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Tytuł :
Interaction between non-coding RNAs and JNK in human disorders.
Autorzy :
Ghafouri-Fard S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abak A; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohaqiq M; School of Advancement, Centennial College, Ashtonbee Campus, Toronto, ON, Canada; Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Shoorei H; Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Taheri M; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111497. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
JNK Mitogen-Activated Protein Kinases/*metabolism
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
Signal Transduction/*physiology
Brain Injuries/genetics ; Brain Injuries/metabolism ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases/genetics ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; RNA, Long Noncoding/genetics
Czasopismo naukowe
Tytuł :
Commentary: Every detail counts-different c-Jun N-terminal kinase isoforms perform different functions.
Autorzy :
van Berkel V; Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine, Louisville, Ky. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2021 Aug; Vol. 162 (2), pp. e157-e158. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Editorial; Comment
MeSH Terms :
JNK Mitogen-Activated Protein Kinases*/metabolism
Signal Transduction*
Humans ; Phosphorylation ; Protein Isoforms
Opinia redakcyjna
Tytuł :
Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3.
Autorzy :
Li ZX; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China; Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, China; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Yang DJ; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China; Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, China.
Huo ZK; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China; Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, China.
Wen PH; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China.
Hu BW; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China.
Wang ZH; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China.
Guo WZ; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China; Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, China.
Zhang SJ; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan Medical Engineering and Technology Center of Organ Transplantation, Zhengzhou, Henan, China; Zhengzhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 07; Vol. 552, pp. 150-156. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Brain Death/*physiopathology
Caspase 3/*genetics
Chitinase-3-Like Protein 1/*genetics
Hepatocytes/*metabolism
JNK Mitogen-Activated Protein Kinases/*genetics
Receptor, PAR-2/*genetics
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Line, Tumor ; Cells, Cultured ; Chitin/pharmacology ; Chitinase-3-Like Protein 1/metabolism ; Gene Expression Regulation ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; RNA Interference ; Rats, Sprague-Dawley ; Receptor, PAR-2/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways.
Autorzy :
Yang L; Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Liu R; Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Fang Y; First Affilated Hospital of Gannan Medical University, Ganzhou 341000, China.
He J; Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 May; Vol. 94, pp. 107463. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Coumarins/*pharmacology
Furans/*pharmacology
JNK Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Lignans/*pharmacology
NF-kappa B/*antagonists & inhibitors
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Araliaceae ; Cell Line ; Cell Survival/drug effects ; Cytokines/metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase.
Autorzy :
Ge Y; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Ramirez DH; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Yang B; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
D'Souza AK; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Aonbangkhen C; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Wong S; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Woo CM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 May; Vol. 17 (5), pp. 593-600. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm/*metabolism
Histone Acetyltransferases/*metabolism
Hyaluronoglucosaminidase/*metabolism
JNK Mitogen-Activated Protein Kinases/*metabolism
Membrane Glycoproteins/*metabolism
Nuclear Pore Complex Proteins/*metabolism
Recombinant Fusion Proteins/*metabolism
Single-Domain Antibodies/*chemistry
Sp1 Transcription Factor/*metabolism
Transcription Factors/*metabolism
Antigens, Neoplasm/chemistry ; Antigens, Neoplasm/genetics ; Biological Assay ; Catalytic Domain ; Drug Delivery Systems/methods ; Gene Expression ; Glycosylation ; HEK293 Cells ; Histone Acetyltransferases/chemistry ; Histone Acetyltransferases/genetics ; Humans ; Hyaluronoglucosaminidase/chemistry ; Hyaluronoglucosaminidase/genetics ; Hydrolysis ; JNK Mitogen-Activated Protein Kinases/genetics ; Membrane Glycoproteins/genetics ; Nuclear Pore Complex Proteins/genetics ; Plasmids/chemistry ; Plasmids/metabolism ; Protein Binding ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Single-Domain Antibodies/metabolism ; Sp1 Transcription Factor/genetics ; Transcription Factors/genetics ; Transfection/methods
Czasopismo naukowe
Tytuł :
c-Jun N-terminal Kinase Mediates Ligand-independent p75 Signaling in Mesencephalic Cells Subjected to Oxidative Stress.
