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Tytuł :
Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression.
Autorzy :
Issler O; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
van der Zee YY; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, 6229 ER, Maastricht, the Netherlands.
Ramakrishnan A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wang J; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Tan C; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Loh YE; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Purushothaman I; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Walker DM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lorsch ZS; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hamilton PJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Peña CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Flaherty E; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hartley BJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Torres-Berrío A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Parise EM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kronman H; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Duffy JE; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Estill MS; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Calipari ES; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Labonté B; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Neve RL; Gene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA 02139, USA.
Tamminga CA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Brennand KJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Shen L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nestler EJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Jun 17; Vol. 106 (6), pp. 912-926.e5. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Resilience, Psychological*
Depressive Disorder, Major/*genetics
Prefrontal Cortex/*metabolism
RNA, Long Noncoding/*genetics
Stress, Psychological/*genetics
Adult ; Aged ; Aged, 80 and over ; Animals ; Behavior, Animal ; Depression/genetics ; Depression/metabolism ; Depressive Disorder, Major/metabolism ; Down-Regulation ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Neurons/metabolism ; RNA, Long Noncoding/metabolism ; RNA-Seq ; Sex Factors ; Stress, Psychological/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Unraveling the epigenetic landscape of depression: focus on early life stress
.
Autorzy :
Torres-Berrío A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
Issler O; Author affiliations: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
Parise EM; Author affiliations: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
Nestler EJ; Author affiliations: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
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Źródło :
Dialogues in clinical neuroscience [Dialogues Clin Neurosci] 2019 Dec; Vol. 21 (4), pp. 341-357.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Depression/*genetics
Depressive Disorder/*genetics
Genetic Predisposition to Disease/*genetics
Stress, Psychological/*genetics
Animals ; DNA Methylation/genetics ; Depression/drug therapy ; Depressive Disorder/drug therapy ; Epigenomics/methods ; Humans
Czasopismo naukowe
Tytuł :
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.
Autorzy :
Lorsch ZS; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hamilton PJ; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ramakrishnan A; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Parise EM; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Salery M; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wright WJ; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Lepack AE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mews P; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Issler O; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
McKenzie A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhou X; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Parise LF; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pirpinias ST; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ortiz Torres I; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kronman HG; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Montgomery SE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Loh YE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Labonté B; Department of Neuroscience and Psychiatry, Laval University, Québec City, Québec, Canada.
Conkey A; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Symonds AE; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neve RL; Gene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA, USA.
Turecki G; Department of Psychiatry, McGill University, Montréal, Québec, Canada.; McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Québec, Canada.
Maze I; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shen L; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bagot RC; Department of Psychiatry, McGill University, Montréal, Québec, Canada.; Department of Psychology, McGill University, Montréal, Québec, Canada.; Ludmer Centre for Neuroinformatics and Mental Health, Montréal, Québec, Canada.
Nestler EJ; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2019 Sep; Vol. 22 (9), pp. 1413-1423. Date of Electronic Publication: 2019 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptation, Psychological/*physiology
Stress, Psychological/*genetics
Zinc Fingers/*genetics
Animals ; Gene Regulatory Networks/genetics ; Mice ; Mice, Inbred C57BL ; Prefrontal Cortex/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Gadd45b mediates depressive-like role through DNA demethylation.
Autorzy :
Labonté B; CERVO Brain Research Centre, Department of Neuroscience and Psychiatry, Faculty of Medicine, Laval University, Québec, Canada.
Jeong YH; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41068, Korea.
Parise E; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Issler O; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Fatma M; CERVO Brain Research Centre, Department of Neuroscience and Psychiatry, Faculty of Medicine, Laval University, Québec, Canada.
Engmann O; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Cho KA; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41068, Korea.; Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Neve R; Viral Gene Transfer Core, McGovern Institute for Brain Research, MIT, Cambridge, MA, 02139, USA.
Nestler EJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Koo JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41068, Korea. .
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Źródło :
Scientific reports [Sci Rep] 2019 Mar 15; Vol. 9 (1), pp. 4615. Date of Electronic Publication: 2019 Mar 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Differentiation/*metabolism
DNA Demethylation/*drug effects
Depression/*metabolism
Animals ; Brain-Derived Neurotrophic Factor/metabolism ; DNA/metabolism ; Dopamine/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Nucleus Accumbens/metabolism ; Social Behavior ; Stress, Psychological/physiopathology ; Ventral Tegmental Area/metabolism
Czasopismo naukowe
Tytuł :
17. Lifelong Transcriptional, Epigenetic, and Neurophysiological Consequences of Early Life Stress in Mouse Brain Reward Circuitry.
