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Wyświetlanie 1-20 z 20
Tytuł :
Summary of major conclusions from the 5th IWGT, Basel, Switzerland, 17-19 August 2009.
Autorzy :
Kirkland DJ; Kirkland Consulting, PO Box 79, Tadcaster LS24 0AS, UK. />Hayashi M
Jacobson-Kram D
Kasper P
Gollapudi B
Müller L
Uno Y
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Źródło :
Mutation research [Mutat Res] 2011 Aug 16; Vol. 723 (2), pp. 73-6. Date of Electronic Publication: 2011 Mar 16.
Typ publikacji :
Introductory Journal Article
MeSH Terms :
Mutagenicity Tests/*methods
Mutagenicity Tests/*trends
Animals ; Humans
Czasopismo naukowe
Tytuł :
Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative.
Autorzy :
Thybaud V; Drug Safety Evaluation, sanofi-aventis, 94400 Vitry sur Seine, France.
Aardema M
Casciano D
Dellarco V
Embry MR
Gollapudi BB
Hayashi M
Holsapple MP
Jacobson-Kram D
Kasper P
MacGregor JT
Rees R
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Źródło :
Mutation research [Mutat Res] 2007 Oct 04; Vol. 633 (2), pp. 67-79. Date of Electronic Publication: 2007 May 24.
Typ publikacji :
Congress
MeSH Terms :
Data Interpretation, Statistical*
Mutagenicity Tests*/standards
Animals ; Dose-Response Relationship, Drug ; Follow-Up Studies ; Humans ; Mutagens/pharmacokinetics ; Mutagens/toxicity ; Reproducibility of Results ; Risk Assessment
Tytuł :
Summary of major conclusions from the 4th IWGT, San Francisco, 9-10 September, 2005.
Autorzy :
Kirkland DJ; Covance Laboratories Ltd., Otley Road, Harrogate, HG3 1PY, UK. />Hayashi M
Jacobson-Kram D
Kasper P
MacGregor JT
Müller L
Uno Y
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Źródło :
Mutation research [Mutat Res] 2007 Feb 03; Vol. 627 (1), pp. 5-9. Date of Electronic Publication: 2006 Nov 29.
Typ publikacji :
Congress
MeSH Terms :
Mutagenicity Tests/*methods
Animals ; Bone Marrow Cells ; Carcinogens/classification ; Carcinogens/toxicity ; Comet Assay/methods ; Lymphoma/genetics ; Micronucleus Tests/methods ; Mutagens/toxicity ; Mutation ; Risk Assessment ; Rodentia ; Thymidine Kinase/genetics
Tytuł :
The International Workshops on Genotoxicity Testing (IWGT): history and achievements.
Autorzy :
Kirkland DJ
Hayashi M
Jacobson-Kram D
Kasper P
MacGregor JT
Müller L
Uno Y
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Źródło :
Mutation research [Mutat Res] 2007 Feb 03; Vol. 627 (1), pp. 1-4. Date of Electronic Publication: 2006 Nov 28.
Typ publikacji :
Editorial
MeSH Terms :
Mutagenicity Tests/*methods
Animals ; Congresses as Topic ; International Cooperation ; Mice ; Mutagenicity Tests/standards
Opinia redakcyjna
Tytuł :
Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.
Autorzy :
Thybaud V; Drug Safety Evaluation, Sanofi-aventis, 94400 Vitry sur Seine, France. />Aardema M
Clements J
Dearfield K
Galloway S
Hayashi M
Jacobson-Kram D
Kirkland D
MacGregor JT
Marzin D
Ohyama W
Schuler M
Suzuki H
Zeiger E
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Corporate Authors :
Expert Working Group on Hazard Identification and Risk Assessment in Relation to In Vitro Testing
Źródło :
Mutation research [Mutat Res] 2007 Feb 03; Vol. 627 (1), pp. 41-58. Date of Electronic Publication: 2006 Nov 27.
