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Wyświetlanie 1-16 z 16
Tytuł :
Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure.
Autorzy :
MacKay CE; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Leo MD; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Fernández-Peña C; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Hasan R; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Yin W; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Mata-Daboin A; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Bulley S; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Gammons J; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Mancarella S; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Jaggar JH; Department of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
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Źródło :
ELife [Elife] 2020 May 04; Vol. 9. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arterial Pressure*
Mechanotransduction, Cellular*
Vasodilation*
Endothelial Cells/*metabolism
Hypertension/*metabolism
Mesenteric Arteries/*metabolism
TRPP Cation Channels/*metabolism
Animals ; Calcium Signaling ; Hypertension/genetics ; Hypertension/physiopathology ; Intermediate-Conductance Calcium-Activated Potassium Channels/metabolism ; Male ; Membrane Potentials ; Mesenteric Arteries/physiopathology ; Mice, Knockout ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Phosphorylation ; Regional Blood Flow ; Small-Conductance Calcium-Activated Potassium Channels/metabolism ; TRPP Cation Channels/deficiency ; TRPP Cation Channels/genetics
Czasopismo naukowe
Tytuł :
Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels.
Autorzy :
Peixoto-Neves D; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.; Laboratório de Eletrofisiologia, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
Wang Q; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Leal-Cardoso JH; Laboratório de Eletrofisiologia, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
Rossoni LV; Laboratório de Fisiologia Vascular, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2015 Jul; Vol. 172 (14), pp. 3484-94. Date of Electronic Publication: 2015 May 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Blood Pressure/*drug effects
Endothelial Cells/*drug effects
Endothelial Cells/*metabolism
Eugenol/*pharmacology
Mesenteric Arteries/*drug effects
TRPV Cation Channels/*metabolism
Vasodilation/*drug effects
Animals ; Dose-Response Relationship, Drug ; Male ; Rats ; Rats, Wistar ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation.
Autorzy :
Sullivan MN; Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Gonzales AL; Department of Pharmacology, University of Vermont School of Medicine, Burlington, VT 05405, USA.
Pires PW; Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557-0318, USA.
Bruhl A; Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Leo MD; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Li W; Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Oulidi A; Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557-0318, USA.
Boop FA; Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Feng Y; Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Jaggar JH; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Welsh DG; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Earley S; Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557-0318, USA. .
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Źródło :
Science signaling [Sci Signal] 2015 Jan 06; Vol. 8 (358), pp. ra2. Date of Electronic Publication: 2015 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels/*metabolism
Calcium Signaling/*physiology
Cerebral Arteries/*physiology
Nerve Tissue Proteins/*metabolism
Reactive Oxygen Species/*pharmacology
Transient Receptor Potential Channels/*metabolism
Vasodilation/*drug effects
Aldehydes/metabolism ; Animals ; Blotting, Western ; Calcium Channels/genetics ; Calcium Signaling/drug effects ; Cerebral Arteries/drug effects ; HEK293 Cells ; Humans ; Immunohistochemistry ; Immunoprecipitation ; Lipid Peroxidation/physiology ; Membrane Glycoproteins/metabolism ; Membrane Potentials/physiology ; Mice ; Mice, Knockout ; NADPH Oxidase 2 ; NADPH Oxidases/metabolism ; Nerve Tissue Proteins/genetics ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; TRPA1 Cation Channel ; Transient Receptor Potential Channels/genetics ; Vasodilation/physiology
Czasopismo naukowe
Tytuł :
The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Centre, 894 Union Avenue, Suite 426, Memphis, TN 38163, USA.
Leo MD
Narayanan D
Jangsangthong W
Nair A
Evanson KW
Pachuau J
Gabrick KS
Boop FA
Jaggar JH
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Źródło :
The Journal of physiology [J Physiol] 2013 Jun 15; Vol. 591 (12), pp. 2987-98. Date of Electronic Publication: 2013 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Vasodilation*
Calcium Channels, L-Type/*metabolism
Muscle, Smooth, Vascular/*metabolism
Action Potentials ; Active Transport, Cell Nucleus ; Adolescent ; Animals ; Calcium Channels, L-Type/chemistry ; Calcium Channels, L-Type/genetics ; Cell Nucleus/metabolism ; Cerebral Arteries/cytology ; Cerebral Arteries/physiology ; Humans ; Male ; Muscle, Smooth, Vascular/physiology ; Mutation ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/physiology ; Nuclear Localization Signals ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Hydrogen sulfide activates Ca²⁺ sparks to induce cerebral arteriole dilatation.
