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Tytuł :
Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure.
Autorzy :
Bulley S; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Fernández-Peña C; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Hasan R; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Muralidharan P; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Mackay CE; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Evanson KW; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Moreira-Junior L; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Mata-Daboin A; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Burris SK; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Wang Q; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Kuruvilla KP; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, United States.
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Źródło :
ELife [Elife] 2018 Dec 04; Vol. 7. Date of Electronic Publication: 2018 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arteries/*metabolism
Hypertension/*genetics
Myocytes, Smooth Muscle/*metabolism
Receptors, Adrenergic, alpha-1/*genetics
Sodium/*metabolism
TRPP Cation Channels/*genetics
Animals ; Arteries/physiopathology ; Blood Pressure/physiology ; Cations, Monovalent ; Gene Expression Regulation ; Hindlimb/blood supply ; Hindlimb/cytology ; Hypertension/metabolism ; Hypertension/physiopathology ; Ion Transport ; Membrane Potentials/physiology ; Mice ; Mice, Knockout ; Myocytes, Smooth Muscle/pathology ; Receptors, Adrenergic, alpha-1/metabolism ; Signal Transduction ; TRPP Cation Channels/deficiency ; Vasoconstriction/physiology
Czasopismo naukowe
Tytuł :
Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats.
Autorzy :
Leo MD; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Zhai X; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Yin W; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Jaggar JH; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2018 Sep; Vol. 72 (3), pp. 765-775.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Arteries/*metabolism
Hypertension/*metabolism
Large-Conductance Calcium-Activated Potassium Channels/*metabolism
Myocytes, Smooth Muscle/*physiology
Animals ; Cerebral Arteries/physiopathology ; Hypertension/physiopathology ; Indoles/pharmacology ; Male ; Maleimides/pharmacology ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Nitric Oxide Donors/pharmacology ; Nitroprusside/pharmacology ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Protein Subunits/metabolism ; Protein Transport/drug effects ; Rats, Inbred SHR ; Rats, Inbred WKY ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Elevated plasma catecholamines functionally compensate for the reduced myogenic tone in smooth muscle STIM1 knockout mice but with deleterious cardiac effects.
Autorzy :
Pichavaram P; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
Yin W; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.; Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Evanson KW; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
Jaggar JH; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
Mancarella S; Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2018 Apr 01; Vol. 114 (5), pp. 668-678.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Vasoconstriction*
Actin Cytoskeleton/*metabolism
Catecholamines/*blood
Heart Diseases/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Stromal Interaction Molecule 1/*deficiency
Actin Cytoskeleton/pathology ; Animals ; Blood Pressure ; Cells, Cultured ; Fibrosis ; Heart/innervation ; Heart Diseases/genetics ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Heart Rate ; Mice, Knockout ; Muscle, Smooth, Vascular/pathology ; Muscle, Smooth, Vascular/physiopathology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Smooth Muscle/pathology ; Signal Transduction ; Stromal Interaction Molecule 1/genetics ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology ; Up-Regulation ; Vinculin
Czasopismo naukowe
Tytuł :
Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.
Autorzy :
Wang Q; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Narayanan D; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Kuruvilla KP; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee .
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2016 Jun 01; Vol. 310 (11), pp. C1001-9. Date of Electronic Publication: 2016 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Vasoconstriction*/drug effects
Chloride Channels/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
TRPC Cation Channels/*metabolism
Animals ; Anoctamin-1 ; Calcium Chelating Agents/pharmacology ; Calcium Signaling ; Cerebral Arteries/metabolism ; Chloride Channels/antagonists & inhibitors ; Chloride Channels/genetics ; Male ; Membrane Potentials ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; RNA Interference ; Rats, Sprague-Dawley ; TRPC Cation Channels/agonists ; Tissue Culture Techniques ; Transfection ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe
Tytuł :
Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Bulley S; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Kidd MW; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee .
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2016 Jun 01; Vol. 310 (11), pp. C885-93. Date of Electronic Publication: 2016 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Channels, L-Type/*metabolism
Muscle, Smooth, Vascular/*enzymology
Myocytes, Smooth Muscle/*enzymology
rab GTP-Binding Proteins/*metabolism
Animals ; Cells, Cultured ; Cerebral Arteries/enzymology ; Lysosomes/metabolism ; Male ; Membrane Potentials ; Proteasome Endopeptidase Complex/metabolism ; Protein Transport ; Proteolysis ; RNA Interference ; Rats, Sprague-Dawley ; Signal Transduction ; Transfection ; Vasoconstriction ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells.
Autorzy :
Kidd MW; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Bannister JP; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. .