Autorzy :
Kraemer BR; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States. Electronic address: .
Clements RT; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Escobedo CM; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Nelson KS; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Waugh CD; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Elliott AS; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Hall WC; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
Schemanski MT; From the Department of Biological Sciences, Eastern Kentucky University, Richmond, KY 40475, United States.
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Źródło :
Neuroscience [Neuroscience] 2021 Jan 15; Vol. 453, pp. 222-236. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
JNK Mitogen-Activated Protein Kinases*/metabolism
Receptors, Nerve Growth Factor*/metabolism
Humans ; Ligands ; Mesencephalon/metabolism ; Oxidative Stress ; Receptor, Nerve Growth Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.
Autorzy :
Wu Q; College of Life Science, Yangtze University, Jingzhou, China.; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Wu W; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Jacevic V; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; National Poison Control Centre, Military Medical Academy, Belgrade, Serbia.; Medical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia.
Franca TCC; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Rio de Janeiro, Brazil.
Wang X; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 574-583.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
JNK Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Compare the Effects of Magnolol on Gastric Cancer Cells Through c-Jun N-Terminal Kinase Signaling Pathway and Gold Magnetic.
Autorzy :
Chen Y; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
He X; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
Feng D; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
Li S; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
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Źródło :
Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2021 Feb 01; Vol. 21 (2), pp. 943-948.
Typ publikacji :
Journal Article
MeSH Terms :
JNK Mitogen-Activated Protein Kinases*
Signal Transduction*
Stomach Neoplasms*/drug therapy
Biphenyl Compounds/*pharmacology
Lignans/*pharmacology
Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Gold ; Humans ; Magnetic Phenomena
Czasopismo naukowe
Tytuł :
JNK selective inhibitor, IQ-1S, protects the mice against lipopolysaccharides-induced sepsis.
Autorzy :
Nie Z; Department of Emergency, Xingtai People's Hospital of Hebei Province, No. 16 Hongxing Street, Xingtai 054000, Hebei, China. Electronic address: .
Xia X; Department of Cardiology CCU, Xingtai Third Hospital of Hebei Province, No. 108 Gangtie, North Street, Xingtai 054000, Hebei, China.
Zhao Y; The Second Affiliated Hospital of Xingtai Medical College, No. 618 Gangtie, North Street, Xingtai 054000, Hebei, China.
Zhang S; Department of Emergency, Xingtai People's Hospital of Hebei Province, No. 16 Hongxing Street, Xingtai 054000, Hebei, China.
Zhang Y; Department of Emergency, Xingtai People's Hospital of Hebei Province, No. 16 Hongxing Street, Xingtai 054000, Hebei, China.
Wang J; Department of Emergency, Xingtai People's Hospital of Hebei Province, No. 16 Hongxing Street, Xingtai 054000, Hebei, China.
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jan 15; Vol. 30, pp. 115945. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
JNK Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Lipopolysaccharides/*antagonists & inhibitors
Oximes/*pharmacology
Protective Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Quinoxalines/*pharmacology
Sepsis/*drug therapy
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Sepsis/chemically induced ; Sepsis/metabolism ; Signal Transduction/drug effects ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma.
Autorzy :
Huang G; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Su J; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhao W; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Deng Z; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Wang P; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Dong H; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhao H; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: .
Cai S; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jan 01; Vol. 336, pp. 57-67. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Bronchoconstriction*/drug effects
Anti-Asthmatic Agents/*pharmacology
Asthma/*enzymology
JNK Mitogen-Activated Protein Kinases/*metabolism
Lung/*enzymology
Pneumonia/*enzymology
Receptor for Advanced Glycation End Products/*metabolism
beta Catenin/*metabolism
Adult ; Aged ; Animals ; Asthma/chemically induced ; Asthma/physiopathology ; Asthma/prevention & control ; Case-Control Studies ; Cell Line ; Disease Models, Animal ; Female ; Humans ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Lung/drug effects ; Lung/physiopathology ; Male ; Mice, Inbred C57BL ; Middle Aged ; Phosphorylation ; Pneumonia/chemically induced ; Pneumonia/physiopathology ; Pneumonia/prevention & control ; Protein Kinase Inhibitors/pharmacology ; Receptor for Advanced Glycation End Products/antagonists & inhibitors ; Serum Albumin, Human ; Signal Transduction ; Toluene 2,4-Diisocyanate
Czasopismo naukowe
Tytuł :
Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain.