Autorzy :
Liang GH; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Xi Q
Leffler CW
Jaggar JH
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Źródło :
The Journal of physiology [J Physiol] 2012 Jun 01; Vol. 590 (11), pp. 2709-20. Date of Electronic Publication: 2012 Apr 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*blood supply
Calcium/*physiology
Hydrogen Sulfide/*pharmacology
Myocytes, Smooth Muscle/*drug effects
Vasodilation/*drug effects
Animals ; Arterioles/drug effects ; Arterioles/physiology ; Brain/drug effects ; Brain/physiology ; In Vitro Techniques ; Membrane Potentials/drug effects ; Myocytes, Smooth Muscle/physiology ; Potassium Channels, Calcium-Activated/physiology ; Ryanodine Receptor Calcium Release Channel/physiology ; Sarcoplasmic Reticulum/physiology ; Swine
Czasopismo naukowe
Tytuł :
Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice.
Autorzy :
Adebiyi A; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
McNally EM
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2011 Oct; Vol. 301 (4), pp. H1360-8. Date of Electronic Publication: 2011 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
ATP-Binding Cassette Transporters/*physiology
Cerebral Arteries/*physiology
Glucose/*deficiency
Hypoxia/*physiopathology
Potassium Channels, Inwardly Rectifying/*physiology
Receptors, Drug/*physiology
Vasodilation/*physiology
ATP-Binding Cassette Transporters/genetics ; Adenosine Triphosphate/biosynthesis ; Animals ; Blotting, Western ; Cerebral Arteries/anatomy & histology ; Female ; Homeostasis ; Hypoxia/genetics ; KATP Channels/physiology ; Male ; Mice ; Mice, Knockout ; Mitochondria/metabolism ; Myocytes, Smooth Muscle/metabolism ; Pinacidil/pharmacology ; Potassium Channels, Inwardly Rectifying/genetics ; Receptors, Drug/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sulfonylurea Receptors ; Vasodilation/genetics ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.
Autorzy :
Liang GH; Dept. of Physiology, Univ. of Tennessee Health Science Ctr., Memphis, TN 38163, USA.
Adebiyi A
Leo MD
McNally EM
Leffler CW
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2011 Jun; Vol. 300 (6), pp. H2088-95. Date of Electronic Publication: 2011 Mar 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Membrane/*metabolism
Cerebral Arteries/*drug effects
Hydrogen Sulfide/*pharmacology
KATP Channels/*metabolism
Muscle, Smooth, Vascular/*metabolism
Vasodilation/*drug effects
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Arterioles/drug effects ; Arterioles/physiology ; Cerebral Arteries/physiology ; Female ; Glyburide/pharmacology ; KATP Channels/drug effects ; Male ; Mice ; Mice, Knockout ; Models, Animal ; Patch-Clamp Techniques ; Pinacidil/pharmacology ; Potassium Channels, Inwardly Rectifying/genetics ; Potassium Channels, Inwardly Rectifying/metabolism ; Receptors, Drug/genetics ; Receptors, Drug/metabolism ; Sulfonylurea Receptors ; Swine ; Vasodilation/physiology ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Smooth muscle cell alpha2delta-1 subunits are essential for vasoregulation by CaV1.2 channels.
Autorzy :
Bannister JP; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Adebiyi A
Zhao G
Narayanan D
Thomas CM
Feng JY
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2009 Nov 06; Vol. 105 (10), pp. 948-55. Date of Electronic Publication: 2009 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels, L-Type/*metabolism
Cerebral Arteries/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Vasoconstriction/*physiology
Vasodilation/*physiology
Animals ; Anticonvulsants/pharmacology ; Calcium/metabolism ; Cells, Cultured ; Cerebral Arteries/cytology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Gene Knockdown Techniques ; Male ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/cytology ; Pregabalin ; Protein Isoforms/metabolism ; Protein Subunits/metabolism ; Rats ; Rats, Sprague-Dawley ; Vasoconstriction/drug effects ; Vasodilation/drug effects ; gamma-Aminobutyric Acid/analogs & derivatives ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels.
Autorzy :
Li A; Department of Physiology, University of Tennessee Health Science Center, Memphis, USA.
Xi Q
Umstot ES
Bellner L
Schwartzman ML
Jaggar JH
Leffler CW
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Źródło :
Circulation research [Circ Res] 2008 Feb 01; Vol. 102 (2), pp. 234-41. Date of Electronic Publication: 2007 Nov 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cerebrovascular Circulation*
Second Messenger Systems*
Vasodilation*
Astrocytes/*metabolism
Carbon Monoxide/*physiology
Myocytes, Smooth Muscle/*metabolism
Potassium Channels, Calcium-Activated/*metabolism
Arterioles/physiology ; Astrocytes/physiology ; Carbon Monoxide/metabolism ; Glutamates/physiology ; Heme Oxygenase (Decyclizing)/metabolism ; Myocytes, Smooth Muscle/chemistry ; Paracrine Communication
Czasopismo naukowe
Tytuł :
TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation.
