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Tytuł :
Author Correction: Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons.
Autorzy :
Kronman H; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Torres-Berrío A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sidoli S; Department of Biochemistry and Biophysics and Epigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Issler O; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Godino A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ramakrishnan A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mews P; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lardner CK; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Sackler Institute for Developmental Psychobiology, New York State Psychiatric Institute, and Departments of Pediatrics and Psychiatry, Columbia University, New York, NY, USA.
Parise EM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Walker DM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neurobiology and Behavior, Oregon Health & Science University, Portland, OR, USA.
van der Zee YY; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Browne CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Boyce BF; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neve R; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Garcia BA; Department of Biochemistry and Biophysics and Epigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Shen L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peña CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. .
Nestler EJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2021 Apr 08. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Published Erratum
Tytuł :
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons.
Autorzy :
Kronman H; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Torres-Berrío A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sidoli S; Department of Biochemistry and Biophysics and Epigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Issler O; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Godino A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ramakrishnan A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mews P; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lardner CK; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Sackler Institute for Developmental Psychobiology, New York State Psychiatric Institute, and Departments of Pediatrics and Psychiatry, Columbia University, New York NY, USA.
Parise EM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Walker DM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neurobiology and Behavior, Oregon Health & Science University, Portland, OR, USA.
van der Zee YY; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Browne CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Boyce BF; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neve R; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Garcia BA; Department of Biochemistry and Biophysics and Epigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Shen L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peña CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. .
Nestler EJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2021 Mar 15. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression.
Autorzy :
Issler O; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
van der Zee YY; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, 6229 ER, Maastricht, the Netherlands.
Ramakrishnan A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wang J; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Tan C; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Loh YE; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Purushothaman I; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Walker DM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lorsch ZS; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hamilton PJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Peña CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Flaherty E; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hartley BJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Torres-Berrío A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Parise EM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kronman H; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Duffy JE; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Estill MS; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Calipari ES; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Labonté B; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Neve RL; Gene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA 02139, USA.
Tamminga CA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Brennand KJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Shen L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nestler EJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Jun 17; Vol. 106 (6), pp. 912-926.e5. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Resilience, Psychological*
Depressive Disorder, Major/*genetics
Prefrontal Cortex/*metabolism
RNA, Long Noncoding/*genetics
Stress, Psychological/*genetics
Adult ; Aged ; Aged, 80 and over ; Animals ; Behavior, Animal ; Depression/genetics ; Depression/metabolism ; Depressive Disorder, Major/metabolism ; Down-Regulation ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Neurons/metabolism ; RNA, Long Noncoding/metabolism ; RNA-Seq ; Sex Factors ; Stress, Psychological/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Unraveling the epigenetic landscape of depression: focus on early life stress
.
Autorzy :
Torres-Berrío A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
Issler O; Author affiliations: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
Parise EM; Author affiliations: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
Nestler EJ; Author affiliations: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
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Źródło :
Dialogues in clinical neuroscience [Dialogues Clin Neurosci] 2019 Dec; Vol. 21 (4), pp. 341-357.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Depression/*genetics
Depressive Disorder/*genetics
Genetic Predisposition to Disease/*genetics
Stress, Psychological/*genetics
Animals ; DNA Methylation/genetics ; Depression/drug therapy ; Depressive Disorder/drug therapy ; Epigenomics/methods ; Humans
Czasopismo naukowe
Tytuł :
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.
Autorzy :
Lorsch ZS; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hamilton PJ; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ramakrishnan A; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Parise EM; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Salery M; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wright WJ; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Lepack AE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mews P; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Issler O; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
McKenzie A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhou X; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Parise LF; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pirpinias ST; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ortiz Torres I; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kronman HG; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Montgomery SE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Loh YE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Labonté B; Department of Neuroscience and Psychiatry, Laval University, Québec City, Québec, Canada.
Conkey A; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Symonds AE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neve RL; Gene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA, USA.
Turecki G; Department of Psychiatry, McGill University, Montréal, Québec, Canada.; McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Québec, Canada.
Maze I; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shen L; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bagot RC; Department of Psychiatry, McGill University, Montréal, Québec, Canada.; Department of Psychology, McGill University, Montréal, Québec, Canada.; Ludmer Centre for Neuroinformatics and Mental Health, Montréal, Québec, Canada.