Typ publikacji :
Journal Article
MeSH Terms :
Risk Assessment*
Mutagenicity Tests/*methods
Mutagenicity Tests/*trends
Animals ; Chromosome Aberrations ; Cytogenetic Analysis ; DNA/drug effects ; Dose-Response Relationship, Drug ; Follow-Up Studies ; Humans ; Mutagens/toxicity ; Reproducibility of Results ; Spindle Apparatus/drug effects
Czasopismo naukowe
Tytuł :
Re-evaluation of the mutagenic potential of quinacrine dihydrochloride dihydrate.
Autorzy :
Clarke JJ; Genetic Toxicology Division, BioReliance Corporation, 9630 Medical Center Drive, Rockville, MD 20850, USA. />Sokal DC
Cancel AM
Campen DB
Gudi R
Wagner VO
San RH
Jacobson-Kram D
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Źródło :
Mutation research [Mutat Res] 2001 Jul 25; Vol. 494 (1-2), pp. 41-53.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Mutagens/*toxicity
Quinacrine/*toxicity
Animals ; CHO Cells ; Chromosome Aberrations ; Cricetinae ; Dose-Response Relationship, Drug ; Female ; Male ; Mice ; Mice, Inbred ICR ; Micronucleus Tests ; Mutagenicity Tests ; Sterilization, Reproductive
Czasopismo naukowe
Tytuł :
Evaluation of potential genotoxicity of pulsed electric and electromagnetic fields used for bone growth stimulation.
Autorzy :
Jacobson-Kram D; Genetic Toxicology Division, Microbiological Associates, Inc., Rockville, MD 20850, USA. djacobson-kram@microbio.com
Tepper J
Kuo P
San RH
Curry PT
Wagner VO
Putman DL
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Źródło :
Mutation research [Mutat Res] 1997 Jan 15; Vol. 388 (1), pp. 45-57.
Typ publikacji :
Journal Article
MeSH Terms :
Chromosome Aberrations*
Electricity*
Electromagnetic Fields*
Mutagenesis*
DNA Replication/*drug effects
Liver/*metabolism
3T3 Cells ; Animals ; CHO Cells ; Cell Transformation, Neoplastic/radiation effects ; Cells, Cultured ; Cricetinae ; Escherichia coli/drug effects ; Liver/drug effects ; Male ; Mice ; Mutagenicity Tests ; Rats ; Rats, Sprague-Dawley ; Salmonella typhimurium/drug effects
Czasopismo naukowe
Tytuł :
Sister-chromatid exchange: second report of the Gene-Tox Program.
Autorzy :
Tucker JD; Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94551.
Auletta A
Cimino MC
Dearfield KL
Jacobson-Kram D
Tice RR
Carrano AV
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Źródło :
Mutation research [Mutat Res] 1993 Sep; Vol. 297 (2), pp. 101-80.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Sister Chromatid Exchange*
Mutagens/*pharmacology
Cells, Cultured ; Humans ; Mutagenicity Tests
Czasopismo naukowe
Tytuł :
Baseline and phosphoramide mustard-induced sister-chromatid exchanges in pharmacists handling anti-cancer drugs.
Autorzy :
McDiarmid MA; Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205.
Kolodner K
Humphrey F
Putman D
Jacobson-Kram D
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Źródło :
Mutation research [Mutat Res] 1992 Jun 01; Vol. 279 (3), pp. 199-204.
Typ publikacji :
Journal Article
MeSH Terms :
Occupational Exposure*
Pharmacists*
Antineoplastic Agents/*adverse effects
Phosphoramide Mustards/*pharmacology
Sister Chromatid Exchange/*drug effects
Adult ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes.
Autorzy :
Nicklas JA; Vermont Regional Cancer Center, Burlington.