Autorzy :
Cheranov SY; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 426 Nash Research Bldg., Memphis, 38163, USA.
Jaggar JH
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2006 Apr; Vol. 290 (4), pp. C964-71. Date of Electronic Publication: 2005 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling/*physiology
Cerebral Arteries/*drug effects
Cerebral Arteries/*metabolism
NADPH Oxidases/*metabolism
Tumor Necrosis Factor-alpha/*pharmacology
Vasodilation/*physiology
Animals ; Calcium-Transporting ATPases/metabolism ; Cerebral Arteries/cytology ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Female ; Humans ; Male ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Patch-Clamp Techniques ; Potassium Channels, Calcium-Activated/metabolism ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Mitochondria-derived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks.
Autorzy :
Xi Q; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Cheranov SY
Jaggar JH
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Źródło :
Circulation research [Circ Res] 2005 Aug 19; Vol. 97 (4), pp. 354-62. Date of Electronic Publication: 2005 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Reactive Oxygen Species*
Vasodilation*/drug effects
Calcium/*metabolism
Cerebral Arteries/*physiology
Mitochondria/*physiology
Potassium Channels/*physiology
Adenosine Triphosphate/pharmacology ; Animals ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/analogs & derivatives ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Diazoxide/pharmacology ; Female ; Male ; Muscle, Smooth, Vascular/physiology ; Potassium Channels/drug effects ; Rats ; Rats, Sprague-Dawley ; Rotenone/pharmacology ; Ryanodine Receptor Calcium Release Channel/physiology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Permissive contributions of NO and prostacyclin in CO-induced cerebrovascular dilation in piglets.
Autorzy :
Leffler CW; Dept. of Physiology, 894 Union Ave., Memphis, TN 38163, USA. />Fedinec AL
Parfenova H
Jaggar JH
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2005 Jul; Vol. 289 (1), pp. H432-8. Date of Electronic Publication: 2005 Feb 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Carbon Monoxide/*physiology
Cerebrovascular Circulation/*physiology
Epoprostenol/*physiology
Nitric Oxide/*physiology
Vasodilation/*physiology
Animals ; Animals, Newborn ; Arterioles/physiology ; Carbon Monoxide/pharmacology ; Cerebrovascular Circulation/drug effects ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; Cyclic GMP-Dependent Protein Kinases/physiology ; Pia Mater/blood supply ; Swine
Czasopismo naukowe
Tytuł :
The permissive role of endothelial NO in CO-induced cerebrovascular dilation.
Autorzy :
Barkoudah E; Dept. of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA.
Jaggar JH
Leffler CW
Pokaż więcej
Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2004 Oct; Vol. 287 (4), pp. H1459-65. Date of Electronic Publication: 2004 Jun 10.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Carbon Monoxide/*metabolism
Nitric Oxide Synthase/*metabolism
Vasodilation/*physiology
Animals ; Arterioles/metabolism ; Cerebral Arteries/metabolism ; Cyclic GMP/analogs & derivatives ; Cyclic GMP/metabolism ; Cyclic GMP/pharmacology ; Endothelium, Vascular/metabolism ; Enzyme Inhibitors/pharmacology ; Female ; Male ; Muscle, Smooth, Vascular/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Donors/pharmacology ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase Type III ; Nitroarginine/pharmacology ; Nitroprusside/pharmacology ; Oxadiazoles/pharmacology ; Pia Mater/blood supply ; Potassium Channel Blockers/pharmacology ; Quinoxalines/pharmacology ; Swine ; Tetraethylammonium/pharmacology ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs.
Autorzy :
Fiumana E; Department of Physiology, Vascular Biology Center, University of Tennessee Health Sciences Center, Memphis, 38163, USA.
Parfenova H
Jaggar JH
Leffler CW
Pokaż więcej
Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2003 Apr; Vol. 284 (4), pp. H1073-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Animals, Newborn/*physiology
Arterioles/*physiology
Brain/*blood supply
Carbon Monoxide/*physiology
Cycloleucine/*analogs & derivatives
Glutamic Acid/*pharmacology
Vasodilation/*drug effects
Animals ; Arterioles/drug effects ; Cycloleucine/pharmacology ; Endothelium, Vascular/enzymology ; Endothelium, Vascular/physiology ; Enzyme Inhibitors/pharmacology ; Fluorescent Antibody Technique ; Heme Oxygenase (Decyclizing)/analysis ; Heme Oxygenase (Decyclizing)/antagonists & inhibitors ; In Vitro Techniques ; Isoenzymes/analysis ; Mesoporphyrins/pharmacology ; Pressure ; Receptors, N-Methyl-D-Aspartate/agonists ; Swine ; Vasodilation/physiology
Czasopismo naukowe
    Wyświetlanie 1-16 z 16

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