Autorzy :
Ullah R; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Ikram M; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Park TJ; Haemato-Oncology/Systems Medicine Group, Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences (MVLS), University of Glasgow, Glasgow G12OZD, UK.
Ahmad R; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Saeed K; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Alam SI; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Rehman IU; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Khan A; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Khan I; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Jo MG; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
Kim MO; Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 31; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*drug effects
Gene Expression Regulation, Enzymologic/*drug effects
Gliosis/*drug therapy
JNK Mitogen-Activated Protein Kinases/*metabolism
Lipopolysaccharides/*toxicity
Neuroprotective Agents/*pharmacology
Vanillic Acid/*pharmacology
Animals ; Brain/metabolism ; Brain/pathology ; Gliosis/chemically induced ; Gliosis/metabolism ; Gliosis/pathology ; JNK Mitogen-Activated Protein Kinases/genetics ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Wnt/PCP signalling cascade disruption by JNK inhibition as a potential mechanism underlying the teratogenic effects of potato glycoalkaloids.
Autorzy :
Cuschieri A; Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Imsida, MSD2080, Malta. .
Calleja-Agius J; Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Imsida, MSD2080, Malta.
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Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Nov; Vol. 47 (11), pp. 9235-9238. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Polarity/*drug effects
Epithelial Cells/*drug effects
JNK Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Neural Tube Defects/*diagnosis
Solanine/*toxicity
Wnt Signaling Pathway/*drug effects
Animals ; Cell Movement/drug effects ; Cell Polarity/physiology ; Epithelial Cells/physiology ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Models, Biological ; Neural Tube Defects/chemically induced ; Solanum tuberosum/chemistry ; Teratogenesis/drug effects ; Wnt Signaling Pathway/physiology
Czasopismo naukowe
Tytuł :
Major histocompatibility complexes are up-regulated in glomerular endothelial cells via activation of c-Jun N-terminal kinase in 5/6 nephrectomy mice.
Autorzy :
Zhu D; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Department of Urology, Zhongshan Hospital Fudan University, Shanghai, China.
Tang Q; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Department of Urology, Zhongshan Hospital Fudan University, Shanghai, China.
Yu B; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Institute of Clinical Science, Zhongshan Hospital Fudan University, Shanghai, China.
Meng M; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Institute of Clinical Science, Zhongshan Hospital Fudan University, Shanghai, China.
Liu W; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Institute of Clinical Science, Zhongshan Hospital Fudan University, Shanghai, China.
Li J; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Department of Urology, Zhongshan Hospital Fudan University, Shanghai, China.
Zhu T; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Department of Urology, Zhongshan Hospital Fudan University, Shanghai, China.
Vanhoutte PM; Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong.
Leung SWS; Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong.
Zhang Y; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Institute of Clinical Science, Zhongshan Hospital Fudan University, Shanghai, China.
Shi Y; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai, China.; Institute of Clinical Science, Zhongshan Hospital Fudan University, Shanghai, China.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2020 Nov; Vol. 177 (22), pp. 5131-5147. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
JNK Mitogen-Activated Protein Kinases*
Nuclear Proteins*
Animals ; Endothelial Cells ; Histocompatibility ; Interferon-gamma ; Major Histocompatibility Complex ; Mice ; Mice, Inbred BALB C ; Nephrectomy
Czasopismo naukowe
Tytuł :
Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats.
Autorzy :
Zhang H; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Wei M; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Sun Q; School of Resources and Environment, Northeast Agricultural University, Harbin, 150030, PR China.
Yang T; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Lu X; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Feng X; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Song M; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Cui L; College of Life Science, Northeast Agricultural University, Harbin, 150030, PR China.
