Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge
Overexpression of Corticotropin-Releasing Factor Receptor Type 2 in the Bed Nucleus of Stria Terminalis Improves Posttraumatic Stress Disorder-like Symptoms in a Model of Incubation of Fear
Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas.
MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity.
Autorzy :
Issler O; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel; Department of Stress Neurobiology and Neurogenetics, Max-Planck Institute of Psychiatry, 80804 Munich, Germany. Haramati S; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. Paul ED; Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA. Maeno H; Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA. Navon I; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. Zwang R; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. Gil S; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. Mayberg HS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. Dunlop BW; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. Menke A; Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, 80804 Munich, Germany. Awatramani R; Department of Neurology and Center for Genetic Medicine, Northwestern University Feinberg Medical School, Chicago, IL 60611, USA. Binder EB; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, 80804 Munich, Germany. Deneris ES; Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA. Lowry CA; Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA. Chen A; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel; Department of Stress Neurobiology and Neurogenetics, Max-Planck Institute of Psychiatry, 80804 Munich, Germany. Electronic address: .
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Źródło :
Neuron [Neuron] 2014 Jul 16; Vol. 83 (2), pp. 344-360. Date of Electronic Publication: 2014 Jun 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Bagot RC; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Cates HM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Purushothaman I; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Lorsch ZS; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Walker DM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Wang J; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Huang X; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Schlüter OM; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Maze I; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Peña CJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Heller EA; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Wang M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Song WM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Stein JL; Department of Genetics and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Liu X; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Doyle MA; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Scobie KN; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Sun HS; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Neve RL; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Geschwind D; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Shen L; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: . Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: . Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2016 Jun 01; Vol. 90 (5), pp. 969-83. Date of Electronic Publication: 2016 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine.
Autorzy :
Kiraly DD; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Walker DM; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Calipari ES; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Labonte B; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Issler O; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Pena CJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Ribeiro EA; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Russo SJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Nestler EJ; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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Źródło :
Scientific reports [Sci Rep] 2016 Oct 18; Vol. 6, pp. 35455. Date of Electronic Publication: 2016 Oct 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.
Autorzy :
Lepack AE; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Bagot RC; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Peña CJ; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Loh YE; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Farrelly LA; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Lu Y; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Powell SK; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Lorsch ZS; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Issler O; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Cates HM; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Tamminga CA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75235. Molina H; The Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY 10065. Shen L; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Nestler EJ; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Department of Pharmacological Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY 10029. Allis CD; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065. Maze I; Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029; .; Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Department of Pharmacological Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029.; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065.
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