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    Wyświetlanie 1-12 z 12
    Tytuł:
    KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily.
    Autorzy:
    Pons T; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro, 3, 28029, Madrid, Spain.
    Vazquez M; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro, 3, 28029, Madrid, Spain.
    Matey-Hernandez ML; Center for Biological Sequence Analysis (CBS), Systems Biology Department, Technical University of Denmark (DTU), Kemitorvet, Building 208, 2800 Kgs., Lyngby, Denmark.
    Brunak S; Center for Biological Sequence Analysis (CBS), Systems Biology Department, Technical University of Denmark (DTU), Kemitorvet, Building 208, 2800 Kgs., Lyngby, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3A, 2200, Copenhagen, Denmark.
    Valencia A; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro, 3, 28029, Madrid, Spain.
    Izarzugaza JM; Center for Biological Sequence Analysis (CBS), Systems Biology Department, Technical University of Denmark (DTU), Kemitorvet, Building 208, 2800 Kgs., Lyngby, Denmark. .
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    Źródło:
    BMC genomics [BMC Genomics] 2016 Jun 23; Vol. 17 Suppl 2, pp. 396. Date of Electronic Publication: 2016 Jun 23.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Mutation*
    Computational Biology/*methods
    Protein Kinases/*genetics
    Databases, Protein ; Decision Trees ; Genetic Variation ; Humans ; Software
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Identification of Known and Novel Recurrent Viral Sequences in Data from Multiple Patients and Multiple Cancers.
    Autorzy:
    Friis-Nielsen J; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. .
    Kjartansdóttir KR; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Mollerup S; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Asplund M; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Mourier T; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Jensen RH; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Hansen TA; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Rey-Iglesia A; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Richter SR; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Nielsen IB; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Alquezar-Planas DE; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Olsen PV; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Vinner L; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Fridholm H; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Nielsen LP; Department of Autoimmunology and Biomarkers, Statens Serum Institut, DK-2300 Copenhagen S, Denmark. .
    Willerslev E; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Sicheritz-Pontén T; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. .
    Lund O; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. .
    Hansen AJ; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen, Denmark. .
    Izarzugaza JM; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. .
    Brunak S; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. .; NNF Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark. .
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    Źródło:
    Viruses [Viruses] 2016 Feb 19; Vol. 8 (2). Date of Electronic Publication: 2016 Feb 19.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Neoplasms/*virology
    Viruses/*genetics
    Viruses/*isolation & purification
    Computational Biology ; Conserved Sequence ; High-Throughput Nucleotide Sequencing ; Humans ; RNA, Viral/genetics ; Viruses/classification
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Investigation of Human Cancers for Retrovirus by Low-Stringency Target Enrichment and High-Throughput Sequencing.
    Autorzy:
    Vinner L; Centre for GeoGenetics Natural History Museum, University of Copenhagen Østervoldgade 5-7, 1350 Copenhagen K, Denmark.
    Mourier T; Centre for GeoGenetics Natural History Museum, University of Copenhagen Østervoldgade 5-7, 1350 Copenhagen K, Denmark.
    Friis-Nielsen J; Center for Biological Sequence Analysis. Department of Systems Biology, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark.
    Gniadecki R; Department of Dermatology D92, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 N, Copenhagen, Denmark.
    Dybkaer K; Department of Heamatology Aalborg University Hospital, Sdr. Skovvej 15, 9000 Aalborg, Denmark.
    Rosenberg J; Department of Surgery Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
    Langhoff JL; Department of Pathology Herlev hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
    Cruz DF; Center for Biological Sequence Analysis. Department of Systems Biology, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark.
    Fonager J; Department of Microbiological Diagnostics and Virology, Statens Serum Institut Artillerivej 5, 2300 Copenhagen S, Denmark.
    Izarzugaza JM; Center for Biological Sequence Analysis. Department of Systems Biology, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark.
    Gupta R; Center for Biological Sequence Analysis. Department of Systems Biology, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark.
    Sicheritz-Ponten T; Center for Biological Sequence Analysis. Department of Systems Biology, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark.
    Brunak S; Center for Biological Sequence Analysis. Department of Systems Biology, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark.
    Willerslev E; Centre for GeoGenetics Natural History Museum, University of Copenhagen Østervoldgade 5-7, 1350 Copenhagen K, Denmark.
    Nielsen LP; 1] Department of Epidemiology Research, Statens Serum Institut Artillerivej 5, 2300 Copenhagen S, Denmark [2] Health Sciences and Technology Aalborg University Fredrik Bajers Vej 7D2, 9220 Aalborg, Denmark.
    Hansen AJ; Centre for GeoGenetics Natural History Museum, University of Copenhagen Østervoldgade 5-7, 1350 Copenhagen K, Denmark.
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    Źródło:
    Scientific reports [Sci Rep] 2015 Aug 19; Vol. 5, pp. 13201. Date of Electronic Publication: 2015 Aug 19.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    High-Throughput Nucleotide Sequencing/*methods
    Neoplasms/*virology
    Retroviridae/*genetics
    Animals ; Base Sequence ; DNA Probes/metabolism ; DNA, Viral/genetics ; Gene Library ; Genome, Human ; HEK293 Cells ; HIV-1/genetics ; Humans ; Proviruses/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction ; Sus scrofa
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    wKinMut: an integrated tool for the analysis and interpretation of mutations in human protein kinases.
    Autorzy:
    Izarzugaza JM; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernandez Almagro, 3, E-28029 Madrid, Spain. .