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Źródło :
Science signaling [Sci Signal] 2015 Aug 18; Vol. 8 (390), pp. ra83. Date of Electronic Publication: 2015 Aug 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Membrane/*physiology
Kv1.5 Potassium Channel/*physiology
Mesenteric Arteries/*physiology
Myocytes, Smooth Muscle/*physiology
Vasoconstriction/*physiology
Animals ; Blotting, Western ; Cells, Cultured ; HEK293 Cells ; Humans ; In Vitro Techniques ; Kv1.5 Potassium Channel/genetics ; Kv1.5 Potassium Channel/metabolism ; Male ; Membrane Potentials/physiology ; Mesenteric Arteries/cytology ; Mesenteric Arteries/metabolism ; Myocytes, Smooth Muscle/metabolism ; Patch-Clamp Techniques ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Eugenol dilates rat cerebral arteries by inhibiting smooth muscle cell voltage-dependent calcium channels.
Autorzy :
Peixoto-Neves D; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN; and †Laboratório de Eletrofisiologia, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
Leal-Cardoso JH
Jaggar JH
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Źródło :
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2014 Nov; Vol. 64 (5), pp. 401-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels/*drug effects
Cerebral Arteries/*drug effects
Eugenol/*pharmacology
Myocytes, Smooth Muscle/*drug effects
Animals ; Calcium Channel Blockers/administration & dosage ; Calcium Channel Blockers/pharmacology ; Calcium Channels/metabolism ; Cerebral Arteries/metabolism ; Dose-Response Relationship, Drug ; Eugenol/administration & dosage ; Male ; Myocytes, Smooth Muscle/metabolism ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Vasodilation/drug effects ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.
Autorzy :
Evanson KW; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Bannister JP; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Leo MD; From the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Jaggar JH; From the Department of Physiology, University of Tennessee Health Science Center, Memphis. .
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Źródło :
Circulation research [Circ Res] 2014 Aug 01; Vol. 115 (4), pp. 423-31. Date of Electronic Publication: 2014 Jun 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Large-Conductance Calcium-Activated Potassium Channels/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Neoplasm Proteins/*metabolism
Animals ; Blotting, Western ; Calcium Signaling ; Cerebral Arteries/metabolism ; Gene Expression Regulation ; Immunoprecipitation ; Large-Conductance Calcium-Activated Potassium Channels/genetics ; Male ; Membrane Potentials ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; Neoplasm Proteins/genetics ; Protein Subunits ; RNA Interference ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Tissue Culture Techniques ; Transfection ; Vasoconstriction ; Vasoconstrictor Agents/pharmacology ; Vasodilation ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Cl⁻ channels in smooth muscle cells.
Autorzy :
Bulley S
Jaggar JH
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Źródło :
Pflugers Archiv : European journal of physiology [Pflugers Arch] 2014 May; Vol. 466 (5), pp. 861-72.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Chloride Channels/*metabolism
Myocytes, Smooth Muscle/*metabolism
Animals ; Humans ; Membrane Potentials ; Myocytes, Smooth Muscle/physiology
Czasopismo naukowe
Tytuł :
TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries.
Autorzy :
Bulley S; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Neeb ZP
Burris SK
Bannister JP
Thomas-Gatewood CM
Jangsangthong W
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2012 Sep 28; Vol. 111 (8), pp. 1027-36. Date of Electronic Publication: 2012 Aug 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Blood Pressure/*physiology
Calcium Signaling/*physiology
Cerebral Arteries/*physiology
Chloride Channels/*physiology
Myocytes, Smooth Muscle/*physiology
Animals ; Anoctamin-1 ; Calcium Channel Blockers/pharmacology ; Calcium Signaling/drug effects ; Cerebral Arteries/cytology ; Cerebrovascular Circulation/physiology ; Chloride Channels/genetics ; Chlorides/metabolism ; HEK293 Cells ; Humans ; Imidazoles/pharmacology ; Male ; Myocytes, Smooth Muscle/cytology ; Nimodipine/pharmacology ; Patch-Clamp Techniques ; RNA, Small Interfering/genetics ; Rats ; Rats, Sprague-Dawley ; Thapsigargin/pharmacology ; Vasoconstriction/physiology
Czasopismo naukowe
Tytuł :
Inositol trisphosphate receptors in smooth muscle cells.
Autorzy :
Narayanan D; Department of Physiology, University of Tennessee Health Science Center, Memphis, 38163, USA.