O'Neill JP
Hunter TC
Falta MT
Lippert MJ
Jacobson-Kram D
Williams JR
Albertini RJ
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Źródło :
Mutation research [Mutat Res] 1991 Sep-Oct; Vol. 250 (1-2), pp. 383-96.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Chromosome Deletion*
Hypoxanthine Phosphoribosyltransferase/*radiation effects
Radioimmunotherapy/*adverse effects
T-Lymphocytes/*radiation effects
Adolescent ; Adult ; Aged ; Blotting, Southern ; Clone Cells ; DNA, Neoplasm/genetics ; DNA, Neoplasm/radiation effects ; Female ; Humans ; Hypoxanthine Phosphoribosyltransferase/genetics ; Male ; Middle Aged ; Receptors, Antigen, T-Cell/genetics ; Statistics as Topic ; T-Lymphocytes/enzymology
Czasopismo naukowe
Tytuł :
Evidence for acrolein-modified DNA in peripheral blood leukocytes of cancer patients treated with cyclophosphamide.
Autorzy :
McDiarmid MA; Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205.
Iype PT
Kolodner K
Jacobson-Kram D
Strickland PT
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Źródło :
Mutation research [Mutat Res] 1991 May; Vol. 248 (1), pp. 93-9.
Typ publikacji :
Journal Article
MeSH Terms :
Acrolein/*pharmacology
Cyclophosphamide/*pharmacology
DNA/*drug effects
Neoplasms/*drug therapy
Adult ; Biomarkers, Tumor ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoblotting ; In Vitro Techniques ; Leukocyte Count/drug effects ; Leukocytes/drug effects ; Male ; Middle Aged ; Smoking ; Time Factors
Czasopismo naukowe
Tytuł :
Baseline and phosphoramide mustard-induced sister-chromatid exchanges in cancer patients treated with cyclophosphamide.
Autorzy :
McDiarmid MA; Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205.
Strickland PT
Kolodner K
Hansen J
Jacobson-Kram D
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Źródło :
Mutation research [Mutat Res] 1990 Jul; Vol. 241 (3), pp. 273-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Sister Chromatid Exchange*
Neoplasms/*drug therapy
Phosphoramide Mustards/*adverse effects
Breast Neoplasms/drug therapy ; Cells, Cultured ; Female ; Humans ; Leukemia/drug therapy ; Lymphocytes/drug effects ; Male ; Phosphoramide Mustards/therapeutic use ; Reference Values
Czasopismo naukowe
Tytuł :
DNA topoisomerases and models of sister-chromatid exchange.
Autorzy :
Dillehay LE; Radiobiology Laboratory, Johns Hopkins Oncology Center, Baltimore, MD 21205.
Jacobson-Kram D
Williams JR
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Źródło :
Mutation research [Mutat Res] 1989 Nov; Vol. 215 (1), pp. 15-23.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA Replication*
Models, Genetic*
Sister Chromatid Exchange*
DNA Topoisomerases, Type I/*metabolism
DNA Topoisomerases, Type II/*metabolism
Replicon
Czasopismo naukowe
Tytuł :
Evaluation of a human hepatoma cell line as a target cell in genetic toxicology.
Autorzy :
Dearfield KL
Jacobson-Kram D
Brown NA
Williams JR
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Źródło :
Mutation research [Mutat Res] 1983 Mar; Vol. 108 (1-3), pp. 437-49.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Mutagenicity Tests*
Liver Neoplasms, Experimental/*genetics
Animals ; Biotransformation ; Cell Line ; Cyclophosphamide/metabolism ; Cyclophosphamide/pharmacology ; Humans ; Liver Neoplasms, Experimental/metabolism ; Phenobarbital/pharmacology ; Sister Chromatid Exchange/drug effects
Czasopismo naukowe
Tytuł :
Ultraviolet-light exposure induces a heritable sensitivity to the induction of SCE by mitomycin-C.
