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Tytuł :
Calcium- and voltage-gated BK channels in vascular smooth muscle.
Autorzy :
Dopico AM; Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, 71 South Manassas St., Memphis, TN, 38163, USA. .
Bukiya AN; Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, 71 South Manassas St., Memphis, TN, 38163, USA.
Jaggar JH; Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
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Źródło :
Pflugers Archiv : European journal of physiology [Pflugers Arch] 2018 Sep; Vol. 470 (9), pp. 1271-1289. Date of Electronic Publication: 2018 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Calcium/*metabolism
Large-Conductance Calcium-Activated Potassium Channels/*metabolism
Muscle, Smooth, Vascular/*metabolism
Animals ; Humans ; Membrane Potentials/physiology ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Elevated plasma catecholamines functionally compensate for the reduced myogenic tone in smooth muscle STIM1 knockout mice but with deleterious cardiac effects.
Autorzy :
Pichavaram P; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
Yin W; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.; Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Evanson KW; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
Jaggar JH; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
Mancarella S; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2018 Apr 01; Vol. 114 (5), pp. 668-678.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Vasoconstriction*
Actin Cytoskeleton/*metabolism
Catecholamines/*blood
Heart Diseases/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Stromal Interaction Molecule 1/*deficiency
Actin Cytoskeleton/pathology ; Animals ; Blood Pressure ; Cells, Cultured ; Fibrosis ; Heart/innervation ; Heart Diseases/genetics ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Heart Rate ; Mice, Knockout ; Muscle, Smooth, Vascular/pathology ; Muscle, Smooth, Vascular/physiopathology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Smooth Muscle/pathology ; Signal Transduction ; Stromal Interaction Molecule 1/genetics ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology ; Up-Regulation ; Vinculin
Czasopismo naukowe
Tytuł :
Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction.
Autorzy :
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Zhai X; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Muralidharan P; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Kuruvilla KP; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Bulley S; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Boop FA; Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. .
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Źródło :
Science signaling [Sci Signal] 2017 May 09; Vol. 10 (478). Date of Electronic Publication: 2017 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Vasoconstriction*
Cell Membrane/*metabolism
Large-Conductance Calcium-Activated Potassium Channel beta Subunits/*metabolism
Muscle, Smooth, Vascular/*physiology
rab GTP-Binding Proteins/*metabolism
rho-Associated Kinases/*metabolism
Animals ; Calcium/metabolism ; Cell Movement ; Large-Conductance Calcium-Activated Potassium Channel beta Subunits/genetics ; Male ; Membrane Potentials ; Muscle, Smooth, Vascular/cytology ; Protein Subunits ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Vasodilation
Czasopismo naukowe
Tytuł :
Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.
Autorzy :
Wang Q; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Narayanan D; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Kuruvilla KP; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee .
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2016 Jun 01; Vol. 310 (11), pp. C1001-9. Date of Electronic Publication: 2016 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Vasoconstriction*/drug effects
Chloride Channels/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
TRPC Cation Channels/*metabolism
Animals ; Anoctamin-1 ; Calcium Chelating Agents/pharmacology ; Calcium Signaling ; Cerebral Arteries/metabolism ; Chloride Channels/antagonists & inhibitors ; Chloride Channels/genetics ; Male ; Membrane Potentials ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; RNA Interference ; Rats, Sprague-Dawley ; TRPC Cation Channels/agonists ; Tissue Culture Techniques ; Transfection ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe
Tytuł :
Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Bulley S; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Kidd MW; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee .
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2016 Jun 01; Vol. 310 (11), pp. C885-93. Date of Electronic Publication: 2016 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Channels, L-Type/*metabolism
Muscle, Smooth, Vascular/*enzymology
Myocytes, Smooth Muscle/*enzymology
rab GTP-Binding Proteins/*metabolism
Animals ; Cells, Cultured ; Cerebral Arteries/enzymology ; Lysosomes/metabolism ; Male ; Membrane Potentials ; Proteasome Endopeptidase Complex/metabolism ; Protein Transport ; Proteolysis ; RNA Interference ; Rats, Sprague-Dawley ; Signal Transduction ; Transfection ; Vasoconstriction ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.
Autorzy :
Evanson KW; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Bannister JP; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Leo MD; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Jaggar JH; From the Department of Physiology, University of Tennessee Health Science Center, Memphis. .
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Źródło :
Circulation research [Circ Res] 2014 Aug 01; Vol. 115 (4), pp. 423-31. Date of Electronic Publication: 2014 Jun 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Large-Conductance Calcium-Activated Potassium Channels/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Neoplasm Proteins/*metabolism
Animals ; Blotting, Western ; Calcium Signaling ; Cerebral Arteries/metabolism ; Gene Expression Regulation ; Immunoprecipitation ; Large-Conductance Calcium-Activated Potassium Channels/genetics ; Male ; Membrane Potentials ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; Neoplasm Proteins/genetics ; Protein Subunits ; RNA Interference ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Tissue Culture Techniques ; Transfection ; Vasoconstriction ; Vasoconstrictor Agents/pharmacology ; Vasodilation ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries.
