia*/drug therapy
Glycine*/adverse effects
Glycine*/analogs & derivatives
Glycine*/therapeutic use
Isoquinolines*/adverse effects
Isoquinolines*/therapeutic use
Renal Insufficiency, Chronic*/complications
Renal Insufficiency, Chronic*/drug therapy
Ferritins ; Hepcidins ; Humans ; Iron/therapeutic use ; Randomized Controlled Trials as Topic ; Transferrin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Construction of Mechanofluorochromic and Aggregation-Induced Emission Materials Based on 4-Substituted Isoquinoline Derivatives.
Autorzy:
Wang D; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Chen Y; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Zhu J; Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, P. R. China.
Lei Y; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Zhou Y; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Gao W; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Liu M; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Wu H; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Huang X; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Pokaż więcej
Źródło:
Chemistry, an Asian journal [Chem Asian J] 2022 Apr 01; Vol. 17 (7), pp. e202200054. Date of Electronic Publication: 2022 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorescent Dyes*/chemistry
Isoquinolines*
Molecular Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single-dose NEPA versus an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy.
Autorzy:
Zelek L; Hôpital Avicenne, Bobigny, France.
Navari R; World Health Organization Cancer Care Program, Birmingham, Alabama, USA.
Aapro M; Genolier Cancer Center, Clinique de Genolier, Genolier, Switzerland.
Scotté F; Interdisciplinary Cancer Course Department, Gustave Roussy Cancer Center, Villejuif, France.
Pokaż więcej
Źródło:
Cancer medicine [Cancer Med] 2023 Aug; Vol. 12 (15), pp. 15769-15776. Date of Electronic Publication: 2023 Aug 03.
Typ publikacji:
Randomized Controlled Trial; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiemetics*/therapeutic use
Antineoplastic Agents*/adverse effects
Humans ; Male ; Female ; Aprepitant/therapeutic use ; Vomiting/chemically induced ; Vomiting/prevention & control ; Vomiting/drug therapy ; Prospective Studies ; Isoquinolines ; Quinuclidines ; Drug Combinations ; Nausea/chemically induced ; Nausea/prevention & control ; Nausea/drug therapy ; Cyclophosphamide/therapeutic use ; Anthracyclines/adverse effects ; Dexamethasone
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles.
Autorzy:
Twardy DJ; Department of Chemistry, Oakland University, 146 Library Dr., Rochester, MI 48309, USA.
Wheeler KA; Department of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, WA 99251, USA.
Török B; Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA.
Dembinski R; Department of Chemistry, Oakland University, 146 Library Dr., Rochester, MI 48309, USA.; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Mar 23; Vol. 27 (7). Date of Electronic Publication: 2022 Mar 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Benzimidazoles*/chemistry
Isoquinolines*/chemistry
Cyclization
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B.
Autorzy:
Haidar AK; Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.
Kjeldsen ND; NCK A/S, Rugmarken 28, 3520 Farum, Denmark.
Troelsen NS; Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.
Previtali V; Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.
Lundquist KP; Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.
Larsen TO; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, 2800 Kongens Lyngby, Denmark.
Clausen MH; Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 14; Vol. 27 (2). Date of Electronic Publication: 2022 Jan 14.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*chemistry
Aspergillus/*chemistry
Benzofurans/*chemical synthesis
Isoquinolines/*chemistry
Benzofurans/chemistry ; Cyclization ; Isoquinolines/chemical synthesis ; Molecular Structure ; Stereoisomerism
SCR Organism:
Aspergillus ustus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice.
Autorzy:
de Jong LM; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Zhang Z; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
den Hartog Y; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Sijsenaar TJP; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Martins Cardoso R; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Manson ML; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Hankemeier T; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Lindenburg PW; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.; Research Group Metabolomics, Leiden Center for Applied Bioscience, University of Applied Sciences Leiden, Leiden, The Netherlands.
Salvatori DCF; Central Laboratory Animal Facility, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Van Eck M; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Hoekstra M; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2022 Jan 10; Vol. 12 (1), pp. 483. Date of Electronic Publication: 2022 Jan 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, Western/*adverse effects
Fatty Liver/*drug therapy
Isoquinolines/*adverse effects
Protein-Arginine N-Methyltransferases/*antagonists & inhibitors
Pruritus/*etiology
Receptors, LDL/*genetics
Triglycerides/*blood
Animals ; Fatty Liver/metabolism ; Humans ; Isoquinolines/therapeutic use ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; Pruritus/genetics ; Pruritus/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, LDL/deficiency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats.
Autorzy:
Shoji H; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.; Department of Respiratory Medicine, Tokyo Rosai Hospital, Tokyo 143-0013, Japan.
Yoshida Y; D. Western Therapeutics Institute, Inc., Nagoya 460-0003, Japan.; Human Research Promotion and Drug Development, Mie University, Mie 514-8507, Japan.
Sanada TJ; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Naito A; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Maruyama J; Department of Anesthesiology and Critical Care Medicine, School of Medicine, Mie University, Mie 514-8507, Japan.; Faculty of Medical Engineering, Suzuka University of Medical Science, Mie 510-0293, Japan.