Adebiyi A
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2012 Jun 01; Vol. 302 (11), pp. H2190-210. Date of Electronic Publication: 2012 Mar 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Inositol 1,4,5-Trisphosphate Receptors/*physiology
Myocytes, Smooth Muscle/*physiology
Signal Transduction/*physiology
Animals ; Calcium Signaling/physiology ; Humans ; Reactive Oxygen Species/metabolism ; Sarcoplasmic Reticulum/physiology
Czasopismo naukowe
Tytuł :
Hydrogen sulfide activates Ca²⁺ sparks to induce cerebral arteriole dilatation.
Autorzy :
Liang GH; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Xi Q
Leffler CW
Jaggar JH
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Źródło :
The Journal of physiology [J Physiol] 2012 Jun 01; Vol. 590 (11), pp. 2709-20. Date of Electronic Publication: 2012 Apr 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*blood supply
Calcium/*physiology
Hydrogen Sulfide/*pharmacology
Myocytes, Smooth Muscle/*drug effects
Vasodilation/*drug effects
Animals ; Arterioles/drug effects ; Arterioles/physiology ; Brain/drug effects ; Brain/physiology ; In Vitro Techniques ; Membrane Potentials/drug effects ; Myocytes, Smooth Muscle/physiology ; Potassium Channels, Calcium-Activated/physiology ; Ryanodine Receptor Calcium Release Channel/physiology ; Sarcoplasmic Reticulum/physiology ; Swine
Czasopismo naukowe
Tytuł :
TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells.
Autorzy :
Thomas-Gatewood C; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Neeb ZP
Bulley S
Adebiyi A
Bannister JP
Leo MD
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2011 Nov; Vol. 301 (5), pp. H1819-27. Date of Electronic Publication: 2011 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
Chloride Channels/*metabolism
Chlorides/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Animals ; Anoctamin-1 ; Blotting, Western ; Cell Membrane/metabolism ; Chloride Channels/genetics ; Fluorescent Antibody Technique ; HEK293 Cells ; Humans ; Male ; Membrane Potentials ; Microscopy, Confocal ; Middle Cerebral Artery/metabolism ; Patch-Clamp Techniques ; Polymerase Chain Reaction ; RNA Interference ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Transfection
Czasopismo naukowe
Tytuł :
Ca(V)1.2 channel N-terminal splice variants modulate functional surface expression in resistance size artery smooth muscle cells.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Thomas-Gatewood CM
Neeb ZP
Adebiyi A
Cheng X
Jaggar JH
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2011 Apr 29; Vol. 286 (17), pp. 15058-66. Date of Electronic Publication: 2011 Feb 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Vasoconstriction*
Calcium Channels, L-Type/*genetics
Cerebral Arteries/*physiology
Gene Expression Regulation/*physiology
Myocytes, Smooth Muscle/*metabolism
Animals ; Calcium/metabolism ; Calcium Channels, L-Type/physiology ; Cell Membrane/metabolism ; Cerebral Arteries/cytology ; Chickens ; Guinea Pigs ; Humans ; Muscle, Smooth, Vascular/cytology ; Protein Isoforms/physiology ; Rats
Czasopismo naukowe
Tytuł :
Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells.
Autorzy :
Adebiyi A; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Narayanan D
Jaggar JH
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2011 Feb 11; Vol. 286 (6), pp. 4341-8. Date of Electronic Publication: 2010 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caveolin 1/*metabolism
Cerebral Arteries/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Membrane Microdomains/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
TRPC Cation Channels/*metabolism
Animals ; Caveolin 1/genetics ; Cerebral Arteries/cytology ; Cholesterol/metabolism ; Cholesterol/pharmacology ; Gene Knockdown Techniques ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate/pharmacology ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Ion Transport/drug effects ; Ion Transport/physiology ; Male ; Membrane Microdomains/genetics ; Muscle, Smooth, Vascular/cytology ; Rats ; Rats, Sprague-Dawley ; TRPC Cation Channels/genetics ; Vasoconstriction/drug effects ; Vasoconstriction/physiology ; beta-Cyclodextrins/pharmacology
Czasopismo naukowe
Tytuł :
Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries.
Autorzy :
Narayanan D; Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis TN 38163, USA.
Xi Q
Pfeffer LM
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2010 Sep 03; Vol. 107 (5), pp. 631-41. Date of Electronic Publication: 2010 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*/drug effects
Vasoconstriction*/drug effects
Calcium/*metabolism
Calcium Channels, L-Type/*metabolism
Mitochondria, Muscle/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Animals ; Antioxidants/pharmacology ; Calcium Channels, L-Type/drug effects ; Calcium Channels, L-Type/genetics ; Cerebral Arteries/metabolism ; Endothelin-1/metabolism ; Homeostasis ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Luminescent Proteins/biosynthesis ; Luminescent Proteins/genetics ; Male ; Membrane Potential, Mitochondrial ; Microscopy, Confocal ; Mitochondria, Muscle/drug effects ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Promoter Regions, Genetic ; RNA Interference ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Sarcoplasmic Reticulum/metabolism ; Time Factors ; Transcriptional Activation ; Transfection ; Uncoupling Agents/pharmacology
Czasopismo naukowe
Tytuł :
Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.