Autorzy :
Pena, Catherine (AUTHOR)
Kronman, Hope (AUTHOR)
Friedman, Allyson (AUTHOR)
Walker, Deena (AUTHOR)
Cates, Hannah (AUTHOR)
Issler, Orna (AUTHOR)
Loh, Yong-Hwee E. (AUTHOR)
Bagot, Rosemary (AUTHOR)
Ramakrishnan, Aarthi (AUTHOR)
Purushothaman, Immanuel (AUTHOR)
Zhu, Yingbo (AUTHOR)
Neve, Rachael (AUTHOR)
Shen, Li (AUTHOR)
Nestler, Eric (AUTHOR)
Han, Ming-Hu (AUTHOR)
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Źródło :
Biological Psychiatry. 2018 Supplement, Vol. 83, pS7-S7. 1p.
Czasopismo naukowe
Tytuł :
86. Role of the Epigenetic Agent Acetyl-L-Carnitine as Gating Biomarker in Depression and Influences of Childhood Trauma.
Autorzy :
Nasca, Carla (AUTHOR)
Bigio, Betty (AUTHOR)
Lee, Francis (AUTHOR)
Zelli, Danielle (AUTHOR)
Young, Sarah (AUTHOR)
Lau, Timothy (AUTHOR)
Issler, Orna (AUTHOR)
Menard, Caroline (AUTHOR)
Murrough, James (AUTHOR)
Kocsis, James (AUTHOR)
Russo, Scott (AUTHOR)
Nestler, Eric (AUTHOR)
Rasgon, Natalie (AUTHOR)
McEwen, Bruce (AUTHOR)
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Źródło :
Biological Psychiatry. 2018 Supplement, Vol. 83, pS35-S36. 2p.
Czasopismo naukowe
Tytuł :
O41. CREB-Zfp189 Interactions Regulate a Resilient-Specific Transcriptional Network in Animal Models of Depression.
Autorzy :
Lorsch, Zachary (AUTHOR)
Hamilton, Peter (AUTHOR)
Lepack, Ashley (AUTHOR)
Mews, Philipp (AUTHOR)
Parise, Eric (AUTHOR)
Alcantara, Lyonna (AUTHOR)
Issler, Orna (AUTHOR)
Ramakrishnan, Aarthi (AUTHOR)
Purushothaman, Immanuel (AUTHOR)
Loh, Yong-Hwee E. (AUTHOR)
McKenzie, Andrew (AUTHOR)
Wang, Minghui (AUTHOR)
Maze, Ian (AUTHOR)
Zhang, Bin (AUTHOR)
Shen, Li (AUTHOR)
Bagot, Rosemary (AUTHOR)
Nestler, Eric (AUTHOR)
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Źródło :
Biological Psychiatry. 2018 Supplement, Vol. 83, pS125-S125. 1p.
Czasopismo naukowe
Tytuł :
Corrigendum: Sex-specific transcriptional signatures in human depression.
Autorzy :
Labonté B
Engmann O
Purushothaman I
Menard C
Wang J
Tan C
Scarpa JR
Moy G
Loh YE
Cahill M
Lorsch ZS
Hamilton PJ
Calipari ES
Hodes GE
Issler O
Kronman H
Pfau M
Obradovic ALJ
Dong Y
Neve RL
Russo S
Kasarskis A
Tamminga C
Mechawar N
Turecki G
Zhang B
Shen L
Nestler EJ
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Źródło :
Nature medicine [Nat Med] 2018 Apr 10; Vol. 24 (4), pp. 525.
Typ publikacji :
Published Erratum
Tytuł :
Estrogen receptor α drives pro-resilient transcription in mouse models of depression.
Autorzy :
Lorsch ZS; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Loh YE; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Purushothaman I; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Walker DM; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Parise EM; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Salery M; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Cahill ME; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Hodes GE; School of Neuroscience, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Blacksburg, VA, 24061, USA.
Pfau ML; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Kronman H; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Hamilton PJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Issler O; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Labonté B; Department of Neuroscience and Psychiatry, Faculty of Medicine, Laval University, 2601 Chemin de la Canardière Québec, QC, G1J 2G3, Canada.