Nestler EJ; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2019 Sep; Vol. 22 (9), pp. 1413-1423. Date of Electronic Publication: 2019 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptation, Psychological/*physiology
Stress, Psychological/*genetics
Zinc Fingers/*genetics
Animals ; Gene Regulatory Networks/genetics ; Mice ; Mice, Inbred C57BL ; Prefrontal Cortex/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Gadd45b mediates depressive-like role through DNA demethylation.
Autorzy :
Labonté B; CERVO Brain Research Centre, Department of Neuroscience and Psychiatry, Faculty of Medicine, Laval University, Québec, Canada.
Jeong YH; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41068, Korea.
Parise E; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Issler O; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Fatma M; CERVO Brain Research Centre, Department of Neuroscience and Psychiatry, Faculty of Medicine, Laval University, Québec, Canada.
Engmann O; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Cho KA; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41068, Korea.; Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Neve R; Viral Gene Transfer Core, McGovern Institute for Brain Research, MIT, Cambridge, MA, 02139, USA.
Nestler EJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Koo JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41068, Korea. .
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Źródło :
Scientific reports [Sci Rep] 2019 Mar 15; Vol. 9 (1), pp. 4615. Date of Electronic Publication: 2019 Mar 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Differentiation/*metabolism
DNA Demethylation/*drug effects
Depression/*metabolism
Animals ; Brain-Derived Neurotrophic Factor/metabolism ; DNA/metabolism ; Dopamine/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Nucleus Accumbens/metabolism ; Social Behavior ; Stress, Psychological/physiopathology ; Ventral Tegmental Area/metabolism
Czasopismo naukowe
Tytuł :
Corrigendum: Sex-specific transcriptional signatures in human depression.
Autorzy :
Labonté B
Engmann O
Purushothaman I
Menard C
Wang J
Tan C
Scarpa JR
Moy G
Loh YE
Cahill M
Lorsch ZS
Hamilton PJ
Calipari ES
Hodes GE
Issler O
Kronman H
Pfau M
Obradovic ALJ
Dong Y
Neve RL
Russo S
Kasarskis A
Tamminga C
Mechawar N
Turecki G
Zhang B
Shen L
Nestler EJ
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Źródło :
Nature medicine [Nat Med] 2018 Apr 10; Vol. 24 (4), pp. 525.
Typ publikacji :
Published Erratum
Tytuł :
Estrogen receptor α drives pro-resilient transcription in mouse models of depression.
Autorzy :
Lorsch ZS; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Loh YE; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Purushothaman I; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Walker DM; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Parise EM; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Salery M; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Cahill ME; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Hodes GE; School of Neuroscience, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Blacksburg, VA, 24061, USA.
Pfau ML; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Kronman H; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Hamilton PJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Issler O; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Labonté B; Department of Neuroscience and Psychiatry, Faculty of Medicine, Laval University, 2601 Chemin de la Canardière Québec, QC, G1J 2G3, Canada.
Symonds AE; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Zucker M; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Zhang TY; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Institute, Sackler Program for Epigenetics and Psychobiology, Departments of Psychiatry and Neurology and Neurosurgery, McGill University, 6875 Boulevard Lasalle, Montréal, QC, H4H 1R3, Canada.
Meaney MJ; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Institute, Sackler Program for Epigenetics and Psychobiology, Departments of Psychiatry and Neurology and Neurosurgery, McGill University, 6875 Boulevard Lasalle, Montréal, QC, H4H 1R3, Canada.
Russo SJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Shen L; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Bagot RC; Departments of Psychology & Psychiatry, Ludmer Centre for Neuroinformatics and Mental Health, McGill University, 1205 Avenue Dr Penfield, Montréal, QC, H3A 1B1, Canada.
Nestler EJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA. .
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Źródło :
Nature communications [Nat Commun] 2018 Mar 16; Vol. 9 (1), pp. 1116. Date of Electronic Publication: 2018 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptation, Psychological/*physiology
Behavior, Animal/*physiology
Depression/*physiopathology
Estrogen Receptor alpha/*metabolism
Nucleus Accumbens/*metabolism
Stress, Psychological/*physiopathology
Animals ; Estrogen Receptor alpha/genetics ; Female ; Gene Expression Profiling ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Sex Factors ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.