Autorzy :
Narayanan D; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. .
Bulley S
Leo MD
Burris SK
Gabrick KS
Boop FA
Jaggar JH
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Źródło :
The Journal of physiology [J Physiol] 2013 Oct 15; Vol. 591 (20), pp. 5031-46. Date of Electronic Publication: 2013 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Vasoconstriction*
Cerebral Arteries/*metabolism
Muscle, Smooth, Vascular/*metabolism
TRPP Cation Channels/*metabolism
Adolescent ; Animals ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Cell Membrane/metabolism ; Cerebral Arteries/cytology ; Cerebral Arteries/physiology ; Child ; Female ; HEK293 Cells ; Humans ; Infant ; Male ; Muscle, Smooth, Vascular/physiology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Transport ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; TRPP Cation Channels/genetics
Czasopismo naukowe
Tytuł :
The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Centre, 894 Union Avenue, Suite 426, Memphis, TN 38163, USA.
Leo MD
Narayanan D
Jangsangthong W
Nair A
Evanson KW
Pachuau J
Gabrick KS
Boop FA
Jaggar JH
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Źródło :
The Journal of physiology [J Physiol] 2013 Jun 15; Vol. 591 (12), pp. 2987-98. Date of Electronic Publication: 2013 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Vasodilation*
Calcium Channels, L-Type/*metabolism
Muscle, Smooth, Vascular/*metabolism
Action Potentials ; Active Transport, Cell Nucleus ; Adolescent ; Animals ; Calcium Channels, L-Type/chemistry ; Calcium Channels, L-Type/genetics ; Cell Nucleus/metabolism ; Cerebral Arteries/cytology ; Cerebral Arteries/physiology ; Humans ; Male ; Muscle, Smooth, Vascular/physiology ; Mutation ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/physiology ; Nuclear Localization Signals ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Transcriptional upregulation of α2δ-1 elevates arterial smooth muscle cell voltage-dependent Ca2+ channel surface expression and cerebrovascular constriction in genetic hypertension.
Autorzy :
Bannister JP; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 894 Union Ave, Suite 426, Memphis, TN 38163, USA.
Bulley S
Narayanan D
Thomas-Gatewood C
Luzny P
Pachuau J
Jaggar JH
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2012 Oct; Vol. 60 (4), pp. 1006-15. Date of Electronic Publication: 2012 Sep 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Channels/*genetics
Hypertension/*genetics
Muscle, Smooth, Vascular/*metabolism
Up-Regulation/*genetics
Vasoconstriction/*genetics
Animals ; Calcium Channels/metabolism ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Cerebral Arteries/drug effects ; Cerebral Arteries/metabolism ; Hypertension/metabolism ; Hypertension/physiopathology ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Pregabalin ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Transcriptional Activation/drug effects ; Transcriptional Activation/genetics ; Up-Regulation/drug effects ; Vasoconstriction/drug effects ; gamma-Aminobutyric Acid/analogs & derivatives ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells.
Autorzy :
Thomas-Gatewood C; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Neeb ZP
Bulley S
Adebiyi A
Bannister JP
Leo MD
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2011 Nov; Vol. 301 (5), pp. H1819-27. Date of Electronic Publication: 2011 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
Chloride Channels/*metabolism
Chlorides/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Animals ; Anoctamin-1 ; Blotting, Western ; Cell Membrane/metabolism ; Chloride Channels/genetics ; Fluorescent Antibody Technique ; HEK293 Cells ; Humans ; Male ; Membrane Potentials ; Microscopy, Confocal ; Middle Cerebral Artery/metabolism ; Patch-Clamp Techniques ; Polymerase Chain Reaction ; RNA Interference ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Transfection
Czasopismo naukowe
Tytuł :
Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.
Autorzy :
Liang GH; Dept. of Physiology, Univ. of Tennessee Health Science Ctr., Memphis, TN 38163, USA.
Adebiyi A
Leo MD
McNally EM
Leffler CW
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2011 Jun; Vol. 300 (6), pp. H2088-95. Date of Electronic Publication: 2011 Mar 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Membrane/*metabolism
Cerebral Arteries/*drug effects
Hydrogen Sulfide/*pharmacology
KATP Channels/*metabolism
Muscle, Smooth, Vascular/*metabolism
Vasodilation/*drug effects
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Arterioles/drug effects ; Arterioles/physiology ; Cerebral Arteries/physiology ; Female ; Glyburide/pharmacology ; KATP Channels/drug effects ; Male ; Mice ; Mice, Knockout ; Models, Animal ; Patch-Clamp Techniques ; Pinacidil/pharmacology ; Potassium Channels, Inwardly Rectifying/genetics ; Potassium Channels, Inwardly Rectifying/metabolism ; Receptors, Drug/genetics ; Receptors, Drug/metabolism ; Sulfonylurea Receptors ; Swine ; Vasodilation/physiology ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells.