Zhang E; Department of Anesthesiology and Critical Care Medicine, School of Medicine, Mie University, Mie 514-8507, Japan.
Sumi K; D. Western Therapeutics Institute, Inc., Nagoya 460-0003, Japan.; Human Research Promotion and Drug Development, Mie University, Mie 514-8507, Japan.
Sakao S; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Maruyama K; Department of Anesthesiology and Critical Care Medicine, School of Medicine, Mie University, Mie 514-8507, Japan.
Hidaka H; D. Western Therapeutics Institute, Inc., Nagoya 460-0003, Japan.; Human Research Promotion and Drug Development, Mie University, Mie 514-8507, Japan.
Tatsumi K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Pokaż więcej
Źródło:
Cells [Cells] 2021 Dec 27; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoxia/*complications
Indoles/*adverse effects
Isoquinolines/*therapeutic use
Pulmonary Arterial Hypertension/*drug therapy
Pulmonary Arterial Hypertension/*etiology
Pyrroles/*adverse effects
Sulfonamides/*therapeutic use
Animals ; Cell Proliferation/drug effects ; Heart Ventricles/drug effects ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Humans ; Isoquinolines/pharmacology ; Lung/blood supply ; Lung/pathology ; Male ; Metabolome ; Myosin Light Chains/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Pulmonary Arterial Hypertension/pathology ; Pulmonary Arterial Hypertension/physiopathology ; Rats, Sprague-Dawley ; Sulfonamides/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Vascular Remodeling/drug effects ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells.
Autorzy:
Jaunky DB; Department of Biology, Concordia University, Montreal, QC, Canada.
Larocque K; Department of Biology, Concordia University, Montreal, QC, Canada.
Husser MC; Department of Biology, Concordia University, Montreal, QC, Canada.
Liu JT; Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada.
Forgione P; Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada.
Piekny A; Department of Biology, Concordia University, Montreal, QC, Canada. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Dec 08; Vol. 11 (1), pp. 23665. Date of Electronic Publication: 2021 Dec 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Isoquinolines/*pharmacology
Microtubules/*drug effects
Mitosis/*drug effects
Spindle Apparatus/*drug effects
Spindle Poles/*drug effects
Cell Line, Tumor ; Cells, Cultured ; Colchicine/pharmacology ; Humans ; Isoquinolines/chemistry ; Microtubules/metabolism ; Thiophenes/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Have (R)-[ C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies.
Autorzy:
Chauveau F; University of Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR5292, INSERM U1028, University Lyon 1, Lyon, France. .
Becker G; GIGA - CRC In Vivo Imaging, University Liege, Liege, Belgium.; University of Lyon, CarMeN Laboratory, INSERM U1060, University Lyon 1, Hospices Civils Lyon, Lyon, France.
Boutin H; Faculty of Biology Medicine and Health, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. .; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. .; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance & University of Manchester, Manchester, UK. .
Pokaż więcej
Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 Dec; Vol. 49 (1), pp. 201-220. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:
Journal Article; Review; Systematic Review
MeSH Terms:
Isoquinolines*
Positron-Emission Tomography*
Brain/metabolism ; Humans ; Radionuclide Imaging ; Receptors, GABA/genetics ; Receptors, GABA/metabolism ; Signal-To-Noise Ratio
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Impact of the Combined Administration of 1MeTIQ and MK-801 on Cell Viability, Oxidative Stress Markers, and Glutamate Release in the Rat Hippocampus.
Autorzy:
Wąsik A; Department of Neurochemistry, Maj Institute of Pharmacology PAS, Krakow, Poland. .
Białoń M; Department of Neurochemistry, Maj Institute of Pharmacology PAS, Krakow, Poland.
Jantas D; Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology PAS, Krakow, Poland.
Żarnowska M; Department of Neurochemistry, Maj Institute of Pharmacology PAS, Krakow, Poland.
Pokaż więcej
Źródło:
Neurotoxicity research [Neurotox Res] 2021 Dec; Vol. 39 (6), pp. 1747-1761. Date of Electronic Publication: 2021 Oct 19.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Survival/*drug effects
Dizocilpine Maleate/*pharmacology
Glutamic Acid/*metabolism
Hippocampus/*drug effects
Isoquinolines/*pharmacokinetics
Oxidative Stress/*drug effects
Animals ; Catalase/metabolism ; Dizocilpine Maleate/administration & dosage ; Glutathione Reductase/metabolism ; Hippocampus/metabolism ; Isoquinolines/administration & dosage ; L-Lactate Dehydrogenase/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of GLPG1205, a GPR84 Modulator, on CYP2C9, CYP2C19, and CYP1A2 Enzymes: In Vitro and Phase 1 Studies.
Autorzy:
Desrivot J; Galapagos, Romainville, France.
Van Kaem T; Galapagos, Mechelen, Belgium.
Allamassey L; Alten Belgium, Brussels, Belgium.
Helmer E; Galapagos Biotech Ltd, Cambridge, UK.