Autorzy :
Kim JP
D'Arpa P
Jacobson-Kram D
Williams JR
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Źródło :
Mutation research [Mutat Res] 1985 May; Vol. 149 (3), pp. 437-42.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Mitomycins/*toxicity
Sister Chromatid Exchange/*drug effects
Animals ; Cells, Cultured ; Cricetinae ; Lung/cytology ; Mitomycin ; Mutagenicity Tests ; Sister Chromatid Exchange/radiation effects ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Sister-chromatid exchange and cell replication kinetics in fetal and maternal cells after treatment with chemical teratogens.
Autorzy :
Sharma RK
Jacobson-Kram D
Lemmon M
Bakke J
Galperin I
Blazak WF
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Źródło :
Mutation research [Mutat Res] 1985 Dec; Vol. 158 (3), pp. 217-31.
Typ publikacji :
Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Organometallic Compounds*
Cell Cycle/*drug effects
Fetus/*drug effects
Sister Chromatid Exchange/*drug effects
Teratogens/*pharmacology
Animals ; Benzene/pharmacology ; Bone Marrow/drug effects ; Bone Marrow/ultrastructure ; Cyclophosphamide/pharmacology ; Diethylstilbestrol/pharmacology ; Dimethyl Sulfoxide/pharmacology ; Female ; Lead/pharmacology ; Liver/drug effects ; Liver/ultrastructure ; Maternal-Fetal Exchange ; Mice ; Mice, Inbred ICR ; Nitroso Compounds/pharmacology ; Phenytoin/pharmacology ; Pregnancy
Czasopismo naukowe
Tytuł :
Increased chromosomal radiosensitivity in patients undergoing radioimmunoglobulin therapy.
Autorzy :
Xiao SQ; Radiobiology Laboratory, Johns Hopkins University Oncology Center, Baltimore, MD 21205.
Jacobson-Kram D
Piantadosi S
Williams JR
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Źródło :
Mutation research [Mutat Res] 1989 Sep; Vol. 227 (1), pp. 39-45.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Chromosome Aberrations*
Chromosomes/*radiation effects
Iodine Radioisotopes/*therapeutic use
Lymphocytes/*radiation effects
Carcinoma, Hepatocellular/radiotherapy ; Cells, Cultured ; Ferritins/immunology ; Gamma Rays ; Humans ; Immunoglobulins/administration & dosage ; Iodine Radioisotopes/administration & dosage ; Liver Neoplasms/radiotherapy ; Lymphocytes/ultrastructure ; Radiation Tolerance
Czasopismo naukowe
Tytuł :
In vitro assays of in vivo exposure to cyclophosphamide: induction of sister-chromatid exchanges in peripheral lymphocytes, bone-marrow cells and in cultured cells exposed to plasma.
Autorzy :
Dearfield KL
Jacobson-Kram D
Buenaventura SK
Williams JR
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Źródło :
Mutation research [Mutat Res] 1985 Oct-Nov; Vol. 158 (1-2), pp. 97-104.
Typ publikacji :
Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Bone Marrow/*drug effects
Cyclophosphamide/*pharmacology
Lymphocytes/*drug effects
Sister Chromatid Exchange/*drug effects
Animals ; Carcinoma, Hepatocellular ; Cell Division/drug effects ; Cells, Cultured ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Humans ; Liver Neoplasms ; Lung ; Male ; Organ Specificity ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Tytuł :
Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells. An in vitro system for the induction of SCEs.
Autorzy :
Dean RG
Bynum G
Jacobson-Kram D
Hadley E
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Źródło :
Mutation research [Mutat Res] 1983 Nov; Vol. 111 (3), pp. 419-27.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Crossing Over, Genetic/*drug effects
Liver Neoplasms, Experimental/*physiopathology
Polycyclic Compounds/*toxicity
Sister Chromatid Exchange/*drug effects
9,10-Dimethyl-1,2-benzanthracene/toxicity ; Animals ; Benzo(a)pyrene ; Benzopyrenes/toxicity ; In Vitro Techniques ; Kinetics ; Methylcholanthrene/toxicity ; Mutagens/toxicity ; Structure-Activity Relationship
Czasopismo naukowe
    Wyświetlanie 1-20 z 20

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