    Vazquez M
    del Pozo A
    Valencia A
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2013 Nov 29; Vol. 14, pp. 345. Date of Electronic Publication: 2013 Nov 29.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Computational Biology/*methods
    Leukemia, Lymphocytic, Chronic, B-Cell/*enzymology
    Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
    Mutation/*genetics
    Protein Kinases/*chemistry
    Databases, Protein/trends ; ErbB Receptors/genetics ; Humans ; Information Storage and Retrieval/methods ; Leukemia, Lymphocytic, Chronic, B-Cell/etiology ; Phenotype ; Predictive Value of Tests ; Protein Kinases/classification ; Protein Kinases/genetics ; Protein Stability
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.
    Autorzy:
    Birkbak NJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America ; Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
    Kochupurakkal B
    Izarzugaza JM
    Eklund AC
    Li Y
    Liu J
    Szallasi Z
    Matulonis UA
    Richardson AL
    Iglehart JD
    Wang ZC
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    Źródło:
    PloS one [PLoS One] 2013 Nov 12; Vol. 8 (11), pp. e80023. Date of Electronic Publication: 2013 Nov 12 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genes, BRCA1*
    Genes, BRCA2*
    Mutation*
    Ovarian Neoplasms/*genetics
    Age Factors ; Chromosome Aberrations ; Drug Resistance, Neoplasm/genetics ; Exome ; Female ; Genome-Wide Association Study ; Germ-Line Mutation ; Humans ; Loss of Heterozygosity ; Neoplasm Grading ; Neoplasm Staging ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Prognosis ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Prediction of disease causing non-synonymous SNPs by the Artificial Neural Network Predictor NetDiseaseSNP.
    Autorzy:
    Johansen MB; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
    Izarzugaza JM
    Brunak S
    Petersen TN
    Gupta R
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    Źródło:
    PloS one [PLoS One] 2013 Jul 25; Vol. 8 (7), pp. e68370. Date of Electronic Publication: 2013 Jul 25 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Predisposition to Disease*
    Mutation*
    Polymorphism, Single Nucleotide*
    Computational Biology/*methods
    Neoplasms/*diagnosis
    Neoplasms/*genetics
    Algorithms ; Base Sequence ; Conserved Sequence ; Female ; Humans ; Male ; Molecular Sequence Data ; Neural Networks, Computer ; Sequence Alignment
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Prioritization of pathogenic mutations in the protein kinase superfamily.
    Autorzy:
    Izarzugaza JM; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. />del Pozo A
    Vazquez M
    Valencia A
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    Źródło:
    BMC genomics [BMC Genomics] 2012 Jun 18; Vol. 13 Suppl 4, pp. S3. Date of Electronic Publication: 2012 Jun 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Protein Kinases/*genetics
    Databases, Protein ; Humans ; Mutation ; Neoplasms/genetics ; Support Vector Machine
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Characterization of pathogenic germline mutations in human protein kinases.
    Autorzy:
    Izarzugaza JM; Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernandez Almagro 3, E28029 Madrid, Spain.
    Hopcroft LE
    Baresic A
    Orengo CA
    Martin AC
    Valencia A
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2011; Vol. 12 Suppl 4, pp. S1. Date of Electronic Publication: 2011 Jul 05.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Germ-Line Mutation*
    Point Mutation*
    Protein Kinases/*genetics
    Humans ; Models, Molecular ; Neoplasms/genetics ; Nuclear Receptor Subfamily 4, Group A, Member 2 ; Protein Binding ; Protein Kinases/chemistry ; Protein Kinases/metabolism ; Protein Structure, Tertiary ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Extraction of human kinase mutations from literature, databases and genotyping studies.
    Autorzy:
    Krallinger M; Spanish National Cancer Research Centre, Madrid, Spain. />Izarzugaza JM
    Rodriguez-Penagos C
    Valencia A
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2009 Aug 27; Vol. 10 Suppl 8, pp. S1. Date of Electronic Publication: 2009 Aug 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Mutation*
    Information Storage and Retrieval/*methods
    Protein Kinases/*genetics
    Databases, Genetic ; ErbB Receptors/genetics ; Genomics ; Genotype ; Humans ; Periodicals as Topic ; Reproducibility of Results ; Sequence Analysis, DNA
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D.
    Autorzy:
    Izarzugaza JM; Institute of Structural and Molecular Biology, University College London, UK. />Baresic A
    McMillan LE
    Yeats C
    Clegg AB
    Orengo CA
    Martin AC
    Valencia A
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2009 Aug 27; Vol. 10 Suppl 8, pp. S5. Date of Electronic Publication: 2009 Aug 27.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Amino Acid Substitution*
    Mutation*
    Information Storage and Retrieval/*methods
    Proteins/*genetics
    Databases, Protein ; Internet ; Models, Molecular ; Phenotype ; Proteins/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Enhancing the prediction of protein pairings between interacting families using orthology information.
    Autorzy:
    Izarzugaza JM; Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro, 3. 28029, Madrid,Spain. />Juan D
    Pons C
    Pazos F
    Valencia A
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2008 Jan 23; Vol. 9, pp. 35. Date of Electronic Publication: 2008 Jan 23.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Information Systems*/trends
    Databases, Protein/*classification
    Proteins/*classification
    Proteins/*genetics
    Forecasting ; Protein Binding/physiology ; Protein Interaction Mapping/classification ; Protein Interaction Mapping/methods ; Proteins/metabolism ; Sequence Alignment/methods ; Yeasts/genetics ; Yeasts/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-12 z 12

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