Autorzy :
Adebiyi A; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Narayanan D
Jaggar JH
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2011 Feb 11; Vol. 286 (6), pp. 4341-8. Date of Electronic Publication: 2010 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caveolin 1/*metabolism
Cerebral Arteries/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Membrane Microdomains/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
TRPC Cation Channels/*metabolism
Animals ; Caveolin 1/genetics ; Cerebral Arteries/cytology ; Cholesterol/metabolism ; Cholesterol/pharmacology ; Gene Knockdown Techniques ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate/pharmacology ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Ion Transport/drug effects ; Ion Transport/physiology ; Male ; Membrane Microdomains/genetics ; Muscle, Smooth, Vascular/cytology ; Rats ; Rats, Sprague-Dawley ; TRPC Cation Channels/genetics ; Vasoconstriction/drug effects ; Vasoconstriction/physiology ; beta-Cyclodextrins/pharmacology
Czasopismo naukowe
Tytuł :
Hydrogen sulfide and cerebral microvascular tone in newborn pigs.
Autorzy :
Leffler CW; Laboratory for Research in Neonatal Physiology, Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave., Memphis, TN 38163, USA. />Parfenova H
Basuroy S
Jaggar JH
Umstot ES
Fedinec AL
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2011 Feb; Vol. 300 (2), pp. H440-7. Date of Electronic Publication: 2010 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Animals, Newborn/*physiology
Capillaries/*drug effects
Cerebrovascular Circulation/*drug effects
Hydrogen Sulfide/*metabolism
Hydrogen Sulfide/*pharmacology
Muscle, Smooth, Vascular/*drug effects
Animals ; Arterioles/drug effects ; Arterioles/physiology ; Brain Chemistry/physiology ; Cysteine/pharmacology ; Glyburide/pharmacology ; Hypercapnia/physiopathology ; Hypoxia/physiopathology ; Immunohistochemistry ; Isoproterenol/pharmacology ; KATP Channels/antagonists & inhibitors ; Muscle Tonus/drug effects ; Nitroprusside/pharmacology ; Swine ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries.
Autorzy :
Narayanan D; Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis TN 38163, USA.
Xi Q
Pfeffer LM
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2010 Sep 03; Vol. 107 (5), pp. 631-41. Date of Electronic Publication: 2010 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*/drug effects
Vasoconstriction*/drug effects
Calcium/*metabolism
Calcium Channels, L-Type/*metabolism
Mitochondria, Muscle/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Animals ; Antioxidants/pharmacology ; Calcium Channels, L-Type/drug effects ; Calcium Channels, L-Type/genetics ; Cerebral Arteries/metabolism ; Endothelin-1/metabolism ; Homeostasis ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Luminescent Proteins/biosynthesis ; Luminescent Proteins/genetics ; Male ; Membrane Potential, Mitochondrial ; Microscopy, Confocal ; Mitochondria, Muscle/drug effects ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Promoter Regions, Genetic ; RNA Interference ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Sarcoplasmic Reticulum/metabolism ; Time Factors ; Transcriptional Activation ; Transfection ; Uncoupling Agents/pharmacology
Czasopismo naukowe
Tytuł :
Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.
Autorzy :
Zhao G; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Neeb ZP
Leo MD
Pachuau J
Adebiyi A
Ouyang K
Chen J
Jaggar JH
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Źródło :
The Journal of general physiology [J Gen Physiol] 2010 Sep; Vol. 136 (3), pp. 283-91. Date of Electronic Publication: 2010 Aug 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Signaling*/drug effects
Calcium Channels/*metabolism
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Potassium Channels/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Adenosine/analogs & derivatives ; Adenosine/pharmacology ; Animals ; Antibodies, Monoclonal/pharmacology ; Aorta/metabolism ; Calcium Channels/deficiency ; Calcium Channels/drug effects ; Calcium Channels/genetics ; Cell Membrane/metabolism ; Cerebral Arteries/metabolism ; Chelating Agents/pharmacology ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Fluorescence Resonance Energy Transfer ; Fluorescent Antibody Technique ; Heparin/pharmacology ; Immunoprecipitation ; Inositol 1,4,5-Trisphosphate Receptors ; Ion Channel Gating ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/drug effects ; Male ; Membrane Potentials ; Mice ; Mice, Knockout ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; Patch-Clamp Techniques ; Potassium Channels/drug effects ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear/deficiency ; Receptors, Cytoplasmic and Nuclear/drug effects ; Receptors, Cytoplasmic and Nuclear/genetics ; Sarcoplasmic Reticulum/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells.