Autorzy :
Engmann O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Labonté B; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Mitchell A; Departments of Psychiatry and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Bashtrykov P; Institute of Biochemistry, Stuttgart University, Stuttgart, Germany.
Calipari ES; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Rosenbluh C; Departments of Developmental and Regenerative Biology and of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Loh YE; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Walker DM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Burek D; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Hamilton PJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Neve RL; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Turecki G; Douglas Mental Health University Institute, Montreal, Quebec, Canada.
Hurd Y; Departments of Psychiatry and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Chess A; Departments of Developmental and Regenerative Biology and of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Shen L; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Mansuy I; University of Zurich/Eidgenössische Technische Hochschule Zurich Brain Research Institute, Zurich, Switzerland.
Jeltsch A; Institute of Biochemistry, Stuttgart University, Stuttgart, Germany.
Akbarian S; Departments of Psychiatry and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: .
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Źródło :
Biological psychiatry [Biol Psychiatry] 2017 Dec 01; Vol. 82 (11), pp. 794-805. Date of Electronic Publication: 2017 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatin/*drug effects
Cocaine/*administration & dosage
Dopamine Uptake Inhibitors/*administration & dosage
Gene Expression Regulation/*drug effects
Nuclear Proteins/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Cell Line, Tumor ; Cohort Studies ; Conditioning, Operant/drug effects ; Cytoskeletal Proteins ; DNA Methylation/drug effects ; Gene Expression Regulation/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Models, Molecular ; Molecular Conformation ; Neuroblastoma/pathology ; Nuclear Proteins/genetics ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/genetics ; Receptors, Dopamine D2/metabolism ; Transcription Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Sex-specific transcriptional signatures in human depression.
Autorzy :
Labonté B; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Engmann O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Purushothaman I; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Menard C; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Wang J; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tan C; Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Scarpa JR; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Moy G; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Loh YE; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Cahill M; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lorsch ZS; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hamilton PJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Calipari ES; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hodes GE; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kronman H; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Pfau M; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Obradovic ALJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Neve RL; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Russo S; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kazarskis A; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Tamminga C; Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mechawar N; Department of Psychiatry, McGill University, Montreal, Québec, Canada.; McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Turecki G; Department of Psychiatry, McGill University, Montreal, Québec, Canada.; McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Zhang B; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Shen L; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
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Źródło :
Nature medicine [Nat Med] 2017 Sep; Vol. 23 (9), pp. 1102-1111. Date of Electronic Publication: 2017 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptome*
Brain/*metabolism
Depressive Disorder, Major/*genetics
Stress, Psychological/*genetics
Adult ; Aged ; Animals ; Blotting, Western ; Case-Control Studies ; Cerebral Cortex/metabolism ; Disease Models, Animal ; Down-Regulation ; Female ; Hippocampus/metabolism ; Humans ; Immunohistochemistry ; Male ; Mice ; Middle Aged ; Nucleus Accumbens/metabolism ; Patch-Clamp Techniques ; Prefrontal Cortex/metabolism ; Pyramidal Cells/metabolism ; Sequence Analysis, RNA ; Sex Characteristics ; Sex Factors
Czasopismo naukowe
Tytuł :
Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors.
Autorzy :
Feng J; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Pena CJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Purushothaman I; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Engmann O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Walker D; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Brown AN; Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Doyle M; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Harrigan E; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mouzon E; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Vialou V; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shen L; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dawlaty MM; Department of Genetics and Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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Źródło :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2017 Jul; Vol. 42 (8), pp. 1657-1669. Date of Electronic Publication: 2017 Jan 11.
Typ publikacji :
Journal Article
MeSH Terms :
Anxiety/*physiopathology
DNA-Binding Proteins/*physiology
Depression/*physiopathology
Nucleus Accumbens/*metabolism
Proto-Oncogene Proteins/*physiology
Stress, Psychological/*physiopathology
Animals ; Anxiety/genetics ; Behavior, Animal ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Depression/genetics ; Disease Models, Animal ; Gene Expression/genetics ; Male ; Mice ; Mice, Knockout ; Proto-Oncogene Proteins/biosynthesis ; Proto-Oncogene Proteins/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.