Pokaż więcej
Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Sep; Vol. 10 (9), pp. 1007-1017. Date of Electronic Publication: 2021 May 06.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytochrome P-450 CYP1A2*/drug effects
Cytochrome P-450 CYP1A2*/metabolism
Cytochrome P-450 CYP2C19*/drug effects
Cytochrome P-450 CYP2C19*/metabolism
Cytochrome P-450 CYP2C9*/drug effects
Cytochrome P-450 CYP2C9*/metabolism
Receptors, G-Protein-Coupled*/drug effects
Receptors, G-Protein-Coupled*/metabolism
Isoquinolines*/pharmacology
Isoquinolines*/therapeutic use
Adult ; Humans ; Male ; Middle Aged ; Cross-Over Studies ; Double-Blind Method ; Drug Interactions
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Potential value and chemical characterization of gut microbiota derived nitrogen containing metabolites in feces from Periplaneta americana (L.) at different growth stages.
Autorzy:
Lv W; State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Cui Y; State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Xue G; State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Wang Z; State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Niu L; State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Chai X; State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. .
Wang Y; State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Oct 27; Vol. 11 (1), pp. 21191. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gastrointestinal Microbiome*
Biological Products/*metabolism
Cockroaches/*microbiology
Isoquinolines/*metabolism
Animals ; Biological Products/analysis ; Carboxylic Acids/analysis ; Carboxylic Acids/metabolism ; Cockroaches/growth & development ; Feces/chemistry ; Feces/microbiology ; Isoquinolines/analysis ; Nitrogen/metabolism ; Nymph/growth & development ; Nymph/microbiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Asymmetric Catalytic Synthesis of Hexahydropyrrolo-isoquinolines via Three-Component 1,3-Dipolar-Cycloaddition.
Autorzy:
Li Z; Key Laboratory of Green Chemistry &Technology Ministry of Education, College of Chemistry, Sichuan University, P. R. China.
Xu N; Key Laboratory of Green Chemistry &Technology Ministry of Education, College of Chemistry, Sichuan University, P. R. China.
Guo N; Key Laboratory of Green Chemistry &Technology Ministry of Education, College of Chemistry, Sichuan University, P. R. China.
Zhou Y; Key Laboratory of Green Chemistry &Technology Ministry of Education, College of Chemistry, Sichuan University, P. R. China.
Lin L; Key Laboratory of Green Chemistry &Technology Ministry of Education, College of Chemistry, Sichuan University, P. R. China.
Feng X; Key Laboratory of Green Chemistry &Technology Ministry of Education, College of Chemistry, Sichuan University, P. R. China.
Pokaż więcej
Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Oct 25; Vol. 27 (60), pp. 14841-14845. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji:
Journal Article
MeSH Terms:
Isoquinolines*
Lewis Acids*
Catalysis ; Cycloaddition Reaction ; Stereoisomerism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line.
Autorzy:
Weiner F; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Schille JT; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Koczan D; Core Facility for Microarray Analysis, Institute for Immunology, University of Rostock, 18057, Rostock, Germany.
Wu XF; Leibniz Institute for Catalysis, 18059, Rostock, Germany.
Beller M; Leibniz Institute for Catalysis, 18059, Rostock, Germany.
Junghanss C; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Hewicker-Trautwein M; Department of Pathology, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.
Murua Escobar H; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.; Comprehensive Cancer Center - Mecklenburg Vorpommern (CCC-MV), Campus Rostock, University of Rostock, 18057, Rostock, Germany.
Nolte I; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany. .
Pokaż więcej
Źródło:
BMC cancer [BMC Cancer] 2021 Oct 08; Vol. 21 (1), pp. 1088. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
G1 Phase Cell Cycle Checkpoints/*drug effects
Isoquinolines/*pharmacology
NF-kappa B/*metabolism
Prostatic Neoplasms, Castration-Resistant/*metabolism
Antineoplastic Agents/therapeutic use ; E2F1 Transcription Factor/antagonists & inhibitors ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression/drug effects ; Gene Expression Profiling/methods ; Humans ; Isoquinolines/therapeutic use ; Male ; Middle Aged ; PC-3 Cells ; Plasminogen Activator Inhibitor 1/metabolism ; Prostatic Neoplasms, Castration-Resistant/genetics ; S Phase Cell Cycle Checkpoints ; Time Factors ; Tissue Array Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition.
Autorzy:
Tian S; The State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China.
Wang R; The State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China.
Chen S; The State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China.
He J; The State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China.
Zheng W; The State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China.
Li Y; The State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 03; Vol. 26 (19). Date of Electronic Publication: 2021 Oct 03.
Typ publikacji:
Journal Article
MeSH Terms:
Benzophenanthridines/*chemistry
Isoquinolines/*chemistry
PPAR alpha/*agonists
PPAR gamma/*agonists
Adipogenesis/drug effects ; Adipogenesis/genetics ; Animals ; Benzophenanthridines/pharmacology ; Crystallography, X-Ray ; Gene Expression Regulation ; Genes, Reporter ; HEK293 Cells ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Isoquinolines/pharmacology ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; PPAR alpha/genetics ; PPAR alpha/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 2875

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies