Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use.
Autorzy:
Tu IF; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Lin TL; Department of Microbiology, National Taiwan University Hospital, Taipei, 100, Taiwan. Yang FL; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Lee IM; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Tu WL; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Liao JH; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Ko TP; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Wu WJ; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. JanJT; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan. Ho MR; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Chou CY; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Wang AH; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. Wu CY; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan. Wang JT; Department of Microbiology, National Taiwan University Hospital, Taipei, 100, Taiwan. Huang KF; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. . Wu SH; Institute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan‑Kang, Taipei, 115, Taiwan. .; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan. .
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Journal of biomedical science [J Biomed Sci] 2022 Feb 07; Vol. 29 (1), pp. 9. Date of Electronic Publication: 2022 Feb 07.
Antibody cocktail effective against variants of SARS-CoV-2.
Autorzy:
Liang KH; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan.; Institute of Cellular and Organismic Biology, Academia Sinica, No. 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan. Chiang PY; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan. Ko SH; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan. Chou YC; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan. Lu RM; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan. Lin HT; Institute of Cellular and Organismic Biology, Academia Sinica, No. 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan. Chen WY; Institute of Cellular and Organismic Biology, Academia Sinica, No. 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan. Lin YL; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan. Tao MH; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan. JanJT; Genomics Research Center, Academia Sinica, Taipei, 11529, Taiwan. Wu HC; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, 11529, Taiwan. .; Institute of Cellular and Organismic Biology, Academia Sinica, No. 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan. .
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Journal of biomedical science [J Biomed Sci] 2021 Nov 23; Vol. 28 (1), pp. 80. Date of Electronic Publication: 2021 Nov 23.
Structure-guided antibody cocktail for prevention and treatment of COVID-19.
Autorzy:
Su SC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Yang TJ; Institute of Biologic Chemistry, Academia Sinica, Taipei, Taiwan.; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan. Yu PY; Institute of Biologic Chemistry, Academia Sinica, Taipei, Taiwan. Liang KH; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Chen WY; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Yang CW; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Lin HT; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Wang MJ; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Lu RM; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Tso HC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Chung MJ; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Hsieh TY; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Chang YL; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Lin SC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Hsu FY; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Ke FY; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Wu YH; Institute of Biologic Chemistry, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Hwang YC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Liu IJ; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Liang JJ; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Liao CC; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Ko HY; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Sun CP; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Wu PY; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. JanJT; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Chang YC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Institute of Biologic Chemistry, Academia Sinica, Taipei, Taiwan. Lin YL; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Tao MH; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Hsu SD; Institute of Biologic Chemistry, Academia Sinica, Taipei, Taiwan.; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan. Wu HC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan.
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PLoS pathogens [PLoS Pathog] 2021 Oct 21; Vol. 17 (10), pp. e1009704. Date of Electronic Publication: 2021 Oct 21 (Print Publication: 2021).
Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters.
Autorzy:
Kulkarni R; Molecular and Cell Biology, Taiwan International Graduate Program, National Defense Medical Center, Academia Sinica and Graduate Institute of Life Science, Taipei, Taiwan.; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Chen WC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Lee Y; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Kao CF; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Hu SL; Department of Pharmaceutics, University of Washington, Seattle, Washington, United States of America. Ma HH; Genomics Research Center, Academia Sinica, Taipei, Taiwan. JanJT; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Liao CC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Liang JJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Ko HY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Sun CP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Lin YS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Wang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Academi Sinica SPF Animal Facility, Academia Sinica, Taipei, Taiwan. Wei SC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Ma C; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Chao YC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Chou YC; Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei, Taiwan. Chang W; Molecular and Cell Biology, Taiwan International Graduate Program, National Defense Medical Center, Academia Sinica and Graduate Institute of Life Science, Taipei, Taiwan.; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
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Źródło:
PloS one [PLoS One] 2021 Sep 09; Vol. 16 (9), pp. e0257191. Date of Electronic Publication: 2021 Sep 09 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19.
Autorzy:
Sun CP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. JanJT; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Wang IH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Ma HH; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Ko HY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Wu PY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Kuo TJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Liao HN; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Lan YH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Sie ZL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Chen YH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Ko YA; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan. Liao CC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Chen LY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Lee IJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Microbiology, National Taiwan University, Taipei, Taiwan. Tsung SI; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Lai YJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Solomont School of Nursing, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Massachusetts, United States of America. Chiang MT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Liang JJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Liu WC; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan. Wang JR; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan. Yuan JP; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan. Lin YS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Tsai YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Hsieh SL; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Li CW; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Wu HC; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. Ko TM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan.; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan. Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan. Tao MH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.
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PLoS pathogens [PLoS Pathog] 2021 Aug 11; Vol. 17 (8), pp. e1009758. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021).
CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge.
Autorzy:
Lien CE; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan. Lin YJ; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan. Chen C; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.; Temple University, Philadelphia, PA, 19122, USA. Lian WC; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan. Kuo TY; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.; Department of Biotechnology and Animal Science, National Ilan University, Yilan County, Taiwan. Campbell JD; Dynavax Technologies, Emeryville, CA, 94608, USA. Traquina P; Dynavax Technologies, Emeryville, CA, 94608, USA. Lin MY; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan. Liu LT; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan. Chuang YS; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan. Ko HY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Liao CC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Chen YH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. JanJT; Genomic Research Center, Academia Sinica, Taipei, Taiwan. Ma HH; Genomic Research Center, Academia Sinica, Taipei, Taiwan. Sun CP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Lin YS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Wu PY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Wang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Tao MH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. .; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan. . Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. .; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan. .
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Scientific reports [Sci Rep] 2021 Apr 22; Vol. 11 (1), pp. 8761. Date of Electronic Publication: 2021 Apr 22.
Breadth and function of antibody response to acute SARS-CoV-2 infection in humans.
Autorzy:
Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. Chen TH; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Huang CG; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Harvey R; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, United Kingdom. Hussain S; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, United Kingdom. Chen CP; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and National Yang-Ming University, Taipei, Taiwan. Harding A; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. Gilbert-Jaramillo J; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. Liu X; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. Knight M; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. Schimanski L; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom. Shih SR; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Lin YC; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and Taipei Medical University, Taipei, Taiwan. Cheng CY; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and National Yang-Ming University, Taipei, Taiwan. Cheng SH; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and Taipei Medical University, Taipei, Taiwan. Huang YC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Lin TY; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. JanJT; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Ma C; Genomics Research Center, Academia Sinica, Taipei, Taiwan. James W; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. Daniels RS; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, United Kingdom. McCauley JW; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, United Kingdom. Rijal P; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom. Townsend AR; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom.
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PLoS pathogens [PLoS Pathog] 2021 Feb 26; Vol. 17 (2), pp. e1009352. Date of Electronic Publication: 2021 Feb 26 (Print Publication: 2021).
Glycan masking of hemagglutinin for adenovirus vector and recombinant protein immunizations elicits broadly neutralizing antibodies against H5N1 avian influenza viruses.
Autorzy:
Lin SC; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. Liu WC; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. JanJT; Genomics Research Center, Academia Sinica, Taipei, Taiwan. Wu SC; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan; Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
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Źródło:
PloS one [PLoS One] 2014 Mar 26; Vol. 9 (3), pp. e92822. Date of Electronic Publication: 2014 Mar 26 (Print Publication: 2014).
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