Autorzy :
Peña CJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kronman HG; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Walker DM; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cates HM; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bagot RC; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Purushothaman I; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Issler O; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Loh YE; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Leong T; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kiraly DD; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Goodman E; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Neve RL; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shen L; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nestler EJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2017 Jun 16; Vol. 356 (6343), pp. 1185-1188.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation*
Depression/*genetics
Otx Transcription Factors/*genetics
Stress, Physiological/*genetics
Ventral Tegmental Area/*physiopathology
Age Factors ; Animals ; Depression/physiopathology ; Female ; Gene Knockdown Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Protein Binding
Czasopismo naukowe
Tytuł :
Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.
Autorzy :
Lepack AE; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Bagot RC; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Peña CJ; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Loh YE; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Farrelly LA; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Lu Y; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Powell SK; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Lorsch ZS; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Issler O; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Cates HM; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Tamminga CA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75235.
Molina H; The Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY 10065.
Shen L; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Nestler EJ; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Department of Pharmacological Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Allis CD; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065.
Maze I; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029; .; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Department of Pharmacological Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Nov 01; Vol. 113 (44), pp. 12562-12567. Date of Electronic Publication: 2016 Oct 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Depressive Disorder/*physiopathology
Histones/*metabolism
Nucleus Accumbens/*physiopathology
Stress, Psychological/*physiopathology
Adult ; Aged ; Animals ; Depressive Disorder/genetics ; Depressive Disorder/metabolism ; Female ; Gene Expression Regulation ; Gene Knockdown Techniques ; Histones/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Nucleus Accumbens/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Stress, Psychological/genetics
Czasopismo naukowe
Tytuł :
Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine.
Autorzy :
Kiraly DD; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Walker DM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Calipari ES; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Labonte B; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Pena CJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ribeiro EA; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Russo SJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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Źródło :
Scientific reports [Sci Rep] 2016 Oct 18; Vol. 6, pp. 35455. Date of Electronic Publication: 2016 Oct 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Microbiota*/drug effects
Behavior, Animal/*drug effects
Cocaine/*pharmacology
Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Cocaine/metabolism ; Corticosterone/blood ; Corticosterone/metabolism ; Dopamine/metabolism ; Gastrointestinal Microbiome/drug effects ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Glutamic Acid/metabolism ; Male ; Mice ; Transcriptome
Czasopismo naukowe
Tytuł :
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility.
Autorzy :
Bagot RC; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cates HM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Purushothaman I; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lorsch ZS; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Walker DM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wang J; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Huang X; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Schlüter OM; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Maze I; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Peña CJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Heller EA; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wang M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Song WM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Stein JL; Department of Genetics and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Liu X; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Doyle MA; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Scobie KN; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sun HS; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Neve RL; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Geschwind D; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Shen L; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2016 Jun 01; Vol. 90 (5), pp. 969-83. Date of Electronic Publication: 2016 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Regulatory Networks*
Transcriptome*
Brain/*metabolism
Depression/*genetics
Genetic Predisposition to Disease/*genetics
Neural Pathways/*metabolism
Animals ; Depression/metabolism ; Excitatory Postsynaptic Potentials/physiology ; Hippocampus/physiology ; Mice ; Social Behavior
Czasopismo naukowe
Tytuł :
Determining the role of microRNAs in psychiatric disorders.
Autorzy :
Issler O; 1] The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. [2] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Chen A; 1] The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. [2] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
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Źródło :
Nature reviews. Neuroscience [Nat Rev Neurosci] 2015 Apr; Vol. 16 (4), pp. 201-12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Behavior/*physiology
Brain/*metabolism
Mental Disorders/*genetics
MicroRNAs/*genetics
Animals ; Humans ; Mental Disorders/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity.
Autorzy :
Issler O; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel; Department of Stress Neurobiology and Neurogenetics, Max-Planck Institute of Psychiatry, 80804 Munich, Germany.
Haramati S; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Paul ED; Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.
Maeno H; Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Navon I; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Zwang R; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Gil S; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Mayberg HS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Dunlop BW; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Menke A; Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, 80804 Munich, Germany.
Awatramani R; Department of Neurology and Center for Genetic Medicine, Northwestern University Feinberg Medical School, Chicago, IL 60611, USA.
Binder EB; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, 80804 Munich, Germany.
Deneris ES; Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Lowry CA; Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.
Chen A; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel; Department of Stress Neurobiology and Neurogenetics, Max-Planck Institute of Psychiatry, 80804 Munich, Germany. Electronic address: .
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Źródło :
Neuron [Neuron] 2014 Jul 16; Vol. 83 (2), pp. 344-360. Date of Electronic Publication: 2014 Jun 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Resilience, Psychological*
Antidepressive Agents/*therapeutic use
Brain/*drug effects
Depression/*drug therapy
MicroRNAs/*genetics
Serotonin/*metabolism
Stress, Psychological/*genetics
Animals ; Antidepressive Agents/pharmacology ; Anxiety/genetics ; Anxiety/metabolism ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Brain/metabolism ; Depression/genetics ; Depression/metabolism ; Mice ; Mice, Transgenic ; MicroRNAs/metabolism ; Receptor, Serotonin, 5-HT1A/genetics ; Receptor, Serotonin, 5-HT1A/metabolism ; Serotonergic Neurons/drug effects ; Serotonergic Neurons/metabolism ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Social Behavior ; Stress, Psychological/metabolism
Czasopismo naukowe
Tytuł :
Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas.
Autorzy :
Issler O
Carter RN
Paul ED
Kelly PA
Olverman HJ
Neufeld-Cohen A
Kuperman Y
Lowry CA
Seckl JR
Chen A
Jamieson PM; Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. .
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Źródło :
Biology of mood & anxiety disorders [Biol Mood Anxiety Disord] 2014 Jan 21; Vol. 4 (1), pp. 1. Date of Electronic Publication: 2014 Jan 21.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Overexpression of corticotropin-releasing factor receptor type 2 in the bed nucleus of stria terminalis improves posttraumatic stress disorder-like symptoms in a model of incubation of fear.
Autorzy :
Elharrar E; The Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan; The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan.
Warhaftig G
Issler O
Sztainberg Y
Dikshtein Y
Zahut R
Redlus L
Chen A
Yadid G
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Źródło :
Biological psychiatry [Biol Psychiatry] 2013 Dec 01; Vol. 74 (11), pp. 827-36. Date of Electronic Publication: 2013 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fear/*physiology
Receptors, Corticotropin-Releasing Hormone/*metabolism
Septal Nuclei/*metabolism
Stress Disorders, Post-Traumatic/*therapy
Amygdala/metabolism ; Animals ; Behavioral Symptoms/psychology ; Behavioral Symptoms/therapy ; Disease Models, Animal ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone/genetics ; Stress Disorders, Post-Traumatic/psychology
Czasopismo naukowe
Tytuł :
Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge.
Autorzy :
Neufeld-Cohen A; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Kelly PA
Paul ED
Carter RN
Skinner E
Olverman HJ
Vaughan JM
Issler O
Kuperman Y
Lowry CA
Vale WW
Seckl JR
Chen A
Jamieson PM
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Źródło :
Biological psychiatry [Biol Psychiatry] 2012 Sep 15; Vol. 72 (6), pp. 437-47. Date of Electronic Publication: 2012 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anxiety/*metabolism
Hypothalamo-Hypophyseal System/*metabolism
Pituitary-Adrenal System/*metabolism
Receptor, Serotonin, 5-HT1A/*metabolism
Receptors, Corticotropin-Releasing Hormone/*metabolism
Serotonin 5-HT1 Receptor Agonists/*metabolism
Urocortins/*genetics
Analysis of Variance ; Animals ; Anxiety/genetics ; Brain/metabolism ; Chromatography, Liquid ; Corticosterone/metabolism ; Hydroxyindoleacetic Acid/analysis ; In Situ Hybridization ; Mice ; Mice, Transgenic ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction ; Receptor, Serotonin, 5-HT1A/genetics ; Receptors, Corticotropin-Releasing Hormone/genetics ; Serotonin/analysis ; Stress, Physiological ; Stress, Psychological ; Urocortins/metabolism
Czasopismo naukowe

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