Fan H; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Nov; Vol. 145, pp. 111688. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article
MeSH Terms :
Hippocampus/*drug effects
Hippocampus/*injuries
JNK Mitogen-Activated Protein Kinases/*metabolism
Learning/*drug effects
Lycopene/*administration & dosage
Memory/*drug effects
Reactive Oxygen Species/*metabolism
Animals ; Antioxidants/administration & dosage ; Apoptosis/drug effects ; Hippocampus/metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases/genetics ; Male ; Maze Learning ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Stress, Physiological/drug effects
Czasopismo naukowe
Tytuł :
JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia.
Autorzy :
Mulder SE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Dasgupta A; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
King RJ; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Abrego J; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Attri KS; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Murthy D; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Shukla SK; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: .
Singh PK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Oct 28; Vol. 491, pp. 70-77. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cachexia/*etiology
JNK Mitogen-Activated Protein Kinases/*physiology
MAP Kinase Signaling System/*physiology
Muscle Proteins/*metabolism
Muscle, Skeletal/*metabolism
Pancreatic Neoplasms/*complications
Animals ; Anthracenes/pharmacology ; Anthracenes/therapeutic use ; Cachexia/drug therapy ; Cachexia/metabolism ; Cell Line, Tumor ; Female ; Humans ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mice ; Muscle Fibers, Skeletal/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
JNK signalling regulates antioxidant responses in neurons.
Autorzy :
Ugbode C; Department of Biology, University of York, York, YO10 5DD, UK; York Biomedical Research Institute, University of York, York, YO10 5DD, UK.
Garnham N; Department of Biology, University of York, York, YO10 5DD, UK; York Biomedical Research Institute, University of York, York, YO10 5DD, UK.
Fort-Aznar L; Department of Biology, University of York, York, YO10 5DD, UK; York Biomedical Research Institute, University of York, York, YO10 5DD, UK.
Evans GJO; Department of Biology, University of York, York, YO10 5DD, UK; York Biomedical Research Institute, University of York, York, YO10 5DD, UK.
Chawla S; Department of Biology, University of York, York, YO10 5DD, UK; York Biomedical Research Institute, University of York, York, YO10 5DD, UK. Electronic address: .
Sweeney ST; Department of Biology, University of York, York, YO10 5DD, UK; York Biomedical Research Institute, University of York, York, YO10 5DD, UK. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2020 Oct; Vol. 37, pp. 101712. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants*
JNK Mitogen-Activated Protein Kinases*/genetics
JNK Mitogen-Activated Protein Kinases*/metabolism
Animals ; MAP Kinase Signaling System ; Neurons/metabolism ; Oxidative Stress ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Endothelin-1 stimulates preadipocyte growth via the PKC, STAT3, AMPK, c-JUN, ERK, sphingosine kinase, and sphingomyelinase pathways.
Autorzy :
Siao AC; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
Lin YY; Department of Life Sciences, National Central University, Taoyuan, Taiwan.; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.; National Defense Medical Center, Taipei, Taiwan.
Shih LJ; National Defense Medical Center, Taipei, Taiwan.; Medical Laboratory, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Tsuei YW; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Chuu CP; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
Kuo YC; Division of Gastroenterology, Landseed Hospital, Taoyuan, Taiwan.
Kao YH; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Nov 01; Vol. 319 (5), pp. C839-C857. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*drug effects
Endothelin-1/*pharmacology
JNK Mitogen-Activated Protein Kinases/*genetics
Protein Kinase C/*genetics
STAT3 Transcription Factor/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/metabolism ; Animals ; Butadienes/pharmacology ; Cell Differentiation ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Endothelin Receptor Antagonists/pharmacology ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation ; Imidazoles/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Nitriles/pharmacology ; Oligopeptides/pharmacology ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Piperidines/pharmacology ; Protein Kinase C/metabolism ; Pyridines/pharmacology ; Receptors, Endothelin/genetics ; Receptors, Endothelin/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Long-term instillation to four natural representative chrysotile of China induce the inactivation of P53 and P16 and the activation of C-JUN and C-FOS in the lung tissues of Wistar rats.
Autorzy :
Luo Y; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Deng J; Medical Laboratory, Sichuan Mianyang 404 Hospital, No.2 Affiliated Hospital of North Sichuan Medical College, Mianyang 621000, Sichuan Province, China.
Cui Y; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Li T; Key Laboratory of Ministry of Education, Myocardial electrical laboratory, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Bai J; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Huang L; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Sun Y; School of Earth Science and Environmental Engineering, Southwest Jiaotong University, Chengdu, 611756, Sichuan, China.
Dong F; Key Laboratory of Solid Waste Treatment and the Resource Recycle, Southwest University of Science and Technology, Mianyang, 621010, Sichuan, China. Electronic address: .
Zhang Q; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 15; Vol. 333, pp. 140-149. Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Asbestos, Serpentine/*toxicity
Cyclin-Dependent Kinase Inhibitor p16/*metabolism
Environmental Pollutants/*toxicity
JNK Mitogen-Activated Protein Kinases/*metabolism
Lung/*drug effects
Proto-Oncogene Proteins c-fos/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Asbestos, Serpentine/chemistry ; Bronchoalveolar Lavage Fluid/cytology ; China ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cytokines/metabolism ; Environmental Pollutants/chemistry ; Gene Expression/drug effects ; Inhalation Exposure/adverse effects ; JNK Mitogen-Activated Protein Kinases/genetics ; Leukocyte Count ; Leukocytes/cytology ; Leukocytes/drug effects ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Male ; Mineral Fibers/toxicity ; Proto-Oncogene Proteins c-fos/genetics ; Rats, Wistar ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
The splice 1 variant of HTLV-1 bZIP factor stabilizes c-Jun.
Autorzy :
Polakowski N; ECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA. Electronic address: .
Pearce M; ECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Kuguyo O; ECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Boateng G; ECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Hoang K; ECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Lemasson I; ECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA. Electronic address: .
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Źródło :
Virology [Virology] 2020 Oct; Vol. 549, pp. 51-58. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alternative Splicing*
Basic-Leucine Zipper Transcription Factors/*genetics
Host-Pathogen Interactions/*genetics
Human T-lymphotropic virus 1/*genetics
JNK Mitogen-Activated Protein Kinases/*genetics
Retroviridae Proteins/*genetics
Basic-Leucine Zipper Transcription Factors/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; Cullin Proteins/genetics ; Cullin Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; HEK293 Cells ; HeLa Cells ; Human T-lymphotropic virus 1/metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Jurkat Cells ; Primary Cell Culture ; Protein Binding ; Protein Stability ; Proteolysis ; Retroviridae Proteins/metabolism ; Signal Transduction ; T-Lymphocytes/metabolism ; T-Lymphocytes/virology ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity.
Autorzy :
Lin YH; Department of Pharmacology, China Medical University, Taichung 40402, Taiwan, ROC; School of Pharmacy, College of Pharmacy, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan, ROC.
Hsiao YH; Department of Pharmacology, China Medical University, Taichung 40402, Taiwan, ROC.
Ng KL; Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan, ROC; Department of Medical Research, China Medical University Hospital, China Medical University, 40402, Taiwan, ROC.
Kuo YH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan, ROC; Department of Biotechnology, Asia University, Taichung 40402, Taiwan, ROC; Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan, ROC.
Lim YP; School of Pharmacy, College of Pharmacy, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan, ROC.
Hsieh WT; Department of Pharmacology, China Medical University, Taichung 40402, Taiwan, ROC; Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan, ROC; Drug Development Center, China Medical University, Taichung 40402, Taiwan, ROC. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Sep 01; Vol. 402, pp. 115115. Date of Electronic Publication: 2020 Jul 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*drug therapy
Inflammation/*metabolism
JNK Mitogen-Activated Protein Kinases/*metabolism
Transcription Factor AP-1/*metabolism
Withanolides/*pharmacology
Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Carrageenan/toxicity ; Cell Survival/drug effects ; Down-Regulation/drug effects ; Gene Expression Regulation/drug effects ; I-kappa B Proteins/genetics ; I-kappa B Proteins/metabolism ; JNK Mitogen-Activated Protein Kinases/genetics ; Male ; Malondialdehyde ; Mice ; Mice, Inbred ICR ; Molecular Structure ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Physalis/chemistry ; RAW 264.7 Cells ; Random Allocation ; Transcription Factor AP-1/genetics ; Withanolides/chemistry
Czasopismo naukowe

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