Autorzy :
Zhao G; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Neeb ZP
Leo MD
Pachuau J
Adebiyi A
Ouyang K
Chen J
Jaggar JH
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Źródło :
The Journal of general physiology [J Gen Physiol] 2010 Sep; Vol. 136 (3), pp. 283-91. Date of Electronic Publication: 2010 Aug 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Signaling*/drug effects
Calcium Channels/*metabolism
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Potassium Channels/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Adenosine/analogs & derivatives ; Adenosine/pharmacology ; Animals ; Antibodies, Monoclonal/pharmacology ; Aorta/metabolism ; Calcium Channels/deficiency ; Calcium Channels/drug effects ; Calcium Channels/genetics ; Cell Membrane/metabolism ; Cerebral Arteries/metabolism ; Chelating Agents/pharmacology ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Fluorescence Resonance Energy Transfer ; Fluorescent Antibody Technique ; Heparin/pharmacology ; Immunoprecipitation ; Inositol 1,4,5-Trisphosphate Receptors ; Ion Channel Gating ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/drug effects ; Male ; Membrane Potentials ; Mice ; Mice, Knockout ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; Patch-Clamp Techniques ; Potassium Channels/drug effects ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear/deficiency ; Receptors, Cytoplasmic and Nuclear/drug effects ; Receptors, Cytoplasmic and Nuclear/genetics ; Sarcoplasmic Reticulum/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells.
Autorzy :
Crnich R; Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Amberg GC
Leo MD
Gonzales AL
Tamkun MM
Jaggar JH
Earley S
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2010 Sep; Vol. 299 (3), pp. C682-94. Date of Electronic Publication: 2010 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
TRPM Cation Channels/*metabolism
Animals ; Cell Membrane/metabolism ; Cells, Cultured ; Cerebral Arteries/cytology ; Cerebral Arteries/metabolism ; Enzyme Activators/pharmacology ; Male ; Membrane Potentials ; Mice ; Muscle Contraction ; Protein Kinase C-delta/physiology ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Tetradecanoylphorbol Acetate/pharmacology
Czasopismo naukowe
Tytuł :
Smooth muscle cell alpha2delta-1 subunits are essential for vasoregulation by CaV1.2 channels.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Adebiyi A
Zhao G
Narayanan D
Thomas CM
Feng JY
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2009 Nov 06; Vol. 105 (10), pp. 948-55. Date of Electronic Publication: 2009 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels, L-Type/*metabolism
Cerebral Arteries/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Vasoconstriction/*physiology
Vasodilation/*physiology
Animals ; Anticonvulsants/pharmacology ; Calcium/metabolism ; Cells, Cultured ; Cerebral Arteries/cytology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Gene Knockdown Techniques ; Male ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/cytology ; Pregabalin ; Protein Isoforms/metabolism ; Protein Subunits/metabolism ; Rats ; Rats, Sprague-Dawley ; Vasoconstriction/drug effects ; Vasodilation/drug effects ; gamma-Aminobutyric Acid/analogs & derivatives ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release.
Autorzy :
Xi Q; University of Tennessee Health Science Center, Department of Physiology, 894 Union Ave, Nash Building, Memphis, TN 38139, USA.
Adebiyi A
Zhao G
Chapman KE
Waters CM
Hassid A
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2008 May 09; Vol. 102 (9), pp. 1118-26. Date of Electronic Publication: 2008 Apr 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*/drug effects
Vasoconstriction*/drug effects
Inositol 1,4,5-Trisphosphate/*metabolism
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
TRPC Cation Channels/*metabolism
Animals ; Blood Pressure ; Calcium/metabolism ; Cerebral Arteries/drug effects ; Cerebral Arteries/metabolism ; Endothelin-1/pharmacology ; Female ; Inositol 1,4,5-Trisphosphate Receptors/drug effects ; Male ; Membrane Potentials ; Membrane Transport Modulators/pharmacology ; Muscle, Smooth, Vascular/drug effects ; Myocytes, Smooth Muscle/drug effects ; RNA Interference ; RNA, Small Interfering/metabolism ; Rats ; Rats, Sprague-Dawley ; Sarcoplasmic Reticulum/metabolism ; Sodium/metabolism ; TRPC Cation Channels/drug effects ; TRPC Cation Channels/genetics ; Time Factors ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe

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