Symonds AE; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Zucker M; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Zhang TY; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Institute, Sackler Program for Epigenetics and Psychobiology, Departments of Psychiatry and Neurology and Neurosurgery, McGill University, 6875 Boulevard Lasalle, Montréal, QC, H4H 1R3, Canada.
Meaney MJ; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Institute, Sackler Program for Epigenetics and Psychobiology, Departments of Psychiatry and Neurology and Neurosurgery, McGill University, 6875 Boulevard Lasalle, Montréal, QC, H4H 1R3, Canada.
Russo SJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Shen L; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Bagot RC; Departments of Psychology & Psychiatry, Ludmer Centre for Neuroinformatics and Mental Health, McGill University, 1205 Avenue Dr Penfield, Montréal, QC, H3A 1B1, Canada.
Nestler EJ; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA. .
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Źródło :
Nature communications [Nat Commun] 2018 Mar 16; Vol. 9 (1), pp. 1116. Date of Electronic Publication: 2018 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptation, Psychological/*physiology
Behavior, Animal/*physiology
Depression/*physiopathology
Estrogen Receptor alpha/*metabolism
Nucleus Accumbens/*metabolism
Stress, Psychological/*physiopathology
Animals ; Estrogen Receptor alpha/genetics ; Female ; Gene Expression Profiling ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Sex Factors ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.
Autorzy :
Engmann O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Labonté B; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Mitchell A; Departments of Psychiatry and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Bashtrykov P; Institute of Biochemistry, Stuttgart University, Stuttgart, Germany.
Calipari ES; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Rosenbluh C; Departments of Developmental and Regenerative Biology and of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Loh YE; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Walker DM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Burek D; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Hamilton PJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Neve RL; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Turecki G; Douglas Mental Health University Institute, Montreal, Quebec, Canada.
Hurd Y; Departments of Psychiatry and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Chess A; Departments of Developmental and Regenerative Biology and of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Shen L; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Mansuy I; University of Zurich/Eidgenössische Technische Hochschule Zurich Brain Research Institute, Zurich, Switzerland.
Jeltsch A; Institute of Biochemistry, Stuttgart University, Stuttgart, Germany.
Akbarian S; Departments of Psychiatry and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: .
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Źródło :
Biological psychiatry [Biol Psychiatry] 2017 Dec 01; Vol. 82 (11), pp. 794-805. Date of Electronic Publication: 2017 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatin/*drug effects
Cocaine/*administration & dosage
Dopamine Uptake Inhibitors/*administration & dosage
Gene Expression Regulation/*drug effects
Nuclear Proteins/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Cell Line, Tumor ; Cohort Studies ; Conditioning, Operant/drug effects ; Cytoskeletal Proteins ; DNA Methylation/drug effects ; Gene Expression Regulation/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Models, Molecular ; Molecular Conformation ; Neuroblastoma/pathology ; Nuclear Proteins/genetics ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/genetics ; Receptors, Dopamine D2/metabolism ; Transcription Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Sex-specific transcriptional signatures in human depression.
Autorzy :
Labonté B; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Engmann O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Purushothaman I; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Menard C; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Wang J; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tan C; Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Scarpa JR; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Moy G; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Loh YE; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Cahill M; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lorsch ZS; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hamilton PJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Calipari ES; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hodes GE; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kronman H; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Pfau M; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Obradovic ALJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Neve RL; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Russo S; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kazarskis A; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Tamminga C; Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mechawar N; Department of Psychiatry, McGill University, Montreal, Québec, Canada.; McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Turecki G; Department of Psychiatry, McGill University, Montreal, Québec, Canada.; McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Zhang B; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Shen L; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
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Źródło :
Nature medicine [Nat Med] 2017 Sep; Vol. 23 (9), pp. 1102-1111. Date of Electronic Publication: 2017 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptome*
Brain/*metabolism
Depressive Disorder, Major/*genetics
Stress, Psychological/*genetics
Adult ; Aged ; Animals ; Blotting, Western ; Case-Control Studies ; Cerebral Cortex/metabolism ; Disease Models, Animal ; Down-Regulation ; Female ; Hippocampus/metabolism ; Humans ; Immunohistochemistry ; Male ; Mice ; Middle Aged ; Nucleus Accumbens/metabolism ; Patch-Clamp Techniques ; Prefrontal Cortex/metabolism ; Pyramidal Cells/metabolism ; Sequence Analysis, RNA ; Sex Characteristics ; Sex Factors
Czasopismo naukowe

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