Autorzy :
Crnich R; Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Amberg GC
Leo MD
Gonzales AL
Tamkun MM
Jaggar JH
Earley S
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2010 Sep; Vol. 299 (3), pp. C682-94. Date of Electronic Publication: 2010 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
TRPM Cation Channels/*metabolism
Animals ; Cell Membrane/metabolism ; Cells, Cultured ; Cerebral Arteries/cytology ; Cerebral Arteries/metabolism ; Enzyme Activators/pharmacology ; Male ; Membrane Potentials ; Mice ; Muscle Contraction ; Protein Kinase C-delta/physiology ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Tetradecanoylphorbol Acetate/pharmacology
Czasopismo naukowe
Tytuł :
Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility.
Autorzy :
Adebiyi A; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38139, USA.
Zhao G
Narayanan D
Thomas-Gatewood CM
Bannister JP
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2010 May 28; Vol. 106 (10), pp. 1603-12. Date of Electronic Publication: 2010 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Arteries/*physiology
Inositol 1,4,5-Trisphosphate Receptors/*physiology
Muscle Cells/*physiology
Muscle, Smooth, Vascular/*physiology
TRPC Cation Channels/*physiology
Vasoconstriction/*physiology
Animals ; Cell Line ; Cerebral Arteries/cytology ; Gene Silencing ; Homeostasis ; Humans ; Kidney ; Microscopy, Confocal ; Muscle Cells/cytology ; Rats ; Rats, Sprague-Dawley ; TRPC Cation Channels/deficiency ; TRPC Cation Channels/genetics ; Transfection
Czasopismo naukowe
Tytuł :
Glutamate regulates Ca2+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte- and heme oxygenase-dependent mechanisms.
Autorzy :
Xi Q; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Umstot E
Zhao G
Narayanan D
Leffler CW
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2010 Feb; Vol. 298 (2), pp. H562-9. Date of Electronic Publication: 2009 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Arterioles/*metabolism
Astrocytes/*metabolism
Brain/*blood supply
Calcium Signaling/*physiology
Glutamic Acid/*metabolism
Heme Oxygenase (Decyclizing)/*metabolism
Muscle, Smooth, Vascular/*metabolism
Animals ; Animals, Newborn ; Arterioles/cytology ; Arterioles/drug effects ; Astrocytes/cytology ; Calcium/metabolism ; Calcium Signaling/drug effects ; Carbon Monoxide/metabolism ; Cell Communication ; Heme Oxygenase (Decyclizing)/antagonists & inhibitors ; Mesoporphyrins/pharmacology ; Models, Animal ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/drug effects ; Organometallic Compounds/pharmacology ; Swine
Czasopismo naukowe
Tytuł :
Smooth muscle cell alpha2delta-1 subunits are essential for vasoregulation by CaV1.2 channels.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Adebiyi A
Zhao G
Narayanan D
Thomas CM
Feng JY
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2009 Nov 06; Vol. 105 (10), pp. 948-55. Date of Electronic Publication: 2009 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels, L-Type/*metabolism
Cerebral Arteries/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Vasoconstriction/*physiology
Vasodilation/*physiology
Animals ; Anticonvulsants/pharmacology ; Calcium/metabolism ; Cells, Cultured ; Cerebral Arteries/cytology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Gene Knockdown Techniques ; Male ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/cytology ; Pregabalin ; Protein Isoforms/metabolism ; Protein Subunits/metabolism ; Rats ; Rats, Sprague-Dawley ; Vasoconstriction/drug effects ; Vasodilation/drug effects ; gamma-Aminobutyric Acid/analogs & derivatives ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties.
Autorzy :
Cheng X; Department of Physiology , University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Pachuau J
Blaskova E
Asuncion-Chin M
Liu J
Dopico AM
Jaggar JH
Pokaż więcej
Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2009 Aug; Vol. 297 (2), pp. H680-8. Date of Electronic Publication: 2009 Jun 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing/*physiology
Calcium Channels, L-Type/*genetics
Cerebral Arteries/*cytology
Cerebrovascular Circulation/*physiology
Muscle, Smooth, Vascular/*physiology
Amino Acid Sequence ; Animals ; Base Sequence ; Calcium Channels, L-Type/chemistry ; Calcium Channels, L-Type/physiology ; Cells, Cultured ; Exons/genetics ; Molecular Sequence Data ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/physiology ; Patch-Clamp Techniques ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley ; Vascular Resistance/physiology
Czasopismo naukowe

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